Updated on 2022/07/02

写真a

 
WATANABE, Daiki
 
Affiliation
Faculty of Sport Sciences, School of Sport and Sciences
Job title
Assistant Professor(without tenure)

Education

  • 2016.04
    -
    2020.03

    St. Marianna University School of Medicine   Graduate School of Medicine Medical Research Division   Department of Clinical Pharmacology  

  • 2013.04
    -
    2015.03

    Kanagawa University of Human Services Graduate School   Graduate Course of Health and Social Services   Nutrition  

  • 2009.04
    -
    2013.03

    Jin-ai University   Faculty of Human Life   Department of Health and Nutrition  

Degree

  • 2020.03   聖マリアンナ医科大学   博士(医学)

  • 2015.03   神奈川県立保健福祉大学   修士(栄養学)

Research Experience

  • 2022.04
    -
    Now

    Waseda University   Faculty of Sport Sciences   Assistant professor

  • 2022.04
    -
    Now

    National Institutes of Biomedical Innovation, Health and Nutrition   Department of Physical Activity Research, National Institute of Health and Nutrition   Collaborative Researcher

  • 2020.04
    -
    Now

    Kyoto University of Advanced Science   Institute for Active Health   Visiting scholar

  • 2019.05
    -
    2022.03

    National Institutes of Biomedical Innovation, Health and Nutrition   Section of Healthy Longevity Research   Postdoctoral fellow

  • 2018.04
    -
    2019.04

    National Institutes of Biomedical Innovation, Health and Nutrition   Section of Healthy Longevity Research   Technical assistant

  • 2015.04
    -
    2016.03

    Kanagawa University of Human Services   Department of Nutrition and Dietetics   Assistant

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Professional Memberships

  • 2019.04
    -
    Now

    日本公衆衛生学会

  • 2019.02
    -
    Now

    国際キンアンソロポメトリー推進学会

  • 2019.01
    -
    Now

    日本疫学会

  • 2018.08
    -
    Now

    日本静脈経腸栄養学会

  • 2014.04
    -
    Now

    日本臨床栄養学会

  • 2014.02
    -
    Now

    日本栄養改善学会

▼display all

 

Research Areas

  • Nutrition science and health science

  • Hygiene and public health (laboratory)

  • Hygiene and public health (non-laboratory)

Research Interests

  • 身体活動

  • Lifestyle disease

  • Gut microbiome

  • Frailty

  • Nutritional epidemiology

Papers

  • Validation of the Kihon Checklist and the frailty screening index for frailty defined by the phenotype model in older Japanese adults

    Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

    BMC Geriatrics   22 ( 1 ) 478  2022.06  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    Abstract

    Background

    The term “frailty” might appear simple, but the methods used to assess it differ among studies. Consequently, there is inconsistency in the classification of frailty and predictive capacity depending on the frailty assessment method utilised. We aimed to examine the diagnostic accuracy of several screening tools for frailty defined by the phenotype model in older Japanese adults.

    Methods

    This cross-sectional study included 1,306 older Japanese adults aged ≥ 65 years who underwent physical check-up by cluster random sampling as part of the Kyoto-Kameoka Study in Japan. We evaluated the diagnostic accuracy of several screening instruments for frailty using the revised Japanese version of the Cardiovascular Health Study criteria as the reference standard. These criteria are based on the Fried phenotype model and include five elements: unintentional weight loss, weakness (grip strength), exhaustion, slowness (normal gait speed), and low physical activity. The Kihon Checklist (KCL), frailty screening index (FSI), and self-reported health were evaluated using mailed surveys. We calculated the non-parametric area under the receiver operating characteristic curve (AUC ROC) for several screening tools against the reference standard.

    Results

    The participants’ mean (standard deviation) age was 72.8 (5.5) years. The prevalence of frailty based on the Fried phenotype model was 12.2% in women and 10.3% in men. The AUC ROC was 0.861 (95% confidence interval: 0.832–0.889) for KCL, 0.860 (0.831–0.889) for FSI, and 0.668 (0.629–0.707) for self-reported health. The cut-off for identifying frail individuals was ≥ 7 points in the KCL and ≥ 2 points in the FSI.

    Conclusions

    Our results indicated that the two instruments (KCL and FSI) had sufficient diagnostic accuracy for frailty based on the phenotype model for older Japanese adults. This may be useful for the early detection of frailty in high-risk older adults.

    DOI

  • Dose-Response Relationship Between Life-Space Mobility and Mortality in Older Japanese Adults: A Prospective Cohort Study.

    Daiki Watanabe, Tsukasa Yoshida, Yosuke Yamada, Yuya Watanabe, Minoru Yamada, Hiroyuki Fujita, Tomoki Nakaya, Motohiko Miyachi, Hidenori Arai, Misaka Kimura

    Journal of the American Medical Directors Association    2022.05  [Refereed]  [International journal]

    Authorship:Lead author, Corresponding author

     View Summary

    OBJECTIVES: Some epidemiological studies of older American adults have reported a relationship between life-space mobility (LSM) and mortality. However, these studies did not show a dose-response relationship and did not include individuals from other countries. Therefore, we evaluated the dose-response relationship between LSM and mortality in older adults. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: We used the data of 10,014 older Japanese adults (aged ≥65 years) who provided valid responses to the Life-Space Assessment (LSA) in the Kyoto-Kameoka study in Japan. METHODS: LSM was evaluated using the self-administered LSA consisting of 5 items regarding life-space from person's bedroom to outside town. The LSM score was calculated by multiplying life-space level by frequency score by independence score, yielding a possible range of 0 (constricted life-space) to 120 (broad life-space). These scores were categorized into quartiles (Qs). Mortality data were collected from July 30, 2011 to November 30, 2016. A multivariate Cox proportional hazards model that included baseline covariates were used to evaluate the relationship between LSM score and mortality risk. RESULTS: A total of 1030 deaths were recorded during the median follow-up period of 5.3 years. We found a negative association between LSM score and overall mortality even after adjusting for confounders [Q1: reference; Q2: hazard ratio (HR) 0.81, 95% CI 0.69-0.95; Q3: HR 0.70, 95% CI 0.59-0.85; Q4: HR 0.68, 95% CI 0.55-0.84, P for trend < .001]. Similar results were observed for the spline model; up to a score of 60 points, LSM showed a strong dose-dependent negative association with mortality, but no significant differences were observed thereafter (L-shaped relationship). CONCLUSIONS AND IMPLICATIONS: Our findings demonstrate an L-shaped relationship between LSM and mortality. This study will be useful in establishing target values for expanding the range of mobility among withdrawn older adults with a constricted life-space.

    DOI PubMed

  • Weight over-reporting is associated with low muscle mass among community-dwelling Japanese adults aged 40 years and older: a cross sectional study.

    Takashi Nakagata, Tsukasa Yoshida, Daiki Watanabe, Yukako Arishima-Hashii, Yosuke Yamada, Naomi Sawada, Hidekazu Shimada, Nobuo Nishi, Motohiko Miyachi

    Journal of physiological anthropology   41 ( 1 ) 19 - 19  2022.05  [Refereed]  [International journal]

     View Summary

    BACKGROUND: Weight misperception adversely affects health-related quality of life (HRQol); however, few studies have evaluated the relationship between weight misperception and muscle mass. This study aimed to examine the relationship of weight misperception with low muscle mass using skeletal muscle index (SMI) estimated by multifrequency bioelectrical impedance analysis (MF-BIA) among community-dwelling Japanese. METHODS: Participants were 525 Japanese individuals aged 40-91 years old (male 89, female 436). Misperception was calculated by subtracting measured value from self-reported weight, presented as a percentage and categorized into tertiles based on sex (under-reporters, acceptable reporters, and over-reporters). Appendicular lean mass was estimated using MF-BIA, and low muscle mass was defined using SMI values of 7.0 and 5.7 kg/m2 for males and females, respectively, based on the Asian Working Group for Sarcopenia 2019 consensus. We evaluated the association between prevalence of low muscle mass and weight misperception (under-reporters and over-reporters) using multivariate logistic regression including covariate. RESULTS: In total, 9.3% (49/525) of participants had low muscle mass. After adjusting for covariates, prevalence of low muscle mass was higher among over-reporters than acceptable-reporters (odds ratio [OR]; 2.37, 95% confidence interval [CI]; 1.03-5.44). Additionally, sensitivity analysis was performed on females, which confirmed that the prevalence of low muscle mass was higher in over-reporters than in acceptable-reporters (OR, 3.27; 95% CI, 1.18-9.12). CONCLUSION: Weight misperception was significantly correlated with low muscle mass, especially in over-reporters.

    DOI PubMed

  • Diet quality and physical or comprehensive frailty among older adults.

    Daiki Watanabe, Kayo Kurotani, Tsukasa Yoshida, Hinako Nanri, Yuya Watanabe, Heiwa Date, Aya Itoi, Chiho Goto, Kazuko Ishikawa-Takata, Misaka Kimura, Motohiko Miyachi, Yosuke Yamada

    European journal of nutrition    2022.02  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    PURPOSE: While the association between diet quality and mortality has been previously demonstrated, the association between frailty and diet quality has not been evaluated well. This study aimed to investigate the association between diet quality and prevalence of both physical and comprehensive frailty, using two validated tools, in a community-based cohort of older adults. METHODS: We conducted cross-sectional analyses using baseline data of 7022 participants aged ≥ 65 years in the Kyoto-Kameoka study. Diet quality was assessed by calculating the adherence scores to the Japanese Food Guide Spinning Top using a validated questionnaire; the participants were stratified into quartile groups based on these scores. Physical and comprehensive frailty was assessed using the Fried phenotype model-based Frailty Screening Index and the Kihon Checklist, respectively. Multivariable logistic regression and the restricted cubic spline model were used to calculate odds ratios (ORs) and their 95% confidence intervals (CIs) for associations between adherence scores and frailty prevalence. RESULTS: Higher adherence scores signified a higher intake of vitamin C, vegetables, dairy products, and fruits. Physical and comprehensive frailty prevalence was 14.2 and 35.8%, respectively. In a multivariable adjusted model, compared with the bottom adherence score quartile, the top quartile was associated with lower ORs of physical (OR 0.64; 95% CI 0.52-0.80) and comprehensive frailty (OR 0.60; 95% CI 0.51-0.71). These relationships were similar to results in the spline model. CONCLUSIONS: This study shows an inverse dose-response relationship between diet quality and prevalence of both physical and comprehensive frailty in older adults.

    DOI PubMed

  • Association Between Temporal Changes in Diet Quality and Concurrent Changes in Dietary Intake, Body Mass Index, and Physical Activity Among Japanese Adults: A Longitudinal Study

    Daiki Watanabe, Haruka Murakami, Yuko Gando, Ryoko Kawakami, Kumpei Tanisawa, Harumi Ohno, Kana Konishi, Azusa Sasaki, Akie Morishita, Nobuyuki Miyatake, Motohiko Miyachi

    Frontiers in Nutrition   9  2022.02  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    <sec><title>Background</title>Many cross-sectional studies have identified modifiable factors such as dietary intake, physique, and physical activity associated with diet quality but were unable to determine how a specific individual's diet quality changes with these factors. These relationships may vary depending on an individual's dietary intake. We aimed to determine the association between temporal changes in diet quality and concurrent changes in dietary intake, body mass index (BMI), and physical activity according to the diet quality trajectory pattern.

    </sec><sec><title>Methods</title>This longitudinal prospective study included 697 Japanese adults aged 26–85 years, at baseline, with available data from at least two dietary intake surveys (4,118 measurements). Dietary intake and physical activity were evaluated using validated dietary questionnaires and a triaxial accelerometer. Diet quality was calculated using the Nutrient-Rich Food Index 9.3 (NRF9.3), while physical activity was calculated based on the duration of activity performed at each level of intensity (sedentary, light, moderate, and vigorous). Body mass index was calculated from the measured height and weight. Statistical analyses involved latent class growth models (LCGM) and random-effect panel data analysis.

    </sec><sec><title>Results</title>During a mean follow-up period of 6.8 years, NRF9.3 scores were assessed, on average, 5.4 times in men and 6.1 times in women. Based on the NRF9.3 score, three separate trajectory groups—“low-increasing,” “medium-increasing,” and “high-stable”—among individuals aged 26–90 years were identified using LCGM. In the multivariate analysis, the NRF9.3 score trajectory was positively associated with intake of energy, protein, dietary fiber, vitamins A and C, magnesium, and food items, such as fruits and vegetables, and was negatively associated with BMI and the intake of added sugar, saturated fats, sodium, and food items, such as meat and sugar and confectioneries, even after adjusting for covariates. These relationships displayed heterogeneity across the identified NRF9.3 score trajectory groups. In the low-increasing group, an inverse relationship was observed between sedentary behavior and NRF9.3 score trajectory.

    </sec><sec><title>Conclusions</title>We identified modifiable factors associated with temporal changes in diet quality across a wide age range; however, these factors may vary according to the diet quality trajectories. Our findings may help develop effective strategies for improving diet quality, according to the trajectory of diet quality.

    </sec>

    DOI

  • Adequate Protein Intake on Comprehensive Frailty in Older Adults: Kyoto-Kameoka Study.

    H Nanri, D Watanabe, T Yoshida, E Yoshimura, Y Okabe, M Ono, T Koizumi, H Kobayashi, H Fujita, M Kimura, Y Yamada

    The journal of nutrition, health & aging   26 ( 2 ) 161 - 168  2022.02  [Refereed]  [International journal]

     View Summary

    OBJECTIVES: Defining an adequate protein intake in older adults remains unresolved. We examined the association between calibrated protein intake and comprehensive frailty by sex in the Kyoto-Kameoka study. DESIGN: Cross-sectional study of baseline data. SETTING AND PARTICIPANTS: The study included 5679 Japanese participants aged 65 years or older. METHODS: Calibration coefficients were estimated from food frequency questionnaires and 7-day dietary records as a reference. Comprehensive frailty was evaluated using the 25-item Kihon Checklist (KCL) and defined as a total KCL score of ≥7points. Sex-specific calibrated protein intakes were presented as % of energy, per kg of actual body weight (BW), and per kg of ideal BW. RESULTS: Multiple logistic regression analysis showed that calibrated protein intake is inversely associated with comprehensive frailty. The association between protein intake and comprehensive frailty was also evaluated using curve fitting with non-linear regression, a weak U-shaped association was found in males and an L-shaped association in females. Men had a low prevalence of frailty at a calibrated protein intake of 15-17% energy from protein, 1.2 g/kg actual BW/day, or 1.4 g/kg ideal BW/day, and women had a low prevalence of frailty at 17-21% energy from protein or 1.6 g/kg ideal BW/day, with the prevalence of frailty remaining unchanged at higher protein intakes. Meanwhile, the inverse relationship between protein intake per ABW and frailty showed a gradual decrease at 1.4 g/kg ABW/day for protein in women. CONCLUSIONS AND IMPLICATIONS: A non-linear relationship was found between calibrated protein intake and frailty, with a U-shaped association in men and an L-shaped association in women. Adequate protein intake in healthy Japanese older adults was higher than the current recommended daily allowance.

    DOI PubMed

  • How many food items must be consumed to meet the recommended dietary protein intake for older Japanese adults?

    Daiki Watanabe, Tsukasa Yoshida, Aya Itoi, Hinako Nanri, Yosuke Yamada, Motohiko Miyachi, Misaka Kimura

    Geriatrics & gerontology international   22 ( 2 ) 181 - 183  2022.01  [Refereed]  [Domestic journal]

    Authorship:Lead author, Corresponding author

    DOI PubMed

  • Association between Water and Energy Requirements with Physical Activity and Fat-Free Mass in Preschool Children in Japan.

    Yosuke Yamada, Hiroyuki Sagayama, Jun Yasukata, Akiko Uchizawa, Aya Itoi, Tsukasa Yoshida, Daiki Watanabe, Yukako Hashii-Arishima, Hisashi Mitsuishi, Makoto Nishimura, Misaka Kimura, Yoshiko Aoki

    Nutrients   13 ( 11 )  2021.11  [Refereed]  [International journal]

     View Summary

    Water and energy are essential for the human body. The doubly labeled water (DLW) method measures water turnover (WT) and total energy expenditure (TEE), which serves as a benchmark for the adequate intake (AI) of water and estimated energy requirements (EER). The objective of the current study was to examine the association of WT and TEE with physical activity and body composition in Japanese preschool children. We included 41 preschool children (22 girls, 19 boys) aged 3-6 in this study. WT, TEE, and fat-free mass (FFM) were obtained using DLW. Physical activity was measured using a triaxial accelerometer and categorized as light (LPA; 1.5-2.9 Metabolic equivalents, METs) and of moderate-to-vigorous intensity (MVPA; ≥3.0 METs). Exercise duration (Ex) was defined as ≥4.0 METs of physical activity. WT and TEE moderately positively correlated with Ex, but not with LPA. WT moderately positively correlated with BW and FFM while TEE strongly. We established predictive equations for WT and TEE using body weight (BW), FFM, step count, and Ex to guide the AI of water and EER in Japanese preschool children. We found that FFM and step count are the determinants of TEE, and that BW and Ex are the determinants of WT in preschool children.

    DOI PubMed

  • Doubly labelled water-calibration approach attenuates the underestimation of energy intake calculated from self-reported dietary assessment data in Japanese older adults.

    Daiki Watanabe, Tsukasa Yoshida, Eiichi Yoshimura, Hinako Nanri, Chiho Goto, Kazuko Ishikawa-Takata, Naoyuki Ebine, Hiroyuki Fujita, Misaka Kimura, Yosuke Yamada

    Public health nutrition     1 - 11  2021.09  [Refereed]  [International journal]

    Authorship:Lead author, Corresponding author

     View Summary

    OBJECTIVE: Self-reported energy intake (EI) estimation may incur systematic errors that could be attenuated through biomarker calibration. We aimed to confirm whether calibrated EI was comparable to total energy expenditure (TEE) measured using the doubly labelled water (DLW) technique. DESIGN: Cross-sectional study. SETTING: General older population from the Kyoto-Kameoka Study, Japan. PARTICIPANTS: This study included sub- and main cohorts of 72 and 8058 participants aged≥ 65 years, respectively. EI was evaluated using a validated FFQ, and calibrated EI was obtained using a previously developed equation based on the DLW method. TEE was considered representative of true EI and also measured using the DLW method. We used a Wilcoxon signed-rank test and correlation analysis to compare the uncalibrated and calibrated EI with TEE. RESULTS: In the sub-cohort, the median TEE, uncalibrated EI and calibrated EI were 8559 kJ, 7088 kJ and 9269 kJ, respectively. The uncalibrated EI was significantly lower than the TEE (median difference = -1847 kJ; interquartile range (IQR): -2785 to -1096), although the calibrated EI was not (median difference = 463 kJ; IQR: -330 to 1541). The uncalibrated (r = 0·275) and calibrated EI (r = 0·517) significantly correlated with TEE. The reproducibility was higher for calibrated EI (interclass correlation coefficient (ICC) = 0·982) than for uncalibrated EI (ICC = 0·637). Similar findings were observed when stratifying the sample by sex. For medians, uncalibrated EI was lower (about 17 %) than calibrated EI in the main cohort. CONCLUSIONS: Biomarker calibration may improve the accuracy of self-reported dietary intake estimation.

    DOI PubMed

  • Adherence to the food-based Japanese dietary guidelines and prevalence of poor oral health-related quality of life among older Japanese adults in the Kyoto-Kameoka study.

    Daiki Watanabe, Kayo Kurotani, Tsukasa Yoshida, Hinako Nanri, Yuya Watanabe, Heiwa Date, Aya Itoi, Chiho Goto, Kazuko Ishikawa-Takata, Takeshi Kikutani, Mitsuyoshi Yoshida, Hiroyuki Fujita, Yosuke Yamada, Misaka Kimura

    The British journal of nutrition     1 - 10  2021.08  [Refereed]  [International journal]

    Authorship:Lead author, Corresponding author

     View Summary

    Although better diet quality is inversely related to the risk of geriatric disorders, the association of adherence to dietary guidelines with oral health-related quality of life (OHRQoL) is unclear. We aimed to investigate this association in older Japanese adults. This cross-sectional study included 7984 Japanese participants aged ≥ 65 years from the population-based Kyoto-Kameoka study. Dietary intake was estimated using a validated self-administered FFQ. The scores for adherence to the Japanese Food Guide Spinning Top (range: 0 (worst) to 80 (best)) were calculated. These scores were stratified into quartiles (Qs). Poor OHRQoL was defined as a score ≤ 50 using a 12-item Geriatric Oral Health Assessment Index. The OR and 95 % CI were calculated using multivariable logistic regression and the spline model. Higher adherence score was associated with a lower prevalence of poor OHRQoL (Q1-Q4:36·0 %, 32·1 %, 27·9 % and 25·1 %, respectively). An inverse association was found between the score for adherence to the food-based Japanese dietary guidelines and the OR of poor OHRQoL among all the participants (Q1: reference; Q2: OR, 0·87 (95 % CI: 0·75, 1·00); Q3: OR, 0·77 (95 % CI: 0·66, 0·90); Q4: OR, 0·72 (95 % CI: 0·62, 0·85); Pfor trend < 0·001). These relationships were similar to the results in the spline model. Higher adherence to the food-based Japanese dietary guidelines is inversely associated with the prevalence of poor OHRQoL in older adults. Our results may provide useful insights to improve and maintain oral health.

    DOI PubMed

  • 大阪府摂津市および阪南市における働く世代からのフレイル該当割合ならびにその関連要因

    吉田 司, 渡邉 大輝, 中潟 崇, 山田 陽介, 黒谷 佳代, 澤田 奈緒美, 田中 健司, 岡林 恵, 島田 秀和, 瀧本 秀美, 西 信雄, 宮地 元彦, 阿部 圭一

    日本公衆衛生雑誌   68 ( 8 ) 525 - 537  2021.08

  • Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults

    Daiki Watanabe, Haruka Murakami, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Kikue Todoroki-Mori, Yuta Tsunematsu, Michio Sato, Yuji Ogata, Noriyuki Miyoshi, Naoto Kubota, Jun Kunisawa, Keiji Wakabayashi, Tetsuya Kubota, Kenji Watanabe, Motohiko Miyachi

    BMC Microbiology   21 ( 1 ) 196 - 196  2021.06  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    <title>Abstract</title><sec>
    <title>Background</title>
    Colibactin-producing <italic>Escherichia coli</italic> containing polyketide synthase (<italic>pks</italic>+<italic>E. coli</italic>) has been shown to be involved in colorectal cancer (CRC) development through gut microbiota analysis in animal models. Stool status has been associated with potentially adverse gut microbiome profiles from fecal analysis in adults. We examined the association between stool patterns and the prevalence of <italic>pks</italic>+<italic>E. coli</italic> isolated from microbiota in fecal samples of 224 healthy Japanese individuals.


    </sec><sec>
    <title>Results</title>
    Stool patterns were determined through factorial analysis using a previously validated questionnaire that included stool frequency, volume, color, shape, and odor. Factor scores were classified into tertiles. The prevalence of <italic>pks</italic>+<italic>E. coli</italic> was determined by using specific primers for <italic>pks</italic>+<italic>E. coli</italic> in fecal samples. Plasma and fecal fatty acids were measured via gas chromatography-mass spectrometry. The prevalence of <italic>pks</italic>+<italic>E. coli</italic> was 26.8%. Three stool patterns identified by factorial analysis accounted for 70.1% of all patterns seen (factor 1: lower frequency, darker color, and harder shape; factor 2: higher volume and softer shape; and factor 3: darker color and stronger odor). Multivariable-adjusted odds ratios (95% confidence intervals) of the prevalence of <italic>pks</italic>+<italic>E. coli</italic> for the highest versus the lowest third of the factor 1 score was 3.16 (1.38 to 7.24; <italic>P</italic> for trend = 0.006). This stool pattern exhibited a significant positive correlation with fecal isobutyrate, isovalerate, valerate, and hexanoate but showed a significant negative correlation with plasma eicosenoic acid and α-linoleic acid, as well as fecal propionate and succinate. No other stool patterns were significant.


    </sec><sec>
    <title>Conclusions</title>
    These results suggest that stool patterns may be useful in the evaluation of the presence of tumorigenic bacteria and fecal fatty acids through self-monitoring of stool status without the requirement for specialist technology or skill. Furthermore, it may provide valuable insight about effective strategies for the early discovery of CRC.


    </sec>

    DOI PubMed

  • スポーツ科学における文献データサイエンス-系統的レビューとメタ解析について-

    Daiki Watanabe, Motohiko Miyachi

      71 ( 6 ) 392 - 397  2021.06  [Invited]

    Authorship:Lead author, Corresponding author

  • [Prevalence of frailty and its related factors in community-dwelling middle-aged and elderly adults in Settsu and Hannan cities in Osaka prefecture].

    Tsukasa Yoshida, Daiki Watanabe, Takashi Nakagata, Yosuke Yamada, Kayo Kurotani, Naomi Sawada, Kenji Tanaka, Megumi Okabayashi, Hidekazu Shimada, Hidemi Takimoto, Nobuo Nishi, Motohiko Miyachi, Keiichi Abe

    [Nihon koshu eisei zasshi] Japanese journal of public health   68 ( 8 ) 525 - 537  2021.05  [Refereed]  [Domestic journal]

     View Summary

    Objectives The purpose of this study was to examine the prevalence of frailty and its associated factors in community-dwelling middle-aged and elderly adults in Settsu and Hannan cities, which are located in the north and south of Osaka prefecture, respectively.Methods We conducted a mailed, self-administered, questionnaire survey of individuals aged 40 years and older in Settsu city in 2019 and Hannan city in 2020. There are 10 primary school districts in Settsu city and 8 districts in Hannan city, from each of which 1,000 people were selected according to the age and sex structures of the districts. We included 5,134 individuals from Settsu city and 3,939 individuals from Hannan city. We defined frailty using self-reported questionnaires, the Kihon Checklist (KCL), and Simple Frailty Index (SFI). Multivariate logistic regression analysis was performed for each city to examine the association of frailty with age, sex, body mass index (BMI), family structure, subjective health, economic status, subjective physical fitness, sleeping status, smoking history, alcohol use, meal frequency and awareness of the word "frailty."Results The average age (standard deviation) of participants was 62.7 (12.5) years in Settsu city and 63.4 (12.2) years in Hannan city. The prevalence of frailty by KCL was 18.7% and 17.9% for participants in their 40s, 18.2% and 14.6% for those in their 50s, 17.0% and 15.7% for those in their 60s, 25.4% and 20.8% for those in their 70s, 39.7% and 36.1% for those 80 years and older from Settsu and Hannan cities, respectively. Using SFI, the prevalence of frailty was 16.2% and 13.5% for participants in their 40s, 15.0% and 11.9% for those in their 50s, 12.5% and 10.0% for those in their 60s, 14.6% and 12.3% for those in their 70s, and 24.7% and 22.3% for those aged 80 years and older in Settsu and Hannan cities, respectively. Significant common independent variables associated with frailty as defined using the KCL and SFI in Settsu and Hannan cities were age, subjective health, economic status, subjective physical fitness, sleeping status, and awareness of the word "frailty."Conclusion This study found some participants to be frail as early as their 40s or 50s. Thus, efforts must be made to prevent frailty in working-age populations, including those aged 40 years and older. Six factors were associated with frailty. Longitudinal or interventional studies are required to examine their causal relationships and public health significance.

    DOI PubMed

  • Factors associated with sarcopenia screened by finger-circle test among middle-aged and older adults: a population-based multisite cross-sectional survey in Japan.

    Daiki Watanabe, Tsukasa Yoshida, Takashi Nakagata, Naomi Sawada, Yosuke Yamada, Kayo Kurotani, Kenji Tanaka, Megumi Okabayashi, Hidekazu Shimada, Hidemi Takimoto, Nobuo Nishi, Keiichi Abe, Motohiko Miyachi

    BMC public health   21 ( 1 ) 798 - 798  2021.04  [Refereed]  [International journal]

    Authorship:Lead author, Corresponding author

     View Summary

    BACKGROUND: Previous epidemiological studies have demonstrated the prevalence and relationship of various factors associated with sarcopenia in older adults; however, few have examined the status of sarcopenia in middle-aged adults. In this study, we aimed to, 1) evaluate the validity of the finger-circle test, which is potentially a useful screening tool for sarcopenia, and 2) determine the prevalence and factors associated with sarcopenia in middle-aged and older adults. METHODS: We conducted face-to-face surveys of 525 adults, who were aged 40-91 years and resided in Settsu City, Osaka Prefecture, Japan to evaluate the validity of finger-circle test. The finger-circle test evaluated calf circumference by referring to an illustration printed on the survey form. The area under the receiver operating characteristic curves (AUROC) was plotted to evaluate the validity of the finger-circle test for screening sarcopenia and compared to that evaluated by skeletal muscle mass index (SMI) measured using bioimpedance. We also conducted multisite population-based cross-sectional anonymous mail surveys of 9337 adults, who were aged 40-97 years and resided in Settsu and Hannan Cities, Osaka Prefecture, Japan. Participants were selected through stratified random sampling by sex and age in the elementary school zones of their respective cities. We performed multiple logistic regression analysis to explore associations between characteristics and prevalence of sarcopenia. RESULTS: Sarcopenia, defined by SMI, was moderately predicted by a finger-circle test response showing that the subject's calf was smaller than their finger-circle (AUROC: 0.729, < 65 years; 0.653, ≥65 years); such subjects were considered to have sarcopenia. In mail surveys, prevalence of sarcopenia screened by finger-circle test was higher in older subjects (approximately 16%) than in middle-aged subjects (approximately 8-9%). In a multiple regression model, the factors associated with sarcopenia were age, body mass index, smoking status, self-reported health, and number of meals in all the participants. CONCLUSIONS: Sarcopenia, screened by the finger-circle test, was present not only among older adults but also among middle-aged adults. These results may provide useful indications for developing public health programs, not only for the prevention, but especially for the management of sarcopenia. TRIAL REGISTRATION: UMIN000036880, registered prospectively May 29, 2019,  https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000042027.

    DOI PubMed

  • サクセスフル・エイジングに向けた健康政策とそのエビデンス 身体活動と栄養の科学からフレイルを考える

    宮地 元彦, 渡邉 大輝, 吉田 司, 山田 陽介

    健康支援   23 ( 1 ) 62 - 62  2021.02

  • Dose-Response Relationship Between Protein Intake and Muscle Mass Increase : Whole Concept of Sustainable Protein Intake

    Daiki Watanabe, Miyachi Motohiko

    Food processing and ingredients   56 ( 2 ) 8 - 11  2021.02  [Invited]

    Authorship:Lead author

  • Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials.

    Ryoichi Tagawa, Daiki Watanabe, Kyoko Ito, Keisuke Ueda, Kyosuke Nakayama, Chiaki Sanbongi, Motohiko Miyachi

    Nutrition reviews    2020.11  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    CONTEXT: Lean body mass is essential for health, yet consensus regarding the effectiveness of protein interventions in increasing lean body mass is lacking. OBJECTIVE: The aim of this systematic review was to evaluate the dose-response relationship of the effects of protein intake on lean body mass. DATA SOURCES: The PubMed and Ichushi-Web databases were searched electronically, and reference lists of the literature included here and in other meta-analyses were searched manually. STUDY SELECTION: Randomized controlled trials evaluating the effects of protein intake on lean body mass were included. DATA EXTRACTION: Two authors independently screened the abstracts; 5 reviewed the full texts. RESULTS: A total of 5402 study participants from 105 articles were included. In the multivariate spline model, the mean increase in lean body mass associated with an increase in protein intake of 0.1 g/kg of body weight per day was 0.39 kg (95%CI, 0.36-0.41) and 0.12 kg (95%CI, 0.11-0.14) below and above the total protein intake of 1.3 g/kg/d, respectively. CONCLUSIONS: These findings suggest that slightly increasing current protein intake for several months by 0.1 g/kg/d in a dose-dependent manner over a range of doses from 0.5 to 3.5 g/kg/d may increase or maintain lean body mass. SYSTEMATIC REVIEW REGISTRATION: UMIN registration number UMIN000039285.

    DOI PubMed

  • Objectively Measured Daily Step Counts and Prevalence of Frailty in 3,616 Older Adults.

    Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Misaka Kimura, Kyoto-Kameoka Study Group

    Journal of the American Geriatrics Society   68 ( 10 ) 2310 - 2318  2020.10  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    OBJECTIVES: Although previous studies have reported lower mortality and morbidity in people with higher daily step counts, the association between frailty and objectively measured step counts has not been evaluated well. We investigated the association between step counts and prevalence of frailty in community-dwelling older adults. DESIGN: A cross-sectional study. SETTING: The Kyoto-Kameoka study in Japan. PARTICIPANTS: We used data of 3,616 Japanese older adults, aged 65 years or older, with valid daily step count data, obtained by an accelerometer-based pedometer. MEASUREMENTS: The step count during 4 or more days was objectively obtained by a validated triaxial accelerometer. Participants were classified by quartiles (Qs) based on their step counts. Frailty was defined using the Fried phenotype (FP) model and the Kihon Checklist (KCL). We evaluated the association between prevalence of frailty and step counts using multivariate logistic regression and the restricted cubic spline model. RESULTS: Mean step counts across low-to-high Qs of distribution were 1,759, 2,988, 4,377, and 7,200 steps/day, respectively. The prevalence of frailty, as defined by the FP model and KCL, was 11.3% and 26.8%, respectively. After adjusting for confounders, there was a negative association between the odds ratio (OR) and prevalence of frailty, as defined by the FP model among people with higher step counts (Q1: reference; Q2: OR = 0.73; 95% confidence interval (CI) = 0.56-0.96; Q3: OR = 0.56; 95% CI = 0.42-0.76; and Q4: OR = 0.41; 95% CI = 0.30-0.57; P for trend <.001). The mean step count of the population was 4,081. The OR of frailty for a 1,000-steps/day increment was 0.74 (95% CI = 0.58-0.91) and 0.85 (95% CI = 0.72-0.97) below 4,000 steps and above 4,000 steps, respectively. In the spline model, this relationship was similar between the FP model and KCL. CONCLUSION: These findings suggest that slightly increasing the current step count, as by 1,000 steps/day (about 10 minutes of activity), may potentially prevent frailty. J Am Geriatr Soc 68:2310-2318, 2020.

    DOI PubMed

  • Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults.

    Daiki Watanabe, Haruka Murakami, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Yuta Tsunematsu, Michio Sato, Noriyuki Miyoshi, Keiji Wakabayashi, Kenji Watanabe, Motohiko Miyachi

    Scientific reports   10 ( 1 ) 15221 - 15221  2020.09  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    The relative contribution of diet to colorectal cancer (CRC) incidence is higher than that for other cancers. Animal models have revealed that Escherichia coli containing polyketide synthase (pks+ E. coli) in the gut participates in CRC development. The purpose of this cross-sectional study was to examine the relationship between dietary intake and the prevalence of pks+ E. coli isolated from the microbiota in faecal samples of 223 healthy Japanese individuals. Dietary intake was assessed using a previously validated brief-type self-administered diet history questionnaire. The prevalence of pks+ E. coli was evaluated using faecal samples collected from participants and specific primers that detected pks+ E. coli. The prevalence of pks+ E. coli was 26.9%. After adjusting for baseline confounders, the prevalence of pks+ E. coli was negatively associated with the intake of green tea (odds ratio [OR], 0.59 [95% confidence interval (CI) 0.30-0.88] per 100 g/1,000 kcal increment) and manganese (OR, 0.43 [95% CI 0.22-0.85] per 1 mg/1,000 kcal increment) and was positively associated with male sex (OR, 2.27 [95% CI 1.05-4.91]). While futher studies are needed to validate these findings, these results provide insight into potential dietary interventions for the prevention of CRC.

    DOI PubMed

  • Association between Mixing Ability of Masticatory Functions Measured Using Color-Changing Chewing Gum and Frailty among Japanese Older Adults: The Kyoto-Kameoka Study.

    Daiki Watanabe, Tsukasa Yoshida, Keiichi Yokoyama, Yasuko Yoshinaka, Yuya Watanabe, Takeshi Kikutani, Mitsuyoshi Yoshida, Yosuke Yamada, Misaka Kimura, Kyoto-Kameoka Study Group

    International journal of environmental research and public health   17 ( 12 )  2020.06  [Refereed]  [International journal]

    Authorship:Lead author, Corresponding author

     View Summary

    The relationship between mixing ability of masticatory functions and frailty has not been well evaluated. This study investigated the prevalence of physical and comprehensive frailty and its association with mixing ability in 1106 older adults aged ≥65 years who underwent physical examination as part of the Japanese Kyoto-Kameoka Study. Mixing ability was assessed using color-changing chewing gum (1-5 points, 5 representing the best mixing ability). Participants were divided into four groups (5 points, 4 points, 3 points, and 1 or 2 points). The modified Japanese versions of the Cardiovascular Health Study (mJ-CHS) criteria and the validated Kihon Checklist (KCL) were used to assess physical and comprehensive frailty, respectively. Multivariate logistic regression was used to evaluate the association between frailty and mixing ability. The prevalence of physical and comprehensive frailty was 11.8% and 27.9%, respectively. After adjusting for confounders, the odds ratios of physical and comprehensive frailty comparing the highest to the lowest chewing gum score groups were 3.64 (95% confidence interval (CI): 1.62 to 8.18; p for trend = 0.001) and 2.09 (95% CI: 1.09 to 4.03; p for trend = 0.009), respectively. Mixing-ability tests involving chewing gum may be an indicator associated with both physical and comprehensive frailty.

    DOI PubMed

  • Association between the prevalence of frailty and doubly labeled water-calibrated energy intake among community-dwelling older adults.

    Daiki Watanabe, Tsukasa Yoshida, Hinako Nanri, Yuya Watanabe, Heiwa Date, Aya Itoi, Chiho Goto, Kazuko Ishikawa-Takata, Hiroyuki Sagayama, Naoyuki Ebine, Hisamine Kobayashi, Misaka Kimura, Yosuke Yamada

    The journals of gerontology. Series A, Biological sciences and medical sciences   76 ( 5 ) 876 - 884  2020.06  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    BACKGROUND: Appropriate energy intake (EI) is essential to prevent frailty. Because self-reported EI is inaccurate and has systematic errors, adequate biomarker calibration is required. This study examined the association between doubly labeled water (DLW)-calibrated EI and the prevalence of frailty among community-dwelling older adults. METHODS: A cross-sectional study was performed using baseline data of 7022 older adults aged ≥65 years in the Kyoto-Kameoka Study. EI was evaluated using a validated food frequency questionnaire (FFQ), and calibrated EI was obtained from a previously established equation using the DLW method. Physical and comprehensive frailty were defined by the Fried phenotype (FP) model and the Kihon Checklist (KCL), respectively. We used multivariable-adjusted restricted cubic spline logistic regression analysis. RESULTS: The prevalence of physical frailty was 14.8% and 13.6% in women and men, respectively. The spline models showed significant reverse J-shaped or U-shaped relationships between the prevalence of physical or comprehensive frailty against the DLW-calibrated EI, respectively. The lowest prevalence of both types of frailty was found at 1900-2000 kcal·d-1 in women and 2400-2500 kcal·d-1 in men, which corresponded to approximately 40 kcal·d-1·kg IBW-1 (ideal body weight = 22 × height2) with DLW-calibrated EI. Uncalibrated EI underestimated approximately 20% compared with calibrated EI; underestimated EI were attenuated by calibration approach. CONCLUSIONS: This study suggests that low EI has a greater detrimental effect compared with excessive EI, particularly on physical frailty. Using biomarkers to calibrate EI holds promise for providing accurate energy requirements to establish guidelines used in public health and clinical nutrition.

    DOI PubMed

  • A U-Shaped Relationship Between the Prevalence of Frailty and Body Mass Index in Community-Dwelling Japanese Older Adults: The Kyoto-Kameoka Study.

    Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Misaka Kimura, Kyoto-Kameoka Study Group

    Journal of clinical medicine   9 ( 5 )  2020.05  [Refereed]  [International journal]

    Authorship:Lead author, Corresponding author

     View Summary

    The relationship between body mass index (BMI) and frailty remains unclear. Using two validated frailty assessment tools, this study aimed to investigate the relationship between the prevalence of frailty and BMI in Japanese older adults. This cross-sectional study used baseline data of 7191 individuals aged ≥65 years, living in Kameoka City, Kyoto, Japan. The BMI was calculated based on self-reported height and body weight, and classified into six categories. Frailty was defined using two validated assessment tools, the Fried phenotype (FP) model and Kihon Checklist (KCL). We evaluated the relationship between frailty and BMI using a multivariate restricted cubic spline logistic regression. The prevalence of frailty defined using the FP model was 25.3%, 19.6%, 14.3%, 12.4%, 12.6%, and 19.4% for each BMI category of <18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, and ≥27.5 kg/m2, respectively. The spline model showed a significant U-shaped relationship between BMI and the prevalence of frailty defined using both, KCL and FP models. This study found that the BMI range corresponding to lowest prevalence of frailty defined using both tools was 21.4-25.7 kg/m2. Thus, a healthy BMI may reduce the prevalence of frailty, and the risk of frailty needs to be evaluated in individuals who are underweight or overweight.

    DOI PubMed

  • 【予防から緩和ケアまでをサポートする 心臓病の栄養管理 食事療法】(III章)心臓病の最終共通像 心不全の栄養 慢性心不全における低栄養とその介入について[症例提示]

    木田 圭亮, 渡邉 大輝, 鈴木 規雄

    臨床栄養   別冊 ( 心臓病の栄養管理・食事療法 ) 106 - 111  2019.08  [Invited]

  • Estimation of Energy Intake by a Food Frequency Questionnaire: Calibration and Validation with the Doubly Labeled Water Method in Japanese Older People.

    Daiki Watanabe, Hinako Nanri, Hiroyuki Sagayama, Tsukasa Yoshida, Aya Itoi, Miwa Yamaguchi, Keiichi Yokoyama, Yuya Watanabe, Chiho Goto, Naoyuki Ebine, Yasuki Higaki, Kazuko Ishikawa-Takata, Misaka Kimura, Yosuke Yamada

    Nutrients   11 ( 7 )  2019.07  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    Accurate assessments of a target population's energy intake (EI) are essential to prevent poor nutritional status. However, self-reported dietary records (DRs) or food frequency questionnaires (FFQs) are not always accurate, thereby requiring validation and calibration studies. This study aimed to validate the EI estimated by a FFQ using the doubly labeled water (DLW) method. Participants were 109 Japanese older adults (50 women and 59 men) aged 65-88 years. The EI was obtained by a DR and 47-item FFQ over 1 year. The total energy expenditure (TEE) was measured by DLW for ~2 weeks. EI was significantly lower than TEE (p < 0.01); ratios of EI assessed by DR and FFQ against TEE were 0.91 ± 0.17 and 0.82 ± 0.22, respectively. TEE was significantly and moderately correlated with the EI estimated by the DR (r = 0.45, p < 0.01) and FFQ (r = 0.37, p < 0.01). Furthermore, the EI correlation coefficients estimated by DR and the FFQ in this study were not significantly different (p = 0.46). The EI/TEE ratio was significantly and negatively correlated with the body mass index (BMI). In conclusion, EI estimated with a DR or FFQ modestly correlated with TEE, and calibrating EI with a developed equation in this study can attenuate the underestimation of EI.

    DOI PubMed

  • Validation of Energy and Nutrition Intake in Japanese Elderly Individuals Estimated Based on a Short Food Frequency Questionnaire Compared against a 7-day Dietary Record: The Kyoto-Kameoka Study.

    Daiki Watanabe, Hinako Nanri, Tsukasa Yoshida, Miwa Yamaguchi, Mayu Sugita, Yoshizu Nozawa, Yuki Okabe, Aya Itoi, Chiho Goto, Yosuke Yamada, Kazuko Ishikawa-Takata, Hisamine Kobayashi, Misaka Kimura, Kyoto-Kameoka Study Kyoto-Kameoka Study Group

    Nutrients   11 ( 3 )  2019.03  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    To determine the association between geriatric disorders and dietary intake, validation of a food frequency questionnaire (FFQ) for elderly individuals is needed. We compared energy and nutrient intakes derived from dietary records (DR) and FFQ in an elderly population and compared the data against results from middle-aged individuals (30⁻68 years) from a previous study. Current participants included 65 women and 78 men (65⁻88 years) who completed FFQ and 7-day DR in a subpopulation of the Kyoto-Kameoka study. Our FFQ was created for middle-aged individuals. To validate the FFQ, we investigated equivalent precision by comparing the correlation coefficients between the present and previous study. Median correlations for energy and nutrient intake between the DR and FFQ in the current and previous studies were 0.24 and 0.30 (p = 0.329) in women and 0.24 and 0.28 (p = 0.399) in men, respectively. The median ratio of FFQ to DR for these intakes were also similar. The accuracy and precision of the FFQ for energy and nutrient intake in elderly individuals did not differ compared with previous findings in a middle-aged population. A validation study evaluating energy and nutrient intake using recovery biomarkers is further needed.

    DOI PubMed

  • Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway.

    Masaki Hara, Yuko Takeba, Taroh Iiri, Yuki Ohta, Masanori Ootaki, Minoru Watanabe, Daiki Watanabe, Satoshi Koizumi, Takehito Otsubo, Naoki Matsumoto

    Cancer science   110 ( 1 ) 235 - 244  2019.01  [Refereed]  [International journal]

     View Summary

    Vasoactive intestinal peptide (VIP) is a modulator of inflammatory responses. VIP receptors are expressed in several tumor types, such as colorectal carcinoma. The study described herein was conducted to confirm the presence of VIP and its receptors (VPAC1 and VPAC2) in surgically resected hepatocellular carcinoma (HCC) tissues and in the HCC cell line Huh7. The mechanism responsible for apoptosis of HCC cells was then examined because VIP treatment (10-10  M) significantly suppressed proliferation of Huh7 cells. In examining apoptosis-related proteins, we found caspase-3 to be significantly increased and Bcl-xL and cyclic AMP (cAMP) response element-binding protein (CREB) to be significantly decreased in Huh7 cells cultured with VIP. Furthermore, the CREB level and phosphorylation were reduced. These effects were reversed by the addition of VIP receptor antagonist or cAMP antagonist Rp-cAMPS. Pretreatment with cAMP analogue blocked the increased apoptosis, suggesting that VIP induces apoptosis via a PKA-independent signaling mechanism. Our data indicate that VIP prevents the progression of HCC by apoptosis through the cAMP/Bcl-xL pathway.

    DOI PubMed

  • Daily Yogurt Consumption Improves Glucose Metabolism and Insulin Sensitivity in Young Nondiabetic Japanese Subjects with Type-2 Diabetes Risk Alleles.

    Daiki Watanabe, Sachi Kuranuki, Akiko Sunto, Naoki Matsumoto, Teiji Nakamura

    Nutrients   10 ( 12 )  2018.11  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    This study investigated whether the association between postprandial plasma glucose (PPG) is affected by five type 2 diabetes mellitus (T2DM) susceptibility genes, and whether four weeks of yogurt consumption would affect these responses. We performed a single-arm intervention study in young nondiabetic Japanese participants, who consumed 150 g yogurt daily for four weeks, after which a rice test meal containing 50 g carbohydrate was administered. PPG and postprandial serum insulin (PSI) were measured between 0 and 120 mins at baseline and after the intervention. Genetic risk was evaluated by weighted genetic risk score (GRS) according to published methodology, and participants were assigned to one of two groups (n = 17: L-GRS group and n = 15: H-GRS group) according to the median of weighted GRS. At baseline, the H-GRS group had higher glucose area under the curve0⁻120 min after intake of the test meal than the L-GRS group (2175 ± 248 mg/dL.min vs. 1348 ± 199 mg/dL.min, p < 0.001), but there were no significant differences after the yogurt intervention. However, there was an improvement in PSI in the H-GRS group compared with baseline. These results suggest that habitual yogurt consumption may improve glucose and insulin responses in nondiabetic subjects who have genetically higher PPG.

    DOI PubMed

  • Age Modifies the Association of Dietary Protein Intake with All-Cause Mortality in Patients with Chronic Kidney Disease.

    Daiki Watanabe, Shinji Machida, Naoki Matsumoto, Yugo Shibagaki, Tsutomu Sakurada

    Nutrients   10 ( 11 )  2018.11  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    Whether the effect of a low-protein diet on progression to end-stage renal disease (ESRD) and mortality risk differs between young and elderly adults with chronic kidney disease (CKD) is unclear. We conducted a retrospective CKD cohort study to investigate the association between protein intake and mortality or renal outcomes and whether age affects this association. The cohort comprised 352 patients with stage G3-5 CKD who had been followed up for a median 4.2 years, had undergone educational hospitalization, and for whom baseline protein intake was estimated from 24-h urine samples. We classified the patients into a very low protein intake (VLPI) group (<0.6 g/kg ideal body weight/day), a low protein intake (LPI) group (0.6⁻0.8 g), and a moderate protein intake (MPI) group (>0.8 g). Compared with the LPI group, the MPI group had a significantly lower risk of all-cause mortality (hazard ratio: 0.29; 95% confidence interval: 0.07 to 0.94) but a similar risk of ESRD, although relatively high protein intake was related to a faster decline in the estimated glomerular filtration rate. When examined per age group, these results were observed only among the elderly patients, suggesting that the association between baseline dietary protein intake and all-cause mortality in patients with CKD is age-dependent.

    DOI PubMed

  • 出生前グルココルチコイド投与によるラットの胎仔肝臓におけるビリルビン代謝関連トランスポーター multidrug resistance-associated protein(MRP)2の発現

    武半 優子, 桜井 研三, 長田 洋資, 水野 将徳, 都築 慶光, 太田 有紀, 大滝 正訓, 渡辺 実, 町田 貴史, 渡邉 大輝, 中村 悠城, 小林 司, 飯利 太朗, 松本 直樹

    聖マリアンナ医科大学雑誌   45 ( 4 ) 281 - 287  2018.03  [Refereed]

     View Summary

    早産児の肝臓はビリルビンの代謝能が十分でないため黄疸が出現しやすく、重症化することもある。臨床において早産での出生が予想される場合、妊娠母体にグルココルチコイド(GC)投与を施行する。我々は、出生前GC投与が早産児の心臓や肺の発達に寄与することを明らかにしたが、肝臓への作用はまだ不明である。本研究では出生前GC投与によるラット胎仔の肝臓機能への作用について、ビリルビンの代謝に関与する因子に着目し検討した。妊娠ラットの17日および18日目に、デキサメタゾン(DEX)を2日間連続で皮下投与し、19日目に帝王切開で出産させた早産胎仔の肝臓を実験に供した。また自然分娩で出生させた日齢1日目の肝臓を比較対象とした。肝臓組織のアルブミン、ビリルビン代謝に関与するトランスポーターであるmultidrug resistance-associated protein(MRP)2およびorganic anion-transporting plypeptide(OATP)1の蛋白発現を免疫組織染色で検討した。19日胎仔の肝臓組織像は、日齢1ラットと比較し肝実質細胞の構築が未熟で細胞の大きさも不均一であった。しかしDEX投与した肝臓組織では、非投与群と比較しアルブミン、MRP2の発現が増強した。OATP1の発現に影響がなかった。DEXは胎仔肝臓の発達を促進し、ビリルビンの排泄能を増強させることが示唆された。(著者抄録)

  • Molecular dynamics studies of the pH-dependent dynamic structure on CYP2D6

    Masanori Ootaki, Yuki Ohta, Yuko Takeba, Minoru Watanabe, Tsukasa Kobayashi, Yuki Nakamura, Daiki Watanabe, Makoto Yamamoto, Taroh Iiri, Naoki Matsumoto

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   WCP2018 ( 0 ) PO1 - 13  2018

    DOI

  • Introduction of a cartilage calcification insufficient rat as an infertile model animal

    Minoru Watanabe, Masami Tanaka, Yuko Takeba, Masanori Ootaki, Yuki Ohta, Taroh Iiri, Tsukasa Kobayashi, Daiki Watanabe, Toshio Kumai, Naoki Matsumoto

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   WCP2018 ( 0 ) PO4 - 10  2018

    DOI

  • 日本人の小腸におけるシトクロムP450アイソザイムの集団プロフィール(Population Profile of Cytochrome P450 Isozymes i the Small Intestine of Japanese)

    Takenoshita-Nakaya Sachiko, Takeba Yuko, Ohta Yuki, Ootaki Masanori, Watanabe Minoru, Iiri Taroh, Otsubo Takehito, Kobayashi Tsukasa, Machida Takafumi, Watanabe Daiki, Nakamura Yuki, Yamamoto Makoto, Kumai Toshio, Kobayashi Shinichi, Matsumoto Naoki

    臨床薬理   49 ( 1 ) 3 - 6  2018.01  [Refereed]

     View Summary

    シトクロムP450(CYP)は小腸にも存在して、経口投与された薬物の初回通過代謝の原因となるので、白人では小腸のCYPアイソザイムの分布が調べられているが、日本人では調べられていない。聖マリアンナ医大で膵頭十二指腸切除を受けた34名の患者の小腸組織について、CYP(1A2、2C9、2C19、2D6、3A4、3A5)のmRNA発現をリアルタイムRT-PCRで分析した。CYP3A4(63.2%)が主要なCYPで、続いてCYP2C19(21.3%)が多く発現していた。Paine等(2006)の報告によれば、白人ではCYP3A4(82%)が主で、続いてCYP2C9(14%)であり、日本人と白人では小腸でのCYP発現には差が認められた。日本人と白人では経口薬の初回通過代謝や併用薬の相互作用に差がある可能性が示された。

  • Abnormality of the proteoglycan expression in the ovary of the cartilage calcification insufficient (CCI) rat

    Minoru Watanabe, Masami Tanaka, Yuko Takeba, Masanori Ootaki, Yuki Ohta, Taroh Iiri, Daiki Watanabe, Toshio Kumai, Naoki Matsumoto

    JOURNAL OF PHARMACOLOGICAL SCIENCES   133 ( 3 ) S256 - S256  2017.03  [Refereed]

  • 新規KSP阻害薬のKPYB10602は乳癌細胞において有糸分裂停止と細胞死を誘導する(A Novel KSP Inhibitor, KPYB10602, Induces Mitotic Arrest and Cell Death in Breast Cancer Cells)

    Kojima-Tsuchiya Seiko, Ohta Yuki, Takenaga Mitsuko, Niimi Jun, Watanabe Daiki, Tsunoda Satoshi, Ootaki Masanori, Oishi Shinya, Fujii Nobutaka, Matsumoto Naoki, Tsugawa Koichiro

    Journal of St. Marianna University   7 ( 2 ) 105 - 116  2016.12  [Refereed]

     View Summary

    乳癌に対する新規Kinesin spindle protein(KSP)阻害薬KPYB10602の制癌作用を、乳癌細胞および乳癌細胞の皮下異種移植モデルマウスを用いて検討した。本剤の抗増殖活性、制癌作用、阻害機序をcell viability assay、免疫蛍光顕微鏡法、フローサイトメトリー、ELISA、ウエスタンブロット法により調査した。本剤は、MCF-7、MDA-MB-231、HCC1937細胞株において制癌作用を示した。本剤を処置することで有糸分裂停止とmonopolar spindle formationが誘導された後、アポトーシス細胞死が誘導されることが示された。さらに本剤は、皮下異種移植モデルマウスの腫瘍増殖を効果的に抑制した。KPYB10602は乳癌の新規抗癌剤になりうると考えられた。

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Books and Other Publications

  • 食と医療 2017FALL-WINTER Vol.3

    町田慎治, 渡邉大輝, 柴垣有吾( Part: Contributor, CKD 領域におけるたんぱく質制限食のエビデンスの現状と今後の展望)

    「食と医療」事務局  2017.10 ISBN: 9784065095959

Misc

  • CYP2D6のpHに依存した分子動力学計算

    大滝 正訓, 太田 有紀, 渡辺 実, 小林 司, 中村 悠城, 渡邉 大輝, 山本 信, 武半 優子, 飯利 太朗, 松本 直樹

    日本薬学会年会要旨集   138年会 ( 2 ) 268 - 268  2018.03

  • ラットの出生前グルココルチコイド投与による胎仔肝臓におけるMultidrug resistance protein(MRP)2発現の検討

    武半 優子, 長田 洋資, 桜井 研三, 都築 慶光, 渡辺 実, 太田 有紀, 大滝 正訓, 渡邊 大輝, 飯利 太朗, 松本 直樹

    臨床薬理   47 ( Suppl. ) S228 - S228  2016.10

Awards

  • Editor’s Choice

    2020.10   Journal of Clinical Medicine   A U-Shaped Relationship between the Prevalence of Frailty and Body Mass Index in Community-Dwelling Japanese Older Adults: The Kyoto–Kameoka Study

  • Paper Award

    2020.03   St. Marianna University School of Medicine   Age modifies the association of dietary protein intake with all-cause mortality in patients with chronic kidney disease

  • Editor’s Choice (Feature Paper)

    2018.11   Nutrients   Daily yogurt consumption improves glucose metabolism and insulin sensitivity in young nondiabetic Japanese subjects with type-2 diabetes risk alleles

  • Young Investigator Award

    2015.10   Japanese Society of Clinical Nutrition  

Research Projects

  • フレイル概念モデルに着目した生物学的老化に関わるバイオマーカーの網羅的探索

    日本学術振興会  科学研究費助成事業 若手研究

    Project Year :

    2021.04
    -
    2023.03
     

    渡邉 大輝

  • Association between temporal changes in diet quality and concurrent changes in dietary intake, body mass index, and physical activity among Japanese adults: A longitudinal study

    Danone Institute of Japan Foundation  Danone Research Grant

    Project Year :

    2022.01
    -
    2022.12
     

    Daiki Watanabe, Motohiko Miyachi

  • 多様な食品摂取は四肢骨格筋量の維持・向上につながるか〜高齢者のサルコペニア予防の推進を目指したコホート研究〜

    株式会社 タニタ  2019年度 公益信託 タニタ健康体重基金

    Project Year :

    2019.11
    -
    2021.11
     

    中潟崇, 吉田司, 渡邉大輝, 山田陽介, 木村みさか

  • 高齢者が健康を維持するために必要な身体活動量と栄養摂取量の定量化 ~指導者が自信を持って指導できるためのエビデンスの提供~

    Project Year :

    2020.04
    -
    2021.03
     

    Tsukasa Yoshida, Nakagata Takashi, Daiki Watanabe, Hiroyuki Sagayama

  • ヨーグルトの長期投与が健常人の空腹時及び食後の血糖値に及ぼす影響

    公益財団法人ダノン健康栄養財団  ダノン学術研究助成金

    Project Year :

    2014.01
    -
    2014.12
     

    倉貫早智, 渡邉大輝, 駿藤晶子, 中村 丁次

Presentations

  • 中高齢者における指輪っかテストでスクリーニングされたサルコペニアに関連する要因

    渡邉大輝, 吉田司, 中潟崇, 澤田奈緒美, 山田陽介, 黒谷佳代, 岡林恵, 島田秀和, 瀧本秀美, 西信雄, 阿部圭一, 宮地元彦

    第80回日本公衆衛生学会総会 

    Presentation date: 2021.12

    Event date:
    2021.12
     
     
  • 指輪っかテストと基本チェックリストとの関連性:中高齢者を対象とした調査

    谷出敦子, 吉田司, 渡邉大輝, 中潟崇, 山田陽介, 澤田奈緒美, 岡林恵, 島田秀和, 西信雄, 宮地元彦

    第80回日本公衆衛生学会総会 

    Presentation date: 2021.12

    Event date:
    2021.12
     
     
  • BMI階層別にみたフレイルの該当割合:中年者と高齢者の比較

    疋田愛里香, 渡邉大輝, 吉田司, 中潟崇, 山田陽介, 澤田奈緒美, 岡林恵, 島田秀和, 西信雄, 宮地元彦

    第80回日本公衆衛生学会総会 

    Presentation date: 2021.12

    Event date:
    2021.12
     
     
  • 高齢者における校正済みたんぱく質摂取量と包括的フレイルとの関連:Kyoto-Kameoka Study

    南里妃名子, 渡邉大輝, 吉田司, 吉村英一, 岡辺有紀, 小野美保, 小泉友範, 小林久峰, 藤田裕之, 木村みさか, 山田陽介

    第8回日本サルコペニア・フレイル学会大会 

    Presentation date: 2021.11

    Event date:
    2021.11
     
     
  • 40歳以上の地域住民を対象としたフレイルチェックとフレイル保健指導の効果検証:対照群無し前後比較研究

    和田理紗子, 有島裕香子, 渡邉大輝, 吉田司, 中潟崇, 澤田奈緒美, 島田秀和, 西信雄, 宮地元彦

    第8回日本サルコペニア・フレイル学会大会 

    Presentation date: 2021.11

    Event date:
    2021.11
     
     
  • 地域在住高齢者における下肢骨格筋の量的、質的指標と咀嚼機能の関連

    渡邊 裕也, 渡邉 大輝, 吉田 司, 山田 陽介, 横山 慶一, 山縣恵美, 木村みさか

    第8回日本サルコペニア・フレイル学会大会 

    Presentation date: 2021.11

    Event date:
    2021.11
     
     
  • 総たんぱく質摂取量と筋量増加の間の量反応関係:系統的レビューと多変量調整スプラインモデ ル解析

    渡邉 大輝, 田川 亮一, 伊藤 恭子, 上田 啓輔, 中山 恭佑, 三本木 千秋, 宮地 元彦

    第68回日本栄養改善学会学術総会 

    Presentation date: 2021.10

    Event date:
    2021.10
     
     
  • たんぱく質摂取が筋量増加に及ぼす影響:ランダム化比較試験の系統的レビューとメタ解析

    田川 亮一, 渡邉 大輝, 伊藤 恭子, 上田 啓輔, 中山 恭佑, 三本木 千秋, 宮地 元彦

    第68回日本栄養改善学会学術総会 

    Presentation date: 2021.10

    Event date:
    2021.10
     
     
  • Prevalence of frailty and its related factors in community-dwelling middle-aged and older adults in Japan -reproducibility in two cities-

    Tsukasa Yoshida, Daiki Watanabe, Takashi Nakagata, Yosuke Yamada, Kayo Kurotani, Naomi Sawada, Megumi Okabayashi, Hidekazu Shimada, Hidemi Takimoto, Nobuo Nishi, Motohiko Miyachi, Keiichi Abe

    11th Annual International Conference on Frailty and Sarcopenia Research ICFSR 2021 

    Presentation date: 2021.09

    Event date:
    2021.09
    -
    2021.10
  • 地域在住高齢者におけるフレイル有症率と超音波を用いた下肢骨格筋の量的、質的指標との関連:Kyoto Kameoka Study

    渡邊裕也, 渡邉大輝, 吉田司, 山田陽介, 木村みさか

    第76回 日本体力医学会大会 

    Presentation date: 2021.09

    Event date:
    2021.09
     
     
  • 身体活動と栄養の科学からフレイルを考える

    宮地元彦, 渡邉大輝, 吉田司, 山田陽介  [Invited]

    第22回日本健康支援学会年次学術大会・第8回日本介護予防・健康づくり学会大会 

    Presentation date: 2021.03

  • 高齢者のサルコぺニアと食品摂取の多様性スコアの関係

    糸井亜弥, 山田陽介, 中潟崇, 吉田司, 渡邉大輝, 木村みさか

    第75回日本体力医学会大会 

    Presentation date: 2020.09

    Event date:
    2020.09
     
     
  • A U-Shaped Relationship Between the Prevalence of Frailty and Body Mass Index in Community- Dwelling Japanese Older Adults: The Kyoto–Kameoka Study

    Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Misaka Kimura

    Presentation date: 2020.09

    Event date:
    2020.09
     
     
  • 食物摂取頻度調査法によるエネルギー摂取量の推定:高齢者での二重標識水法による妥当性および較正式の検討

    渡邉大輝, 南里妃名子, 下山 寛之, 吉田司, 糸井亜弥, 山口美輪, 横山慶一, 渡邊裕也, 後藤千穂, 海老根直之, 檜垣靖樹, 高田和子, 木村みさか, 山田陽介

    第30回日本疫学会学術総会 

    Presentation date: 2020.02

    Event date:
    2020.02
     
     
  • molecular dynamics simulation of CYP2D6 and CYP2C19

    Ootaki Masanori, Matsumoto Naoki, Ohta Yuki, Watanabe Minoru, Kobayashi Tsukasa, Nakamura Yuki, Watanabe Daiki, Kida Keisuke, Takeba Yuko, Iiri Taroh

    Proceedings for Annual Meeting of The Japanese Pharmacological Society  Japanese Pharmacological Society

    Presentation date: 2020

    Event date:
    2020
     
     

     View Summary

    <p>CYP2D6 and CYP2C19 affects metabolization of some drugs, and examination of its mechanism of action is important for understanding drug metabolism. CYPs is expressed not only in the liver but also in the small intestine, and is known to affect the first pass effect. Enzymatic reactions are altered depending upon pH, temperature, and other internal conditions of the body, resulting different the liver or small intestine, though difficult to be evaluated. In the previous study, we have reported the possibility that CYP2D6 isolated from the human liver and small intestine may have different activities. In the present study, we used molecular dynamics calculations to investigate the effects of environmental conditions on the activity and stability of CYP2D6 and 2C19 such as pH around the protein. </p><p>AMBER16 was used for molecular dynamics simulation of CYP2D6 and 2C19, and the wild type protein registered in Protein Data Bank was used as the initial structure (PDB ID 3qm4, 4gqs). In CYP2D6, there are 13 His residues, and His376 is in the proximity of heme iron. When periodic boundary condition were used with these residues differing in the side chain dissociation state (pH6.5, 7.5) to evaluate structural changes in the active center. </p><p>When His was dissociated, changes in the crystal structure were observed for His416, His477, and His478 residues exposed on the surface of CYP2D6; the side chain moved by 1.8 Å.  On the other hand, when His376 in the vicinity of the active center was dissociated, the side chain of His376 itself was twisted, resulting in the maximum deviation of about 1 Å with about 60° distortion from the crystal structure. </p><p>However, virtually no changes from the crystal structure occurred with respect to the heme group. The concluded that structural differences between pH 6.5 and pH 7.5 have little effect on the CYP2D6 activity and stability.</p>

  • 地域高齢者における咀嚼能力と主観的な口腔健康度との関連

    和田 理紗子, 渡邉 大輝, 吉田 司, 横山 慶一, 吉中 康子, 渡邊 裕也, 吉田 光由, 山田 陽介, 木村 みさか

    日本病態栄養学会誌  (一社)日本病態栄養学会

    Presentation date: 2020.01

    Event date:
    2020.01
     
     
  • 肝細胞癌患者の非癌部位肝組織における癌幹細胞マーカーの発現と患者生存率との関係 ヒト組織バンク検体を用いた研究

    渡邉 大輝, 武半 優子, 太田 有紀, 大滝 正訓, 小林 司, 木田 圭亮, 渡辺 実, 原 雅樹, 大坪 毅人, 飯利 太朗, 松本 直樹

    臨床薬理  (一社)日本臨床薬理学会

    Presentation date: 2019.11

    Event date:
    2019.11
     
     
  • 大阪府摂津市の中高年におけるフレイルの実態 大阪府健康格差解決プログラム促進事業

    吉田 司, 西 信雄, 宮地 元彦, 渡邉 大輝, 黒谷 佳代, 瀧本 秀美, 山田 陽介, 島田 秀和, 澤田 奈緒美, 阿部 圭一

    日本公衆衛生学会総会抄録集  日本公衆衛生学会

    Presentation date: 2019.10

    Event date:
    2019.10
     
     
  • 若年女性を対象とした食事の質と食後血糖値の関連

    倉貫早智, 井上裕美子, 渡邉大輝

    第66回 日本栄養改善学会学術総会 

    Presentation date: 2019.09

    Event date:
    2019.09
     
     
  • 食事記録を基準とした食物摂取頻度調査の妥当性:高齢者および中高年を対象としたコホート間の比較

    渡邉大輝, 南里妃名子, 吉田司, 山口美輪, 杉田麻友, 野沢与志津, 岡辺有紀, 糸井亜弥, 後藤千穂, 山田陽介, 高田和子, 小林久峰, 木村みさか

    第66回 日本栄養改善学会学術総会 

    Presentation date: 2019.09

    Event date:
    2019.09
     
     
  • AKIとCKDの栄養管理 CKD患者を対象としたたんぱく質摂取量と総死亡リスクについて

    渡邉 大輝, 町田 慎治, 松本 直樹, 柴垣 有吾, 櫻田 勉  [Invited]

    学会誌JSPEN  (一社)日本静脈経腸栄養学会

    Presentation date: 2019.09

    Event date:
    2019.09
     
     
  • ヨーグルトの習慣的摂取が糖尿病感受性遺伝子SNPsを持つ健常若年者の糖代謝に及ぼす影響

    倉貫 早智, 渡邉 大輝, 駿藤 晶子, 中村 丁次

    日本栄養・食糧学会大会講演要旨集  (公社)日本栄養・食糧学会

    Presentation date: 2019.04

    Event date:
    2019.04
     
     
  • 妊娠ラットへのデキサメサゾン投与による胎仔心臓のAgrin発現量の検討

    中村悠城, 武半優子, 小林司, 山本信, 渡邉大輝, 大滝正訓, 太田有紀, 渡辺実, 木田圭亮, 飯利太朗, 松本直樹

    第25回日本胎児心臓病学会学術集会 

    Presentation date: 2019.02

    Event date:
    2019.02
     
     
  • CKD患者を対象としたたんぱく質摂取量と総死亡リスクについて

    渡邉大輝  [Invited]

    第23回包括的腎不全医療研究会 

    Presentation date: 2018.11

    Event date:
    2018.11
     
     
  • Introduction of a cartilage calcification insufficient rat as infertile model animal

    Minoru Watanabe, Masami Tanaka, Yuko Takeba, Masanori Ootaki, Yuki Ohta, Taroh Iiri, Tsukasa Kobayashi, Daiki Watanabe, Toshio Kumai, Naoki Matsumoto

    18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY 

    Presentation date: 2018.07

    Event date:
    2018.07
     
     
  • Molecular dynamics studies of the pH-dependent dynamic structure on CYP2D6

    Masanori Ootaki, Yuki Ohta, Minoru Watanabe, Tsukasa Kobayashi, Yuki Nakamura, Daiki Watanabe, Makoto Yamamoto, Yuko Takeba, Taroh Iiri, Naoki Matsumoto

    18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY 

    Presentation date: 2018.07

    Event date:
    2018.07
     
     
  • Production of Bilirubin Transporters, MRP 2 in the Feteral Rat Liver with Antenatal Glucocorticoid Administration

    武半優子, 桜井研三, 長田洋資, 都築慶光, 太田有紀, 大滝正訓, 渡辺実, 渡邉大輝, 中村悠城, 小林司, 飯利太朗, 松本直樹

    Presentation date: 2018.07

    Event date:
    2018.07
     
     
  • Efficacy of dapagliflozin on postprandial plasma glucose in adults with type 2 diabetes: a systematic review and meta-analysis of data from randomized placebo-controlled trials

    Daiki Watanabe, Masanori Ootaki, Yuki Ohta, Yuko Takeba, Noriko Makita, Taroh Iiri, Naoki Matsumoto

    18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY 

    Presentation date: 2018.07

    Event date:
    2018.07
     
     
  • ラット胎仔肝臓における胎生期グルココルチコイド投与によるビリルビン輸送体MRP2の産生(Production of Bilirubin Transporters, MRP 2 in the Fetal Rat Liver with Antenatal Glucocorticoid Administration)

    武半 優子, 桜井 研三, 長田 洋資, 都築 慶光, 太田 有紀, 大滝 正訓, 渡辺 実, 渡邉 大輝, 中村 悠城, 小林 司, 飯利 太朗, 松本 直樹

    臨床薬理  (一社)日本臨床薬理学会

    Presentation date: 2018.05

    Event date:
    2018.05
     
     
  • CKD教育入院患者を対象としたたんぱく質摂取量と総死亡リスクについて

    渡邉 大輝, 櫻田 勉, 松本 直樹, 柴垣 有吾

    日本腎臓学会誌  (一社)日本腎臓学会

    Presentation date: 2018.04

    Event date:
    2018.04
     
     
  • 新規KSP阻害のヒト乳癌細胞に対する効果

    太田 有紀, 土屋 聖子, 武永 美津子, 新美 純, 渡邉 大輝, 大滝 正訓, 大石 真也, 藤井 信孝, 津川 浩一郎, 松本 直樹

    日本薬学会年会要旨集  (公社)日本薬学会

    Presentation date: 2018.03

    Event date:
    2018.03
     
     
  • CYP2D6のpHに依存した分子動力学計算

    大滝 正訓, 太田 有紀, 渡辺 実, 小林 司, 中村 悠城, 渡邉 大輝, 山本 信, 武半 優子, 飯利 太朗, 松本 直樹

    日本薬学会年会要旨集  (公社)日本薬学会

    Presentation date: 2018.03

    Event date:
    2018.03
     
     
  • 肝細胞癌患者の肝臓組織におけるCD133とEpCAMのタンパク質発現

    渡邉 大輝, 武半 優子, 太田 有紀, 大滝 正訓, 渡辺 実, 原 雅樹, 飯利 太朗, 松本 直樹

    臨床薬理  (一社)日本臨床薬理学会

    Presentation date: 2017.11

    Event date:
    2017.11
     
     
  • CYP2D6のpHに着目した分子動力学計算

    大滝正訓, 武半優子, 太田有紀, 渡辺実, 中村悠城, 渡邉大輝, 小林司, 飯利太朗, 松本直樹

    第137回日本薬理学会関東部会 

    Presentation date: 2017.10

    Event date:
    2017.10
     
     
  • 新規合成KSP阻害薬KPYB10602の乳癌細胞に対する分裂期停止および細胞死の誘導

    土屋 聖子, 太田 有紀, 武永 美津子, 新美 純, 渡邉 大輝, 角田 智志, 大滝 正則, 大石 真也, 藤井 信孝, 松本 直樹, 津川 浩一郎

    聖マリアンナ医科大学雑誌  聖マリアンナ医科大学医学会

    Presentation date: 2017.08

    Event date:
    2017.08
     
     
  • ヒト小腸と肝臓におけるプロトンポンプ阻害薬ランソプラゾールを指標薬物としたCYP3A4活性の比較

    渡邉 大輝, 武半 優子, 渡辺 実, 太田 有紀, 大滝 正訓, 原 雅樹, 竹ノ下 祥子, 飯利 太朗, 松本 直樹

    聖マリアンナ医科大学雑誌  聖マリアンナ医科大学医学会

    Presentation date: 2017.05

    Event date:
    2017.05
     
     
  • 軟骨石灰化不全ラット(CCIラット)卵巣におけるプロテオグリカンの発現異常

    渡辺実, 田中政已, 武半優子, 大滝正訓, 太田有紀, 飯利太朗, 渡邉大輝, 熊井俊夫, 松本直樹

    第90回日本薬理学会年会 

    Presentation date: 2017.03

    Event date:
    2017.03
     
     
  • 自然発症不妊症ラットの不妊機序の解明

    渡辺 実, 田中 政巳, 武半 優子, 太田 有紀, 大滝 正訓, 飯利 太朗, 渡邉 大輝, 熊井 俊夫, 松本 直樹

    臨床薬理  (一社)日本臨床薬理学会

    Presentation date: 2016.10

    Event date:
    2016.10
     
     
  • ヒト小腸と肝臓におけるプロトンポンプ阻害薬ランソプラゾールを指標薬物としたCYP3A4活性の比較

    渡邉 大輝, 武半 優子, 渡辺 実, 太田 有紀, 大滝 正訓, 原 雅樹, 松本 直樹

    臨床薬理  (一社)日本臨床薬理学会

    Presentation date: 2016.10

    Event date:
    2016.10
     
     
  • 食事の組み合わせによる食後血糖値と糖尿病感受性遺伝子SNPsとの関連

    倉貫 早智, 渡邉 大輝, 小原 亜矢香, 瀬下 美沙, 駿藤 晶子, 中村 丁次

    New Diet Therapy  (一社)日本臨床栄養協会

    Presentation date: 2015.09

    Event date:
    2015.09
     
     
  • 5つの糖尿病感受性遺伝子の遺伝リスクスコアは食後血糖上昇と関連し、ヨーグルトの長期的摂取によって改善

    渡邉 大輝, 倉貫 早智, 駿藤 晶子, 中村 丁次

    New Diet Therapy  (一社)日本臨床栄養協会

    Presentation date: 2015.09

    Event date:
    2015.09
     
     
  • The long term intake of yogurt and postprandial blood glucose level are associated with diabetes related SNPs

    Daiki Watanabe, Sachi Kuranuki, Akiko Sunto, Naoki Matsumoto, Nakamura Teiji

    12th Asian Congress of Nutrition 

    Presentation date: 2015.05

    Event date:
    2015.05
     
     
  • 食品の組み合わせによる食後の血糖変動と糖尿病家族歴の関連

    渡邉 大輝, 前村 知恵, 北原 愛梨, 駿藤 晶子, 倉貫 早智, 中村 丁次

    New Diet Therapy  (一社)日本臨床栄養協会

    Presentation date: 2014.09

    Event date:
    2014.09
     
     
  • 食品の組み合わせや乳製品の習慣的摂取が若年者における食後血糖上昇抑制に及ぼす影響

    渡邉大輝, 倉貫早智, 駿藤晶子, 中村丁次

    第61回日本栄養改善学会学術総会 

    Presentation date: 2014.08

    Event date:
    2014.08
     
     
  • 糖尿病家族歴の有無による血糖変動について

    渡邉大輝, 清水瑠美子

    第9回日本栄養改善学会北陸支部会学術総会 

    Presentation date: 2014.02

    Event date:
    2014.02
     
     

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Syllabus

Teaching Experience

  • Biological function practice

    St.Marianna University School of Medicine  

    2016.04
    -
    2020.03
     

  • Pharmacology practice

    St.Marianna University School of Medicine  

    2016.04
    -
    2020.03
     

  • Public Health Nutrition

    Kanagawa University of Human Services  

    2015.04
    -
    2016.03
     

  • Graduation research

    Kanagawa University of Human Services  

    2015.04
    -
    2016.03
     

 

Committee Memberships

  • 2019.10
    -
    2021.03

    National Cancer Center  Nutrition Guidelines for Cancer Survivors

Media Coverage

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