Updated on 2022/05/26

写真a

 
YAGI, Takanobu
 
Affiliation
Faculty of Science and Engineering, Waseda Research Institute for Science and Engineering
Job title
Researcher(Associate Professor)

Concurrent Post

  • Faculty of Science and Engineering   Graduate School of Creative Science and Engineering

  • Faculty of Science and Engineering   Graduate School of Advanced Science and Engineering

  • Faculty of Science and Engineering   School of Creative Science and Engineering

Education

  • 2004.10
    -
    2007.09

    Waseda University  

  • 2004.04
    -
    2007.04

    豪州国立研究所CSIRO   先端流体計測研究室  

  • 2003.04
    -
    2004.09

    Waseda University  

  • 1997.04
    -
    2002.03

    Waseda university   Science and Engineering   Dept of Mechanical Engineering  

  • 2000.08
    -
    2001.08

    California State University  

Degree

  • 早稲田大学   博士（工学）

Research Experience

  • 2018.04
    -
    Now

    Tokyo Women's Medical University

  • 2018.04
    -
    Now

    Waseda University   Faculty of Science and Engineering

  • 2017.04
    -
    2018.03

    Waseda University   Faculty of Science and Engineering

  • 2013.04
    -
    2017.06

    イービーエム株式会社   血流解析事業部   部長

  • 2014.04
    -
    2017.03

    Waseda University   Faculty of Science and Engineering

  • 2013.04
    -
    2014.03

    Waseda University   Faculty of Science and Engineering

  • 2011.04
    -
    2013.03

    Waseda University   Faculty of Science and Engineering

  • 2009.04
    -
    2011.03

    早稲田大学先進理工学研究科GCOE   研究助手

  • 2007.10
    -
    2010.09

    CSIRO, Australia   Advanced Laser Diagnostic Fluid Dynamics Laboratory   Visiting Research Associate

  • 2007.10
    -
    2009.03

    Waseda University Faculty of Science and Engineering   Waseda Research Institute for Science and Engineering   Research Associate

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Professional Memberships

  • 　
    　
    　

    JAPANESE SOCIETY OF RADIOLOGICAL TECHNOLOGY

  • 　
    　
    　

    THE VISUALIZATION SOCIETY OF JAPAN

  • 　
    　
    　

    JAPANESE SOCIETY OF BIORHEOLOGY

  • 　
    　
    　

    THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

 

Research Areas

  • Biomedical engineering

  • Medical technology assessment

  • Biomaterials

  • Cell biology

  • Fluid engineering

  • Human pathology

  • Neurosurgery

  • Experimental pathology

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Research Interests

  • Thrombosis

  • Hemolysis

  • Cell death

  • Biomechanics

  • cellular interactions

  • Diagnositc and treatment assisting technology

  • Medical device R&D

  • Carotid plaque

  • Optical imaging

  • Tissue culture technique R&D

  • Pathology

  • Atherosclerosis

  • Cerebral Aneurysm

  • Microfluidics

  • Blood flow dynamics

  • Vascular Remodeling

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Papers

  • Vascular responses to abrupt blood flow change after bypass surgery for complex intracranial aneurysms.

    Kataoka H, Makino Y, Takanishi K, Kimura Y, Takamura K, Yagi T, Iguchi S, Yamamoto A, Iida H, Ogata S, Nishimura K, Nakamura M, Umezu M, Iihara K, Takahashi JC

    Acta neurochirurgica   160 ( 10 ) 1945 - 1953  2018.10  [Refereed]

    DOI PubMed

  • Hemodynamic features of offending vessels at neurovascular contact in patients with trigeminal neuralgia and hemifacial spasm.

    Satoh T, Yagi T, Onoda K, Kameda M, Sasaki T, Ichikawa T, Date I

    Journal of neurosurgery     1 - 7  2018.07  [Refereed]  [International journal]

    　View Summary

    OBJECTIVEOffending vessels at the site of neurovascular contact (NVC) in patients with trigeminal neuralgia (TN) and hemifacial spasm (HFS) may have specific hemodynamic features. The purpose of this study was to investigate the wall shear stress (WSS) of offending vessels at NVCs by conducting a computational fluid dynamics (CFD) analysis.METHODSThe authors retrospectively analyzed the cases of 20 patients (10 with TN and 10 with HFS) evaluated by 3D CT angiography and used the imaging findings for analysis of the hemodynamic parameters. The 3D CFD images were directly compared with the NVCs determined by simulated multifusion images of CT angiogram and MR cisternogram, and operative photos. The magnitudes of the WSS (WSSm) at the proximal (WSSm-p), just-beginning (WSSm-j), contact site (WSSm-s), and distal (WSSm-d) areas of each NVC were analyzed. The ratios of the WSSm-j, WSSm-s, and WSSm-d areas to the WSSm-p area were calculated individually. The direction of the WSS (WSSv) and its temporal variation (WSSvV) were depicted and morphologically compared with the NVC confirmed by simulated images and operative findings.RESULTSThe ratios of WSSm at the just-beginning and the contact site to the proximal area of the NVCs (WSSm-j/WSSm-p and WSSm-s/WSSm-p) were both significantly higher than that at the distal area (WSSm-d/WSSm-p) (p < 0.05). The WSSv and WSSvV at the NVCs showed small variation in a single cardiac cycle, especially along the areas that were in contact with the affected nerve.CONCLUSIONSAreas of relatively high WSSm and temporal variation of WSSm (WSSmV) were observed at the NVCs. Less mobility of the WSSv and WSSvV was detected along the side of the vessels in contact with the nerves. These findings may be consistent with the actual area of the NVC. Hemodynamic features of the site of NVC can be added to the preoperative simulation for MVD surgery, which may be useful for the diagnosis and treatment planning of TN and HFS.

    DOI PubMed

  • A computational fluid dynamics (CFD) study of WEB-treated aneurysms: Can CFD predict WEB "compression" during follow-up?

    Jildaz Caroff, Cristian Mihalea, Valerio Da Ros, Takanobu Yagi, Marta Iacobucci, Leon Ikka, Jacques Moret, Laurent Spelle

    JOURNAL OF NEURORADIOLOGY   44 ( 4 ) 262 - 268  2017.07  [Refereed]

    　View Summary

    Background. - Recent reports have revealed a worsening of aneurysm occlusion between WEB treatment baseline and angiographic follow-up due to "compression" of `the device.
    Objective. - We utilized computational fluid dynamics (CFD) in order to determine whether the underlying mechanism of this worsening is flow related.
    Methods. - We included data from all consecutive patients treated in our institution with a WEB for unruptured aneurysms located either at the middle cerebral artery or basilar tip. The CFD study was performed using pre-operative 3D rotational angiography. From digital subtraction follow-up angiographies patients were dichotomized into two groups: one with WEB "compression" and one without. We performed statistical analyses to determine a potential correlation between WEB compression and CFD inflow ratio.
    Results. - Between July 2012 and June 2015, a total of 22 unruptured middle cerebral artery or basilar tip aneurysms were treated with a WEB device in our department. Three patients were excluded from the analysis and the mean follow-up period was 17 months. Eleven WEBs presented "compression" during follow-up. Interestingly, device "compression" was statistically correlated to the CFD inflow ratio (P=0.018), although not to aneurysm volume, aspect ratio or neck size.
    Conclusion. - The mechanisms underlying the worsening of aneurysm occlusion in WEB-treated patients due to device compression are most likely complex as well as multifactorial. However, it is apparent from our pilot study that a high arterial inflow is, at least, partially involved. Further theoretical and animal research studies are needed to increase our understanding of this phenomenon. (C) 2017 Elsevier Masson SAS. All rights reserved.

    DOI PubMed

  • Fluid mechanical interpretation of changes in cerebral vascular peripheral resistance caused by bypass surgery

    Masanori NAKAMURA, Yuta SUGAWARA, Kiyofumi TAKANISHI, Akihide YAMAMOTO, Satoshi IGUCHI, Takanobu YAGI, Hiroharu KATAOKA

    The Proceedings of Mechanical Engineering Congress, Japan   2017 ( 0 ) J0230201  2017  [Refereed]

    DOI

  • Three-dimensional pathological analysis of cerebral aneurysm initiation

    Xinning Wang, Kenta Suto, Takanobu Yagi, Koichi Kawamura, Mitsuo Umezu

    Communications in Computer and Information Science   761   95 - 103  2017  [Refereed]

    　View Summary

    Cerebral aneurysm is known to initiate at the cerebral artery bifurcation. The pathological mechanism of cerebral aneurysm awaits further understanding especially on its initiation. This study sought to elucidate the three-dimensional structure of cerebral vascular bifurcations with and without aneurysms using human cadavers. The two cases had aneurysmal initiations out of total 7 cases. The studied structure was intimal hyperplasia, tunica media and internal elastic lamina, which were recognized by elastica masson staining. The results showed that the non-existence of tunica media and internal elastic lamina was found in the lesion without aneurysm. The non-existence of intimal hyperplasia was only found in the lesion with aneurysm. These data suggest that the formation of intimal hyperplasia may be related with the initiation of aneurysm. We regarded the boundary of existence arteriosclerosis as the position for new arteriosclerosis occurs and thought the direction of new arteriosclerosis grows would influence whether the cerebral aneurysm initiates or not.

    DOI

  • 1E41 The relationship between demand blood flow and supply blood flow before and after revascularization

    WATANABE Mikihiko, YAGI Takanobu, TAKANISHI Kiyofumi, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, IIDA Hidehiro, NAKAMURA Masanori, UMEZU Mitsuo

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   2016 ( 0 ) _1E41 - 1_-_1E41-4_  2016  [Refereed]

    　View Summary

    Cerebral revascularization is a general surgery for vascular lesions. Operative procedures are decided based on surgeon's experience, however unpredictable complications are still a problem. The aim of our study is to predict complications before operation by identifying the mechanism of cerebral hemodynamics adaptations. It is considered that blood flow is regulated for meeting demand of tissue cells. There is a little study about the relationship between blood flow in cerebral arteries and cerebral demand. In this study, the total of flow rate in both sides internal carotid arteries and basilar artery is 'supply blood flow', and gray matter volume (V_G) and white matter volume (V_W) are multiplied by each literature cerebral blood flow (k_G, k_W) to calculate 'demand blood flow' (V_G・K_G+V_W・K_W). For 14 healthy volunteers and 2 patients (aneurysm and ischemic), the ratio of difference between demand and supply blood flow on the basis of supply values are studied. As the result, difference between supply blood flow and demand blood flow is -11.3% in healthy subjects. In a case of aneurysm, difference rate is low before and after surgery. In a case of ischemic, there is a high difference rate (59.1%). However, difference becomes lower (12.1%) by supply blood flow increase after operation. It is suggested that difference rate is available for diagnosis of ischemic.

    DOI CiNii

  • 1E41 The relationship between demand blood flow and supply blood flow before and after revascularization

    WATANABE Mikihiko, YAGI Takanobu, TAKANISHI Kiyofumi, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, IIDA Hidehiro, NAKAMURA Masanori, UMEZU Mitsuo

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   2016 ( 0 ) _1E41 - 1_-_1E41-4_  2016  [Refereed]

    　View Summary

    Cerebral revascularization is a general surgery for vascular lesions. Operative procedures are decided based on surgeon's experience, however unpredictable complications are still a problem. The aim of our study is to predict complications before operation by identifying the mechanism of cerebral hemodynamics adaptations. It is considered that blood flow is regulated for meeting demand of tissue cells. There is a little study about the relationship between blood flow in cerebral arteries and cerebral demand. In this study, the total of flow rate in both sides internal carotid arteries and basilar artery is 'supply blood flow', and gray matter volume (V_G) and white matter volume (V_W) are multiplied by each literature cerebral blood flow (k_G, k_W) to calculate 'demand blood flow' (V_G・K_G+V_W・K_W). For 14 healthy volunteers and 2 patients (aneurysm and ischemic), the ratio of difference between demand and supply blood flow on the basis of supply values are studied. As the result, difference between supply blood flow and demand blood flow is -11.3% in healthy subjects. In a case of aneurysm, difference rate is low before and after surgery. In a case of ischemic, there is a high difference rate (59.1%). However, difference becomes lower (12.1%) by supply blood flow increase after operation. It is suggested that difference rate is available for diagnosis of ischemic.

    DOI CiNii

  • Controlling sheer stress in a suspension culture using coquette, flow for efficient proliferation of HEK 293 cells

    Zin N, Sakaguchi K, Haraguchi Y, Yagi T, Shimizu T, Umezu M

    Fluid Mechanics Open Access   3 ( 1 )  2016

  • Pathological engineering analysis of human unruptured cerebral aneurysms for investigation of relationship between hemodynamic stress and smooth muscle cells

    Tobe Y, Yagi T, Kawamura K, Umezu M

    Proceedings of the ICBME 2016     28  2016  [Refereed]

  • Proposal of mathematical auto-regulation model for cerebral blood flow rate prediction of cerebral bypass surgery

    Takanishi K, Yagi T, Umezu M

    Proceedings of the ICBME 2016    2016  [Refereed]

  • Study of the consistency of wall shear stress in healthy major human cerebral arteries

    Takanishi K, Yagi T, Umezu M

    Proceedings of the 2016 Summer Biomechanics Bioengineering and Biotransport Conference,scientific sessions     218  2016  [Refereed]

  • Investigation of flow instability with vascular geometry at the bifurcation of middle cerebral arteries from healthy volunteers

    Murayoshi T, Yagi T, Tobe Y, Umezu M

    Proceedings of the 2016 Summer Biomechanics Bioengineering and Biotransport Conference     215  2016  [Refereed]

  • Pathological engineering study of human cerebral aneurysms three dimensional accumulation of foam cells versus hemodynamics

    Suto K, Yagi T, Tobe Y, Kawamura K, Umezu M

    Proceedings of the 2016 summer biomechanics bioengineering and biotransport conference     197  2016  [Refereed]

  • 2A33 Study on an adaptation of hemodynamics before and after cerebrovascular bypass surgery

    TAKAMURA Kenji, UMEZU Mitsuo, YAGI Takanobu, WATANABE Mikihiko, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, Iida Hidehiro, NUMATA Naoki, NAKAMURA Masanori

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   2015 ( 0 ) 325 - 326  2015  [Refereed]

    DOI CiNii

  • 2A33 Study on an adaptation of hemodynamics before and after cerebrovascular bypass surgery

    TAKAMURA Kenji, UMEZU Mitsuo, YAGI Takanobu, WATANABE Mikihiko, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, Iida Hidehiro, NUMATA Naoki, NAKAMURA Masanori

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   2015 ( 0 ) 325 - 326  2015  [Refereed]

    DOI CiNii

  • Induced Pluripotent Stem Cell Differentiation under Constant Shear Stress

    N. K. Mohd Zin, K. Sakaguchi, Y. Haraguchi, T. Yagi, K. Masuura, T. Shimizu, M. Umezu

    7TH WACBE WORLD CONGRESS ON BIOENGINEERING 2015   52   7 - 10  2015  [Refereed]

    　View Summary

    Mechanotransduction in in-vitro studies has yet to be done extensively using human induced pluripotent (hiPS) cells. These external mechanical factors are important controlling factor for cell differentiation at a cellular level particularly in cardiomyocytes cells. Cells in a living body are being exposed to many kind of stresses; shear stress in particular modulates cellular function in a living body. Similarly, we are trying to understand the link between the shear stress in the bioreactor and the differentiation effects it has on iPS cells. In this study, we investigate the difference of strictly uniform laminar shear stress with a non-uniform laminar flow and its effects on the cell survival rate and differentiation. Additionally, the elimination of biochemical factors were done to satisfy the need of demand for clinically usable cells for the near future use. By eliminating cytokine induced differentiation. In addition, information pertaining to relationship between fluid shear stress, cellular deformations, cell differentiation and cell survival rate could provide a more optimised condition for cultivation specific type of cells within a shorter time period.

    DOI

  • Optimal kissing balloon inflation after single-stent deployment in a coronary bifurcation model

    Yoshinobu Murasato, Kiyotaka Iwasaki, Tadashi Yamamoto, Takanobu Yagi, Yutaka Hikichi, Yasunori Suematsu, Tomohiko Yamamoto

    EUROINTERVENTION   10 ( 8 ) 934 - 941  2014.12  [Refereed]

    　View Summary

    Aims: To define the optimal kissing balloon inflation (KBI) after single-stent deployment in a coronary bifurcation model.
    Methods and results: We deployed stents in main vessels (MV) followed by KBI in various conditions and compared the stent configurations. A) KBI at the operator's discretion vs. under the guidelines of minimal balloon overlapping (MBO). Various stent configurations were observed after the former option, whereas similar maximal dilation points were observed under the MBO guidelines. B) Long balloon overlapping (LBO) vs. MBO with proximal MV dilated by a large balloon. The proximal MV was dilated to an ideal round shape with MBO versus an oval shape with LBO. C) Two-link vs. 3-link stents. Although the 2-link stent was advantageous to open the side branch, it incurred a risk of overdilatation of the proximal struts, whereas the 3-link stent preserved its structure. Computed simulations of coronary flow were analysed in the following left main coronary models: circle with a diameter of 4 and 5 5 mm, ellipse with longitudinal direction and tilt position. They revealed that the overdilated side was exposed to low shear stress regardless of its shape.
    Conclusions: Optimal KBI can be achieved with MBO and proximal dilatation by an optimally sized balloon.

    DOI PubMed

  • 1G13 Study of hemodynamics in cerebrovascular bypass surgery

    TAKAMURA Kenji, UMEZU Mitsuo, YAGI Takanobu, YAMANASHI Momoko, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, Iida Hidehiro, SATO Kota, NAKAMURA Masanori

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   2014 ( 0 ) 211 - 212  2014  [Refereed]

    DOI CiNii

  • 1G13 Study of hemodynamics in cerebrovascular bypass surgery

    TAKAMURA Kenji, UMEZU Mitsuo, YAGI Takanobu, YAMANASHI Momoko, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, Iida Hidehiro, SATO Kota, NAKAMURA Masanori

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   2014 ( 0 ) 211 - 212  2014  [Refereed]

    DOI CiNii

  • Relationship between pathology and hemodynamics of human unruptured cerebral aneurysms

    Yasutaka Tobe, Takanobu Yagi, Yuki Iwabuchi, Momoko Yamanashi, Kenji Takamura, Takuma Sugiura, Mitsuo Umezu, Yoshifumi Hayashi, Hirotaka Yoshida, Atsushi Nakajima, Kazutoshi Nishitani, Yoshifumi Okada, Michihito Sugawara, Shin Hiraguchi, Toshiro Kubo, Shigemi Kitahara

    IFMBE Proceedings   43   44 - 47  2014  [Refereed]

    　View Summary

    This research compared the intraoperative appearance, computational fluid dynamic (CFD) analysis, and scanning electron microscope (SEM) observation of endothelial cells (EC) of seven human cerebral aneurysms in an effort to find the relationship between hemodynamic patterns and wallthinning of aneurysms. Aneurysm walls were categorized into blister-like appearance as thinning, similar appearance to the parental artery or white thickened part as thickening, and areas similar to arteriosclerosis as calcifying region. Seven aneurysms were dissected after clipping operation with markings to confirm the orientation of specimens. Specimens were rinsed in PBS, immersed into 2% glutaraldehyde, 1% osmium solution, graded series of ethanol and tertiary-butyl alcohol, and freeze-dried to observe under SEM. For CFD analysis, 3 dimensional vascular models were constructed and meshed using tetra and prism mesh. The inlet boundary condition used an average flow rate of 350 ml/min. The outlet boundary conditions were set to flow rates based on literature data and for regions with unknown flow rates were set to static pressure. Vascular models were analyzed using CFX 13.0 (ANSYS). Aneurysms contained four thinning, six thickening, and four calcifying regions. SEM analysis showed variations of endothelial cell patterns over aneurysms. Missing EC was only found at thinning regions and all thickening and calcifying regions confirmed damaged or normal EC. CFD analysis showed impinging flow at the thinning region. Impingement was defined by the direction of wall shear stress (WSS) vector and rise of pressure at wall. The impinging flow was only found at the thinning region. The WSS magnitude did not confirm any relationship between wall characteristics or EC patterns. These results suggested that the impinging flow may cause wall thinning of aneurysm.

    DOI

  • COMBINED ANALYSIS OF PATHOLOGY AND HEMODYNAMICS OF HUMAN UNRUPTURED CEREBRAL ANEURYSM WITH THIN-WALLED REGION

    Yasutaka Tobe, Takanobu Yagi, Yuki Iwabuchi, Momoko Yamanashi, Kenji Takamura, Kiyotaka Iwasaki, Mitsuo Umezu, Yoshifumi Hayashi, Hirotaka Yoshida, Atsushi Nakajima, Kazutoshi Nishitani, Yoshifumi Okada, Michihito Sugawara, Shin Hiraguchi, Toshiro Kubo, Shigemi Kitahara

    PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A    2014  [Refereed]

    DOI

  • Visual analytics of malignant blood flow for medical professionals

    Takanobu Yagi, Takeharu Hoshi, Young Park

    2014 IEEE Pacific Visualization Symposium (PacificVis)     342 - 343  2014  [Refereed]

    　View Summary

    Arterial diseases of sclerosis and aneurysm are known to be related with a local blood flow. There are indeed decades of related studies, recently being with an aid of a computational approach on a patient-specific basis, but those have yet to be translated into clinical medicine. "Simply why?", and "how to achieve it?" Computational blood flow originates from theoretical and computational fluid dynamics. Understanding the underlying knowledge may be beyond the scope of medical professionals. Engineers have to be fully aware of a barrier on an interface with clinical medicine, and manage to translate the evolving technology with a special focus on balancing the efficacy and safety. Visual analytics is to facilitate to overcome an academic gap between engineering and clinical medicine. This paper deals with the recent development of visual analytics of malignant blood flows in cerebral aneurysms for medical professionals.

    DOI

  • Novel connecting tube for saline chaser in contrast-enhanced CT: The effect of spiral flow of saline on contrast enhancement

    Masafumi Kidoh, Takeshi Nakaura, Kazuo Awai, Koji Yuba, Takayuki Kobayashi, Young-Kwang Park, Takanobu Yagi, Kazunori Harada, Yasuyuki Yamashita

    European Radiology   23 ( 11 ) 3213 - 3218  2013.11  [Refereed]

    　View Summary

    Objective: To evaluate the effect of a newly developed connecting tube, which generates a spiral flow of saline, on aortic and hepatic contrast enhancement during hepatic-arterial phase (HAP) and portal venous phase (PVP) computed tomography (CT). Methods: Eighty patients were randomly assigned to one of two protocols: with a new or a conventional tube. The contrast material (600 mgI/kg) was delivered over 30 s
    this was followed by the administration of 25 ml saline solution delivered at the same injection rate as the contrast material. Unenhanced and contrast-enhanced CT images of the upper abdomen were obtained. We calculated the changes in the CT number (â̂†HU) for the aorta during HAP and PVP, and for the liver during PVP. We compared â̂†HU between protocols. Results: The mean â̂†HU for the abdominal aorta during HAP was significantly higher with the new tube protocol than with the conventional tube protocol (322 ± 53 vs. 290 ± 53, P &lt
    0.01). There were no significant differences in the mean â̂†HU for the abdominal aorta and liver during PVP between the two protocols (P &gt
    0.05). Conclusion: The new connecting tube increased the effect of a saline chaser and significantly improved aortic enhancement during HAP. © 2013 European Society of Radiology.

    DOI PubMed

  • Numerical analysis of blood flow distribution in 4-and 3-branch vascular grafts

    Chikako Konoura, Takanobu Yagi, Masanori Nakamura, Kiyotaka Iwasaki, Yi Qian, Shigeo Okuda, Akihiro Yoshitake, Hideyuki Shimizu, Ryohei Yozu, Mitsuo Umezu

    JOURNAL OF ARTIFICIAL ORGANS   16 ( 2 ) 157 - 163  2013.06  [Refereed]

    　View Summary

    Trifurcated arch grafts (3-branch grafts) are now being used to repair the thoracic aorta in addition to conventional arch grafts (4-branch grafts). The anatomical shape of the 3-branch graft is different from the original vessel, so it is necessary for clinical application to evaluate blood flow distribution in the graft to assess whether there is adequate blood flow to the target organs. To achieve this, we developed a computational fluid dynamics (CFD) method to evaluate blood flow distribution in the grafts. Aortic blood flow was measured by phase-contrast magnetic resonance imaging (PC-MRI), and flow distribution into the branched vessels was obtained. The MRI image was used to create a patient-specific image model that represents the geometry of the aortic arch. The CFD analysis method was employed to determine a boundary condition of the blood flow analysis in the aorta using a patient-specific image model. We also created simplified models of 4-branch and 3-branch grafts and used our CFD analysis method to compare blood flow distribution among simplified models. It was found that blood flow distribution in the descending aorta was 71.3 % for the 4-branch graft and 67.7 % for the 3-branch graft, indicating that a sum of branching flow in the 3-branch graft was almost the same as the one in the 4-branch graft. Therefore, there is no major concern about implanting a new 3-branch graft. Our CFD analysis method may be applied to estimate blood flow distribution of a newly developed vascular graft prior to its clinical use and provide useful information for safe use of the graft.

    DOI PubMed

  • Experimental insights into flow impingement in cerebral aneurysm by stereoscopic particle image velocimetry: transition from a laminar regime

    Takanobu Yagi, Ayaka Sato, Manabu Shinke, Sara Takahashi, Yasutaka Tobe, Hiroyuki Takao, Yuichi Murayama, Mitsuo Umezu

    JOURNAL OF THE ROYAL SOCIETY INTERFACE   10 ( 82 ) 20121031  2013.05  [Refereed]

    　View Summary

    This study experimentally investigated the instability of flow impingement in a cerebral aneurysm, which was speculated to promote the degradation of aneurysmal wall. A patient-specific, full-scale and elastic-wall replica of cerebral artery was fabricated from transparent silicone rubber. The geometry of the aneurysm corresponded to that found at 9 days before rupture. The flow in a replica was analysed by quantitative flow visualization (stereoscopic particle image velocimetry) in a three-dimensional, high-resolution and time-resolved manner. The mid-systolic and late-diastolic flows with a Reynolds number of 450 and 230 were compared. The temporal and spatial variations of near-wall velocity at flow impingement delineated its inherent instability at a low Reynolds number. Wall shear stress (WSS) at that site exhibited a combination of temporal fluctuation and spatial divergence. The frequency range of fluctuation was found to exceed significantly that of the heart rate. The high-frequency-fluctuating WSS appeared only during mid-systole and disappeared during late diastole. These results suggested that the flow impingement induced a transition from a laminar regime. This study demonstrated that the hydrodynamic instability of shear layer could not be neglected even at a low Reynolds number. No assumption was found to justify treating the aneurysmal haemodynamics as a fully viscous laminar flow.

    DOI PubMed

  • Prediction of Wall-thinning Area in Unruptured Intracerebral Aneurysms by Computational Fluid Dynamics

    Yoshifumi Hayashi, Takanobu Yagi, Yasutaka Tobe, Yuki Iwabuchi, Momoko Yamanashi, Kenji Takamura, Kiyotaka Iwasaki, Mitsuo Umezu, Takashi Ishida, Atsushi Nakajima, Hirotaka Yoshida, Kazutoshi Nishitani, Yoshihisa Ota, Michihito Sugawara, Yoshifumi Okada, Toshiro Kubo, Shigemi Kitahara

    STROKE   44 ( 2 )  2013.02  [Refereed]

  • Relationship between pathology and hemodynamics of human unruptured cerebral aneurysms

    Tobe Y, Yagi T, Kawamura K, Umezu M

    Proceedings of the ICBME 2013     55 - 56  2013  [Refereed]

  • Investigation of collision dynamics and destruction of human erythrocytes with varying elongation using high-speeg microfluidics

    Umetani K, Yagi T, Umezu M

    Proceedings of the FULUCOME 2013    2013  [Refereed]

  • Comparison of endothelial cells and hemodynamic flow patterns of three human unruptured cerebral aneurysms

    Tobe Y, Yagi T, Kawamura K, Umezu M

    Proceedings of the FULUCOME 2013    2013  [Refereed]

  • INVESTIGATION ON A RELATIONSHIP BETWEEN HEMODYNAMICS AND WALL-THINNING IN AN UNRUPTURED HUMAN CEREBRAL ANEURYSM

    Yasutaka Tobe, Takanobu Yagi, Sara Takahashi, Yuki Iwabuchi, Momoko Yamanashi, Kiyotaka Iwasaki, Mitsuo Umezu, Yoshifumi Hayashi, Hirotaka Yoshida, Kazutoshi Nishitani, Yoshifumi Okada, Michihito Sugawara, Shin Hiraguchi, Toshiro Kubo, Shigemi Kitahara

    PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B     853 - 854  2012  [Refereed]

    DOI

  • Effect of bileaflet valve orientation on the 3d flow dynamics in the sinus of valsalva

    Takanobu Yagi, William Yang, Mitsuo Umezu

    Journal of Biomechanical Science and Engineering   6 ( 2 ) 64 - 78  2011  [Refereed]

    　View Summary

    Three-dimensional (3D) evolutional behavior of flow dynamics in the aortic sinus of Valsalva was studied in vitro for finding the effects of bileaflet valve orientations in an effort to investigate possible linkages between the sinus flow and coronary circulation. A realistic model of the aortic sinus was machined inside an acrylic block. A St. Jude Medical bileaflet aortic valve was utilized. Two orientations were compared
    (1) a pair of hinges aligned in the direction of the non-coronary sinus of the model (N0) and (2) of the left and right sinuses (N90). A 3D scanning three-component velocity measurement, named Fluorescent Scanning Stereoscopic Particle Image Velocimetry (FS-SPIV), was developed. Measured data were validated with an aid of two-dimensional particle image velocimetry. Good agreement confirmed the capability of quantifying the 3D mean and turbulent behavior of sinus vortices. The valve orientation was found to be unable to affect the sinus vortices during peak-systole, but had a substantial impact on regurgitation during end-systole. The superior case (N0) gave a symmetric regurgitation. The regurgitant jet was directed to the non-coronary sinus. The left and right sinuses were dominated by a well-organized recirculation from a persistent forward flow. The inferior case (N90) produced an asymmetric regurgitation with a biased jet into the left or right sinuses, leading to produce unexpected turbulence near the entrance of coronary artery. Those results suggest possible linkages between the sinus flow and coronary circulation, thereby advocating the existence of an optimal orientation of bileaflet valves. © 2011 by JSME.

    DOI

  • 単一細胞高速イメージングによるヒト赤血球衝突破壊動態の検討

    木田大輔, 八木高伸, 梅津光生

    可視化情報学会誌   31 ( 1 ) 391 - 394  2011

  • ヒト脳動脈瘤の組織変性プロセスに関与する異常血流の特定に向けて：ブレブ発生・成長と衝突流れの相関

    八木高伸, 林祥史, 梅津光生

    日本機械学会2011年度年次大会講演論文集    2011

  • Experimental insight into modeling of cerebral aneurysm hemodynamics: comparison between Stereo PIV and CFD

    Takahashi S, Yagi T, Umezu M

    Proceedings of 11th Asian Symposium on Visualization    2011  [Refereed]

  • Experimental insight into spatial and temporal dynamics of wall shear rate using elastic replicas of human cerebral aneurysms with fluorescent Stereo PIV

    Yagi T, Shinke M, Umezu M

    Proceedings of 11th Asian Symposium on Visualization    2011  [Refereed]

  • "Wind tunnel" in vascular hemodynamics: why and how?

    Yagi T, Takahashi S, Tobe Y, Umezu M, Takao H, Murayama Y

    Proceedings of the FULUCOME 2011    2011  [Refereed]

  • Wall shear stress measurement on an elastic boundary in hemodynamic modeling of cerebral aneurysm using fluorescent scanning Stereo PIV

    Yagi T, Takahashi S, Umezu M

    Proceedings of 9th International Symposium on Particle Image Velocimetry    2011  [Refereed]

  • Two Stenting at Coronary Artery Bifurcation Yields Slow-Flow Region at Carina: In vitro Pulsatile Flow Investigation Using Elastic 3-Dimensional Stenotic Bifurcated Artery Replica

    Kiyotaka Iwasaki, Takanobu Yagi, Tadashi Yamamoto, Yuichi Yagishita, Manabu Shinke, Yusuke Noguchi, Sara Takahashi, Mitsuo Umezu

    CIRCULATION   122 ( 21 )  2010.11  [Refereed]

  • Single-cell real-time imaging of flow-induced hemolysis using high-speed microfluidic technology

    T. Yagi, S. Wakasa, N. Tokunaga, Y. Akimoto, M. Umezu

    WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, VOL 25, PT 4: IMAGE PROCESSING, BIOSIGNAL PROCESSING, MODELLING AND SIMULATION, BIOMECHANICS   25 ( 4 ) 2337 - 2340  2010  [Refereed]

    　View Summary

    Understanding the mechanism of flow-induced blood cell damage, such as hemolysis and platelet activation, plays an important role for arterial diseases and artificial organs. This study for the first time demonstrates the visualization of flow-induced hemolysis in a single-cell real-time manner using high-speed microfluidic technology. Impinging microjets with a velocity of 1.5 m/s order at a nozzle exit were made in the Y- and T-shaped microchannel. The curved (r=10 mu m) and flat collision surface were compared. Porcine fresh erythrocytes were suspended in PBS at Ht=0.5%. Results showed that membrane failure was only observed in the Y-junction. These erythrocytes were initially elongated at the far region, and then longitudinally compressed in the near wall region due to the sharp adverse pressure gradient, whereas those in the T-junction released the membrane tension as the pressure difference per erythrocyte diminished. In the simulation of energy balance, it was found that the dominant force for the longitudinal compression was the pressure difference per erythrocyte. Such erythrocytes showed the sudden drop of elastic modulus, suggesting that the elongated spectrin network of erythrocyte was fragile for the compressive force and immediately broken by the impact force.

    DOI

  • High-speed microfluidic study of colliding human erythrocytes at a single-cell real-time scale

    Yagi T, Akimoto Y, Umezu M

    Proceedings of 6th World Congress on Biomechanics    2010  [Refereed]

  • 3D near-wall flow mapping by fluorescent Stereo-PIV in an elastic replica of human cerebral aneurysm

    Yagi T, Sato A, Umezu M

    Proceedings of International Symposium on Flow Visualization 2010    2010  [Refereed]

  • Biomedical Engineering Analysis of the Rupture Risk of Cerebral Aneurysms: Flow Comparison of Three Small Pre-ruptured Versus Six Large Unruptured Cases

    A. Kamoda, T. Yagi, A. Sato, Y. Qian, K. Iwasaki, M. Umezu, T. Akutsu, H. Takao, Y. Murayama

    13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3   23 ( 1-3 ) 1600 - +  2009  [Refereed]

    　View Summary

    A relationship between blood flows in cerebral aneurysms and their rupture remains obscure. In clinical practice, the size of aneurysms is one of the important factors for determining a strategy of treatment, but in our database three small aneurysms became ruptured during follow-up. Here, we aim to study their pre-ruptured hemodynamics, and differentiate them with those of six large unruptured aneurysms. All the aneurysms occurred in internal carotid artery, and their mean sizes were 6 and 10.8 mm for pre-ruptured and unruptured cases, respectively. We reproduced their replica as a patient-specific elastic model using clinical images obtained by digital subtraction angiography and a series of rapid proto-typing techniques. Flows were reproduced in vitro using a cerebral flow simulator, and visualized by Time-resolved Particle Image Velocimetry. All pre-ruptured cases showed the collision of an incoming flow at a distal neck, and formed a prominent jet stream directing towards the aneurismal head. In contrast, none of unruptured aneurysms had such a marked impingement, and their flows were most likely characterized by swirling patterns. All unruptured cases occurred in a twisted vessel, or carotid siphon, whereas pre-ruptured ones were located downstream whose geometries consisted of a simple curvature. These findings suggest that internal carotid artery has a regional dependency of the risk of aneurismal rupture. Furthermore, the presence of jet streams for small-sized aneurysms may be a substantial indicator of the rupture and immediate treatments.

    DOI

  • Microscale Visualization of Erythrocyte Deformation by Colliding with a Rigid Surface Using a High-Speed Impinging Jet

    S. Wakasa, T. Yagi, Y. Akimoto, N. Tokunaga, K. Iwasaki, M. Umezu

    13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3   23 ( 1-3 ) 1422 - +  2009  [Refereed]

    　View Summary

    Erythrocyte deformation by colliding with a rigid surface using a high-speed impinging jet was studied with microfluidic techniques. We aim to investigate the relevance of colliding erythrocytes with hemolysis. A micro-channel chip was made of polydimenthyl-siloxane (PDMS), which comprised a T- and V-shaped junction with a micro-nozzle and diffuser in order to attain a high-speed microflow with a jet velocity of m/s scale. A high-speed camera with a microscope imaged colliding erythrocytes by shadow imaging. Porcine erythrocyte with a hematocrit of 0.5% in phosphate buffer saline was utilized. At the Y-junction, erythrocytes showed buckling due to an impulsive, longitudinal, compressive deformation. Such anomalous phenomena were not detected at the T-junction, where erythrocytes underwent sequential compressions as approaching the colliding surface. Erythrocyte after buckling showed a hazy membrane while being released from the colliding surface, suggesting the ejection of hemoglobin out of the pore on a membrane. Flow-induced hemolysis has been considered as a model of viscous shear stress and exposure time. From our data, however, it was suggested that hemolysis due to a high-speed impinging flow characterized by mechanical heart valve flows may arise as an impulsive failure of erythrocyte membrane upon collision.

    DOI

  • New challenge for studying flow-induced blood damage: macroscale modeling and microscale verification

    T. Yagi, S. Wakasa, N. Tokunaga, Y. Akimoto, T. Akutsu, K. Iwasaki, M. Umezu

    13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3   23 ( 1-3 ) 1430 - +  2009  [Refereed]

    　View Summary

    Prosthetic heart valves often induce blood cell trauma, but its mechanism is not clearly understood due to the complexity of dynamical flows. We herein propose a new challenge, termed macroscale modeling and microscale verification. This report is the former, and here we aim to clarify the physical interpretation of Reynolds stress for flowing cells. One polymer and two mechanical valves are compared, and the Reynolds stress is visualized using a novel analytical technique including time-resolved particle image velocimetry and continuous wavelet transform. The method enables to analyze the dynamics of Reynolds stress in a spatial and temporal domain. As a result, it is found that the Reynolds stress should be considered as an indicator of impinging flows for circulating cells. Such flows may impulsively apply a colliding force on a membrane of flowing cells. As microscale verification based on this new hypothesis, we are currently investigating such collision phenomena of flowing cells using high-speed microfluidic techniques.

    DOI

  • Collision dynamics of red blood cells using high-speed impinging microjets

    Yagi T, S. Wakasa, N. Tokunaga, Y. Akimoto, M. Umezu

    Proceedings of 10th international conference on fluid control, measurements, and visualization    2009  [Refereed]

  • 3D volume visualization for vascular flow modeling using stereo PIV with fluorescent tracer particles

    Yagi T, Kamoda A, Yang W, Umezu M

    Proceedings of the 8th international symposium on particle image velocimetry    2009  [Refereed]

  • In vitro study of the 3D vortical flow structure in the sinus of Valsalva using multiplane scanning stereo PIV: implication for coronary circulation

    Yagi T, Yang W, Wakasa S, Umezu M

    Proceedings of the 13th International Symposium on Flow Visualization    2008  [Refereed]

  • 走査型ステレオPIV法を用いた異なる大動脈バルサルバ洞形状をもつ Valved Graft 内の3次元流動特性

    八木高伸, 若狭翔太郎, William Yang, 岩清隆, 梅津光生

    日本機械学会創立110周年記念2007年度年次大会講演論文集   5   295 - 296  2007.09

  • Coil compaction予測のための時系列PIV法を用いた実形状弾性脳動脈瘤モデル内の流れの可視化

    松本徹, 岩清隆, 八木高伸, 福島桃子, 鴨田明憲, 梅津光生, 阿久津敏乃介, 高尾洋之, 石橋敏寛, 村山雄一

    第19回バイオエンジニアリング講演会 講演論文集     82 - 83  2007.01

  • ステレオPIV法を用いた大動脈バルサルバ洞内の3次元流れ場構造に関する基礎知識

    須藤宏幸, 八木高伸, 石川大輔, 若狭翔太朗, William Yang, 岩清隆, 梅津光生

    第19回バイオエンジニアリング講演会 講演論文集     62 - 63  2007.01

  • リアルタイム周波数解析を用いた人工弁閉鎖時に発達する瞬時高周波ストレスの検討

    石川大輔, 八木高伸, 須藤宏幸, 若狭翔太朗, 阿久津敏乃介, 岩清隆, 梅津光生

    第19回バイオエンジニアリング講演会 講演論文集     60 - 61  2007.01

  • Numerical and experimental study on the vortex flow structure inside a spiral vortex ventricular assist device

    Cheung S, Tu JY, Yagi T, Yang W, Umezu M

    Journal of Biomechanics   40 ( S2 ) S478  2007  [Refereed]

  • Three-dimensional fluid mechanics of the sinus of Valsalva with a bileaflet mechanical heart valve

    Takanobu Yagi, Daisuke Ishikawa, Hiroyuki Sudo, Shotaro Wakasa, William Yang, Kiyotaka Iwasaki, Mitsuo Umezu

    PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007     187 - 188  2007  [Refereed]

  • Real-time planar spectral analysis of instantaneous high-frequency stress on blood cells downstream of an artificial heart valve

    Yagi T, W. Yang, M. Umezu

    Proceedings of the 12th International Symposium on Flow Visualization    2006  [Refereed]

  • Multiplane scanning Stereo-PIV measurements of flow inside a spiral vortex pulsatile blood pump

    Yagi T, Yang W, Ishikawa D, Sudo H, Iwasaki K, Umezu M

    Proceedings of the 13th International Symposium on Applications of Laser Techniques to Fluid Mechanics    2006  [Refereed]

  • 3D quantitative flow visualization of a spiral vortex pulsatile blood pump using Stereoscopic PIV

    Yang W, Yagi T, Ishikawa D, Sudo H, Iwasaki K, Umezu M, Tu JY

    Proceedings of the 12th International Symposium on Flow Visualization    2006  [Refereed]

  • Stereoscopic Particle Image Velocimetry for application in Three-dimensional flow within a Spiral Vortex Pulastile Blood Pump

    Yagi T, Yang W, Ishikawa D, Iwasaki K, Umezu M

    Biocybernetics and Biomedical Engineering   26 ( 1 ) 39 - 48  2006  [Refereed]

  • Stereoscopic particle image velocimetry measurements toward three dimensional flow investigations within the spiral vortex blood pump "jointly worked"

    Yagi T, Yang W, Ishikawa D, Iwasaki K, Umezu M

    Lecture Notes of the ICB Seminar 8th Polish-Japanese Seminar on New Technologies For Future Artificial Organs     106 - 112  2005.08

  • 脳動脈瘤治療法の評価を目的とした拍動循環シミュレータの開発

    栗山仁志, 岩崎清隆, 八木高伸, 高島俊洋, 藤井麻由, 石川大輔, 梅津光生, 阿久津敏乃介, 高尾洋之, 石橋敏寛, 村山雄一

    第17回バイオエンジニアリング講演会 講演論文集     397 - 398  2005.01

  • Stereoscopic PIV measurements on 3D swirling convergent flows inside a Spiral Vortex ventricular assist device

    Yagi T, Yang W, Umezu M

    Proceedings PIV’05, 6th International Symposium on Particle Image Velocimetry    2005  [Refereed]

  • An investigation of instantaneous high-frequency turbulent stress in the vicinity of artificial heart valves using wavelet transform analysis of Dynamic PIV measurements

    Yagi T, Ishikawa D, Sudo H, Akutsu T, Yang W, Iwasaki K, Umezu M

    Proceedings of the IFMBE, The 12th ICBME   12  2005  [Refereed]

  • An experimental investigation of three-dimensional pulsatile flow structures within the Spiral Vortex Ventricular Assist Device using Stereoscopic PIV

    Yagi T, Yang W, Ishikawa D, Sudo H, Iwasaki K, Umezu M

    Proceedings of the IFMBE, The 12th ICBME   12  2005  [Refereed]

  • 人工心臓26題

    梅津 光生, 見藤 歩, 八木 高伸, 岩崎 清隆, 小堀 賢司, 今井 浩二, 福長 一義

    人工臓器   33 ( 2 ) s146 - s148  2004

    DOI CiNii

  • Silicone vascular models for analysis of carotid artery stenting

    Okamoto Y, Inukai H, Kobashi H, Yamaga H, Yagi T, Iwasaki K, Shiurba R, Umezu M

    IFMBE Proceedings   31   398 - 401

    DOI

  • Modeling of fluid flow in a pulsatile artificial blood pump: implication for thrombosis

    YAGI Takanobu

       [Refereed]

  • 人工心臓の血液適合性評価に向けた新可視化技術の基礎検討

    八木 高伸

    早稲田大学    [Refereed]

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Books and Other Publications

  • 基礎からよくわかる実践的CFD（数値流体力学）入門

    八木 高伸( Part： Contributor, 7.3 CFDの論文の書き方ポイント、7.4 数値流体力学を原理から現場へ)

    メディカ出版  2017

  • 次世代診断治療支援のための血流シミュレーション

    八木 高伸( Part： Joint author, 第3章 血流シミュレーションの方法、第5章 血流シミュレーションの結果と解釈、第6章 血流シミュレーションの事例)

    日本機械学会  2016

  • 医療現場のための数値流体力学（全7回）

    八木 高伸( Part： Sole author)

    日本診療放射線技師会誌  2014

Misc

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Industrial Property Rights

  • 血管病の病態再構築に関する方法、疾患モデル及び装置

    八木高伸, 坂口勝久, 亀岡洋一郎

    Patent

  • 漏出検出センサおよび薬液注入システム

    朴栄光, 八木高伸, 小野世一, 川辺朋之, 伊藤達也

    Patent

  • ミキシングデバイス、ミキシングチューブ、薬液注入システム及び薬液の混合方法

    八木高伸, 朴栄光, 梅津光生

    Patent

  • 気管チューブ、膨張性カフ、及び封止部材

    森岡 宣伊, 永井 美玲, 尾崎 眞, 八木 高伸, 石井 裕之, 高西 淳夫, 戸部 泰貴

    Patent

  • 血流性状診断のためのシステム、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

  • 血管内治療シミュレーション装置及び方法

    八木高伸, 星雄陽

    Patent

  • 血管形状分析装置、その方法、及びそのコンピュータソフトウェアプログラム

    八木高伸, 中本将彦

    Patent

  • 病変血流特徴量可視化装置、その方法、及びそのコンピュータソフトウェアプログラム

    八木高伸

    Patent

  • 組織血管特性を可視化するための方法及びその装置

    八木高伸

    Patent

  • 血管病変発症・成長予測装置及び方法

    八木高伸

    Patent

  • 血流解析装置、その方法、及びそのコンピュータソフトウェアプログラム

    八木 高伸

    Patent

  • 漏出検出センサおよび薬液注入システム

    朴栄光, 八木高伸, 小野世一, 川辺朋之, 伊藤達也

    Patent

  • 血管形状構築装置、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 中本将彦, 朴栄光

    Patent

  • 血管治療評価システム、そのコンピュータソフトウエアプログラム及び方法

    八木高伸, 朴栄光

    Patent

  • 血流シミュレーションのための血流解析機器、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

  • 血流シミュレーションのための血流解析機器、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

  • 血流シミュレーションのための血管形状構築装置、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

  • ミキシングデバイス、ミキシングチューブ、薬液注入システム及び薬液の混合方法

    八木高伸, 朴栄光, 梅津光生

    Patent

  • 血流性状診断のためのシステム、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

  • 血管治療効果の血流シュミレーションシステム、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

  • 血管血流シュミレーションシステム、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

  • 血流性状診断のためのシステム、その方法及びコンピュータソフトウエアプログラム

    八木高伸, 朴栄光

    Patent

  • 漏出検出センサおよび薬液注入システム

    朴栄光, 八木高伸, 小野世一, 川辺朋之, 伊藤達也

    Patent

  • ミキシングデバイス、ミキシングチューブ、薬液注入システム及び薬液の混合方法

    八木高伸, 朴栄光, 梅津光生

    Patent

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Awards

  • 優秀ポスター賞銅賞

    2018   日本脳神経血管内治療学会総会   ヒト脳動脈瘤の退行性変化と破裂メカニズムに関する検討

    Winner： 吉田浩貴, 八木高伸, 西谷和敏, 岡田義文, 川村公一, 須藤健太, 梅津光生, 北原茂美

  • 優秀講演フェロー賞

    2017   機械学会バイオフロンティア   ヒト脳動脈瘤破裂因子の特定に向けた病理工学的検討 壁の菲薄化と炎症細胞の関連性

    Winner： 須藤健太, 八木高伸, 王心寧, 川村公一, 梅津光生, 吉田浩貴, 西谷和俊, 岡田義文, 北原茂実

  • Best Poster Award

    2016   ICBME   Proposal of mathematical auto-regulation model for cerebral blood flow rate prediction of cerebral bypass surgery

    Winner： Takanishi K, Yagi T, Umezu M

  • YIA

    2013   ICBME   Relationship between pathology and hemodynamics of human unruptured cerebral aneurysms

    Winner： Tobe Y, Yagi T, Kawamura K, Umezu M

  • 若手研究者支援事業アーリーバード（第二期生）

    2012   早稲田大学   脳血管疾患の診断・治療の新展開：血流診断の実用化に向けた安全性に関する研究

    Winner： 八木 高伸

  • 大会賞

    2012   脳血管内治療学会   CFD 解析とSEM による内皮細胞観察を行ったDistal PICA aneurysm の1 例

    Winner： 吉田浩貴, 八木高伸, 岩崎清隆, 戸部泰貴, 高村兼司, 林 祥史, 西谷和敏, 中島 温, 岡田義文, 菅原道仁, 久保俊朗, 北原茂実

  • Crazy&Incredible賞

    2012   人工心臓懇話会   壁面衝突する個々の赤血球のリアルタイム動態観察と溶血との関連性

    Winner： 八木 高伸

  • Graphics of the year award

    2012   JBSE   Effect of bileaflet valve orientation on the 3D flow dynamics in the sinus of valsalva

    Winner： Yagi T, Yang W, Umezu M

  • Master Student 1st Prize

    2012   ASME   Investigation on a relationship between hemodynamics and wall-thinning in an unruptured human cerebral aneurysm

    Winner： Tobe Y, Yagi T, Umezu M

  • 若手研究者支援事業アーリーバード（第一期生）

    2011   早稲田大学   流体工学が創造する21世紀医療：予測医療の実現に向けた血流マーカーの構築

    Winner： 八木 高伸

  • 会長賞

    2011   日本脳神経外科学会   脳動脈瘤における血流の流体解析と瘤壁の電子顕微鏡所見の相関：瘤壁を菲薄化させる「悪性流れ」の特定に向けて

    Winner： 林祥史, 八木高伸

  • 若手研究者賞

    2009   人工心臓懇話会   高速マイクロジェットを用いた壁面衝突する赤血球の圧縮特性と破壊現象に関する検討

    Winner： 秋元祐紀, 八木高伸, 若狭翔太郎, 徳永夏子, 岩崎清隆, 梅津光生

  • YIA 1st Prize

    2009   WC on Med Phy & BME   Single-cell real-time imaging of flow-induced hemolysis using high-speed microfluidic technology

    Winner： Yagi T, Umezu M

  • YSA

    2006   ISFV   Real-time planar spectral analysis of instantaneous high-frequency stress on blood cells downstream of an artificial heart valve,

    Winner： Yagi T, W. Yang, M. Umezu

  • Outstanding Paper Award

    2005   ICBME   An experimental investigation of three dimensional pulsatile flow structures within the spiral vortex ventricular assist device using Stereoscopic PIV

    Winner： Yagi T, W. Yang, M. Umezu

  • ドクター21

    2004   公益財団法人吉田育英会  

    Winner： 八木 高伸

  • Tau Beta Pi

    2001   The Engineering Honor Society USA  

    Winner： 八木 高伸

▼display all

Research Projects

  • 非臨床性能評価を深化する超小型血液循環シミュレータの開発

    文部科学省  科研費基盤B

    Project Year :

    2018.04
    -
    2021.03
     

    梅津 光生

  • SHG光計測による瞬時大変形した赤血球の膜損傷の可視化と損傷度の定量

    文部科学省  科研費基盤C

    Project Year :

    2018.04
    -
    2021.03
     

    中村 匡徳

  • 新規治療機器を実臨床に導入時に有効な循環シミュレータの開発

    文部科学省  科研費基盤B

    Project Year :

    2015.04
    -
    2018.03
     

    梅津 光生

  • 数値流体力学による冠動脈機能的狭窄の非侵襲診断ソフトウェアの開発

    AMED  Medical Artsの創成に関する研究

    Project Year :

    2016.04
    -
    2017.03
     

    斎藤 成達

  • 数値流体力学による脳動脈瘤血管内治療リスク判定システムの開発

    AMED  医工連携事業化推進事業

    Project Year :

    2016.04
    -
    2017.03
     

    坂田 隆史, 八木 高伸

  • 広領域循環シミュレータによる脳血管血行再建術支援のための血流制御機構の解明

    文部科学省  科研費基盤B

    Project Year :

    2015.04
    -
    2017.03
     

    片岡 大治

  • 数値流体力学による脳動脈瘤発症リスク診断法の開発

    JST  ASTEP FS

    Project Year :

    2015.04
    -
    2016.03
     

    冨永 悌二

  • 血流シミュレータによる治療困難な脳動脈瘤に対するバイパス併用術支援技術の確立

    文部科学省  科研費基盤C

    Project Year :

    2012.04
    -
    2014.03
     

    片岡 大治

  • 循環器系DRYラボセンターを駆使した治療リスクの低減システム構築と人材育成

    厚生労働省  医療機器開発推進研究事業

    Project Year :

    2011.04
    -
    2013.03
     

    梅津 光生

  • 臨床に直接貢献できる実用型小児先天性心疾患の血流シミュレーションシステムの構築

    文部科学省  科研費挑戦的萌芽

    Project Year :

    2009.04
    -
    2010.03
     

    梅津 光生

  • 高速マイクロ流れを用いた赤血球破壊リアルタイム可視化と溶血力学モデルの実験的構築

    文部科学省  科研費若手B

    Project Year :

    2009.04
    -
    2010.03
     

    八木 高伸

  • 循環器系DRYラボセンターの創設とENGINEERING BASED MEDICINEの推進

    厚生労働省  医療機器開発推進研究事業

    Project Year :

    2008.04
    -
    2010.03
     

    梅津 光生

  • -

▼display all

Presentations

  • 数値流体力学（CFD）による冠動脈血流シミュレーション

    八木 高伸  [Invited]

    FRIENDS 

    Presentation date： 2017

  • 数値流体力学（CFD）による心臓，脳血管障害の診断治療支援：現状と展望

    八木 高伸  [Invited]

    日本放射線技術学会近畿支部平成29年度秋季勉強会 

    Presentation date： 2017

  • 医工連携による脳動脈瘤の病態解明―次世代診断治療支援技術を目指して―

    八木 高伸  [Invited]

    第19回中国四国脳卒中研究会 

    Presentation date： 2017

  • Computational Fluid Dynamics for Assisting Neurosurgery: Basic Principles

    八木 高伸  [Invited]

    第13回国際脳卒中外科学会 

    Presentation date： 2017

  • 数値流体力学による脳動脈瘤の血流解析：15年のレビュー

    八木 高伸  [Invited]

    第33回NPO法人日本脳神経血管内治療学会学術総会 

    Presentation date： 2017

  • 数値流体力学による血管障害の診断治療支援：現状と展望

    八木 高伸  [Invited]

    第16回CTテクノロジーフォーラム 

    Presentation date： 2017

  • マイクロ流路を用いた血流停滞と赤血球凝集に関する研究

    鈴木砂良, 八木高伸, 横山孝太, 梅津光生

    第29回バイオエンジニアリング講演会 

    Presentation date： 2017

  • 直線マイクロ流路を用いた高せん断流れ場における血栓形成因子の活性化に関する研究

    横山孝太, 八木高伸, 鈴木砂良, 梅津光生

    第29回バイオエンジニアリング講演会 

    Presentation date： 2017

  • 脳動脈瘤発症メカニズム解明に向けた瘤患者と健常者における血管形態の特徴に関する検討

    村吉大阿, 八木高伸, 戸部泰貴, 梅津光生

    第29回バイオエンジニアリング講演会 

    Presentation date： 2017

  • 脳動脈瘤菲薄メカニズム解明に向けた平滑筋細胞と血行動態の病理工学的検討

    戸部泰貴, 八木高伸, 須藤健太, 王心寧, 川村公一, 梅津光生, 吉田浩貴, 林祥史, 西谷和敏, 岡田義文

    第29回バイオエンジニアリング講演会 

    Presentation date： 2017

  • 脳動脈瘤破裂メカニズム解明に向けた未破裂・破裂瘤における壁厚と壁細胞の病理工学的検討

    須藤健太, 八木高伸, 戸部泰貴, 川村公一, 梅津光生, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂美

    第29回バイオエンジニアリング講演会 

    Presentation date： 2017

  • 脳動脈瘤の発祥解明に向けた瘤発症分岐部と未発症分岐部の病理特徴の検討

    王心寧, 八木高伸, 戸部泰貴, 須藤健太, 吉田浩貴, 林祥史, 西谷和敏, 岡田義文, 北原茂美, 川村公一, 梅津光生

    第29回バイオエンジニアリング講演会 

    Presentation date： 2017

  • 脳虚血患者における脳主幹動脈供給血流量と脳組織需要血流量の関係性の検討

    西条卓人, 八木高伸, 高西清文, 戸部泰貴, 片岡大治, 山本明秀, 井口智史, 飯田秀博, 菅原裕太, 中村匡徳, 梅津光生

    第29回バイオエンジニアリング講演会 

    Presentation date： 2017

  • 脳血管バイパス術患者における壁面せん断応力一定性の検討

    高西清文, 八木高伸, 西条卓人, 戸部泰貴, 山本明秀, 井口智史, 飯田秀博, 中村匡徳, 菅原裕太, 梅津光生

    第29回バイオエンジニアリング講演会 

    Presentation date： 2017

  • ヒト脳動脈瘤の発症メカニズム解明に向けた脳血管分岐部内腔における三次元内膜肥厚分布解析

    王心寧, 須藤健太, 臼井一晃, 亀岡洋一郎, 八木高伸, 川村公一, 梅津光生

    第30回バイオエンジニアリング講演会 

    Presentation date： 2017

  • マイクロ流路を用いた血流の衝突と血小板凝集の関係性に関する研究

    横山孝太, 八木高伸, 篠崎駿, 梅津光生

    第30回バイオエンジニアリング講演会 

    Presentation date： 2017

  • ヒト脳動脈瘤破裂因子の特定に向けた病理工学的検討：壁の菲薄化と炎症細胞の関連性

    須藤健太, 八木高伸, 王心寧, 川村公一, 梅津光生, 吉田浩貴, 西谷和俊, 岡田義文, 北原茂実

    第28回バイオフロンティア講演会 

    Presentation date： 2017

  • 数値流体力学（CFD）による冠動脈血流シミュレーション

    八木 高伸  [Invited]

    FRIENDS 

    Presentation date： 2016

  • 医工連携による脳動脈瘤病態解明の新展開

    八木 高伸  [Invited]

    東海クモ膜下出血研究会 

    Presentation date： 2016

  • Computational fluid dynamicsの冠循環への応用

    八木 高伸  [Invited]

    POPAI 

    Presentation date： 2016

  • 循環器系疾患のための次世代診断治療支援技術：血流解析シミュレーション

    八木 高伸  [Invited]

    第20回CTサミット 

    Presentation date： 2016

  • 医工学による未来医療：血流を診る

    八木 高伸  [Invited]

    高知大学大学院博士課程医学専攻DCセミナー 

    Presentation date： 2016

  • 医工連携による医療機器開発:工学から医学への期待

    八木 高伸  [Invited]

    第80回日本循環器学会学術集会 日本機械学会ジョイントシンポジウム 

    Presentation date： 2016

  • Stereo PIVを用いた大動脈弁モデル近傍の流れ場の可視化手法の開発

    高橋東, 須藤健太, 戸部康貴, 松橋祐輝, 鈴木砂良, 八木高伸, 佐々木崇史, 滝沢研二

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • 健常者の脳血管形状を用いた脳動脈瘤好発部位における血流の特徴に関する検討

    村吉大阿, 八木高伸, 戸部泰貴, 杉浦拓磨, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • 血管吻合形状のモデル化とエネルギー損失値との関係性に関する検討

    尾山大輔, 朴栄光, 八木高伸, 岩崎清隆, 小坂眞一, 梅津光生

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • マイクロ流路を用いた血流の衝突と血栓形成因子の活性化に関する研究

    手塚諒, 八木高伸, 衛冉, 梅津光生

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • 健常者脳主幹動脈における壁面せん断応力一定性の検討

    高西清文, 八木高伸, 渡邊幹彦, 梅津光生, 中村匡徳, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • 脳血行再建術前後における需要血流量と供給血流量の関係性

    渡邊幹彦, 八木高伸, 高西清文, 片岡大治, 山本明秀, 井口智史, 飯田秀博, 中村匡徳, 梅津光生

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • ヒト未破裂脳動脈瘤の病理的工学研究：壁性状に応じた泡沫細胞分布に関する検討

    須藤健太, 八木高伸, 杉浦拓磨, 戸部泰貴, 川村公一, 梅津光生, 林祥史, 吉田浩貴, 岡田義文, 北原茂実

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • ヒト未破裂脳動脈瘤の病理工学的研究：壁細胞密度による組織再生能に関する検討

    杉浦拓磨, 八木高伸, 戸部泰貴, 須藤健太, 川村公一, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • ヒト脳動脈瘤の病理工学的検討：超微細構造による菲薄化メカニズムに関する検討

    戸部泰貴, 杉浦拓磨, 須藤健太, 八木高伸, 川村公一, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

    第28回バイオエンジニアリング講演会 

    Presentation date： 2016

  • Modeling of blood flow with pathology in cerebral aneurysms

    Yagi T, Tobe Y, Hayashi Y, Kawamura K, Umezu M

    Interdisciplinary Cerebrovascular Symposium Intracranial Stent Meeting 

    Presentation date： 2015

  • 血流解析専用ソフトウェアによる未来医療への挑戦 CFDを原理から現場へ

    八木 高伸  [Invited]

    第30回日本脳神経血管内治療学会ランチョンセミナー 

    Presentation date： 2015

  • 血流を診る未来医療の創造 CFD を原理から現場へ

    八木 高伸  [Invited]

    第46回神奈川アンギオ撮影研究会 

    Presentation date： 2015

  • オールジャパンで共創する脳動脈瘤の未来医療と技術革新

    八木 高伸  [Invited]

    脳血管外科フォーラム 

    Presentation date： 2015

  • 脳動脈瘤における流体解析の最前線

    八木 高伸  [Invited]

    第39回兵庫県CT部会 

    Presentation date： 2014

  • 脳動脈瘤の血流を診る：原理から現場へ

    八木 高伸  [Invited]

    第14回高速らせんCT技術セミナー 

    Presentation date： 2014

  • 血流解析専用ソフトウェアによる未来医療への挑戦：CFDを原理から現場へ

    八木 高伸  [Invited]

    日本脳神経血管内治療学会ランチョンセミナー 

    Presentation date： 2014

  • 化学発光を用いた溶血現象の可視化手法の検討

    梅谷康太郎, 八木高伸, 中村匡徳, 岩本理沙, 手塚諒, 梅津光生

    第26回バイオエンジニアリング講演会 

    Presentation date： 2014

  • 衝撃せん断流によるヒト赤血球破壊に関する検討

    岩本理沙, 八木高伸, 梅谷康太郎, 手塚諒, 梅津光生

    第26回バイオエンジニアリング講演会 

    Presentation date： 2014

  • CFD流出境界条件の違いが脳動脈瘤内血流に及ぼす影響の検討

    山梨桃子, 八木高伸, 平口心, 三登将平, 高村兼司, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

    第26回バイオエンジニアリング講演会 

    Presentation date： 2014

  • 脳血管バイパス術における術前・術後の血行動態に関する検討

    高村兼司, 八木高伸, 山梨桃子, 片岡大治, 山本明秀, 井口智史, 飯田秀博, 佐藤洸太, 中村匡徳, 梅津光生

    第26回バイオエンジニアリング講演会 

    Presentation date： 2014

  • 脳動脈瘤の発生初期とされる分岐血管壁の菲薄化と血行動態に関する検討

    岩渕祐貴, 八木高伸, 戸部泰貴, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

    第26回バイオエンジニアリング講演会 

    Presentation date： 2014

  • 流体力学によるテイラーメイド診断治療支援：現状と将来

    八木 高伸  [Invited]

    心臓 CT セミナー 

    Presentation date： 2013

  • 血流を診る医療へ：数値流体力学（CFD)を原理から現場へ

    八木 高伸  [Invited]

    医工融合最新技術動向セミナー神戸 

    Presentation date： 2013

  • 体循環シミュレータを用いたステントレス僧帽弁の開閉特性に関する検討

    真鍋晋, 八木高伸, 岩﨑清隆, 加瀬川均, 梅津光生

    第24回バイオフロンティア講演会 

    Presentation date： 2013

  • ヒト未破裂脳動脈瘤の瘤壁の菲薄化を術前に検知できる血流の指標化に関する検討

    岩渕祐貴, 八木高伸, 戸部泰貴, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

    第24回バイオフロンティア講演会 

    Presentation date： 2013

  • 循環シミュレータを用いた心不全患者への補助人工心臓装着による治療効果の検討

    岡田昂大, ムンソジョン, 土居徹哉, 五十嵐利博, 山崎健二, 八木高伸, 岩﨑清隆, 藤本哲男, 梅津光生

    第24回バイオフロンティア講演会 

    Presentation date： 2013

  • ３分岐人工血管の非臨床試験における血流配分評価法の検討

    木浦千夏子, 八木高伸, 中村匡徳, 岩崎清隆, 銭逸, 奥田茂男, 吉武明弘, 志水秀行, 四津良平, 梅津光生

    第51回日本人工臓器学会大会/第5回国際人工臓器学術大会 

    Presentation date： 2013

  • 赤血球の伸長に応じた衝突・破壊特性

    八木高伸, 岩本理沙, 梅谷康太郎, 手塚諒, 梅津光生

    第51回日本人工臓器学会大会/第5回国際人工臓器学術大会 

    Presentation date： 2013

  • 医工融合で加速する脳血管疾患の診断・治療の新展開：血流診断

    八木 高伸

    MEIOS特別セミナー 

    Presentation date： 2012

  • 流体力学で診る未破裂脳動脈瘤の術前壁性状予測

    八木 高伸  [Invited]

    Non Invasive Imaging Seminar 

    Presentation date： 2012

  • 流体力学が挑む次世代医療への挑戦：流れの現実と解釈

    八木 高伸  [Invited]

    日本機械学会東海学生会第190回講演会 

    Presentation date： 2012

  • ヒト脳動脈瘤の外壁性状及び衝突流れの相関による組織菲薄化に関する検討

    戸部泰貴, 八木高伸, 高橋彩来, 岩渕裕貴, 山梨桃子, 岩崎清隆, 梅津光生, 林祥史, 岡田義文, 菅原道仁, 北原茂実

    第24回バイオエンジニアリング講演会 

    Presentation date： 2012

  • EFDとCFDの比較による脳動脈瘤内の血流の衝突ダイナミクスに関する研究

    高橋彩来, 八木高伸, 戸部泰貴, 岩淵裕貴, 山梨桃子, 岩崎清隆, 梅津光生, 村山雄一, 高尾洋之

    第24回バイオエンジニアリング講演会 

    Presentation date： 2012

  • 個々の赤血球の細胞内ヘモグロビン総量を画像計測する方法に関する基礎検討

    関裕子, 八木高伸, 木田大輔, 岩本理沙, 梅津光生

    第24回バイオエンジニアリング講演会 

    Presentation date： 2012

  • 壁面衝突する個々の赤血球のリアルタイム動態観察と溶血との関連性

    八木 高伸

    第40回人工心臓と補助循環懇話会 

    Presentation date： 2012

  • 循環器系人工臓器のマクロ・マイクロ流体解析：血液破壊を予防する次世代人工臓器を目指して

    八木 高伸  [Invited]

    先端技術フォーラム，日本機械学会2011年度年次大会 

    Presentation date： 2011

  • 脳動脈瘤の破裂を予測する医工学技術の確立に向けて

    八木 高伸  [Invited]

    墨田区産学連携事業 

    Presentation date： 2011

  • 血流解析による脳動脈瘤のテイラーメイド診断：破裂瘤の予測・予防を目指して

    八木 高伸  [Invited]

    Japan ANSYS Conference 

    Presentation date： 2011

  • 未破裂脳動脈瘤の次世代医療：血流診断による破裂瘤の予測・予防戦略

    八木 高伸  [Invited]

    早稲田大学理工学術院 総合研究所産学連携室 先端研究者交流会第一回会合 

    Presentation date： 2011

  • 弾性脳動脈瘤モデルを用いたステレオＰＩＶ法による壁面せん断応力3次元計測と時間・空間特性

    新家学, 八木高伸, 梅津光生

    第23回バイオエンジニアリング講演会 

    Presentation date： 2011

  • 超高速イメージングによる衝突速度に応じたヒト赤血球のリアルタイム破壊動態解析

    秋元祐紀, 八木高伸, 梅津光生

    第23回バイオエンジニアリング講演会 

    Presentation date： 2011

  • 脳動脈瘤内の流れの遷移性に関して：計測・計算の比較によるモデリング留意点

    八木高伸, 高橋彩来, 戸部泰貴, 岩崎清隆, 梅津光生, 高尾洋之, 村山雄一

    第34回日本バイオレオロジー学会年会 

    Presentation date： 2011

  • 脳動脈瘤における血流の流体解析と瘤壁の電子顕微鏡所見の相関：瘤壁を菲薄化させる「悪性流れ」の特定に向けて

    林祥史, 八木高伸, 梅津光生

    第70回日本脳神経外科学会総会 

    Presentation date： 2011

  • 循環器系DRYラボによるもう一つのEBM：Engineering Based Medicine東京女子医大・早稲田大学連携研究施設（TWIns）での事例紹介

    八木 高伸  [Invited]

    マテリアライズカンファレンス 

    Presentation date： 2010

  • 壁面衝突により座屈を伴い瞬時膜破壊に至る赤血球破壊のリアルタイム可視化計測

    徳永夏子, 八木高伸, 秋元祐紀, 関裕子, 梅津光生

    第22回バイオエンジニアリング講演会 

    Presentation date： 2010

  • 破裂脳動脈瘤内の血流に関するマイクロスケール時空間解析：衝突ジェットによる乱流の発生

    佐藤絢香, 八木高伸, 新家学, 高橋彩来, 梅津光生, 村山雄一, 高尾洋之

    第22回バイオエンジニアリング講演会 

    Presentation date： 2010

  • OPCAB吻合手技訓練装置“BEAT-S1”の開発と臨床現場への展開

    朴栄光, 牧野穂高, 新家学, 八木高伸, 浅野竜太, 津久井宏行, Robert L Kormos, 梅津光生

    第22回バイオエンジニアリング講演会 

    Presentation date： 2010

  • 補助人工心臓駆動下における心壁挙動が左心室モデル内血流に及ぼす影響の検討

    久米嶺, 楠瀬俊祐, 立田良太, 五十嵐利博, 八木高伸, 岩崎清隆, 山崎健二, 梅津光生

    第22回バイオエンジニアリング講演会 

    Presentation date： 2010

  • 補助人工心臓駆動下における左心室内の血流の検討~in vitro試験による血流の可視化実験~

    五十嵐利博, 石澤祐馬, 久米嶺, 楠瀬俊祐, 立田良太, 八木高伸, 岩崎清隆, 銭逸, 山崎健二, 梅津光生

    第47回日本人工臓器学会大会 

    Presentation date： 2009

  • 高速リアルタイムイメージングによる壁面衝突する個々の赤血球の衝撃・破壊解析

    八木高伸, 徳永夏子, 秋元祐紀, 関裕子, 梅津光生

    第47回日本人工臓器学会大会 

    Presentation date： 2009

  • 高速マイクロジェットを用いた壁面衝突する赤血球の圧縮変形と破壊現象の可視化計測

    八木高伸, 若狭翔太郎, 徳永夏子, 秋元祐紀, 梅津光生

    計算工学講演会 

    Presentation date： 2009

  • Microfluidic analysis of erythrocyte deformation for studying flow-induced hemolysis

    Yagi T, Sudo H, Akimoto Y, Umezu M

    The International Journal of Artificial Organs 

    Presentation date： 2008

  • 走査型ステレオPIV法を用いた異なる大動脈バルサルバ洞形状をもつValved Graft内の3次元流動特性

    八木高伸, 若狭翔太郎, William Yang, 岩崎清隆, 梅津光生

    日本機械学会年次大会講演論文集 

    Presentation date： 2007

  • Coil compaction予測のための時系列PIV法を用いた実形状弾性脳動脈瘤モデル内の流れの可視化

    松本徹, 岩崎清隆, 八木高伸, 梅津光生

    第19回バイオエンジニアリング講演会 

    Presentation date： 2007

  • ステレオPIV法を用いた大動脈バルサルバ洞内の3次元流れ場構造に関する基礎検討

    須藤宏幸, 八木高伸, 石川大輔, 若狭翔太朗, Yang W, 岩崎清隆, 梅津光生

    第19回バイオエンジニアリング講演会 

    Presentation date： 2007

  • リアルタイム周波数解析を用いた人工弁閉鎖時に発達する瞬時高周波ストレスの検討

    石川大輔, 八木高伸, 阿久津敏乃介, 岩崎清隆, 梅津光生

    第19回バイオエンジニアリング講演会 

    Presentation date： 2007

  • 拍動型人工心臓内の流体構造連成を考慮した旋回流の3次元可視化解析

    八木高伸, William Yang, 若狭翔太朗, 岩崎清隆, 梅津光生

    第18回バイオフロンティア講演会 

    Presentation date： 2007

  • 人工弁近傍の乱流が血球細胞に与える力学的負荷の特性評価

    須藤宏幸, 八木高伸, 阿久津敏乃介, 岩崎清隆, 梅津光生

    第18回バイオフロンティア講演会 

    Presentation date： 2007

  • Three-dimensional volume characterization of swirling flow with fluid-structure coupling in a spiral vortex pulsatile blood pump

    Yagi T, Wakasa S, Yang W, Iwasaki K, Umezu M

    45th JSAO&IFAO Joint Congress 

    Presentation date： 2007

  • The mechanism of turbulence: new finding of impulsively-generated compressive mechanical stress on blood cells flowing through artificial heart valves,

    Yagi T, Sudo H, Akutsu T, Iwasaki K, Umezu M

    45th JSAO&IFAO Joint Congress 

    Presentation date： 2007

  • 中大脳動脈瘤のCFDを用いた血流比変化における動脈瘤内圧変化の検討

    高尾洋之, 村山雄一, 福井弘一, 銭逸, 石橋敏寛, 北谷優太郎, 八木高伸, 岩崎清隆, 梅津光生, 阿部俊昭

    第23回日本脳神経血管内治療学会総会 

    Presentation date： 2007

  • 実形状・弾性モデルを用いた脳動脈瘤内の流れのリアルタイム解析：破裂瘤と未破裂瘤の流入形態の比較検討

    福島桃子, 岩崎清隆, 八木高伸, 鴨田明憲, 佐藤絢香, 梅津光生, 阿久津敏之介, 高尾洋之, 石橋敏寛, 村山雄一

    第23回日本脳神経血管内治療学会総会 

    Presentation date： 2007

  • 脳動脈瘤の医学的問題点とバイオエンジニアリングを用いた研究の期待

    高尾洋之, 村山雄一, 石橋敏寛, 八木高伸, 岩崎清隆, 銭逸, 梅津光生

    適応医学 

    Presentation date： 2006

  • 時系列PIV及びウェーブレット解析を応用した人工弁近傍の高せん断乱流場で発達する瞬時高周波ストレスに関する検討

    石川大輔, 八木高伸, 須藤宏幸, 阿久津敏乃介, 岩﨑清隆, 梅津光生

    第18回バイオエンジニアリング講演会 

    Presentation date： 2006

  • ステレオPIV法を用いたSpiral Vortex型人工心臓内の拍動流の3次元可視化解析

    八木高伸, William Yang, 石川大輔, 須藤宏幸, 岩﨑清隆, 梅津光生

    第18回バイオエンジニアリング講演会 

    Presentation date： 2006

  • 脳動脈瘤治療法の評価を目的とした拍動循環シミュレータの開発

    栗山仁志, 岩崎清隆, 八木高伸, 高島俊洋, 藤井麻由, 石川大輔, 梅津光生, 阿久津敏乃介, 高尾洋之, 石橋敏寛, 村山雄一

    第17回バイオエンジニアリング講演会 

    Presentation date： 2005

  • 人工弁近傍で発達する乱流に関する新評価手法の提言：時系列PIVとWavelet解析を用いた瞬時ストレスの周波数解析

    八木高伸, 石川大輔, 須藤宏幸, 阿久津敏乃介, William Yang, 岩崎清隆, 梅津光生

    第43回日本人工臓器学会 

    Presentation date： 2005

  • Spiral Vortex型人工心臓内の拍動流の3次元構造を実験計測するステレオPIV法の開発

    八木高伸, William Yang, 石川大輔, 須藤宏幸, 岩崎清隆, 梅津光生

    第43回日本人工臓器学会 

    Presentation date： 2005

  • Development of Dynamic Particle Image Velocimetry toward the study of spatio-temporal dynamics of turbulent flow in artificial heart valves

    Yagi T, Ishikawa D, Akutsu T, Iwasaki K, Noguchi Y, Umezu M

    International journal of artificial organs 

    Presentation date： 2004

  • Stereoscopic Particle Image Velocimetry measurements toward three dimensional flow investigations within the Spiral Vortex blood pump

    Yagi T, Yang W, Ishikawa D, Iwasaki K, Umezu M

    lecture notes of the ICB seminar, 7th Polish-Japanese seminar on new technologies for future artificial organs 

    Presentation date： 2004

  • Spiral Vortex型血液ポンプ内の3次元流れ解析に向けて－PIV可視化解析及び数値流体モデルによる検討

    八木高伸, William Yang, 長沼寛樹, 佐藤芳行, 岩崎清隆, 梅津光生

    第16回バイオエンジニアリング講演会 

    Presentation date： 2004

  • 拍動型人工心臓内の流れ場の3次元構造および時系列現象を計測する新可視化技術の基礎検討

    八木高伸, 石川大輔, William Yang, 阿久津敏乃介, 岩崎清隆, 野口康雄, 梅津光生

    第42回日本人工臓器学会 

    Presentation date： 2004

  • Dynamic and static evaluation of two types of annuloplasty rings at mitral position using a mock circuit with fresh porcine valve

    Umezu M, Iwasaki K, Arita M, Okuda M, Doi H, Yagi T, Kasegawa H, Fujimoto T

    30th ESAO congress 2003 High tech and medicine 

    Presentation date： 2003

  • Development of an In Vitro Evaluation System for Mitral Annuloplasty, World Congress on Medical Physics and Biomedical Engineering

    Doi H, Arita M, Okuda M, Yagi T, Iwasaki K, Umezu M

    World Congress on Medical Physics and Biomedical Engineering 

    Presentation date： 2003

  • Development of a multi-purpose mock circulatory system to reproduce a mitral valve disease

    Okuda M, Arita M, Doi H, Yagi T, Kasegawa H, Umezu M, Tanaka T

    Asian Simulation Conf. the 5th International Conference on System Simulation and Scientific Computing 

    Presentation date： 2002

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Syllabus

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Teaching Experience

  • 医用機械工学研究

    早稲田大学  

  • 臨床医工学概論

    早稲田大学  

  • 臓器工学特論

    早稲田大学  

  • フルーイドダイナミクス

    早稲田大学  

  • メカニカルエンジニアリングラボ

    早稲田大学  

 

Committee Memberships

  • 2018.07
    -
    Now

    脳血管CFD解析実用化委員会  事務局

  • 2018.04
    -
    Now

    日本放射線技術学会  医用画像標準化委員

  • 2016.04
    -
    Now

    日本機械学会バイオエンジニアリング  講習会講師

  • 2016.04
    -
    Now

    日本機械学会バイオエンジニアリング  運営委員会

  • 2015.04
    -
    Now

    日本バイオレオロジー学会  企画小委会血管内治療

  • 2015.04
    -
    Now

    日本バイオレオロジー学会  広報委員会委員

  • 2013.04
    -
    Now

    日本バイオレオロジー学会  評議員

  • 2015.04
    -
    2016.03

    FLUCOME  Int. Steering Committee member

  • 2014.06
    -
    2015.05

    可視化情報学会  講習会実行委員長

  • 2012.04
    -
    2013.03

    日本機械学会バイオエンジニアリング  広報委員会

  • 2011.04
    -
    2012.03

    可視化情報学会  シンポジウム大会幹事

  • 2011.04
    -
    2012.03

    可視化情報学会  学会誌委員幹事

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