Updated on 2024/04/17

写真a

 
KOSAKI, Yutaka
 
Affiliation
Faculty of Letters, Arts and Sciences, School of Humanities and Social Sciences
Job title
Professor
Degree
PhD ( University of Cambridge )

Research Experience

  • 2022.04
    -
    Now

    Waseda University   School of Humanities and Social Sciences   Professor

  • 2017.04
    -
    2022.03

    Waseda University   Department of Psychology, School of Humanities and Social Sciences   Associate Professor

  • 2015.12
    -
    2017.03

    Keio University   Advanced Research Centers   Assistant Professor

  • 2014.04
    -
    2015.11

    Keio University   Advanced Research Centers   Research Associate

  • 2011.11
    -
    2014.03

    Cardiff University   School of Psychology   Research Associate

  • 2008.11
    -
    2011.10

    Durham University   Department of Psychology   Research Associate

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Education Background

  •  
    -
    2008.11

    University of Cambridge (PhD)   Department of Experimental Psychology  

Committee Memberships

  • 2017
    -
    Now

    日本動物心理学会  「動物心理学研究」編集幹事

Professional Memberships

  •  
     
     

    THE JAPAN NEUROSCIENCE SOCIETY

  •  
     
     

    JAPANESE SOCIETY FOR ANIMAL PSYCHOLOGY

Research Areas

  • Experimental psychology   Associative learning theory / Neuroscience-general   Behavioural Neuroscience

Research Interests

  • Pavlovian conditioning

  • Instrumental conditioning

  • Learning and behaviour

  • Behavioural neuroscience

  • Goal-directed behaviour

  • Stimulus-response habit

  • Spatial learning

  • Stimulus competition

  • Associative learning theory

  • Multiple memory systems

  • Hippocampus

  • Prefrontal cortex

  • Anterior cingulate cortex

  • Striatum

  • Social behaviour

  • Reinforcement learning

▼display all

Awards

  • 早稲田リサーチアワード(国際研究発信力)

    2018  

    Winner: 神前裕

  • 印東太郎賞

    2018  

    Winner: 神前裕

  • 日本基礎心理学会優秀論文賞

    2016  

    Winner: 藤巻峻, 新保彰大, 松井大, 時暁聴, 神前裕

  • 中島記念国際交流財団 日本人留学生奨学金

    2004  

    Winner: 神前裕

 

Papers

  • Transition between habits and goal-directed actions in the renewal effect.

    Shun Fujimaki, Yutaka Kosaki

    Journal of Experimental Psychology: Animal Learning and Cognition   49 ( 4 ) 209 - 225  2023.10  [Refereed]

    Authorship:Last author, Corresponding author

    DOI

    Scopus

  • Kamin blocking is disrupted by low-dose ketamine in mice: Further implications for aberrant stimulus processing in schizophrenia.

    Riria Suzuki, Kenji Yamaguchi, Yutaka Kosaki

    Behavioral Neuroscience    2023.09  [Refereed]

    Authorship:Last author, Corresponding author

    DOI

    Scopus

  • Resurgence of goal‐directed actions and habits

    Shun Fujimaki, Ting Hu, Yutaka Kosaki

    Journal of the Experimental Analysis of Behavior    2023.09  [Refereed]

    Authorship:Last author

     View Summary

    Abstract

    This study investigated how goal‐directed and habitual behaviors recover after extinction within the context of the resurgence effect, a form of relapse induced by the removal or worsening of alternative reinforcement. Rats were trained to press a target lever with one reinforcer (O1) for either minimal (4) or extended (16) sessions. An extinction test after the completion of O1 devaluation confirmed that minimal and extended training formed goal‐directed and habitual behaviors, respectively. Then, pressing an alternative lever was reinforced with a second reinforcer (O2) while the target response was placed on extinction. When O2 was discontinued, the minimally trained target response resurged with goal‐directed status as in the extinction test. However, the extinguished habitual behavior in the extensively trained rats did not recover as a habit but instead with goal‐directed status, possibly due to the context specificity of habits or the introduction of a new response–reinforcer contingency. The critical finding that reinforcer devaluation consistently led to less resurgence regardless of the amount of acquisition training provides a clinical implication that coupling differential‐reinforcement‐of‐alternative‐behavior (DRA) treatments with the devaluation of the associated reinforcer of problematic behavior could effectively diminish its recurrence.

    DOI

    Scopus

    1
    Citation
    (Scopus)
  • Ketamine facilitates appetitive trace conditioning in mice: Further evidence for abnormal stimulus representation in schizophrenia model animals.

    Riria Suzuki, Yutaka Kosaki

    Behavioral Neuroscience   137 ( 4 ) 236 - 253  2023.08  [Refereed]

    Authorship:Last author, Corresponding author

    DOI

    Scopus

    1
    Citation
    (Scopus)
  • Measurement of the exploration–exploitation response of dogs through a concurrent visual discrimination task

    Kumi Shinoda, Yutaka Kosaki, Miho Nagasawa, Takefumi Kikusui

    Behavioural Processes   199   104644  2022.06  [Refereed]

    DOI

    Scopus

    1
    Citation
    (Scopus)
  • Higher-Order Conditioning in the Spatial Domain

    Youcef Bouchekioua, Yutaka Kosaki, Shigeru Watanabe, Aaron P. Blaisdell

    Frontiers in Behavioral Neuroscience   15  2021.11  [Refereed]

     View Summary

    Spatial learning and memory, the processes through which a wide range of living organisms encode, compute, and retrieve information from their environment to perform goal-directed navigation, has been systematically investigated since the early twentieth century to unravel behavioral and neural mechanisms of learning and memory. Early theories about learning to navigate space considered that animals learn through trial and error and develop responses to stimuli that guide them to a goal place. According to a trial-and error learning view, organisms can learn a sequence of motor actions that lead to a goal place, a strategy referred to as response learning, which contrasts with place learning where animals learn locations with respect to an allocentric framework. Place learning has been proposed to produce a mental representation of the environment and the cartesian relations between stimuli within it—which Tolman coined the cognitive map. We propose to revisit some of the best empirical evidence of spatial inference in animals, and then discuss recent attempts to account for spatial inferences within an associative framework as opposed to the traditional cognitive map framework. We will first show how higher-order conditioning can successfully account for inferential goal-directed navigation in a variety of situations and then how vectors derived from path integration can be integrated via higher-order conditioning, resulting in the generation of higher-order vectors that explain novel route taking. Finally, implications to cognitive map theories will be discussed.

    DOI

    Scopus

  • Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions

    Steven L. Poulter, Yutaka Kosaki, David J. Sanderson, Anthony McGregor

    Brain and Neuroscience Advances   4   239821282097259 - 239821282097259  2020.11  [Refereed]

     View Summary

    We examined the role of the hippocampus and the dorsolateral striatum in the representation of environmental geometry using a spontaneous object recognition procedure. Rats were placed in a kite-shaped arena and allowed to explore two distinctive objects in each of the right-angled corners. In a different room, rats were then placed into a rectangular arena with two identical copies of one of the two objects from the exploration phase, one in each of the two adjacent right-angled corners that were separated by a long wall. Time spent exploring these two objects was recorded as a measure of recognition memory. Since both objects were in different locations with respect to the room (different between exploration and test phases) and the global geometry (also different between exploration and test phases), differential exploration of the objects must be a result of initial habituation to the object relative to its local geometric context. The results indicated an impairment in processing the local geometric features of the environment for both hippocampus and dorsolateral striatum lesioned rats compared with sham-operated controls, though a control experiment showed these rats were unimpaired in a standard object recognition task. The dorsolateral striatum has previously been implicated in egocentric route-learning, but the results indicate an unexpected role for the dorsolateral striatum in processing the spatial layout of the environment. The results provide the first evidence that lesions to the hippocampus and dorsolateral striatum impair spontaneous encoding of local environmental geometric features.

    DOI

  • Spatial inference without a cognitive map: the role of higher‐order path integration

    Youcef Bouchekioua, Aaron P. Blaisdell, Yutaka Kosaki, Iku Tsutsui‐Kimura, Paul Craddock, Masaru Mimura, Shigeru Watanabe

    Biological Reviews   96 ( 1 ) 52 - 65  2020.09  [Refereed]

    DOI PubMed

    Scopus

    6
    Citation
    (Scopus)
  • En route to delineating hippocampal roles in spatial learning.

    Poulter, S, Austen, J. M, Kosaki, Y, Dachtler, J, Lever, C, McGregor, A

    Behavioural Brain Research   369 ( online first publication )  2019  [Refereed]

  • Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

    Youcef Bouchekioua, Iku Tsutsui-Kimura, Hiromi Sano, Miwako Koizumi, Kenji F. Tanaka, Keitaro Yoshida, Yutaka Kosaki, Shigeru Watanabe, Masaru Mimura

    Neuroscience Research   132   53 - 57  2018.07  [Refereed]

     View Summary

    Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

    DOI

    Scopus

    17
    Citation
    (Scopus)
  • The response strategy and the place strategy in a plus-maze have different sensitivities to devaluation of expected outcome

    Yutaka Kosaki, John M. Pearce, Anthony McGregor

    Hippocampus   28 ( 7 ) 484 - 496  2018.04  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    16
    Citation
    (Scopus)
  • Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits

    Akihiro Shimbo, Yutaka Kosaki, Isao Ito, Shigeru Watanabe

    BEHAVIOURAL BRAIN RESEARCH   336   156 - 165  2018.01  [Refereed]

     View Summary

    Left-right asymmetry is known to exist at several anatomical levels in the brain and recent studies have provided further evidence to show that it also exists at a molecular level in the hippocampal CA3-CA1 circuit. The distribution of N-methyl-o-aspartate (NMDA) receptor NR2B subunits in the apical and basal synapses of CA1 pyramidal neurons is asymmetrical if the input arrives from the left or right CA3 pyramidal neurons. In the present study, we examined the role of hippocampal asymmetry in cognitive function using beta 2-microglobulin knock-out (Pm KO) mice, which lack hippocampal asymmetry. We tested beta 2m KO mice in a series of spatial and non-spatial learning tasks and compared the performances of beta 2m KO and C57BL6/J wild-type (WT) mice. The beta 2m KO mice appeared normal in both spatial reference memory and spatial working memory tasks but they took more time than WT mice in learning the two non-spatial learning tasks (i.e., a differential reinforcement of lower rates of behavior (DRL) task and a straight runway task). The beta 2m KO mice also showed less precision in their response timing in the DRL task and showed weaker spontaneous recovery during extinction in the straight runway task. These results indicate that hippocampal asymmetry is important for certain characteristics of non spatial learning.

    DOI

    Scopus

    6
    Citation
    (Scopus)
  • Impaired Pavlovian predictive learning between temporally phasic but not static events in autism-model strain mice

    Yutaka Kosaki, Shigeru Watanabe

    Neurobiology of Learning and Memory   134   304 - 316  2016.10  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    3
    Citation
    (Scopus)
  • Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice.

    Yutaka Kosaki, Shigeru Watanabe

    Behavioral Neuroscience   130 ( 2 ) 182 - 195  2016.04  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    20
    Citation
    (Scopus)
  • Asymmetrical generalization of length in the rat.

    Yutaka Kosaki, John M. Pearce

    Journal of Experimental Psychology: Animal Learning and Cognition   41 ( 3 ) 266 - 276  2015.07  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI PubMed

    Scopus

    1
    Citation
    (Scopus)
  • Dorsolateral striatal lesions impair navigation based on landmark-goal vectors but facilitate spatial learning based on a “cognitive map”

    Yutaka Kosaki, Steven L. Poulter, Joe M. Austen, Anthony McGregor

    Learning & Memory   22 ( 3 ) 179 - 191  2015.02  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    In three experiments, the nature of the interaction between multiple memory systems in rats solving a variation of a spatial task in the water maze was investigated. Throughout training rats were able to find a submerged platform at a fixed distance and direction from an intramaze landmark by learning a landmark-goal vector. Extramaze cues were also available for standard place learning, or “cognitive mapping,” but these cues were valid only within each session, as the position of the platform moved around the pool between sessions together with the intramaze landmark. Animals could therefore learn the position of the platform by taking the consistent vector from the landmark across sessions or by rapidly encoding the new platform position on each session with reference to the extramaze cues. Excitotoxic lesions of the dorsolateral striatum impaired vector-based learning but facilitated cognitive map-based rapid place learning when the extramaze cues were relatively poor (Experiment 1) but not when they were more salient (Experiments 2 and 3). The way the lesion effects interacted with cue availability is consistent with the idea that the memory systems involved in the current navigation task are functionally cooperative yet associatively competitive in nature.

    DOI

    Scopus

    25
    Citation
    (Scopus)
  • Evidence for concrete but not abstract representation of length during spatial learning in rats.

    Julie R. Dumont, Peter M. Jones, John M. Pearce, Yutaka Kosaki

    Journal of Experimental Psychology: Animal Learning and Cognition   41 ( 1 ) 91 - 104  2015.01  [Refereed]

    Authorship:Last author

    DOI PubMed

    Scopus

    1
    Citation
    (Scopus)
  • Roles of temporal information in conditioning II: Operant conditioning, and neural substrates of timing

    Shun Fujimaki, Akihiro Shimbo, Hiroshi Matsui, Xiating Shi, Yutaka Kosaki

    The Japanese Journal of Psychonomic Science   34   78 - 90  2015  [Refereed]

    Authorship:Last author, Corresponding author

    DOI

  • Roles of temporal information in conditioning I: Classical conditioning

    Yutaka Kosaki, Xiating Shi, Hiroshi Matsui, Akihiro Shimbo, Shun Fujimaki

    The Japanese Journal of Psychonomic Science   34   60 - 77  2015  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

  • Empathy in rodents

    Yutaka Kosaki, Shigeru Watanabe

    Japanese Psychological Review   58 ( 3 ) 276 - 294  2015  [Refereed]  [Invited]

    Authorship:Lead author

    CiNii

  • The role of the hippocampus in passive and active spatial learning

    Yutaka Kosaki, Tzu-Ching Esther Lin, Murray R. Horne, John M. Pearce, Kerry E. Gilroy

    Hippocampus   24 ( 12 ) 1633 - 1652  2014.08  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    23
    Citation
    (Scopus)
  • Asymmetry in the discrimination of length during spatial learning.

    Yutaka Kosaki, Peter M. Jones, John M. Pearce

    Journal of Experimental Psychology: Animal Behavior Processes   39 ( 4 ) 342 - 356  2013.10  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    9
    Citation
    (Scopus)
  • Overshadowing of Geometry Learning by Discrete Landmarks in the Water Maze: Effects of Relative Salience and Relative Validity of Competing Cues

    Yutaka Kosaki, Joe M. Austen, Anthony McGregor

    Journal of Experimental Psychology: Animal Behavior Processes   39 ( 2 ) 126 - 139  2013.04  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    The effects of stimulus salience and cue validity in the overshadowing of geometric features of an enclosed arena by discrete landmarks were investigated in rats using the water maze paradigm. Experiment 1 established that in h rhomboid-shaped arena, the acute corner was more salient than the obtuse corner. In Experiment 2, rats were trained to find a submerged platform either in one of the acute, or obtuse, corners. In addition to the information provided by corner angle, the platform was also signaled by the presence of a spherical landmark suspended above the platform for rats in the experimental group. The landmark was a more valid cue for predicting the location of the platform than the angle of the corner. This training resulted in overshadowing of learning about the angle of the corner by the presence of the landmark. The final experiment extended this result by showing that when the predictive validities of the angle and the landmark were matched in the experimental group, learning about geometry was still overshadowed by the presence of landmarks, but only in animals that were trained with the platform at an obtuse, but not acute, corner. These results uniquely demonstrate that learning about geometry can be overshadowed by discrete landmarks, and also that whether overshadowing is observed depends on the stimulus salience and the relative validity of the competing cues. These findings imply that learning based on geometric cues follows the same basic rules that apply to a wide range of other learning paradigms.

    DOI

  • Spontaneous object recognition memory is maintained following transformation of global geometric properties.

    Steven L. Poulter, Yutaka Kosaki, Alexander Easton, Anthony McGregor

    Journal of Experimental Psychology: Animal Behavior Processes   39 ( 1 ) 93 - 98  2013  [Refereed]

    DOI

    Scopus

    8
    Citation
    (Scopus)
  • Within-compound associations explain potentiation and failure to overshadow learning based on geometry by discrete landmarks.

    Joe M. Austen, Yutaka Kosaki, Anthony McGregor

    Journal of Experimental Psychology: Animal Behavior Processes   39 ( 3 ) 259 - 272  2013  [Refereed]

    DOI

    Scopus

    14
    Citation
    (Scopus)
  • Dissociable roles of the medial prefrontal cortex, the anterior cingulate cortex, and the hippocampus in behavioural flexibility revealed by serial reversal of three-choice discrimination in rats

    Yutaka Kosaki, Shigeru Watanabe

    Behavioural Brain Research   227 ( 1 ) 81 - 90  2012.02  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

    Scopus

    30
    Citation
    (Scopus)
  • Choice and contingency in the development of behavioral autonomy during instrumental conditioning.

    Yutaka Kosaki, Anthony Dickinson

    Journal of Experimental Psychology: Animal Behavior Processes   36 ( 3 ) 334 - 342  2010.07  [Refereed]

    Authorship:Lead author

    DOI

    Scopus

    74
    Citation
    (Scopus)
  • The role of contextual conditioning in the effect of reinforcer devaluation on instrumental performance by rats

    Sietse Jonkman, Yutaka Kosaki, Barry J. Everitt, Anthony Dickinson

    Behavioural Processes   83 ( 3 ) 276 - 281  2010.03  [Refereed]

     View Summary

    Different groups of rats received different amounts of training to lever press for a food reinforcer before an aversion was conditioned to the food. This devaluation of the reinforcer reduced responding in both subsequent extinction and reinforced tests of responding to a degree that was independent of the amount of instrumental training. Moreover, interpolating context extinction between aversion conditioning and the extinction test reduced the magnitude of the devaluation effect, thereby indicating that Pavlovian contextual conditioning may play a role in the instrumental devaluation effect. (C) 2010 Elsevier B.V. All rights reserved.

    DOI

    Scopus

    18
    Citation
    (Scopus)
  • Dorsomedial prefrontal cortex resolves response conflict in rats

    S De Wit, Y Kosaki, BW Balleine, A Dickinson

    Journal of Neuroscience   26 ( 19 ) 5224 - 5229  2006.05  [Refereed]

     View Summary

    The capacity for goal-directed behavior requires not only the encoding of the response-outcome relationship but also the ability to resolve conflict induced by competing responses. Recent neuroimaging studies have identified the prefrontal cortex as critical for resolving conflict between competing responses. At present, however, much of this evidence is indirect, and the necessity of dorsomedial prefrontal cortex (dmPFC) function for the resolution of conflict in goal-directed behavior has not been assessed. Here, we develop a rodent paradigm to investigate response conflict caused by the concurrent activation of a correct and incorrect response. In this paradigm, the outcome of one response also acts as a discriminative stimulus signaling that the other response is correct. Whereas rats with a functional dmPFC are able to resolve this conflict, inactivation of dmPFC using an infusion of muscimol produced a deficit by selectively interfering with their ability to inhibit the incorrect, competing response.

    DOI

    Scopus

    53
    Citation
    (Scopus)

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Books and Other Publications

  • 動物心理学入門 -- 動物行動研究から探るヒトのこころの世界

    神前裕( Part: Contributor, なぜ道を覚えられるの?(海馬と空間学習))

    有斐閣  2023.07 ISBN: 9784641174887

  • Evolutionary Origin of Empathy and Inequality Aversion. In S. Watanabe, M. Hofman, & T. Shimizu (Eds.), Evolution of the Brain, Cognition, and Emotion in Vertebrates

    Shigeru Watanabe, Yutaka Kosaki( Part: Contributor, pp. 273-299)

    Springer, Tokyo  2017

  • Cognitive functions of the medial prefrontal cortex in rats. In S. Watanabe (Ed.), Comparative Analysis of Mind.

    Yutaka Kosaki( Part: Contributor, Chapter 4. (pp. 73-98))

    Keio University Press (Tokyo)  2004

Presentations

  • 動物行動研究の新しいトレンド――習慣から依存への進展における負情動の発達を捉える――

    神前裕  [Invited]

    アルコール・薬物依存関連学会合同学術総会 

    Presentation date: 2022.09

  • What we talk about when we talk about conditioning

    神前裕  [Invited]

    第5回 印東太郎賞 受賞記念講演 

    Presentation date: 2018.10

  • 薬物依存と連合過程の変容について

    神前裕  [Invited]

    薬物・精神・行動の会 

    Presentation date: 2018.10

  • マウスにおける薬物条件づけ:メタンフェタミンをUSとした複合条件づけにおける場所選好と匂い嫌悪の並立獲得

    神前裕  [Invited]

    日本心理学会第82回大会 

    Presentation date: 2018.09

  • メタンフェタミンをUSとした複合条件づにおいて同時に獲得される場所選好と匂い嫌悪: 薬物依存の心理学的プロセスに対する考察

    神前裕  [Invited]

    平成30年度 アルコール・薬物依存関連学会合同学術総会 

    Presentation date: 2018.09

  • 空間的学習と非空間的学習の接点:学習理論の一般性について

    神前裕  [Invited]

    第23回CAPS研究会(関西学院大学) 

    Presentation date: 2018.01

  • Highs and lows of drug reward: A study in mice with modified CPP paradigm

    神前裕  [Invited]

    International Symposium on Evolution of Brain, Cognition, and Emotion 

    Presentation date: 2017.10

  • 連合学習理論から行動の制御を考える

    神前裕  [Invited]

    日本認知・行動療法学会 第43回大会 

    Presentation date: 2017.09

  • From conditioning to social behaviour

    神前裕  [Invited]

    Biopsycho Symposium 

    Presentation date: 2017.03

  • Concurrent development of conditioned place preference and object aversion in place-object compound conditioning with methamphetamine US: Implications for opponent-process theories of drug conditioning

    神前裕

    Neuroscience 2016 (SFN annual meeting) 

    Presentation date: 2016.11

  • 事象間の随伴性判断と意図的行動の機構について

    神前裕  [Invited]

    北海道大学CERSSワークショップ 

    Presentation date: 2016.11

  • オペラント学習における連合過程とその神経基盤について

    神前裕  [Invited]

    第24回行動数理研究会(チュートリアル講演) 

    Presentation date: 2016.09

  • Towards an integrative understanding of cognitive and behavioural views of animal learning

    神前裕  [Invited]

    International Congress of Psychology (ICP) 2016 

    Presentation date: 2016.07

  • BTBR T+ tfマウスにおける連合学習の刺激選択的障害

    神前裕

    日本動物心理学会第161回例会 

    Presentation date: 2015.09

  • Conditioned social preference, but not place preference, produced by intranasal oxytocin in female mice

    神前裕

    The 75th Annual Meeting of the Japanese Society for Animal Psychology 

    Presentation date: 2015.09

  • The hippocampus and place learning revisited: potential interactions between multiple learning systems in the rat brain

    神前裕  [Invited]

    International symposium on the avian brains: another high function brain 

    Presentation date: 2015.08

  • Asymmetric generalisation of different lengths in the rat

    神前裕

    The 74th Annual Meeting of the Japanese Society for Animal Psychology 

    Presentation date: 2014.07

  • Navigation, association, and multiple learning systems in the brain

    神前裕  [Invited]

    The 140th Bio-Psycho Symposium 

    Presentation date: 2014.05

  • Asymmetry in the discrimination of length during spatial learning

    神前裕

    The 17th Associative Learning Symposium (Gregynog) 

    Presentation date: 2013.04

  • Lesions of the dorsolateral striatum impair spatial learning based on the landmark-goal vector but facilitate cognitive mapping in the rat

    神前裕

    The 43rd Meeting of the European Brain and Behavior Society (EBBS) 

    Presentation date: 2011.09

  • Overshadowing and potentiation of geometry learning by discrete landmarks in the watermaze: the effect of stimulus salience

    神前裕

    14th Associative learning symposium (Gregynog) 

    Presentation date: 2010.03

  • The role of choice and contingency in development of behavioural autonomy

    神前裕

    13th Associative learning symposium (Gregynog) 

    Presentation date: 2009.04

  • Contextual control of habit formation with multiple reinforcers

    神前裕

    11th Associative learning symposium (Gregynog) 

    Presentation date: 2007.03

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Research Projects

  • Elucidating the roles of contextual stimuli in the formation of habit and addiction

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2022.04
    -
    2025.03
     

  • 慢性的飲酒が行動の習慣制御と代替行動分化強化法の有効性に及ぼす影響の検証

    お酒の科学財団 

    Project Year :

    2023.04
    -
    2025.03
     

    神前裕

  • Associative and neural mechanisms underlying extinction of voluntary behaviour

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2019.04
    -
    2022.03
     

    Kosaki Yutaka

     View Summary

    The current project focused on the extinction of learned behaviour, and more specifically potential changes in the associative structure controlling instrumental behaviour during extinction learning. The results from individual experiments in the current project offered some new insight into this issue. First, the renewal of extinguished behaviour turned out to be a result of hierarchical control exerted by contextual stimuli, and not resulted from associative competition between instrumental behaviour and contextual stimuli as envisaged by Rescorla-Wagner (1972) model (i.e., protection from extinction). Second, the associative structure underlying instrumental behaviour, whether S-R habit process or R-O goal-directed process, did not change when the behaviour re-emerged after extinction; both types of behaviour showed renewal effect while maintaining their original associative status.

  • Microscopic theory underlying the transition from goal-directed to habitual behavior and its application to dependence research

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2018.04
    -
    2021.03
     

    Sawa Kosuke

     View Summary

    It is well known that goal-directed behavior, which is performed with the goal of predicting the outcome of one's own behavior, can change into habitual behavior, which is strongly controlled by the stimulus environment rather than the behavioral outcome, with extensive training. The results of the present studies indicated that these results are not necessarily robust, and that it is necessary to take into account the effects of not only the number of training sessions and the types of outcome, but also the stimuli comprising the experimental context.

  • Neural and pharmacological mechanism of drug addiction through negative reinforcement

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2018
    -
    2021
     

    Kosaki Yutaka

     View Summary

    The current research project explored learning processes that contribute to drug addiction, with a particular focus on the process of negative reinforcement. From the results of individual experiments using rats and mice, it has been demonstrated that drugs of abuse disrupt normal decision making, and that repeated exposures to methamphetamine come to elicit context-dependent ultra sonic vocalisations (USVs). The conditioned USVs could serve as a convenient behavioural measure to capture the development of compensatory response to drug-paired cue, which has been given theoretical importance in the account of drug addiction through negative reinforcement process. Furthermore, the results also offered important insights into how once-extinguished instrumental behaviour re-emerge after contextual change. Overall, the current research project gave rise to a set of important empirical findings which could advance our understanding of drug addiction.

  • Neuropsycopharmacological investigation on animal learning based on contiguity or contingency between events

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2016.04
    -
    2019.03
     

    Kosaki Yutaka

     View Summary

    Animals, including humans, learn about relationships between multiple events in the environment or between their own behaviour and external events, through at least two distinct learning processes; contiguity-based learning and contingency-based learning processes. The two processes are thought to rely on dissociable neural circuits. The current project sought to reveal fundamental variables that brings about the formation of each type of learning, using mice as subjects. Chronic pre-exposure to methamphetamine disrupted animals' sensitivity to the instrumental contingency between behaviour and its outcome. In a modified version of conditioned place preference task, a form of Pavlovian conditioning task, pairing a compound CS with methamphetamine US did not result in overshadowing, thereby showing a disruption of contingency-based learning. Together the results suggest hat the drug of abuse, such as methamphetamine, promote learning based simply on the contiguity between events.

  • On the role of the anterior cingulate cortex in goal-directed instrumental behaviour in rats

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2014.08
    -
    2016.03
     

    Kosaki Yutaka

     View Summary

    Instrumental behaviour of animals, including humans, is theorised to be mediated by two distinct processes. One is a process where a stimulus-response (S-R) association reinforced by the outcome of the response. The other is a goal-directed process, in which animals are sensitive to the contingency between response and its outcome as well as to the expected value of the outcome. In the current study, I examined the contribution of the peri-genual anterior cingulate cortex (ACC) to these distinct processes underlying instrumental behaviour. Using the contingency-degradation procedure and the outcome devaluation procedure, I found that the rats with ibotenic acid-induced lesions of the ACC performed comparably to the sham-lesioned control animals, in either of these tests. The results suggest that the peri-genual ACC, in contrast to the more anterior prelimbic cortex, is not crucial for the goal-directed control of instrumental behaviour.

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Misc

  • IP005 レバー位置弁別の連続獲得におけるラット海馬 : 内側前頭前野系の役割

    神前 裕, 渡辺 茂

    動物心理学研究   53 ( 2 ) 102 - 102  2003.12

    CiNii

  • Effects of intra-accumbens and intra-prefrontal cortex injection of haloperidol on the acquisition and the expression of methamphetamine-induced conditioned place preference

    KOSAKI Yutaka, IKEDA Motoko, WATANABE Shigeru

      22 ( 6 ) 276 - 276  2002.12

    CiNii

  • P-2-4 空間弁別学習の反復獲得課題におけるラット内側前頭前野,帯状皮質吻側部,および帯状皮質尾側部損傷の効果

    神前 裕, 渡辺 茂

    動物心理学研究   52 ( 2 ) 154 - 154  2002.12

    CiNii

 

Syllabus

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Teaching Experience

  • 心理学概論

    早稲田大学  

  • 心理学演習(実習)

    早稲田大学  

  • 学習心理学実験

    早稲田大学  

  • フィールド実習

    早稲田大学  

  • 学習心理学

    早稲田大学  

  • 神経科学特殊IV: 情動と学習の神経科学

    慶應義塾大学  

  • Psychological Measurement and Evaluation (in English)

    国際基督教大学(ICU)  

  • Biological Basis of Mind and Behaviour (in English)

    国際基督教大学(ICU)  

  • 生理と心理(生理心理学入門)

    昭和女子大学  

  • 生理心理学

    昭和女子大学  

  • 学習と記憶

    国立障害者リハビリテーションセンター学院  

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Internal Special Research Projects

  • ラットを用いた依存形成の行動メカニズムについての実験的検討

    2018  

     View Summary

    薬物やギャンブルへの依存の行動メカニズムを検証するためラット・マウスを用いて実験を行なった。実験1では、レバー押し行動と報酬との間の随伴性を変化させた際に、覚せい剤を慢性事前投与された群では随伴性追従の程度が低下することを示した。実験2では、マウスを用いて覚せい剤またはニコチンの投与がギャンブル用行動に与える影響をオペラント課題において検証した。反応に対して報酬が一定の割合で与えられる選択肢よりも、反応に対して変動する割合で報酬が与えられる選択肢に対する選好がニコチン投与により増加することが確認された。本研究課題により、依存形成のメカニズム解明に向けて重要なデータを得ることができた。

  • 自閉症モデル系統マウスにおける随意行動と結果との随伴性に対する感受性の検討

    2017  

     View Summary

    自閉症スペクトラム障害の基礎的メカニズムとして、事象間の随伴性判断に障害が見られるか、マウスモデルを用いて検討した。道具的条件づけ手続きを用い、レバー押し行動と餌報酬との間の随伴性を操作し、随伴性操作に対する行動の感受性を自閉症モデル系統のBTBT T+/tfマウスと標準的なC57BL/6マウスにて比較した。実験1・2において、異なる種類の強化子を用いてレバー押しを訓練したが、いずれにおいても、 C57系統に比べ、BTBR系統では 訓練に用いた間欠強化スケジュールでの要求反応比率を上昇させると反応が維持されなくなり、安定した反応率を維持する事が出来なかった。実験3ではFR3での最小限の訓練後、強化子低価値化手続きを用いて、行動に伴う結果表象の有無を検証した。BTBR系統では低価値化の効果が傾向として認められたが、統制群であるC57系統で低価値化効果が見られなかった。いずれの実験においても、実験手続きの更なる改良が必要であることが明らかになった。