Details of a Researcher - YAGI, Takanobu

写真a

YAGI, Takanobu

Scopus Paper Info

Paper Count: 29 Citation Count: 171 h-index: 7

Click to view the Scopus page. The data was downloaded from Scopus API in April 18, 2024, via http://api.elsevier.com and http://www.scopus.com .

Affiliation

Faculty of Science and Engineering, Waseda Research Institute for Science and Engineering

Job title

Researcher(Associate Professor)

Degree

博士（工学） ( 早稲田大学 )

Research Experience

2018.04

-

Now

Tokyo Women's Medical University
2018.04

-

Now

Waseda University Faculty of Science and Engineering
2017.04

-

2018.03

Waseda University Faculty of Science and Engineering
2013.04

-

2017.06

イービーエム株式会社血流解析事業部部長
2014.04

-

2017.03

Waseda University Faculty of Science and Engineering
2013.04

-

2014.03

Waseda University Faculty of Science and Engineering
2011.04

-

2013.03

Waseda University Faculty of Science and Engineering
2009.04

-

2011.03

早稲田大学先進理工学研究科GCOE 研究助手
2007.10

-

2010.09

CSIRO, Australia Advanced Laser Diagnostic Fluid Dynamics Laboratory Visiting Research Associate
2007.10

-

2009.03

Waseda University Faculty of Science and Engineering Waseda Research Institute for Science and Engineering Research Associate

▼display all

Education Background

2004.10

-

2007.09

Waseda University
2004.04

-

2007.04

豪州国立研究所CSIRO 先端流体計測研究室
2003.04

-

2004.09

Waseda University
1997.04

-

2002.03

Waseda university Science and Engineering Dept of Mechanical Engineering
2000.08

-

2001.08

California State University

Committee Memberships

2018.07

-

Now

脳血管CFD解析実用化委員会事務局
2018.04

-

Now

日本放射線技術学会医用画像標準化委員
2016.04

-

Now

日本機械学会バイオエンジニアリング講習会講師
2016.04

-

Now

日本機械学会バイオエンジニアリング運営委員会
2015.04

-

Now

日本バイオレオロジー学会企画小委会血管内治療
2015.04

-

Now

日本バイオレオロジー学会広報委員会委員
2013.04

-

Now

日本バイオレオロジー学会評議員
2015.04

-

2016.03

FLUCOME Int. Steering Committee member
2014.06

-

2015.05

可視化情報学会講習会実行委員長
2012.04

-

2013.03

日本機械学会バイオエンジニアリング広報委員会
2011.04

-

2012.03

可視化情報学会シンポジウム大会幹事
2011.04

-

2012.03

可視化情報学会学会誌委員幹事

▼display all

Professional Memberships

　

　

　

JAPANESE SOCIETY OF RADIOLOGICAL TECHNOLOGY
　

　

　

THE VISUALIZATION SOCIETY OF JAPAN
　

　

　

JAPANESE SOCIETY OF BIORHEOLOGY
　

　

　

THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

Research Areas

Human pathology / Medical technology assessment / Cell biology / Fluid engineering / Neurosurgery / Experimental pathology / Biomaterials / Biomedical engineering

Research Interests

Thrombosis
Hemolysis
Cell death
Biomechanics
cellular interactions
Diagnositc and treatment assisting technology
Medical device R&D
Carotid plaque
Optical imaging
Tissue culture technique R&D
Pathology
Atherosclerosis
Cerebral Aneurysm
Microfluidics
Blood flow dynamics
Vascular Remodeling

▼display all

Awards

優秀ポスター賞銅賞

2018 日本脳神経血管内治療学会総会ヒト脳動脈瘤の退行性変化と破裂メカニズムに関する検討

Winner：吉田浩貴, 八木高伸, 西谷和敏, 岡田義文, 川村公一, 須藤健太, 梅津光生, 北原茂美
優秀講演フェロー賞

2017 機械学会バイオフロンティアヒト脳動脈瘤破裂因子の特定に向けた病理工学的検討壁の菲薄化と炎症細胞の関連性

Winner：須藤健太, 八木高伸, 王心寧, 川村公一, 梅津光生, 吉田浩貴, 西谷和俊, 岡田義文, 北原茂実
Best Poster Award

2016 ICBME Proposal of mathematical auto-regulation model for cerebral blood flow rate prediction of cerebral bypass surgery

Winner： Takanishi K, Yagi T, Umezu M
YIA

2013 ICBME Relationship between pathology and hemodynamics of human unruptured cerebral aneurysms

Winner： Tobe Y, Yagi T, Kawamura K, Umezu M
若手研究者支援事業アーリーバード（第二期生）

2012 早稲田大学脳血管疾患の診断・治療の新展開：血流診断の実用化に向けた安全性に関する研究

Winner：八木高伸
大会賞

2012 脳血管内治療学会 CFD 解析とSEM による内皮細胞観察を行ったDistal PICA aneurysm の1 例

Winner：吉田浩貴, 八木高伸, 岩崎清隆, 戸部泰貴, 高村兼司, 林祥史, 西谷和敏, 中島温, 岡田義文, 菅原道仁, 久保俊朗, 北原茂実
Crazy&Incredible賞

2012 人工心臓懇話会壁面衝突する個々の赤血球のリアルタイム動態観察と溶血との関連性

Winner：八木高伸
Graphics of the year award

2012 JBSE Effect of bileaflet valve orientation on the 3D flow dynamics in the sinus of valsalva

Winner： Yagi T, Yang W, Umezu M
Master Student 1st Prize

2012 ASME Investigation on a relationship between hemodynamics and wall-thinning in an unruptured human cerebral aneurysm

Winner： Tobe Y, Yagi T, Umezu M
若手研究者支援事業アーリーバード（第一期生）

2011 早稲田大学流体工学が創造する21世紀医療：予測医療の実現に向けた血流マーカーの構築

Winner：八木高伸
会長賞

2011 日本脳神経外科学会脳動脈瘤における血流の流体解析と瘤壁の電子顕微鏡所見の相関：瘤壁を菲薄化させる「悪性流れ」の特定に向けて

Winner：林祥史, 八木高伸
若手研究者賞

2009 人工心臓懇話会高速マイクロジェットを用いた壁面衝突する赤血球の圧縮特性と破壊現象に関する検討

Winner：秋元祐紀, 八木高伸, 若狭翔太郎, 徳永夏子, 岩崎清隆, 梅津光生
YIA 1st Prize

2009 WC on Med Phy & BME Single-cell real-time imaging of flow-induced hemolysis using high-speed microfluidic technology

Winner： Yagi T, Umezu M
YSA

2006 ISFV Real-time planar spectral analysis of instantaneous high-frequency stress on blood cells downstream of an artificial heart valve,

Winner： Yagi T, W. Yang, M. Umezu
Outstanding Paper Award

2005 ICBME An experimental investigation of three dimensional pulsatile flow structures within the spiral vortex ventricular assist device using Stereoscopic PIV

Winner： Yagi T, W. Yang, M. Umezu
ドクター21

2004 公益財団法人吉田育英会

Winner：八木高伸
Tau Beta Pi

2001 The Engineering Honor Society USA

Winner：八木高伸

▼display all

Papers

Predicting the growth of middle cerebral artery bifurcation aneurysms using differences in the bifurcation angle and inflow coefficient

Takeshi Miyata, Hiroharu Kataoka, Kampei Shimizu, Akihiro Okada, Takanobu Yagi, Hirotoshi Imamura, Masaomi Koyanagi, Ryota Ishibashi, Masanori Goto, Nobuyuki Sakai, Taketo Hatano, Masaki Chin, Koichi Iwasaki, Susumu Miyamoto

JOURNAL OF NEUROSURGERY 138 ( 5 ) 1357 - 1365 2023.05

　View Summary

OBJECTIVE Growing intracranial aneurysms (IAs) are prone to rupture. Previous cross-sectional studies using postrupture morphology have shown the morphological or hemodynamic features related to IA rupture. Yet, which morphological or hemodynamic differences of the prerupture status can predict the growth and rupture of smaller IAs remains unknown. The purpose of this longitudinal study was to investigate the effects of morphological features and the hemodynamic environment on the growth of IAs at middle cerebral artery (MCA) bifurcations during the follow-up period.METHODS One hundred two patients with MCA M1-2 bifurcation saccular IAs who underwent follow-up for more than 2 years at the authors' institutions between 2011 and 2019 were retrospectively identified. During the follow-up period, cases involving growth of MCA IAs were assigned to the event group, and those with MCA IAs unchanged in size were assigned to the control group. The morphological parameters examined were aneurysmal neck length, dome height, aspect ratio and volume, M1 and M2 diameters and their ratio, and angle configurations among M1, M2, and the aneurysm. Hemodynamic parameters were flow rate and wall shear stress in M1, M2, and the aneurysm, including the aneurysmal inflow rate coef- ficient (AIRC), defined as the ratio of the aneurysmal inflow rate to the M1 flow rate. Those parameters were compared sta- tistically between the two groups. Correlations between morphological and hemodynamic parameters were also examined. RESULTS Eighty-three of 102 patients were included: 25 with growing MCA IAs (event group) and 58 with stable MCA IAs (control group). The median patient age at initial diagnosis was 66.9 (IQR 59.8-72.3) years. The median follow-up period was 48.5 (IQR 36.5-65.6) months. Both patient age and the AIRC were significant independent predictors of the growth of MCA IAs. Moreover, the AIRC was strongly correlated with sharper bifurcation and inflow angles, as well as wider inclination angles between the M1 and M2 arteries. CONCLUSIONS The AIRC was a significant independent predictor of the growth of MCA IAs. Sharper bifurcation and inflow angles and wider inclination angles between the M1 and M2 arteries were correlated with the AIRC. MCA IAs with such a bifurcation configuration are more prone to grow and rupture.

DOI

Scopus
Vascular responses to abrupt blood flow change after bypass surgery for complex intracranial aneurysms.

Kataoka H, Makino Y, Takanishi K, Kimura Y, Takamura K, Yagi T, Iguchi S, Yamamoto A, Iida H, Ogata S, Nishimura K, Nakamura M, Umezu M, Iihara K, Takahashi JC

Acta neurochirurgica 160 ( 10 ) 1945 - 1953 2018.10 [Refereed]

DOI PubMed

Scopus

2

Citation

(Scopus)
Hemodynamic features of offending vessels at neurovascular contact in patients with trigeminal neuralgia and hemifacial spasm.

Satoh T, Yagi T, Onoda K, Kameda M, Sasaki T, Ichikawa T, Date I

Journal of neurosurgery 1 - 7 2018.07 [Refereed] [International journal]

　View Summary

OBJECTIVEOffending vessels at the site of neurovascular contact (NVC) in patients with trigeminal neuralgia (TN) and hemifacial spasm (HFS) may have specific hemodynamic features. The purpose of this study was to investigate the wall shear stress (WSS) of offending vessels at NVCs by conducting a computational fluid dynamics (CFD) analysis.METHODSThe authors retrospectively analyzed the cases of 20 patients (10 with TN and 10 with HFS) evaluated by 3D CT angiography and used the imaging findings for analysis of the hemodynamic parameters. The 3D CFD images were directly compared with the NVCs determined by simulated multifusion images of CT angiogram and MR cisternogram, and operative photos. The magnitudes of the WSS (WSSm) at the proximal (WSSm-p), just-beginning (WSSm-j), contact site (WSSm-s), and distal (WSSm-d) areas of each NVC were analyzed. The ratios of the WSSm-j, WSSm-s, and WSSm-d areas to the WSSm-p area were calculated individually. The direction of the WSS (WSSv) and its temporal variation (WSSvV) were depicted and morphologically compared with the NVC confirmed by simulated images and operative findings.RESULTSThe ratios of WSSm at the just-beginning and the contact site to the proximal area of the NVCs (WSSm-j/WSSm-p and WSSm-s/WSSm-p) were both significantly higher than that at the distal area (WSSm-d/WSSm-p) (p < 0.05). The WSSv and WSSvV at the NVCs showed small variation in a single cardiac cycle, especially along the areas that were in contact with the affected nerve.CONCLUSIONSAreas of relatively high WSSm and temporal variation of WSSm (WSSmV) were observed at the NVCs. Less mobility of the WSSv and WSSvV was detected along the side of the vessels in contact with the nerves. These findings may be consistent with the actual area of the NVC. Hemodynamic features of the site of NVC can be added to the preoperative simulation for MVD surgery, which may be useful for the diagnosis and treatment planning of TN and HFS.

DOI PubMed

Scopus

7

Citation

(Scopus)
A computational fluid dynamics (CFD) study of WEB-treated aneurysms: Can CFD predict WEB "compression" during follow-up?

Jildaz Caroff, Cristian Mihalea, Valerio Da Ros, Takanobu Yagi, Marta Iacobucci, Leon Ikka, Jacques Moret, Laurent Spelle

JOURNAL OF NEURORADIOLOGY 44 ( 4 ) 262 - 268 2017.07 [Refereed]

　View Summary

Background. - Recent reports have revealed a worsening of aneurysm occlusion between WEB treatment baseline and angiographic follow-up due to "compression" of `the device.
Objective. - We utilized computational fluid dynamics (CFD) in order to determine whether the underlying mechanism of this worsening is flow related.
Methods. - We included data from all consecutive patients treated in our institution with a WEB for unruptured aneurysms located either at the middle cerebral artery or basilar tip. The CFD study was performed using pre-operative 3D rotational angiography. From digital subtraction follow-up angiographies patients were dichotomized into two groups: one with WEB "compression" and one without. We performed statistical analyses to determine a potential correlation between WEB compression and CFD inflow ratio.
Results. - Between July 2012 and June 2015, a total of 22 unruptured middle cerebral artery or basilar tip aneurysms were treated with a WEB device in our department. Three patients were excluded from the analysis and the mean follow-up period was 17 months. Eleven WEBs presented "compression" during follow-up. Interestingly, device "compression" was statistically correlated to the CFD inflow ratio (P=0.018), although not to aneurysm volume, aspect ratio or neck size.
Conclusion. - The mechanisms underlying the worsening of aneurysm occlusion in WEB-treated patients due to device compression are most likely complex as well as multifactorial. However, it is apparent from our pilot study that a high arterial inflow is, at least, partially involved. Further theoretical and animal research studies are needed to increase our understanding of this phenomenon. (C) 2017 Elsevier Masson SAS. All rights reserved.

DOI PubMed

Scopus

26

Citation

(Scopus)
Fluid mechanical interpretation of changes in cerebral vascular peripheral resistance caused by bypass surgery

Masanori NAKAMURA, Yuta SUGAWARA, Kiyofumi TAKANISHI, Akihide YAMAMOTO, Satoshi IGUCHI, Takanobu YAGI, Hiroharu KATAOKA

The Proceedings of Mechanical Engineering Congress, Japan 2017 ( 0 ) J0230201 2017 [Refereed]

DOI
Three-dimensional pathological analysis of cerebral aneurysm initiation

Xinning Wang, Kenta Suto, Takanobu Yagi, Koichi Kawamura, Mitsuo Umezu

Communications in Computer and Information Science 761 95 - 103 2017 [Refereed]

　View Summary

Cerebral aneurysm is known to initiate at the cerebral artery bifurcation. The pathological mechanism of cerebral aneurysm awaits further understanding especially on its initiation. This study sought to elucidate the three-dimensional structure of cerebral vascular bifurcations with and without aneurysms using human cadavers. The two cases had aneurysmal initiations out of total 7 cases. The studied structure was intimal hyperplasia, tunica media and internal elastic lamina, which were recognized by elastica masson staining. The results showed that the non-existence of tunica media and internal elastic lamina was found in the lesion without aneurysm. The non-existence of intimal hyperplasia was only found in the lesion with aneurysm. These data suggest that the formation of intimal hyperplasia may be related with the initiation of aneurysm. We regarded the boundary of existence arteriosclerosis as the position for new arteriosclerosis occurs and thought the direction of new arteriosclerosis grows would influence whether the cerebral aneurysm initiates or not.

DOI

Scopus
1E41 The relationship between demand blood flow and supply blood flow before and after revascularization

WATANABE Mikihiko, YAGI Takanobu, TAKANISHI Kiyofumi, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, IIDA Hidehiro, NAKAMURA Masanori, UMEZU Mitsuo

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2016 ( 0 ) _1E41 - 1_-_1E41-4_ 2016 [Refereed]

　View Summary

Cerebral revascularization is a general surgery for vascular lesions. Operative procedures are decided based on surgeon's experience, however unpredictable complications are still a problem. The aim of our study is to predict complications before operation by identifying the mechanism of cerebral hemodynamics adaptations. It is considered that blood flow is regulated for meeting demand of tissue cells. There is a little study about the relationship between blood flow in cerebral arteries and cerebral demand. In this study, the total of flow rate in both sides internal carotid arteries and basilar artery is 'supply blood flow', and gray matter volume (V_G) and white matter volume (V_W) are multiplied by each literature cerebral blood flow (k_G, k_W) to calculate 'demand blood flow' (V_G・K_G+V_W・K_W). For 14 healthy volunteers and 2 patients (aneurysm and ischemic), the ratio of difference between demand and supply blood flow on the basis of supply values are studied. As the result, difference between supply blood flow and demand blood flow is -11.3% in healthy subjects. In a case of aneurysm, difference rate is low before and after surgery. In a case of ischemic, there is a high difference rate (59.1%). However, difference becomes lower (12.1%) by supply blood flow increase after operation. It is suggested that difference rate is available for diagnosis of ischemic.

DOI CiNii
1E41 The relationship between demand blood flow and supply blood flow before and after revascularization

WATANABE Mikihiko, YAGI Takanobu, TAKANISHI Kiyofumi, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, IIDA Hidehiro, NAKAMURA Masanori, UMEZU Mitsuo

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2016 ( 0 ) _1E41 - 1_-_1E41-4_ 2016 [Refereed]

　View Summary

Cerebral revascularization is a general surgery for vascular lesions. Operative procedures are decided based on surgeon's experience, however unpredictable complications are still a problem. The aim of our study is to predict complications before operation by identifying the mechanism of cerebral hemodynamics adaptations. It is considered that blood flow is regulated for meeting demand of tissue cells. There is a little study about the relationship between blood flow in cerebral arteries and cerebral demand. In this study, the total of flow rate in both sides internal carotid arteries and basilar artery is 'supply blood flow', and gray matter volume (V_G) and white matter volume (V_W) are multiplied by each literature cerebral blood flow (k_G, k_W) to calculate 'demand blood flow' (V_G・K_G+V_W・K_W). For 14 healthy volunteers and 2 patients (aneurysm and ischemic), the ratio of difference between demand and supply blood flow on the basis of supply values are studied. As the result, difference between supply blood flow and demand blood flow is -11.3% in healthy subjects. In a case of aneurysm, difference rate is low before and after surgery. In a case of ischemic, there is a high difference rate (59.1%). However, difference becomes lower (12.1%) by supply blood flow increase after operation. It is suggested that difference rate is available for diagnosis of ischemic.

DOI CiNii
Controlling sheer stress in a suspension culture using coquette, flow for efficient proliferation of HEK 293 cells

Zin N, Sakaguchi K, Haraguchi Y, Yagi T, Shimizu T, Umezu M

Fluid Mechanics Open Access 3 ( 1 ) 2016
Pathological engineering analysis of human unruptured cerebral aneurysms for investigation of relationship between hemodynamic stress and smooth muscle cells

Tobe Y, Yagi T, Kawamura K, Umezu M

Proceedings of the ICBME 2016 28 2016 [Refereed]
Proposal of mathematical auto-regulation model for cerebral blood flow rate prediction of cerebral bypass surgery

Takanishi K, Yagi T, Umezu M

Proceedings of the ICBME 2016 2016 [Refereed]
Study of the consistency of wall shear stress in healthy major human cerebral arteries

Takanishi K, Yagi T, Umezu M

Proceedings of the 2016 Summer Biomechanics Bioengineering and Biotransport Conference,scientific sessions 218 2016 [Refereed]
Investigation of flow instability with vascular geometry at the bifurcation of middle cerebral arteries from healthy volunteers

Murayoshi T, Yagi T, Tobe Y, Umezu M

Proceedings of the 2016 Summer Biomechanics Bioengineering and Biotransport Conference 215 2016 [Refereed]
Pathological engineering study of human cerebral aneurysms three dimensional accumulation of foam cells versus hemodynamics

Suto K, Yagi T, Tobe Y, Kawamura K, Umezu M

Proceedings of the 2016 summer biomechanics bioengineering and biotransport conference 197 2016 [Refereed]
2A33 Study on an adaptation of hemodynamics before and after cerebrovascular bypass surgery

TAKAMURA Kenji, UMEZU Mitsuo, YAGI Takanobu, WATANABE Mikihiko, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, Iida Hidehiro, NUMATA Naoki, NAKAMURA Masanori

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2015 ( 0 ) 325 - 326 2015 [Refereed]

DOI CiNii
2A33 Study on an adaptation of hemodynamics before and after cerebrovascular bypass surgery

TAKAMURA Kenji, UMEZU Mitsuo, YAGI Takanobu, WATANABE Mikihiko, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, Iida Hidehiro, NUMATA Naoki, NAKAMURA Masanori

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2015 ( 0 ) 325 - 326 2015 [Refereed]

DOI CiNii
Induced Pluripotent Stem Cell Differentiation under Constant Shear Stress

N. K. Mohd Zin, K. Sakaguchi, Y. Haraguchi, T. Yagi, K. Masuura, T. Shimizu, M. Umezu

7TH WACBE WORLD CONGRESS ON BIOENGINEERING 2015 52 7 - 10 2015 [Refereed]

　View Summary

Mechanotransduction in in-vitro studies has yet to be done extensively using human induced pluripotent (hiPS) cells. These external mechanical factors are important controlling factor for cell differentiation at a cellular level particularly in cardiomyocytes cells. Cells in a living body are being exposed to many kind of stresses; shear stress in particular modulates cellular function in a living body. Similarly, we are trying to understand the link between the shear stress in the bioreactor and the differentiation effects it has on iPS cells. In this study, we investigate the difference of strictly uniform laminar shear stress with a non-uniform laminar flow and its effects on the cell survival rate and differentiation. Additionally, the elimination of biochemical factors were done to satisfy the need of demand for clinically usable cells for the near future use. By eliminating cytokine induced differentiation. In addition, information pertaining to relationship between fluid shear stress, cellular deformations, cell differentiation and cell survival rate could provide a more optimised condition for cultivation specific type of cells within a shorter time period.

DOI

Scopus
Optimal kissing balloon inflation after single-stent deployment in a coronary bifurcation model

Yoshinobu Murasato, Kiyotaka Iwasaki, Tadashi Yamamoto, Takanobu Yagi, Yutaka Hikichi, Yasunori Suematsu, Tomohiko Yamamoto

EUROINTERVENTION 10 ( 8 ) 934 - 941 2014.12 [Refereed]

　View Summary

Aims: To define the optimal kissing balloon inflation (KBI) after single-stent deployment in a coronary bifurcation model.
Methods and results: We deployed stents in main vessels (MV) followed by KBI in various conditions and compared the stent configurations. A) KBI at the operator's discretion vs. under the guidelines of minimal balloon overlapping (MBO). Various stent configurations were observed after the former option, whereas similar maximal dilation points were observed under the MBO guidelines. B) Long balloon overlapping (LBO) vs. MBO with proximal MV dilated by a large balloon. The proximal MV was dilated to an ideal round shape with MBO versus an oval shape with LBO. C) Two-link vs. 3-link stents. Although the 2-link stent was advantageous to open the side branch, it incurred a risk of overdilatation of the proximal struts, whereas the 3-link stent preserved its structure. Computed simulations of coronary flow were analysed in the following left main coronary models: circle with a diameter of 4 and 5 5 mm, ellipse with longitudinal direction and tilt position. They revealed that the overdilated side was exposed to low shear stress regardless of its shape.
Conclusions: Optimal KBI can be achieved with MBO and proximal dilatation by an optimally sized balloon.

DOI PubMed
1G13 Study of hemodynamics in cerebrovascular bypass surgery

TAKAMURA Kenji, UMEZU Mitsuo, YAGI Takanobu, YAMANASHI Momoko, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, Iida Hidehiro, SATO Kota, NAKAMURA Masanori

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2014 ( 0 ) 211 - 212 2014 [Refereed]

DOI CiNii
1G13 Study of hemodynamics in cerebrovascular bypass surgery

TAKAMURA Kenji, UMEZU Mitsuo, YAGI Takanobu, YAMANASHI Momoko, KATAOKA Hiroharu, YAMAMOTO Akihide, IGUCHI Satoshi, Iida Hidehiro, SATO Kota, NAKAMURA Masanori

The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2014 ( 0 ) 211 - 212 2014 [Refereed]

DOI CiNii
Relationship between pathology and hemodynamics of human unruptured cerebral aneurysms

Yasutaka Tobe, Takanobu Yagi, Yuki Iwabuchi, Momoko Yamanashi, Kenji Takamura, Takuma Sugiura, Mitsuo Umezu, Yoshifumi Hayashi, Hirotaka Yoshida, Atsushi Nakajima, Kazutoshi Nishitani, Yoshifumi Okada, Michihito Sugawara, Shin Hiraguchi, Toshiro Kubo, Shigemi Kitahara

IFMBE Proceedings 43 44 - 47 2014 [Refereed]

　View Summary

This research compared the intraoperative appearance, computational fluid dynamic (CFD) analysis, and scanning electron microscope (SEM) observation of endothelial cells (EC) of seven human cerebral aneurysms in an effort to find the relationship between hemodynamic patterns and wallthinning of aneurysms. Aneurysm walls were categorized into blister-like appearance as thinning, similar appearance to the parental artery or white thickened part as thickening, and areas similar to arteriosclerosis as calcifying region. Seven aneurysms were dissected after clipping operation with markings to confirm the orientation of specimens. Specimens were rinsed in PBS, immersed into 2% glutaraldehyde, 1% osmium solution, graded series of ethanol and tertiary-butyl alcohol, and freeze-dried to observe under SEM. For CFD analysis, 3 dimensional vascular models were constructed and meshed using tetra and prism mesh. The inlet boundary condition used an average flow rate of 350 ml/min. The outlet boundary conditions were set to flow rates based on literature data and for regions with unknown flow rates were set to static pressure. Vascular models were analyzed using CFX 13.0 (ANSYS). Aneurysms contained four thinning, six thickening, and four calcifying regions. SEM analysis showed variations of endothelial cell patterns over aneurysms. Missing EC was only found at thinning regions and all thickening and calcifying regions confirmed damaged or normal EC. CFD analysis showed impinging flow at the thinning region. Impingement was defined by the direction of wall shear stress (WSS) vector and rise of pressure at wall. The impinging flow was only found at the thinning region. The WSS magnitude did not confirm any relationship between wall characteristics or EC patterns. These results suggested that the impinging flow may cause wall thinning of aneurysm.

DOI

Scopus

4

Citation

(Scopus)
COMBINED ANALYSIS OF PATHOLOGY AND HEMODYNAMICS OF HUMAN UNRUPTURED CEREBRAL ANEURYSM WITH THIN-WALLED REGION

Yasutaka Tobe, Takanobu Yagi, Yuki Iwabuchi, Momoko Yamanashi, Kenji Takamura, Kiyotaka Iwasaki, Mitsuo Umezu, Yoshifumi Hayashi, Hirotaka Yoshida, Atsushi Nakajima, Kazutoshi Nishitani, Yoshifumi Okada, Michihito Sugawara, Shin Hiraguchi, Toshiro Kubo, Shigemi Kitahara

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2013, PT A 2014 [Refereed]

DOI

Scopus

1

Citation

(Scopus)
Visual analytics of malignant blood flow for medical professionals

Takanobu Yagi, Takeharu Hoshi, Young Park

2014 IEEE Pacific Visualization Symposium (PacificVis) 342 - 343 2014 [Refereed]

　View Summary

Arterial diseases of sclerosis and aneurysm are known to be related with a local blood flow. There are indeed decades of related studies, recently being with an aid of a computational approach on a patient-specific basis, but those have yet to be translated into clinical medicine. "Simply why?", and "how to achieve it?" Computational blood flow originates from theoretical and computational fluid dynamics. Understanding the underlying knowledge may be beyond the scope of medical professionals. Engineers have to be fully aware of a barrier on an interface with clinical medicine, and manage to translate the evolving technology with a special focus on balancing the efficacy and safety. Visual analytics is to facilitate to overcome an academic gap between engineering and clinical medicine. This paper deals with the recent development of visual analytics of malignant blood flows in cerebral aneurysms for medical professionals.

DOI

Scopus

1

Citation

(Scopus)
Novel connecting tube for saline chaser in contrast-enhanced CT: The effect of spiral flow of saline on contrast enhancement

Masafumi Kidoh, Takeshi Nakaura, Kazuo Awai, Koji Yuba, Takayuki Kobayashi, Young-Kwang Park, Takanobu Yagi, Kazunori Harada, Yasuyuki Yamashita

European Radiology 23 ( 11 ) 3213 - 3218 2013.11 [Refereed]

　View Summary

Objective: To evaluate the effect of a newly developed connecting tube, which generates a spiral flow of saline, on aortic and hepatic contrast enhancement during hepatic-arterial phase (HAP) and portal venous phase (PVP) computed tomography (CT). Methods: Eighty patients were randomly assigned to one of two protocols: with a new or a conventional tube. The contrast material (600 mgI/kg) was delivered over 30 s
this was followed by the administration of 25 ml saline solution delivered at the same injection rate as the contrast material. Unenhanced and contrast-enhanced CT images of the upper abdomen were obtained. We calculated the changes in the CT number (â̂†HU) for the aorta during HAP and PVP, and for the liver during PVP. We compared â̂†HU between protocols. Results: The mean â̂†HU for the abdominal aorta during HAP was significantly higher with the new tube protocol than with the conventional tube protocol (322 ± 53 vs. 290 ± 53, P &lt
0.01). There were no significant differences in the mean â̂†HU for the abdominal aorta and liver during PVP between the two protocols (P &gt
0.05). Conclusion: The new connecting tube increased the effect of a saline chaser and significantly improved aortic enhancement during HAP. © 2013 European Society of Radiology.

DOI PubMed

Scopus

10

Citation

(Scopus)
Numerical analysis of blood flow distribution in 4-and 3-branch vascular grafts

Chikako Konoura, Takanobu Yagi, Masanori Nakamura, Kiyotaka Iwasaki, Yi Qian, Shigeo Okuda, Akihiro Yoshitake, Hideyuki Shimizu, Ryohei Yozu, Mitsuo Umezu

JOURNAL OF ARTIFICIAL ORGANS 16 ( 2 ) 157 - 163 2013.06 [Refereed]

　View Summary

Trifurcated arch grafts (3-branch grafts) are now being used to repair the thoracic aorta in addition to conventional arch grafts (4-branch grafts). The anatomical shape of the 3-branch graft is different from the original vessel, so it is necessary for clinical application to evaluate blood flow distribution in the graft to assess whether there is adequate blood flow to the target organs. To achieve this, we developed a computational fluid dynamics (CFD) method to evaluate blood flow distribution in the grafts. Aortic blood flow was measured by phase-contrast magnetic resonance imaging (PC-MRI), and flow distribution into the branched vessels was obtained. The MRI image was used to create a patient-specific image model that represents the geometry of the aortic arch. The CFD analysis method was employed to determine a boundary condition of the blood flow analysis in the aorta using a patient-specific image model. We also created simplified models of 4-branch and 3-branch grafts and used our CFD analysis method to compare blood flow distribution among simplified models. It was found that blood flow distribution in the descending aorta was 71.3 % for the 4-branch graft and 67.7 % for the 3-branch graft, indicating that a sum of branching flow in the 3-branch graft was almost the same as the one in the 4-branch graft. Therefore, there is no major concern about implanting a new 3-branch graft. Our CFD analysis method may be applied to estimate blood flow distribution of a newly developed vascular graft prior to its clinical use and provide useful information for safe use of the graft.

DOI PubMed

Scopus

6

Citation

(Scopus)
Experimental insights into flow impingement in cerebral aneurysm by stereoscopic particle image velocimetry: transition from a laminar regime

Takanobu Yagi, Ayaka Sato, Manabu Shinke, Sara Takahashi, Yasutaka Tobe, Hiroyuki Takao, Yuichi Murayama, Mitsuo Umezu

JOURNAL OF THE ROYAL SOCIETY INTERFACE 10 ( 82 ) 20121031 2013.05 [Refereed]

　View Summary

This study experimentally investigated the instability of flow impingement in a cerebral aneurysm, which was speculated to promote the degradation of aneurysmal wall. A patient-specific, full-scale and elastic-wall replica of cerebral artery was fabricated from transparent silicone rubber. The geometry of the aneurysm corresponded to that found at 9 days before rupture. The flow in a replica was analysed by quantitative flow visualization (stereoscopic particle image velocimetry) in a three-dimensional, high-resolution and time-resolved manner. The mid-systolic and late-diastolic flows with a Reynolds number of 450 and 230 were compared. The temporal and spatial variations of near-wall velocity at flow impingement delineated its inherent instability at a low Reynolds number. Wall shear stress (WSS) at that site exhibited a combination of temporal fluctuation and spatial divergence. The frequency range of fluctuation was found to exceed significantly that of the heart rate. The high-frequency-fluctuating WSS appeared only during mid-systole and disappeared during late diastole. These results suggested that the flow impingement induced a transition from a laminar regime. This study demonstrated that the hydrodynamic instability of shear layer could not be neglected even at a low Reynolds number. No assumption was found to justify treating the aneurysmal haemodynamics as a fully viscous laminar flow.

DOI PubMed

Scopus

56

Citation

(Scopus)
Prediction of Wall-thinning Area in Unruptured Intracerebral Aneurysms by Computational Fluid Dynamics

Yoshifumi Hayashi, Takanobu Yagi, Yasutaka Tobe, Yuki Iwabuchi, Momoko Yamanashi, Kenji Takamura, Kiyotaka Iwasaki, Mitsuo Umezu, Takashi Ishida, Atsushi Nakajima, Hirotaka Yoshida, Kazutoshi Nishitani, Yoshihisa Ota, Michihito Sugawara, Yoshifumi Okada, Toshiro Kubo, Shigemi Kitahara

STROKE 44 ( 2 ) 2013.02 [Refereed]
Relationship between pathology and hemodynamics of human unruptured cerebral aneurysms

Tobe Y, Yagi T, Kawamura K, Umezu M

Proceedings of the ICBME 2013 55 - 56 2013 [Refereed]
Investigation of collision dynamics and destruction of human erythrocytes with varying elongation using high-speeg microfluidics

Umetani K, Yagi T, Umezu M

Proceedings of the FULUCOME 2013 2013 [Refereed]
Comparison of endothelial cells and hemodynamic flow patterns of three human unruptured cerebral aneurysms

Tobe Y, Yagi T, Kawamura K, Umezu M

Proceedings of the FULUCOME 2013 2013 [Refereed]
INVESTIGATION ON A RELATIONSHIP BETWEEN HEMODYNAMICS AND WALL-THINNING IN AN UNRUPTURED HUMAN CEREBRAL ANEURYSM

Yasutaka Tobe, Takanobu Yagi, Sara Takahashi, Yuki Iwabuchi, Momoko Yamanashi, Kiyotaka Iwasaki, Mitsuo Umezu, Yoshifumi Hayashi, Hirotaka Yoshida, Kazutoshi Nishitani, Yoshifumi Okada, Michihito Sugawara, Shin Hiraguchi, Toshiro Kubo, Shigemi Kitahara

PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B 853 - 854 2012 [Refereed]

DOI

Scopus
Effect of bileaflet valve orientation on the 3d flow dynamics in the sinus of valsalva

Takanobu Yagi, William Yang, Mitsuo Umezu

Journal of Biomechanical Science and Engineering 6 ( 2 ) 64 - 78 2011 [Refereed]

　View Summary

Three-dimensional (3D) evolutional behavior of flow dynamics in the aortic sinus of Valsalva was studied in vitro for finding the effects of bileaflet valve orientations in an effort to investigate possible linkages between the sinus flow and coronary circulation. A realistic model of the aortic sinus was machined inside an acrylic block. A St. Jude Medical bileaflet aortic valve was utilized. Two orientations were compared
(1) a pair of hinges aligned in the direction of the non-coronary sinus of the model (N0) and (2) of the left and right sinuses (N90). A 3D scanning three-component velocity measurement, named Fluorescent Scanning Stereoscopic Particle Image Velocimetry (FS-SPIV), was developed. Measured data were validated with an aid of two-dimensional particle image velocimetry. Good agreement confirmed the capability of quantifying the 3D mean and turbulent behavior of sinus vortices. The valve orientation was found to be unable to affect the sinus vortices during peak-systole, but had a substantial impact on regurgitation during end-systole. The superior case (N0) gave a symmetric regurgitation. The regurgitant jet was directed to the non-coronary sinus. The left and right sinuses were dominated by a well-organized recirculation from a persistent forward flow. The inferior case (N90) produced an asymmetric regurgitation with a biased jet into the left or right sinuses, leading to produce unexpected turbulence near the entrance of coronary artery. Those results suggest possible linkages between the sinus flow and coronary circulation, thereby advocating the existence of an optimal orientation of bileaflet valves. © 2011 by JSME.

DOI

Scopus

15

Citation

(Scopus)
単一細胞高速イメージングによるヒト赤血球衝突破壊動態の検討

木田大輔, 八木高伸, 梅津光生

可視化情報学会誌 31 ( 1 ) 391 - 394 2011
ヒト脳動脈瘤の組織変性プロセスに関与する異常血流の特定に向けて：ブレブ発生・成長と衝突流れの相関

八木高伸, 林祥史, 梅津光生

日本機械学会2011年度年次大会講演論文集 2011
Experimental insight into modeling of cerebral aneurysm hemodynamics: comparison between Stereo PIV and CFD

Takahashi S, Yagi T, Umezu M

Proceedings of 11th Asian Symposium on Visualization 2011 [Refereed]
Experimental insight into spatial and temporal dynamics of wall shear rate using elastic replicas of human cerebral aneurysms with fluorescent Stereo PIV

Yagi T, Shinke M, Umezu M

Proceedings of 11th Asian Symposium on Visualization 2011 [Refereed]
"Wind tunnel" in vascular hemodynamics: why and how?

Yagi T, Takahashi S, Tobe Y, Umezu M, Takao H, Murayama Y

Proceedings of the FULUCOME 2011 2011 [Refereed]
Wall shear stress measurement on an elastic boundary in hemodynamic modeling of cerebral aneurysm using fluorescent scanning Stereo PIV

Yagi T, Takahashi S, Umezu M

Proceedings of 9th International Symposium on Particle Image Velocimetry 2011 [Refereed]
Two Stenting at Coronary Artery Bifurcation Yields Slow-Flow Region at Carina: In vitro Pulsatile Flow Investigation Using Elastic 3-Dimensional Stenotic Bifurcated Artery Replica

Kiyotaka Iwasaki, Takanobu Yagi, Tadashi Yamamoto, Yuichi Yagishita, Manabu Shinke, Yusuke Noguchi, Sara Takahashi, Mitsuo Umezu

CIRCULATION 122 ( 21 ) 2010.11 [Refereed]
Single-cell real-time imaging of flow-induced hemolysis using high-speed microfluidic technology

T. Yagi, S. Wakasa, N. Tokunaga, Y. Akimoto, M. Umezu

WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, VOL 25, PT 4: IMAGE PROCESSING, BIOSIGNAL PROCESSING, MODELLING AND SIMULATION, BIOMECHANICS 25 ( 4 ) 2337 - 2340 2010 [Refereed]

　View Summary

Understanding the mechanism of flow-induced blood cell damage, such as hemolysis and platelet activation, plays an important role for arterial diseases and artificial organs. This study for the first time demonstrates the visualization of flow-induced hemolysis in a single-cell real-time manner using high-speed microfluidic technology. Impinging microjets with a velocity of 1.5 m/s order at a nozzle exit were made in the Y- and T-shaped microchannel. The curved (r=10 mu m) and flat collision surface were compared. Porcine fresh erythrocytes were suspended in PBS at Ht=0.5%. Results showed that membrane failure was only observed in the Y-junction. These erythrocytes were initially elongated at the far region, and then longitudinally compressed in the near wall region due to the sharp adverse pressure gradient, whereas those in the T-junction released the membrane tension as the pressure difference per erythrocyte diminished. In the simulation of energy balance, it was found that the dominant force for the longitudinal compression was the pressure difference per erythrocyte. Such erythrocytes showed the sudden drop of elastic modulus, suggesting that the elongated spectrin network of erythrocyte was fragile for the compressive force and immediately broken by the impact force.

DOI
High-speed microfluidic study of colliding human erythrocytes at a single-cell real-time scale

Yagi T, Akimoto Y, Umezu M

Proceedings of 6th World Congress on Biomechanics 2010 [Refereed]
3D near-wall flow mapping by fluorescent Stereo-PIV in an elastic replica of human cerebral aneurysm

Yagi T, Sato A, Umezu M

Proceedings of International Symposium on Flow Visualization 2010 2010 [Refereed]
Biomedical Engineering Analysis of the Rupture Risk of Cerebral Aneurysms: Flow Comparison of Three Small Pre-ruptured Versus Six Large Unruptured Cases

A. Kamoda, T. Yagi, A. Sato, Y. Qian, K. Iwasaki, M. Umezu, T. Akutsu, H. Takao, Y. Murayama

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3 23 ( 1-3 ) 1600 - + 2009 [Refereed]

　View Summary

A relationship between blood flows in cerebral aneurysms and their rupture remains obscure. In clinical practice, the size of aneurysms is one of the important factors for determining a strategy of treatment, but in our database three small aneurysms became ruptured during follow-up. Here, we aim to study their pre-ruptured hemodynamics, and differentiate them with those of six large unruptured aneurysms. All the aneurysms occurred in internal carotid artery, and their mean sizes were 6 and 10.8 mm for pre-ruptured and unruptured cases, respectively. We reproduced their replica as a patient-specific elastic model using clinical images obtained by digital subtraction angiography and a series of rapid proto-typing techniques. Flows were reproduced in vitro using a cerebral flow simulator, and visualized by Time-resolved Particle Image Velocimetry. All pre-ruptured cases showed the collision of an incoming flow at a distal neck, and formed a prominent jet stream directing towards the aneurismal head. In contrast, none of unruptured aneurysms had such a marked impingement, and their flows were most likely characterized by swirling patterns. All unruptured cases occurred in a twisted vessel, or carotid siphon, whereas pre-ruptured ones were located downstream whose geometries consisted of a simple curvature. These findings suggest that internal carotid artery has a regional dependency of the risk of aneurismal rupture. Furthermore, the presence of jet streams for small-sized aneurysms may be a substantial indicator of the rupture and immediate treatments.

DOI

Scopus

2

Citation

(Scopus)
Microscale Visualization of Erythrocyte Deformation by Colliding with a Rigid Surface Using a High-Speed Impinging Jet

S. Wakasa, T. Yagi, Y. Akimoto, N. Tokunaga, K. Iwasaki, M. Umezu

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3 23 ( 1-3 ) 1422 - + 2009 [Refereed]

　View Summary

Erythrocyte deformation by colliding with a rigid surface using a high-speed impinging jet was studied with microfluidic techniques. We aim to investigate the relevance of colliding erythrocytes with hemolysis. A micro-channel chip was made of polydimenthyl-siloxane (PDMS), which comprised a T- and V-shaped junction with a micro-nozzle and diffuser in order to attain a high-speed microflow with a jet velocity of m/s scale. A high-speed camera with a microscope imaged colliding erythrocytes by shadow imaging. Porcine erythrocyte with a hematocrit of 0.5% in phosphate buffer saline was utilized. At the Y-junction, erythrocytes showed buckling due to an impulsive, longitudinal, compressive deformation. Such anomalous phenomena were not detected at the T-junction, where erythrocytes underwent sequential compressions as approaching the colliding surface. Erythrocyte after buckling showed a hazy membrane while being released from the colliding surface, suggesting the ejection of hemoglobin out of the pore on a membrane. Flow-induced hemolysis has been considered as a model of viscous shear stress and exposure time. From our data, however, it was suggested that hemolysis due to a high-speed impinging flow characterized by mechanical heart valve flows may arise as an impulsive failure of erythrocyte membrane upon collision.

DOI

Scopus

2

Citation

(Scopus)
New challenge for studying flow-induced blood damage: macroscale modeling and microscale verification

T. Yagi, S. Wakasa, N. Tokunaga, Y. Akimoto, T. Akutsu, K. Iwasaki, M. Umezu

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3 23 ( 1-3 ) 1430 - + 2009 [Refereed]

　View Summary

Prosthetic heart valves often induce blood cell trauma, but its mechanism is not clearly understood due to the complexity of dynamical flows. We herein propose a new challenge, termed macroscale modeling and microscale verification. This report is the former, and here we aim to clarify the physical interpretation of Reynolds stress for flowing cells. One polymer and two mechanical valves are compared, and the Reynolds stress is visualized using a novel analytical technique including time-resolved particle image velocimetry and continuous wavelet transform. The method enables to analyze the dynamics of Reynolds stress in a spatial and temporal domain. As a result, it is found that the Reynolds stress should be considered as an indicator of impinging flows for circulating cells. Such flows may impulsively apply a colliding force on a membrane of flowing cells. As microscale verification based on this new hypothesis, we are currently investigating such collision phenomena of flowing cells using high-speed microfluidic techniques.

DOI

Scopus

1

Citation

(Scopus)
Collision dynamics of red blood cells using high-speed impinging microjets

Yagi T, S. Wakasa, N. Tokunaga, Y. Akimoto, M. Umezu

Proceedings of 10th international conference on fluid control, measurements, and visualization 2009 [Refereed]
3D volume visualization for vascular flow modeling using stereo PIV with fluorescent tracer particles

Yagi T, Kamoda A, Yang W, Umezu M

Proceedings of the 8th international symposium on particle image velocimetry 2009 [Refereed]
In vitro study of the 3D vortical flow structure in the sinus of Valsalva using multiplane scanning stereo PIV: implication for coronary circulation

Yagi T, Yang W, Wakasa S, Umezu M

Proceedings of the 13th International Symposium on Flow Visualization 2008 [Refereed]
走査型ステレオPIV法を用いた異なる大動脈バルサルバ洞形状をもつ Valved Graft 内の3次元流動特性

八木高伸, 若狭翔太郎, William Yang, 岩清隆, 梅津光生

日本機械学会創立110周年記念2007年度年次大会講演論文集 5 295 - 296 2007.09
Coil compaction予測のための時系列PIV法を用いた実形状弾性脳動脈瘤モデル内の流れの可視化

松本徹, 岩清隆, 八木高伸, 福島桃子, 鴨田明憲, 梅津光生, 阿久津敏乃介, 高尾洋之, 石橋敏寛, 村山雄一

第19回バイオエンジニアリング講演会講演論文集 82 - 83 2007.01
ステレオPIV法を用いた大動脈バルサルバ洞内の3次元流れ場構造に関する基礎知識

須藤宏幸, 八木高伸, 石川大輔, 若狭翔太朗, William Yang, 岩清隆, 梅津光生

第19回バイオエンジニアリング講演会講演論文集 62 - 63 2007.01
リアルタイム周波数解析を用いた人工弁閉鎖時に発達する瞬時高周波ストレスの検討

石川大輔, 八木高伸, 須藤宏幸, 若狭翔太朗, 阿久津敏乃介, 岩清隆, 梅津光生

第19回バイオエンジニアリング講演会講演論文集 60 - 61 2007.01
Numerical and experimental study on the vortex flow structure inside a spiral vortex ventricular assist device

Cheung S, Tu JY, Yagi T, Yang W, Umezu M

Journal of Biomechanics 40 ( S2 ) S478 2007 [Refereed]
Three-dimensional fluid mechanics of the sinus of Valsalva with a bileaflet mechanical heart valve

Takanobu Yagi, Daisuke Ishikawa, Hiroyuki Sudo, Shotaro Wakasa, William Yang, Kiyotaka Iwasaki, Mitsuo Umezu

PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007 187 - 188 2007 [Refereed]
Real-time planar spectral analysis of instantaneous high-frequency stress on blood cells downstream of an artificial heart valve

Yagi T, W. Yang, M. Umezu

Proceedings of the 12th International Symposium on Flow Visualization 2006 [Refereed]
Multiplane scanning Stereo-PIV measurements of flow inside a spiral vortex pulsatile blood pump

Yagi T, Yang W, Ishikawa D, Sudo H, Iwasaki K, Umezu M

Proceedings of the 13th International Symposium on Applications of Laser Techniques to Fluid Mechanics 2006 [Refereed]
3D quantitative flow visualization of a spiral vortex pulsatile blood pump using Stereoscopic PIV

Yang W, Yagi T, Ishikawa D, Sudo H, Iwasaki K, Umezu M, Tu JY

Proceedings of the 12th International Symposium on Flow Visualization 2006 [Refereed]
Stereoscopic Particle Image Velocimetry for application in Three-dimensional flow within a Spiral Vortex Pulastile Blood Pump

Yagi T, Yang W, Ishikawa D, Iwasaki K, Umezu M

Biocybernetics and Biomedical Engineering 26 ( 1 ) 39 - 48 2006 [Refereed]
Stereoscopic particle image velocimetry measurements toward three dimensional flow investigations within the spiral vortex blood pump "jointly worked"

Yagi T, Yang W, Ishikawa D, Iwasaki K, Umezu M

Lecture Notes of the ICB Seminar 8th Polish-Japanese Seminar on New Technologies For Future Artificial Organs 106 - 112 2005.08
脳動脈瘤治療法の評価を目的とした拍動循環シミュレータの開発

栗山仁志, 岩崎清隆, 八木高伸, 高島俊洋, 藤井麻由, 石川大輔, 梅津光生, 阿久津敏乃介, 高尾洋之, 石橋敏寛, 村山雄一

第17回バイオエンジニアリング講演会講演論文集 397 - 398 2005.01
Stereoscopic PIV measurements on 3D swirling convergent flows inside a Spiral Vortex ventricular assist device

Yagi T, Yang W, Umezu M

Proceedings PIV’05, 6th International Symposium on Particle Image Velocimetry 2005 [Refereed]
An investigation of instantaneous high-frequency turbulent stress in the vicinity of artificial heart valves using wavelet transform analysis of Dynamic PIV measurements

Yagi T, Ishikawa D, Sudo H, Akutsu T, Yang W, Iwasaki K, Umezu M

Proceedings of the IFMBE, The 12th ICBME 12 2005 [Refereed]
An experimental investigation of three-dimensional pulsatile flow structures within the Spiral Vortex Ventricular Assist Device using Stereoscopic PIV

Yagi T, Yang W, Ishikawa D, Sudo H, Iwasaki K, Umezu M

Proceedings of the IFMBE, The 12th ICBME 12 2005 [Refereed]
人工心臓26題

梅津光生, 見藤歩, 八木高伸, 岩崎清隆, 小堀賢司, 今井浩二, 福長一義

人工臓器 33 ( 2 ) s146 - s148 2004

DOI CiNii
Silicone vascular models for analysis of carotid artery stenting

Okamoto Y, Inukai H, Kobashi H, Yamaga H, Yagi T, Iwasaki K, Shiurba R, Umezu M

IFMBE Proceedings 31 398 - 401

DOI

Scopus
Modeling of fluid flow in a pulsatile artificial blood pump: implication for thrombosis

YAGI Takanobu

[Refereed]
人工心臓の血液適合性評価に向けた新可視化技術の基礎検討

八木高伸

早稲田大学 [Refereed]

▼display all

Books and Other Publications

基礎からよくわかる実践的CFD（数値流体力学）入門

八木高伸( Part： Contributor, 7.3 CFDの論文の書き方ポイント、7.4 数値流体力学を原理から現場へ)

メディカ出版 2017
次世代診断治療支援のための血流シミュレーション

八木高伸( Part： Joint author, 第3章血流シミュレーションの方法、第5章血流シミュレーションの結果と解釈、第6章血流シミュレーションの事例)

日本機械学会 2016
医療現場のための数値流体力学（全7回）

八木高伸( Part： Sole author)

日本診療放射線技師会誌 2014

Presentations

数値流体力学（CFD）による冠動脈血流シミュレーション

八木高伸 [Invited]

FRIENDS

Presentation date： 2017
数値流体力学（CFD）による心臓，脳血管障害の診断治療支援：現状と展望

八木高伸 [Invited]

日本放射線技術学会近畿支部平成29年度秋季勉強会

Presentation date： 2017
医工連携による脳動脈瘤の病態解明―次世代診断治療支援技術を目指して―

八木高伸 [Invited]

第19回中国四国脳卒中研究会

Presentation date： 2017
Computational Fluid Dynamics for Assisting Neurosurgery: Basic Principles

八木高伸 [Invited]

第13回国際脳卒中外科学会

Presentation date： 2017
数値流体力学による脳動脈瘤の血流解析：15年のレビュー

八木高伸 [Invited]

第33回NPO法人日本脳神経血管内治療学会学術総会

Presentation date： 2017
数値流体力学による血管障害の診断治療支援：現状と展望

八木高伸 [Invited]

第16回CTテクノロジーフォーラム

Presentation date： 2017
マイクロ流路を用いた血流停滞と赤血球凝集に関する研究

鈴木砂良, 八木高伸, 横山孝太, 梅津光生

第29回バイオエンジニアリング講演会

Presentation date： 2017
直線マイクロ流路を用いた高せん断流れ場における血栓形成因子の活性化に関する研究

横山孝太, 八木高伸, 鈴木砂良, 梅津光生

第29回バイオエンジニアリング講演会

Presentation date： 2017
脳動脈瘤発症メカニズム解明に向けた瘤患者と健常者における血管形態の特徴に関する検討

村吉大阿, 八木高伸, 戸部泰貴, 梅津光生

第29回バイオエンジニアリング講演会

Presentation date： 2017
脳動脈瘤菲薄メカニズム解明に向けた平滑筋細胞と血行動態の病理工学的検討

戸部泰貴, 八木高伸, 須藤健太, 王心寧, 川村公一, 梅津光生, 吉田浩貴, 林祥史, 西谷和敏, 岡田義文

第29回バイオエンジニアリング講演会

Presentation date： 2017
脳動脈瘤破裂メカニズム解明に向けた未破裂・破裂瘤における壁厚と壁細胞の病理工学的検討

須藤健太, 八木高伸, 戸部泰貴, 川村公一, 梅津光生, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂美

第29回バイオエンジニアリング講演会

Presentation date： 2017
脳動脈瘤の発祥解明に向けた瘤発症分岐部と未発症分岐部の病理特徴の検討

王心寧, 八木高伸, 戸部泰貴, 須藤健太, 吉田浩貴, 林祥史, 西谷和敏, 岡田義文, 北原茂美, 川村公一, 梅津光生

第29回バイオエンジニアリング講演会

Presentation date： 2017
脳虚血患者における脳主幹動脈供給血流量と脳組織需要血流量の関係性の検討

西条卓人, 八木高伸, 高西清文, 戸部泰貴, 片岡大治, 山本明秀, 井口智史, 飯田秀博, 菅原裕太, 中村匡徳, 梅津光生

第29回バイオエンジニアリング講演会

Presentation date： 2017
脳血管バイパス術患者における壁面せん断応力一定性の検討

高西清文, 八木高伸, 西条卓人, 戸部泰貴, 山本明秀, 井口智史, 飯田秀博, 中村匡徳, 菅原裕太, 梅津光生

第29回バイオエンジニアリング講演会

Presentation date： 2017
ヒト脳動脈瘤の発症メカニズム解明に向けた脳血管分岐部内腔における三次元内膜肥厚分布解析

王心寧, 須藤健太, 臼井一晃, 亀岡洋一郎, 八木高伸, 川村公一, 梅津光生

第30回バイオエンジニアリング講演会

Presentation date： 2017
マイクロ流路を用いた血流の衝突と血小板凝集の関係性に関する研究

横山孝太, 八木高伸, 篠崎駿, 梅津光生

第30回バイオエンジニアリング講演会

Presentation date： 2017
ヒト脳動脈瘤破裂因子の特定に向けた病理工学的検討：壁の菲薄化と炎症細胞の関連性

須藤健太, 八木高伸, 王心寧, 川村公一, 梅津光生, 吉田浩貴, 西谷和俊, 岡田義文, 北原茂実

第28回バイオフロンティア講演会

Presentation date： 2017
数値流体力学（CFD）による冠動脈血流シミュレーション

八木高伸 [Invited]

FRIENDS

Presentation date： 2016
医工連携による脳動脈瘤病態解明の新展開

八木高伸 [Invited]

東海クモ膜下出血研究会

Presentation date： 2016
Computational fluid dynamicsの冠循環への応用

八木高伸 [Invited]

POPAI

Presentation date： 2016
循環器系疾患のための次世代診断治療支援技術：血流解析シミュレーション

八木高伸 [Invited]

第20回CTサミット

Presentation date： 2016
医工学による未来医療：血流を診る

八木高伸 [Invited]

高知大学大学院博士課程医学専攻DCセミナー

Presentation date： 2016
医工連携による医療機器開発:工学から医学への期待

八木高伸 [Invited]

第80回日本循環器学会学術集会日本機械学会ジョイントシンポジウム

Presentation date： 2016
Stereo PIVを用いた大動脈弁モデル近傍の流れ場の可視化手法の開発

高橋東, 須藤健太, 戸部康貴, 松橋祐輝, 鈴木砂良, 八木高伸, 佐々木崇史, 滝沢研二

第28回バイオエンジニアリング講演会

Presentation date： 2016
健常者の脳血管形状を用いた脳動脈瘤好発部位における血流の特徴に関する検討

村吉大阿, 八木高伸, 戸部泰貴, 杉浦拓磨, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

第28回バイオエンジニアリング講演会

Presentation date： 2016
血管吻合形状のモデル化とエネルギー損失値との関係性に関する検討

尾山大輔, 朴栄光, 八木高伸, 岩崎清隆, 小坂眞一, 梅津光生

第28回バイオエンジニアリング講演会

Presentation date： 2016
マイクロ流路を用いた血流の衝突と血栓形成因子の活性化に関する研究

手塚諒, 八木高伸, 衛冉, 梅津光生

第28回バイオエンジニアリング講演会

Presentation date： 2016
健常者脳主幹動脈における壁面せん断応力一定性の検討

高西清文, 八木高伸, 渡邊幹彦, 梅津光生, 中村匡徳, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

第28回バイオエンジニアリング講演会

Presentation date： 2016
脳血行再建術前後における需要血流量と供給血流量の関係性

渡邊幹彦, 八木高伸, 高西清文, 片岡大治, 山本明秀, 井口智史, 飯田秀博, 中村匡徳, 梅津光生

第28回バイオエンジニアリング講演会

Presentation date： 2016
ヒト未破裂脳動脈瘤の病理的工学研究：壁性状に応じた泡沫細胞分布に関する検討

須藤健太, 八木高伸, 杉浦拓磨, 戸部泰貴, 川村公一, 梅津光生, 林祥史, 吉田浩貴, 岡田義文, 北原茂実

第28回バイオエンジニアリング講演会

Presentation date： 2016
ヒト未破裂脳動脈瘤の病理工学的研究：壁細胞密度による組織再生能に関する検討

杉浦拓磨, 八木高伸, 戸部泰貴, 須藤健太, 川村公一, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

第28回バイオエンジニアリング講演会

Presentation date： 2016
ヒト脳動脈瘤の病理工学的検討：超微細構造による菲薄化メカニズムに関する検討

戸部泰貴, 杉浦拓磨, 須藤健太, 八木高伸, 川村公一, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

第28回バイオエンジニアリング講演会

Presentation date： 2016
Modeling of blood flow with pathology in cerebral aneurysms

Yagi T, Tobe Y, Hayashi Y, Kawamura K, Umezu M

Interdisciplinary Cerebrovascular Symposium Intracranial Stent Meeting

Presentation date： 2015
血流解析専用ソフトウェアによる未来医療への挑戦 CFDを原理から現場へ

八木高伸 [Invited]

第30回日本脳神経血管内治療学会ランチョンセミナー

Presentation date： 2015
血流を診る未来医療の創造 CFD を原理から現場へ

八木高伸 [Invited]

第46回神奈川アンギオ撮影研究会

Presentation date： 2015
オールジャパンで共創する脳動脈瘤の未来医療と技術革新

八木高伸 [Invited]

脳血管外科フォーラム

Presentation date： 2015
脳動脈瘤における流体解析の最前線

八木高伸 [Invited]

第39回兵庫県CT部会

Presentation date： 2014
脳動脈瘤の血流を診る：原理から現場へ

八木高伸 [Invited]

第14回高速らせんCT技術セミナー

Presentation date： 2014
血流解析専用ソフトウェアによる未来医療への挑戦：CFDを原理から現場へ

八木高伸 [Invited]

日本脳神経血管内治療学会ランチョンセミナー

Presentation date： 2014
化学発光を用いた溶血現象の可視化手法の検討

梅谷康太郎, 八木高伸, 中村匡徳, 岩本理沙, 手塚諒, 梅津光生

第26回バイオエンジニアリング講演会

Presentation date： 2014
衝撃せん断流によるヒト赤血球破壊に関する検討

岩本理沙, 八木高伸, 梅谷康太郎, 手塚諒, 梅津光生

第26回バイオエンジニアリング講演会

Presentation date： 2014
CFD流出境界条件の違いが脳動脈瘤内血流に及ぼす影響の検討

山梨桃子, 八木高伸, 平口心, 三登将平, 高村兼司, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

第26回バイオエンジニアリング講演会

Presentation date： 2014
脳血管バイパス術における術前・術後の血行動態に関する検討

高村兼司, 八木高伸, 山梨桃子, 片岡大治, 山本明秀, 井口智史, 飯田秀博, 佐藤洸太, 中村匡徳, 梅津光生

第26回バイオエンジニアリング講演会

Presentation date： 2014
脳動脈瘤の発生初期とされる分岐血管壁の菲薄化と血行動態に関する検討

岩渕祐貴, 八木高伸, 戸部泰貴, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

第26回バイオエンジニアリング講演会

Presentation date： 2014
流体力学によるテイラーメイド診断治療支援：現状と将来

八木高伸 [Invited]

心臓 CT セミナー

Presentation date： 2013
血流を診る医療へ：数値流体力学（CFD)を原理から現場へ

八木高伸 [Invited]

医工融合最新技術動向セミナー神戸

Presentation date： 2013
体循環シミュレータを用いたステントレス僧帽弁の開閉特性に関する検討

真鍋晋, 八木高伸, 岩﨑清隆, 加瀬川均, 梅津光生

第24回バイオフロンティア講演会

Presentation date： 2013
ヒト未破裂脳動脈瘤の瘤壁の菲薄化を術前に検知できる血流の指標化に関する検討

岩渕祐貴, 八木高伸, 戸部泰貴, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

第24回バイオフロンティア講演会

Presentation date： 2013
循環シミュレータを用いた心不全患者への補助人工心臓装着による治療効果の検討

岡田昂大, ムンソジョン, 土居徹哉, 五十嵐利博, 山崎健二, 八木高伸, 岩﨑清隆, 藤本哲男, 梅津光生

第24回バイオフロンティア講演会

Presentation date： 2013
３分岐人工血管の非臨床試験における血流配分評価法の検討

木浦千夏子, 八木高伸, 中村匡徳, 岩崎清隆, 銭逸, 奥田茂男, 吉武明弘, 志水秀行, 四津良平, 梅津光生

第51回日本人工臓器学会大会/第5回国際人工臓器学術大会

Presentation date： 2013
赤血球の伸長に応じた衝突・破壊特性

八木高伸, 岩本理沙, 梅谷康太郎, 手塚諒, 梅津光生

第51回日本人工臓器学会大会/第5回国際人工臓器学術大会

Presentation date： 2013
医工融合で加速する脳血管疾患の診断・治療の新展開：血流診断

八木高伸

MEIOS特別セミナー

Presentation date： 2012
流体力学で診る未破裂脳動脈瘤の術前壁性状予測

八木高伸 [Invited]

Non Invasive Imaging Seminar

Presentation date： 2012
流体力学が挑む次世代医療への挑戦：流れの現実と解釈

八木高伸 [Invited]

日本機械学会東海学生会第190回講演会

Presentation date： 2012
ヒト脳動脈瘤の外壁性状及び衝突流れの相関による組織菲薄化に関する検討

戸部泰貴, 八木高伸, 高橋彩来, 岩渕裕貴, 山梨桃子, 岩崎清隆, 梅津光生, 林祥史, 岡田義文, 菅原道仁, 北原茂実

第24回バイオエンジニアリング講演会

Presentation date： 2012
EFDとCFDの比較による脳動脈瘤内の血流の衝突ダイナミクスに関する研究

高橋彩来, 八木高伸, 戸部泰貴, 岩淵裕貴, 山梨桃子, 岩崎清隆, 梅津光生, 村山雄一, 高尾洋之

第24回バイオエンジニアリング講演会

Presentation date： 2012
個々の赤血球の細胞内ヘモグロビン総量を画像計測する方法に関する基礎検討

関裕子, 八木高伸, 木田大輔, 岩本理沙, 梅津光生

第24回バイオエンジニアリング講演会

Presentation date： 2012
壁面衝突する個々の赤血球のリアルタイム動態観察と溶血との関連性

八木高伸

第40回人工心臓と補助循環懇話会

Presentation date： 2012
循環器系人工臓器のマクロ・マイクロ流体解析：血液破壊を予防する次世代人工臓器を目指して

八木高伸 [Invited]

先端技術フォーラム，日本機械学会2011年度年次大会

Presentation date： 2011
脳動脈瘤の破裂を予測する医工学技術の確立に向けて

八木高伸 [Invited]

墨田区産学連携事業

Presentation date： 2011
血流解析による脳動脈瘤のテイラーメイド診断：破裂瘤の予測・予防を目指して

八木高伸 [Invited]

Japan ANSYS Conference

Presentation date： 2011
未破裂脳動脈瘤の次世代医療：血流診断による破裂瘤の予測・予防戦略

八木高伸 [Invited]

早稲田大学理工学術院総合研究所産学連携室先端研究者交流会第一回会合

Presentation date： 2011
弾性脳動脈瘤モデルを用いたステレオＰＩＶ法による壁面せん断応力3次元計測と時間・空間特性

新家学, 八木高伸, 梅津光生

第23回バイオエンジニアリング講演会

Presentation date： 2011
超高速イメージングによる衝突速度に応じたヒト赤血球のリアルタイム破壊動態解析

秋元祐紀, 八木高伸, 梅津光生

第23回バイオエンジニアリング講演会

Presentation date： 2011
脳動脈瘤内の流れの遷移性に関して：計測・計算の比較によるモデリング留意点

八木高伸, 高橋彩来, 戸部泰貴, 岩崎清隆, 梅津光生, 高尾洋之, 村山雄一

第34回日本バイオレオロジー学会年会

Presentation date： 2011
脳動脈瘤における血流の流体解析と瘤壁の電子顕微鏡所見の相関：瘤壁を菲薄化させる「悪性流れ」の特定に向けて

林祥史, 八木高伸, 梅津光生

第70回日本脳神経外科学会総会

Presentation date： 2011
循環器系DRYラボによるもう一つのEBM：Engineering Based Medicine東京女子医大・早稲田大学連携研究施設（TWIns）での事例紹介

八木高伸 [Invited]

マテリアライズカンファレンス

Presentation date： 2010
壁面衝突により座屈を伴い瞬時膜破壊に至る赤血球破壊のリアルタイム可視化計測

徳永夏子, 八木高伸, 秋元祐紀, 関裕子, 梅津光生

第22回バイオエンジニアリング講演会

Presentation date： 2010
破裂脳動脈瘤内の血流に関するマイクロスケール時空間解析：衝突ジェットによる乱流の発生

佐藤絢香, 八木高伸, 新家学, 高橋彩来, 梅津光生, 村山雄一, 高尾洋之

第22回バイオエンジニアリング講演会

Presentation date： 2010
OPCAB吻合手技訓練装置“BEAT-S1”の開発と臨床現場への展開

朴栄光, 牧野穂高, 新家学, 八木高伸, 浅野竜太, 津久井宏行, Robert L Kormos, 梅津光生

第22回バイオエンジニアリング講演会

Presentation date： 2010
補助人工心臓駆動下における心壁挙動が左心室モデル内血流に及ぼす影響の検討

久米嶺, 楠瀬俊祐, 立田良太, 五十嵐利博, 八木高伸, 岩崎清隆, 山崎健二, 梅津光生

第22回バイオエンジニアリング講演会

Presentation date： 2010
補助人工心臓駆動下における左心室内の血流の検討~in vitro試験による血流の可視化実験~

五十嵐利博, 石澤祐馬, 久米嶺, 楠瀬俊祐, 立田良太, 八木高伸, 岩崎清隆, 銭逸, 山崎健二, 梅津光生

第47回日本人工臓器学会大会

Presentation date： 2009
高速リアルタイムイメージングによる壁面衝突する個々の赤血球の衝撃・破壊解析

八木高伸, 徳永夏子, 秋元祐紀, 関裕子, 梅津光生

第47回日本人工臓器学会大会

Presentation date： 2009
高速マイクロジェットを用いた壁面衝突する赤血球の圧縮変形と破壊現象の可視化計測

八木高伸, 若狭翔太郎, 徳永夏子, 秋元祐紀, 梅津光生

計算工学講演会

Presentation date： 2009
Microfluidic analysis of erythrocyte deformation for studying flow-induced hemolysis

Yagi T, Sudo H, Akimoto Y, Umezu M

The International Journal of Artificial Organs

Presentation date： 2008
走査型ステレオPIV法を用いた異なる大動脈バルサルバ洞形状をもつValved Graft内の3次元流動特性

八木高伸, 若狭翔太郎, William Yang, 岩崎清隆, 梅津光生

日本機械学会年次大会講演論文集

Presentation date： 2007
Coil compaction予測のための時系列PIV法を用いた実形状弾性脳動脈瘤モデル内の流れの可視化

松本徹, 岩崎清隆, 八木高伸, 梅津光生

第19回バイオエンジニアリング講演会

Presentation date： 2007
ステレオPIV法を用いた大動脈バルサルバ洞内の3次元流れ場構造に関する基礎検討

須藤宏幸, 八木高伸, 石川大輔, 若狭翔太朗, Yang W, 岩崎清隆, 梅津光生

第19回バイオエンジニアリング講演会

Presentation date： 2007
リアルタイム周波数解析を用いた人工弁閉鎖時に発達する瞬時高周波ストレスの検討

石川大輔, 八木高伸, 阿久津敏乃介, 岩崎清隆, 梅津光生

第19回バイオエンジニアリング講演会

Presentation date： 2007
拍動型人工心臓内の流体構造連成を考慮した旋回流の3次元可視化解析

八木高伸, William Yang, 若狭翔太朗, 岩崎清隆, 梅津光生

第18回バイオフロンティア講演会

Presentation date： 2007
人工弁近傍の乱流が血球細胞に与える力学的負荷の特性評価

須藤宏幸, 八木高伸, 阿久津敏乃介, 岩崎清隆, 梅津光生

第18回バイオフロンティア講演会

Presentation date： 2007
Three-dimensional volume characterization of swirling flow with fluid-structure coupling in a spiral vortex pulsatile blood pump

Yagi T, Wakasa S, Yang W, Iwasaki K, Umezu M

45th JSAO&IFAO Joint Congress

Presentation date： 2007
The mechanism of turbulence: new finding of impulsively-generated compressive mechanical stress on blood cells flowing through artificial heart valves,

Yagi T, Sudo H, Akutsu T, Iwasaki K, Umezu M

45th JSAO&IFAO Joint Congress

Presentation date： 2007
中大脳動脈瘤のCFDを用いた血流比変化における動脈瘤内圧変化の検討

高尾洋之, 村山雄一, 福井弘一, 銭逸, 石橋敏寛, 北谷優太郎, 八木高伸, 岩崎清隆, 梅津光生, 阿部俊昭

第23回日本脳神経血管内治療学会総会

Presentation date： 2007
実形状・弾性モデルを用いた脳動脈瘤内の流れのリアルタイム解析：破裂瘤と未破裂瘤の流入形態の比較検討

福島桃子, 岩崎清隆, 八木高伸, 鴨田明憲, 佐藤絢香, 梅津光生, 阿久津敏之介, 高尾洋之, 石橋敏寛, 村山雄一

第23回日本脳神経血管内治療学会総会

Presentation date： 2007
脳動脈瘤の医学的問題点とバイオエンジニアリングを用いた研究の期待

高尾洋之, 村山雄一, 石橋敏寛, 八木高伸, 岩崎清隆, 銭逸, 梅津光生

適応医学

Presentation date： 2006
時系列PIV及びウェーブレット解析を応用した人工弁近傍の高せん断乱流場で発達する瞬時高周波ストレスに関する検討

石川大輔, 八木高伸, 須藤宏幸, 阿久津敏乃介, 岩﨑清隆, 梅津光生

第18回バイオエンジニアリング講演会

Presentation date： 2006
ステレオPIV法を用いたSpiral Vortex型人工心臓内の拍動流の3次元可視化解析

八木高伸, William Yang, 石川大輔, 須藤宏幸, 岩﨑清隆, 梅津光生

第18回バイオエンジニアリング講演会

Presentation date： 2006
脳動脈瘤治療法の評価を目的とした拍動循環シミュレータの開発

栗山仁志, 岩崎清隆, 八木高伸, 高島俊洋, 藤井麻由, 石川大輔, 梅津光生, 阿久津敏乃介, 高尾洋之, 石橋敏寛, 村山雄一

第17回バイオエンジニアリング講演会

Presentation date： 2005
人工弁近傍で発達する乱流に関する新評価手法の提言：時系列PIVとWavelet解析を用いた瞬時ストレスの周波数解析

八木高伸, 石川大輔, 須藤宏幸, 阿久津敏乃介, William Yang, 岩崎清隆, 梅津光生

第43回日本人工臓器学会

Presentation date： 2005
Spiral Vortex型人工心臓内の拍動流の3次元構造を実験計測するステレオPIV法の開発

八木高伸, William Yang, 石川大輔, 須藤宏幸, 岩崎清隆, 梅津光生

第43回日本人工臓器学会

Presentation date： 2005
Development of Dynamic Particle Image Velocimetry toward the study of spatio-temporal dynamics of turbulent flow in artificial heart valves

Yagi T, Ishikawa D, Akutsu T, Iwasaki K, Noguchi Y, Umezu M

International journal of artificial organs

Presentation date： 2004
Stereoscopic Particle Image Velocimetry measurements toward three dimensional flow investigations within the Spiral Vortex blood pump

Yagi T, Yang W, Ishikawa D, Iwasaki K, Umezu M

lecture notes of the ICB seminar, 7th Polish-Japanese seminar on new technologies for future artificial organs

Presentation date： 2004
Spiral Vortex型血液ポンプ内の3次元流れ解析に向けて－PIV可視化解析及び数値流体モデルによる検討

八木高伸, William Yang, 長沼寛樹, 佐藤芳行, 岩崎清隆, 梅津光生

第16回バイオエンジニアリング講演会

Presentation date： 2004
拍動型人工心臓内の流れ場の3次元構造および時系列現象を計測する新可視化技術の基礎検討

八木高伸, 石川大輔, William Yang, 阿久津敏乃介, 岩崎清隆, 野口康雄, 梅津光生

第42回日本人工臓器学会

Presentation date： 2004
Dynamic and static evaluation of two types of annuloplasty rings at mitral position using a mock circuit with fresh porcine valve

Umezu M, Iwasaki K, Arita M, Okuda M, Doi H, Yagi T, Kasegawa H, Fujimoto T

30th ESAO congress 2003 High tech and medicine

Presentation date： 2003
Development of an In Vitro Evaluation System for Mitral Annuloplasty, World Congress on Medical Physics and Biomedical Engineering

Doi H, Arita M, Okuda M, Yagi T, Iwasaki K, Umezu M

World Congress on Medical Physics and Biomedical Engineering

Presentation date： 2003
Development of a multi-purpose mock circulatory system to reproduce a mitral valve disease

Okuda M, Arita M, Doi H, Yagi T, Kasegawa H, Umezu M, Tanaka T

Asian Simulation Conf. the 5th International Conference on System Simulation and Scientific Computing

Presentation date： 2002

▼display all

Research Seeds

Reproduction model device for cerebral aneurysm

Life sciences

Research Projects

血管組織内微視的力学場の定量による瘤発生機構解明と力学環境操作による病理応答制御

日本学術振興会科学研究費助成事業

Project Year :

2022.04

-

2027.03

中村匡徳, 八木高伸, 杉田修啓, 片岡大治, 青木友浩, 氏原嘉洋
Development of an experimental method for measuring three-dimensional strain distribution in calcified coronary artery model during balloon expansion

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research

Project Year :

2021.04

-

2024.03
脳動脈瘤壁の慢性炎症と退行性変化をもたらす血行力学的因子の解明

日本学術振興会科学研究費助成事業

Project Year :

2020.04

-

2023.03

片岡大治, 八木高伸, 中村匡徳

　View Summary

令和3年度は、ラットの頚部頚動脈に動脈瘤を誘導するモデル（CCAモデル）を用いて、血管の分岐角度と、その後の脳動脈瘤増大について検討し、動脈瘤進行群で当初の分岐血管の分岐角度が有意に大きいことを報告した。また、進行群の動脈瘤の増大時期に cellular communication network factor 1 (CCN1) の発現が上昇することをprotein array analysisと免疫組織染色で明らかにした。
昨年度は、確立した破裂モデルを用いて、破裂部周囲に新生血管の増生がみられることを報告したが、令和3年度は、この血管新生に低酸素環境で誘導されるマクロファージからのvascular endothelial growth factor(VEGF)が作用していることを見いだした。また、従来の脳動脈瘤発生モデル及び破裂モデルを用いて、動脈瘤壁に集積するマクロファージの遺伝子発現profileを解析し、脳動脈瘤壁に集積するのマクロファージの役割につき、さらに詳しい検討を行っている。
ヒト脳動脈瘤による増大・破裂に関与する血行力学的因子の検証では、京都大学及び関連4施設から、観察中に増大・破裂をおこした脳動脈瘤と3年以上増大も破裂もしなかった脳動脈瘤の画像データの登録を完了し、この2群間でCase Control Studyを行った。前交通動脈瘤については、増大・破裂群27例とコントロール群65例の比較を行い、増大・破裂群で前交通動脈と前大脳動脈の分岐角度が有意に大きいことを示した。また多変量解析においても同分岐角度は増大・破裂を予測する独立した危険因子であった。現在、中大脳動脈瘤についても同様の解析を行っている。
脳動脈瘤治癒過程における血栓化ダイナミクスを説明する数理モデルの構築と臨床応用

日本学術振興会科学研究費助成事業

Project Year :

2018.07

-

2023.03

杉山由恵, 八木高伸, 中村匡徳, 石井暁, 青木友浩

　View Summary

【動物モデルによる血栓化過程】ラビットモデルに基づき、ステント留置後の血栓化過程の時系列データ取得を試みた。並行して、ラットモデルにステント留置を施し血栓化過程の観測を試みている。
【ステント留置シミュレータ】同シミュレータを開発し複数症例で安定的に留置が可能であることを確かめた。
【数理モデル】上記シミュレータと血栓形成シミュレーションに適応し、血栓化過程のシミュレーションを再現した。
Real-time quantitative prediction of cerebral-aneurysm growth with thrombosis-stratified vascular remodeling

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research

Project Year :

2019.04

-

2022.03

yagi takanobu

　View Summary

Intracranial aneurysms consisted of a coexistence of thin and thick walls, suggesting that two distinct vascular remodeling are involved, but their mechanism has yet to be clarified. This research combined human pathology, in vivo, ex vivo, and in silico experiments, and thereby aimed at understanding and modeling the mechanism. As a result, an aneurysmal progression was found to be associated with vascular strain by blood pressure. The increased wall strain due to wall thinning was associated with massive death of smooth muscle cells, resulting in a formation of microscopic tear, through which the aneurysm is enlarged morphologically. The micro tear promoted thrombus formation as a repair of vascular tissues, but the formation of thrombus has a dependence on surrounding environment. Flow impingement and concentrated wall strain were preventive factors of thrombus formation, which has a role of bifurcating the vascular remodeling in either wall-thinning or -thickening direction.
非臨床性能評価を深化する超小型血液循環シミュレータの開発

文部科学省科研費基盤B

Project Year :

2018.04

-

2021.03

梅津光生
SHG光計測による瞬時大変形した赤血球の膜損傷の可視化と損傷度の定量

文部科学省科研費基盤C

Project Year :

2018.04

-

2021.03

中村匡徳
Quantification of failure conditions of a single red blood cell by non-contact mechanical tests using MEMS and chemiluminescene reactions

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research

Project Year :

2016.04

-

2018.03

Nakamura Masanori, YAGI Takanobu

　View Summary

The present study attempted to determine the fracture strain of a single red blood cell (RBC) using non-contact mechanical tests. A crossed microchannel with a width of 50 um at the junction was fabricated. RBCs were introduced to the microchannel with expectations that RBCs are instantaneously stretched at the junction by colliding flows. The deformation behavior was observed with a microscope and recorded with a high speed camera. The amount of residual hemoglobin was estimated from the collected red blood cells based on the Lambert- Beer's law. Correlation between the maximum amount of deformation of RBCs during flow and the amount of residual hemoglobin was examined, and no correlation was found. On the other hand, a negative correlation was found between the compressive deformation rate and the residual amount of hemoglobin. These results suggested that RBSs are damaged more by compression than stretch.
新規治療機器を実臨床に導入時に有効な循環シミュレータの開発

文部科学省科研費基盤B

Project Year :

2015.04

-

2018.03

梅津光生
数値流体力学による冠動脈機能的狭窄の非侵襲診断ソフトウェアの開発

AMED Medical Artsの創成に関する研究

Project Year :

2016.04

-

2017.03

斎藤成達
数値流体力学による脳動脈瘤血管内治療リスク判定システムの開発

AMED 医工連携事業化推進事業

Project Year :

2016.04

-

2017.03

坂田隆史, 八木高伸
広領域循環シミュレータによる脳血管血行再建術支援のための血流制御機構の解明

文部科学省科研費基盤B

Project Year :

2015.04

-

2017.03

片岡大治
数値流体力学による脳動脈瘤発症リスク診断法の開発

JST ASTEP FS

Project Year :

2015.04

-

2016.03

冨永悌二
血流シミュレータによる治療困難な脳動脈瘤に対するバイパス併用術支援技術の確立

文部科学省科研費基盤C

Project Year :

2012.04

-

2014.03

片岡大治
循環器系DRYラボセンターを駆使した治療リスクの低減システム構築と人材育成

厚生労働省医療機器開発推進研究事業

Project Year :

2011.04

-

2013.03

梅津光生
臨床に直接貢献できる実用型小児先天性心疾患の血流シミュレーションシステムの構築

文部科学省科研費挑戦的萌芽

Project Year :

2009.04

-

2010.03

梅津光生
高速マイクロ流れを用いた赤血球破壊リアルタイム可視化と溶血力学モデルの実験的構築

文部科学省科研費若手B

Project Year :

2009.04

-

2010.03

八木高伸
循環器系DRYラボセンターの創設とENGINEERING BASED MEDICINEの推進

厚生労働省医療機器開発推進研究事業

Project Year :

2008.04

-

2010.03

梅津光生
-

▼display all

Misc

数値流体力学による血管障害の診断治療支援：現状と展望

八木高伸

アールティ（エーザイ株式会社） 2018 [Invited]
2E33 Study of relationship between the impingement flow and activation of thrombogenic factors using whole blood in micro-channels

TEZUKA Ryo, YAGI Takanobu, WEI Ran, UMEZU Mitsuo

2016 ( 28 ) "2E33 - 1"-"2E33-5" 2016.01

　View Summary

Relationships between impingement of blood flow and thrombus formation mechanisms in human arteries are still hypothetical. This study investigated the relationship between different conditions of impingement and thrombus formations. Impingements of whole blood were created using Y-shaped and T-shaped micro-channels that were MPC coated. The velocities of impingement were set to be 0.2 m/s and 3.0 m/s. The whole blood was obtained from a healthy male volunteer. The whole blood at the impingement area was observed with an inverted microscope and a high-speed camera. Also, areas of thrombus ware measured on the obtained images using Image-Pro Plus to quantify the thrombus volume. The results showed that thrombus formation occurred in the Y-shaped impingement flow and didn't occur in the T-shaped impingement flow in either of the velocity. The thrombus formation in the Y-shaped impingement at low velocity occurred at the position shifted to the right and left rear from the bifurcation center. The thrombus formation at high velocity occurred at the bifurcation center. In addition, thrombus at low velocity peeled off easily than at high velocity. In conclusion, it was suggested that different impingement patterns affect the formation, formation point, and detachment rate of thrombus in the micro-channels.

CiNii
循環器系疾患のための次世代診断治療支援技術：血流シミュレーション

八木高伸

インナービジョン 31 ( 10 ) 42 2016 [Invited]

Article, review, commentary, editorial, etc. (scientific journal)
健常者脳主幹動脈における壁面せん断応力一定性の検討

高西清文, 八木高伸, 八木高伸, 渡邊幹彦, 梅津光生, 中村匡徳, 林祥史, 吉田浩貴, 西谷和敏, 岡田義文, 北原茂実

バイオエンジニアリング講演会講演論文集(CD-ROM) 28th 2016

J-GLOBAL
血管吻合形状のモデル化とエネルギー損失値との関係性に関する検討

尾山大輔, PARK Young Kwang, 八木高伸, 岩崎清隆, 小坂眞一, 梅津光生

バイオエンジニアリング講演会講演論文集 28th (CD-ROM) ROMBUNNO.1E42 2016

J-GLOBAL
A110 Relationship between flow patterns and intimal structure of human cerebral aneurysms at blood-blister like lesion

Tobe Yasutaka, Sugiura Takuma, Kawamura Koichi, Yagi Takanobu, Umezu Mitsuo, Hayashi Yoshifumi, Yoshida Hirotaka, Nishitani Kazutoshi, Okada Yoshifumi, Kitahara Shigemi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering 2015 ( 26 ) 19 - 20 2015.10

CiNii
2A11 Study of relationship between hemodynamics and mural cells in thinning and thickening wall of human unruptured cerebral aneurysms

Sugiura Takuma, Yagi Takanobu, Kawamura Koichi, Tobe Yasutaka, Umezu Mitsuo, Hayashi Yoshifumi, Yoshida Hirotaka, Nishitani Kazutoshi, Okada Yoshifumi, Kitahara Shigemi

2015 ( 27 ) 301 - 302 2015.01

CiNii
2A12 Comparison of hemodynamics and infrastructure of human cerebral aneurysms

Tobe Yasutaka, Yagi Takanobu, Kawamura Koichi, Sugiura Takuma, Umezu Mitsuo, Hayashi Yoshifumi, Yoshida Hirotaka, Nishitani Kazutoshi, Okada Yoshifumi, Kitahara Shigemi

2015 ( 27 ) 303 - 304 2015.01

CiNii
2A14 Investigation of a relationship between hemodynamics and initiation of cerebral aneurysms : CFD analysis using an aneurysmal removal

Murayoshi Takuma, Tobe Yasutaka, Sugiura Takuma, Yagi Takanobu, Umezu Mitsuo, Hayashi Yoshifumi, Yoshida Hirotaka, Nishitani Kazutoshi, Okada Yoshifumi, Kitahara Shigemi

2015 ( 27 ) 307 - 308 2015.01

CiNii
1D44 Investigation of hemoglobin leakage imaging using chemiluminescence

UMETANI Kotaro, YAGI Takanobu, NAKAMURA Masanori, TEZUKA Ryo, UMEZU Mitsuo

2015 ( 27 ) 173 - 174 2015.01

CiNii
吻合手技評価フィードバックシステムの開発に向けた吻合部水平最小断面積とエネルギー損失値の関係性に関する検討

尾山大輔, PARK Young Kwang, 八木高伸, 岩崎清隆, 小坂眞一, 梅津光生

バイオエンジニアリング講演会講演論文集 27th 329 - 330 2015.01

J-GLOBAL
医学と工学を結合した日本型未来医療：流体力学を原理から現場へ

八木高伸

日本機械学会誌 118 ( 1162 ) 592 - 594 2015 [Invited]

Article, review, commentary, editorial, etc. (scientific journal)
破裂椎骨動脈解離性動脈瘤における破裂部と解離部の予測

吉田浩貴, 戸部泰貴, 林祥史, 八木高伸, 岩崎清隆, 祖母井龍, 中村真, 北原茂実

J Neuroendovascular Ther 8 ( 6 ) 387 2014.12

J-GLOBAL
1G21 Consideration of effect of CFD outflow boundary conditions on blood flow in intracranial aneurysm

YAMANASHI Momoko, YAGI Takanobu, HIRAGUCHI Shin, MITO Shohei, TAKAMURA Kenji, UMEZU Mitsuo, HAYASHI Yoshifumi, YOSHIDA Hirotaka, NISHITANI Kazutoshi, OKADA Yoshifumi, KITAHARA Shigemi

2014 ( 26 ) 219 - 220 2014.01

CiNii
1G12 Study of hemodynamics and wall thinning of branch vessel is initiation of cerebral aneurysms

Iwabuchi Yuki, Yagi Takanobu, Tobe Yasutaka, Umezu Mitsuo, Hayashi Yoshifumi, Yoshida Hirotaka, Nishitani Kazutoshi, Okada Yoshifumi, Kitahara Shigemi

2014 ( 26 ) 209 - 210 2014.01

CiNii
2E12 Investigation of hemolysis imaging technology using chemiluminescence

UMETANI Kotaro, YAGI Takanobu, NAKAMURA Masanori, IWAMOTO Risa, TEZUKA Ryo, UMEZU Mitsuo

2014 ( 26 ) 433 - 434 2014.01

CiNii
2E11 Investigation on rupture analysis of human erythrocytes in impact shear flows

IWAMOTO Risa, YAGI Takanobu, UMETANI Kotaro, TEZUKA Ryo, UMEZU Mitsuo

2014 ( 26 ) 431 - 432 2014.01

CiNii
A219 Study of hemodynamics indicator predict wall thinning area in unruptured cerebral aneurysms

Iwabuchi Yuki, Yagi Takanobu, Tobe Yasutaka, Umezu Mitsuo, Hayashi Yoshifumi, Yoshida Hirotaka, Nishitani Kazutoshi, Okada Yoshifumi, Kitahara Shigemi

Proceedings of the ... JSME Conference on Frontiers in Bioengineering 2013 ( 24 ) 85 - 86 2013.10

CiNii
体循環シミュレータを用いたステントレス僧帽弁の開閉特性に関する検討

MOON Sojung, 岡田昂大, 真鍋晋, 八木高伸, 岩崎清隆, 加瀬川均, 梅津光生

日本機械学会バイオフロンティア講演会講演論文集 24th 101 - 102 2013.10

J-GLOBAL
循環シミュレータを用いた心不全患者への補助人工心臓装着による治療効果の検討

岡田昂大, MOON Sojung, 土居徹哉, 五十嵐利博, 山崎健二, 八木高伸, 岩崎清隆, 藤本哲男, 梅津光生

日本機械学会バイオフロンティア講演会講演論文集 24th 83 - 84 2013.10

J-GLOBAL
3分岐人工血管の非臨床試験における血流配分評価法の検討

木浦千夏子, 八木高伸, 中村匡徳, 岩崎清隆, 銭逸, 奥田茂男, 吉武明弘, 志水秀行, 四津良平, 梅津光生

人工臓器(日本人工臓器学会) 42 ( 2 ) S.130 2013.09

J-GLOBAL
工学的検証手法を取り入れた補助人工心臓トラブル対策

五十嵐利博, 酒井基広, 峰島三千男, 岡田昂大, 土居徹哉, 立田良太, 楠瀬俊祐, 八木高伸, 田中隆, 岩崎清隆, 山崎健二, 梅津光生

東京都臨床工学技士会会誌 23 ( 2 ) 21 - 24 2013.02

J-GLOBAL
2C11 Investigation on collision and destruction dynamics indicator of human erythrocytes

KIDA Daisuke, YAGI Takanobu, IWAMOTO Risa, UMETANI Kotaro, UMEZU Mitsuo

2013 ( 25 ) 333 - 334 2013.01

CiNii
ヒト未破裂脳動脈瘤の瘤壁の菲薄化を術前に予測する血流診断法の確立

八木高伸, 戸部泰貴, 岩渕裕貴, 山梨桃子, 高村兼司, 岩崎清隆, 梅津光生, 林祥史, 岡田義文, 吉田浩貴, 北原茂実

バイオエンジニアリング講演会講演論文集 25th 523 - 524 2013.01

J-GLOBAL
ヒト未破裂脳動脈瘤の瘤壁の菲薄化に関する血流・病理統合解析

戸部泰貴, 八木高伸, 岩渕祐貴, 山梨桃子, 高村兼司, 岩崎清隆, 梅津光生, 林祥史, 岡田義文, 吉田浩貴, 北原茂実

バイオエンジニアリング講演会講演論文集 25th 525 - 526 2013.01

J-GLOBAL
CFD解析とSEMによる内皮細胞観察を行ったDistal PICA aneurysmの1例

吉田浩貴, 八木高伸, 岩崎清隆, 戸部泰貴, 高村兼司, 林祥史, 西谷和敏, 中島温, 岡田義文, 菅原道仁, 久保俊朗, 北原茂実

J Neuroendovascular Ther 6 ( 5 ) 293 2012.11

J-GLOBAL
未破裂脳動脈瘤における菲薄部,CFD解析及び動脈瘤周囲環境の関係

林祥史, 八木高伸, 岩崎清隆, 戸部泰貴, 岩渕祐貴, 吉田浩貴, 西谷和敏, 中島温, 岡田義文, 菅原道仁, 久保俊朗, 北原茂実

J Neuroendovascular Ther 6 ( 5 ) 187 2012.11

J-GLOBAL
大動脈の血流分配を再現する数値流体計算の出口境界条件の検討

木浦千夏子, 八木高伸, 中村匡徳, 岩崎清隆, QIAN U, 奥田茂男, 梅津光生

日本コンピュータ外科学会誌 14 ( 3 ) 404 - 405 2012.10

J-GLOBAL
Study of the measurement accuracy of phase-contrast MRI for measuring the flow rate of cerebral arteries

山梨桃子, 八木高伸, 高橋彩来, 戸部泰貴, 岩渕祐貴, 高村兼司, 岩崎清隆, 梅津光生, 平口心, 三登将平, 林祥史, 吉田浩貴, 西谷和敏, 太田禎久, 岡田義文, 菅原道仁, 久保俊朗, 北原茂実

可視化情報学会誌 32 ( Suppl.1 ) 315‐318 - 318 2012.07

CiNii J-GLOBAL
Characteristics of blood flow according to the wall appearance of human cerebral aneurysms

岩渕祐貴, 八木高伸, 高橋彩来, 戸部泰貴, 山梨桃子, 岩崎清隆, 梅津光生, 林祥史, 吉田浩貴, 西谷和敏, 太田禎久, 岡田義文, 菅原道仁, 久保俊朗, 北原茂実

可視化情報学会誌 32 ( Suppl.1 ) 313‐314 2012.07

J-GLOBAL
ヒト脳動脈瘤の瘤壁の局所的な菲薄,肥厚,硬化と流体力学:術中所見との比較

八木高伸, 戸部泰貴, 岩渕祐貴, 山梨桃子, 高村兼司, 岩崎清隆, 山本匡, 梅津光生, 平口心, 三登将平, 林祥史, 吉田浩貴, 西谷和敏, 太田禎久, 岡田義文, 菅原道仁, 久保俊朗, 北原茂実

日本バイオレオロジー学会年会プログラム・抄録集 35th 38 2012.05

J-GLOBAL
8F26 Investigation on an imaging technique for measuring intracellular hemoglobin volume of individual erythrocytes

SEKI Yuko, YAGI Takanobu, KIDA Daisuke, UMEZU Mitsuo

2012 ( 24 ) "8F26 - 1"-"8F26-2" 2012.01

CiNii
EFDとCFDの比較による脳動脈瘤内の血流の衝突ダイナミクスに関する研究

高橋彩来, 八木高伸, 戸部泰貴, 岩渕裕貴, 山梨桃子, 岩崎清隆, 梅津光生, 村山雄一, 高尾洋之

バイオエンジニアリング講演会講演論文集 24th (CD-ROM) ROMBUNNO.8F46 2012.01

J-GLOBAL
ヒト脳動脈瘤の外壁性状および衝突流れの相関による組織菲薄化に関する検討

戸部泰貴, 八木高伸, 高橋彩来, 岩渕裕貴, 山梨桃子, 岩崎清隆, 梅津光生, 林祥史, 岡田義文, 菅原道仁, 北原茂実

バイオエンジニアリング講演会講演論文集 24th (CD-ROM) ROMBUNNO.8F47 2012.01

J-GLOBAL
血流診断という次世代医療診断の確立に向けて

八木高伸

早稲田産学連携レビュー 82 - 83 2012 [Invited]

Article, review, commentary, editorial, etc. (bulletin of university, research institution)
レギュラトリーサイエンスから見た弁膜症治療の医工学的評価

梅津光生, 加瀬川均, 岩崎清隆, 八木高伸, 中村匡徳, 笠貫宏

医工学治療 24 ( Supplement ) 60 2012

J-GLOBAL
脳動脈瘤内の流れの遷移性に関して:計測・計算の比較によるモデリング留意点

八木高伸, 高橋彩来, 戸部泰貴, 岩崎清隆, 梅津光生, 高尾洋之, 村山雄一

日本バイオレオロジー学会年会プログラム・抄録集 34th 47 2011.06

J-GLOBAL
9F-07 Spatiotemporal characteristics of wall shear rate in elastic cerebral aneurysm models using 3D stereo PIV

SHINKE Manabu, SATO Ayaka, TAKAHASHI Sara, YAGI Takanobu, UMEZU Mitsuo, MURAYAMA Yuichi, TAKAO Hiroyuki

2010 ( 23 ) 403 - 404 2011.01

CiNii
先進臨床医療に貢献する医工連携

八木高伸

早稲田産学連携レビュー 31 - 32 2011 [Invited]

Article, review, commentary, editorial, etc. (bulletin of university, research institution)
in vitro試験による補助人工心臓駆動時の左心室内血流の検討

五十嵐利博, 石澤祐馬, 久米嶺, 楠瀬俊祐, 立田良太, 八木高伸, 岩崎清隆, 山崎健二, 梅津光生

体外循環技術 37 ( 4 ) 409 - 412 2010.12

J-GLOBAL
A103 Effect of posterior communicating artery on hemodynamics and rupture risk of cerebral aneurysms : 3D flow visualization study using a patient-specific elastic model of a ruptured aneurysm

TAKAHASHI Sara, YAGI Takanobu, SHINKE Manabu, UMEZU Mitsuo, MURAYAMA Yuichi, TAKAO Hiroyuki

Proceedings of the ... JSME Conference on Frontiers in Bioengineering 2010 ( 21 ) 5 - 6 2010.11

CiNii
Report on 14^<th> ISFV

YAGI Takanobu

30 ( 119 ) 243 - 243 2010.10

CiNii
0224 Real-time visualization of wall-colliding erythrocyte destruction from buckling to membrane fractrue

TOKUNAGA Natsuko, YAGI Takanobu, AKIMOTO Yuki, SEKI Yuko, UMEZU Mitsuo

2009 ( 22 ) 208 - 208 2010.01

CiNii
0814 Development of Surgical Training Simulator for Off-Pump Bypass "BEAT-S1" and its expansion into the clinical fields.

PARK Young Kwang, MAKINO Hodaka, SHINKE Manabu, YAGI Takanobu, ASANO Ryota, Tsukui Hiroyuki, Kormos Robert L., Umezu Mitsuo

2009 ( 22 ) 138 - 138 2010.01

CiNii
0223 Microscale spatiotemporal analysis of ruptured cerebral aneurysm hemodynamics : turbulence with impinging jet

SATO Ayaka, YAGI Takanobu, SHINKE Manabu, TAKAHASHI Sara, UMEZU Mitsuo, MURAYAMA Yuichi, TAKAO Hiroyuki

2009 ( 22 ) 207 - 207 2010.01

CiNii
補助人工心臓駆動下における心壁挙動が左心室モデル内血流に及ぼす影響の検討

久米嶺, 楠瀬俊祐, 立田良太, 五十嵐利博, 八木高伸, 岩崎清隆, 山嵜健二, 梅津光生

バイオエンジニアリング講演会講演論文集 22nd 57 2010.01

J-GLOBAL
脳動脈瘤の破裂を予測する医工学技術の確立に向けて

八木高伸, 銭逸, 他

人工臓器 39 ( 3 ) 227 - 231 2010 [Invited]

Article, review, commentary, editorial, etc. (scientific journal)

DOI CiNii
Report on 10^<th> International Conference on Fluid Control, Measurements, and Visualization

YAGI Takanobu

30 ( 116 ) 47 - 48 2010.01

CiNii
補助人工心臓駆動下における左心室内の血流の検討~in vitro試験による血流の可視化実験~

五十嵐利博, 石澤祐馬, 久米嶺, 楠瀬俊祐, 立田良太, 八木高伸, 岩崎清隆, 銭逸, 山崎健二, 梅津光生

人工臓器(日本人工臓器学会) 38 ( 2 ) S.150 2009.10

J-GLOBAL
in vitro試験による補助人工心臓駆動時の左心室内血流の検討

五十嵐利博, 石澤祐馬, 久米嶺, 楠瀬俊祐, 立田良太, 八木高伸, 岩崎清隆, 山嵜健二, 梅津光生

体外循環技術 36 ( 3 ) 327 2009.09

J-GLOBAL
内頸動脈に発症したSidewall型脳動脈瘤の血流学的分類―in vitro可視化実験による破裂3症例と未破裂6症例の比較検討

鴨田明憲, 八木高伸, 佐藤絢香, 銭逸, 岩崎清隆, 阿久津敏乃介, 梅津光生, 高尾洋之, 村山雄一

J Neuroendovascular Ther 2 ( 4 ) 296 2008.11

J-GLOBAL
実形状・弾性モデルを用いた脳動脈瘤内の流れのリアルタイム解析:破裂瘤と未破裂瘤の流入形態の比較検討

福島桃子, 岩崎清隆, 八木高伸, 鴨田明憲, 佐藤絢香, 梅津光生, 阿久津敏之介, 高尾洋之, 石橋敏寛, 村山雄一

J Neuroendovascular Ther 1 ( 2 ) 140 2007.11

J-GLOBAL
拍動型人工心臓内の流体構造連成を考慮した旋回流の3次元可視化解析

八木高伸, YANG William, 若狭翔太朗, 岩崎清隆, 梅津光生

日本機械学会バイオフロンティア講演会講演論文集 18th 109 - 110 2007.10

J-GLOBAL
人工心臓弁近傍の乱流が血球細胞に与える力学的負荷の特性評価

須藤宏幸, 八木高伸, 阿久津敏乃介, 岩崎清隆, 梅津光生

日本機械学会バイオフロンティア講演会講演論文集 18th 107 - 108 2007.10

J-GLOBAL
脳動脈瘤の医学的問題点とバイオエンジニアリングを用いた研究の期待

高尾洋之, 村山雄一, 石橋敏寛, 八木高伸, 岩崎清隆, 銭逸, 梅津光生

適応医学 10 ( 1 ) 21 2006.06

J-GLOBAL
ステレオPIV法を用いたSpiral Vortex型人工心臓内の拍動流の3次元可視化解析

八木高伸, YANG William, 石川大輔, 須藤宏幸, 岩崎清隆, 梅津光生

バイオエンジニアリング講演会講演論文集 18th 309 - 310 2006.01

J-GLOBAL
時系列PIV及びウェーブレット解析を応用した人工弁近傍の高せん断乱流場で発達する瞬時高周波ストレスに関する検討

石川大輔, 八木高伸, 須藤宏幸, 阿久津敏乃介, 岩崎清隆, 梅津光生

バイオエンジニアリング講演会講演論文集 18th 311 - 312 2006.01

J-GLOBAL
人工弁近傍で発達する乱流に関する新評価手法の提言:時系列PIVとWavelet解析を用いた瞬時ストレスの周波数解析

八木高伸, 石川大輔, 須藤宏幸, 阿久津敏乃介, YANG William, 岩崎清隆, 梅津光生

人工臓器(日本人工臓器学会) 34 ( 2 ) S.176-S.177 2005.11

J-GLOBAL
Spiral Vortex型人工心臓内の拍動流の3次元構造を実験計測するステレオPIV法の開発

八木高伸, YANG William, 石川大輔, 須藤宏幸, 岩崎清隆, 梅津光生

人工臓器(日本人工臓器学会) 34 ( 2 ) S.97 2005.11

J-GLOBAL
拍動型人工心臓内の流れ場の3次元構造および時系列現象を計測する新可視化技術の基礎検討

八木高伸, 石川大輔, WILLIAM Y, 阿久津敏乃介, 岩崎清隆, 野口康雄, 梅津光生

人工臓器(日本人工臓器学会) 33 ( 2 ) S.146 2004.09

J-GLOBAL
Spiral Vortex型血液ポンプ内の3次元流れ解析に向けて―PIV可視化解析及び数値流体モデルによる検討―

八木高伸, YANG W, 長沼寛樹, 佐藤芳行, 岩崎清隆, 梅津光生

バイオエンジニアリング講演会講演論文集 16th ( 16 ) 245 - 246 2004.01

CiNii J-GLOBAL

▼display all

Industrial Property Rights

血管病の病態再構築に関する方法、疾患モデル及び装置

八木高伸, 坂口勝久, 亀岡洋一郎

Patent
漏出検出センサおよび薬液注入システム

朴栄光, 八木高伸, 小野世一, 川辺朋之, 伊藤達也

Patent
ミキシングデバイス、ミキシングチューブ、薬液注入システム及び薬液の混合方法

八木高伸, 朴栄光, 梅津光生

Patent
気管チューブ、膨張性カフ、及び封止部材

森岡宣伊, 永井美玲, 尾崎眞, 八木高伸, 石井裕之, 高西淳夫, 戸部泰貴

Patent
血流性状診断のためのシステム、その方法及びコンピュータソフトウエアプログラム

八木高伸, 朴栄光

Patent
血管内治療シミュレーション装置及び方法

八木高伸, 星雄陽

Patent
血管形状分析装置、その方法、及びそのコンピュータソフトウェアプログラム

八木高伸, 中本将彦

Patent
病変血流特徴量可視化装置、その方法、及びそのコンピュータソフトウェアプログラム

八木高伸

Patent
組織血管特性を可視化するための方法及びその装置

八木高伸

Patent
血管病変発症・成長予測装置及び方法

八木高伸

Patent
血流解析装置、その方法、及びそのコンピュータソフトウェアプログラム

八木高伸

Patent
漏出検出センサおよび薬液注入システム

朴栄光, 八木高伸, 小野世一, 川辺朋之, 伊藤達也

Patent
血管形状構築装置、その方法及びコンピュータソフトウエアプログラム

八木高伸, 中本将彦, 朴栄光

Patent
血管治療評価システム、そのコンピュータソフトウエアプログラム及び方法

八木高伸, 朴栄光

Patent
血流シミュレーションのための血流解析機器、その方法及びコンピュータソフトウエアプログラム

八木高伸, 朴栄光

Patent
血流シミュレーションのための血流解析機器、その方法及びコンピュータソフトウエアプログラム

八木高伸, 朴栄光

Patent
血流シミュレーションのための血管形状構築装置、その方法及びコンピュータソフトウエアプログラム

八木高伸, 朴栄光

Patent
ミキシングデバイス、ミキシングチューブ、薬液注入システム及び薬液の混合方法

八木高伸, 朴栄光, 梅津光生

Patent
血流性状診断のためのシステム、その方法及びコンピュータソフトウエアプログラム

八木高伸, 朴栄光

Patent
血管治療効果の血流シュミレーションシステム、その方法及びコンピュータソフトウエアプログラム

八木高伸, 朴栄光

Patent
血管血流シュミレーションシステム、その方法及びコンピュータソフトウエアプログラム

八木高伸, 朴栄光

Patent
血流性状診断のためのシステム、その方法及びコンピュータソフトウエアプログラム

八木高伸, 朴栄光

Patent
漏出検出センサおよび薬液注入システム

朴栄光, 八木高伸, 小野世一, 川辺朋之, 伊藤達也

Patent
ミキシングデバイス、ミキシングチューブ、薬液注入システム及び薬液の混合方法

八木高伸, 朴栄光, 梅津光生

Patent

▼display all

Syllabus

Bioengineering

School of Creative Science and Engineering

2024 fall semester

Teaching Experience

医用機械工学研究

早稲田大学
臨床医工学概論

早稲田大学
臓器工学特論

早稲田大学
フルーイドダイナミクス

早稲田大学
メカニカルエンジニアリングラボ

早稲田大学

Sub-affiliation

Faculty of Science and Engineering School of Creative Science and Engineering