Updated on 2022/05/25

写真a

 
TANAKA, Daiki
 
Affiliation
Research Council (Research Organization), Research Organization for Nano & Life Innovation
Job title
Junior Researcher(Assistant Professor)

Concurrent Post

  • Faculty of Science and Engineering   Graduate School of Fundamental Science and Engineering

Education

  •  
    -
    2018.03

    Waseda University   Graduate School of Advanced Science and Engineering  

  •  
    -
    2014.03

    Tokyo University of Science   Faculty of Science, Division 2   Chemistry  

Degree

  • 博士

Research Experience

  • 2019.04
    -
    Now

    Waseda University   Research Organization for Nano & Life Innovation

  • 2015.04
    -
    2019.03

    Waseda University   Research Organization for Nano & Life Innovation

 

Research Areas

  • Nano/micro-systems

Research Interests

  • マイクロ・ナノ化学

  • 機能性材料合成

  • 微細加工技術

Research Seeds

Papers

  • Efficient Generation of Microdroplets Using Tail Breakup Induced with Multi-Branch Channels

    Daiki Tanaka, Satsuki Kajiya, Seito Shijo, Dong Hyun Yoon, Masahiro Furuya, Yoshito Nozaki, Hiroyuki Fujita, Tetsushi Sekiguchi, Shuichi Shoji

    Molecules   26 ( 12 ) 3707 - 3707  2021.06  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    In recent years, research on the application of microdroplets in the fields of biotechnology and chemistry has made remarkable progress, but the technology for the stable generation of single-micrometer-scale microdroplets has not yet been established. In this paper, we developed an efficient and stable single-micrometer-scale droplet generation device based on the fragmentation of droplet tails, called “tail thread mode”, that appears under moderate flow conditions. This method can efficiently encapsulate microbeads that mimic cells and chemical products in passively generated single-micrometer-scale microdroplets. The device has a simple 2D structure; a T-junction is used for droplet generation; and in the downstream, multi-branch channels are designed for droplet deformation into the tail. Several 1–2 µm droplets were successfully produced by the tail’s fragmentation; this continuous splitting was induced by the branch channels. We examined a wide range of experimental conditions and found the optimal flow rate condition can be reduced to one-tenth compared to the conventional tip-streaming method. A mold was fabricated by simple soft lithography, and a polydimethylsiloxane (PDMS) device was fabricated using the mold. Based on the 15 patterns of experimental conditions and the results, the key factors for the generation of microdroplets in this device were examined. In the most efficient condition, 61.1% of the total droplets generated were smaller than 2 μm.

    DOI

  • Microdroplet synthesis of azo compounds with simple microfluidics-based pH control

    Daiki Tanaka, Shunsuke Sawai, Shohei Hattori, Yoshito Nozaki, Dong Hyun Yoon, Hiroyuki Fujita, Tetsushi Sekiguchi, Takashiro Akitsu, Shuichi Shoji

    RSC Advances   10 ( 64 ) 38900 - 38905  2020  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    <p>Conventional solution-phase synthesis of azo compounds is complicated by the need for precise pH and temperature control, high concentrations of pH control reagents, and by-product removal. The microdroplet synthesis method has solved these problems.</p>

    DOI

  • Controlling Microdroplet Inner Rotation by Parallel Carrier Flow of Sesame and Silicone Oils

    Hibiki Yoshimura, Daiki Tanaka, Masahiro Furuya, Tetsushi Sekiguchi, Shuichi Shoji

    Micromachines   13 ( 1 ) 9 - 9  2021.12  [Refereed]

     View Summary

    We developed a method for passively controlling microdroplet rotation, including interior rotation, using a parallel flow comprising silicone and sesame oils. This device has a simple 2D structure with a straight channel and T-junctions fabricated from polydimethylsiloxane. A microdroplet that forms upstream moves into the sesame oil. Then, the largest flow velocity at the interface of the two oil layers applies a rotational force to the microdroplet. A microdroplet in the lower oil rotates clockwise while that in the upper oil rotates anti-clockwise. The rotational direction was controlled by a simple combination of sesame and silicone oils. Droplet interior flow was visualized by tracking microbeads inside the microdroplets. This study will contribute to the efficient creation of chiral molecules for pharmaceutical and materials development by controlling rotational direction and speed.

    DOI

  • Development of Microdroplet Generation Method for Organic Solvents Used in Chemical Synthesis

    Shohei Hattori, Chenghe Tang, Daiki Tanaka, Dong Hyun Yoon, Yoshito Nozaki, Hiroyuki Fujita, Takashiro Akitsu, Tetsushi Sekiguchi, Shuichi Shoji

    Molecules   25 ( 22 ) 5360 - 5360  2020.11  [Refereed]

     View Summary

    Recently, chemical operations with microfluidic devices, especially droplet-based operations, have attracted considerable attention because they can provide an isolated small-volume reaction field. However, analysis of these operations has been limited mostly to aqueous-phase reactions in water droplets due to device material restrictions. In this study, we have successfully demonstrated droplet formation of five common organic solvents frequently used in chemical synthesis by using a simple silicon/glass-based microfluidic device. When an immiscible liquid with surfactant was used as the continuous phase, the organic solvent formed droplets similar to water-in-oil droplets in the device. In contrast to conventional microfluidic devices composed of resins, which are susceptible to swelling in organic solvents, the developed microfluidic device did not undergo swelling owing to the high chemical resistance of the constituent materials. Therefore, the device has potential applications for various chemical reactions involving organic solvents. Furthermore, this droplet generation device enabled control of droplet size by adjusting the liquid flow rate. The droplet generation method proposed in this work will contribute to the study of organic reactions in microdroplets and will be useful for evaluating scaling effects in various chemical reactions.

    DOI

  • Integration of Horizontal and Vertical Microfluidic Modules for Core-Shell Droplet Generation and Chemical Application

    Dong Hyun Yoon, Yoshito Nozaki, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    Micromachines   10 ( 613 )  2019.09  [Refereed]

  • Size-Dependent and Property-Independent Passive Microdroplet Sorting by Droplet Transfer on Dot Rails

    D.H. Yoon, D. Tanaka, T. Sekiguchi, S. Shoji

    Micromachines   9 ( 10 )  2018.10  [Refereed]

    DOI

  • Structural Formation of Oil-in-Water (O/W) and Water-in-Oil-in-Water (W/O/W) Droplets in PDMS Device Using Protrusion Channel without Hydrophilic Surface Treatment

    D.H. Yoon, D. Tanaka, T. Sekiguchi, S. Shoji

    Micromachines   9 ( 9 )  2018.09  [Refereed]

    DOI

  • Mechanical Reinforcement of Low-Concentration Alginate Fibers by Microfluidic Embedding of Multiple Cores

    Dong Hyun Yoon, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    Macromolecular Materials and Engineering   303 ( 3 )  2018.03  [Refereed]

     View Summary

    This paper presents mechanically reinforced low-concentration alginate fibers by embedding inner cores of high-concentration alginate. 3D structures by stacking multiple polydimethylsiloxane (PDMS) layers allow the microfluidic formation and control of the isolated cores in the continuous flow. The alginate hydrogel fibers are simply spun, and the compartments, central core, surrounding cores, and outer shell layer are successfully verified. The results demonstrate the great potential for the development of complex fibrous materials, particularly for biological applications, which require specific morphology and composition of the fibers.

    DOI

  • Analysis of vinylidene fluoride-trifluoroethylene copolymer film for nonpolarized energy harvester

    Yuki Kamata, Tetsushi Sekiguchi, Takashi Nakajima, Toshio Sasaki, Yoon Dong-Hyun, Daiki Tanaka, Shuichi Shoji

    JAPANESE JOURNAL OF APPLIED PHYSICS   56 ( 7 )  2017.07  [Refereed]

     View Summary

    In this paper, an investigation of a vinylidene fluoride-trifluoroethylene (VDF/TrFE) copolymer film for use in a nonpolarized energy harvester is presented. The Fourier transform infrared spectroscopy and X-ray diffraction analysis of a nonpolarized VDF/TrFE copolymer film indicate that polymer crystallinity depends on film thickness. Furthermore, the growth of the polar structure (beta phase) is observed upon the reduction in the thickness. However, power generation does not exhibit a linear behavior because the generation capacity increases with the thickness. These results indicate that the film thickness for a nonpolarized harvester must be optimized to obtain the maximum output. (C) 2017 The Japan Society of Applied Physics

    DOI CiNii

  • Simple microfluidic formation of highly heterogeneous microfibers using a combination of sheath units

    D. H. Yoon, K. Kobayashi, D. Tanaka, T. Sekiguchi, S. Shoji

    LAB ON A CHIP   17 ( 8 ) 1481 - 1486  2017.04  [Refereed]

     View Summary

    This paper presents the formation of complex cross-sectional microfibers using three-dimensional microfluidic devices. The compartments and shapes of core and shell layers in the microfibers were independently controlled via three-dimensional fluidic channels fabricated by the combination of sheath units. The number of layers is easily expanded by the stacking of these units. Therefore, the highly heterogeneous microfibers of alginate hydrogel are obtained in polydimethylsiloxane structures. This widely expandable method has great potential for the development of functional and complex fiber-shaped materials.

    DOI

  • Synthesis of an azo-Mn(II) complex with mild pH control using a microfluidic device

    Daiki Tanaka, Shunsuke Sawai, Dong Hyun Yoon, Tetsushi Sekiguchi, Takashiro Akitsu, Shuichi Shoji

    RSC ADVANCES   7 ( 63 ) 39576 - 39582  2017  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    This study describes the synthesis of an azo-Mn(II) complex requiring an accurate pH control. The reaction conditions for the delicate azo-Mn(II) complex could be precisely controlled using a microfluidic device. The microfluidic method showed the following advantages over the conventional method: the concentration of the pH-control reagent was reduced (1/15), the reaction time was remarkably decreased from 4 h to less than 1 s, and the reaction temperature was lowered from 40 to 23 degrees C. Moreover, the microfluidic device suppressed the oxidation of the compound and did not require cooling to remove the heat of reaction. In addition, the conventional method uses harsh pH control, whereas the microfluidic device permits mild pH control.

    DOI

  • 3D Structures: Microfluidic Stamping on Sheath Flow (Small 24/2016)

    Dong Hyun Yoon, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    Small     3200  2016.06  [Refereed]

    DOI PubMed

  • Microfluidic Stamping on Sheath Flow

    Dong Hyun Yoon, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    SMALL   12 ( 24 ) 3224 - 3228  2016.06  [Refereed]

     View Summary

    A microfluidic stamping method to form functional shapes on a cross section in fiber-shaped flow is proposed. Microfluidic stamping and overstamping allow various cross sectional shapes on the 3D flow. The shapes can be controlled by a change in combination of structures and fluidic conditions which correspond to stamp type and stamping force.

    DOI PubMed

  • Microfluidic synthesis of chiral salen Mn(II) and Co(II) complexes containing lysozyme

    Daiki Tanaka, Wataru Kawakubo, Erika Tsuda, Yuya Mitsumoto, Dong Hyun Yoon, Tetsushi Sekiguchi, Takashiro Akitsu, Shuichi Shoji

    RSC ADVANCES   6 ( 85 ) 81862 - 81868  2016  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    Efficient microfluidic synthesis of chiral salen Mn(II) and Co(II) complexes containing lysozyme was achieved. The reaction conditions for the delicate protein were controlled precisely with a separation barrier in the microfluidic device. The microfluidic method has the following advantages over the conventional method: a remarkable reduction in the reaction time from 4.5 h to less than 1 s for the synthesis of Mn(II) and Co(II) complexes, a reduction in the reaction temperature from 40 to 23 degrees C, and no need for an N-2 atmosphere because all the reagents are isolated from the air. A three-fold yield improvement was achieved for Mn(II) and Co(II) complexes containing lysozyme compared with conventional synthesis.

    DOI

  • ALL-ROUND MICRO SHEATH FLOW FORMATION TO REALIZE COMPLEX CROSS SECTIONS BY SIMPLY STACKED PDMS STRUCTURES

    Dong Hyun Yoon, Lisa Ariyoshi, Daiki Tanaka, Tetsushi Sekiguchi, Shuichi Shoji

    2016 IEEE 29TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS)   2016-February   141 - 144  2016  [Refereed]

     View Summary

    This research proposed a sheath flow formation method for complex 3D structure such as multi-core and multi-sheath using multi-stacked PDMS units. Cross sectional shape of the flow and the number of sheath layer were defined simply by combination of different PDMS units. The stacked PDMS units allowed independent fluid injection of different layers and the short sheath area realized low diffusion between each layer. Furthermore, the proposed 3D device fabrication method requires only one point alignment. The sheath flow formation method is useful for wide applications which require fiber materials of specific cross sectional shapes and layers.

    DOI

  • Fabrication Process of Fluidic Devices for Producing Fine Droplets Using a Focused Ion Beam System

    Y. Nozaki, T. Kanai, A. Matsuo, D. Tanaka, I. Yuito, T. Takeuchi, T. Sekiguchi, S. Shoji

    2016 IEEE 16TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO)     795 - 798  2016  [Refereed]

     View Summary

    We conducted an experiment on the fabrication of fluidic devices for producing fine droplets. In our proposed method, multiple channels were fabricated by using a focused ion beam (FIB) system. The minimum feature top width was found to be approximately 56 nm. When both the target width and depth of one channel were set to 500 nm, the resultant top width was 750-780 nm, the bottom width was 250-320 nm, and the depth was 560 nm, almost achieving the target size for the channel depth.

    DOI

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Research Projects

  • 超微小反応場を応用したバイオ電池材料の創出

    科学技術振興機構  ACT-X

    Project Year :

    2021.10
    -
    2024.03
     

Presentations

  • ESTABLISHMENT OF LABO-IN-A-MICRODROPLET FOR AZO COMPOUND SYNTHESIS

    D. Tanaka, S. Sawai, T. Sugaya, Y. Nozaki, D. H. Yoon, T. Isano, H. Yamagata, H. Fujita, T. Sekiguchi, T. Akitsu, S. Shoji

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences 

    Presentation date: 2020.10

  • High Efficient Synthesis of Functional Compounds by Microfluidic Device

    D. Tanaka, D. H. Yoon, Y. Nozaki, T. Sekiguchi, T. Akitsu, S. Shoji

    International Symposium iLIM4 

    Presentation date: 2019.10

  • CONSTRUCTION OF A WELL-OPERABLE CRYSTALLIZATION METHOD FOR CHEMICAL ANALYSIS APPLYING MICRODROPLET DEVICE

    S. Hattori, D. Tanaka, D. H. Yoon, T. Sekiguchi, Y. Nozaki, T. Akitsu, S. Shoji

    Presentation date: 2019.10

  • HIGH-EFFICIENCY DIBROMINATION OF ORGANIC COMPOUND IN MICROFLUIDIC CHANNEL OF SI PILLAR ARRAY DIRECTLY COATED WITH IRON CATALYST

    T. Sugaya, D. Tanaka, D. H. Yoon, Y. Nozaki, T. Sekiguchi, T. Akitsu, S. Shoji

    Transducers 2019 

    Presentation date: 2019.06

    Event date:
    2019.06
     
     
  • マイクロ流体デバイスによる高効率かつ安全なブロモ基付加操作

    川久保 渉, 田中 大器, 尹 棟鉉, 関口 哲志, 高橋 啓太, 秋津 貴城, 庄子 習一

    「センサ・マイクロマシンと応用システム」シンポジウム 

    Presentation date: 2017.10

  • 超撥水製二重凹型ピラーアレイデバイスによるZn(II)錯体含有リゾチームの結晶化

    田中 大器, 川久保 渉, 尹 棟鉉, 関口 哲志, 秋津 貴城, 庄子 習一

    「センサ・マイクロマシンと応用システム」シンポジウム 

    Presentation date: 2017.10

  • ETREMELY EFFICIENT AND NON-HAZARDOUS BROMO GROUP ADDITION REACTION USING SIMPLE MICROFLUDIC DEVICES

    W. Kawakubo, D. Tanaka, D. H. Yoon, T. Sekiguchi, K. Takahashi, T. Akitsu, S. Shoji

    THE 3RD CONFERENCE ON MICROFLUIDIC HANDLING SYSTEMS 

    Presentation date: 2017.10

  • CRYSTALLIZATION OF ZINC(II) COMPLEX CONTAINING LYSOZYME BY SUPER WATER REPELLENT DOUBLY REENTRANT STRUCTURE PILLAR ARRAY DEVICE

    Daiki Tanaka

    THE 3RD CONFERENCE ON MICROFLUIDIC HANDLING SYSTEMS 

    Presentation date: 2017.10

  • Growth heterogeneity in pure cultures of nitrifiers

    Rino Isshiki

    Fifth International Conference on Nitrification and Related Processes 

    Presentation date: 2017.07

  • Fabrication Process of Fluidic Devices for Producing Fine Droplets Using a Focused Ion Beam System

    Yoshito Nazaki

    Proceedings of the 16th International Conference on Nanotechnology 

    Presentation date: 2016.08

  • ALL-ROUND MICRO SHEATH FLOW FORMATION TO REALIZE COMPLEX CROSS SECTIONS BY SIMPLY STACKED PDMS STACKED PDMS STRUCTURES

    Dong Hyun Yoon

    MEMS 2016 

    Presentation date: 2016.01

  • HIGH EFFICIENT SYNTHESIS OF MANGANESE(II), COBALT(II) COMPLEXES CONTAINING LYSOZYME USING REACTION AREA SEPARATED MICRO FLUIDIC DEVICE

    Daiki Tanaka

    Transducers 2015 

    Presentation date: 2015.06

  • HIGH YIELD MICRO FLUIDIC SYNTHESIS OF METAL COMPLEX CONTAINING PROTEINS

    Daiki Tanaka

    The 6th International Symposium on Microchemistry and Microsystems 

    Presentation date: 2014.07

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Syllabus

  • MEMS

    Graduate School of Fundamental Science and Engineering

    2022   spring semester

  • MEMS

    Graduate School of Advanced Science and Engineering

    2022   spring semester

  • MEMS

    School of Fundamental Science and Engineering

    2022   spring semester