Updated on 2024/12/21

写真a

 
HATTORI, Kaoru
 
Affiliation
Faculty of Science and Engineering, Graduate School of Advanced Science and Engineering
Job title
Associate Professor(non-tenure-track)
Degree
Phd (Medicine) ( 2017.03 Hirosaki University )
PhD (Biomedical Science) ( 2022.03 Waseda University & Tokyo Women's Medical University )

Research Experience

  • 2023.04
    -
    Now

    Waseda University   School of Advanced Science and Engineering   Associate Professor

  • 2022.06
    -
    2023.03

    Waseda University   Institute for Medical Regulatory Science   MD, Phd

  • 2020.01
    -
    2022.05

    大和成和病院   心臓血管外科

  • 2018.04
    -
    2019.12

    Tokyo Women's Medical University   Cardiovascular surgery   M.D., Ph.D.

  • 2016.04
    -
    2018.03

    青森市民病院   心臓血管外科

  • 2013.10
    -
    2016.03

    Hirosaki University

  • 2012.04
    -
    2013.09

    Hirosaki University

  • 2011.04
    -
    2012.03

    むつ総合病院   外科

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Education Background

  • 2019.04
    -
    2022.03

    Joint Graduate School of Tokyo Women's Medical University and Waseda University   Cooperative Major in Advanced Biomedical Sciences  

  • 2013.04
    -
    2017.03

    Hirosaki University School of Medicine  

  • 2003.04
    -
    2009.03

    Hirosaki University   Medicine   Medicine  

Professional Memberships

  • 　
    　
    　

    THE JAPANESE SOCIETY FOR HEART VALVE DISEASE

  • 　
    　
    　

    THE JAPANESE SOCIETY FOR CARDIOVASCULAR SURGERY

  • 　
    　
    　

    THE JAPANESE ASSOCIATION FOR THORACIC SURGERY

  • 　
    　
    　

    JAPAN SURGICAL SOCIETY

  • 　
    　
    　

    日本人工臓器学会

  • 　
    　
    　

    日本機械学会

  • 　
    　
    　

    日本循環器学会

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Research Areas

  • Cardiovascular surgery   bicuspid aortic valve

Research Interests

  • 医療レギュラトリーサイエンス

  • 循環器医工学

  • surgery for heart valve disease

  • bicuspid aortic valve

  • aortic valve

  • cardiovascular surgery

▼display all

 

Papers

  • 大動脈二尖弁の弁形態が上行大動脈に及ぼす影響 MRI対応型拍動循環回路を用いた大動脈血流評価

    服部 薫, 中間 菜月, 高田 淳平, 西村 剛毅, 森脇 涼, 川崎 瑛太, 長尾 充展, 後藤 康裕, 新浪 博士, 岩崎 清隆

    日本バイオレオロジー学会誌(B&R)   38 ( 2 ) 48 - 48  2024.06

  • A tissue-silicone integrated simulator for right ventricular pulsatile circulation with severe functional tricuspid regurgitation.

    Jumpei Takada, Hayato Morimura, Kohei Hamada, Yusei Okamoto, Shiho Mineta, Yusuke Tsuboko, Kaoru Hattori, Kiyotaka Iwasaki

    Scientific reports   14 ( 1 ) 5120 - 5120  2024.03  [International journal]

    　View Summary

    There is a great demand for development of a functional tricuspid regurgitation (FTR) model for accelerating development and preclinical study of tricuspid interventional repair devices. This study aimed to develop a severe FTR model by creating a tissue-silicone integrated right ventricular pulsatile circulatory simulator. The simulator incorporates the porcine tricuspid annulus, valve leaflets, chordae tendineae, papillary muscles, and right ventricular wall as one continuous piece of tissue, thereby preserving essential anatomical relationships of the tricuspid valve (TV) complex. We dilated the TV annulus with collagenolytic enzymes under applying stepwise dilation, and successfully achieved a severe FTR model with a regurgitant volume of 45 ± 9 mL/beat and a flow jet area of 15.8 ± 2.3 cm2 (n = 6). Compared to a normal model, the severe FTR model exhibited a larger annular circumference (133.1 ± 8.2 mm vs. 115.7 ± 5.5 mm; p = 0.009) and lower coaptation height (6.6 ± 1.0 mm vs. 17.7 ± 1.3 mm; p = 0.003). Following the De-Vega annular augmentation procedure to the severe FTR model, a significant reduction in regurgitant volume and flow jet area were observed. This severe FTR model may open new avenues for the development and evaluation of transcatheter TV devices.

    DOI PubMed

  • Relationships between bicuspid aortic valve morphology and hemodynamics

    Natsuki Nakama, Kaoru Hattori, Jumpei Takada, Eita Kawasaki, Kohei Hamada, Michinobu Nagao, Yasuhiro Goto, Hiroshi Niinami, Kiyotaka Iwasaki

      150 ( 2 ) PS177  2021.10

  • An adolescent with Behcet’s aortitis mimicking infective endocarditis: a case report

    Kaoru Hattori, Mimiko Tabata, Tohru Nojiri, Atsushi Kurata

    Eur Heart J Case Rep   5 ( 10 ) ytab315  2021.10  [Refereed]

  • Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system

    Kaoru Hattori, Natsuki Nakama, Jumpei Takada, Gohki Nishimura, Ryo Moriwaki, Eita Kawasaki, Michinobu Nagao, Yasuhiro Goto, Hiroshi Niinami, Kiyotaka Iwasaki

    Sci Rep   11 ( 1 )  2021.01  [Refereed]

    DOI

  • 大動脈二尖弁形態が大動脈血流に及ぼす影響 流線、流速、渦度の評価が可能な4D-MRI対応型拍動循環回路の開発

    服部 薫, 中間 菜月, 高田 淳平, 西村 剛毅, 森脇 涼, 川崎 瑛太, 長尾 充展, 後藤 康裕, 新浪 博士, 岩崎 清隆

    人工臓器   49 ( 2 ) S - 123  2020.10

  • Surgical embolectomy for paradoxical cerebral embolism with massive pulmonary embolism

    Kaoru Hattori, Kazuyuki Daitoku, Satoshi Taniguchi, Ikuo Fukuda

    Gen Thorac Cardiovasc Surg   68 ( 4 ) 385 - 388  2020.04  [Refereed]

  • Pseudoaneurysm of abumominal aorta associated with PAU: a case report

    Nobuaki Suzuki, Ryo Taguchi, Kensuke Murata, Kaoru Hattori, Masaharu Hatakeyama, Kazuo ito, Tomomi Kusumi, Kozo Fukui

    Heart   52 ( 9 ) 1044 - 1048  2020  [Refereed]

  • 大動脈二尖弁の弁形態が上行大動脈血流へ及ぼす影響 MRIに適応可能な拍動循環回路を用いた上行大動脈の血流評価

    服部 薫, 高田 淳平, 熊澤 亮, 西村 剛毅, 森脇 涼, 中間 菜月, 川崎 瑛太, 長尾 充展, 後藤 康裕, 新浪 博士, 岩崎 清隆

    人工臓器   48 ( 2 ) S - 225  2019.10

  • Pulsatile flow test on the influence on the commissure orientation on the hydrodynamic performance of the bicuspid aortic valve

    Jumpei Takada, Kaoru Hattori, Ryo Kumazawa, Gohki Nishimura, Ryo Moriwaki, Mitsuo Umezu, Kiyotaka Iwasaki

    The proceedings of the Bioengineering conference   32  2019.01

  • Management of pulmonary thromboembolism based on severity and vulnerability to thrombosis

    Wakako Fukuda, Satoshi Taniguchi, Ikuo Fukuda, Kaoru Hattori, Mari Chiyoya, Chikashi Aoki, Norihiro Kondo, Kazuyuki Daitoku, Ryosuke Kowatari, Masahito Minakawa, Yasuyuki Suzuki

    Ann Vasc Dis   10 ( 4 ) 371 - 377  2017.12  [Refereed]

  • Rate of Stenotic Bicuspid Aortic Valve Aortic Dilatation After Aortic Valve Replacement, Calculated Using a 3-Dimensional Reconstruction Tool

    Kaoru Hattori, Ikuo Fukuda, Kazuyuki Daitoku, Masahito Minakawa, Hiroyuki Itaya

    CIRCULATION JOURNAL   81 ( 8 ) 1207 - 1212  2017.08  [Refereed]

    　View Summary

    Background: Progression of asymmetric dilated aorta associated with bicuspid aortic valve (BAV) is difficult to evaluate conventionally. The aim of the study was to calculate the rate of progression of the dilated BAV aorta after aortic valve replacement (AVR) using a 3-dimensional (3-D) reconstruction tool.
    Methods and Results: Fourteen stenotic BAV and 14 stenotic tricuspid aortic valve (TAV) patients with mildly dilated ascending aorta were reviewed. A patient-specific 3-D aortic model was reconstructed from preoperative and postoperative computed tomography data (BAV, 2.5 +/- 1.9 years after AVR; TAV, 2.2 +/- 1.8 years after AVR). Aortic diameter, including the longest and shortest, was measured on the maximum perpendicular cross-section tangential to the 3-D centerline of the reconstructed model. The longest diameter was defined as that passing through the distal point of the greater curvature of the aorta. The shortest diameter was defined as perpendicular to the longest. The progression rates were compared between the BAV and TAV groups. The progression rate of ascending aortic diameter was greater for BAV (longest diameter, 1.02 +/- 1.03 vs. -0.075 +/- 0.78 mm/year, P<0.001; shortest diameter, 0.41 +/- 0.62 vs. -0.016 +/- 0.59 mm/year, P=0.003). The longest diameter of the proximal arch also grew more rapidly in the BAV group (P<0.001).
    Conclusions: Ascending aortic dilatation with stenotic BAV progresses after AVR at a maximum rate of 1.02 +/- 1.03 mm/year. Expansion toward the greater curvature frequently progresses to the proximal arch.

    DOI

  • Posteromedial papillary muscle rupture due to squeezing of the left anterior descending coronary artery

    Kaoru Hattori, Kozo Fukui, Nobuaki Suzuki, Kazuo Ito

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   24 ( 4 ) 636 - 638  2017.04  [Refereed]

    　View Summary

    An unusual case of posteromedial papillary muscle (PPM) rupture due to isolated left anterior descending ( LAD) artery ischaemia, associated with severe myocardial bridge contraction, is presented. The unusual blood supply to the PPM was associated with its apical origin and apex-forming LAD.

    DOI

  • A novel surgical procedure for scimitar syndrome: scimitar vein with right atrium and inferior vena cava wall flap

    Ryosuke Kowatari, Yasuyuki Suzuki, Kazuyuki Daitoku, Kaoru Hattori, Ikuo Fukuda

    JOURNAL OF CARDIAC SURGERY   31 ( 10 ) 642 - 644  2016.10  [Refereed]

    　View Summary

    We describe a new surgical procedure for the scimitar syndrome using the walls of the right atrium and inferior vena cava as a flap to prevent kinking and stenosis of the scimitar vein-left atrium anastomosis.

    DOI

  • Jpn J Phlebol 27(2): p.53-59、2016

    Wakako Fukuda, Satoshi Taniguchi, Ikuo Fukuda, Kaoru Hattori, Mari Chiyoya, Chikashi Aoki, Norihiro Kondo, Kazuyuki Daitoku, Ryosuke Kowatari, Masahito Minakawa, Yasuyuki Suzuki

      27 ( 2 ) 53 - 59  2016

  • Surgery for infective endocarditis involving valve annulus

    Kazuyuki Daitoku, Kaoru Hattori, Wakako Fukuda, Masahito Minakawa, Ikuo Fukuda

      10 ( 4 ) 371 - 377  2015.11

  • Novel Method of Assessing Ascending Aorta with a Stenotic Bicuspid Aortic Valve

    Kaoru Hattori, Ikuo Fukuda, Kazuyuki Daitoku, Wakako Fukuda, Masahito Minakawa, Yasuyuki Suzuki

    JOURNAL OF HEART VALVE DISEASE   24 ( 5 ) 554 - 559  2015.09  [Refereed]

    　View Summary

    Background and aim of the study: Patients with bicuspid aortic valve (BAV) have an increased risk of serious aortic complications such as aortic dissection, rupture and dilatation of the ascending aorta. Previous findings have suggested that ascending aortic dilatation with a BAV has a typical asymmetric configuration at the right-anterior aspect of the aorta. The study aim was to quantify asymmetric configurations of the aorta using a three-dimensional (3D) reconstruction tool.
    Methods: A retrospective review was conducted of 52 patients (27 males, 25 females; mean age 69 9 years) with aortic stenosis who presented with ascending aortic dilatation defined as an aortic diameter >35 mm. Of these patients, 24 (46%) had a BAV and 28 (54%) had a tricuspid aortic valve (TAV). A patient-specific 3D thoracic aortic model was reconstructed from computed tomography (CT) data. Three-dimensional centerlines were automatically calculated. The size of the ascending aorta was determined by calculating the cross-sectional area (in mm(2)) of the vertical section against the centerline. The symmetry of the dilated aorta was evaluated as the ellipticity of the maximum vertical section of the ascending aorta. The size and symmetry of the ascending aorta, and background factors including pressure gradient, aortic valve area, degree of regurgitation, ejection fraction and cardiovascular risk factors, were compared between the BAV and TAV groups.
    Results: Only age differed significantly between the groups (p = 0.003). The size and ellipticity of the ascending aorta and the maximum cross-sectional area of the aortic arch were significantly greater in the BAV group (p = 0.001 and p = 0.004, respectively).
    Conclusion: The ascending aorta assessed using Mimics 3D reconstruction software was frequently asymmetrically dilated in stenotic BAV, and the expansion progressed to the aortic arch. It is believed that calculating the ellipticity of the vertical section against the centerline offers an innovative means of quantifying aortic symmetry in three dimensions.

  • The efficacy of conventional aortic valve replacement for severe aortic valve stenosis divided by risk classification using the Japanese scoring system

    Kazuyuki Daitoku, Kaoru Hattori, Wakako Fukuda, Norihiro Kondo, Satoshi Taniguchi, Masahito Minakawa, Kozo Fukui, Yasuyuki Suzuki, Ikuo Fukuda

    Japanese journal of Cardiovascular surgery   43 ( 2 ) 43 - 48  2014  [Refereed]

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Presentations

  • MRI対応型拍動循環システムを用いた大動脈二尖弁と上行大動脈血流の評価

    服部 薫

    第45回日本バイオレオロジー学会年会 

    Presentation date： 2022.06

    Event date：
    2022.06
    -
    　

  • Bicuspid aortic valve morphology and aortic hemodynamics: an experimental Analysis using an MRI-compatible pulsatile flow circulation system

    Kaoru Hattori

    CARS 2022 

    Presentation date： 2022.06

    Event date：
    2022.06
    -
    　

  • 4D-MRIを用いた大動脈二尖弁の形態と上行大動脈拡大の評価

    服部 薫

    第86回日本循環器学会学術集会 (日本機械学会合同シンポジウム) 

    Presentation date： 2022.03

    Event date：
    2022.03
    -
    　

  • 大動脈二尖弁と上行大動脈拡大リスク

    服部 薫

    ARIA 2021 

    Presentation date： 2021.11

    Event date：
    2021.11
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  • Experimental analysis of aortic valve hemodynamics: effect of mild aortic dilatation on systolic flow characteristics

    Kaoru Hattori

    Scientific Session of AHA 2021 

    Presentation date： 2021.11

  • 大動脈二尖弁が収縮期血流に及ぼす影響

    服部 薫

    ARIA 2020 

    Presentation date： 2020.11

    Event date：
    2020.11
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  • 大動脈二尖弁形態が大動脈血流に及ぼす影響～流線、流速、渦度の評価が可能な4D-MRI対応型 拍動循環回路の開発

    服部 薫

    第58回人工臓器学会大会 

    Presentation date： 2020.11

    Event date：
    2020.11
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  • Bicuspid aortic valve morphology and risk factors of abnormal hemodynamics: an experimental investigation of velocity, vorticity and eccentricity of systolic jet stream, using a Magnetic Resonance Imaging compatible pulsatile flow circulation system

    kaoru Hattori

    Scientific Session of AHA 2020 

    Presentation date： 2020.11

    Event date：
    2020.11
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  • 大動脈二尖弁形態が上行大動脈に及ぼす影響～大動脈弁モデルとMRI対応型拍動循環回路を 用いた上行大動脈血流の評価～

    服部 薫

    第73回日本胸部外科学会定期学術集会 

    Presentation date： 2020.10

    Event date：
    2020.10
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  • Four-dimensional flow MRI assessment of valvular flow characteristics: systolic flow pattern, direction and velocity of supra-valvular jet in experimental bicuspid aortic valve

    Kaoru hattori

    17th ICBME 

    Presentation date： 2019.12

    Event date：
    2019.12
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  • 大動脈二尖弁の弁癒合形態が上行大動脈の血流形態に及ぼす影響～実験モデルと4D-MRIを用いた 上行弓部大動脈の血流評価～

    服部 薫

    第57回人工臓器学会大会 

    Presentation date： 2019.11

    Event date：
    2019.11
    -
    　

  • Relationships between bicuspid aortic valve morphology and hemodynamics: an experimental investigation of flow, leakage, and supra-valvular jet using a pulsatile flow circulation system and Magnetic Resonance Imaging

    Kaoru Hattori

    Scientific Session of AHA 2019 

    Presentation date： 2019.11

    Event date：
    2019.11
    -
    　

  • 大動脈弁モデルと拍動循環シミュレータを用いた大動脈二尖弁の弁機能評価

    服部 薫

    第72回日本胸部外科学会定期学術集会 

    Presentation date： 2019.10

    Event date：
    2019.10
    -
    　

  • Bicuspid aortic valve morphology and aortic hemodynamics

    Kaoru Hattori

    Presentation date： 2019.06

    Event date：
    2019.06
    -
    　

  • 活動期感染性心内膜炎の手術成績と危険予測因子の検討

    服部 薫

    第9回日本弁膜症学会 

    Presentation date： 2018.12

    Event date：
    2018.12
    -
    　

  • 高齢者大動脈弁狭窄症に対するSAVRの手術成績と危険予測因子の検討

    服部 薫

    第48回日本心臓血管外科学会学術総会 

    Presentation date： 2018.02

  • 透析AS患者に対する手術成績と主要合併症の術前危険予測因子

    服部 薫

    第47回日本心臓血管外科学会学術総会 

    Presentation date： 2017.02

    Event date：
    2017.02
    -
    　

  • 若年で進行する二尖大動脈弁狭窄の危険予測因子

    服部 薫

    第69回日本胸部外科学会学術総会 

    Presentation date： 2016.10

  • 二尖大動脈弁狭窄におけるAVR術後の上行大動脈径の変化

    服部 薫

    第68回日本胸部外科学会学術総会 

    Presentation date： 2015.10

  • 三次元モデル作成ソフトを用いた、二尖大動脈狭窄における上行大動脈拡大の形態評価

    服部 薫

    第67回日本胸部外科学会学術総会 

    Presentation date： 2014.10

  • Novel method of assessment for ascending aortic dilatation with the bicuspid aortic valve

    Kaoru Hattori

    28th European Association for Cardio-Thoracic Surgery 

    Presentation date： 2014.10

  • 体格の小さい高齢女性に対する人工弁の選択

    服部 薫

    第44回日本心臓血管外科学会学術総会 

    Presentation date： 2014.02

  • 二尖弁大動脈弁狭窄における大動脈弁置換術後の胸部大動脈径の変化

    服部 薫

    第66回日本胸部外科学会定期学術集会 

    Presentation date： 2013.10

  • 部分体外循環を用いた乳幼児早期大動脈縮窄(離断)の手術

    服部 薫

    第49回日本小児循環器学会総会・学術集会 

    Presentation date： 2013.07

    Event date：
    2013.07
    -
    　

  • 大動脈弁狭窄が上行大動脈径に与える影響:二尖大動脈弁と三尖弁の背景因子の検討

    服部 薫

    第43回日本心臓血管外科学会学術総会 

    Presentation date： 2013.02

  • 心室中隔穿孔の短期手術成績と術前・術中予測因子および術式の検討

    服部 薫

    第65回日本胸部外科学会定期学術集会 

    Presentation date： 2012.10

    Event date：
    2012.10
    -
    　

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Research Projects

  • 右心室組織ハイブリッド循環シミュレータを用いた新たな三尖弁治療デバイスの提案

    日本学術振興会  科学研究費助成事業

    Project Year :

    2023.04
    -
    2026.03
     

    高田 淳平, 森村 隼人, 岩崎 清隆, 服部 薫, 坪子 侑佑

  • Novel classification system for assesing risk of progressive ascending aortic dialation associated with bicuspid aortic valve

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2019.04
    -
    2022.03
     

    Hattori Kaoru

    　View Summary

    In this study, morphotype-specific valve-devising apparatuses was developed to create aortic valve models, and an MRI-compatible pulsatile flow circulation system was developed to quantify the aortic valvular outflow jet. This study elucidated that bicuspid symmetry and the position of smaller leaflet were determinant factors of the characteristics of aortic valvular outflow jet.

Misc

  • Development of the circulatory simulator for generating coronary hemodynamics with microcirculation

    池原大烈, 坪子侑佑, 松原海斗, 服部薫, 新浪博士, 岩崎清隆

    日本生体医工学会大会プログラム・抄録集(Web)   59th ( Abstract ) 391 - 391  2020

    　View Summary

    The left anterior descending coronary artery (LAD) compliance and hemodynamics changes after coronary artery bypass grafting and percutaneous coronary intervention are unclear. We have been developing a mock circulatory system for reproducing coronary hemodynamics including microcirculation. In this study, we newly developed the controlling mechanism of coronary vascular resistance. The simulator consists of roller pomp, silicone-made LAD and microvascular model, check valve and compliance tubing. We developed the linear motion mechanism for the reproduction of fluctuation of peripheral coronary artery resistance following ventricular contraction. As a result of the synchronization of two types of actuators, we obtained physiological coronary hemodynamics with 130/80(96) mmHg of the pressure and 370 ml/min of the mean flow rate. The simulated pressure waveform showed characteristic bimodal and large diastolic peak. For more sophisticated simulation, we are preparing the reproduction of interaction between coronary and systemic circulation and improving the controlling mechanism of coronary vascular resistance.

    DOI CiNii J-GLOBAL

  • Development of pulsatile circulatory system for measuring ascending aorta hemodynamics with 4D-MRI

    中間菜月, 服部薫, 服部薫, 高田淳平, 西村剛毅, 森脇涼, 川崎瑛太, 長尾充展, 後藤康裕, 坪子侑佑, 岩崎清隆, 岩崎清隆, 岩崎清隆

    日本生体医工学会大会プログラム・抄録集(Web)   59th ( Abstract ) 386 - 386  2020

    　View Summary

    Bicuspid aortic valve disease is a common congenital valvular disease. There are several variations in valve morphology and its relationship with ascending aortic dilation is not clear. In this study, we newly developed a pulsatile circulatory system to investigate flow in ascending aorta using 4D-MRI. The simulator consists of the silicone-made left ventricle, aortic valve chamber, aortic arch, compliance tank, and reservoir. The aortic valve model was fabricated using bovine aorta and pericardium and installed in the valve chamber. Pulsatile pressure and flow were pneumatically generated and controlled by peripheral resistive unit. A tricuspid aortic valve model was investigated by 4D-MRI. In the ascending aorta, straight flow was observed in early-systole and physiological clockwise-twisted flow was observed in late-systole respectively. Therefore, the pulsatile circulatory system developed in this study can be useful for revealing the relationship between bicuspid valve morphology and flow pattern in ascending aorta.

    DOI CiNii J-GLOBAL

 

Syllabus

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Research Institute

  • 2023
    -
    2024

    Waseda Research Institute for Science and Engineering   Concurrent Researcher

Internal Special Research Projects

  • 大動脈解離モデルを用いたhigh-risk uncomplicated B型解離の解剖学的特徴の解析

    2023  

    　View Summary

    　重篤な合併症を伴わない Stanford B型 大動脈解離の標準的治療は保存的降圧療法であるが，25% の症例では慢性期に偽腔の拡大が進行し，時として大動脈破裂で死亡する．このような高リスク症例には，偽腔拡大が顕在化する前にステントグラフトでエントリーを閉鎖する先制的ステントグラフト治療が推奨されている．しかし、現時点では慢性期の偽腔拡大を予測する上で必要十分な臨床的指標がなく，高リスク型の予測診断および至適時期での先制的ステントグラフト治療は困難な状況にある．本研究では，高リスク型B型大動脈解離の解剖学的特徴を明らかにするため，① 弓部大動脈の走行の「捻れ」，② 下行大動脈の「屈曲」をパラメータとするB型大動脈解離の病態シミュレータを開発し，これらのパラメータが偽腔内流れに及ぼす影響を 4D-flow MRI で定量的に分析した．評価項目は，エントリー流入速度，エントリー流量，偽腔内流れの流速・循環，偽腔壁に作用する壁せん断応力とした．本年度は①弓部大動脈の走行の「捻れ」が異なる2種類のStanford B型大動脈解離モデルを作製し，大動脈解離患者の血行動態（心拍出量5L/min, 平均大動脈圧 100mmHg, 左室収縮期圧150 mmHg）を創出する拍動循環シミュレータを構築して，弓部大動脈の走行の「捻れ」が偽腔壁に作用する壁せん断応力の関連因子であることを明らかにした． 　本研究成果は，第46回日本バイオレオロジー学会年会，第61回日本人工臓器学会大会で発表した．

  • 4D-MRIを用いた大動脈解離モデルの偽腔内血流評価に関する研究

    2023  

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    重篤な合併症を伴わない Stanford B型 大動脈解離の標準的治療は保存的降圧療法であるが，25% の症例では慢性期に偽腔の拡大が進行し，時として大動脈破裂で死亡する．このような高リスク症例には，偽腔拡大が顕在化する前にステントグラフトでエントリーを閉鎖する先制的ステントグラフト治療が推奨されている．しかし、現時点では慢性期の偽腔拡大を予測する上で必要十分な臨床的指標がなく，高リスク型の予測診断および至適時期での先制的ステントグラフト治療は困難な状況にある．本研究では，高リスク型B型大動脈解離の解剖学的特徴を明らかにするため，① 弓部大動脈の走行の「捻れ」，② 下行大動脈の 「屈曲」をパラメータとするB型大動脈解離の病態シミュレータを開発し，これらのパラメータが偽腔内流れに及ぼす影響を 4D-flow MRI で定量的に分析した．評価項目は，エントリー流入速度，エントリー流量，偽腔内流れの流速・循環，偽腔壁に作用する壁せん断応力とした．本年度は①弓部大動脈の走行の「捻れ」が異なる2種類のStanford B型大動脈解離モデルを作製し，大動脈解離患者の血行動態（心拍出量 5L/min, 平均大動脈圧 100mmHg, 左室収縮期圧 150 mmHg）を創出する拍動循環シミュレータを構築して，弓部大動脈の走行の「捻れ」が偽腔壁に作用する壁せん断応力の関連因子であることを明らかにした．本研究成果は，第46回日本バイオレオロジー学会年会，第61回日本人工臓器学会大会で発表した．