Updated on 2024/02/28

写真a

 
TANAKA, Daiki
 
Affiliation
Research Council (Research Organization), Research Organization for Nano & Life Innovation
Job title
Junior Researcher(Assistant Professor)
Degree
博士

Research Experience

  • 2019.04
    -
    Now

    Waseda University   Research Organization for Nano & Life Innovation

  • 2015.04
    -
    2019.03

    Waseda University   Research Organization for Nano & Life Innovation

Education Background

  •  
    -
    2018.03

    Waseda University   Graduate School of Advanced Science and Engineering  

  •  
    -
    2014.03

    Tokyo University of Science   Faculty of Science, Division 2   Chemistry  

Research Areas

  • Inorganic/coordination chemistry / Measurement engineering / Nano/micro-systems

Research Interests

  • 微小計測工学

  • 合成化学

  • マイクロ・ナノ化学

  • 機能性材料合成

  • 微細加工技術

Awards

  • 第12回新化学技術研究奨励賞2023

    2023.06   公益社団法人新化学技術促進協会   ナノスケールで発現する特異的な化学反応解析デバイスの開発

    Winner: 田中 大器

  • 2019 Micromachines Best Paper Award

    2019.02   Micromachines   Size-Dependent and Property-Independent Passive Microdroplet Sorting by Droplet Transfer on Dot Rails

    Winner: D.H. Yoon, D. Tanaka, T. Sekiguchi, S. Shoji

 

Papers

  • High-Efficiency Single-Cell Containment Microdevices Based on Fluid Control

    Daiki Tanaka, Junichi Ishihara, Hiroki Takahashi, Masashi Kobayashi, Aya Miyazaki, Satsuki Kajiya, Risa Fujita, Naoki Maekawa, Yuriko Yamazaki, Akiko Takaya, Yuumi Nakamura, Masahiro Furuya, Tetsushi Sekiguchi, Shuichi Shoji

    Micromachines   14 ( 5 ) 1027 - 1027  2023.05  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    In this study, we developed a comb-shaped microfluidic device that can efficiently trap and culture a single cell (bacterium). Conventional culture devices have difficulty in trapping a single bacterium and often use a centrifuge to push the bacterium into the channel. The device developed in this study can store bacteria in almost all growth channels using the flowing fluid. In addition, chemical replacement can be performed in a few seconds, making this device suitable for culture experiments with resistant bacteria. The storage efficiency of microbeads that mimic bacteria was significantly improved from 0.2% to 84%. We used simulations to investigate the pressure loss in the growth channel. The pressure in the growth channel of the conventional device was more than 1400 PaG, whereas that of the new device was less than 400 PaG. Our microfluidic device was easily fabricated by a soft microelectromechanical systems method. The device was highly versatile and can be applied to various bacteria, such as Salmonella enterica serovar Typhimurium and Staphylococcus aureus.

    DOI

    Scopus

  • Efficient Synthesis of a Schiff Base Copper(II) Complex Using a Microfluidic Device

    Masashi Kobayashi, Takashiro Akitsu, Masahiro Furuya, Tetsushi Sekiguchi, Shuichi Shoji, Takashi Tanii, Daiki Tanaka

    Micromachines   14 ( 4 ) 890 - 890  2023.04  [Refereed]

    Authorship:Last author

     View Summary

    The efficient synthesis of amino acid Schiff base copper(II) complexes using a microfluidic device was successfully achieved. Schiff bases and their complexes are remarkable compounds due to their high biological activity and catalytic function. Conventionally, products are synthesized under reaction conditions of 40 °C for 4 h using a beaker-based method. However, in this paper, we propose using a microfluidic channel to enable quasi-instantaneous synthesis at room temperature (23 °C). The products were characterized using UV–Vis, FT–IR, and MS spectroscopy. The efficient generation of compounds using microfluidic channels has the potential to significantly contribute to the efficiency of drug discovery and material development due to high reactivity.

    DOI

    Scopus

    3
    Citation
    (Scopus)
  • Efficient Generation of Microdroplets Using Tail Breakup Induced with Multi-Branch Channels

    Daiki Tanaka, Satsuki Kajiya, Seito Shijo, Dong Hyun Yoon, Masahiro Furuya, Yoshito Nozaki, Hiroyuki Fujita, Tetsushi Sekiguchi, Shuichi Shoji

    Molecules   26 ( 12 ) 3707 - 3707  2021.06  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    In recent years, research on the application of microdroplets in the fields of biotechnology and chemistry has made remarkable progress, but the technology for the stable generation of single-micrometer-scale microdroplets has not yet been established. In this paper, we developed an efficient and stable single-micrometer-scale droplet generation device based on the fragmentation of droplet tails, called “tail thread mode”, that appears under moderate flow conditions. This method can efficiently encapsulate microbeads that mimic cells and chemical products in passively generated single-micrometer-scale microdroplets. The device has a simple 2D structure; a T-junction is used for droplet generation; and in the downstream, multi-branch channels are designed for droplet deformation into the tail. Several 1–2 µm droplets were successfully produced by the tail’s fragmentation; this continuous splitting was induced by the branch channels. We examined a wide range of experimental conditions and found the optimal flow rate condition can be reduced to one-tenth compared to the conventional tip-streaming method. A mold was fabricated by simple soft lithography, and a polydimethylsiloxane (PDMS) device was fabricated using the mold. Based on the 15 patterns of experimental conditions and the results, the key factors for the generation of microdroplets in this device were examined. In the most efficient condition, 61.1% of the total droplets generated were smaller than 2 μm.

    DOI

    Scopus

  • Microdroplet synthesis of azo compounds with simple microfluidics-based pH control

    Daiki Tanaka, Shunsuke Sawai, Shohei Hattori, Yoshito Nozaki, Dong Hyun Yoon, Hiroyuki Fujita, Tetsushi Sekiguchi, Takashiro Akitsu, Shuichi Shoji

    RSC Advances   10 ( 64 ) 38900 - 38905  2020  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    <p>Conventional solution-phase synthesis of azo compounds is complicated by the need for precise pH and temperature control, high concentrations of pH control reagents, and by-product removal. The microdroplet synthesis method has solved these problems.</p>

    DOI

    Scopus

    12
    Citation
    (Scopus)
  • Deformability-Based Microfluidic Microdroplet Screening to Obtain Agarolytic Bacterial Cells

    Mikihisa Muta, Wataru Kawakubo, Dong Hyun Yoon, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji, Mei Ito, Yuji Hatada, Takashi Funatsu, Ryo Iizuka

    Analytical Chemistry    2023.10

    DOI

    Scopus

  • Dielectrophoresis-Based Selective Droplet Extraction Microfluidic Device for Single-Cell Analysis

    Seito Shijo, Daiki Tanaka, Tetsushi Sekiguchi, Jun-ichi Ishihara, Hiroki Takahashi, Masashi Kobayashi, Shuichi Shoji

    Micromachines   14 ( 3 ) 706 - 706  2023.03  [Refereed]

     View Summary

    We developed a microfluidic device that enables selective droplet extraction from multiple droplet-trapping pockets based on dielectrophoresis. The device consists of a main microchannel, five droplet-trapping pockets with side channels, and drive electrode pairs appropriately located around the trapping pockets. Agarose droplets capable of encapsulating biological samples were successfully trapped in the trapping pockets due to the difference in flow resistance between the main and side channels. Target droplets were selectively extracted from the pockets by the dielectrophoretic force generated between the electrodes under an applied voltage of 500 V. During their extraction from the trapping pockets, the droplets and their contents were exposed to an electric field for 400–800 ms. To evaluate whether the applied voltage could potentially damage the biological samples, the growth rates of Escherichia coli cells in the droplets, with and without a voltage applied, were compared. No significant difference in the growth rate was observed. The developed device enables the screening of encapsulated single cells and the selective extraction of target droplets.

    DOI

    Scopus

  • STABLE GENERATION OF SINGLE- MICRON DROPLETS AND HIGHLY EFFICIENT ENCAPSULATION OF CELLS BY MULTI-BRANCH CHANNELS

    Seito Shijo, Daiki Tanaka, Masahiro Furuya, Tetsushi Sekiguchi, Shuichi Shoji

    2022 IEEE 35TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE (MEMS)   2022-January   900 - 903  2022

     View Summary

    We have developed an efficient, stable device for generating single-micrometer-scale (1-2 mu m) droplets based on the fragmentation of droplet tails by tailing. The device, created by a simple soft lithography process, induced continuous droplet fragmentation by branched channels under low-flow conditions (1-10 mu L/min). The flow rate and surfactant concentration were also important factors for droplet fragmentation. Examining 10 combinations of flow rate and surfactant concentration revealed the optimal conditions, which produced droplets less than 2 mu m in size at a generation rate of 61.1%. With this method, we efficiently encapsulated cell-mimicking microbeads into passively generated single-micrometer-scale microdroplets.

    DOI

    Scopus

  • Controlling Microdroplet Inner Rotation by Parallel Carrier Flow of Sesame and Silicone Oils

    Hibiki Yoshimura, Daiki Tanaka, Masahiro Furuya, Tetsushi Sekiguchi, Shuichi Shoji

    Micromachines   13 ( 1 ) 9 - 9  2021.12  [Refereed]

     View Summary

    We developed a method for passively controlling microdroplet rotation, including interior rotation, using a parallel flow comprising silicone and sesame oils. This device has a simple 2D structure with a straight channel and T-junctions fabricated from polydimethylsiloxane. A microdroplet that forms upstream moves into the sesame oil. Then, the largest flow velocity at the interface of the two oil layers applies a rotational force to the microdroplet. A microdroplet in the lower oil rotates clockwise while that in the upper oil rotates anti-clockwise. The rotational direction was controlled by a simple combination of sesame and silicone oils. Droplet interior flow was visualized by tracking microbeads inside the microdroplets. This study will contribute to the efficient creation of chiral molecules for pharmaceutical and materials development by controlling rotational direction and speed.

    DOI

    Scopus

  • 抗菌性物質・薬剤耐性 ATP依存型Lonプロテアーゼによるパーシスタンス制御機構(ATP-dependent Lon protease regulates awakening from ciprofloxacin-induced persistence)

    前川 尚輝, 板寺 健悟, 石原 潤一, 梶谷 颯希, 田中 大器, 関口 哲志, 庄子 習一, 石橋 正己, 高橋 弘喜, 高屋 明子

    日本細菌学雑誌   76 ( 1 ) 61 - 61  2021.02

  • Development of Microdroplet Generation Method for Organic Solvents Used in Chemical Synthesis

    Shohei Hattori, Chenghe Tang, Daiki Tanaka, Dong Hyun Yoon, Yoshito Nozaki, Hiroyuki Fujita, Takashiro Akitsu, Tetsushi Sekiguchi, Shuichi Shoji

    Molecules   25 ( 22 ) 5360 - 5360  2020.11  [Refereed]

     View Summary

    Recently, chemical operations with microfluidic devices, especially droplet-based operations, have attracted considerable attention because they can provide an isolated small-volume reaction field. However, analysis of these operations has been limited mostly to aqueous-phase reactions in water droplets due to device material restrictions. In this study, we have successfully demonstrated droplet formation of five common organic solvents frequently used in chemical synthesis by using a simple silicon/glass-based microfluidic device. When an immiscible liquid with surfactant was used as the continuous phase, the organic solvent formed droplets similar to water-in-oil droplets in the device. In contrast to conventional microfluidic devices composed of resins, which are susceptible to swelling in organic solvents, the developed microfluidic device did not undergo swelling owing to the high chemical resistance of the constituent materials. Therefore, the device has potential applications for various chemical reactions involving organic solvents. Furthermore, this droplet generation device enabled control of droplet size by adjusting the liquid flow rate. The droplet generation method proposed in this work will contribute to the study of organic reactions in microdroplets and will be useful for evaluating scaling effects in various chemical reactions.

    DOI

  • Integration of Horizontal and Vertical Microfluidic Modules for Core-Shell Droplet Generation and Chemical Application

    Dong Hyun Yoon, Yoshito Nozaki, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    Micromachines   10 ( 613 ) 613 - 613  2019.09  [Refereed]

     View Summary

    This paper presents a method for utilizing three-dimensional microfluidic channels fully to realize multiple functions in a single device. The final device structure was achieved by combining three independent modules that consisted of horizontal and vertical channels. The device allowed for the one-step generation of water-in-oil-in-water droplets without the need for partial treatment of the polydimethylsiloxane channel surface using separate modules for generating water-in-oil droplets on the horizontal plane and oil-in-water droplets on the vertical plane. The second vertically structured module provided an efficient flow for the generation of highly wettable liquid droplets, and tuning of the first horizontally structured module enabled different modes of inner-core encapsulation within the oil shell. The successful integration of the vertical and horizontal channels for core-shell droplet generation and the chemical synthesis of a metal complex within the droplets were evaluated. The proposed approach of integrating independent modules will expand and enhance the functions of microfluidic platforms.

    DOI

    Scopus

    5
    Citation
    (Scopus)
  • High-Efficiency Dibromination of Organic Compound in Microfluidic Channel of SI Pillar Array Directly Coated with Iron Catalys

    Takuo Sugaya, Daiki Tanaka, Dong Hyun Yoon, Yoshito Nozaki, Tetsushi Sekiguchi, Takashiro Akitsu, Shuichi Shoji

    2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems &amp; Eurosensors XXXIII (TRANSDUCERS &amp; EUROSENSORS XXXIII)    2019.06

    DOI

  • Size-Dependent and Property-Independent Passive Microdroplet Sorting by Droplet Transfer on Dot Rails

    D.H. Yoon, D. Tanaka, T. Sekiguchi, S. Shoji

    Micromachines   9 ( 10 )  2018.10  [Refereed]

    DOI

    Scopus

    8
    Citation
    (Scopus)
  • Structural Formation of Oil-in-Water (O/W) and Water-in-Oil-in-Water (W/O/W) Droplets in PDMS Device Using Protrusion Channel without Hydrophilic Surface Treatment

    D.H. Yoon, D. Tanaka, T. Sekiguchi, S. Shoji

    Micromachines   9 ( 9 )  2018.09  [Refereed]

    DOI

    Scopus

    12
    Citation
    (Scopus)
  • Stochastic expression of lactate dehydrogenase A induces Escherichia coli persister formation

    Naoki Yamamoto, Rino Isshiki, Yuto Kawai, Daiki Tanaka, Tetsushi Sekiguchi, Shinya Matsumoto, Satoshi Tsuneda

    Journal of Bioscience and Bioengineering   126 ( 1 ) 30 - 37  2018.07  [Refereed]

     View Summary

    Bacterial persisters are phenotypic variants that survive the treatment of lethal doses of growth-targeting antibiotics without mutations. Although the mechanism underlying persister formation has been studied for decades, how the persister phenotype is switched on and protects itself from antibiotics has been elusive. In this study, we focused on the lactate dehydrogenase gene (ldhA) that was upregulated in an Escherichia coli persister-enriched population. A survival rate assay using an ldhA-overexpressing strain showed that ldhA expression induced persister formation. To identify ldhA-mediated persister formation at the single-cell level, time-lapse microscopy with a microfluidic device was used. Stochastic ldhA expression was found to induce dormancy and tolerance against high-dose ampicillin treatment (500 μg/ml). To better understand the underlying mechanism, we investigated the relationship between ldhA-mediated persister formation and previously reported persister formation through aerobic metabolism repression. As a result, ldhA expression enhanced the proton motive force (PMF) and ATP synthesis. These findings suggest that ldhA-mediated persister formation pathway is different from previously reported persister formation via repression of aerobic metabolism.

    DOI

    Scopus

    10
    Citation
    (Scopus)
  • Mechanical Reinforcement of Low-Concentration Alginate Fibers by Microfluidic Embedding of Multiple Cores

    Dong Hyun Yoon, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    Macromolecular Materials and Engineering   303 ( 3 )  2018.03  [Refereed]

     View Summary

    This paper presents mechanically reinforced low-concentration alginate fibers by embedding inner cores of high-concentration alginate. 3D structures by stacking multiple polydimethylsiloxane (PDMS) layers allow the microfluidic formation and control of the isolated cores in the continuous flow. The alginate hydrogel fibers are simply spun, and the compartments, central core, surrounding cores, and outer shell layer are successfully verified. The results demonstrate the great potential for the development of complex fibrous materials, particularly for biological applications, which require specific morphology and composition of the fibers.

    DOI

    Scopus

    6
    Citation
    (Scopus)
  • Analysis of vinylidene fluoride-trifluoroethylene copolymer film for nonpolarized energy harvester

    Yuki Kamata, Tetsushi Sekiguchi, Takashi Nakajima, Toshio Sasaki, Yoon Dong-Hyun, Daiki Tanaka, Shuichi Shoji

    JAPANESE JOURNAL OF APPLIED PHYSICS   56 ( 7 )  2017.07  [Refereed]

     View Summary

    In this paper, an investigation of a vinylidene fluoride-trifluoroethylene (VDF/TrFE) copolymer film for use in a nonpolarized energy harvester is presented. The Fourier transform infrared spectroscopy and X-ray diffraction analysis of a nonpolarized VDF/TrFE copolymer film indicate that polymer crystallinity depends on film thickness. Furthermore, the growth of the polar structure (beta phase) is observed upon the reduction in the thickness. However, power generation does not exhibit a linear behavior because the generation capacity increases with the thickness. These results indicate that the film thickness for a nonpolarized harvester must be optimized to obtain the maximum output. (C) 2017 The Japan Society of Applied Physics

    DOI CiNii

    Scopus

    2
    Citation
    (Scopus)
  • Simple microfluidic formation of highly heterogeneous microfibers using a combination of sheath units

    D. H. Yoon, K. Kobayashi, D. Tanaka, T. Sekiguchi, S. Shoji

    LAB ON A CHIP   17 ( 8 ) 1481 - 1486  2017.04  [Refereed]

     View Summary

    This paper presents the formation of complex cross-sectional microfibers using three-dimensional microfluidic devices. The compartments and shapes of core and shell layers in the microfibers were independently controlled via three-dimensional fluidic channels fabricated by the combination of sheath units. The number of layers is easily expanded by the stacking of these units. Therefore, the highly heterogeneous microfibers of alginate hydrogel are obtained in polydimethylsiloxane structures. This widely expandable method has great potential for the development of functional and complex fiber-shaped materials.

    DOI

    Scopus

    11
    Citation
    (Scopus)
  • Synthesis of an azo-Mn(II) complex with mild pH control using a microfluidic device

    Daiki Tanaka, Shunsuke Sawai, Dong Hyun Yoon, Tetsushi Sekiguchi, Takashiro Akitsu, Shuichi Shoji

    RSC ADVANCES   7 ( 63 ) 39576 - 39582  2017  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    This study describes the synthesis of an azo-Mn(II) complex requiring an accurate pH control. The reaction conditions for the delicate azo-Mn(II) complex could be precisely controlled using a microfluidic device. The microfluidic method showed the following advantages over the conventional method: the concentration of the pH-control reagent was reduced (1/15), the reaction time was remarkably decreased from 4 h to less than 1 s, and the reaction temperature was lowered from 40 to 23 degrees C. Moreover, the microfluidic device suppressed the oxidation of the compound and did not require cooling to remove the heat of reaction. In addition, the conventional method uses harsh pH control, whereas the microfluidic device permits mild pH control.

    DOI

    Scopus

    9
    Citation
    (Scopus)
  • 3D Structures: Microfluidic Stamping on Sheath Flow (Small 24/2016)

    Dong Hyun Yoon, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    Small     3200  2016.06  [Refereed]

    DOI PubMed

  • Microfluidic Stamping on Sheath Flow

    Dong Hyun Yoon, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    SMALL   12 ( 24 ) 3224 - 3228  2016.06  [Refereed]

     View Summary

    A microfluidic stamping method to form functional shapes on a cross section in fiber-shaped flow is proposed. Microfluidic stamping and overstamping allow various cross sectional shapes on the 3D flow. The shapes can be controlled by a change in combination of structures and fluidic conditions which correspond to stamp type and stamping force.

    DOI PubMed

    Scopus

    8
    Citation
    (Scopus)
  • Microfluidic synthesis of chiral salen Mn(II) and Co(II) complexes containing lysozyme

    Daiki Tanaka, Wataru Kawakubo, Erika Tsuda, Yuya Mitsumoto, Dong Hyun Yoon, Tetsushi Sekiguchi, Takashiro Akitsu, Shuichi Shoji

    RSC ADVANCES   6 ( 85 ) 81862 - 81868  2016  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    Efficient microfluidic synthesis of chiral salen Mn(II) and Co(II) complexes containing lysozyme was achieved. The reaction conditions for the delicate protein were controlled precisely with a separation barrier in the microfluidic device. The microfluidic method has the following advantages over the conventional method: a remarkable reduction in the reaction time from 4.5 h to less than 1 s for the synthesis of Mn(II) and Co(II) complexes, a reduction in the reaction temperature from 40 to 23 degrees C, and no need for an N-2 atmosphere because all the reagents are isolated from the air. A three-fold yield improvement was achieved for Mn(II) and Co(II) complexes containing lysozyme compared with conventional synthesis.

    DOI

    Scopus

    10
    Citation
    (Scopus)
  • ALL-ROUND MICRO SHEATH FLOW FORMATION TO REALIZE COMPLEX CROSS SECTIONS BY SIMPLY STACKED PDMS STRUCTURES

    Dong Hyun Yoon, Lisa Ariyoshi, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    2016 IEEE 29TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS)   2016-February   141 - 144  2016  [Refereed]

     View Summary

    This research proposed a sheath flow formation method for complex 3D structure such as multi-core and multi-sheath using multi-stacked PDMS units. Cross sectional shape of the flow and the number of sheath layer were defined simply by combination of different PDMS units. The stacked PDMS units allowed independent fluid injection of different layers and the short sheath area realized low diffusion between each layer. Furthermore, the proposed 3D device fabrication method requires only one point alignment. The sheath flow formation method is useful for wide applications which require fiber materials of specific cross sectional shapes and layers.

    DOI

    Scopus

  • Fabrication Process of Fluidic Devices for Producing Fine Droplets Using a Focused Ion Beam System

    Y. Nozaki, T. Kanai, A. Matsuo, D. Tanaka, I. Yuito, T. Takeuchi, T. Sekiguchi, S. Shoji

    2016 IEEE 16TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO)     795 - 798  2016  [Refereed]

     View Summary

    We conducted an experiment on the fabrication of fluidic devices for producing fine droplets. In our proposed method, multiple channels were fabricated by using a focused ion beam (FIB) system. The minimum feature top width was found to be approximately 56 nm. When both the target width and depth of one channel were set to 500 nm, the resultant top width was 750-780 nm, the bottom width was 250-320 nm, and the depth was 560 nm, almost achieving the target size for the channel depth.

    DOI

    Scopus

  • High Yield Micro Fludic Synthesis of Metal Complex Containig Proteins

    D. Tanaka, D. H. Yoon, T. Sekiguchi, S. Shoji, T. Akitsu

    Proceedings of the 6th International Symposium on Microchemsitry and Microsystems (ISMM)     39 - 40  2014.07  [Refereed]

    DOI

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Presentations

  • SYNTHESIS AND ISOLATION OF METAL COMPLEX-CONTAINING PROTEINS BY SUPER WATER REPELLENT DOUBLY REENTRANT STRUCTURE UMBRELLA PILLAR ARRAY

    Daiki Tanaka, Masashi Kobayashi, Risa Fujita, Takashiro Akitsu, Takashi Tanii, Masahiro Furuya, Tetsushi Sekiguchi, Shuichi Shoji

    The 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2023) 

    Presentation date: 2023.10

    Event date:
    2023.10
     
     
  • DOUBLING ACCELERATION OF SYNTHESIS SPEED OF METAL COMPLEXES BY SCALE EFFECTS IN MICRODROPLETS

    Masashi Kobayashi, Tomoya Murashige, Takashiro Akitsu, Hiroyuki Fujita, Takashi Tanii, Masahiro Furuya, Testushi Sekiguchi, Shuichi Shoji, Risa Fujita, Daiki Tanaka

    The 27th International Conference on Miniaturized Systems for Chemistry and Life Science (µTAS 2023) 

    Presentation date: 2023.10

    Event date:
    2023.10
     
     
  • 流体コントロールを応用した高効率細菌培養デバイスの開発

    田中大器, 関口哲志, 庄子習一

    第39回「センサ・マイクロマシンと応用システム」シンポジウム 

    Presentation date: 2022.11

    Event date:
    2022.11
     
     
  • PDMS-PDMS接合を用いたマイクロ流体デバイスの作製プロセスの最適化とそれを応用したタンパク質の結晶化と取り出し

    宮崎彩, 田中大器, 関口哲志, 庄子習一

    第39回「センサ・マイクロマシンと応用システム」シンポジウム 

    Presentation date: 2022.11

    Event date:
    2022.11
     
     
  • 電気浸透流を応用した一細胞選択抽出 マイクロ流体デバイスの開発

    四條星斗, 田中大器, 関口哲志, 庄子習一

    第39回「センサ・マイクロマシンと応用システム」シンポジウム 

    Presentation date: 2022.11

    Event date:
    2022.11
     
     
  • トラップデバイスにおける気液及び液液混相流の対比

    山中康平, 古谷正裕, 田中大喬, 田中大器, 関口哲志, 庄子習一, 鷲尾方一

    第13回マイクロ・ナノ工学シンポジウム 

    Event date:
    2022.11
     
     
  • The Best Use of Wall Shear to Generate Massive Monodisperse Single-Micrometer Droplets in Microchannel

    Manabu Asahi, Masahiro Furuya, Hirotaka Tanaka, Tomoya Murashige, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    8th Japan-Korea Joint Seminar on Nuclear Thermal Hydraulics and Safety for Students and Young Researchers (NTHAS12 Joint Seminar) 

    Event date:
    2022.10
     
     
  • Physics of Droplets Coalescing Inside the Micro flow Devices

    Tomoya Murashige, Masahiro Furuya, Hirotaka Tanaka, Manabu Asahi, Kohei Yamanaka, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    8th Japan-Korea Joint Seminar on Nuclear Thermal Hydraulics and Safety for Students and Young Researchers (NTHAS12 Joint Seminar) 

    Event date:
    2022.10
     
     
  • Selective Chemical Products Separation from Organic Micro Droplets Using Surfactant Free Single Micron Droplet Generation

    Shengqi Zheng, Daiki Tanaka, Hiroyuki Fujita, Takashiro Akitsu, Tetsushi Sekiguchi, Shuichi Shoji

    The 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2022) 

    Presentation date: 2022.10

    Event date:
    2022.10
     
     
  • High Speed and Room Temperature Synthesis of Amino Acid Schiff Base Copper Complex Using Microfluidic Device

    Masahi Kobayashi, Daiki Tanaka, Takashiro Akitsu, Tetsushi Sekiguchi, Shuichi Shoji

    The 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2022) 

    Presentation date: 2022.10

    Event date:
    2022.10
     
     
  • Efficient Protein Crystallization and Damageless Extraction Flow Device Using Multi-Microdroplet Trapping Structure

    Aya Miyazaki, Daiki Tanaka, Tetsushi Sekiguchi, Masahiro Furuya, Shuichi Shoji

    The 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2022) 

    Presentation date: 2022.10

    Event date:
    2022.10
     
     
  • マイクロドロップレットを応用してアミノ酸銅錯体の合成

    羽島颯平, 田中大器, 藤田博之, 秋津貴城, 関口哲志, 庄子習一

    日本化学会 第102春季年会(2022) 

    Presentation date: 2022.03

    Event date:
    2022.03
     
     
  • マイクロ流体デバイスを用いた高効率なアミノ酸含有銅錯体の合成

    小林雅史, 庄子習一, 関口哲志, 田中大器, 秋津貴城

    日本化学会 第102春季年会(2022) 

    Presentation date: 2022.03

    Event date:
    2022.03
     
     
  • マイクロドロップレットトラップデバイスを用いたリゾチームの結晶化

    宮崎彩, 庄子習一, 関口哲志, 田中大器

    日本化学会 第102春季年会(2022) 

    Presentation date: 2022.03

    Event date:
    2022.03
     
     
  • Stable Generation of Single-Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels

    Seito Shijo, Daiki Tanaka, Masahiro Furuya, Tetsushi Sekiguchi, Shuichi Shoji

    The 35th International Conference on Micro Electro Mechanical Systems (MEMS 2022) 

    Presentation date: 2022.01

    Event date:
    2022.01
     
     
  • Microdroplet Inner Rotation Control by Parallel Carrier Flow of Different Oils, Sesame and Silicone

    H. Yoshimura, D. Tanaka, T. Sekiguchi, S. Shoji

    The 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2021) 

    Presentation date: 2021.10

  • ESTABLISHMENT OF LABO-IN-A-MICRODROPLET FOR AZO COMPOUND SYNTHESIS

    D. Tanaka, S. Sawai, T. Sugaya, Y. Nozaki, D. H. Yoon, T. Isano, H. Yamagata, H. Fujita, T. Sekiguchi, T. Akitsu, S. Shoji

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences 

    Presentation date: 2020.10

  • 化学合成への応用に向けた有機溶媒のマイクロドロップレット形成手法の構築

    湯成河, 服部翔平, 野崎義人, 尹棟鉉, 田中大器, 藤田博之, 秋津貴城, 関口哲志, 庄子習一

    日本化学会 第100春季年会 

    Presentation date: 2020.03

  • マイクロ・ナノ流体工学の光学・バイオ・化学への応用

    庄子習一, 桑江博之, 尹棟鉉, 田中大器, 関口哲志, 水野潤, 野崎義人, 笠原崇史, 秋津貴城  [Invited]

    電子情報通信学会 システムナノ技術に関する特別研究専門委員会(SNT)第3回研究会 

    Presentation date: 2020.01

  • High Efficient Synthesis of Functional Compounds by Microfluidic Device

    D. Tanaka, D. H. Yoon, Y. Nozaki, T. Sekiguchi, T. Akitsu, S. Shoji

    International Symposium iLIM4 

    Presentation date: 2019.10

  • CONSTRUCTION OF A WELL-OPERABLE CRYSTALLIZATION METHOD FOR CHEMICAL ANALYSIS APPLYING MICRODROPLET DEVICE

    S. Hattori, D. Tanaka, D. H. Yoon, T. Sekiguchi, Y. Nozaki, T. Akitsu, S. Shoji

    Presentation date: 2019.10

  • HIGH-EFFICIENCY DIBROMINATION OF ORGANIC COMPOUND IN MICROFLUIDIC CHANNEL OF SI PILLAR ARRAY DIRECTLY COATED WITH IRON CATALYST

    T. Sugaya, D. Tanaka, D. H. Yoon, Y. Nozaki, T. Sekiguchi, T. Akitsu, S. Shoji

    Transducers 2019 

    Presentation date: 2019.06

    Event date:
    2019.06
     
     
  • マイクロ流体デバイスによる高効率かつ安全なブロモ基付加操作

    川久保 渉, 田中 大器, 尹 棟鉉, 関口 哲志, 高橋 啓太, 秋津 貴城, 庄子 習一

    「センサ・マイクロマシンと応用システム」シンポジウム 

    Presentation date: 2017.10

  • 超撥水製二重凹型ピラーアレイデバイスによるZn(II)錯体含有リゾチームの結晶化

    田中 大器, 川久保 渉, 尹 棟鉉, 関口 哲志, 秋津 貴城, 庄子 習一

    「センサ・マイクロマシンと応用システム」シンポジウム 

    Presentation date: 2017.10

  • ETREMELY EFFICIENT AND NON-HAZARDOUS BROMO GROUP ADDITION REACTION USING SIMPLE MICROFLUDIC DEVICES

    W. Kawakubo, D. Tanaka, D. H. Yoon, T. Sekiguchi, K. Takahashi, T. Akitsu, S. Shoji

    THE 3RD CONFERENCE ON MICROFLUIDIC HANDLING SYSTEMS 

    Presentation date: 2017.10

  • CRYSTALLIZATION OF ZINC(II) COMPLEX CONTAINING LYSOZYME BY SUPER WATER REPELLENT DOUBLY REENTRANT STRUCTURE PILLAR ARRAY DEVICE

    Daiki Tanaka

    THE 3RD CONFERENCE ON MICROFLUIDIC HANDLING SYSTEMS 

    Presentation date: 2017.10

  • Growth heterogeneity in pure cultures of nitrifiers

    Rino Isshiki

    Fifth International Conference on Nitrification and Related Processes 

    Presentation date: 2017.07

  • Fabrication Process of Fluidic Devices for Producing Fine Droplets Using a Focused Ion Beam System

    Yoshito Nazaki

    Proceedings of the 16th International Conference on Nanotechnology 

    Presentation date: 2016.08

  • ALL-ROUND MICRO SHEATH FLOW FORMATION TO REALIZE COMPLEX CROSS SECTIONS BY SIMPLY STACKED PDMS STACKED PDMS STRUCTURES

    Dong Hyun Yoon

    MEMS 2016 

    Presentation date: 2016.01

  • HIGH EFFICIENT SYNTHESIS OF MANGANESE(II), COBALT(II) COMPLEXES CONTAINING LYSOZYME USING REACTION AREA SEPARATED MICRO FLUIDIC DEVICE

    Daiki Tanaka

    Transducers 2015 

    Presentation date: 2015.06

  • HIGH YIELD MICRO FLUIDIC SYNTHESIS OF METAL COMPLEX CONTAINING PROTEINS

    Daiki Tanaka

    The 6th International Symposium on Microchemistry and Microsystems 

    Presentation date: 2014.07

▼display all

Research Projects

  • ナノスケールで発現する特異的な化学反応の解明

    日本学術振興会 科学研究費助成事業 若手研究

    Project Year :

    2023.04
    -
    2025.03
     

  • 超微小反応場を応用したバイオ電池材料の創出

    国立研究開発法人 科学技術振興機構  戦略的創造研究推進事業 ACT-X (加速フェーズへの移行含む)

    Project Year :

    2021.10
    -
    2025.03
     

  • 化学合成・分析マイクロデバイスの開発

    国立研究開発法人 科学技術振興機構  早稲田大学PoC Fund Program・タイプS

    Project Year :

    2023.06
    -
    2024.03
     

Misc

  • 流体コントロールを応用した高効率細菌培養デバイスの開発—Development of Highly Efficient Bacteria Culturing Device Applying Fluid Control

    田中 大器, 宮崎 彩, 梶谷 颯希, 古谷 正裕, 関口 哲志, 庄子 習一, 石原 潤一, 高橋 弘喜, 前川 尚輝, 山崎 由里子, 高屋 明子, 松岡 悠美

    「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編]   39   4p  2022.11

 

Syllabus

 

Sub-affiliation

  • Faculty of Science and Engineering   Graduate School of Fundamental Science and Engineering