Updated on 2024/04/17

写真a

 
NAKAMURA, Nobuhiro
 
Affiliation
Faculty of Sport Sciences, School of Sport and Sciences
Job title
Assistant Professor(non-tenure-track)
Degree
博士(スポーツ科学) ( 早稲田大学 )

Research Experience

  • 2021.04
    -
    Now

    Waseda University   Faculty of Sport Sciences

  • 2021.04
    -
    2022.03

    Yokohama College of Commerce   Yokohama College of Commerce

  • 2019.04
    -
    2021.03

    Yokohama College of Commerce   Yokohama College of Commerce Department of Management Information

Education Background

  • 2016.04
    -
    2019.03

    Waseda University   Graduate School of Sport Sciences  

Professional Memberships

  •  
     
     

    European College of Sport Science

  •  
     
     

    THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE

Research Areas

  • Clinical pharmacy / Physiology / Nutrition science and health science

Research Interests

  • 動脈圧受容器

  • 運動昇圧反射

  • トレーニング

  • 動脈硬化

  • 循環器

  • 生理学

  • 運動生理学

▼display all

Awards

  • 濱野吉生記念褒賞

    2019.03   早稲田大学スポーツ科学研究科  

    Winner: 中村 宣博

 

Papers

  • The interaction of breath holding and muscle mechanoreflex on cardiovascular responses in breath-hold divers and non-breath-hold divers.

    Nakamura Nobuhiro, Peng Heng, Hayashi Naoyuki

    European journal of applied physiology    2024.03  [International journal]

     View Summary

    Cardiovascular responses to diving are characterized by two opposing responses: tachycardia resulting from exercise and bradycardia resulting from the apnea. The convergence of bradycardia and tachycardia may determine the cardiovascular responses to diving. The purpose of this study was to investigate the interaction of breath holding and muscle mechanoreflex on cardiovascular responses in breath-hold divers (BHDs) and non-BHDs. We compared the cardiovascular responses to combined apnea and the mechanoreflex in BHDs and non-BHDs. All participants undertook three trials-apnea, passive leg cycling (PLC), and combined trials-for 30 s after rest. Cardiovascular variables were measured continuously. Nine BHD (male:female, 4:5; [means ± SD] age, 35 ± 6 years; height, 168.6 ± 4.6 cm; body mass, 58.4 ± 5.9 kg) and eight non-BHD (male:female, 4:4; [means ± SD] age, 35 ± 7 years; height, 163.9 ± 9.1 cm; body mass, 55.6 ± 7.2 kg) participants were included. Compared to the resting baseline, heart rate (HR) and cardiac output (CO) significantly decreased during the combined trial in the BHD group, while they significantly increased during the combined trials in the non-BHD group (P < 0.05). Changes in the HR and CO were significantly lower in the BHD group than in the non-BHD group in the combined trial (P < 0.05). These results suggest that bradycardia with apnea in BHDs is prioritized over tachycardia with the mechanoreflex, whereas that in non-BHDs is not. This finding implies that diving training changes the interaction between apnea and the mechanoreflex in cardiovascular control.

    DOI PubMed

  • Acute social jetlag augments morning blood pressure surge: a randomized crossover trial.

    Nobuhiro Nakamura, Hiroshi Akiyama, Mei Nishimura, Kejing Zhu, Katsuhiko Suzuki, Mitsuru Higuchi, Kumpei Tanisawa

    Hypertension research : official journal of the Japanese Society of Hypertension    2023.07  [International journal]

     View Summary

    Although social jetlag (SJL) is generally considered a chronic condition, even acute SJL may have unfavorable effects on the cardiovascular system. We focused on the acute effects of SJL on morning blood pressure (BP) surge. This randomized crossover trial recruited 20 healthy men. In the SJL trial, participants delayed their bedtime by three hours on Friday and Saturday nights. Participants in the control (CON) trial implemented the same sleep-wake timing as on weekdays. Pre- and post-intervention measurements were performed to evaluate resting cardiovascular variables on Friday and Monday mornings, respectively. The ambulatory BP was automatically measured during the sleep and awake periods for 2 h after the participant woke up at night before pre- and post-intervention measurements. SJL (average mid-sleep time on weekends - average mid-sleep time on weekdays) occurred only in the SJL trial (SJL: 181 ± 24 min vs. CON: 8 ± 47 min). Carotid-femoral pulse wave velocity (cfPWV) and morning BP surge on Monday in the SJL trial were significantly higher than those on Friday in the SJL trial (cfPWV: P = 0.001, morning BP surge: P < 0.001), and those on Monday in the CON trial (cfPWV: P = 0.007; morning BP surge: P < 0.001). Furthermore, a significant positive correlation was found between ΔcfPWV and Δmorning BP surge (R = 0.587, P = 0.004). These results suggest that even acute SJL augments morning BP surge. This phenomenon may correspond to increased central arterial stiffness.State the details of Clinical Trials: Name: Effect of acute social jetlag on risk factors of lifestyle-related diseases. URL: https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000053204 . Unique identifier: UMIN000046639. Registration date: 17/01/2022.

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  • Associations between cardiorespiratory fitness and lifestyle-related factors with DNA methylation-based aging clocks in older men: WASEDA’S Health Study

    Takuji Kawamura, Zsolt Radak, Hiroki Tabata, Hiroshi Akiyama, Nobuhiro Nakamura, Ryoko Kawakami, Tomoko Ito, Chiyoko Usui, Matyas Jokai, Ferenc Torma, Hyeon-Ki Kim, Motohiko Miyachi, Suguru Torii, Katsuhiko Suzuki, Kaori Ishii, Shizuo Sakamoto, Koichiro Oka, Mitsuru Higuchi, Isao Muraoka, Kristen M. McGreevy, Steve Horvath, Kumpei Tanisawa

       2023.04

     View Summary

    Abstract

    DNA methylation-based age estimators (DNAm aging clocks) are currently one of the most promising biomarkers for predicting biological age. However, the relationships between objectively measured physical fitness, including cardiorespiratory fitness, and DNAm aging clocks are largely unknown. We investigated the relationships between physical fitness and the age-adjusted value from the residuals of the regression of DNAm aging clock to chronological age (DNAmAgeAcceleration: DNAmAgeAccel) and attempted to determine the relative contribution of physical fitness variables to DNAmAgeAccel in the presence of other lifestyle factors. DNA samples from 144 Japanese men aged 65–72 years were used to calculate first- (i.e., DNAmHorvath and DNAmHannum) and second- (i.e., DNAmPhenoAge, DNAmGrimAge and DNAmFitAge) generation DNAm aging clocks. Various surveys and measurements were conducted, including physical fitness, body composition, blood biochemical parameters, nutrients intake, smoking, alcohol consumption, disease status, sleep status, and chronotype. The peak oxygen uptake (VO2peak) per kg body weight had a significant negative correlation with GrimAgeAccel (r= -0.222,p= 0.008). A comparison of the tertile groups showed that the GrimAgeAccel of the highest VO2peakgroup was decelerated by 1.6 years compared to the lowest group (p= 0.035). Multiple regression analysis suggested that rather than physical fitness, serum triglycerides, carbohydrate intake, and smoking status, were significantly associated with DNAmAgeAccel. In conclusion, the contribution of cardiorespiratory fitness to DNAmAgeAccel was relatively low compared to lifestyle factors such as smoking. However, this study reveals a negative relationship between cardiorespiratory fitness and DNAmAgeAccel in older men.

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  • Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study

    Nobuhiko Eda, Saki Tsuno, Nobuhiro Nakamura, Ryota Sone, Takao Akama, Mitsuharu Matsumoto

    Nutrients   14 ( 22 ) 4875 - 4875  2022.11  [Refereed]  [International journal]

     View Summary

    This study aimed to examine the effects of hydrogen gas (H2) produced by intestinal microbiota on participant conditioning to prevent intense exercise-induced damage. In this double-blind, randomized, crossover study, participants ingested H2-producing milk that induced intestinal bacterial H2 production or a placebo on the trial day, 4 h before performing an intense exercise at 75% maximal oxygen uptake for 60 min. Blood marker levels and respiratory variables were measured before, during, and after exercise. Visual analog scale scores of general and lower limb muscle soreness evaluated were 3.8- and 2.3-fold higher, respectively, on the morning after treatment than that before treatment during the placebo trial, but not during the test beverage consumption. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations and production rates significantly increased with placebo consumption; no changes were observed with test beverage consumption. After exercise, relative blood lactate levels with H2-producing milk consumption were lower than those with placebo consumption. A negative correlation was observed between the variation of 8-OHdG and the area under the curve (AUC) of breath H2 concentrations. Lipid oxidation AUC was 1.3-fold higher significantly with H2-producing milk than with placebo consumption. Conclusively, activating intestinal bacterial H2 production by consuming a specific beverage may be a new strategy for promoting recovery and conditioning in athletes frequently performing intense exercises.

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  • Muscle Stretching Induces the Mechanoreflex Response in Human Arterial Blood Pressure

    Nobuhiro Nakamura, Peng Heng, Naoyuki Hayashi

    Journal of Applied Physiology    2022.11  [Refereed]

     View Summary

    Introduction The muscle mechanoreflex has been considered to make a small contribution to the cardiovascular response to exercise in healthy humans because no pressor response has been observed during stimulation of mechanosensitive receptors, such as static passive stretching, during many human studies. There is room for rethinking this consideration since the pressor response to upper limb exercise is greater than that to lower limb exercise. We examined whether static passive stretching of the forearm muscles causes a muscle mechanoreflex-induced pressor response in humans. Methods Eighteen healthy men were recruited for this study. After a 15-min rest period in the supine position with a neutral (0°) wrist joint angle, all participants completed static passive stretching of the forearm for 60s at four different intensities: minimal painful passive stretching (PPS); moderate-intensity passive stretching (MPS); low-intensity passive stretching (LPS); and no load (NL). During the procedure, beat-to-beat arterial blood pressure was measured using finger photoplethysmography. The force generated between the passively stretched hand and the experimenter's hands was recorded using a force transducer. Results Mean arterial pressure (MAP) during PPS and MPS significantly increased from baseline during the last 40s (P &lt; 0.05). MAP was significantly greater at 50s and 60s, depending on the intensity. MPS induced a greater peak response in MAP than lower intensities (P &lt; 0.05). None of the subjects reported pain during the MPS and LPS trials. Conclusion Static passive stimulation of the forearm is an effective method of isolating the muscle mechanoareflex-induced pressor response in humans.

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  • Changes in the skin characteristics associated with dehydration and rehydration.

    Nobuhiko Eda, Nobuhiro Nakamura, Yuto Inai, Ziyue Sun, Ryota Sone, Koichi Watanabe, Takao Akama

    European journal of sport science     1 - 20  2022.02  [Refereed]  [International journal]

     View Summary

    AbstractThe present study aimed to test the hypothesis that changes in the dermal tissue dielectric constant (TDC) and biomechanical properties of the skin would be correlated with the indicators related to dehydration. Ten healthy adult men were enrolled in three trials: no fluid intake (DEH), ad libitum fluid intake (AL-HYD), and programmed fluid intake (P-HYD) after exercise in a randomized crossover design. The participants performed a pedaling exercise at 60% heart rate reserve until 2% body mass loss. At 120 min after exercise, an incremental exercise test was carried out. Aerobic capacity, body composition, TDC, biomechanical properties of the skin (pliability, viscoelasticity, and total recovery), and indicators related to dehydration in the serum and urine were measured before and 120 min after exercise. Higher values of the pliability and viscoelasticity, and lower value of the total recovery on the hand were demonstrated in the P-HYD trial compared to the DEH trial (all P < 0.05). Changes in the TDC were significantly correlated with changes in body mass (P < 0.05), total body water (P < 0.05), serum osmolarity (P < 0.05), and hematocrit (P < 0.01). Changes in the biomechanical properties of the hand were significantly correlated with changes in body mass, hematocrit, and urine specific gravity (all P < 0.05). The present study showed that the changes in skin characteristics correlated with the body water and dehydration-associated indicators in the serum and urine, thus suggesting that skin characteristics may be useful in the assessment of dehydration.

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  • Impact of acute dynamic exercise on vascular stiffness in the retinal arteriole in healthy subjects.

    Tsukasa Ikemura, Nobuhiro Nakamura, Naoyuki Hayashi

    Journal of applied physiology (Bethesda, Md. : 1985)   132 ( 2 ) 459 - 468  2022.02  [Refereed]  [International journal]

     View Summary

    Acute exercise can improve vascular stiffness in the conduit artery, but its effect on the retinal arterioles is unknown. The present study investigated the effects of acute dynamic exercise on retinal vascular stiffness. In experiment 1, we measured the cardio-ankle vascular index (CAVI), carotid artery intima-media thickness (carotid IMT), and retinal blood velocity by laser speckle flowgraphy in 28 healthy old and 28 young men (69 ± 3 and 23 ± 3 yr, respectively). Pulse waveform variables, which were used as an index of retinal vascular stiffness, were assessed by retinal blood flow velocity profile analysis. In experiment 2, 18 healthy old and 18 young men (69 ± 3 and 23 ± 3 yr, respectively) underwent assessment of pulse waveform variables after a 30-min bout of moderate cycling exercise at an intensity of 60% heart rate reserve. There was a significant difference in the baseline pulse waveform variables between the old and young groups. Pulse waveform variables in the retinal arteriole did not significantly change after acute dynamic exercise, whereas CAVI significantly decreased. These findings suggest that retinal vascular stiffness does not change by acute exercise. The effect of exercise on vascular stiffness in the retinal arterioles might be different from that in the conduit artery.NEW & NOTEWORTHY Acute dynamic exercise is well known to improve vascular stiffness in the conduit artery while its effect on the retinal arterioles has been unknown. This study showed that an acute dynamic exercise does not change vascular stiffness in the retinal arteriole in healthy humans. Different responses to acute dynamic exercise in vascular stiffness in retinal arterioles and conduit arteries are suggested.

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  • Muscle stiffening is associated with muscle mechanoreflex-mediated cardioacceleration

    Nobuhiro Nakamura, Naoki Ikeda, Peng Heng, Isao Muraoka

    European Journal of Applied Physiology   122 ( 3 ) 781 - 790  2022.01  [Refereed]  [International journal]

     View Summary

    PURPOSE: Although the muscle mechanoreflex is an important mediator to cardiovascular regulation during exercise, its modulation factors remain relatively unknown. Therefore, the purpose of this study was to investigate the effect of muscle stiffness on the muscle mechanoreflex. METHODS: Participants were divided based on their median muscle stiffness (2.00 Nm/mm) into a low group (n = 15) and a high group (n = 15), and the muscle mechanoreflex was compared between the groups. After a 15-min rest in the supine position, heart rate (HR), blood pressure (BP), stroke volume (SV), and cardiac output (CO) were measured at rest for 3 min and during static passive dorsiflexion (SPD) at 20° for 1 min. Following a 15-min re-rest, muscle stiffness and passive resistive torque were evaluated in the distal end of the muscle belly of the medial gastrocnemius. RESULTS: Peak relative changes in HR (low group: 6 ± 4% and high group: 12 ± 4%) and CO (low group: 8 ± 10% and high group: 13 ± 9%) were greater in the high group than in the low group (both, P < 0.05). A significant positive correlation was found between resistive torque during SPD and muscle stiffness and peak relative changes in HR (r = 0.51 and 0.61, both P < 0.05). However, there was no correlation between muscle elongation during SPD and peak relative changes in HR (r = - 0.23, P = 0.20). CONCLUSION: These findings suggest that muscle stiffness may be modulatory factor of muscle mechanoreflex.

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  • Effects of changes in large arterial compliance and small arterial buffer function with resistance training on cerebral blood flow pulsatility

    Nobuhiro Nakamura, Takafumi Kubo, Isao Muraoka

    GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE   180 ( 12 ) 805 - 814  2021.12

     View Summary

    BACKGROUND: Cerebral blood flow (CBF) pulsatility is dampened by large and small arterial buffer functions. Resistance training (RT) improved small arterial buffer function regardless of impaired large arterial compliance. This response to small arterial buffer function with RT may be compensatory adaptation to impaired large arterial compliance for protecting end-organs such as the brain from excessive pulsatile stresses. This study aimed to investigate the effects of changes in large arterial compliance and small arterial buffer functions with RT on CBF pulsatility.METHODS: Twenty healthy men were assigned to either the RT group (N.=10) or the control (CON) group (N.=10). Subjects in the RT group exercised three times/week for 8 weeks. Arterial compliance of common carotid artery was measured as an index of large arterial compliance. Dampening factor (DF) in the cerebral artery and pulsatility index (PI) in the middle cerebral artery (MCA) were used to evaluate small arterial buffer function and CBF pulsatility, respectively.RESULTS: In the RT group, arterial compliance significantly decreased (P<0.05) and DF in the cerebral artery signifi-cantly increased (P<0.05) after intervention compared to baseline. However, there was no change in PI in MCA in both groups. A negative correlation was found between Delta arterial compliance and Delta DF in the cerebral artery (r=-0.671, P<0.05).CONCLUSIONS: These results may suggest that the response of small arteries to RT is a compensatory adaptation to impaired large arterial compliance for protecting end organs from excessive pulsatile stresses.

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  • Effects of Greater Central Arterial Stiffness on Cardiovagal Baroreflex Sensitivity in Resistance-Trained Men

    Nobuhiro Nakamura, Isao Muraoka

    Sports Medicine - Open   7 ( 1 )  2021.12  [Refereed]

     View Summary

    <title>Abstract</title><sec>
    <title>Background</title>
    Compared with age-matched untrained men, resistance-trained men who have undergone long duration training (&gt; 2 years) at a high frequency (&gt; 5 days/week) may be lower cardiovagal baroreflex sensitivity (BRS) because of central arterial stiffening. Therefore, the purpose of this study was to examine the effect of greater central arterial stiffness in resistance-trained men on cardiovagal BRS in a cross-sectional study to compare resistance-trained men with age-matched untrained men.


    </sec><sec>
    <title>Methods</title>
    This cross-sectional study included resistance-trained men (<italic>n</italic> = 20; age: 22 ± 3; body mass index: 26.7 ± 2.2) and age-matched untrained men (control group: <italic>n</italic> = 20; age: 25 ± 2; body mass index: 23.7 ± 2.4). The β-stiffness index and arterial compliance were assessed at the right carotid artery using a combination of a brightness mode ultrasonography system for the carotid artery diameter and applanation tonometry for the carotid blood pressure. And, the cardiovagal BRS was estimated by the slope of the R–R interval and systolic blood pressure during Phase II and IV of Valsalva maneuver (VM). The participants maintained an expiratory mouth pressure of 40 mmHg for 15 s in the supine position.


    </sec><sec>
    <title>Results</title>
    The β-Stiffness index was significantly higher in the resistance-trained group than in the control group (5.9 ± 1.4 vs. 4.4 ± 1.0 a.u., <italic>P</italic> &lt; 0.01). In contrast, the resistance-trained group had significantly lower arterial compliance (0.15 ± 0.05 vs. 0.20 ± 0.04 mm2/mmHg, <italic>P</italic> &lt; 0.01) and cardiovagal BRS during Phase IV of VM (9.0 ± 2.5 vs. 12.9 ± 5.4 ms/mmHg, <italic>P</italic> &lt; 0.01) than the control group and. Moreover, cardiovagal BRS during Phase IV of VM was inversely and positively correlated with the β-stiffness index (<italic>r</italic> = − 0.59, <italic>P</italic> &lt; 0.01) and arterial compliance (<italic>r</italic> = 0.64, <italic>P</italic> &lt; 0.01), respectively.


    </sec><sec>
    <title>Conclusion</title>
    Resistance-trained group had greater central arterial stiffness and lower cardiovagal BRS Phase IV compared with control group. Moreover, the central arterial stiffening was related to cardiovagal BRS Phase IV. These results suggest that greater central arterial stiffness in resistance-trained men may be associated with lower cardiovagal BRS.


    <italic>Trial Registration</italic> University hospital Medical Information Network (UMIN) in Japan, UMIN000038116. Registered on September 27, 2019.


    </sec>

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  • The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males.

    Takaki Tominaga, Tsukasa Ikemura, Koichi Yada, Kazue Kanda, Kaoru Sugama, Sihui Ma, Wonjun Choi, Mayu Araya, Jiapeng Huang, Nobuhiro Nakamura, Katsuhiko Suzuki

    Antioxidants (Basel, Switzerland)   10 ( 6 )  2021.05  [Refereed]  [International journal]

     View Summary

    Strenuous exercise induces organ damage, inflammation and oxidative stress. To prevent exercise-induced organ damage, inflammation and oxidative stress, rehydrating may be an effective strategy. In the present study, we aimed to examine whether beverage intake after exhaustive exercise to recover from dehydration prevents such disorders. Thirteen male volunteers performed incremental cycling exercise until exhaustion. Immediately after exercise, the subjects drank an electrolyte containing water (rehydrate trial: REH) or did not drink any beverage (control trial: CON). Blood samples were collected before (Pre), immediately (Post), 1 h and 2 h after exercise. Urine samples were also collected before (Pre) and 2 h after exercise. We measured biomarkers of organ damage, inflammation and oxidative stress in blood and urine. Biomarkers of muscle, renal and intestinal damage and inflammation increased in the blood and urine after exercise. However, changes in biomarkers of organ damage and inflammation did not differ between trials (p > 0.05). The biomarker of oxidative stress, thiobarbituric acid reactive substances (TBARS), in plasma, showed different changes between trials (p = 0.027). One hour after exercise, plasma TBARS concentration in REH had a higher trend than that in CON (p = 0.052), but there were no significant differences between Pre and the other time points in each trial. These results suggest that beverage intake after exercise does not attenuate exercise-induced organ damage, inflammation or oxidative stress in healthy males. However, rehydration restores exercise-induced oxidative stress more quickly.

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  • Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA'S Health Study.

    Takuji Kawamura, Kumpei Tanisawa, Ryoko Kawakami, Chiyoko Usui, Tomoko Ito, Hiroki Tabata, Nobuhiro Nakamura, Sayaka Kurosawa, Wonjun Choi, Sihui Ma, Zsolt Radak, Susumu S Sawada, Katsuhiko Suzuki, Kaori Ishii, Shizuo Sakamoto, Koichiro Oka, Mitsuru Higuchi, Isao Muraoka

    Oxidative medicine and cellular longevity   2021   5566880 - 5566880  2021  [Refereed]  [International journal]

     View Summary

    Previous studies have not investigated the determinants of resting oxidative stress, including physical fitness, as it relates to redox regulation. The present study therefore was aimed at identifying lifestyle and biological factors that determine resting oxidative stress, including objectively measured physical fitness. In 873 middle-aged and elderly men and women, age and anthropometric parameters, lifestyle-related parameters, medication and supplementation status, physical fitness, biochemical parameters, and nutritional intake status, as well as three plasma oxidative stress markers: protein carbonyl (PC), F2-isoprostane (F2-IsoP), and thiobarbituric acid reactive substances (TBARS), were surveyed and measured. The determinants of PC, F2-IsoP, and TBARS in all participants were investigated using stepwise multiple regression analysis. In PC, age (β = -0.11, P = 0.002), leg extension power (β = -0.12, P = 0.008), BMI (β = 0.12, P = 0.004), and HDL-C (β = 0.08, P = 0.040) were included in the regression model (adjusted R 2 = 0.018). In the F2-IsoP, smoking status (β = 0.07, P = 0.060), BMI (β = 0.07, P = 0.054), and HbA1c (β = -0.06, P = 0.089) were included in the regression model (adjusted R 2 = 0.006). In TBARS, glucose (β = 0.18, P < 0.001), CRF (β = 0.16, P < 0.001), age (β = 0.15, P < 0.001), TG (β = 0.11, P = 0.001), antioxidant supplementation (β = 0.10, P = 0.002), and HbA1c (β = -0.13, P = 0.004) were included in the regression model (adjusted R 2 = 0.071). In conclusion, the present study showed that age, anthropometric index, lifestyle-related parameters, medication and supplementation status, objectively measured physical fitness, biochemical parameters, and nutritional intake status explain less than 10% of oxidative stress at rest.

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  • Tape stripping method is useful for the quantification of antimicrobial peptides on the human skin surface including the stratum corneum.

    Shigeyuki Ono, Nobuhiko Eda, Takuya Mori, Atsuko Otsuka, Nobuhiro Nakamura, Yuto Inai, Noriyasu Ota, Takao Akama

    Scientific reports   10 ( 1 ) 15259 - 15259  2020.09  [International journal]

     View Summary

    Antimicrobial peptides (AMPs) play an important role in innate immunity in human skin. It is known that AMPs mainly function in the stratum corneum. Therefore, AMP concentrations in the stratum corneum need to be precisely measured to clarify functional and physiological importance of AMPs in cutaneous defence. Tape stripping (TS) is a well-established method by which components in the stratum corneum can be collected. However, the usefulness of the TS method for measuring AMP concentration in human skin remains unclear. Therefore, we compared it with another popular method, skin rinsing, which had been established as a method for measuring AMP concentration in human skin. When investigated on healthy medial forearm using RNase 7, which is one of the typical AMPs, as an index, there was a significant positive correlation between RNase 7 concentrations measured by the TS method at adjacent forearm sites, demonstrating the reproducibility of the TS method. Next, a significant positive correlation was detected in RNase 7 concentrations measured using the TS and the skin rinsing method, indicating that the TS method is comparable to the skin rinsing method. Thus, we speculate that the TS method is useful for measuring AMP concentration in human skin.

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  • Influence of different preceding exercises on fat metabolism during subsequent endurance exercise

    Ryosuke Fujii, Nobuhiro Nakamura, Takuji Kawamura, Tsukasa Ikemura, Masayuki Konishi, Katsuhiko Suzuki, Shizuo Sakamoto, Isao Muraoka

    GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE   179 ( 6 ) 393 - 403  2020.06  [Refereed]

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    BACKGROUND: Preceding exercise enhances fat metabolism during subsequent endurance exercise. However, it is unknown which type of exercise most enhances fat metabolism during subsequent exercise. The aim of this study was to examine the influence of preceding resistance or endurance exercise on fat metabolism during subsequent endurance exercise and to compare the effect with that without a preceding exercise.METHODS: Nine male subjects performed the following trials: 1) endurance exercise (E trial), 2) endurance exercise preceded by resistance exercise (R+E trial), and 3) endurance exercise preceded by endurance exercise (E+E trial). There was a 20-min break after the preceding exercise. Subsequent endurance exercise was performed on a cycle ergometer at 80% of the individual ventilatory threshold. Blood and exhaled gas were analyzed respectively.RESULTS: The R+E and E+E trials showed a significantly lower respiratory exchange ratio (RER) and a higher amount of fat oxidation during endurance exercise than those in the E trial (P<0.05). Furthermore, the E+E trial showed a significantly lower RER (0.86 +/- 0.03 vs. 0.84 +/- 0.02) and a significantly higher amount of fat oxidation (0.38 +/- 0.05 g/min vs. 0.44 +/- 0.08 g/min) than those in the R+E trial.CONCLUSIONS: This study suggested that fat oxidation during subsequent endurance exercise was enhanced when a preceding exercise was performed and that endurance exercise as a preceding exercise enhanced fat oxidation more than resistance exercise did.

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  • Acute effect of increased arterial stiffness with high-intensity resistance exercise on cerebral blood flow

    Nobuhiro Nakamura, Tsukasa Ikemura, Isao Muraoka

    GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE   178 ( 4 ) 195 - 202  2019.04  [Refereed]

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    BACKGROUND: Increased arterial stiffness decreases cerebral blood flow (CBF), which plays a vital role in the maintenance of life and cognitive function. Previous studies have shown that high-intensity resistance exercise (HRE) increases arterial stiffness. HRE may decrease cerebral blood flow. However, the effect of increased arterial stiffness associated with HRE on CBF is not fully elucidated. Therefore, this study aimed to investigate the effect of increased arterial stiffness with HRE on CBF.METHODS: Study participants included 8 healthy young men. All subjects performed three exercise trials in a crossover design: HRE, low-intensity resistance exercise (LRE), and aerobic exercise (AE). beta-stiffness index was measured as an index of arterial stiffness, and global cerebral blood flow was measured as an index of cerebral blood flow. These were measured at rest, immediately after exercise, and 10 minutes post-exercise.RESULTS: Global cerebral blood flow was significantly increased immediately after and 10 minutes after AE. In contrast, a significant decrease of global cerebral blood flow was observed immediately after and 10 minutes following HRE. However, no changes were observed in LRE. With HRE, beta-stiffness index was significantly increased immediately after and 10 minutes post-exercise. In contrast, no differences were observed in arterial stiffness associated with aerobic exercise and LRE. A negative correlation was found between global cerebral blood flow and arterial stiffness at rest and immediately after and 10 minutes post-exercise.CONCLUSIONS: These results suggested that HRE increased arterial stiffness and decreased cerebral blood flow.

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  • Effect of accommodating elastic bands on mechanical power output during back squats.

    Kubo T, Hirayama K, Nakamura N, Higuchi M

    Sports (Basel)   6 ( 4 )  2018.11  [Refereed]  [International journal]

     View Summary

    The aim of this study was to investigate whether accommodating elastic bands with barbell back squats (BSQ) increase muscular force during the deceleration subphase. Ten healthy men (mean ± standard deviation: Age: 23 ± 2 years; height: 170.5 ± 3.7 cm; mass: 66.7 ± 5.4 kg; and BSQ one repetition maximum (RM): 105 ± 23.1 kg; BSQ 1RM/body mass: 1.6 ± 0.3) were recruited for this study. The subjects performed band-resisted parallel BSQ (accommodating elastic bands each sides of barbell) with five band conditions in random order. The duration of the deceleration subphase, mean mechanical power, and the force and velocity during the acceleration and deceleration subphases were calculated. BSQ with elastic bands elicited greater mechanical power output, velocity, and force during the deceleration subphase, in contrast to that elicited with traditional free weight (p < 0.05). BSQ with elastic bands also elicited greater mechanical power output and velocity during the acceleration subphase. However, the force output during the acceleration subphase using an elastic band was lesser than that using a traditional free weight (p < 0.05). This study suggests that BSQ with elastic band elicit greater power output during the acceleration and deceleration subphases.

    DOI PubMed

    Scopus

    3
    Citation
    (Scopus)
  • Influence of different loads on force-time characteristics during back squats

    Kubo T, Hirayama K, Nakamura N, Higuchi M

    Journal of Sports Science and Medicine   17 ( 4 ) 617 - 622  2018.11  [Refereed]  [International journal]

     View Summary

    The deceleration sub-phase during the back squat (BSQ) makes it difficult to stimulate the muscles throughout the full range of motion, and it has only been reported for one load during BSQ. The purpose of this study was to investigate whether a deceleration sub-phase occurs during BSQ with different loads and to assess the influence of load on the deceleration sub-phase duration and negative impulse during the deceleration sub-phase. Sixteen healthy men (mean ± standard deviation: age: 25 ± 3 years; height: 1.73 ± 0.07 m; mass: 83.2 ± 16.1 kg; BSQ one repetition maximum (1RM): 163.8 ± 36.6 kg; BSQ 1RM/body weight: 2.0 ± 0.4) who had performed resistance training for at least 1 year were recruited for this study. The subjects performed parallel BSQ with 0%, 12%, 27%, 42%, 56%, 71%, and 85% of each 1RM on a force plate in a random order. The deceleration sub-phase duration and negative impulse during the deceleration sub-phase were calculated from force-time data. The absolute durations of the deceleration sub-phase were not significantly different according to load except for 27% 1RM and 85% 1RM (p = 0.01). However, as the load increased from 12 to 85% 1RM, the relative duration of the deceleration sub-phase decreased (p < 0.05). The negative impulse during the deceleration sub-phase also increased from 0 to 42% 1RM (p < 0.05). A deceleration sub-phase occurs regardless of the load (0%-85% 1RM), and a large portion of the deceleration sub-phase occupied the concentric phase, with low-moderate loads, and a large amount of negative impulse occurred during the short deceleration sub-phase with a high load.

    PubMed

  • Breath acetone excretion during graded exercise and moderate-intensity aerobic exercise

    中村宣博, 藤井亮輔, 池村司, 村岡功

    日本運動生理学雑誌   25 ( 2 ) 31 - 40  2018.11  [Refereed]

    J-GLOBAL

  • Resistance training augments cerebral blood flow pulsatility: cross-sectional study.

    Nakamura N, Muraoka I

    American Journal of Hypertension   31 ( 7 ) 811 - 817  2018.07  [Refereed]  [International journal]

     View Summary

    BACKGROUND: Increased central arterial stiffness and/or decreased compliance reduces buffer function and increases cerebral blood flow (CBF) pulsatility, which leads to increased cerebral microvascular damage, resulting in the augmentation of the risk of cerebrovascular diseases. Resistance-trained men showed higher central arterial stiffness and lower arterial compliance than age-matched, sedentary men. This study examined the effect of increased central arterial stiffness and/or decreased arterial compliance on CBF pulsatility. METHODS: The study participants included 31 young healthy men (15 resistance-trained men, aged 21 ± 1 years; and 16 controls, aged 23 ± 1 years). β-Stiffness index and arterial compliance were measured in the right carotid artery as index of central arterial stiffness and compliance, respectively. The pulsatility index (PI) was measured in the middle cerebral artery as index of CBF pulsatility. RESULTS: β-Stiffness index and PI were significantly higher in the resistance-trained group than in the control group (β-stiffness index: 5.3 ± 0.3 vs. 3.5 ± 0.3 a.u., P < 0.05, PI: 0.80 ± 0.02 vs. 0.70 ± 0.02, P < 0.05). The resistance-trained group showed significantly lower arterial compliance than the control group (0.16 ± 0.01 vs. 0.23 ± 0.01 mm2/mm Hg, P < 0.05). Positive and negative correlations were observed between β-stiffness index and PI (r = 0.39, P < 0.05), and between arterial compliance and PI (r = -0.59, P < 0.05), respectively. CONCLUSIONS: The resistance-trained group showed higher central arterial stiffness and PI and lower arterial compliance. Central arterial stiffness and arterial compliance were associated with PI. Increased arterial stiffness and decreased arterial compliance with resistance training impair buffer function, resulting in increased CBF pulsatility. CLINICAL TRIAL REGISTRATION: Trial Number UMIN000023816 URL: http://www.umin.ac.jp/icdr/index.html Official scientific title of the study: effect of increase arterial stiffness by resistance training on cerebral hemodynamic.

    DOI PubMed

    Scopus

    6
    Citation
    (Scopus)
  • Fluid intake restores retinal blood flow early after exhaustive exercise in healthy subjects.

    Tsukasa Ikemura, Katsuhiko Suzuki, Nobuhiro Nakamura, Koichi Yada, Naoyuki Hayashi

    European journal of applied physiology   118 ( 5 ) 1053 - 1061  2018.05  [Refereed]  [International journal]

     View Summary

    PURPOSE: It remains unclear whether rehydration restores retinal blood flow reduced by exhaustive exercise. We investigated the effect of fluid intake on retinal blood flow after exhaustive exercise. METHODS: Blood flow in the inferior (ITRA) and superior temporal retinal arterioles (STRA) was measured before and after incremental cycling exercise until exhaustion in 13 healthy males. After the exercise, the subjects rested without drinking (control condition: CON) or with drinking an electrolyte containing water (rehydrate condition: REH) and were followed up for a period of 120 min. To assess the hydration state, the body mass was measured, and venous blood samples were collected and plasma volume (PV) was calculated. RESULTS: Body mass decreased in CON after the trial [- 1.1 ± 0.1% (mean ± SE), p < 0.05]. PV was lower in CON than in REH during recovery. The ITRA and STRA blood flows decreased immediately after exercise from the resting baseline (ITRA; - 23 ± 4% in REH and - 30 ± 4% in CON, p < 0.05). The ITRA blood flow recovered baseline level at 15 min of recovery in REH (- 9 ± 3%, p = 0.5), but it remained reduced in CON (-14 ± 3%, p < 0.05). The STRA blood flow was higher in REH than in CON at 15 min (2 ± 3 vs. - 5 ± 3%, p < 0.05). CONCLUSIONS: The results of this study suggest that the reduction in retinal blood flow induced by exhaustive exercise can be recovered early by rehydration.

    DOI PubMed

    Scopus

    2
    Citation
    (Scopus)
  • Relationship Between Acetone Excretion in Exhaled Breath and Fat Oxidation During Rest

    藤井亮輔, 中村宣博, 池村司, 村岡功

    日本運動生理学雑誌   24 ( 1 ) 1 - 6  2017.03  [Refereed]

    J-GLOBAL

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Presentations

  • Parasympathetic nervous regulation and prevalence of lifestyle-related diseases in Japanese: WASEDA'S Health Study

    Masayuki Konishi, Susumu S. Sawada, Ryoko Kawakami, Kumpei Tanisawa, Hiroki Tabata, Nobuhiro Nakamura, Hyeon-Ki Kim, Tomoko Ito, Mitsuru Higuchi, Katsuhiko Suzuki, Suguru Torii, I-Min Lee F, Steven N. Blair, Koichiro Oka, Shizuo Sakamoto

    66th Annual Meeting of the American College of Sports Medicine 

    Presentation date: 2019.05

  • Cardiorespiratory fitness and prevalence of lifestyle-related diseases in Japanese men and womenWASEDA’S Health Study

    Susumu S. Sawada, Ryoko Kawakami, Kumpei Tanisawa, Hiroki Tabata, Nobuhiro Nakamura, Hyeon-Ki Kim, Masayuki Konishi, Tomoko Ito, Chiyoko Usui, Taishi Midorikawa, Mitsuru Higuchi, Katsuhiko Suzuki, Suguru Torii, I-Min Lee, Steven N. Blair, Isao Muraoka, Kaori Ishii, Koichiro Oka, Shizuo Sakamoto

    66th Annual Meeting of the American College of Sports Medicine 

    Presentation date: 2019.05

  • 中高齢男女における潜水徐脈および運動後心拍回復と生活習慣病有病率の関係:WASEDA'S Health Study

    小西 真幸, 澤田 享, 川上 諒子, 谷澤 薫平, 田端 宏樹, 中村 宣博, 金 鉉基, 伊藤 智子, 樋口 満, 鈴木 克彦, 鳥居 俊, 村岡 功, 石井 香織, 岡 浩一朗, 坂本 静男

    第6回介護予防・健康 づくり学会大会 

    Presentation date: 2018.11

  • 日本人中高齢者における全身持久力と生活習慣病有病率の関係-WASEDA'S Health Study-

    澤田 享, 川上 諒子, 谷澤 薫平, 田端 宏樹, 中村 宣博, 金 鉉基, 小西 真幸, 伊藤 智子, 薄井 澄誉子, 緑川 泰史, 樋口 満, 鈴木 克 彦, 鳥居 俊, 村岡 功, 石井 香織, 岡 浩一朗, 坂本 静男

    第6回介護予防・健康 づくり学会大会 

    Presentation date: 2018.11

  • 腸内水素ガス産生乳飲料の摂取が高強度運動後の酸化ストレス応答に及ぼす影響

    枝 伸彦, 中村 宣博, 曽根 良太, 松本 光晴, 赤間 高雄

    第73回日 本体力医学会大会 

    Presentation date: 2018.09

  • 朝または夕の12週間の持久性運動が炎症・抗炎症サイトカインに及ぼす影響

    金 鉉基, 小西 真幸, 田端 宏樹, 中村 宣博, 髙橋 将記, 柴田 重信, 坂本 静男

    第 73 回日本体力医学会大会 

    Presentation date: 2018.09

  • レジスタンストレーニングが中心および末梢動脈の血流拍動性緩衝能に及ぼす影響

    中村 宣博, 久保 孝史, 村岡 功

    第73回日本体力医学会大会 

    Presentation date: 2018.09

  • Effect of increased central arterial stiffness with resistance training on cerebral blood flow pulsatility.

    Nakamura N, Kubo T, Muraoka I

    23rd annual congress of the european college of sport science in Dublin/Ireland 

    Presentation date: 2018.07

  • 朝または夕方の12週間の運動が身体組成および代謝に及ぼす影響

    金 鉉基, 小西 真幸, 田端 宏樹, 中村 宣博, 高橋 将記, 柴田 重信, 坂本 静男

    第72回日本体力医学会大会 

    Presentation date: 2017.09

  • 肥満者の潜水徐脈反応は運動トレーニングにより変化するのか?

    小西 真幸, 金 鉉基, 田端 宏樹, 中村 宣博, 坂本 静男

    第72回日本体力医学会大会 

    Presentation date: 2017.09

  • 最大運動後の眼底血流の低下は飲料摂取によって早期回復する

    池村 司, 中村 宣博, 矢田 光一, 林 直亨, 鈴木 克彦

    第72回日本体力医学会大会 

    Presentation date: 2017.09

  • Effects of increasing central arterial stiffness on cerebral blood flow pulsatility in resistance-trained men.

    Nakamura N, Muraoka I

    22nd annual congress of the european college of sport science in MetropolisRuhr/GER 

    Presentation date: 2017.07

  • 異なる先行運動がその後の持久運動時の脂質代謝に及ぼす影響

    藤井 亮輔, 中村宣博, 河村 拓史, 池村 司, 小西 真幸, 鈴木 克彦, 坂本 静男, 村岡 功

    第71回日本体力医学会大会 

    Presentation date: 2016.09

  • 一過性の高強度レジスタンス運動が脳血流量および動脈スティフネスに及ぼす影響

    中村 宣博, 池村司, 村岡功

    第71回日本体力医学会大会 

    Presentation date: 2016.09

  • 安静時における呼気アセトン排出と脂肪酸化量の関係

    藤井 亮輔, 中村 宣博, 池村 司, 村岡 功

    第70回日本体力医学会大会 

    Presentation date: 2015.09

  • 異なる運動強度における運動中の脂肪酸化および呼気アセトン排出の応答

    中村 宣博, 藤井 亮輔, 池村 司, 村岡 功

    第70回日本体力医学会大会 

    Presentation date: 2015.09

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Research Projects

  • 中枢性血圧調節に着目したモーニングサージのメカニズムの解明

    日本学術振興会  科学研究費助成事業 若手研究

    Project Year :

    2022.04
    -
    2025.03
     

    中村 宣博

  • Does resistance training blunt arterial baroreflex sensitivity

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2019.08
    -
    2022.03
     

    Nakamura Nobuhiro

     View Summary

    The present study showed that the resistance-trained group demonstrated a higher arterial stiffness, lower arterial compliance, and lower arterial baroreflex sensitivity compared with the control group. In addition, arterial baroreflex sensitivity was inversely and positively correlated with the arterial stiffness and compliance, respectively (Fig 2A and B). These findings suggest that greater arterial stiffness with resistance training may blunt arterial baroreflex sensitivity.

Misc

  • アトピー性皮膚炎患者の病態と日常身体活動量との関係

    枝 伸彦, 辻 雄介, 斎藤 辰哉, 竹村 藍, 中村 宣博, 稲井 勇仁, 岩田 理沙, 赤間 高雄

    日本臨床スポーツ医学会誌   29 ( 4 ) S206 - S206  2021.10

  • Cardiorespiratory Fitness and Prevalence of Lifestyle-related Diseases In Japanese Men And Women: WASEDA'S Health Study

    Susumu S. Sawada, Ryoko Kawakami, Kumpei Tanisawa, Hiroki Tabata, Nobuhiro Nakamura, Kim Hyeon-Ki, Masayuki Konishi, Tomoko Ito, Chiyoko Usui, Taishi Midorikawa, Mitsuru Higuchi, Katsuhiko Suzuki, Suguru Torii, Lee I-Min, Steven N. Blair, Isao Muraoka, Kaori Ishii, Koichiro Oka, Shizuo Sakamoto

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   51 ( 6 ) 218 - 219  2019.06

    Research paper, summary (international conference)  

    DOI

  • Parasympathetic Nervous Regulation and Prevalence of Lifestyle-related Diseases In Japanese: Waseda's Health Study

    Masayuki Konishi, Susumu S. Sawada, Ryoko Kawakami, Kumpei Tanisawa, Hiroki Tabata, Nobuhiro Nakamura, Hyeon-Ki Kim, Tomoko Ito, Mitsuru Higuchi, Katsuhiko Suzuki, Suguru Torii, I-Min Lee, Steven N. Blair, Koichiro Oka, Shizuo Sakamoto

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   51 ( 6 ) 216 - 216  2019.06

    Research paper, summary (international conference)  

    DOI

  • 異なる運動強度における運動中の脂肪酸化および呼気アセトン排出の応答

    中村宣博, 藤井亮輔, 池村司, 村岡功

    体力科学   64 ( 6 ) 606  2015.12

    Research paper, summary (national, other academic conference)  

    J-GLOBAL

  • 安静時における呼気アセトン排出と脂肪酸化量の関係

    藤井亮輔, 中村宣博, 池村司, 村岡功

    体力科学   64 ( 6 ) 605  2015.12

    Research paper, summary (national, other academic conference)  

    J-GLOBAL

 

Syllabus

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Sub-affiliation

  • Affiliated organization   Global Education Center

Internal Special Research Projects

  • 筋力トレーニングに伴う動脈硬化が動脈圧受容器感受性に及ぼす影響

    2022  

     View Summary

     動脈圧受容器反射は正常血圧を維持するために最も重要な調節因子であり、この反射の感受性が鈍化することで心血管疾患リスクの増大につながる。動脈圧受容器は血管の伸展を感知し、その程度に応じて血圧を調節している。近年では、動脈が伸展しやすい状態、すなわち動脈硬化度が低い者ほど動脈圧受容器感受性が高いことが分かっている。健康の保持増進として期待されている筋力トレーニングが動脈硬化を引き起こすことが明らかになっている。つまり、筋力トレーニングが動脈圧受容器反射感受性を鈍化させる可能性が考えられる。そこで、本研究は、筋力トレーニングに伴う動脈硬化が動脈圧受容器反射感受性に及ぼす影響を明らかにすることを目的とした。本目的を達成するため、筋力トレーニング介入研究を計画した。 本研究では、筋力トレーニング習慣の無い者に対して、12週間の筋力トレーニング介入を行った。現状、ランダム化後、コントロール群6名および筋力トレーニング群4名実施している。今後は、対象者数を増やし、本研究を継続していく予定である。