Updated on 2022/05/26

写真a

 
NAKAMURA, Nobuhiro
 
Affiliation
Faculty of Sport Sciences, School of Sport and Sciences
Job title
Assistant Professor(without tenure)

Education

  • 2016.04
    -
    2019.03

    Waseda University   Graduate School of Sport Sciences  

Degree

  • 早稲田大学   博士(スポーツ科学)

Research Experience

  • 2021.04
    -
    Now

    Waseda University   Faculty of Sport Sciences

  • 2021.04
    -
    2022.03

    Yokohama College of Commerce   Yokohama College of Commerce

  • 2019.04
    -
    2021.03

    Yokohama College of Commerce   Yokohama College of Commerce Department of Management Information

Professional Memberships

  •  
     
     

    European College of Sport Science

  •  
     
     

    THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE

 

Research Areas

  • Nutrition science and health science

  • Clinical pharmacy

  • Physiology

Research Interests

  • 動脈圧受容器

  • 運動昇圧反射

  • トレーニング

  • 動脈硬化

  • 循環器

  • 生理学

  • 運動生理学

▼display all

Papers

  • Changes in the skin characteristics associated with dehydration and rehydration.

    Nobuhiko Eda, Nobuhiro Nakamura, Yuto Inai, Ziyue Sun, Ryota Sone, Koichi Watanabe, Takao Akama

    European journal of sport science     1 - 20  2022.02  [Refereed]  [International journal]

     View Summary

    AbstractThe present study aimed to test the hypothesis that changes in the dermal tissue dielectric constant (TDC) and biomechanical properties of the skin would be correlated with the indicators related to dehydration. Ten healthy adult men were enrolled in three trials: no fluid intake (DEH), ad libitum fluid intake (AL-HYD), and programmed fluid intake (P-HYD) after exercise in a randomized crossover design. The participants performed a pedaling exercise at 60% heart rate reserve until 2% body mass loss. At 120 min after exercise, an incremental exercise test was carried out. Aerobic capacity, body composition, TDC, biomechanical properties of the skin (pliability, viscoelasticity, and total recovery), and indicators related to dehydration in the serum and urine were measured before and 120 min after exercise. Higher values of the pliability and viscoelasticity, and lower value of the total recovery on the hand were demonstrated in the P-HYD trial compared to the DEH trial (all P < 0.05). Changes in the TDC were significantly correlated with changes in body mass (P < 0.05), total body water (P < 0.05), serum osmolarity (P < 0.05), and hematocrit (P < 0.01). Changes in the biomechanical properties of the hand were significantly correlated with changes in body mass, hematocrit, and urine specific gravity (all P < 0.05). The present study showed that the changes in skin characteristics correlated with the body water and dehydration-associated indicators in the serum and urine, thus suggesting that skin characteristics may be useful in the assessment of dehydration.

    DOI PubMed

  • Impact of acute dynamic exercise on vascular stiffness in the retinal arteriole in healthy subjects.

    Tsukasa Ikemura, Nobuhiro Nakamura, Naoyuki Hayashi

    Journal of applied physiology (Bethesda, Md. : 1985)   132 ( 2 ) 459 - 468  2022.02  [Refereed]  [International journal]

     View Summary

    Acute exercise can improve vascular stiffness in the conduit artery, but its effect on the retinal arterioles is unknown. The present study investigated the effects of acute dynamic exercise on retinal vascular stiffness. In experiment 1, we measured the cardio-ankle vascular index (CAVI), carotid artery intima-media thickness (carotid IMT), and retinal blood velocity by laser speckle flowgraphy in 28 healthy old and 28 young men (69 ± 3 and 23 ± 3 yr, respectively). Pulse waveform variables, which were used as an index of retinal vascular stiffness, were assessed by retinal blood flow velocity profile analysis. In experiment 2, 18 healthy old and 18 young men (69 ± 3 and 23 ± 3 yr, respectively) underwent assessment of pulse waveform variables after a 30-min bout of moderate cycling exercise at an intensity of 60% heart rate reserve. There was a significant difference in the baseline pulse waveform variables between the old and young groups. Pulse waveform variables in the retinal arteriole did not significantly change after acute dynamic exercise, whereas CAVI significantly decreased. These findings suggest that retinal vascular stiffness does not change by acute exercise. The effect of exercise on vascular stiffness in the retinal arterioles might be different from that in the conduit artery.NEW & NOTEWORTHY Acute dynamic exercise is well known to improve vascular stiffness in the conduit artery while its effect on the retinal arterioles has been unknown. This study showed that an acute dynamic exercise does not change vascular stiffness in the retinal arteriole in healthy humans. Different responses to acute dynamic exercise in vascular stiffness in retinal arterioles and conduit arteries are suggested.

    DOI PubMed

  • Muscle stiffening is associated with muscle mechanoreflex-mediated cardioacceleration

    Nobuhiro Nakamura, Naoki Ikeda, Peng Heng, Isao Muraoka

    European Journal of Applied Physiology   122   781 - 790  2022.01  [Refereed]

    DOI

  • Effects of changes in large arterial compliance and small arterial buffer function with resistance training on cerebral blood flow pulsatility

    Nobuhiro Nakamura, Takafumi Kubo, Isao Muraoka

    GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE   180 ( 12 ) 805 - 814  2021.12

     View Summary

    BACKGROUND: Cerebral blood flow (CBF) pulsatility is dampened by large and small arterial buffer functions. Resistance training (RT) improved small arterial buffer function regardless of impaired large arterial compliance. This response to small arterial buffer function with RT may be compensatory adaptation to impaired large arterial compliance for protecting end-organs such as the brain from excessive pulsatile stresses. This study aimed to investigate the effects of changes in large arterial compliance and small arterial buffer functions with RT on CBF pulsatility.METHODS: Twenty healthy men were assigned to either the RT group (N.=10) or the control (CON) group (N.=10). Subjects in the RT group exercised three times/week for 8 weeks. Arterial compliance of common carotid artery was measured as an index of large arterial compliance. Dampening factor (DF) in the cerebral artery and pulsatility index (PI) in the middle cerebral artery (MCA) were used to evaluate small arterial buffer function and CBF pulsatility, respectively.RESULTS: In the RT group, arterial compliance significantly decreased (P<0.05) and DF in the cerebral artery signifi-cantly increased (P<0.05) after intervention compared to baseline. However, there was no change in PI in MCA in both groups. A negative correlation was found between Delta arterial compliance and Delta DF in the cerebral artery (r=-0.671, P<0.05).CONCLUSIONS: These results may suggest that the response of small arteries to RT is a compensatory adaptation to impaired large arterial compliance for protecting end organs from excessive pulsatile stresses.

    DOI

  • Effects of Greater Central Arterial Stiffness on Cardiovagal Baroreflex Sensitivity in Resistance-Trained Men

    Nobuhiro Nakamura, Isao Muraoka

    Sports Medicine - Open   7 ( 1 )  2021.12  [Refereed]

     View Summary

    <title>Abstract</title><sec>
    <title>Background</title>
    Compared with age-matched untrained men, resistance-trained men who have undergone long duration training (&gt; 2 years) at a high frequency (&gt; 5 days/week) may be lower cardiovagal baroreflex sensitivity (BRS) because of central arterial stiffening. Therefore, the purpose of this study was to examine the effect of greater central arterial stiffness in resistance-trained men on cardiovagal BRS in a cross-sectional study to compare resistance-trained men with age-matched untrained men.


    </sec><sec>
    <title>Methods</title>
    This cross-sectional study included resistance-trained men (<italic>n</italic> = 20; age: 22 ± 3; body mass index: 26.7 ± 2.2) and age-matched untrained men (control group: <italic>n</italic> = 20; age: 25 ± 2; body mass index: 23.7 ± 2.4). The β-stiffness index and arterial compliance were assessed at the right carotid artery using a combination of a brightness mode ultrasonography system for the carotid artery diameter and applanation tonometry for the carotid blood pressure. And, the cardiovagal BRS was estimated by the slope of the R–R interval and systolic blood pressure during Phase II and IV of Valsalva maneuver (VM). The participants maintained an expiratory mouth pressure of 40 mmHg for 15 s in the supine position.


    </sec><sec>
    <title>Results</title>
    The β-Stiffness index was significantly higher in the resistance-trained group than in the control group (5.9 ± 1.4 vs. 4.4 ± 1.0 a.u., <italic>P</italic> &lt; 0.01). In contrast, the resistance-trained group had significantly lower arterial compliance (0.15 ± 0.05 vs. 0.20 ± 0.04 mm2/mmHg, <italic>P</italic> &lt; 0.01) and cardiovagal BRS during Phase IV of VM (9.0 ± 2.5 vs. 12.9 ± 5.4 ms/mmHg, <italic>P</italic> &lt; 0.01) than the control group and. Moreover, cardiovagal BRS during Phase IV of VM was inversely and positively correlated with the β-stiffness index (<italic>r</italic> = − 0.59, <italic>P</italic> &lt; 0.01) and arterial compliance (<italic>r</italic> = 0.64, <italic>P</italic> &lt; 0.01), respectively.


    </sec><sec>
    <title>Conclusion</title>
    Resistance-trained group had greater central arterial stiffness and lower cardiovagal BRS Phase IV compared with control group. Moreover, the central arterial stiffening was related to cardiovagal BRS Phase IV. These results suggest that greater central arterial stiffness in resistance-trained men may be associated with lower cardiovagal BRS.


    <italic>Trial Registration</italic> University hospital Medical Information Network (UMIN) in Japan, UMIN000038116. Registered on September 27, 2019.


    </sec>

    DOI

  • The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males.

    Takaki Tominaga, Tsukasa Ikemura, Koichi Yada, Kazue Kanda, Kaoru Sugama, Sihui Ma, Wonjun Choi, Mayu Araya, Jiapeng Huang, Nobuhiro Nakamura, Katsuhiko Suzuki

    Antioxidants (Basel, Switzerland)   10 ( 6 )  2021.05  [Refereed]  [International journal]

     View Summary

    Strenuous exercise induces organ damage, inflammation and oxidative stress. To prevent exercise-induced organ damage, inflammation and oxidative stress, rehydrating may be an effective strategy. In the present study, we aimed to examine whether beverage intake after exhaustive exercise to recover from dehydration prevents such disorders. Thirteen male volunteers performed incremental cycling exercise until exhaustion. Immediately after exercise, the subjects drank an electrolyte containing water (rehydrate trial: REH) or did not drink any beverage (control trial: CON). Blood samples were collected before (Pre), immediately (Post), 1 h and 2 h after exercise. Urine samples were also collected before (Pre) and 2 h after exercise. We measured biomarkers of organ damage, inflammation and oxidative stress in blood and urine. Biomarkers of muscle, renal and intestinal damage and inflammation increased in the blood and urine after exercise. However, changes in biomarkers of organ damage and inflammation did not differ between trials (p > 0.05). The biomarker of oxidative stress, thiobarbituric acid reactive substances (TBARS), in plasma, showed different changes between trials (p = 0.027). One hour after exercise, plasma TBARS concentration in REH had a higher trend than that in CON (p = 0.052), but there were no significant differences between Pre and the other time points in each trial. These results suggest that beverage intake after exercise does not attenuate exercise-induced organ damage, inflammation or oxidative stress in healthy males. However, rehydration restores exercise-induced oxidative stress more quickly.

    DOI PubMed

  • Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA'S Health Study.

    Takuji Kawamura, Kumpei Tanisawa, Ryoko Kawakami, Chiyoko Usui, Tomoko Ito, Hiroki Tabata, Nobuhiro Nakamura, Sayaka Kurosawa, Wonjun Choi, Sihui Ma, Zsolt Radak, Susumu S Sawada, Katsuhiko Suzuki, Kaori Ishii, Shizuo Sakamoto, Koichiro Oka, Mitsuru Higuchi, Isao Muraoka

    Oxidative medicine and cellular longevity   2021   5566880 - 5566880  2021  [Refereed]  [International journal]

     View Summary

    Previous studies have not investigated the determinants of resting oxidative stress, including physical fitness, as it relates to redox regulation. The present study therefore was aimed at identifying lifestyle and biological factors that determine resting oxidative stress, including objectively measured physical fitness. In 873 middle-aged and elderly men and women, age and anthropometric parameters, lifestyle-related parameters, medication and supplementation status, physical fitness, biochemical parameters, and nutritional intake status, as well as three plasma oxidative stress markers: protein carbonyl (PC), F2-isoprostane (F2-IsoP), and thiobarbituric acid reactive substances (TBARS), were surveyed and measured. The determinants of PC, F2-IsoP, and TBARS in all participants were investigated using stepwise multiple regression analysis. In PC, age (β = -0.11, P = 0.002), leg extension power (β = -0.12, P = 0.008), BMI (β = 0.12, P = 0.004), and HDL-C (β = 0.08, P = 0.040) were included in the regression model (adjusted R 2 = 0.018). In the F2-IsoP, smoking status (β = 0.07, P = 0.060), BMI (β = 0.07, P = 0.054), and HbA1c (β = -0.06, P = 0.089) were included in the regression model (adjusted R 2 = 0.006). In TBARS, glucose (β = 0.18, P < 0.001), CRF (β = 0.16, P < 0.001), age (β = 0.15, P < 0.001), TG (β = 0.11, P = 0.001), antioxidant supplementation (β = 0.10, P = 0.002), and HbA1c (β = -0.13, P = 0.004) were included in the regression model (adjusted R 2 = 0.071). In conclusion, the present study showed that age, anthropometric index, lifestyle-related parameters, medication and supplementation status, objectively measured physical fitness, biochemical parameters, and nutritional intake status explain less than 10% of oxidative stress at rest.

    DOI PubMed

  • Tape stripping method is useful for the quantification of antimicrobial peptides on the human skin surface including the stratum corneum.

    Shigeyuki Ono, Nobuhiko Eda, Takuya Mori, Atsuko Otsuka, Nobuhiro Nakamura, Yuto Inai, Noriyasu Ota, Takao Akama

    Scientific reports   10 ( 1 ) 15259 - 15259  2020.09  [International journal]

     View Summary

    Antimicrobial peptides (AMPs) play an important role in innate immunity in human skin. It is known that AMPs mainly function in the stratum corneum. Therefore, AMP concentrations in the stratum corneum need to be precisely measured to clarify functional and physiological importance of AMPs in cutaneous defence. Tape stripping (TS) is a well-established method by which components in the stratum corneum can be collected. However, the usefulness of the TS method for measuring AMP concentration in human skin remains unclear. Therefore, we compared it with another popular method, skin rinsing, which had been established as a method for measuring AMP concentration in human skin. When investigated on healthy medial forearm using RNase 7, which is one of the typical AMPs, as an index, there was a significant positive correlation between RNase 7 concentrations measured by the TS method at adjacent forearm sites, demonstrating the reproducibility of the TS method. Next, a significant positive correlation was detected in RNase 7 concentrations measured using the TS and the skin rinsing method, indicating that the TS method is comparable to the skin rinsing method. Thus, we speculate that the TS method is useful for measuring AMP concentration in human skin.

    DOI PubMed

  • Influence of different preceding exercises on fat metabolism during subsequent endurance exercise

    Ryosuke Fujii, Nobuhiro Nakamura, Takuji Kawamura, Tsukasa Ikemura, Masayuki Konishi, Katsuhiko Suzuki, Shizuo Sakamoto, Isao Muraoka

    GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE   179 ( 6 ) 393 - 403  2020.06  [Refereed]

     View Summary

    BACKGROUND: Preceding exercise enhances fat metabolism during subsequent endurance exercise. However, it is unknown which type of exercise most enhances fat metabolism during subsequent exercise. The aim of this study was to examine the influence of preceding resistance or endurance exercise on fat metabolism during subsequent endurance exercise and to compare the effect with that without a preceding exercise.METHODS: Nine male subjects performed the following trials: 1) endurance exercise (E trial), 2) endurance exercise preceded by resistance exercise (R+E trial), and 3) endurance exercise preceded by endurance exercise (E+E trial). There was a 20-min break after the preceding exercise. Subsequent endurance exercise was performed on a cycle ergometer at 80% of the individual ventilatory threshold. Blood and exhaled gas were analyzed respectively.RESULTS: The R+E and E+E trials showed a significantly lower respiratory exchange ratio (RER) and a higher amount of fat oxidation during endurance exercise than those in the E trial (P<0.05). Furthermore, the E+E trial showed a significantly lower RER (0.86 +/- 0.03 vs. 0.84 +/- 0.02) and a significantly higher amount of fat oxidation (0.38 +/- 0.05 g/min vs. 0.44 +/- 0.08 g/min) than those in the R+E trial.CONCLUSIONS: This study suggested that fat oxidation during subsequent endurance exercise was enhanced when a preceding exercise was performed and that endurance exercise as a preceding exercise enhanced fat oxidation more than resistance exercise did.

    DOI

  • Acute effect of increased arterial stiffness with high-intensity resistance exercise on cerebral blood flow

    Nobuhiro Nakamura, Tsukasa Ikemura, Isao Muraoka

    GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE   178 ( 4 ) 195 - 202  2019.04  [Refereed]

     View Summary

    BACKGROUND: Increased arterial stiffness decreases cerebral blood flow (CBF), which plays a vital role in the maintenance of life and cognitive function. Previous studies have shown that high-intensity resistance exercise (HRE) increases arterial stiffness. HRE may decrease cerebral blood flow. However, the effect of increased arterial stiffness associated with HRE on CBF is not fully elucidated. Therefore, this study aimed to investigate the effect of increased arterial stiffness with HRE on CBF.METHODS: Study participants included 8 healthy young men. All subjects performed three exercise trials in a crossover design: HRE, low-intensity resistance exercise (LRE), and aerobic exercise (AE). beta-stiffness index was measured as an index of arterial stiffness, and global cerebral blood flow was measured as an index of cerebral blood flow. These were measured at rest, immediately after exercise, and 10 minutes post-exercise.RESULTS: Global cerebral blood flow was significantly increased immediately after and 10 minutes after AE. In contrast, a significant decrease of global cerebral blood flow was observed immediately after and 10 minutes following HRE. However, no changes were observed in LRE. With HRE, beta-stiffness index was significantly increased immediately after and 10 minutes post-exercise. In contrast, no differences were observed in arterial stiffness associated with aerobic exercise and LRE. A negative correlation was found between global cerebral blood flow and arterial stiffness at rest and immediately after and 10 minutes post-exercise.CONCLUSIONS: These results suggested that HRE increased arterial stiffness and decreased cerebral blood flow.

    DOI

  • Effect of accommodating elastic bands on mechanical power output during back squats.

    Kubo T, Hirayama K, Nakamura N, Higuchi M

    Sports (Basel)   6 ( 4 )  2018.11  [Refereed]  [International journal]

     View Summary

    The aim of this study was to investigate whether accommodating elastic bands with barbell back squats (BSQ) increase muscular force during the deceleration subphase. Ten healthy men (mean ± standard deviation: Age: 23 ± 2 years; height: 170.5 ± 3.7 cm; mass: 66.7 ± 5.4 kg; and BSQ one repetition maximum (RM): 105 ± 23.1 kg; BSQ 1RM/body mass: 1.6 ± 0.3) were recruited for this study. The subjects performed band-resisted parallel BSQ (accommodating elastic bands each sides of barbell) with five band conditions in random order. The duration of the deceleration subphase, mean mechanical power, and the force and velocity during the acceleration and deceleration subphases were calculated. BSQ with elastic bands elicited greater mechanical power output, velocity, and force during the deceleration subphase, in contrast to that elicited with traditional free weight (p < 0.05). BSQ with elastic bands also elicited greater mechanical power output and velocity during the acceleration subphase. However, the force output during the acceleration subphase using an elastic band was lesser than that using a traditional free weight (p < 0.05). This study suggests that BSQ with elastic band elicit greater power output during the acceleration and deceleration subphases.

    DOI PubMed

  • Influence of different loads on force-time characteristics during back squats

    Kubo T, Hirayama K, Nakamura N, Higuchi M

    Journal of Sports Science and Medicine   17 ( 4 ) 617 - 622  2018.11  [Refereed]  [International journal]

     View Summary

    The deceleration sub-phase during the back squat (BSQ) makes it difficult to stimulate the muscles throughout the full range of motion, and it has only been reported for one load during BSQ. The purpose of this study was to investigate whether a deceleration sub-phase occurs during BSQ with different loads and to assess the influence of load on the deceleration sub-phase duration and negative impulse during the deceleration sub-phase. Sixteen healthy men (mean ± standard deviation: age: 25 ± 3 years; height: 1.73 ± 0.07 m; mass: 83.2 ± 16.1 kg; BSQ one repetition maximum (1RM): 163.8 ± 36.6 kg; BSQ 1RM/body weight: 2.0 ± 0.4) who had performed resistance training for at least 1 year were recruited for this study. The subjects performed parallel BSQ with 0%, 12%, 27%, 42%, 56%, 71%, and 85% of each 1RM on a force plate in a random order. The deceleration sub-phase duration and negative impulse during the deceleration sub-phase were calculated from force-time data. The absolute durations of the deceleration sub-phase were not significantly different according to load except for 27% 1RM and 85% 1RM (p = 0.01). However, as the load increased from 12 to 85% 1RM, the relative duration of the deceleration sub-phase decreased (p < 0.05). The negative impulse during the deceleration sub-phase also increased from 0 to 42% 1RM (p < 0.05). A deceleration sub-phase occurs regardless of the load (0%-85% 1RM), and a large portion of the deceleration sub-phase occupied the concentric phase, with low-moderate loads, and a large amount of negative impulse occurred during the short deceleration sub-phase with a high load.

    PubMed

  • Breath acetone excretion during graded exercise and moderate-intensity aerobic exercise

    中村宣博, 藤井亮輔, 池村司, 村岡功

    日本運動生理学雑誌   25 ( 2 ) 31 - 40  2018.11  [Refereed]

    J-GLOBAL

  • Resistance training augments cerebral blood flow pulsatility: cross-sectional study.

    Nakamura N, Muraoka I

    American Journal of Hypertension   31 ( 7 ) 811 - 817  2018.07  [Refereed]  [International journal]

     View Summary

    BACKGROUND: Increased central arterial stiffness and/or decreased compliance reduces buffer function and increases cerebral blood flow (CBF) pulsatility, which leads to increased cerebral microvascular damage, resulting in the augmentation of the risk of cerebrovascular diseases. Resistance-trained men showed higher central arterial stiffness and lower arterial compliance than age-matched, sedentary men. This study examined the effect of increased central arterial stiffness and/or decreased arterial compliance on CBF pulsatility. METHODS: The study participants included 31 young healthy men (15 resistance-trained men, aged 21 ± 1 years; and 16 controls, aged 23 ± 1 years). β-Stiffness index and arterial compliance were measured in the right carotid artery as index of central arterial stiffness and compliance, respectively. The pulsatility index (PI) was measured in the middle cerebral artery as index of CBF pulsatility. RESULTS: β-Stiffness index and PI were significantly higher in the resistance-trained group than in the control group (β-stiffness index: 5.3 ± 0.3 vs. 3.5 ± 0.3 a.u., P < 0.05, PI: 0.80 ± 0.02 vs. 0.70 ± 0.02, P < 0.05). The resistance-trained group showed significantly lower arterial compliance than the control group (0.16 ± 0.01 vs. 0.23 ± 0.01 mm2/mm Hg, P < 0.05). Positive and negative correlations were observed between β-stiffness index and PI (r = 0.39, P < 0.05), and between arterial compliance and PI (r = -0.59, P < 0.05), respectively. CONCLUSIONS: The resistance-trained group showed higher central arterial stiffness and PI and lower arterial compliance. Central arterial stiffness and arterial compliance were associated with PI. Increased arterial stiffness and decreased arterial compliance with resistance training impair buffer function, resulting in increased CBF pulsatility. CLINICAL TRIAL REGISTRATION: Trial Number UMIN000023816 URL: http://www.umin.ac.jp/icdr/index.html Official scientific title of the study: effect of increase arterial stiffness by resistance training on cerebral hemodynamic.

    DOI PubMed

  • Fluid intake restores retinal blood flow early after exhaustive exercise in healthy subjects.

    Tsukasa Ikemura, Katsuhiko Suzuki, Nobuhiro Nakamura, Koichi Yada, Naoyuki Hayashi

    European journal of applied physiology   118 ( 5 ) 1053 - 1061  2018.05  [Refereed]  [International journal]

     View Summary

    PURPOSE: It remains unclear whether rehydration restores retinal blood flow reduced by exhaustive exercise. We investigated the effect of fluid intake on retinal blood flow after exhaustive exercise. METHODS: Blood flow in the inferior (ITRA) and superior temporal retinal arterioles (STRA) was measured before and after incremental cycling exercise until exhaustion in 13 healthy males. After the exercise, the subjects rested without drinking (control condition: CON) or with drinking an electrolyte containing water (rehydrate condition: REH) and were followed up for a period of 120 min. To assess the hydration state, the body mass was measured, and venous blood samples were collected and plasma volume (PV) was calculated. RESULTS: Body mass decreased in CON after the trial [- 1.1 ± 0.1% (mean ± SE), p < 0.05]. PV was lower in CON than in REH during recovery. The ITRA and STRA blood flows decreased immediately after exercise from the resting baseline (ITRA; - 23 ± 4% in REH and - 30 ± 4% in CON, p < 0.05). The ITRA blood flow recovered baseline level at 15 min of recovery in REH (- 9 ± 3%, p = 0.5), but it remained reduced in CON (-14 ± 3%, p < 0.05). The STRA blood flow was higher in REH than in CON at 15 min (2 ± 3 vs. - 5 ± 3%, p < 0.05). CONCLUSIONS: The results of this study suggest that the reduction in retinal blood flow induced by exhaustive exercise can be recovered early by rehydration.

    DOI PubMed

  • Relationship Between Acetone Excretion in Exhaled Breath and Fat Oxidation During Rest

    藤井亮輔, 中村宣博, 池村司, 村岡功

    日本運動生理学雑誌   24 ( 1 ) 1 - 6  2017.03  [Refereed]

    J-GLOBAL

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Misc

  • Parasympathetic Nervous Regulation and Prevalence of Lifestyle-related Diseases In Japanese: Waseda's Health Study

    Masayuki Konishi, Susumu S. Sawada, Ryoko Kawakami, Kumpei Tanisawa, Hiroki Tabata, Nobuhiro Nakamura, Hyeon-Ki Kim, Tomoko Ito, Mitsuru Higuchi, Katsuhiko Suzuki, Suguru Torii, I-Min Lee, Steven N. Blair, Koichiro Oka, Shizuo Sakamoto

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   51 ( 6 ) 216 - 216  2019.06

    Research paper, summary (international conference)  

    DOI

  • 異なる運動強度における運動中の脂肪酸化および呼気アセトン排出の応答

    中村宣博, 藤井亮輔, 池村司, 村岡功

    体力科学   64 ( 6 ) 606  2015.12

    Research paper, summary (national, other academic conference)  

    J-GLOBAL

  • 安静時における呼気アセトン排出と脂肪酸化量の関係

    藤井亮輔, 中村宣博, 池村司, 村岡功

    体力科学   64 ( 6 ) 605  2015.12

    Research paper, summary (national, other academic conference)  

    J-GLOBAL

Awards

  • 濱野吉生記念褒賞

    2019.03   早稲田大学スポーツ科学研究科  

    Winner: 中村 宣博

Research Projects

  • 中枢性血圧調節に着目したモーニングサージのメカニズムの解明

    日本学術振興会  科学研究費助成事業 若手研究

    Project Year :

    2022.04
    -
    2025.03
     

    中村 宣博

  • 筋力トレーニングに伴う動脈硬化は動脈圧受容器の感受性を鈍化させてしまうのか?

    日本学術振興会  科学研究費助成事業 研究活動スタート支援

    Project Year :

    2019.08
    -
    2022.03
     

    中村 宣博

     View Summary

    動脈圧受容器反射は短期的な血圧変動に対して血圧の恒常性を維持する最も重要な調節機構である。この反射の感受性は加齢や高血圧によって鈍化することが報告されている。また、動脈圧受容器反射感受性の鈍化が重篤な不整脈のリスク増大につながることや急性心臓死の前兆となることが報告されている。動脈圧受容器反射は大動脈洞および頸動脈洞が動脈の伸展を感知し、その程度に応じて血圧を調節しているため、大動脈や頸動脈といった動脈の硬化度が動脈圧受容器反射の感受性の低下と関連することが報告されている。
    筋力トレーニングは日常生活動作(ADL)の改善ひいては健康寿命の延伸に寄与することが期待されており、広く推奨されている。一方、筋力トレーニングは動脈硬化を促進させることが報告されている。また、いくつかの研究では、習慣的に筋力トレーニングを実施している者(鍛錬者)は同年代の非鍛錬者よりも動脈硬化度が高いことが示されている。さらに、メタ解析においても同様の結果が得られている。しかし、この動脈硬化がどのような弊害を有しているかについてほとんど検討されていないのが現状である。
    先行研究では、習慣的な運動による動脈の硬化度の変化が動脈圧受容器反射の感受性を変化させることが示唆されている。以上のことから、筋力トレーニングに伴う中心動脈スティフネスの増加およびコンプライアンスの低下は動脈圧受容器反射の感受性を鈍化させる可能性があると思われる。そこで、本研究課題は筋力トレーニングに伴う動脈硬化が動脈圧受容器反射の感受性に及ぼす影響を検討することとした。

Presentations

  • Parasympathetic nervous regulation and prevalence of lifestyle-related diseases in Japanese: WASEDA'S Health Study

    Masayuki Konishi, Susumu S. Sawada, Ryoko Kawakami, Kumpei Tanisawa, Hiroki Tabata, Nobuhiro Nakamura, Hyeon-Ki Kim, Tomoko Ito, Mitsuru Higuchi, Katsuhiko Suzuki, Suguru Torii, I-Min Lee F, Steven N. Blair, Koichiro Oka, Shizuo Sakamoto

    66th Annual Meeting of the American College of Sports Medicine 

    Presentation date: 2019.05

  • Cardiorespiratory fitness and prevalence of lifestyle-related diseases in Japanese men and womenWASEDA’S Health Study

    Susumu S. Sawada, Ryoko Kawakami, Kumpei Tanisawa, Hiroki Tabata, Nobuhiro Nakamura, Hyeon-Ki Kim, Masayuki Konishi, Tomoko Ito, Chiyoko Usui, Taishi Midorikawa, Mitsuru Higuchi, Katsuhiko Suzuki, Suguru Torii, I-Min Lee, Steven N. Blair, Isao Muraoka, Kaori Ishii, Koichiro Oka, Shizuo Sakamoto

    66th Annual Meeting of the American College of Sports Medicine 

    Presentation date: 2019.05

  • 中高齢男女における潜水徐脈および運動後心拍回復と生活習慣病有病率の関係:WASEDA'S Health Study

    小西 真幸, 澤田 享, 川上 諒子, 谷澤 薫平, 田端 宏樹, 中村 宣博, 金 鉉基, 伊藤 智子, 樋口 満, 鈴木 克彦, 鳥居 俊, 村岡 功, 石井 香織, 岡 浩一朗, 坂本 静男

    第6回介護予防・健康 づくり学会大会 

    Presentation date: 2018.11

  • 日本人中高齢者における全身持久力と生活習慣病有病率の関係-WASEDA'S Health Study-

    澤田 享, 川上 諒子, 谷澤 薫平, 田端 宏樹, 中村 宣博, 金 鉉基, 小西 真幸, 伊藤 智子, 薄井 澄誉子, 緑川 泰史, 樋口 満, 鈴木 克 彦, 鳥居 俊, 村岡 功, 石井 香織, 岡 浩一朗, 坂本 静男

    第6回介護予防・健康 づくり学会大会 

    Presentation date: 2018.11

  • 腸内水素ガス産生乳飲料の摂取が高強度運動後の酸化ストレス応答に及ぼす影響

    枝 伸彦, 中村 宣博, 曽根 良太, 松本 光晴, 赤間 高雄

    第73回日 本体力医学会大会 

    Presentation date: 2018.09

  • 朝または夕の12週間の持久性運動が炎症・抗炎症サイトカインに及ぼす影響

    金 鉉基, 小西 真幸, 田端 宏樹, 中村 宣博, 髙橋 将記, 柴田 重信, 坂本 静男

    第 73 回日本体力医学会大会 

    Presentation date: 2018.09

  • レジスタンストレーニングが中心および末梢動脈の血流拍動性緩衝能に及ぼす影響

    中村 宣博, 久保 孝史, 村岡 功

    第73回日本体力医学会大会 

    Presentation date: 2018.09

  • Effect of increased central arterial stiffness with resistance training on cerebral blood flow pulsatility.

    Nakamura N, Kubo T, Muraoka I

    23rd annual congress of the european college of sport science in Dublin/Ireland 

    Presentation date: 2018.07

  • 朝または夕方の12週間の運動が身体組成および代謝に及ぼす影響

    金 鉉基, 小西 真幸, 田端 宏樹, 中村 宣博, 高橋 将記, 柴田 重信, 坂本 静男

    第72回日本体力医学会大会 

    Presentation date: 2017.09

  • 肥満者の潜水徐脈反応は運動トレーニングにより変化するのか?

    小西 真幸, 金 鉉基, 田端 宏樹, 中村 宣博, 坂本 静男

    第72回日本体力医学会大会 

    Presentation date: 2017.09

  • 最大運動後の眼底血流の低下は飲料摂取によって早期回復する

    池村 司, 中村 宣博, 矢田 光一, 林 直亨, 鈴木 克彦

    第72回日本体力医学会大会 

    Presentation date: 2017.09

  • Effects of increasing central arterial stiffness on cerebral blood flow pulsatility in resistance-trained men.

    Nakamura N, Muraoka I

    22nd annual congress of the european college of sport science in MetropolisRuhr/GER 

    Presentation date: 2017.07

  • 異なる先行運動がその後の持久運動時の脂質代謝に及ぼす影響

    藤井 亮輔, 中村宣博, 河村 拓史, 池村 司, 小西 真幸, 鈴木 克彦, 坂本 静男, 村岡 功

    第71回日本体力医学会大会 

    Presentation date: 2016.09

  • 一過性の高強度レジスタンス運動が脳血流量および動脈スティフネスに及ぼす影響

    中村 宣博, 池村司, 村岡功

    第71回日本体力医学会大会 

    Presentation date: 2016.09

  • 安静時における呼気アセトン排出と脂肪酸化量の関係

    藤井 亮輔, 中村 宣博, 池村 司, 村岡 功

    第70回日本体力医学会大会 

    Presentation date: 2015.09

  • 異なる運動強度における運動中の脂肪酸化および呼気アセトン排出の応答

    中村 宣博, 藤井 亮輔, 池村 司, 村岡 功

    第70回日本体力医学会大会 

    Presentation date: 2015.09

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Syllabus