2022/12/02 更新

写真a

コウサキ ユタカ
神前 裕
Scopus 論文情報  
論文数: 0  Citation: 0  h-index: 9

Citation Countは当該年に発表した論文の被引用数

所属
文学学術院 文学部
職名
教授

学歴

  •  
    -
    2008年11月

    University of Cambridge,   Department of Experimental Psychology (PhD)  

学位

  • University of Cambridge   PhD

経歴

  • 2022年04月
    -
    継続中

    早稲田大学   文学部   教授

  • 2017年04月
    -
    2022年03月

    早稲田大学   文学部   准教授

  • 2015年12月
    -
    2017年03月

    慶應義塾大学   先導研究センター   特任助教

  • 2014年04月
    -
    2015年11月

    慶應義塾大学   先導研究センター   研究員

  • 2011年11月
    -
    2014年03月

    Cardiff University,   School of Psychology,   Research Associate

  • 2008年11月
    -
    2011年10月

    Durham University,   Department of Psychology,   Research Associate

▼全件表示

所属学協会

  •  
     
     

    日本神経科学学会

  •  
     
     

    日本動物心理学会

 

研究分野

  • 神経科学一般   行動神経科学

  • 神経科学一般   行動神経科学

  • 実験心理学   学習理論

研究キーワード

  • パヴロフ型条件づけ

  • 刺激間競合

  • 道具的条件づけ

  • 学習

  • 刺激-反応習慣

  • 前帯状皮質

  • 前頭前野

  • 線条体

  • 海馬

  • 社会行動

  • 複数記憶システム

  • 強化学習

  • 空間学習

  • 目的的行動

  • 行動神経科学

  • 連合学習理論

▼全件表示

論文

  • Measurement of the exploration–exploitation response of dogs through a concurrent visual discrimination task

    Kumi Shinoda, Yutaka Kosaki, Miho Nagasawa, Takefumi Kikusui

      199   104644 - 104644  2022年06月  [査読有り]

    DOI

    Scopus

  • Higher-Order Conditioning in the Spatial Domain

    Youcef Bouchekioua, Yutaka Kosaki, Shigeru Watanabe, Aaron P. Blaisdell

    Frontiers in Behavioral Neuroscience   15  2021年11月  [査読有り]

    DOI

    Scopus

  • Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions

    Steven L. Poulter, Yutaka Kosaki, David J. Sanderson, Anthony McGregor

    Brain and Neuroscience Advances   4   239821282097259 - 239821282097259  2020年11月  [査読有り]

    DOI

  • Spatial inference without a cognitive map: the role of higher‐order path integration

    Youcef Bouchekioua, Aaron P. Blaisdell, Yutaka Kosaki, Iku Tsutsui‐Kimura, Paul Craddock, Masaru Mimura, Shigeru Watanabe

    Biological Reviews    2020年09月  [査読有り]

    DOI

    Scopus

    5
    被引用数
    (Scopus)
  • En route to delineating hippocampal roles in spatial learning.

    Poulter, S, Austen, J. M, Kosaki, Y, Dachtler, J, Lever, C, McGregor, A

    Behavioural Brain Research   369 ( online first publication )  2019年  [査読有り]

  • The response strategy and the place strategy in a plus‐maze have different sensitivities to devaluation of expected outcome.

    Kosaki, Y, Pearce, J. M, McGregor, A

    Hippocampus   28 ( 7 ) 484 - 496  2018年07月  [査読有り]

    DOI

    Scopus

    11
    被引用数
    (Scopus)
  • Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

    Youcef Bouchekioua, Iku Tsutsui-Kimura, Hiromi Sano, Miwako Koizumi, Kenji F. Tanaka, Keitaro Yoshida, Yutaka Kosaki, Shigeru Watanabe, Masaru Mimura

    Neuroscience Research   132   53 - 57  2018年07月  [査読有り]

     概要を見る

    Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

    DOI

    Scopus

    12
    被引用数
    (Scopus)
  • Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits

    Akihiro Shimbo, Yutaka Kosaki, Isao Ito, Shigeru Watanabe

    BEHAVIOURAL BRAIN RESEARCH   336   156 - 165  2018年01月  [査読有り]

     概要を見る

    Left-right asymmetry is known to exist at several anatomical levels in the brain and recent studies have provided further evidence to show that it also exists at a molecular level in the hippocampal CA3-CA1 circuit. The distribution of N-methyl-o-aspartate (NMDA) receptor NR2B subunits in the apical and basal synapses of CA1 pyramidal neurons is asymmetrical if the input arrives from the left or right CA3 pyramidal neurons. In the present study, we examined the role of hippocampal asymmetry in cognitive function using beta 2-microglobulin knock-out (Pm KO) mice, which lack hippocampal asymmetry. We tested beta 2m KO mice in a series of spatial and non-spatial learning tasks and compared the performances of beta 2m KO and C57BL6/J wild-type (WT) mice. The beta 2m KO mice appeared normal in both spatial reference memory and spatial working memory tasks but they took more time than WT mice in learning the two non-spatial learning tasks (i.e., a differential reinforcement of lower rates of behavior (DRL) task and a straight runway task). The beta 2m KO mice also showed less precision in their response timing in the DRL task and showed weaker spontaneous recovery during extinction in the straight runway task. These results indicate that hippocampal asymmetry is important for certain characteristics of non spatial learning.

    DOI

    Scopus

    4
    被引用数
    (Scopus)
  • Impaired Pavlovian predictive learning between temporally phasic but not static events in autism-model strain mice

    Yutaka Kosaki, Shigeru Watanabe

    NEUROBIOLOGY OF LEARNING AND MEMORY   134   304 - 316  2016年10月  [査読有り]

     概要を見る

    Autism-spectrum disorder (ASD) is a multi-aspect developmental disorder characterised by various social and non-social behavioural abnormalities. Using BTBR T+ tf mouse strain (BTBR), a promising animal model displaying a number of behavioural and neural characteristics associated with ASD, we tested the hypothesis that at the core of various symptoms of ASD lies a fundamental deficit in predictive learning between events. In five experiments, we conducted a variety of Pavlovian conditioning tasks, some requiring the establishment of associations between temporally phasic events and others involving static events. BTBR mice were impaired in the acquisition of conditioned magazine approach responses with an appetitive unconditioned stimulus (US) (Experiment 1) and conditioned freezing with an electric shock US (Experiment 2). Both of these tasks had temporally phasic conditioned stimuli (CSs). Conversely, these mice showed normal acquisition of conditioned place preference (CPP), whether the US was a systemic injection of methamphetamine (Experiment 3A) or the presence of food (Experiment 3B). Experiment 4 showed normal acquisition of conditioned taste aversion (CTA) to a flavour-taste compound CS, although BTBR mice still exhibited an abnormal stimulus selection when learning for each element of the compound CS was assessed separately. Experiment 5 revealed a weaker latent inhibition of CTA in BTBR mice. The BTBR mouse's impaired predictive learning between phasic events and intact associations between static events are discussed in terms of dysfunctional contingency-based, but not contiguity based learning, which may accompany abnormal selective attention to relevant cues. We propose that such dysfunctional contingency learning mechanisms may underlie the development of various social and non-social symptoms of ASD. (C) 2016 Elsevier Inc. All rights reserved.

    DOI

    Scopus

    2
    被引用数
    (Scopus)
  • Conditioned Social Preference, But Not Place Preference, Produced by Intranasal Oxytocin in Female Mice

    Yutaka Kosaki, Shigeru Watanabe

    BEHAVIORAL NEUROSCIENCE   130 ( 2 ) 182 - 195  2016年04月  [査読有り]

     概要を見る

    Oxytocin (OT) has been implicated in a variety of mammalian reproductive and social behaviors, and the use of intranasal OT for clinical purposes is on the rise. However, basic actions of OT, including the rewarding or reinforcing properties of the drug, are currently not fully understood. In this study, the authors investigated whether intranasally administered OT has different reinforcing properties for social and nonsocial stimuli and whether such effects are variable between male and female subjects. Conditioned social preference (CSP) and conditioned place preference (CPP) paradigms were used to examine social and nonsocial reinforcing properties of OT. In CSP, the presence of a same-sex unfamiliar conspecific was repeatedly paired with intranasal OT, while a different conspecific was associated with saline. The reinforcing effect of OT was assessed in a postconditioning choice test under a drug-free condition. In CPP, the 2 conspecifics were replaced with nonsocial black and white compartments. The authors found that intranasal OT (12 mu g) in females supported the formation of CSP (Experiment 1) but not CPP (Experiment 3). Neither CSP (Experiment 2) nor CPP (Experiment 4) was formed in males. Extended conditioning with higher dose OT (36 mu g), however, abolished the initial CSP in females and produced an aversion to the OT-paired stimulus mouse. Experiment 5 indicated that it was the repeated administrations rather than the higher dose that produced the abolition of the original preference. Overall, the current results demonstrate for the first time a sex-and stimulus-dependent reinforcing property of intranasal OT in mice.

    DOI

    Scopus

    18
    被引用数
    (Scopus)
  • Asymmetrical generalization of length in the rat

    Yutaka Kosaki, John M. Pearce

    Journal of Experimental Psychology: Animal Learning and Cognition   41 ( 3 ) 266 - 276  2015年07月  [査読有り]

     概要を見る

    Two groups of rats in Experiment 1 were required to escape from a square pool by swimming to 1 of 2 submerged platforms that were situated beside the centers of 2 opposite walls. To help rats find a platform, black panels of equal width were pasted to the middle of the walls that were adjacent to the platforms. The width of the 2 panels was 50 cm for Group 50, and 100 cm for Group 100. Test trials were then conducted in the same pool, but with the platforms removed and with a 50-cm panel on 1 wall and a 100-cm panel on the opposite wall. Group 50 expressed a stronger preference for the 100-cm than the 50-cm panel during the test, whereas Group 100 expressed a similar preference for both panels. Thus the degree of generalization from the short to the long panel was greater than from the long to the short panel. Experiments 2 and 3 pointed to the same conclusion. They were of a similar design to Experiment 1, except that the lengths of the panels for the 2 groups were 25 and 50 cm in Experiment 2, and 25 and 100 cm in Experiment 3. The results are explained by assuming the original training results in the walls without black panels entering into inhibitory associations. This inhibition is then assumed to generalize more to the short than the long test panels and thereby result in an asymmetry in the gradients of generalization between the different lengths.

    DOI PubMed

    Scopus

    1
    被引用数
    (Scopus)
  • Asymmetrical Generalization of Length in the Rat

    Yutaka Kosaki, John M. Pearce

    JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION   41 ( 3 ) 266 - 276  2015年07月  [査読有り]

     概要を見る

    Two groups of rats in Experiment 1 were required to escape from a square pool by swimming to 1 of 2 submerged platforms that were situated beside the centers of 2 opposite walls. To help rats find a platform, black panels of equal width were pasted to the middle of the walls that were adjacent to the platforms. The width of the 2 panels was 50 cm for Group 50, and 100 cm for Group 100. Test trials were then conducted in the same pool, but with the platforms removed and with a 50-cm panel on 1 wall and a 100-cm panel on the opposite wall. Group 50 expressed a stronger preference for the 100-cm than the 50-cm panel during the test, whereas Group 100 expressed a similar preference for both panels. Thus the degree of generalization from the short to the long panel was greater than from the long to the short panel. Experiments 2 and 3 pointed to the same conclusion. They were of a similar design to Experiment 1, except that the lengths of the panels for the 2 groups were 25 and 50 cm in Experiment 2, and 25 and 100 cm in Experiment 3. The results are explained by assuming the original training results in the walls without black panels entering into inhibitory associations. This inhibition is then assumed to generalize more to the short than the long test panels and thereby result in an asymmetry in the gradients of generalization between the different lengths.

    DOI

    Scopus

    1
    被引用数
    (Scopus)
  • Dorsolateral striatal lesions impair navigation based on landmark-goal vectors but facilitate spatial learning based on a ‘cognitive map’

    Kosaki Y, Poulter SL, Austen JM, McGregor A

    Learning & Memory   22 ( 3 ) 179 - 191  2015年03月  [査読有り]

    DOI

    Scopus

    21
    被引用数
    (Scopus)
  • Evidence for concrete but not abstract representation of length during spatial learning in rats

    Julie R. Dumont, Peter M. Jones, John M. Pearce, Yutaka Kosaki

    Journal of Experimental Psychology: Animal Learning and Cognition   41 ( 1 ) 91 - 104  2015年01月  [査読有り]

     概要を見る

    In 4 experiments, rats had to discriminate between the lengths of 2 objects of the same color, black or white, before a test trial with the same objects but of opposite color. The experiments took place in a pool from which rats had to escape by swimming to 1 of 2 submerged platforms. For Experiments 1 and 2, the platforms were situated near the centers of panels of 1 length, but not another, that were pasted onto the gray walls of a square arena. The acquired preference for the correct length was eliminated by changing the color of the panels. In Experiment 3, the platforms were situated near the middle of the long walls of a rectangular pool, and in Experiment 4 they were situated in 1 pair of diagonally opposite corners of the same pool. Changing the color of the walls markedly disrupted the effects of the original training in both experiments. The results indicate that rats represent the length of objects not by their abstract, geometric attributes but in a more concrete fashion such as by a mental snapshot or by the amount of color stimulation they provide.

    DOI PubMed

    Scopus

    1
    被引用数
    (Scopus)
  • 条件づけにおける時間 II -オペラント計時行動,および時間学習の神経機構-

    藤巻峻, 新保彰大, 松井大, 時暁聴, 神前裕

    基礎心理学研究   34   78 - 90  2015年  [査読有り]

    DOI

  • 条件づけにおける時間 I -古典的条件づけ-

    神前裕, 時暁聴, 松井大, 新保彰大, 藤巻峻

    基礎心理学研究   34   60 - 77  2015年  [査読有り]

    DOI

  • げっ歯類における共感性

    神前裕, 渡辺茂

    心理学評論   58 ( 3 ) 276 - 294  2015年  [査読有り]  [招待有り]

    CiNii

  • Evidence for Concrete but Not Abstract Representation of Length During Spatial Learning in Rats

    Julie R. Dumont, Peter M. Jones, John M. Pearce, Yutaka Kosaki

    JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION   41 ( 1 ) 91 - 104  2015年01月  [査読有り]

     概要を見る

    In 4 experiments, rats had to discriminate between the lengths of 2 objects of the same color, black or white, before a test trial with the same objects but of opposite color. The experiments took place in a pool from which rats had to escape by swimming to 1 of 2 submerged platforms. For Experiments 1 and 2, the platforms were situated near the centers of panels of 1 length, but not another, that were pasted onto the gray walls of a square arena. The acquired preference for the correct length was eliminated by changing the color of the panels. In Experiment 3, the platforms were situated near the middle of the long walls of a rectangular pool, and in Experiment 4 they were situated in 1 pair of diagonally opposite corners of the same pool. Changing the color of the walls markedly disrupted the effects of the original training in both experiments. The results indicate that rats represent the length of objects not by their abstract, geometric attributes but in a more concrete fashion such as by a mental snapshot or by the amount of color stimulation they provide.

    DOI

    Scopus

    1
    被引用数
    (Scopus)
  • The Role of the Hippocampus in Passive and Active Spatial Learning

    Yutaka Kosaki, Tzu-Ching Esther Lin, Murray R. Horne, John M. Pearce, Kerry E. Gilroy

    HIPPOCAMPUS   24 ( 12 ) 1633 - 1652  2014年12月  [査読有り]

     概要を見る

    Rats with lesions of the hippocampus or sham lesions were required in four experiments to escape from a square swimming pool by finding a submerged platform. Experiments 1 and 2 commenced with passive training in which rats were repeatedly placed on the platform in one cornerthe correct cornerof a pool with distinctive walls. A test trial then revealed a strong preference for the correct corner in the sham but not the hippocampal group. Subsequent active training of being required to swim to the platform resulted in both groups acquiring a preference for the correct corner in the two experiments. In Experiments 3 and 4, rats were required to solve a discrimination between different panels pasted to the walls of the pool, by swimming to the middle of a correct panel. Hippocampal lesions prevented a discrimination being formed between panels of different lengths (Experiment 3), but not between panels showing lines of different orientations (Experiment 4); rats with sham lesions mastered both problems. It is suggested that an intact hippocampus is necessary for the formation of stimulus-goal associations that permit successful passive spatial leaning. It is further suggested that an intact hippocampus is not necessary for the formation of stimulus-response associations, except when they involve information about length or distance. (c) 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.

    DOI

    Scopus

    20
    被引用数
    (Scopus)
  • Asymmetry in the Discrimination of Length During Spatial Learning

    Yutaka Kosaki, Peter M. Jones, John M. Pearce

    JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES   39 ( 4 ) 342 - 356  2013年10月  [査読有り]

     概要を見る

    The ability of rats to solve a discrimination between two objects that differ in length was investigated in five experiments. Using a rectangular swimming pool, Experiment 1 revealed it is easier to locate a submerged platform when it is near the center of a long rather than a short wall. For Experiments 2-4, the objects were black or white panels pasted onto the gray walls of a square pool, with two long panels pasted to two opposing walls and two short panels pasted to the remaining walls. The platform was easier to locate when it was placed near the middle of a long rather than a short panel. This effect was found when the long panels were twice (Experiments 2-4) or four times the length of the short panels (Experiment 4). Experiment 5 demonstrated that rats can solve a discrimination between panels of length 15 and 45 cm more readily than when they are 70 and 100 cm. The results are consistent with the claim that generalization gradients based on stimulus magnitude are steeper for stimuli that are weaker rather than stronger than the stimulus used for the original training.

    DOI

    Scopus

    9
    被引用数
    (Scopus)
  • Within-Compound Associations Explain Potentiation and Failure to Overshadow Learning Based on Geometry by Discrete Landmarks

    Joe M. Austen, Yutaka Kosaki, Anthony McGregor

    JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES   39 ( 3 ) 259 - 272  2013年07月  [査読有り]

     概要を見る

    In three experiments, rats were trained to locate a submerged platform in one of the base corners of a triangular arena above each of which was suspended one of two distinctive landmarks. In Experiment 1, it was established that these landmarks differed in their salience by the differential control they gained over behavior after training in compound with geometric cues. In Experiment 2, it was shown that locating the platform beneath the less salient landmark potentiated learning based on geometry compared with control rats for which landmarks provided ambiguous information about the location of the platform. The presence of the more salient landmark above the platform for another group of animals appeared to have no effect on learning based on geometry. Experiment 3 established that these landmark and geometry cues entered into within-compound associations during compound training. We argue that these within-compound associations can account for the potentiation seen in Experiment 2, as well as previous failures to demonstrate overshadowing of geometric cues. We also suggest that these within-compound associations need not be of different magnitudes, despite the different effects of each of the landmarks on learning based on geometry seen in Experiment 2. Instead, within-compound associations appear to mitigate the overshadowing effects that traditional theories of associative learning would predict.

    DOI

    Scopus

    14
    被引用数
    (Scopus)
  • Overshadowing of Geometry Learning by Discrete Landmarks in the Water Maze: Effects of Relative Salience and Relative Validity of Competing Cues

    Yutaka Kosaki, Joe M. Austen, Anthony McGregor

    JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES   39 ( 2 ) 126 - 139  2013年04月  [査読有り]

     概要を見る

    The effects of stimulus salience and cue validity in the overshadowing of geometric features of an enclosed arena by discrete landmarks were investigated in rats using the water maze paradigm. Experiment 1 established that in h rhomboid-shaped arena, the acute corner was more salient than the obtuse corner. In Experiment 2, rats were trained to find a submerged platform either in one of the acute, or obtuse, corners. In addition to the information provided by corner angle, the platform was also signaled by the presence of a spherical landmark suspended above the platform for rats in the experimental group. The landmark was a more valid cue for predicting the location of the platform than the angle of the corner. This training resulted in overshadowing of learning about the angle of the corner by the presence of the landmark. The final experiment extended this result by showing that when the predictive validities of the angle and the landmark were matched in the experimental group, learning about geometry was still overshadowed by the presence of landmarks, but only in animals that were trained with the platform at an obtuse, but not acute, corner. These results uniquely demonstrate that learning about geometry can be overshadowed by discrete landmarks, and also that whether overshadowing is observed depends on the stimulus salience and the relative validity of the competing cues. These findings imply that learning based on geometric cues follows the same basic rules that apply to a wide range of other learning paradigms.

    DOI

  • Spontaneous object recognition memory is maintained following transformation of global geometric properties

    Poulter SL, Kosaki Y, Easton A, McGregor A

    Journal of Experimental Psychology: Animal Behavior Processes   39 ( 1 ) 93 - 98  2013年  [査読有り]

    DOI

    Scopus

    8
    被引用数
    (Scopus)
  • Dissociable roles of the medial prefrontal cortex, the anterior cingulate cortex, and the hippocampus in behavioural flexibility revealed by serial reversal of three-choice discrimination in rats

    Yutaka Kosaki, Shigeru Watanabe

    BEHAVIOURAL BRAIN RESEARCH   227 ( 1 ) 81 - 90  2012年02月  [査読有り]

     概要を見る

    Contributions of different limbic cortical areas to mediation of behavioural flexibility were examined using repeated acquisition of three-choice discrimination in operant chambers. Rats were trained on a series of positional discrimination tasks with three levers, where position of the correct lever remained the same within a task but shifted across tasks. Ibotenic acid lesions of the medial prefrontal cortex impaired acquisition of each discrimination task by increasing errors specifically in the early phase of each task. These errors were characterised by perseveration to the previously correct lever. By contrast, lesions of the anterior cingulate cortex resulted in the impairment of discrimination in general without inducing perseveration; the impairment was instead characterised by disruption of general error-correction processes. Hippocampal lesions severely impaired learning by increasing perseverative tendencies that were present throughout the learning stages in each task. These results extend our understanding of the contributions of the different nodes of the limbic cortico-striatal circuit to different aspects of behavioural flexibility. (C) 2011 Elsevier B.V. All rights reserved.

    DOI

    Scopus

    29
    被引用数
    (Scopus)
  • Choice and Contingency in the Development of Behavioral Autonomy During Instrumental Conditioning

    Yutaka Kosaki, Anthony Dickinson

    JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES   36 ( 3 ) 334 - 342  2010年07月  [査読有り]

     概要を見る

    In two experiments hungry rats received extensive training to lever press for food outcomes before one outcome was devalued by aversion conditioning and responding tested in extinction. If the rats were trained on a concurrent schedule in which two responses yielded different outcomes, performance during the extinction test was reduced by devaluation of the associated outcome. By contrast, if a single response was trained concurrently with the noncontingent presentations of the other outcome, test performance was insensitive to devaluation of the contingent outcome. This finding demonstrates that training on a schedule that offers a choice between responses that yield different outcomes prevents the onset of behavioral autonomy.

    DOI

    Scopus

    59
    被引用数
    (Scopus)
  • The role of contextual conditioning in the effect of reinforcer devaluation on instrumental performance by rats

    Sietse Jonkman, Yutaka Kosaki, Barry J. Everitt, Anthony Dickinson

    BEHAVIOURAL PROCESSES   83 ( 3 ) 276 - 281  2010年03月  [査読有り]

     概要を見る

    Different groups of rats received different amounts of training to lever press for a food reinforcer before an aversion was conditioned to the food. This devaluation of the reinforcer reduced responding in both subsequent extinction and reinforced tests of responding to a degree that was independent of the amount of instrumental training. Moreover, interpolating context extinction between aversion conditioning and the extinction test reduced the magnitude of the devaluation effect, thereby indicating that Pavlovian contextual conditioning may play a role in the instrumental devaluation effect. (C) 2010 Elsevier B.V. All rights reserved.

    DOI

    Scopus

    15
    被引用数
    (Scopus)
  • Dorsomedial prefrontal cortex resolves response conflict in rats

    S De Wit, Y Kosaki, BW Balleine, A Dickinson

    JOURNAL OF NEUROSCIENCE   26 ( 19 ) 5224 - 5229  2006年05月  [査読有り]

     概要を見る

    The capacity for goal-directed behavior requires not only the encoding of the response-outcome relationship but also the ability to resolve conflict induced by competing responses. Recent neuroimaging studies have identified the prefrontal cortex as critical for resolving conflict between competing responses. At present, however, much of this evidence is indirect, and the necessity of dorsomedial prefrontal cortex (dmPFC) function for the resolution of conflict in goal-directed behavior has not been assessed. Here, we develop a rodent paradigm to investigate response conflict caused by the concurrent activation of a correct and incorrect response. In this paradigm, the outcome of one response also acts as a discriminative stimulus signaling that the other response is correct. Whereas rats with a functional dmPFC are able to resolve this conflict, inactivation of dmPFC using an infusion of muscimol produced a deficit by selectively interfering with their ability to inhibit the incorrect, competing response.

    DOI

    Scopus

    51
    被引用数
    (Scopus)

▼全件表示

書籍等出版物

  • Evolutionary Origin of Empathy and Inequality Aversion. In S. Watanabe, M. Hofman, & T. Shimizu (Eds.), Evolution of the Brain, Cognition, and Emotion in Vertebrates

    Shigeru Watanabe, Yutaka Kosaki( 担当: 分担執筆,  担当範囲: pp. 273-299)

    Springer, Tokyo  2017年

  • Cognitive functions of the medial prefrontal cortex in rats. In S. Watanabe (Ed.), Comparative Analysis of Mind.

    Yutaka Kosaki( 担当: 分担執筆,  担当範囲: Chapter 4. (pp. 73-98))

    Keio University Press (Tokyo)  2004年

Misc

  • IP005 レバー位置弁別の連続獲得におけるラット海馬 : 内側前頭前野系の役割

    神前 裕, 渡辺 茂

    動物心理学研究   53 ( 2 )  2003年12月

    CiNii

  • メタンフェタミン条件性場所選好の獲得および表出に対する側坐核および前頭前野内ハロペリドール投与の効果

    神前 裕, 池田 元子, 渡辺 茂

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   22 ( 6 ) 276 - 276  2002年12月

    CiNii

  • P-2-4 空間弁別学習の反復獲得課題におけるラット内側前頭前野,帯状皮質吻側部,および帯状皮質尾側部損傷の効果

    神前 裕, 渡辺 茂

    動物心理学研究   52 ( 2 )  2002年12月

    CiNii

受賞

  • 早稲田リサーチアワード(国際研究発信力)

    2018年  

    受賞者: 神前裕

  • 印東太郎賞

    2018年  

    受賞者: 神前裕

  • 日本基礎心理学会優秀論文賞

    2016年  

    受賞者: 藤巻峻, 新保彰大, 松井大, 時暁聴, 神前裕

  • 中島記念国際交流財団 日本人留学生奨学金

    2004年  

    受賞者: 神前裕

共同研究・競争的資金等の研究課題

  • 随意行動の消去に関する連合学習およびシステム神経科学的検証

    文部科学省  科研費基盤研究(B)

    研究期間:

    2019年
    -
    2021年
     

    神前裕

  • 目的的行動から習慣行動への遷移を支える微視的理論と依存研究への応用

    文部科学省  科研費基盤研究(B)

    研究期間:

    2018年
    -
    2021年
     

    澤幸祐

  • 負の強化メカニズムを通じた薬物依存形成の行動神経薬理学的検討

    文部科学省  科研費国際共同研究加速基金(国際共同研究強化)

    研究期間:

    2018年
    -
    2021年
     

    神前裕

  • 事象間の随伴性と接近性に依存する学習の行動神経薬理学的メカニズムの検討

    文部科学省  科研費若手研究(B)

    研究期間:

    2016年04月
    -
    2019年03月
     

    神前裕

  • 目的的行動におけるラット前帯状皮質の役割の検討

    文部科学省  科研費研究活動スタート支援

    研究期間:

    2014年08月
    -
    2016年03月
     

    神前裕

講演・口頭発表等

  • What we talk about when we talk about conditioning

    神前裕  [招待有り]

    第5回 印東太郎賞 受賞記念講演  

    発表年月: 2018年10月

  • 薬物依存と連合過程の変容について

    神前裕  [招待有り]

    薬物・精神・行動の会  

    発表年月: 2018年10月

  • マウスにおける薬物条件づけ:メタンフェタミンをUSとした複合条件づけにおける場所選好と匂い嫌悪の並立獲得

    神前裕  [招待有り]

    日本心理学会第82回大会  

    発表年月: 2018年09月

  • メタンフェタミンをUSとした複合条件づにおいて同時に獲得される場所選好と匂い嫌悪: 薬物依存の心理学的プロセスに対する考察

    神前裕  [招待有り]

    平成30年度 アルコール・薬物依存関連学会合同学術総会  

    発表年月: 2018年09月

  • 空間的学習と非空間的学習の接点:学習理論の一般性について

    神前裕  [招待有り]

    第23回CAPS研究会(関西学院大学)  

    発表年月: 2018年01月

  • Highs and lows of drug reward: A study in mice with modified CPP paradigm

    神前裕  [招待有り]

    International Symposium on Evolution of Brain, Cognition, and Emotion  

    発表年月: 2017年10月

  • 連合学習理論から行動の制御を考える

    神前裕  [招待有り]

    日本認知・行動療法学会 第43回大会  

    発表年月: 2017年09月

  • From conditioning to social behaviour

    神前裕  [招待有り]

    Biopsycho Symposium  

    発表年月: 2017年03月

  • Concurrent development of conditioned place preference and object aversion in place-object compound conditioning with methamphetamine US: Implications for opponent-process theories of drug conditioning

    神前裕

    Neuroscience 2016 (SFN annual meeting)  

    発表年月: 2016年11月

  • 事象間の随伴性判断と意図的行動の機構について

    神前裕  [招待有り]

    北海道大学CERSSワークショップ  

    発表年月: 2016年11月

  • オペラント学習における連合過程とその神経基盤について

    神前裕  [招待有り]

    第24回行動数理研究会(チュートリアル講演)  

    発表年月: 2016年09月

  • Towards an integrative understanding of cognitive and behavioural views of animal learning

    神前裕  [招待有り]

    International Congress of Psychology (ICP) 2016  

    発表年月: 2016年07月

  • BTBR T+ tfマウスにおける連合学習の刺激選択的障害

    神前裕

    日本動物心理学会第161回例会  

    発表年月: 2015年09月

  • Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice

    神前裕

    The 75th Annual Meeting of the Japanese Society for Animal Psychology  

    発表年月: 2015年09月

  • The hippocampus and place learning revisited: potential interactions between multiple learning systems in the rat brain

    神前裕  [招待有り]

    International symposium on the avian brains: another high function brain  

    発表年月: 2015年08月

  • Asymmetric generalisation of different lengths in the rat

    神前裕

    The 74th Annual Meeting of the Japanese Society for Animal Psychology  

    発表年月: 2014年07月

  • Navigation, association, and multiple learning systems in the brain

    神前裕  [招待有り]

    The 140th Bio-Psycho Symposium  

    発表年月: 2014年05月

  • Asymmetry in the discrimination of length during spatial learning

    神前裕

    The 17th Associative Learning Symposium (Gregynog)  

    発表年月: 2013年04月

  • Lesions of the dorsolateral striatum impair spatial learning based on the landmark-goal vector but facilitate cognitive mapping in the rat

    神前裕

    The 43rd Meeting of the European Brain and Behavior Society (EBBS)  

    発表年月: 2011年09月

  • Overshadowing and potentiation of geometry learning by discrete landmarks in the watermaze: the effect of stimulus salience

    神前裕

    14th Associative learning symposium (Gregynog)  

    発表年月: 2010年03月

  • The role of choice and contingency in development of behavioural autonomy

    神前裕

    13th Associative learning symposium (Gregynog)  

    発表年月: 2009年04月

  • Contextual control of habit formation with multiple reinforcers

    神前裕

    11th Associative learning symposium (Gregynog)  

    発表年月: 2007年03月

▼全件表示

学内研究費(特定課題)

  • ラットを用いた依存形成の行動メカニズムについての実験的検討

    2018年  

     概要を見る

    薬物やギャンブルへの依存の行動メカニズムを検証するためラット・マウスを用いて実験を行なった。実験1では、レバー押し行動と報酬との間の随伴性を変化させた際に、覚せい剤を慢性事前投与された群では随伴性追従の程度が低下することを示した。実験2では、マウスを用いて覚せい剤またはニコチンの投与がギャンブル用行動に与える影響をオペラント課題において検証した。反応に対して報酬が一定の割合で与えられる選択肢よりも、反応に対して変動する割合で報酬が与えられる選択肢に対する選好がニコチン投与により増加することが確認された。本研究課題により、依存形成のメカニズム解明に向けて重要なデータを得ることができた。

  • 自閉症モデル系統マウスにおける随意行動と結果との随伴性に対する感受性の検討

    2017年  

     概要を見る

    自閉症スペクトラム障害の基礎的メカニズムとして、事象間の随伴性判断に障害が見られるか、マウスモデルを用いて検討した。道具的条件づけ手続きを用い、レバー押し行動と餌報酬との間の随伴性を操作し、随伴性操作に対する行動の感受性を自閉症モデル系統のBTBT T+/tfマウスと標準的なC57BL/6マウスにて比較した。実験1・2において、異なる種類の強化子を用いてレバー押しを訓練したが、いずれにおいても、 C57系統に比べ、BTBR系統では 訓練に用いた間欠強化スケジュールでの要求反応比率を上昇させると反応が維持されなくなり、安定した反応率を維持する事が出来なかった。実験3ではFR3での最小限の訓練後、強化子低価値化手続きを用いて、行動に伴う結果表象の有無を検証した。BTBR系統では低価値化の効果が傾向として認められたが、統制群であるC57系統で低価値化効果が見られなかった。いずれの実験においても、実験手続きの更なる改良が必要であることが明らかになった。

 

現在担当している科目

▼全件表示

担当経験のある科目(授業)

  • 心理学概論

    早稲田大学  

  • 心理学演習(実習)

    早稲田大学  

  • 学習心理学実験

    早稲田大学  

  • フィールド実習

    早稲田大学  

  • 学習心理学

    早稲田大学  

  • 神経科学特殊IV: 情動と学習の神経科学

    慶應義塾大学  

  • Psychological Measurement and Evaluation (in English)

    国際基督教大学(ICU)  

  • Biological Basis of Mind and Behaviour (in English)

    国際基督教大学(ICU)  

  • 生理と心理(生理心理学入門)

    昭和女子大学  

  • 生理心理学

    昭和女子大学  

  • 学習と記憶

    国立障害者リハビリテーションセンター学院  

▼全件表示

 

委員歴

  • 2017年
    -
    継続中

    日本動物心理学会  「動物心理学研究」編集幹事