KOSAKI, Yutaka

写真a

Affiliation

Faculty of Letters, Arts and Sciences, School of Humanities and Social Sciences

Job title

Associate Professor

Homepage URL

http://researchers.waseda.jp/profile/ja.f9878aeddcf167b1b90d7067a4738929.html

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Education 【 display / non-display 】

  • 　
    -
    2008.11

    University of Cambridge (PhD)   Department of Experimental Psychology  

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Degree 【 display / non-display 】

  • University of Cambridge   PhD

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Research Experience 【 display / non-display 】

  • 2017.04
    -
    Now

    Waseda University   Department of Psychology, School of Humanities and Social Sciences   Associate Professor

  • 2015.12
    -
    2017.03

    Keio University   Advanced Research Centers   Assistant Professor

  • 2014.04
    -
    2015.11

    Keio University   Advanced Research Centers   Research Associate

  • 2011.11
    -
    2014.03

    Cardiff University   School of Psychology   Research Associate

  • 2008.11
    -
    2011.10

    Durham University   Department of Psychology   Research Associate

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Professional Memberships 【 display / non-display 】

  • 　
    　
    　

    THE JAPAN NEUROSCIENCE SOCIETY

  • 　
    　
    　

    JAPANESE SOCIETY FOR ANIMAL PSYCHOLOGY

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Research Areas 【 display / non-display 】

  • Experimental psychology   Associative learning theory

  • Neuroscience-general   Behavioural Neuroscience

  • Neuroscience-general   Behavioural Neuroscience

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Research Interests 【 display / non-display 】

  • Pavlovian conditioning

  • Instrumental conditioning

  • Spatial learning

  • Multiple memory systems

  • Stimulus-response habit

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Papers 【 display / non-display 】

  • Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions

    Steven L. Poulter, Yutaka Kosaki, David J. Sanderson, Anthony McGregor

    Brain and Neuroscience Advances ( SAGE Publications )  4   239821282097259 - 239821282097259  2020.11  [Refereed]

    　View Summary

    We examined the role of the hippocampus and the dorsolateral striatum in the representation of environmental geometry using a spontaneous object recognition procedure. Rats were placed in a kite-shaped arena and allowed to explore two distinctive objects in each of the right-angled corners. In a different room, rats were then placed into a rectangular arena with two identical copies of one of the two objects from the exploration phase, one in each of the two adjacent right-angled corners that were separated by a long wall. Time spent exploring these two objects was recorded as a measure of recognition memory. Since both objects were in different locations with respect to the room (different between exploration and test phases) and the global geometry (also different between exploration and test phases), differential exploration of the objects must be a result of initial habituation to the object relative to its local geometric context. The results indicated an impairment in processing the local geometric features of the environment for both hippocampus and dorsolateral striatum lesioned rats compared with sham-operated controls, though a control experiment showed these rats were unimpaired in a standard object recognition task. The dorsolateral striatum has previously been implicated in egocentric route-learning, but the results indicate an unexpected role for the dorsolateral striatum in processing the spatial layout of the environment. The results provide the first evidence that lesions to the hippocampus and dorsolateral striatum impair spontaneous encoding of local environmental geometric features.

    DOI

  • Spatial inference without a cognitive map: the role of higher‐order path integration

    Youcef Bouchekioua, Aaron P. Blaisdell, Yutaka Kosaki, Iku Tsutsui‐Kimura, Paul Craddock, Masaru Mimura, Shigeru Watanabe

    Biological Reviews ( Wiley )   2020.09  [Refereed]

    DOI

  • En route to delineating hippocampal roles in spatial learning.

    Poulter, S, Austen, J. M, Kosaki, Y, Dachtler, J, Lever, C, McGregor, A

    Behavioural Brain Research   369 ( online first publication )  2019  [Refereed]

  • The response strategy and the place strategy in a plus-maze have different sensitivities to devaluation of expected outcome

    Yutaka Kosaki, John M. Pearce, Anthony McGregor

    Hippocampus ( John Wiley and Sons Inc. )  28 ( 7 ) 484 - 496  2018.07  [Refereed]

    　View Summary

    Previous studies have suggested that spatial navigation can be achieved with at least two distinct learning processes, involving either cognitive map-like representations of the local environment, referred to as the “place strategy”, or simple stimulus-response (S-R) associations, the “response strategy”. A similar distinction between cognitive/behavioral processes has been made in the context of non-spatial, instrumental conditioning, with the definition of two processes concerning the sensitivity of a given behavior to the expected value of its outcome as well as to the response-outcome contingency (“goal-directed action” and “S-R habit”). Here we investigated whether these two versions of dichotomist definitions of learned behavior, one spatial and the other non-spatial, correspond to each other in a formal way. Specifically, we assessed the goal-directed nature of two navigational strategies, using a combination of an outcome devaluation procedure and a spatial probe trial frequently used to dissociate the two navigational strategies. In Experiment 1, rats trained in a dual-solution T-maze task were subjected to an extinction probe trial from the opposite start arm, with or without prefeeding-induced devaluation of the expected outcome. We found that a non-significant preference for the place strategy in the non-devalued condition was completely reversed after devaluation, such that significantly more animals displayed the use of the response strategy. The result suggests that the place strategy is sensitive to the expected value of the outcome, while the response strategy is not. In Experiment 2, rats with hippocampal lesions showed significant reliance on the response strategy, regardless of whether the expected outcome was devalued or not. The result thus offers further evidence that the response strategy conforms to the definition of an outcome-insensitive, habitual form of instrumental behavior. These results together attest a formal correspondence between two types of dual-process accounts of animal learning and behavior.

    DOI

  • Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

    Youcef Bouchekioua, Iku Tsutsui-Kimura, Hiromi Sano, Miwako Koizumi, Kenji F. Tanaka, Keitaro Yoshida, Yutaka Kosaki, Shigeru Watanabe, Masaru Mimura

    Neuroscience Research ( Elsevier Ireland Ltd )  132   53 - 57  2018.07  [Refereed]

    　View Summary

    Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

    DOI

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Books and Other Publications 【 display / non-display 】

  • Evolutionary Origin of Empathy and Inequality Aversion. In S. Watanabe, M. Hofman, & T. Shimizu (Eds.), Evolution of the Brain, Cognition, and Emotion in Vertebrates

    Shigeru Watanabe, Yutaka Kosaki( Part： Contributor, pp. 273-299)

    Springer, Tokyo  2017

  • Cognitive functions of the medial prefrontal cortex in rats. In S. Watanabe (Ed.), Comparative Analysis of Mind.

    Yutaka Kosaki( Part： Contributor, Chapter 4. (pp. 73-98))

    Keio University Press (Tokyo)  2004

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Misc 【 display / non-display 】

  • IP005 レバー位置弁別の連続獲得におけるラット海馬 : 内側前頭前野系の役割

    神前 裕, 渡辺 茂

    動物心理学研究 ( 日本動物心理学会 )  53 ( 2 )  2003.12

    CiNii

  • P-2-4 空間弁別学習の反復獲得課題におけるラット内側前頭前野,帯状皮質吻側部,および帯状皮質尾側部損傷の効果

    神前 裕, 渡辺 茂

    動物心理学研究 ( 日本動物心理学会 )  52 ( 2 )  2002.12

    CiNii

  • Effects of intra-accumbens and intra-prefrontal cortex injection of haloperidol on the acquisition and the expression of methamphetamine-induced conditioned place preference

    KOSAKI Yutaka, IKEDA Motoko, WATANABE Shigeru

    日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology   22 ( 6 )  2002.12

    CiNii

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Awards 【 display / non-display 】

  • 印東太郎賞

    2018  

    Winner： 神前裕

  • 早稲田リサーチアワード（国際研究発信力）

    2018  

    Winner： 神前裕

  • 日本基礎心理学会優秀論文賞

    2016  

    Winner： 藤巻峻, 新保彰大, 松井大, 時暁聴, 神前裕

  • 中島記念国際交流財団 日本人留学生奨学金

    2004  

    Winner： 神前裕

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Research Projects 【 display / non-display 】

  • 随意行動の消去に関する連合学習およびシステム神経科学的検証

    Project Year :

    2019
    -
    2021
     

    神前裕

    Authorship： Principal investigator

  • 負の強化メカニズムを通じた薬物依存形成の行動神経薬理学的検討

    Project Year :

    2018
    -
    2021
     

    神前裕

    Authorship： Principal investigator

  • 目的的行動から習慣行動への遷移を支える微視的理論と依存研究への応用

    Project Year :

    2018
    -
    2021
     

    澤幸祐

  • Behaviuoral and neuropharmacological mechanisms underlying learning based on contiguity and contingency between events

    Project Year :

    2016.04
    -
    2019.03
     

    Yutaka Kosaki

    Authorship： Principal investigator

  • Role of the anterior cingulate cortex in goal-directed behaviour in rats

    Project Year :

    2014.08
    -
    2016.03
     

    Yutaka Kosaki

    Authorship： Principal investigator

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Presentations 【 display / non-display 】

  • What we talk about when we talk about conditioning

    神前裕  [Invited]

    第5回 印東太郎賞 受賞記念講演 

    Presentation date： 2018.10

  • 薬物依存と連合過程の変容について

    神前裕  [Invited]

    薬物・精神・行動の会 

    Presentation date： 2018.10

  • マウスにおける薬物条件づけ：メタンフェタミンをUSとした複合条件づけにおける場所選好と匂い嫌悪の並立獲得

    神前裕  [Invited]

    日本心理学会第82回大会 

    Presentation date： 2018.09

  • メタンフェタミンをUSとした複合条件づにおいて同時に獲得される場所選好と匂い嫌悪: 薬物依存の心理学的プロセスに対する考察

    神前裕  [Invited]

    平成30年度 アルコール・薬物依存関連学会合同学術総会 

    Presentation date： 2018.09

  • 空間的学習と非空間的学習の接点：学習理論の一般性について

    神前裕  [Invited]

    第23回CAPS研究会（関西学院大学） 

    Presentation date： 2018.01

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Specific Research 【 display / non-display 】

  • ラットを用いた依存形成の行動メカニズムについての実験的検討

    2018  

    　View Summary

    薬物やギャンブルへの依存の行動メカニズムを検証するためラット・マウスを用いて実験を行なった。実験１では、レバー押し行動と報酬との間の随伴性を変化させた際に、覚せい剤を慢性事前投与された群では随伴性追従の程度が低下することを示した。実験２では、マウスを用いて覚せい剤またはニコチンの投与がギャンブル用行動に与える影響をオペラント課題において検証した。反応に対して報酬が一定の割合で与えられる選択肢よりも、反応に対して変動する割合で報酬が与えられる選択肢に対する選好がニコチン投与により増加することが確認された。本研究課題により、依存形成のメカニズム解明に向けて重要なデータを得ることができた。

  • 自閉症モデル系統マウスにおける随意行動と結果との随伴性に対する感受性の検討

    2017  

    　View Summary

    自閉症スペクトラム障害の基礎的メカニズムとして、事象間の随伴性判断に障害が見られるか、マウスモデルを用いて検討した。道具的条件づけ手続きを用い、レバー押し行動と餌報酬との間の随伴性を操作し、随伴性操作に対する行動の感受性を自閉症モデル系統のBTBT T+/tfマウスと標準的なC57BL/6マウスにて比較した。実験1・2において、異なる種類の強化子を用いてレバー押しを訓練したが、いずれにおいても、 C57系統に比べ、BTBR系統では 訓練に用いた間欠強化スケジュールでの要求反応比率を上昇させると反応が維持されなくなり、安定した反応率を維持する事が出来なかった。実験3ではFR3での最小限の訓練後、強化子低価値化手続きを用いて、行動に伴う結果表象の有無を検証した。BTBR系統では低価値化の効果が傾向として認められたが、統制群であるC57系統で低価値化効果が見られなかった。いずれの実験においても、実験手続きの更なる改良が必要であることが明らかになった。

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Syllabus 【 display / non-display 】

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Teaching Experience 【 display / non-display 】

  • 心理学演習（実習）

    早稲田大学  

  • 学習心理学

    早稲田大学  

  • 学習と記憶

    国立障害者リハビリテーションセンター学院  

  • Biological Basis of Mind and Behaviour (in English)

    国際基督教大学（ICU)  

  • 心理学概論

    早稲田大学  

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Committee Memberships 【 display / non-display 】

  • 2017
    -
    Now

    日本動物心理学会  「動物心理学研究」編集幹事

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