Updated on 2025/12/06

写真a

 
ODAGI, Minami
 
Affiliation
Faculty of Science and Engineering, Graduate School of Advanced Science and Engineering
Job title
Assistant Professor(non-tenure-track)

Research Experience

  • 2025.03
    -
    Now

    Waseda University   Graduate School of Advanced Science and Engineering

  • 2024.04
    -
    2025.03

    Tokyo University of Agriculture

  • 2015.10
    -
    2024.03

    Tokyo University of Agriculture and Technology

  • 2017.10
    -
    2018.09

    フロリダ大学   化学科   訪問研究員

  • 2015.04
    -
    2015.09

    日本学術振興会   特別研究員(DC2)

Education Background

  •  
    -
    2015.09

    Tokyo University of Agriculture and Technology   Graduate School of Engineering   Department of Biotechnology and Life Science  

  •  
    -
    2013.03

    Tokyo University of Agriculture and Technology   Graduate School of Engineering   Department of Biotechnology and Life Science  

  •  
    -
    2011.03

    Tamagawa University   College of Agriculture   Department of Life Science  

Research Areas

  • Bioorganic chemistry

Research Interests

  • 天然物合成

  • 不斉触媒

  • 有機合成化学

Awards

  • Thieme Chemistry Journals Award

    2024.01   Thieme Chemistry  

  • 天然物化学談話会奨励賞

    2023.07  

  • 若い世代の特別講演会 講演証

    2023.03   日本化学会  

  • 有機合成化学奨励賞

    2023.02   有機合成化学協会  

  • 第一三共 研究企画賞

    2023.02   有機合成化学協会  

 

Papers

  • Enantioselective Gram-Scale Synthesis of Rasagiline via Chiral Phosphoric Acid-Catalyzed Reduction of Cyclic Imine

    Hayate Ishizuka, Toma Osawa, Yuta Shimizu, Hideyuki Sogo, Ryoya Imaizumi, Naohisa Shiba, Ayato Nureki, Taisei Matoba, Minami Odagi, Kazuo Nagasawa

    CHEMISTRY-AN ASIAN JOURNAL    2025.08

    DOI

    Scopus

  • Catalytic Enantioselective Oxidative Dearomatization of 1-Naphthols Using Chiral Iminium Salts

    Takuma Inayama, Kouki Orimo, Minami Odagi, Arata Yajima, Tatsuo Saito

    ACS CATALYSIS   15 ( 16 ) 13910 - 13915  2025.08

    DOI

    Scopus

    1
    Citation
    (Scopus)
  • Enantioselective Oxidative Homocoupling of 2-Oxindoles with a Chiral Bisguanidinium Hypoiodite Catalyst

    Minami Odagi, Yuta Shimizu, Kota Sugimoto, Io Mori, Ban Xu, Choon Hong Tan, Kazuo Nagasawa

    SYNLETT   36 ( 05 ) 468 - 473  2025.03

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    1
    Citation
    (Scopus)
  • Covalent Plant Natural Product that Potentiates Antitumor Immunity

    Misao Takemoto, Sara Delghandi, Masahiro Abo, Keiko Yurimoto, Minami Odagi, Vaibhav Pal Singh, Jun Wang, Reiko Nakagawa, Shin-ichi Sato, Yasushi Takemoto, Asmaa M. A. S. Farrag, Yoshimasa Kawaguchi, Kazuo Nagasawa, Tasuku Honjo, Kenji Chamoto, Motonari Uesugi

    Journal of the American Chemical Society    2025.01

    DOI

    Scopus

    4
    Citation
    (Scopus)
  • Catalytic enantioselective synthesis of 2-pyrazolines via one-pot condensation/6π-electrocyclization: 3,5-bis(pentafluorosulfanyl)-phenylthioureas as powerful hydrogen bond donors

    Moises A. Romero Reyes, Subhradeep Dutta, Minami Odagi, Chang Min, Daniel Seidel

    CHEMICAL SCIENCE   15 ( 37 ) 15456 - 15462  2024.09

    DOI

    Scopus

    1
    Citation
    (Scopus)
  • Catalytic Enantioselective [4+2] Cycloadditions of Salicylaldehyde Acetals with Enol Ethers.

    Xiaojun Hu, Zhengbo Zhu, Zhongzheng Li, Alafate Adili, Minami Odagi, Khalil A Abboud, Daniel Seidel

    Angewandte Chemie (International ed. in English)   63 ( 4 ) e202315759  2024.01  [International journal]

     View Summary

    A readily accessible conjugate-base-stabilized carboxylic acid (CBSCA) catalyst facilitates highly enantioselective [4+2] cycloaddition reactions of salicylaldehyde-derived acetals and cyclic enol ethers, resulting in the formation of polycyclic chromanes with oxygenation in the 2- and 4-positions. Stereochemically more complex products can be obtained from racemic enol ethers. Spirocyclic products are also accessible.

    DOI PubMed

    Scopus

    8
    Citation
    (Scopus)
  • Discovery and Structural Analysis of Metabolites of Vitamin D3 Lactones.

    Kazuto Iijima, Ryota Sakamoto, Rino Tsutsumi, Naoto Nakaya, Takatsugu Hirokawa, Minami Odagi, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa

    Chemical & pharmaceutical bulletin   72 ( 10 ) 899 - 908  2024  [Domestic journal]

     View Summary

    25-Hydroxyvitamin D3-23,26-lactone (1) and 1α,25-dihydroxyvitamin D3-23,26-lactone (2) have long been considered as among the end metabolites of vitamin D3. Recently, however, we found that these lactones exhibit biological activity related to the β-oxidation of fatty acids. We hypothesized that a metabolic pathway might exist to inactivate their physiological activity. Here, by means of metabolic experiments with a variety of cytochrome P450 (CYP) enzymes, we show that CYP3A4 metabolizes the lactones. The metabolites were presumed to be hydroxylated at C4 based on the previous reports showing that metabolism of 25-hydroxyvitamin D3 by CYP3A4 along with the current LC-MS analysis. To confirm this, we chemically synthesized 4α,25(OH)2D3-23,26-lactone (3), 4β,25(OH)2D3-23,26-lactone (4), 1α,4α,25(OH)3D3-23,26-lactone (5), and 1α,4β,25(OH)3D3-23,26-lactone (6). HPLC analysis using these authentic compounds as standards revealed that 1 was metabolized to 3 and 4, while 2 was metabolized exclusively to 6 by CYP3A4. Docking studies suggest that the hydroxyl group at C1 in 2 forms hydrogen bonds with Ser119 and Arg212 of CYP3A4, contributing to the fixation of C4β on heme iron in the CYP, thereby resulting in stereoselective hydroxylation at C4.

    DOI PubMed

    Scopus

  • Approaches to Construction of the Medium-Sized Ring Structure in Zetekitoxin AB by Ring-Closing Metathesis

    Hayate Ishizuka, Ayato Nureki, Kanna Adachi, Yuka Takayanagi, Minami Odagi, Mari Yotsu-Yamashita, Kazuo Nagasawa

    The Journal of Organic Chemistry   88 ( 14 ) 10223 - 10231  2023.06

    DOI

    Scopus

    3
    Citation
    (Scopus)
  • Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D3 and Identification of Their Metabolites

    Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa

    Biomolecules   13 ( 7 ) 1036 - 1036  2023.06

     View Summary

    Vitamin D3 (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D3 (6a) and 4β,25-dihydroxyvitamin D3 (6b) are both produced from 25-hydroxyvitamin D3 (2) by CYP3A4. However, 6b is detectable in serum, whereas 6a is not. We hypothesized that the reason for this is a difference in the susceptibility of 6a and 6b to CYP24A1-mediated metabolism. Here, we synthesized 6a and 6b, and confirmed that 6b has greater metabolic stability than 6a. We also identified 4α,24R,25- and 4β,24R,25-trihydroxyvitamin D3 (16a and 16b) as metabolites of 6a and 6b, respectively, by HPLC comparison with synthesized authentic samples. Docking studies suggest that the β-hydroxy group at C4 contributes to the greater metabolic stability of 6b by blocking a crucial hydrogen-bonding interaction between the C25 hydroxy group and Leu325 of CYP24A1.

    DOI

    Scopus

    4
    Citation
    (Scopus)
  • Stereoselective Construction of Tertiary Alcohol at C11 of Zetekitoxin AB

    Ayato Nureki, Kanna Adachi, Hayate Ishizuka, Kako Maeno, Yayoi Orihara, Minami Odagi, Mari Yotsu-Yamashita, Kazuo Nagasawa

    Asian Journal of Organic Chemistry    2023.05

    DOI

    Scopus

    2
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    (Scopus)
  • Enantioselective Oxidative Enolate Coupling of Oxindoles Catalyzed by Chiral Guanidinium Hypoiodite

    Minami Odagi, Io Mori, Kota Sugimoto, Kazuo Nagasawa

    ACS Catalysis   13 ( 4 ) 2295 - 2301  2023.02

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    7
    Citation
    (Scopus)
  • Synthetic Studies of Hasubanan Alkaloids Based on Oxidative Phenolic Coupling and Intramolecular Aza -Michael Reaction

    Minami Odagi

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN    2023

    DOI

    Scopus

  • Synthesis of Pentacyclic Core Structure of Aspidosperma Alkaloids by Sequential Ring Construction via Oxidative Phenolic Coupling

    Minami Odagi

    CHEMISTRY LETTERS    2023

    DOI

  • Development of Asymmetric Oxidation Reactions Catalyzed by Guanidinium-bisurea Bifunctional Organocatalysts Utilizing Computational Methods

    Minami Odagi

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN    2023

    DOI

  • Chiral Hypoiodite Salt Catalysts for Enantioselective Oxidative Transformations

    Minami Odagi

    CHEMCATCHEM    2023

    DOI

  • Guanidinium Hypoiodite-Catalyzed Intramolecular Oxidative Coupling Reaction of Oxindoles with β-Dicarbonyls

    Minami Odagi

    JOURNAL OF ORGANIC CHEMISTRY    2023.01

    Authorship:Corresponding author

    DOI PubMed

  • Nontoxic Enantiomeric Reference Materials for Saxitoxins

    Ryuichi Watanabe, Yuka Takayanagi, Osamu Chiba, Shota Itoda, Hayate Ishizuka, Minami Odagi, Mayu Ozawa, Hajime Uchida, Ryoji Matsushima, Keiichi Konoki, Mari Yotsu-Yamashita, Kazuo Nagasawa, Toshiyuki Suzuki

    Analytical Chemistry    2022.08

    DOI

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    7
    Citation
    (Scopus)
  • Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D3 Derivatives: Stereoselectivity and Biological Activity

    Yuka Mizumoto, Ryota Sakamoto, Akiko Nagata, Suzuka Sakane, Atsushi Kittaka, Minami Odagi, Masayuki Tera, Kazuo Nagasawa

    Biomolecules   12 ( 1 ) 69 - 69  2022.01

     View Summary

    The active form of vitamin D3 (D3), 1a,25-dihydroxyvitamn D3 (1,25D3), plays a central role in calcium and bone metabolism. Many structure–activity relationship (SAR) studies of D3 have been conducted, with the aim of separating the biological activities of 1,25D3 or reducing its side effects, such as hypercalcemia, and SAR studies have shown that the hypercalcemic activity of C2-substituted derivatives and 19-nor type derivatives is significantly suppressed. In the present paper, we describe the synthesis of 19-nor type 1,25D3 derivatives with alkoxy groups at C2, by means of the Julia–Kocienski type coupling reaction between a C2 symmetrical A ring ketone and a CD ring synthon. The effect of C2 substituents on the stereoselectivity of the coupling reaction was evaluated. The biological activities of the synthesized derivatives were evaluated in an HL-60 cell-based assay. The a-methoxy-substituted C2α-7a was found to show potent cell-differentiating activity, with an ED50 value of 0.38 nM, being 26-fold more potent than 1,25D3.

    DOI

    Scopus

    3
    Citation
    (Scopus)
  • Enantioselective Total Synthesis of Cepharatines via Bioinspired Ring Reconstruction

    Minami Odagi, Taisei Matoba, Kazuo Nagasawa

    The Journal of Organic Chemistry    2021.11

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    11
    Citation
    (Scopus)
  • Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite.

    Mendoza A, Takemoto Y, Cruzado KT, Masoud SS, Nagata A, Tantipanjaporn A, Okuda S, Kawagoe F, Sakamoto R, Odagi M, Mototani S, Togashi M, Kawatani M, Uesugi M

    Cell chemical biology    2021.09  [International journal]

     View Summary

    Lactone-vitamin D3 is a major metabolite of vitamin D3, a lipophilic vitamin biosynthesized in numerous life forms by sunlight exposure. Although lactone-vitamin D3 was discovered 40 years ago, its biological role remains largely unknown. Chemical biological analysis of its photoaffinity probe identified the hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha (HADHA), a mitochondrial enzyme that catalyzes β-oxidation of long-chain fatty acids, as its selective binding protein. Intriguingly, the interaction of lactone-vitamin D3 with HADHA does not affect the HADHA enzymatic activity but instead limits biosynthesis of carnitine, an endogenous metabolite required for the transport of fatty acids into the mitochondria for β-oxidation. Lactone-vitamin D3 dissociates the protein-protein interaction of HADHA with trimethyllysine dioxygenase (TMLD), thereby impairing the TMLD enzyme activity essential in carnitine biosynthesis. These findings suggest a heretofore undescribed role of lactone-vitamin D3 in lipid β-oxidation and carnitine biosynthesis, and possibly in sunlight-dependent shifts of lipid metabolism in animals.

    DOI PubMed

    Scopus

    19
    Citation
    (Scopus)
  • Mechanistic insights into entropy-driven 1,2-type Friedel-Crafts reaction with conformationally flexible guanidine-bisthiourea bifunctional organocatalysts

    Katsuhiro Nakano, Tatsuya Orihara, Masaki Kawaguchi, Keisuke Hosoya, Shogo Hirao, Ryosuke Tsutsumi, Masahiro Yamanaka, Minami Odagi, Kazuo Nagasawa

    Tetrahedron   92   132281 - 132281  2021.07

    Authorship:Corresponding author

    DOI

    Scopus

    9
    Citation
    (Scopus)
  • Enantioselective Total Synthesis of (+)-Stephadiamine through Bioinspired Aza-Benzilic Acid Type Rearrangement

    Minami Odagi

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY    2021.02

    Authorship:Lead author, Corresponding author

    DOI PubMed

  • Enantioselective Epoxidation of 2,3-Disubstituted Naphthoquinones by a Side Chain Truncated Guanidine–Urea Bifunctional Organocatalyst

    Tatsuya Orihara, Masaki Kawaguchi, Keisuke Hosoya, Ryosuke Tsutsumi, Masahiro Yamanaka, Minami Odagi, Kazuo Nagasawa

    The Journal of Organic Chemistry   85 ( 23 ) 15232 - 15240  2020.12

    Authorship:Corresponding author

    DOI

    Scopus

    6
    Citation
    (Scopus)
  • Synthesis of C12-Keto Saxitoxin Derivatives with Unusual Inhibitory Activity Against Voltage-Gated Sodium Channels.

    Kanna Adachi, Tomoshi Yamada, Hayate Ishizuka, Mana Oki, Shunsuke Tsunogae, Noriko Shimada, Osamu Chiba, Tatsuya Orihara, Masafumi Hidaka, Takatsugu Hirokawa, Minami Odagi, Keiichi Konoki, Mari Yotsu-Yamashita, Kazuo Nagasawa

    Chemistry (Weinheim an der Bergstrasse, Germany)   26 ( 9 ) 2025 - 2033  2020.02  [Refereed]  [International journal]

     View Summary

    A novel series of C12-keto-type saxitoxin (STX) derivatives bearing an unusual nonhydrated form of the ketone at C12 has been synthesized, and their NaV -inhibitory activity has been evaluated in a cell-based assay as well as whole-cell patch-clamp recording. Among these compounds, 11-benzylidene STX (3 a) showed potent inhibitory activity against neuroblastoma Neuro 2A in both cell-based and electrophysiological analyses, with EC50 and IC50 values of 8.5 and 30.7 nm, respectively. Interestingly, the compound showed potent inhibitory activity against tetrodotoxin-resistant subtype of NaV 1.5, with an IC50 value of 94.1 nm. Derivatives 3 a-d and 3 f showed low recovery rates from NaV 1.2 subtype (ca 45-79 %) compared to natural dcSTX (2), strongly suggesting an irreversible mode of interaction. We propose an interaction model for the C12-keto derivatives with NaV in which the enone moiety in the STX derivatives 3 works as Michael acceptor for the carboxylate of Asp1717 .

    DOI PubMed

    Scopus

    13
    Citation
    (Scopus)
  • Synthesis of Spiroguanidine Derivatives by Dearomative Oxidative Cyclization using Hypervalent Iodine Reagent

    Minami Odagi

    Asian Journal of Organic Chemistry   9 ( 2 )  2020.02

    Authorship:Lead author, Corresponding author

    DOI

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    14
    Citation
    (Scopus)
  • Highly Acidic Conjugate-Base-Stabilized Carboxylic Acids Catalyze Enantioselective oxa-Pictet–Spengler Reactions with Ketals

    Zhu, Z., Odagi, M., Zhao, C., Abboud, K.A., Kirm, H.U., Saame, J., L{\~o}kov, M., Leito, I., Seidel, D.

    Angewandte Chemie - International Edition   59 ( 5 )  2020  [Refereed]

    Authorship:Lead author

    DOI

    Scopus

    38
    Citation
    (Scopus)
  • Synthesis of Hydrocarbazole Derivatives by Oxidative Dearomative Cyclization of Diarylamines Using a Hypervalent Iodine Reagent

    Minami Odagi

    JOURNAL OF ORGANIC CHEMISTRY   85 ( 18 )  2020

    Authorship:Corresponding author

    DOI

  • Synthesis of isoxazolidines by intramolecular hydroamination of N-alkoxyamides in the presence of a visible-light photoredox catalyst

    Ishizuka, H., Adachi, K., Odagi, M., Nagasawa, K.

    Bulletin of the Chemical Society of Japan   92 ( 9 ) 1447 - 1449  2019.09  [Refereed]

    DOI

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    6
    Citation
    (Scopus)
  • Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25

    Nagata, A., Akagi, Y., Masoud, S.S., Yamanaka, M., Kittaka, A., Uesugi, M., Odagi, M., Nagasawa, K.

    Journal of Organic Chemistry   84 ( 12 ) 7630 - 7641  2019.06  [Refereed]

    DOI

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    15
    Citation
    (Scopus)
  • Insights into the Structure and Function of a Chiral Conjugate-Base-Stabilized BrOnsted Acid Catalyst

    Minami Odagi

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   2019 ( 2 ) 486 - 492  2019.01  [Refereed]

    Authorship:Lead author

    DOI

  • Synthesis of 2,6,7-Trisubstituted Prenylated indole

    Shiozawa Motoki, Iida Keisuke, Odagi Minami, Yamanaka Masahiro, Nagasawa Kazuo

    JOURNAL OF ORGANIC CHEMISTRY   83 ( 13 ) 7276 - 7280  2018.07  [Refereed]

    DOI

    Scopus

    9
    Citation
    (Scopus)
  • Asymmetric Epoxidation of 1,4-Naphthoquinones Catalyzed by Guanidine-Urea Bifunctional Organocatalyst

    Masaki Kawaguchi, Katsuhiro Nakano, Keisuke Hosoya, Tatsuya Orihara, Masahiro Yamanaka, Minami Odagi, Kazuo Nagasawa

    Organic Letters   20 ( 10 ) 2811 - 2815  2018.05  [Refereed]

    Authorship:Corresponding author

    DOI

    Scopus

    11
    Citation
    (Scopus)
  • Total Synthesis of (+)-Gracilamine Based on an Oxidative Phenolic Coupling Reaction and Determination of Its Absolute Configuration

    Minami Odagi, Yoshiharu Yamamoto, Kazuo Nagasawa

    Angewandte Chemie - International Edition   57 ( 8 ) 2229 - 2232  2018.02  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    36
    Citation
    (Scopus)
  • Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk

    Moshe Shashar, Mostafa E. Belghasem, Shinobu Matsuura, Joshua Walker, Sean Richards, Faisal Alousi, Keshab Rijal, Vijaya B. Kolachalama, Mercedes Balcells, Minami Odagi, Kazuo Nagasawa, Joel M. Henderson, Amitabh Gautam, Richard Rushmore, Jean Francis, Daniel Kirchhofer, Kumaran Kolandaivelu, David H. Sherr, Elazer R. Edelman, Katya Ravid, Vipul C. Chitalia

    SCIENCE TRANSLATIONAL MEDICINE   9 ( 417 )  2017.11  [Refereed]

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    44
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  • Guanidinium Hydroiodide/Cumene Hydroperoxide-Mediated Intermolecular Oxidative Coupling Reaction of beta-Ketoamides with Oxindoles

    Takanari Kato, Koji Yasui, Minami Odagi, Kazuo Nagasawa

    ADVANCED SYNTHESIS & CATALYSIS   359 ( 16 ) 2881 - 2889  2017.08  [Refereed]

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    8
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  • Oxidative Kinetic Resolution of cis-Fused Tricyclic 1-Tetralone Derivatives by Guanidine-Bisurea Bifunctional Organocatalyst

    Minami Odagi, Keisuke Hosoya, Yoshiharu Yamamoto, Kazuo Nagasawa

    SYNLETT   28 ( 11 ) 1305 - 1309  2017.07  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

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    5
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    (Scopus)
  • Total Synthesis of Rishirilide B by Organocatalytic Oxidative Kinetic Resolution: Revision of Absolute Configuration of (+)‐Rishirilide B

    Minami Odagi, Kota Furukori, Kan Takayama, Keiichi Noguchi, Kazuo Nagasawa

    Angewandte Chemie   129 ( 23 ) 6709 - 6712  2017.06

    DOI

  • Total Synthesis of Rishirilide B by Organocatalytic Oxidative Kinetic Resolution: Revision of Absolute Configuration of (+)-Rishirilide B

    Minami Odagi, Kota Furukori, Kan Takayama, Keiichi Noguchi, Kazuo Nagasawa

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   56 ( 23 ) 6609 - 6612  2017.06  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

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    20
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  • Guanidinium iodide/urea hydrogen peroxide-catalyzed azidation of beta-dicarbonyl compounds with trimethylsilyl azide

    Koji Yasui, Kohei Kojima, Takanari Kato, Minami Odagi, Masaru Kato, Kazuo Nagasawa

    TETRAHEDRON   72 ( 35 ) 5350 - 5354  2016.09  [Refereed]

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    13
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  • Asymmetric alpha-amination of beta-keto esters using a guanidine-bisurea bifunctional organocatalyst

    Minami Odagi, Yoshiharu Yamamoto, Kazuo Nagasawa

    BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY   12   198 - 203  2016.02  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

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    15
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    (Scopus)
  • Development of Guanidine-Bisurea Bifunctional Organocatalysts with a Chiral Pyrrolidine Moiety and Application to alpha-Hydroxylation of Tetralone-Derived beta-Keto Esters

    Minami Odagi, Kan Takayama, Makoto Sato, Masahiro Yamanaka, Kazuo Nagasawa

    MOLECULES   20 ( 7 ) 12590 - 12598  2015.07  [Refereed]

    DOI

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    5
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  • Development of Guanidine-Bisurea Bifunctional Organocatalyst Bearing Chirality at the Inner and Outer Sides of the Urea Groups, and Application to Enantioselective alpha-Hydroxylation of Pyranoindolizine Intermediate for Camptothecin Synthesis

    Minami Odagi, Tatsuya Watanabe, Kazuo Nagasawa

    SYMMETRY-BASEL   7 ( 1 ) 43 - 52  2015.03  [Refereed]

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    4
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  • Origin of Stereocontrol in Guanidine-Bisurea Bifunctional Organocatalyst That Promotes alpha-Hydroxylation of Tetralone-Derived beta-Ketoesters: Asymmetric Synthesis of beta- and gamma-Substituted Tetralone Derivatives via Organocatalytic Oxidative Kinetic Resolution

    Minami Odagi, Kota Furukori, Yoshiharu Yamamoto, Makoto Sato, Keisuke Iida, Masahiro Yamanaka, Kazuo Nagasawa

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   137 ( 5 ) 1909 - 1915  2015.02  [Refereed]

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    73
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  • Asymmetric alpha-Hydroxylation of a Lactone with Vinylogous Pyridone by Using a Guanidine-Urea Bifunctional Organocatalyst: Catalytic Enantioselective Synthesis of a Key Intermediate for (20S)-Camptothecin Analogues

    Tatsuya Watanabe, Minami Odagi, Kota Furukori, Kazuo Nagasawa

    CHEMISTRY-A EUROPEAN JOURNAL   20 ( 2 ) 591 - 597  2014.01  [Refereed]

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    18
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  • Development of Novel Guanidine-Bisurea Bifunctional Organocatalysts and their Application to Asymmetric alpha-Hydroxylation of Tetralone-derived beta-Keto Esters

    Minami Odagi, Kan Takayama, Kota Furukori, Tatsuya Watanabe, Kazuo Nagasawa

    AUSTRALIAN JOURNAL OF CHEMISTRY   67 ( 7 ) 1017 - 1020  2014  [Refereed]

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    10
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  • Asymmetric alpha-Hydroxylation of Tetralone-Derived beta-Ketoesters by Using a Guanidine-Urea Bifunctional Organocatalyst in the Presence of Cumene Hydroperoxide

    Minami Odagi, Kota Furukori, Tatsuya Watanabe, Kazuo Nagasawa

    CHEMISTRY-A EUROPEAN JOURNAL   19 ( 49 ) 16740 - 16745  2013.12  [Refereed]

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    49
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  • Asymmetric α–Hydroxylation of Tetralone Derived β–Ketoesters using Guanidine–Urea Bifunctional Organocatalyst in the Presence of Cumene Hydroperoxide

    T. Watanabe, M. Odagi, K. Furukori, K. Nagasawa

    Chem. Eur. J.   20   591 - 597  2013.11  [Refereed]

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Books and Other Publications

  • Modern Natural Product Synthesis

    Minami Odagi, Kazuo Nagasawa( Part: Contributor, Oxidative Phenolic Coupling Reaction/Aza-Michael Reaction Strategy for the Synthesis of Complex Polycyclic Alkaloids)

    Springer  2024.03 ISBN: 9789819716180

  • Guanidines as Reagents and Catalyst I

    ( Part: Contributor, Conformationally Flexible Guanidine-(Thio)Urea Bifunctional Organocatalysts)

    Springer  2017.07 ISBN: 9783319527239

  • 有機分子触媒の化学 : モノづくりのパラダイムシフト

    小田木陽, 長澤和夫( Part: Contributor, 官能基複合型不斉グアニジン触媒と生理活性物質合成への応用)

    化学同人  2016.11 ISBN: 9784759813821

Presentations

  • 脱芳香族化で拓く多環縮環型天然物の合成研究

    小田木陽  [Invited]

    第12回 慶應有機化学若手シンポジウム(KOシンポ) 

    Presentation date: 2025.05

  • 交差共役ジエノンの位置選択的官能基化を基盤とした天然物の合成研究

    小田木陽  [Invited]

    日本化学会第103春季年会 アジア国際シンポジウム 

    Presentation date: 2025.03

    Event date:
    2025.03
     
     
  • 官能基複合型鎖状グアニジン触媒による環境調和型物質変換反応の開発

    小田木陽  [Invited]

    先端化学・材料技術部会 高選択性反応分科会 講演会 

    Presentation date: 2024.08

  • 脱芳香族化反応を活用した高度官能基化天然物の合成研究

    小田木陽  [Invited]

    第107回触媒化学融合研究センター講演会 

    Presentation date: 2024.02

  • 脱芳香族化が拓く高度官能基化天然物の合成研究

    小田木陽  [Invited]

    第7回天然物化学研究会, 

    Presentation date: 2023.11

  • 脱芳香族化反応を活用した多環性縮環型アルカロイド類の合成研究

    小田木陽  [Invited]

    第39回有機合成セミナー 

    Presentation date: 2023.09

    Event date:
    2023.09
     
     
  • 脱芳香族化反応を基盤とした多環縮環型アルカロイド類の合成研究

    小田木陽  [Invited]

    日本化学会第103春季年会 若い世代の講演会 

    Presentation date: 2023.03

    Event date:
    2023.03
     
     
  • Total Synthesis of Hasubanan Alkaloids Based on Oxidative Phenolic Coupling Reaction and Aza-Michael Reaction

    Minami Odagi  [Invited]

    11th Singapore International Chemistry Conference 

    Presentation date: 2022.12

    Event date:
    2022.12
     
     
  • フェノール類の酸化的脱芳香族化反応を活用した天然物合成

    小田木陽  [Invited]

    天然物化学談話会2021オンライン企画 

    Presentation date: 2021.09

  • Total Synthesis of Natural Product Based on Organocatalytic Reaction

    Minami Odagi  [Invited]

    JAIS Meeting in Florida 

    Presentation date: 2018.06

  • グアニジン—(チオ)ウレア触媒を用いた不斉反応を基盤とする天然物の合成研究

    小田木陽  [Invited]

    有機合成化学協会関東支部平成 29 年度若手研究者のためのセミナー 

    Presentation date: 2017.04

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Research Projects

  • Synthetic studies on highly oxidized daphnan diterpenes based on the light-promoted skeletal rearrangement of cross-conjugated dienones

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2025.04
    -
    2028.03
     

  • Synthetic Study of Hasubanan-type Alkaloids based on Oxidative Phenolic Coupling Reaction

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2020.04
    -
    2023.03
     

  • 酸化的環化反応を基盤としたモノテルペンインドールアルカロイド類の網羅的全合成

    Project Year :

    2018
    -
    2019
     

  • 有機触媒による速度論的光学分割を基盤とした光学活性テトラロン誘導体の合成法の開発

    Project Year :

    2016
    -
    2018
     

  • 有機触媒を用いた不斉酸化反応を基盤とする速度論的光学分割の開発と応用

    Project Year :

    2015
    -
    2016
     

Misc

  • 酸化的フェノールカップリングと分子内アザーマイケル反応を基盤としたHasubananアルカロイド類の合成研究”

    小田木陽

    有機合成化学協会誌    2023.12

    Authorship:Corresponding author

  • 脱芳香族化で拓く多環縮環型天然物の全合成 –戦略を以て、複雑天然物を制す!

    小田木陽

    化学と工業    2023.11

    Authorship:Corresponding author

  • 計算化学的手法を活用したグアニジンおよびウレア基を有する官能基複合型有機分子触媒による不斉酸化反応の開発

    小田木陽, 山中正浩

    有機合成化学協会誌    2023.07

    Authorship:Lead author, Corresponding author

  • タンパク質相互作用を理解する ー光触媒による局所ラベル化法の開発

    小田木陽, 長澤和夫

    化学    2023.06

    Authorship:Lead author, Corresponding author

  • Total Synthesis of Fused Polycyclic Alkaloids Based on Oxidative Phenolic Couplings and Aza-Michael Reactions

    Minami Odagi

    SYNLETT    2023.06

    Authorship:Lead author, Corresponding author

    DOI

  • Exploring Guanidinium Organocatalysts for Hypoiodite-Mediated Reactions

    Minami Odagi

    CHEMICAL RECORD    2023.03

    Authorship:Lead author, Corresponding author

    DOI PubMed

  • 戦略を以てトリカブト毒を制す アコニチン型アルカロイドの効率的合成

    小田木陽

    化学    2021.06

    Authorship:Corresponding author

  • Recent Advances in Synthetic Strategies for the C4a,C9a-Fused Tetracyclic Hydrocarbazole Core Structure of Minfiensine and Related Akuammiline Alkaloids

    Kazuo Nagasawa, Minami Odagi, Keisuke Hosoya, Keita Iida

    HETEROCYCLES   103 ( 1 ) 110 - 110  2021

    Authorship:Corresponding author

    DOI

  • Recent Advances in Natural Products Synthesis Using Bifunctional Organocatalysts Bearing a Hydrogen-Bonding Donor Moiety

    Odagi, M., Nagasawa, K.

    Asian Journal of Organic Chemistry   8 ( 10 )  2019.09  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

  • Synthetic studies of (23S,25R)-1α,25-dihydroxyvitamin D3 26,23-lactone (calcitriol lactone) and its derivatives

    Yusuke Akagi, Akiko Nagata, Minami Odagi, Kazuo Nagasawa

    Journal of Steroid Biochemistry and Molecular Biology   177   240 - 246  2018.03  [Refereed]

    DOI

  • Guanidine organocatalysis for enantioselective carbon-heteroatom bond-forming reactions

    Keisuke Hosoya, Minami Odagi, Kazuo Nagasawa

    Tetrahedron Letters   59 ( 8 ) 687 - 696  2018.02  [Refereed]

    Book review, literature introduction, etc.  

    DOI

  • Synthetic studies of (+) -gracilamine based on organocatalytic reaction

    Minami Odagi

    Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   76 ( 5 ) 434 - 437  2018  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

  • Construction of Quaternary Stereocenter based on Organocatalytic Dearomatization Reaction

    Odagi, Minami

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   75 ( 12 ) 1288 - 1289  2017.12  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI CiNii

  • TOTAL SYNTHESIS OF (+)-LINOXEPIN

    Minami Odagi, Kota Furukori, Yoshiharu Yamamoto, Kazuo Nagasawa

    HETEROCYCLES   95 ( 1 ) 116 - 126  2017.01  [Refereed]

    Authorship:Lead author, Corresponding author

    Book review, literature introduction, etc.  

    DOI

  • 触媒的不斉酸化反応にも大活躍!—進化する環境にやさしい超原子価ヨウ素試薬

    安井浩司, 小田木陽, 長澤和夫

    化学    2014.06

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Syllabus

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