YAGI, Takanobu

写真a

Affiliation

Faculty of Science and Engineering, Waseda Research Institute for Science and Engineering

Job title

Researcher(Associate Professor)
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Concurrent Post 【 display / non-display 】

  • Faculty of Science and Engineering   Graduate School of Advanced Science and Engineering

  • Faculty of Science and Engineering   School of Creative Science and Engineering

  • Faculty of Science and Engineering   Graduate School of Creative Science and Engineering

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Education 【 display / non-display 】

  • 2004.10
    -
    2007.09

    Waseda University  

  • 2004.04
    -
    2007.04

    豪州国立研究所CSIRO   先端流体計測研究室  

  • 2003.04
    -
    2004.09

    Waseda University  

  • 1997.04
    -
    2002.03

    Waseda university   Science and Engineering   Dept of Mechanical Engineering  

  • 2000.08
    -
    2001.08

    California State University  

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Degree 【 display / non-display 】

  • 早稲田大学   博士（工学）

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Research Experience 【 display / non-display 】

  • 2018.04
    -
    Now

    Tokyo Women's Medical University

  • 2018.04
    -
    Now

    Waseda University   Faculty of Science and Engineering

  • 2017.04
    -
    2018.03

    Waseda University   Faculty of Science and Engineering

  • 2013.04
    -
    2017.06

    イービーエム株式会社   血流解析事業部   部長

  • 2014.04
    -
    2017.03

    Waseda University   Faculty of Science and Engineering

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Professional Memberships 【 display / non-display 】

  • 　
    　
    　

    JAPANESE SOCIETY OF RADIOLOGICAL TECHNOLOGY

  • 　
    　
    　

    THE VISUALIZATION SOCIETY OF JAPAN

  • 　
    　
    　

    JAPANESE SOCIETY OF BIORHEOLOGY

  • 　
    　
    　

    THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

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Research Areas 【 display / non-display 】

  • Human pathology

  • Medical technology assessment

  • Cell biology

  • Fluid engineering

  • Neurosurgery

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Research Interests 【 display / non-display 】

  • Thrombosis

  • Hemolysis

  • Cell death

  • Biomechanics

  • cellular interactions

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Papers 【 display / non-display 】

  • Vascular responses to abrupt blood flow change after bypass surgery for complex intracranial aneurysms.

    Kataoka H, Makino Y, Takanishi K, Kimura Y, Takamura K, Yagi T, Iguchi S, Yamamoto A, Iida H, Ogata S, Nishimura K, Nakamura M, Umezu M, Iihara K, Takahashi JC

    Acta neurochirurgica   160 ( 10 ) 1945 - 1953  2018.10  [Refereed]

    DOI PubMed

  • Hemodynamic features of offending vessels at neurovascular contact in patients with trigeminal neuralgia and hemifacial spasm.

    Satoh T, Yagi T, Onoda K, Kameda M, Sasaki T, Ichikawa T, Date I

    Journal of neurosurgery     1 - 7  2018.07  [Refereed]

    DOI PubMed

  • A computational fluid dynamics (CFD) study of WEB-treated aneurysms: Can CFD predict WEB "compression" during follow-up?

    Jildaz Caroff, Cristian Mihalea, Valerio Da Ros, Takanobu Yagi, Marta Iacobucci, Leon Ikka, Jacques Moret, Laurent Spelle

    JOURNAL OF NEURORADIOLOGY   44 ( 4 ) 262 - 268  2017.07  [Refereed]

    　View Summary

    Background. - Recent reports have revealed a worsening of aneurysm occlusion between WEB treatment baseline and angiographic follow-up due to "compression" of `the device.
    Objective. - We utilized computational fluid dynamics (CFD) in order to determine whether the underlying mechanism of this worsening is flow related.
    Methods. - We included data from all consecutive patients treated in our institution with a WEB for unruptured aneurysms located either at the middle cerebral artery or basilar tip. The CFD study was performed using pre-operative 3D rotational angiography. From digital subtraction follow-up angiographies patients were dichotomized into two groups: one with WEB "compression" and one without. We performed statistical analyses to determine a potential correlation between WEB compression and CFD inflow ratio.
    Results. - Between July 2012 and June 2015, a total of 22 unruptured middle cerebral artery or basilar tip aneurysms were treated with a WEB device in our department. Three patients were excluded from the analysis and the mean follow-up period was 17 months. Eleven WEBs presented "compression" during follow-up. Interestingly, device "compression" was statistically correlated to the CFD inflow ratio (P=0.018), although not to aneurysm volume, aspect ratio or neck size.
    Conclusion. - The mechanisms underlying the worsening of aneurysm occlusion in WEB-treated patients due to device compression are most likely complex as well as multifactorial. However, it is apparent from our pilot study that a high arterial inflow is, at least, partially involved. Further theoretical and animal research studies are needed to increase our understanding of this phenomenon. (C) 2017 Elsevier Masson SAS. All rights reserved.

    DOI PubMed

  • Fluid mechanical interpretation of changes in cerebral vascular peripheral resistance caused by bypass surgery

    Masanori NAKAMURA, Yuta SUGAWARA, Kiyofumi TAKANISHI, Akihide YAMAMOTO, Satoshi IGUCHI, Takanobu YAGI, Hiroharu KATAOKA

    The Proceedings of Mechanical Engineering Congress, Japan   2017 ( 0 ) J0230201  2017  [Refereed]

    DOI

  • Three-dimensional pathological analysis of cerebral aneurysm initiation

    Xinning Wang, Kenta Suto, Takanobu Yagi, Koichi Kawamura, Mitsuo Umezu

    Communications in Computer and Information Science   761   95 - 103  2017  [Refereed]

    　View Summary

    Cerebral aneurysm is known to initiate at the cerebral artery bifurcation. The pathological mechanism of cerebral aneurysm awaits further understanding especially on its initiation. This study sought to elucidate the three-dimensional structure of cerebral vascular bifurcations with and without aneurysms using human cadavers. The two cases had aneurysmal initiations out of total 7 cases. The studied structure was intimal hyperplasia, tunica media and internal elastic lamina, which were recognized by elastica masson staining. The results showed that the non-existence of tunica media and internal elastic lamina was found in the lesion without aneurysm. The non-existence of intimal hyperplasia was only found in the lesion with aneurysm. These data suggest that the formation of intimal hyperplasia may be related with the initiation of aneurysm. We regarded the boundary of existence arteriosclerosis as the position for new arteriosclerosis occurs and thought the direction of new arteriosclerosis grows would influence whether the cerebral aneurysm initiates or not.

    DOI

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Books and Other Publications 【 display / non-display 】

  • 基礎からよくわかる実践的CFD（数値流体力学）入門

    八木 高伸( Part： Contributor, 7.3 CFDの論文の書き方ポイント、7.4 数値流体力学を原理から現場へ)

    メディカ出版  2017

  • 次世代診断治療支援のための血流シミュレーション

    八木 高伸( Part： Joint author, 第3章 血流シミュレーションの方法、第5章 血流シミュレーションの結果と解釈、第6章 血流シミュレーションの事例)

    日本機械学会  2016

  • 医療現場のための数値流体力学（全7回）

    八木 高伸( Part： Sole author)

    日本診療放射線技師会誌  2014

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Misc 【 display / non-display 】

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Industrial Property Rights 【 display / non-display 】

  • 血管病の病態再構築に関する方法、疾患モデル及び装置

    八木高伸, 坂口勝久, 亀岡洋一郎

    Patent

  • 漏出検出センサおよび薬液注入システム

    朴栄光, 八木高伸, 小野世一, 川辺朋之, 伊藤達也

    Patent

  • ミキシングデバイス、ミキシングチューブ、薬液注入システム及び薬液の混合方法

    八木高伸, 朴栄光, 梅津光生

    Patent

  • 気管チューブ、膨張性カフ、及び封止部材

    森岡 宣伊, 永井 美玲, 尾崎 眞, 八木 高伸, 石井 裕之, 高西 淳夫, 戸部 泰貴

    Patent

  • 血流性状診断のためのシステム、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

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Awards 【 display / non-display 】

  • 優秀ポスター賞銅賞

    2018   日本脳神経血管内治療学会総会   ヒト脳動脈瘤の退行性変化と破裂メカニズムに関する検討

    Winner： 吉田浩貴, 八木高伸, 西谷和敏, 岡田義文, 川村公一, 須藤健太, 梅津光生, 北原茂美

  • 優秀講演フェロー賞

    2017   機械学会バイオフロンティア   ヒト脳動脈瘤破裂因子の特定に向けた病理工学的検討 壁の菲薄化と炎症細胞の関連性

    Winner： 須藤健太, 八木高伸, 王心寧, 川村公一, 梅津光生, 吉田浩貴, 西谷和俊, 岡田義文, 北原茂実

  • Best Poster Award

    2016   ICBME   Proposal of mathematical auto-regulation model for cerebral blood flow rate prediction of cerebral bypass surgery

    Winner： Takanishi K, Yagi T, Umezu M

  • YIA

    2013   ICBME   Relationship between pathology and hemodynamics of human unruptured cerebral aneurysms

    Winner： Tobe Y, Yagi T, Kawamura K, Umezu M

  • 若手研究者支援事業アーリーバード（第二期生）

    2012   早稲田大学   脳血管疾患の診断・治療の新展開：血流診断の実用化に向けた安全性に関する研究

    Winner： 八木 高伸

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Research Projects 【 display / non-display 】

  • 非臨床性能評価を深化する超小型血液循環シミュレータの開発

    Project Year :

    2018.04
    -
    2021.03
     

    梅津 光生

  • SHG光計測による瞬時大変形した赤血球の膜損傷の可視化と損傷度の定量

    Project Year :

    2018.04
    -
    2021.03
     

    中村 匡徳

  • 新規治療機器を実臨床に導入時に有効な循環シミュレータの開発

    Project Year :

    2015.04
    -
    2018.03
     

    梅津 光生

  • 数値流体力学による冠動脈機能的狭窄の非侵襲診断ソフトウェアの開発

    Project Year :

    2016.04
    -
    2017.03
     

    斎藤 成達

  • 数値流体力学による脳動脈瘤血管内治療リスク判定システムの開発

    Project Year :

    2016.04
    -
    2017.03
     

    坂田 隆史, 八木 高伸

    Authorship： Principal investigator

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Presentations 【 display / non-display 】

  • 数値流体力学（CFD）による冠動脈血流シミュレーション

    八木 高伸  [Invited]

    FRIENDS 

    Presentation date： 2017

  • 数値流体力学（CFD）による心臓，脳血管障害の診断治療支援：現状と展望

    八木 高伸  [Invited]

    日本放射線技術学会近畿支部平成29年度秋季勉強会 

    Presentation date： 2017

  • 医工連携による脳動脈瘤の病態解明―次世代診断治療支援技術を目指して―

    八木 高伸  [Invited]

    第19回中国四国脳卒中研究会 

    Presentation date： 2017

  • Computational Fluid Dynamics for Assisting Neurosurgery: Basic Principles

    八木 高伸  [Invited]

    第13回国際脳卒中外科学会 

    Presentation date： 2017

  • 数値流体力学による脳動脈瘤の血流解析：15年のレビュー

    八木 高伸  [Invited]

    第33回NPO法人日本脳神経血管内治療学会学術総会 

    Presentation date： 2017

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Syllabus 【 display / non-display 】

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Teaching Experience 【 display / non-display 】

  • 医用機械工学研究

    早稲田大学  

  • 臨床医工学概論

    早稲田大学  

  • 臓器工学特論

    早稲田大学  

  • フルーイドダイナミクス

    早稲田大学  

  • メカニカルエンジニアリングラボ

    早稲田大学  

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Committee Memberships 【 display / non-display 】

  • 2018.07
    -
    Now

    脳血管CFD解析実用化委員会  事務局

  • 2018.04
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    Now

    日本放射線技術学会  医用画像標準化委員

  • 2016.04
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    Now

    日本機械学会バイオエンジニアリング  講習会講師

  • 2016.04
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    Now

    日本機械学会バイオエンジニアリング  運営委員会

  • 2015.04
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    Now

    日本バイオレオロジー学会  企画小委会血管内治療

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