Updated on 2022/05/26

写真a

 
KUMANO, Hiroaki
 
Affiliation
Faculty of Human Sciences, School of Human Sciences
Job title
Professor

Concurrent Post

  • Faculty of Human Sciences   Graduate School of Human Sciences

  • Affiliated organization   Global Education Center

Research Institute

  • 2019
    -
    2023

    応用脳科学研究所   プロジェクト研究所所長

Education

  •  
    -
    1985

    The University of Tokyo   Faculty of Medicine   School of Medicine  

Degree

  • 東京大学   博士(医学)

  • The University of Tokyo   PhD of Medical Science

 

Research Areas

  • Clinical psychology

  • General internal medicine

  • Psychiatry

  • Nutrition science and health science

Papers

  • Self-focused attention related to social anxiety during free speaking tasks activates the right frontopolar area

    Nozomi Tomita, Hiroaki Kumano

    Current Psychology    2021.09  [Refereed]

    Authorship:Last author

     View Summary

    <title>Abstract</title>Self-focused attention (SFA) and other-focused attention (OFA) are central maintenance factors of social anxiety. Tomita et al., Cognitive Therapy and Research 44:511–525, 2020 investigated brain activities when manipulating SFA and OFA during speech tasks, after controlling for social anxiety, using near-infrared spectroscopy (NIRS) and eye-tracking. Compared with the control condition, the SFA condition demonstrated greater activity in the right frontopolar area (rFPA) and right dorsolateral prefrontal cortex. In the OFA condition, relative to controls, activity was greater in the left superior temporal gyrus. We investigated whether the activity in these brain areas increased in healthy individuals in proportion to their social anxiety tendency without manipulating SFA and OFA. Thirty-nine participants performed speech tasks under a no attentional manipulation (no-instruction) condition and a control (looking at various places) condition. Brain activity was measured using NIRS (oxy-Hb responses), and eye movements were tracked. We found that higher social anxiety was associated with higher rFPA activity in the no-instruction condition compared to the control condition and that higher subjective SFA during the no-instruction condition with higher social anxiety was associated with increased rFPA between the no-instruction and control conditions. These results suggest that greater activity in the rFPA is a useful objective measure of SFA related to social anxiety during speech tasks.

    DOI

  • Measuring Momentary Experiential Avoidance in Daily Life: A Preliminary Investigation for a New Contingency-Based Measurement Framework

    Taiki SHIMA, Kazuya INOUE, Takashi MUTO, Hiroaki KUMANO

    Journal of Evidence-Based Psychotherapies   21 ( 1 ) 113 - 132  2021.03  [Refereed]  [International journal]

     View Summary

    "This preliminary investigation aims to develop a new measure for
    momentary experiential avoidance in daily life using ecological momentary
    assessment (EMA) and a small sample. To measure momentary experiential
    avoidance, this study devised a new method that involves capturing
    reductions in unwanted experiences after a behavior has occurred based on
    negative reinforcement characteristics. A daily life investigation on students (N = 25) indicated that although “a momentary experiential avoidance index” did not correlate with acceptance and commitment therapy or symptomrelated questionnaires, it could partially predict a decrease in “irritation” and an increase in “satisfaction” after a behavior that is measured separately from an unpleasant private experience preceding the behavior. Moreover, the momentary experiential avoidance index predicted a number of positive mood states only in a group with high global experiential avoidance defined by a self-report questionnaire. Although the momentary experiential avoidance index may measure one aspect of experiential avoidance, consistent results were not obtained. Thus, this preliminary investigation only suggests the potential of expanding the measurement framework and reveals issues that require further examination."

    DOI

  • Effects of the Attention Training Technique on Brain Activity in Healthy University Students Assessed by EEG Source Imaging

    Kaori Usui, Issaku Kawashima, Nozomi Tomita, Toru Takahashi, Hiroaki Kumano

    Psychological Reports     003329412098810 - 003329412098810  2021.02  [Refereed]  [International journal]

     View Summary

    This study aimed to investigate the neurocognitive effects of the Attention Training Technique (ATT) on brain activity in healthy participants. The participants included 20 university students who were asked to practice ATT as a homework assignment for 20 days. The intracerebral source localization of their electroencephalogram during rest and the ATT task, which comprised selective attention, attention switching, and divided attention conditions, was evaluated by standardized low-resolution brain electromagnetic tomography. Brain activity during rest was subtracted from that during the ATT task, and that was compared before and after the homework assignment. The results for the divided attention condition indicated significantly decreased alpha 1 frequency band power in the left orbital frontal cortex (OFC) and alpha 2 power in the right inferior temporal cortex. Further, decreased alpha 1 power in the left OFC correlated with reduced subjective difficulty during the divided attention condition. One possibility is that the brain activity changed as the effect of ATT practice, although this study cannot confirm causality. Further studies are required which include a control group that would complete similar training without the ATT task.

    DOI

  • Learning from the Process of Introducing Online Cognitive and Behavioral Therapies at a Primary Care Psychosomatic Clinic during the Novel Coronavirus Pandemic

    Kumano Hiroaki, Tomita Nozomi, Nitta Yusuke, Oguchi Mana, Minamide Ayumi, Uchida Taro, Takei Yuki, Enomoto Kotomi, Umezu Chika

    Japanese Journal of Behavioral and Cognitive Therapies    2021

     View Summary

    <p>We describe the process of introducing online cognitive and behavioral therapies at a primary care psychosomatic clinic during the novel coronavirus pandemic. The preparation period was relatively short, due to some helpful references and the use of "Zoom," the off-the-shelf web conference service. In total, 92 sessions were implemented over six months for 22 cases, whose diagnoses and intervention methods were similar to those used in in-person counseling. There were no dropout cases, and the sustained rate was higher than that of the last year. Concerning the intervention's quality, the patients' satisfaction level was as high as it was last year, with both the main and sub-therapists reporting more merits than demerits. Significant effects were observed on first-grade master's course students through the attendance training, which should be prioritized as a new form of clinical training.</p>

    DOI CiNii

  • Interactions between subjective sleep states and multiple moods in daily life of university students

    Enomoto Kotomi, Oguchi Mana, Guan Siqing, Nitta Yusuke, Takahashi Toru, Kumano Hiroaki

    Japanese Journal of Behavioral Medicine   26 ( 1 ) 34 - 44  2021

    DOI CiNii

  • Relationship between depression, rumination, worry and executive function from the view point of metacognitive therapy

    Hiroto IKEDA, Ayumi UMEDA, Yuma FUJISHIMA, Eriko TAKAHASHI, Kodai MATSUNO, Hiroaki KUMANO

    Japanese Journal of Behavioral Medicine   25 ( 2 ) 207 - 215  2020.12  [Refereed]  [Domestic journal]

    Authorship:Last author

    DOI

  • Development of the Metacognitive Beliefs about Maladaptive Coping Behavior Scale and Examination of its Reliability and Validity

    FUJISHIMA Yuma, IKEDA Hiroto, UMEDA Ayumi, TAKAHASHI Eriko, TOMITA Nozomi, KUMANO Hiroaki

    Japanese Journal of Behavioral Medicine   25 ( 2 ) 227 - 235  2020.12  [Refereed]

    Authorship:Last author

    DOI

  • Case report of successful cognitive behavioral therapy for work adjustment and processing of non lethal trauma for man in twenties with autistic spectrum disorder: Support through skill training and imagery rescripting.

    Yusuke Nitta, Kotomi Enomoto Mari Kitahara Junichi Saito, Hiroaki Kumano

    Japanese Journal of Behavioral Medicine   25 ( 2 ) 236 - 245  2020.12  [Refereed]

    DOI CiNii

  • Reliability and Validity of the Implicit Relational Assessment Procedure (IRAP) as a Measure of Change Agenda

    Kazuya Inoue, Taiki Shima, Madoka Takahashi, Steve K. Lee, Tomu Ohtsuki, Hiroaki Kumano

    The Psychological Record   70 ( 3 ) 499 - 513  2020.09  [Refereed]  [International journal]

    Authorship:Last author

     View Summary

    This research examined the reliability and validity of the Change Agenda Implicit Relational Assessment Procedure (CA-IRAP). Change agendas that lead people to think that "reducing or removing undesirable thoughts and feelings will solve problems and lead to a more successful life" are considered unworkable in acceptance and commitment therapy (ACT). For acceptance-based interventions to succeed, relinquishing change agendas is important. However, currently available methods for measuring these types of change agendas are limited to explicit measures, which are vulnerable to distortion from social desirability and demand characteristics. The authors attempted to measure change agendas using the IRAP. A total of 131 undergraduate and graduate students (40 male, 91 female; mean age = 21.93,SD= 3.19) participated. First, we examined the CA-IRAP's discriminant validity in relation to explicit measures such as the Acceptance and Action Questionnaire-II in 83 participants who were able to pass the CA-IRAP. The correlations between the CA-IRAP and the explicit measures were low, confirming the discriminant validity of the CA-IRAP. Second, we examined the predictive validity of the CA-IRAP. Nineteen respondents had learned ACT and 34 respondents had never learned ACT. Non-ACT learners' CA-IRAP scores were higher than those of ACT learners, which confirmed the CA-IRAP's predictive validity. Finally, we examined the CA-IRAP's test-retest reliability, which was confirmed across some CA-IRAP trial types. In conclusion, the authors submit that the CA-IRAP has strong potential as a valid instrument for measuring the relative strength of relational responses around change agendas while controlling for variables such as demand characteristics.

    DOI

  • スキーマ療法におけるイメージ書き直し実施中の患者の体験プロセス 1事例の課題分析による予備的検討

    仁田 雄介, 村田 倫一, 大島 郁葉, 齋藤 順一, 平松 洋一, 河崎 智子, 吉田 斎子, 本郷 美奈子, 北原 万莉, 清水 栄司, 熊野 宏昭

    日本心理学会大会発表論文集   84回   68 - 68  2020.08

  • 日常生活下におけるセルフコンパッションおよびマインドフルネスが、その後の気分に及ぼす影響の検討

    内田 太朗, 高橋 徹, 仁田 雄介, 熊野 宏昭

    日本心理学会大会発表論文集   84回   77 - 77  2020.08

  • 事象関連電位P300を用いた能動的注意制御機能の測定課題の開発

    朴木 優斗, 管 思清, 小口 真奈, 高橋 徹, 仁田 雄介, 富田 望, 熊野 宏昭

    日本心理学会大会発表論文集   84回   103 - 103  2020.08

  • Dispositional Mindfulness Mediates the Relationship Between Sensory-Processing Sensitivity and Trait Anxiety, Well-Being, and Psychosomatic Symptoms.

    Toru Takahashi, Issaku Kawashima, Yusuke Nitta, Hiroaki Kumano

    Psychological reports   123 ( 4 ) 1083 - 1098  2020.08  [Refereed]  [International journal]

     View Summary

    Recent studies have suggested that sensory-processing sensitivity correlates to poor psychological and physical health. However, it remains unclear how this occurs. Sensory-processing sensitivity can be understood as sensitivity to sensations without the presence of intentional awareness and a nonreactive attitude, which are the components of mindfulness. We tested the hypothesis that dispositional mindfulness mediates the relationship between sensory-processing sensitivity and trait anxiety, well-being and psychosomatic symptoms. We analyzed data from 563 participating young adults living in Japan. Multiple mediation analysis showed that the four facets (nonreactivity, nonjudging, describing, and acting with awareness) of mindfulness partially mediated the effects of sub-factors of sensory-processing sensitivity (low sensory threshold and ease of excitation) on trait anxiety. Nonreactivity, describing, and acting with awareness partially mediated the effect of low sensory threshold on well-being and fully mediated the effect of ease of excitation. Nonjudging and acting with awareness partially mediated the effects of low sensory threshold and ease of excitation on psychosomatic symptoms. As a whole, the mediation hypotheses were supported, and it was determined that the improvement of dispositional mindfulness may prove effective for the psychological and physical problems of people with high sensory-processing sensitivity.

    DOI PubMed

  • Changes in Mind-Wandering and Cognitive Fusion Through Mindfulness Group Therapy for Depression and Anxiety

    Toru Takahashi, Tomoki Kikai, Fukiko Sugiyama, Issaku Kawashima, Ayaka Kuroda, Kaori Usui, Wakana Maeda, Taro Uchida, Siqing Guan, Mana Oguchi, Hiroaki Kumano

    Journal of Cognitive Psychotherapy   34 ( 2 ) 162 - 176  2020.05

     View Summary

    The mechanisms of efficacy in mindfulness-based interventions for depression and anxiety are not fully understood. To clarify these mechanisms, we tested the hypotheses that mind-wandering, daydreaming, cognitive fusion, and experiential avoidance will decrease through mindfulness group therapy, and this decrease will correlate with improvements in depression and anxiety. Participants self-reported depression and/or anxiety (<italic>N</italic> = 28) took part in an 8-week mindfulness group therapy program. They were assessed using self-report scales at pre- and post-intervention, and at 2-month follow-up. Results indicated that depression and trait-anxiety decreased between pre- and post-intervention with moderate effect sizes, which were maintained at follow-up. Mind-wandering and cognitive fusion also decreased between pre- and post-intervention with small to moderate effect sizes, and maintained at follow-up. The decreases in mind-wandering and cognitive fusion moderately correlated with improvements in depression and anxiety, suggesting that decreases in mind-wandering and cognitive fusion might underlie efficacious mechanisms of mindfulness group therapy.

    DOI

  • Developing the Metacognition of Focused Attention in Subjects with High Social Anxiety Questionnaire

    Nozomi Tomita, Ayumi Minamide, Hiroaki Kumano

    Japanese Journal of Behavioral Medicine   25 ( 1 ) 3 - 13  2020.05  [Refereed]

     View Summary

    Previous studies have demonstrated that when faced with stimuli in the form of internal or external threats, people with social anxiety exhibit attentional bias as a result of their metacognitive strategies. This study developed the Metacognition of Focused Attention in Subjects with High Social Anxiety Questionnaire (MFAQ) and investigated its reliability and validity. The MFAQ consists of positive and negative metacognitive beliefs regarding self-focused attention and attention bias. A total of 253 undergraduates completed the MFAQ and several questionnaires measuring social anxiety, internal and external attention bias, and metacognitive beliefs. Exploratory and confirmatory factor analyses were performed to identify factors and determine structural validity, and Cronbach's alpha was calculated to examine internal consistency. Correlation analyses were performed to indicate criterion-related validity and construct validity. Reliability was verified using the test-retest method within a 2-week intervening period. Consequently, factor analyses identified four factors. The alpha scores for each factor indicated good internal consistency. The MFAQ demonstrated good test-retest reliability. Criterion-related validity and construct validity were indicated except for "positive metacognition of self-focused attention." The MFAQ may prove useful in assessing the relationship between self-focused attention and attention bias in social anxiety.

    DOI

  • Influence of Experiential Avoidance on Frequency of Abdominal Pain and Abdominal Bloating in Adult Women who are Aware of Constipation

    Sanae Saito, Taiki Shima Nozomi Tomita, Ruriko Tsushima, Hiroaki Kumano

    Japanese Journal of Psychosomatic Medicine   60 ( 4 ) 339 - 348  2020.04  [Refereed]

    Authorship:Last author

    DOI

  • Avoidance Behavior Prevents Modification of Fear Memory During Reconsolidation.

    Yusuke Nitta, Toru Takahashi, Tomosumi Haitani, Eriko Sugimori, Hiroaki Kumano

    Psychological reports   123 ( 2 ) 224 - 238  2020.04  [Refereed]  [International journal]

     View Summary

    Several studies have revealed that fear recovery is prevented when extinction training is conducted after retrieval of a fear memory. Postretrieval extinction training is related to modification of memory during reconsolidation. Providing new information during reconsolidation can modify the original memory. We propose that avoidance behavior is a relevant factor that prevents subjects from obtaining new safety information during reconsolidation. Postretrieval extinction training without avoidance behavior reduced the fear response to conditioned stimulus and prevented spontaneous recovery in the current study, which corresponded with previous studies. Under the condition of postretrieval extinction training with avoidance behavior, the fear response was not reduced as much as it was in the condition without avoidance. It is possible that avoidance behavior prevents receiving new safety information during postretrieval extinction training.

    DOI PubMed

  • Development of a method of measuring self-compassionate behavior in daily life

    Uchida Taro, Takahashi Toru, Nitta Yusuke, Kumano Hiroaki

    Japanese Journal of Behavioral Medicine   25 ( 0 ) 24 - 34  2020  [Refereed]

     View Summary

    The purpose of the current study was to develop a method of measuring self-compassionate behaviors(SCBs) in daily life based on the framework of functional analysis in clinical behavior analysis. The current study used theEcological Momentary Assessment, which is a method of recording events and behaviors in daily life. Multi-level simpleregression analysis revealed that most of the items classified as SCBs significantly predicted an increase in state selfcompassion60 minutes after SCBs. In addition, most of the items classified as SCBs significantly predicted an increase inacceptance. However, most of the items classified as SCBs did not predict an increase in well-being. The method ofmeasuring SCBs in daily life developed in this study may present a new paradigm for the study of self-compassion.Moreover, this method should be a clinically useful method of measuring SCBs as it enables the assessment of changes inSCBs in daily life following an intervention. Further research is needed to examine the relationship between SCBs andwell-being in detail.

    DOI CiNii

  • Neural correlates supported by eye movements of self-focused attention and other-focused attention in social situations

    N. Tomita, A. Minamide, H. Kumano

    Cognitive Therapy and Research   44 ( 3 ) 511 - 525  2020.01  [Refereed]

    DOI

  • Relationships between Cortically Mediated Attentional Dysfunction and Social Anxiety, Self-focused Attention and External Attention Bias

    Tomita N, Imai S, Kanayama Y, Kumano H

      126 ( 6 ) 1101 - 1116  2019.12  [Refereed]  [International journal]

    Authorship:Last author

    DOI

  • Relation between Imagery Rescripting of Fear Memory and Memory Reconsolidation

    Yusuke Nitta, Toru Takahashi, Hiroaki Kumano

    Anxiety Disorder Research   11 ( 1 ) 2 - 12  2019.11  [Refereed]

    DOI

  • Does visual scanpath reflect self-focused and other-focused attention, a maintenance factor of social anxiety?

    N. Tomita, A. Minamide, H. Kumano

       2019.09

    DOI

  • 日常生活場面におけるセルフコンパッション行動の測定の試み

    内田 太朗, 高橋 徹, 仁田 雄介, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   45回   177 - 178  2019.08

  • 抑うつ傾向とマインドワンダリングの意図性

    管 思清, 高橋 徹, 仁田 雄介, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   45回   207 - 208  2019.08

  • 事象関連電位P300で測定した能動的注意制御機能と、抑うつおよび不安との関連性の検討

    朴木 優斗, 管 思清, 高橋 徹, 仁田 雄介, 小口 真奈, 熊野 宏昭, 富田 望

    日本認知・行動療法学会大会プログラム・抄録集   45回   267 - 268  2019.08

  • イメージによる記憶再固定化プロセスの生起に関する予備的検討

    仁田 雄介, 阿賀 千夏, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   45回   323 - 324  2019.08

  • 日常生活場面における入眠後3時間の徐波睡眠と気分の因果の方向性についての検討

    榎本 ことみ, 立石 七海, 高橋 徹, 管 思清, 小口 真奈, 仁田 雄介, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   45回   333 - 334  2019.08

  • ADHD傾向者における先延ばし行動が睡眠に及ぼす影響の検討

    小口 真奈, 高橋 徹, 仁田 雄介, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   45回   379 - 380  2019.08

  • Altered auditory feedback perception following an 8-week mindfulness meditation practice

    Miyashiro D, Toyomura A, Haitani T, Kumano H

    International Journal of Psychophysiology   138   38 - 46  2019.04  [Refereed]

     View Summary

    Our own ongoing motor actions are perceived through sensory feedback pathways, and are integrated with neural processes to modulate further actions. This sensory feedback mechanism is known to contribute to the rehabilitation of impaired motor functions. Recent evidence also suggests that mindfulness meditation improves our awareness to sensation; therefore, enhancement of awareness to sensory feedback through mindfulness meditation training may have potential clinical applications. This study investigated an effect of eight-week practice of mindfulness meditation on speech perception/production processes. Among the thirty healthy participants, half of them engaged in regular meditation practice of 10 min per day for eight weeks, and the other half were not given any instructions for their daily life. The change of speech performance in sentence reading under 200 ms delayed auditory feedback (DAF) condition were assessed compared to without delay condition. Also, event-related potential response to the short sound of /a/, were measured. The result showed that, after the eight-week practice, the meditation group showed significantly improved speech fluency in the DAF condition, when 16-min meditation was introduced before the experiments. Furthermore, significantly increased auditory evoked potentials were observed in the central-parietal region when the participants listened to the delayed auditory feedback sound of their own voice. These findings provide the first glimpses into the possible relationship between mindfulness meditation and auditory feedback. Different instructions for daily activity between the meditation and control groups should be considered in further studies.

    DOI

  • Changes in depression and anxiety through mindfulness group therapy in Japan: the role of mindfulness and self-compassion as possible mediators

    Takahashi T, Sugiyama F, Kikai T, Kawashima I, Guan S, Oguchi M, Uchida T, Kumano H

    BioPsychoSocial Medicine   13 ( 4 )  2019.02  [Refereed]

    DOI

  • A review of effects of compassion training on fears of compassion

    Uchida Taro, Nitta Yusuke, Takahashi Toru, Kumano Hiroaki

    The Proceedings of the Annual Convention of the Japanese Psychological Association   83 ( 0 ) 3D - 024-3D-024  2019

    DOI CiNii

  • Attempt of voluntary attention control function measurement by event-related potential P300

    Honoki Yuto, Guan Siqing, Takahashi Toru, Nitta Yusuke, Oguchi Mana, Kumano Hiroaki

    The Proceedings of the Annual Convention of the Japanese Psychological Association   83 ( 0 ) 3C - 044-3C-044  2019

    DOI CiNii

  • 注意の偏りが社交不安傾向に及ぼす影響

    南出歩美, 平 結衣, 新川瑶子, 佐々木瞳, 長澤さやか, 谷沢典子, 熊谷真人, 富田 望, 熊野宏昭

    早稲田大学臨床心理学研究   18 ( 1 ) 45 - 50  2018.12  [Refereed]

  • ACTの介入により、10年継続していた体験の回避の減少がみられた一例

    立石 七海, 臼井 香, 齋藤 順一, 仁田 雄介, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   44回   140 - 141  2018.10

  • 入眠時注意制御尺度の作成と信頼性・妥当性の検討―大学生を対象とした検討―

    荒木美乃里, 富田 望, 熊野宏昭

    行動医学研究   24 ( 1 ) 2 - 11  2018.08  [Refereed]

  • The reliability and validity for Japanese type 2 diabetes patients of the Japanese version of the acceptance and action diabetes questionnaire

    Saito J, Shoji W, Kumano H

    BioPsychoSocial Medicine   12 ( 9 ) 1 - 7  2018.04  [Refereed]

     View Summary

    BACKGROUND:
    The purpose of this study was to determing which psychological traits of Japanese type 2 diabetes patients would provide reliability and validity to the Japanese version of the Acceptance and Action Diabetes Questionnaire (AADQ-J).
    METHODS:
    Various questionnaires were administered to type 2 diabetes patients who were registered on the database of the research service provider; data from a total of 600 patients (mean ± SD age was 57.50 ± 9.87 years, female 21.83%) were analyzed.
    RESULTS:
    Three items were excluded because of psychometric concerns related to the original 11-item AADQ. Confirmation factor analyses revealed that the eight-item version demonstrated the best indicators of a goodness of fit. The questionnaire showed adequate internal consistency. The questionnaire demonstrated high measurement accuracy in broad trait values by the test information function of Item Response Theory. The questionnaire showed stronger positive correlations with self-care activities and HbA1c than with diabetes distress and depressive mood.
    CONCLUSIONS:
    The eight-item Japanese version of AADQ has reliability and validity for type 2 diabetes patients.

    DOI

  • 社交不安症における心的視点尺度の開発

    富田 望, 嶋 大樹, 熊野宏昭

    心身医学   58 ( 1 ) 65 - 73  2018  [Refereed]

  • Development of the Change Agenda Questionnaire and Evaluation of its Reliability and Validity

    Taiki SHIMA, Nozomi TOMITA, Madoka TAKAHASHI, Hiroaki KUMANO

    行動医学研究   23 ( 2 ) 103 - 110  2018  [Refereed]

  • Altered Gamma-Band Activity as a Potential Biomarker for the Recurrence of Major Depressive Disorder.

    Tetsuya Yamamoto, Nagisa Sugaya, Greg J Siegle, Hiroaki Kumano, Hironori Shimada, Sergio Machado, Eric Murillo-Rodriguez, Nuno B Rocha, Antonio E Nardi, Masahiro Takamura, Yasumasa Okamoto, Shigeto Yamawaki

    Frontiers in psychiatry   9   691 - 691  2018  [Refereed]  [International journal]

     View Summary

    Background: The neurophysiological mechanisms of cognitive reactivity, the primary vulnerability factor of major depressive disorder (MDD) recurrence, remain unclear in individuals with recovered MDD (rMDD). Because gamma-band responses (GBRs) can be used to measure cognitive processing, they may also be useful for elucidating the mechanisms underlying cognitive reactivity. Identifying these mechanisms may permit the development of an index for predicting and preempting MDD recurrence. Here, to identify the neurophysiological mechanisms of cognitive reactivity, we examined the characteristics of the GBRs evoked/induced by emotional words in participants with and without rMDD after inducing a negative mood. Methods: Thirty-three healthy control participants and 18 participants with rMDD completed a lexical emotion identification task during electroencephalography along with assessments of cognitive reactivity after negative mood induction. Results: No between-group differences were identified for the task reaction times; however, the rMDD group had significantly higher cognitive reactivity scores than did the control group. Furthermore, the power of late GBRs to positive words was significantly greater in the rMDD group, with the greater power of late GBRs being related to higher cognitive reactivity. Limitations: Considering the population studied, our findings cannot be completely generalized to populations other than adolescents, people with rMDD, and those without a history of co-morbid disorders and early life stress. Conclusions: Our findings indicate that the dysfunction of neural circuits related to higher-order processes like memory and attention might underlie cognitive reactivity. Altered late GBRs to positive information may be persistent biomarkers of the depression recurrence risk.

    DOI PubMed

  • チャルーン・サティ瞑想が大学生の注意課題中の脳活動と抑うつ傾向に与える影響の検討

    鄭 河敏, 高橋 徹, 甲斐 圭太郎, 立石 七海, 灰谷 知純, 鈴木 佑梨, 仁田 雄介, 川島 一朔, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   43回   271 - 272  2017.09

  • イメージ書き換えと記憶再固定化の関連に関する文献レビュー及び理論的考察

    仁田 雄介, 高橋 徹, 灰谷 知純, 立石 七海, 川島 一朔, 鈴木 佑梨, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   43回   429 - 430  2017.09

  • 感覚処理感受性と心身の健康の関係におけるマインドフルネス傾向の媒介効果

    高橋 徹, 灰谷 知純, 川島 一朔, 仁田 雄介, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   43回   449 - 450  2017.09

  • 失恋に関する自伝的記憶の再固定化進行中のアップデート

    立石 七海, 仁田 雄介, 高橋 徹, 灰谷 知純, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   43回   515 - 516  2017.09

  • 通級指導教室に通う児童の困難特徴および認知発達特性の理解 発達障害特性を持つ児童への効果的な支援に向けた第一段階の検討

    鈴木 佑梨, 坂本 條樹, 齋藤 文子, 岡部 泉太郎, 石井 裕美, 鈴木 潜, 皆山 由佳, 灰谷 知純, 川島 一朔, 高橋 徹, 仁田 雄介, 今井 正司, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   43回   531 - 532  2017.09

  • Prediction of Mind-Wandering with Electroencephalogram and Non-linear Regression Modeling

    Issaku Kawashima, Hiroaki Kumano

    FRONTIERS IN HUMAN NEUROSCIENCE   11  2017.07  [Refereed]

     View Summary

    Mind-wandering (MW), task-unrelated thought, has been examined by researchers in an increasing number of articles using models to predict whether subjects are in MW, using numerous physiological variables. However, these models are not applicable in general situations. Moreover, they output only binary classification. The current study suggests that the combination of electroencephalogram (EEG) variables and non-linear regression modeling can be a good indicator of MW intensity. We recorded EEGs of 50 subjects during the performance of a Sustained Attention to Response Task, including a thought sampling probe that inquired the focus of attention. We calculated the power and coherence value and prepared 35 patterns of variable combinations and applied Support Vector machine Regression (SVR) to them. Finally, we chose four SVR models: two of them non-linear models and the others linear models; two of the four models are composed of a limited number of electrodes to satisfy model usefulness. Examination using the held-out data indicated that all models had robust predictive precision and provided significantly better estimations than a linear regression model using single electrode EEG variables. Furthermore, in limited electrode condition, non-linear SVR model showed significantly better precision than linear SVR model. The method proposed in this study helps investigations into MW in various little-examined situations. Further, by measuring MW with a high temporal resolution EEG, unclear aspects of MW, such as time series variation, are expected to be revealed. Furthermore, our suggestion that a few electrodes can also predict MW contributes to the development of neuro-feedback studies.

    DOI

  • 福島原発事故により避難指示の指定を受けた被災者の心的外傷後ストレス症状

    小牧 久見子, 持田 隆平, 岩垣 穂大, 石川 則子, 赤野 大和, 福田 千加子, 桂川 泰典, 増田 和高, 多賀 努, 小島 隆矢, 扇原 淳, 根ヶ山 光一, 熊野 宏昭, 辻内 琢也

    心身医学   57 ( 6 ) 684 - 684  2017.06

  • Use of Multichannel Near Infrared Spectroscopy to Study Relationships Between Brain Regions and Neurocognitive Tasks of Selective/Divided Attention and 2-Back Working Memory

    Nozomi Tomita, Shoji Imai, Yusuke Kanayama, Issaku Kawashima, Hiroaki Kumano

    PERCEPTUAL AND MOTOR SKILLS   124 ( 3 ) 703 - 720  2017.06  [Refereed]

     View Summary

    While dichotic listening (DL) was originally intended to measure bottom-up selective attention, it has also become a tool for measuring top-down selective attention. This study investigated the brain regions related to top-down selective and divided attention DL tasks and a 2-back task using alphanumeric and Japanese numeric sounds. Thirty-six healthy participants underwent near-infrared spectroscopy scanning while performing a top-down selective attentional DL task, a top-down divided attentional DL task, and a 2-back task. Pearson's correlations were calculated to show relationships between oxy-Hb concentration in each brain region and the score of each cognitive task. Different brain regions were activated during the DL and 2-back tasks. Brain regions activated in the top-down selective attention DL task were the left inferior prefrontal gyrus and left pars opercularis. The left temporopolar area was activated in the top-down divided attention DL task, and the left frontopolar area and left dorsolateral prefrontal cortex were activated in the 2-back task. As further evidence for the finding that each task measured different cognitive and brain area functions, neither the percentages of correct answers for the three tasks nor the response times for the selective attentional task and the divided attentional task were correlated to one another. Thus, the DL and 2-back tasks used in this study can assess multiple areas of cognitive, brain-related dysfunction to explore their relationship to different psychiatric and neurodevelopmental disorders.

    DOI

  • Foreword

    Kumano Hiroaki

    Anxiety Disorder Research   9 ( 1 ) 1 - 1  2017

    DOI CiNii

  • Updating of Autobiographical Memory about Heartbreaks during Memory Reconsolidation

    Tateishi Nanami, Nitta Yusuke, Takahashi Toru, Haitani Tomosumi, Kumano Hiroaki

    The Proceedings of the Annual Convention of the Japanese Psychological Association   81 ( 0 ) 2D - 055-2D-055  2017

    DOI CiNii

  • パーソナリティ障害における混同信念尺度の作成と信頼性・妥当性の検討

    樋沼友子, 富田 望, 金山裕介, 荒木美乃里, 黒田彩加, 熊野宏昭

    認知療法研究   10 ( 1 ) 65 - 74  2017  [Refereed]

  • 体型や食事に関するメタ認知的信念尺度の作成および信頼性と妥当性の検討

    長澤さやか, 熊谷真人, 富田 望, 木甲斐智紀, 熊野宏昭

    早稲田大学臨床心理学研究   17 ( 1 ) 59 - 68  2017  [Refereed]

  • Development of the Values Clarification Questionnaire and Confirmation of Its Reliability and Validity

    Saito Junichi, Yanagihara Mamika, Shima Taiki, Iwata Ayaka, Honda Hikari, Ohuchi Yuko, Kumano Hiroaki

    Japanese Journal of Behavior Therapy   43 ( 1 ) 15 - 26  2017

     View Summary

    <p>The purposes of the present study were to develop a questionnaire to measure the Acceptance and Commitment Therapy (ACT) core behavior processes of "Values" and "Committed Action" and to confirm the questionnaire's reliability and validity. In Study 1, exploratory factor analysis indicated that the new questionnaire had a 3-factor pattern: "Increased Motivation," "Continuing Behavior," and "Awareness of Reinforcement." Furthermore, Study 1 indicated that the questionnaire had adequate internal consistency and convergent and discriminant validity. Study 2 examined the questionnaire's construct validity, using structural equation modeling (SEM). The results revealed that as "Awareness of Reinforcement" and "Increased Motivation" increase, "Continuing Behavior" ensues; subjective well-being was enhanced and resulted in a decrease in experiential avoidance. In the future, the questionnaire's efficiency should be confirmed by conducting surveys with different participants, for instance, clinical patients, and a broader range of age groups and, subsequently, demonstrating its reliability and validity.</p>

    CiNii

  • Development of the Acceptance Process Questionnaire and Confirming Its Reliability and Validity

    Shima Taiki, Kawai Tomonori, Yanagihara Mamika, Ouchi Yuko, Saito Junichi, Iwata Ayaka, Honda Hikari, Kumano Hiroaki

    Japanese Journal of Behavior Therapy   43 ( 1 ) 1 - 13  2017

     View Summary

    <p>The present study aimed to develop a questionnaire to measure acceptance, a behavioral process that is emphasized in the third-wave cognitive and behavioral therapies, and to confirm its reliability and validity. Undergraduate and graduate students completed questionnaires. The results of a factor analysis indicated that the new 13-item questionnaire, the Acceptance Process Questionnaire (APQ), had a 4-factor pattern. The middle- or long-term results factors were "expanding behavioral repertoire" and "being receptive to the real world". The behavioral content factors were "making a choice not to avoid private events" and "stopping reactions". The questionnaire had adequate structural validity and internal consistency. Additionally, it is assumed that the Acceptance Process Questionnaire measures acceptance on the entire scale. However, more refinement is needed concerning convergent validity and test-retest reliability. Future research should aim to increase the workability of the questionnaire by confirming its test-retest reliability with a larger sample and by indicating the relation between questionnaire scores and behavioral tendencies in real-life.</p>

    CiNii

  • Relationships between Individual Social Capital and Mental Health in Elderly People who Left the Prefecture Due to the Fukushima Nuclear Power Plant Disaster

    Iwagaki Takahiro, Tsujiuchi Takuya, Masuda Kazutaka, Komaki Kumiko, Fukuda Chikako, Mochida Ryuhei, Ishikawa Noriko, Akano Yamato, Yamaguchi Maya, Inomata Tadashi, Negayama Koichi, Kojima Takaya, Kumano Hiroaki, Ogihara Atsushi

    Japanese Journal of Psychosomatic Medicine   57 ( 2 ) 173 - 184  2017

     View Summary

    <p>Background : As of March 2014, three years after the Fukushima nuclear power plant disaster, 58,624 residents were relocated to other regions within the Fukushima prefecture, and 47,683 residents were relocated to other prefectures. Attenuation of human relationships due to the disruption of regional ties nurtured in the past heightens stress. This highlights the need to create a new community focused on establishing ties with neighbors. Among evacuees, providing support for elderly adults suffering from a decline in physical functioning and a deteriorating mental health is necessary. Objective : This study investigated the relationship between individual social capital and mental health in elderly adults, specifically focusing on the role of social capital in reconstruction after the earthquake. Methods : A self-report questionnaire was conducted at Waseda University and Shinsai Shien Network, Saitama. Evacuees from Fukushima prefecture (n=3,599) who lived in Saitama prefecture and Tokyo were asked to complete the Stress Response Scale-18 comprising questions related to social capital with cognitive and structural indicators. There were 772 replies (response rate=21.5%) and 229 respondents were analyzed. In addition, a multiple logistic regression analysis was performed to examine the relationship between social capital and mental health in elderly adults. Results : The group with low confidence in neighbors relative to the group with high confidence in neighbors had a 5.192 times higher chance of being in the high-stress group (95%CI=1.042-25.865). In addition, the group with lower confidence in acquiring their neighbors assistance if a disaster occurred again, had a 2.172 times higher chance of being in the high-stress group (95%CI=1.051-4.487). Furthermore, people who have never participated in regional activities (e.g., hobbies, sports, entertainment, etc.) had a 3.112 times higher chance of being high-stressed relative to the group who participated two or three times (95%CI=1.059-9.150). Finally, the group that never greeted neighbors had a 3.317 times higher chance of being high-stressed relative to the group that had five or more greeted neighbors (95%CI=1.177-9.346). Conclusion : Lower social-capital cognitive indicators such as "trusting one's neighbors" and "helping one's neighbors" were correlated with higher stress levels. Therefore, elderly adults can presumably maintain good mental health by developing a neighborhood relationship and building mutual trust. Furthermore, lower social-capital structural indicators such as "number of greeted neighbors" and "participation frequency in regional activities" were correlated with higher stress levels. It is important to encourage social participation of evacuees and provide them with support.</p>

    DOI CiNii

  • 東日本大震災が生み出した自主的避難者における心的外傷後ストレス症状

    小牧 久見子, 持田 隆平, 岩垣 穂大, 石川 則子, 赤野 大和, 福田 千加子, 桂川 泰典, 増田 和高, 多賀 努, 小島 隆矢, 扇原 淳, 根ヶ山 光一, 熊野 宏昭, 辻内 琢也

    日本心療内科学会誌   20 ( 別冊 ) 109 - 109  2016.12

  • 回避行動が再固定化を利用した恐怖記憶のアップデートに及ぼす影響 想起後消去訓練による検討

    仁田 雄介, 高橋 徹, 灰谷 知純, 川島 一朔, 臼井 香, 鈴木 佑梨, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   42回   336 - 337  2016.10

  • 自然散策が子どもの気分・認知機能に及ぼす影響

    鈴木 佑梨, 佐々木 彩, 灰谷 知純, 川島 一朔, 臼井 香, 高橋 徹, 仁田 雄介, 熊野 宏昭

    日本認知・行動療法学会大会プログラム・抄録集   42回   394 - 395  2016.10

  • Development and evaluation of an electromagnetic hypersensitivity questionnaire for Japanese people

    Sachiko Hojo, Mikiko Tokiya, Masami Mizuki, Mikio Miyata, Kumiko T. Kanatani, Airi Takagi, Naomi Tsurikisawa, Setsuko Kame, Takahiko Katoh, Takuya Tsujiuchi, Hiroaki Kumano

    BIOELECTROMAGNETICS   37 ( 6 ) 353 - 372  2016.09  [Refereed]

     View Summary

    The purpose of the present study was to evaluate the validity and reliability of a Japanese version of an electromagnetic hypersensitivity (EHS) questionnaire, originally developed by Eltiti et al. in the United Kingdom. Using this Japanese EHS questionnaire, surveys were conducted on 1306 controls and 127 self-selected EHS subjects in Japan. Principal component analysis of controls revealed eight principal symptom groups, namely, nervous, skin-related, head-related, auditory and vestibular, musculoskeletal, allergy-related, sensory, and heart/chest-related. The reliability of the Japanese EHS questionnaire was confirmed by high to moderate intraclass correlation coefficients in a test-retest analysis, and high Cronbach's coefficients (0.853-0.953) from each subscale. A comparison of scores of each subscale between self-selected EHS subjects and age- and sex-matched controls using bivariate logistic regression analysis, Mann-Whitney U- and (2) tests, verified the validity of the questionnaire. This study demonstrated that the Japanese EHS questionnaire is reliable and valid, and can be used for surveillance of EHS individuals in Japan. Furthermore, based on multiple logistic regression and receiver operating characteristic analyses, we propose specific preliminary criteria for screening EHS individuals in Japan. Bioelectromagnetics. 37:353-372, 2016. (c) 2016 The Authors. Bioelectromagnetics Published by Wiley Periodicals, Inc.

    DOI PubMed

  • 東日本大震災4年目の宮城県被災者の外傷後ストレス症状に影響をあたえる身体・心理・社会的要因

    高橋 光咲, 辻内 琢也, 岩垣 穂大, 増田 和高, 扇原 淳, 熊野 宏昭

    心身医学   56 ( 6 ) 676 - 676  2016.06

  • 東日本大震災4年目の岩手県被災者の外傷後ストレス症状に影響をあたえる身体・心理・社会的要因

    川崎 拓真, 小牧 久見子, 岩垣 穂大, 赤野 大和, 高橋 光咲, 福田 千加子, 増田 和高, 扇原 淳, 熊野 宏昭, 辻内 琢也

    心身医学   56 ( 6 ) 677 - 677  2016.06

  • 原子力発電所事故4年後の被災者の放射線・放射能のイメージとストレス度との関連

    小牧 久見子, 岩垣 穂大, 赤野 大和, 川崎 拓真, 高橋 光咲, 福田 千加子, 増田 和高, 扇原 淳, 熊野 宏昭, 辻内 琢也

    心身医学   56 ( 6 ) 677 - 677  2016.06

  • QEESI問診票およびEHS問診票を用いた調査(その1) 化学物質過敏症専門医による症状経過からの患者のタイプ分類

    北條 祥子, 水越 厚史, 水城 まさみ, 宮田 幹夫, 大友 守, 小倉 英郎, 坂部 貢, 東 賢一, 奥村 二郎, 角田 和彦, 乳井 美和子, 熊野 宏昭

    日本臨床環境医学会総会プログラム・抄録集   25回   37 - 37  2016.06

  • QEESI問診票およびEHS問診票を用いた調査(その2) 化学物質過敏症患者、喘息患者、自己申告電磁過敏症有訴者、および一般人の症状・反応の比較

    水越 厚史, 水城 まさみ, 宮田 幹夫, 大友 守, 小倉 英郎, 釣木澤 尚実, 押方 智也子, 熊野 宏昭, 坂部 貢, 青木 真一, 東 賢一, 奥村 二郎, 金谷 久美子, 今井 奈妙, 宮田 英威, 北條 祥子

    日本臨床環境医学会総会プログラム・抄録集   25回   38 - 38  2016.06

  • High Prevalence of Post-Traumatic Stress Symptoms in Relation to Social Factors in Affected Population One Year after the Fukushima Nuclear Disaster

    Takuya Tsujiuchi, Maya Yamaguchi, Kazutaka Masuda, Marisa Tsuchida, Tadashi Inomata, Hiroaki Kumano, Yasushi Kikuchi, Eugene F. Augusterfer, Richard F. Mollica

    PLOS ONE   11 ( 3 )  2016.03  [Refereed]

     View Summary

    Objective
    This study investigated post-traumatic stress symptoms in relation to the population affected by the Fukushima Nuclear Disaster, one year after the disaster. Additionally, we investigated social factors, such as forced displacement, which we hypothesize contributed to the high prevalence of post-traumatic stress. Finally, we report of written narratives that were collected from the impacted population.
    Design and Settings
    Using the Impact of Event Scale-Revised (IES-R), questionnaires were sent to 2,011 households of those displaced from Fukushima prefecture living temporarily in Saitama prefecture. Of the 490 replies; 350 met the criteria for inclusion in the study. Multiple logistic regression analysis was performed to examine several characteristics and variables of social factors as predictors of probable post-traumatic stress disorder, PTSD.
    Results
    The mean score of IES-R was 36.15 +/- 21.55, with 59.4% having scores of 30 or higher, thus indicating a probable PTSD. No significant differences in percentages of high-risk subjects were found among sex, age, evacuation area, housing damages, tsunami affected, family split-up, and acquaintance support. By the result of multiple logistic regression analysis, the significant predictors of probable PTSD were chronic physical diseases (OR = 1.97), chronic mental diseases (OR = 6.25), worries about livelihood (OR = 2.27), lost jobs (OR = 1.71), lost social ties (OR = 2.27), and concerns about compensation (OR = 3.74).
    Conclusion
    Although there are limitations in assuming a diagnosis of PTSD based on self-report IES-R, our findings indicate that there was a high-risk of PTSD strongly related to the nuclear disaster and its consequent evacuation and displacement. Therefore, recovery efforts must focus not only on medical and psychological treatment alone, but also on social and economic issues related to the displacement, as well.

    DOI

  • マインドフルネス系CBTの理論と方法論

    熊野宏昭, 富田 望, 嶋 大樹, 川島一朔

    臨床心理学   16 ( 4 ) 439 - 443  2016

  • 慢性疾患患者の生活指導からQOLの拡大へ―認知行動療法による支援―

    嶋 大樹, 富田 望, 熊野宏昭

    Journal of Clinical Rehabilitation   25   1083 - 1087  2016

  • 注意訓練法を用いた全般性不安障害患者に対するメタ認知療法

    黒田彩加, 岩田彩香, 齋藤順一, 富田 望, 熊野宏昭

    早稲田大学臨床心理学研究   16 ( 1 ) 3 - 17  2016  [Refereed]

  • 脅威モニタリング尺度の作成および信頼性・妥当性の検討

    熊谷真人, 荒木美乃里, 富田 望, 黒田彩加, 樋沼友子, 熊野宏昭

    早稲田大学臨床心理学研究   16 ( 1 ) 55 - 64  2016  [Refereed]

  • Social Factors Affecting Psychological Stress of the Evacuees Out of Fukushima Prefecture by the Cause of Nuclear Accident after the Great East Japan Earthquake

    Yamaguchi Maya, Tsujiuchi Takuya, Masuda Kazutaka, Iwagaki Takahiro, Ishikawa Noriko, Fukuda Chikako, Hirata Shuzo, Inomata Tadashi, Negayama Koichi, Kojima Takaya, Ogihara Atsushi, Kumano Hiroaki

    Japanese Journal of Psychosomatic Medicine   56 ( 8 ) 819 - 832  2016

     View Summary

    <p>Backgrounds : This study reports the results of a questionnaire survey conducted in the households consisting of inhabitants of Fukushima Prefecture who have evacuated to Saitama Prefecture or Tokyo Metropolis at one and two years after the Great East Japan Earthquake. The Great East Japan Earthquake in 2011 has been expanded to the nuclear power plant disaster. Consequently, approximately 56,920 inhabitants of Fukushima evacuated to other prefectures as of March 2013. This consequence sets the 2011 earthquake apart from previous natural disasters. Method : This survey was conducted by "Earthquake and human sciences project" of Waseda University and Shinsai Shien Network Saitama. Psychological stress of the evacuees (2,011 households in 2012 ; 1,875 households in Saitama and 2,393 households in Tokyo in 2013) were examined one year and two years after the disaster respectively. The questionnaire also contained such items as severity of housing destruction, Tsunami affection, worries about livelihood sustainability etc. In this study, psychological stress was measured using the Stress Response Scale-18 (SRS-18). Results : The results revealed that the stress reaction level of the evacuees from Fukushima Prefecture living in other prefectures is still "somewhat higher" despite two years passed since the disaster. A chi-square test was used to determine psychosocial factors influencing stress reactions. Results of the survey in 2012 revealed that anxiety about living costs or joblessness influenced stress reactions in men, whereas damaged houses, personal relationships, and compensation problems related to the nuclear power plant influenced stress reactions in women. However, according to the results of the 2013 survey, difficult economic conditions, aggravated health conditions, negative labeling as an evacuee, and dissatisfaction with relationships with family and neighbors influenced stress reactions in both men and women. Conclusion : The results revealed that the psychological stress is strongly related to several social factors ; economic conditions, health status, family and community relationships, and dwelling environments. By the comparison between first year result and second year result, the causes of stressors have been changed from the damage of earthquake disaster itself into the circumstances of shelter life over time. Therefore, the work in cooperation among medicine, clinical psychology, social welfare, and legal support is necessary in order to obtain mental health recovery.</p>

    DOI CiNii

  • Updating of Fear Memories by Behavioral Interventions during Memory Reconsolidation

    Nitta Yusuke, Takahashi Toru, Kumano Hiroaki

    Anxiety Disorder Research   8 ( 1 ) 58 - 66  2016

     View Summary

    <p>Extinction training establishes extinction learning and, thus, inhibits conditioned fear responses. However, fear responses may return because extinction learning cannot affect memory trace that is the origin of fear. Exposure therapy, which is based on the extinction learning paradigm, is used to treat anxiety disorders. Relapses of anxiety disorders after exposure therapy have also been reported. Consequently, treatments, which can prevent the return of fear responses, are needed. Recently, a mechanism known as memory reconsolidation has been receiving much attention. Consolidated memory traces are destabilized after they have been retrieved. Those memory traces are stabilized again by means of the reconsolidation process. During reconsolidation, retrieved fear memory can be updated. Furthermore, recent studies have shown that extinction training during reconsolidation updates fear memory and prevents the return of fear responses. Further studies are required to determine the effects of reconsolidation interventions on anxiety disorders.</p>

    DOI CiNii

  • Relation between Post-Event Processing (PEP) and Attentional Control Functions: With Developing the Functional Recall Vantage Perspective Scale during PEP

    Tomita Nozomi, Imai Shoji, Yamaguchi Maya, Kumano Hiroaki

    Anxiety Disorder Research   8 ( 1 ) 12 - 21  2016

     View Summary

    <p>Post-Event Processing (PEP) is defined that ruminating about anxiety-evoking social events; it is a key factor contributing to social anxiety. Although previous studies have shown that rumination and worry similar to PEP in terms of repetitive thinking style are related to attentional control functions, the relevance of PEP and attentional control functions has not been clarified. Moreover, no instrument has been developed to measure the observer's perspective during PEP. We investigated the relation between the PEP of an experimental social situation and attentional control functions with developing the Functional Recall Vantage Perspective Scale during PEP. Undergraduate students completed several questionnaires and a cognitive task measuring their attentional control functions. They then participated in a speech task. The following day, we measured the PEP of the speech task and conducted a correlation analysis between the PEP scores and the attentional control function scores. The results indicated that the Observer–Avoidance perspective subscale of the Functional Recall Vantage Perspective Scale can measure the observer's perspective of PEP. Furthermore, they also showed that negative PEP and the Observer–Avoidance perspective are negatively correlated with selective attentional control functions. Therefore, to decrease PEP in particular, focusing on selective attention may be beneficial.</p>

    CiNii

  • High-level Post-traumatic Stress Symptoms of the Residents in Fukushima Temporary Housing : Bio-psycho-social Impacts by Nuclear Power Plant Disaster

    Tsujiuchi Takuya, Komaki Kumiko, Iwagaki Takahiro, Masuda Kazutaka, Yamaguchi Maya, Fukuda Chikako, Ishikawa Noriko, Mochida Ryuhei, Kojima Takaya, Negayama Koichi, Ogihara Atsushi, Kumano Hiroaki

    Japanese Journal of Psychosomatic Medicine   56 ( 7 ) 723 - 736  2016

     View Summary

    Backgrounds : Fukushima nuclear power plant disaster occurred following the Great East Japan Earthquake on March 11, 2011. It bears comparison with the incident in Chernobyl in 1986 in the degree of radiological contamination to the surrounding environment. 164,218 residents were displaced losing their home-land by this serious incident, of which 97,321 were relocated to other regions within the Fukushima prefecture, and 57,135 residents were relocated to other prefectures. The evacuees from Fukushima can be considered the largest number of 'internally displaced persons' or 'domestic refugees' in Japan after the world war two. Objective : This study investigated the scale of post-traumatic stress (PTS) symptoms in the evacuees as of two years after the Fukushima nuclear power plant disaster. It also tried to identify the impact of bio-psycho-social factors related to PTS symptoms. Samples and methods : Questionnaire survey was conducted by Waseda University and Japan Broadcasting Corporation (NHK). 2,425 households living at temporary housings within Fukushima prefecture were asked to answer the Impact of Event Scale-Revised (IES-R) and the self-report questionnaires that we generated in order to evaluate the damage by the disaster in relation to several bio-psycho-social factors in refugee lives. There were 745 replies (the cooperation rate ; 30.7%), of which 661 were analyzed. Besides, multiple logistic regression analysis was performed to examine several bio-psycho-social factors as predictors for probable PTSD. Results : High level PTS symptoms were found. The mean score of IES-R was 34.20±20.56, and 62.56% were over 24/25 cut-off point determined as broadly defined PTSD which means high-risk presence of probable PTSD. The significant differences by chi-square test of high-risk subjects were found among economic difficulty (p=.000), concerns about compensation (p=.000), lost jobs (p=.023), unsatisfying housing (p=.025), unsatisfying environment around temporary housing (p=.000), having chronic disease (p=.003), aggravation of chronic disease (p=.000), affection of new disease (p=.000), lack of necessary information (p=.000), family split-up (p=.031), and lack of acquaintance support (p=.000). By the result of multiple logistic regression analysis, the significant predictors of probable PTSD were economic difficulty (OR : 2.34, 95%CI : 1.30-4.24), concerns about compensation (OR : 4.16, 95%CI 1.26-13.76), aggravation of chronic disease (OR : 2.94, 95%CI : 1.63-5.30), affection of new disease (OR : 2.20, 95%CI : 1.21-3.99), and lack of acquaintance support (OR : 1.92, 95%CI : 1.07-3.42). Conclusion : The findings revealed that there is a high-risk presence of probable PTSD strongly related to a number of bio-psycho-social factors due to the nuclear power plant disaster and its consequent evacuation. Our findings underscore the specific characteristics of the nuclear disaster as man-made disaster. Since the socio-economic problems such as compensation and reparation have not been solved, it is suggested that prolonged uncertainty regarding the insufficient salvation of the evacuees might account for the high-level PTS symptoms.

    CiNii

  • The relationship between attentional function and stuttering severity in adults who stutter

    Tomosumi Haitani, Hiroaki Kumano

    Japan Journal of Logopedics and Phoniatrics   57 ( 2 ) 217 - 226  2016

     View Summary

    Recently, it has been demonstrated that children who stutter (CWS) have attentional difficulties. But little is known about attentional function in adults who stutter (AWS). Two groups of 17 AWS and 18 adults who do not stutter (AWNS) participated in the present study. We aimed to confirm (1) whether AWS also show attentional difficulties like CWS and (2) how attentional function relates to stuttering severity in AWS. Results indicated that AWS and AWNS showed similar levels of attentional function, but those who tended to react faster and more incorrectly to the experimental task showed worse stuttering severity. This outcome suggests that cognitive strategies non-specific to speech production can influence stuttering severity. We discussed intervention for the attentional function in AWS.

    DOI CiNii

  • 社交不安者における特性不安および抑うつ症状と注意制御機能, 解釈バイアスの関連.

    富田 望, 西 優子, 今井正司, 熊野宏昭

    認知療法研究   9 ( 1 ) 44 - 54  2016

  • 瞑想経験者における注意訓練中のEEG信号源推定の試み.

    川島一朔, 灰谷知純, 杉山風輝子, 臼井香, 井上ウィマラ, 熊野宏昭

    マインドフルネス研究   1 ( 1 ) 3 - 6  2016

  • The relationship between attentional function and stuttering severity in adults who stutter

    Tomosumi Haitani, Hiroaki Kumano

    Japan Journal of Logopedics and Phoniatrics   57 ( 2 ) 217 - 226  2016

     View Summary

    Recently, it has been demonstrated that children who stutter (CWS) have attentional difficulties. But little is known about attentional function in adults who stutter (AWS). Two groups of 17 AWS and 18 adults who do not stutter (AWNS) participated in the present study. We aimed to confirm (1) whether AWS also show attentional difficulties like CWS and (2) how attentional function relates to stuttering severity in AWS. Results indicated that AWS and AWNS showed similar levels of attentional function, but those who tended to react faster and more incorrectly to the experimental task showed worse stuttering severity. This outcome suggests that cognitive strategies non-specific to speech production can influence stuttering severity. We discussed intervention for the attentional function in AWS.

    DOI

  • Validation of the Japanese Version of the Cognitive Fusion Questionnaire : The 13-Item Content Revised Version and the 7-Item Version

    SHIMA Taiki, KAWAI Tomonori, YANAGIHARA Mamika, KUMANO Hiroaki

    Japanese Journal of Behavior Therapy   42 ( 1 ) 73 - 83  2016

     View Summary

    This study investigated the validation of the Japanese version of the 13-item Cognitive Fusion Questionnaire (CFQ) whose content was revised and the 7-item CFQ. Results of a survey of university students showed that the revised CFQ-13 reflects a two-factor structure, whereas the CFQ-7 reflects a one-factor structure similar to the previous study. Results of item analysis showed that treating each factor independently is appropriate. It was previously assumed that the two structures corresponded to "cognitive fusion" (Factor I) and "cognitive defusion" getting out of cognitive fusion (Factor II), respectively. However, results showed that Factor II corresponds to "a component of the function of defusion." Therefore, Factor I or the CFQ-7 is equivalent to cognitive fusion, and Factor II is appropriate to measure a part of defusion that is "the discrimination of self and thought." Moreover, the CFQ-13 requires an additional and different validation strategy by investigating the relationship with overt behavioral measurements in future studies.

    DOI CiNii

  • 福島原子力発電所事故による自主的避難者のストレス 現居住地の放射線に対する安心感に着目して

    小牧 久見子, 岩垣 穂大, 持田 隆平, 赤野 大和, 福田 千加子, 石川 則子, 桂川 泰典, 増田 和高, 多賀 努, 小島 隆矢, 熊野 宏昭, 扇原 淳, 根ヶ山 光一, 辻内 琢也

    日本心療内科学会誌   19 ( 別冊 ) 93 - 93  2015.11

  • 福島原子力発電所事故による母子避難者のストレス 家族関係とソーシャルキャピタルに着目して

    岩垣 穂大, 小牧 久見子, 赤野 大和, 福田 千加子, 持田 隆平, 石川 則子, 桂川 泰典, 増田 和高, 多賀 努, 小島 隆矢, 根ヶ山 光一, 熊野 宏昭, 扇原 淳, 辻内 琢也

    日本心療内科学会誌   19 ( 別冊 ) 94 - 94  2015.11

  • 化学物質過敏症患者と喘息患者の微量化学物質や電磁場曝露による過敏反応

    北條 祥子, 釣木澤 尚美, 水城 まさみ, 坂部 貢, 宮田 幹夫, 小倉 英郎, 大友 守, 押方 智也子, 須藤 京子, 山口 拓洋, 辻内 琢也, 熊野 宏昭

    Journal of Environmental Dermatology and Cutaneous Allergology   9 ( 5 ) 475 - 475  2015.11

  • In-situ real-time monitoring of volatile organic compound exposure and heart rate variability for patients with multiple chemical sensitivity

    Atsushi Mizukoshi, Kazukiyo Kumagai, Naomichi Yamamoto, Miyuki Noguchi, Kazuhiro Yoshiuchi, Hiroaki Kumano, Kou Sakabe, Yukio Yanagisawa

    International Journal of Environmental Research and Public Health   12 ( 10 ) 12446 - 12465  2015.10

     View Summary

    In-situ real-time monitoring of volatile organic compound (VOC) exposure and heart rate variability (HRV) were conducted for eight multiple chemical sensitivity (MCS) patients using a VOC monitor, a Holter monitor, and a time-activity questionnaire for 24 h to identify the relationship between VOC exposure, biological effects, and subjective symptoms in actual life. The results revealed no significantly different parameters for averaged values such as VOC concentration, HF (high frequency), and LF (low frequency) to HF ratio compared with previous data from healthy subjects (Int. J. Environ. Res. Public Health 2010, 7, 4127–4138). Significant negative correlations for four subjects were observed between HF and amounts of VOC change. These results suggest that some patients show inhibition of parasympathetic activities along with VOC exposure as observed in healthy subjects. Comparing the parameters during subjective symptoms and normal condition, VOC concentration and/or VOC change were high except for one subject. HF values were low for five subjects during subjective symptoms. Examining the time-series data for VOC exposure and HF of each subject showed that the subjective symptoms, VOC exposure, and HF seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed.

    DOI PubMed

  • The effects of attention training on mind wandering, depression and anxiety

    Usui Kaori, Kawashima Issaku, Haitani Tomosumi, Sugiyama Hukiko, Sasaki Aya, Takahashi Toru, Kumano Hiroaki

    The Proceedings of the Annual Convention of the Japanese Psychological Association   79   3EV - 052-3EV-052  2015

    DOI CiNii

  • 注意訓練がマインドワンダリング及び抑うつ・不安へ及ぼす影響

    臼井 香, 川島一朔, 灰谷知純, 杉山風輝子, 富田 望, 佐々木彩, 高橋 徹, 熊野宏昭

    早稲田大学臨床心理学研究   15 ( 1 ) 91 - 99  2015  [Refereed]

  • メタ認知的観点から見た抑うつ症状と心配の関連性の検討

    黒田彩加, 友惠眞理子, 富田 望, 岸野有里, 荒木美乃里, 樋沼友子, 熊野宏昭

    早稲田大学臨床心理学研究   15 ( 1 ) 65 - 72  2015  [Refereed]

  • 注意訓練法が注意機能及びメタ認知的信念・ネガティブ感情に与える影響

    佐々木彩, 灰谷知純, 富田 望, 越川房子, 熊野宏昭

    早稲田大学臨床心理学研究   14 ( 1 ) 99 - 108  2015  [Refereed]

  • 全般性不安障害のメタ認知モデルと思考制御の必要性に関する信念の関連

    岸野有里, 富田 望, 熊野宏昭

    早稲田大学臨床心理学研究   14 ( 1 ) 79 - 87  2015  [Refereed]

  • 社交不安におけるPost-event processingと注意制御機能の関連

    富田 望, 西 優子, 今井正司, 熊野宏昭

    早稲田大学臨床心理学研究   14 ( 1 ) 47 - 55  2015  [Refereed]

  • Development of The Coping Assessment Questionnaire during depressive mood (CAQ-D) : examination of validity

    Shinoura Tomoki, Shima Taiki, Kumano Hiroaki, Sakai Motohiro

      23   57 - 67  2015

     View Summary

    The purpose of this study was to examine variations of coping during depressive moods in terms of behavioral activation and the relationship between patterns of coping and severity of depression.First, we collected items of coping during depressive moods by interviewing 29 undergraduate students. Then, based on the data the COPING ASSESSMENT QUESTIONNAIRE during depressive moods (CAQ-D) was developed. To investigate the factor structure of CAQ-D, CAQ-D was completed by 209 undergraduates. The results of a factor analysis indicated that CAQ-D consisted of three factors: (a)Activation , (b)Observing One's Experience , and (c)Distraction. Activation was positively related to Behavioral Activation for Depression Scale(BADS), and Observing One's Experience was positively correlated with Observing (Five Facet Mindfulness Questionnaire; FFMQ). However, Distraction showed no correlation with the Acceptance and Action Questionnaire-II(AAQ-II).Secondly, we defined coping style against depressive mood based on the CAQ-D, and investigated the relationship between coping styles and depression. The results showed that there were 4 coping styles : (a)all high Coping group, (b)high Activation and Distraction group, (c)Distraction group, and (d)Activation and Observing One's Experience group. Moreover, the high Activation and Distraction group felt more positive feelings than Distraction group. Although no consideration was placed on the relation between coping styles and stressors, these results suggest that one who has many variations of coping can gain more positive reinforcements.

    CiNii

  • 行動療法・認知行動療法の現在と未来(一般公開シンポジウム)

    神村 栄一, 五十嵐 透子, 若島 孔文, 鶴 光代, 熊野 宏昭, 井上 雅彦

    日本認知・行動療法学会大会プログラム・抄録集   ( 41 )  2015

    CiNii

  • 能動的注意制御における主観的側面と抑うつ及び不安との関連.

    今井正司, 熊野宏昭, 今井千鶴子, 根建金男

    認知療法研究   8 ( 1 ) 85 - 95  2015

  • 呼吸に気づきを向ける短期間のマインドフルネスのエクササイズが吃音者の苦手場面に与える影響.

    灰谷知純, 佐々木淳, 熊野宏昭

    コミュニケーション障害学   32 ( 1 ) 20 - 26  2015

  • Dysfunction of ventrolateral prefrontal cortex underlying social anxiety disorder: A multi-channel NIRS study

    Chika Yokoyama, Hisanobu Kaiya, Hiroaki Kumano, Masaru Kinou, Tadashi Umekage, Shin Yasuda, Kunio Takei, Masami Nishikawa, Tsukasa Sasaki, Yukika Nishimura, Naomi Hara, Ken Inoue, Yui Kaneko, Shin-ichi Suzuki, Hisashi Tanii, Motohiro Okada, Yuji Okazaki

    NEUROIMAGE-CLINICAL   8   455 - 461  2015  [Refereed]

     View Summary

    Social anxiety disorder (SAD) is characterized by strong fear and anxiety during social interactions. Although ventrolateral prefrontal cortex (VLPFC) activity in response to emotional stimuli is related to pathological anxiety, little is known about the relationship between VLPFC activity and social anxiety. This study aimed to investigate whether VLPFC activity was involved in SAD and whether VLPFC activity was related to the level of social anxiety. Twenty-four drug-naive patients with SAD and 35 healthy controls underwent near-infrared spectroscopy (NIRS) scanning while performing a verbal fluency task (VFT). Results indicated that, compared to the healthy controls, the SAD patients exhibited smaller changes of oxygenated hemoglobin (oxy-Hb) concentrations in the VLPFC during the VFT. Furthermore, the right VLPFC activation was negatively correlated with social avoidance. In contrast to the latter, the healthy controls exhibited a positive correlation between changes of oxy-Hb concentrations in the bilateral VLPFC and social fear. Our findings provide evidence for VLPFC dysfunction in SAD, and indicate that the VLPFC dysfunction may contribute to the difference between normal and abnormal social anxiety. (C) 2015 The Authors. Published by Elsevier Inc.

    DOI

  • Development of the Three Senses of the Selves Questionnaire and Confirmation of Its Reliability and Validity

    YANAGIHARA Mamika, SHIMA Taiki, SAITO Junichi, KAWAI Tomonori, KUMANO Hiroaki

    Japanese Journal of Behavior Therapy   41 ( 3 ) 225 - 238  2015

     View Summary

    The present study aimed to develop a Three Senses of the Selves Questionnaire (TSSQ) and confirm its reliability and validity. Furthermore, the functions involved in the 3 selves were examined in order to identify more appropriate behavior classes (sets of behaviors with similar functions) than the 3 conventional behavioral processes. A new questionnaire, comprised of 33 items, was completed by college students. Exploratory factor analysis indicated that the Three Senses of the Selves Questionnaire had a 4-factor pattern: "acting actively and flexibly in the world," "conceptualized self," "distancing from private events," and "feeling the present moment." Additional structural equation modeling indicated that the 3 selves had 2 valid behavioral classes. Cronbach's α for all the factors was sufficiently high (α=.72-.83), and the questionnaire met the standards for content and convergent validity. Future studies should examine the relations between the 3 selves and other behavioral processes relevant to Acceptance and Commitment Therapy (ACT) and various clinical symptoms, and develop an understanding of how these senses of the 3 selves aggravate or assuage mental pain.

    DOI CiNii

  • 日本における電磁過敏症(EHS)患者の実態調査の開始

    北條 祥子, 秋山 一男, 水城 まさみ, 小倉 英郎, 宮田 幹夫, 石川 哲, 坂部 貢, 釣木澤 尚実, 押方 智也子, 長谷川 眞紀, 大友 守, 今井 奈妙, 土器屋 美貴子, 乳井 美和子, 角田 和彦, 木俣 肇, 加藤 貴彦, 五十嵐 公英, 井上 博之, 青木 真一, 高塚 俊治, 近藤 加代子, 吉富 邦明, 水越 厚史, 辻内 琢也, 宮田 英威, 熊野 宏昭

    日本臨床環境医学会総会プログラム・抄録集   23回   77 - 77  2014.05

  • アレルギー疾患、シックハウス症候群、化学物質過敏症、電磁過敏症の相互関係 QEESI問診票を用いた症状、化学物質不耐性、日常生活障害の比較

    北條 祥子, 秋山 一男, 水城 まさみ, 宮田 幹夫, 石川 哲, 坂部 貢, 相澤 好治, 小倉 英郎, 山中 隆夫, 角田 和彦, 吉野 博, 釣木澤 尚実, 長谷川 眞紀, 大友 守, 押方 智也子, 水越 厚史, 今井 奈妙, 加藤 貴彦, 木俣 肇, 辻内 琢也, 熊野 宏昭

    日本臨床環境医学会総会プログラム・抄録集   23回   78 - 78  2014.05

  • Body Image Dissatisfaction and Subjective Way of Viewing the Whole Body in a Mirror

    Sugiyama Fukiko, Kiire Mio, Imai Shoji, Kumano Hiroaki

    Japanese Journal of Psychosomatic Medicine   54 ( 3 ) 266 - 273  2014.03

     View Summary

    Background : Body image dissatisfaction (BID) tendency is a diagnostic item for an eating disorder (ED) and body checking (BC) is a behavioral feature of ED. A relationship between BID and BC has been hypothesized. It has been reported that mirror exposure (ME) is an effective intervention method for improving BID and BC. In ME, the client looks at the whole body in a mirror for about 1〜2 minutes, doing as little evaluation as possible. However, the precise relationship between BID and BC has not been shown and the cognitive processing style during ME has not been clarified. The purpose of this research was to clarify the relationship between BID and BC by using questionnaire survey, and to experimentally examine the subjective way of viewing the whole body in a mirror based on the differences in BID tendency. Method : Participants were female college students (n=382 : mean age 20.0 years, SD=1.69) attending the Waseda University, in Tokyo, Japan. Participants responded to the following questionnaires : (1) Eating Attitude Test-26 Japanese version (EAT-26), (2) Body Image Dissatisfaction measure (BID measure), and (3) Body Checking Cognitions Scale Japanese version (BCCS). Seven participants (Mean age 21.7 years, SD=5.02) who consented to the participation in an experiment were divided into two groups based on their BID measure ; namely those with an average score of 59.1, +0.5 SD were included in the high BID group (H group) and the others in the normal BID group (N group). In the experiment, participants were asked to freely look at their whole body in a mirror for 5 minutes. After that, the participants responded to a questionnaire inquiring about their feelings when looking at the mirror, as well as their usual feelings about their body. Results : In EAT-26, BID measure, and BCCS, a moderate significant positive correlation was shown, respectively (r=0.412〜0.538, p<0.01). Moreover, a weak but significant positive correlation was shown in the partial correlation of BID measure and BCCS, after controlling EAT-26 score (r=0.253, p<0.01). When the numbers of body parts that H and N groups intentionally looked at were compared using a Wilcoxon rank sum correlation test, H group inclined to look at larger numbers of body parts than N group did (p=0.0692). Similarly, H group showed a significantly larger difference represented by the absolute value between the degree of usual negative feelings about the most disliked body part and negative feelings when looking at it in a mirror than N group did (p=0.0498). Considerations : The study indicated a relationship between BID and BC regardless of ED tendency. Moreover, people with strong BID experienced different feelings when they usually think of their body and when they look at their body in a mirror. It is suggested that this could be because they avoid looking at the parts of their body resulting in negative feelings in their daily life when looking in a mirror. Conclusion This study indicated a relationship between ED and BID and BC, and a possibility that people with strong BID avoid looking at the parts of their body. Therefore, it is expected that presenting ME to people with strong BID will stop avoiding their body image and improve body image overestimation (/underestimation).

    CiNii

  • The Cognitive Behavioral Treatments for Panic Disorder

    Kumano Hiroaki

    Anxiety Disord Res   6 ( 1 ) 34 - 42  2014

     View Summary

    The cognitive behavioral treatments for panic disorder and agoraphobia are the most representative evidence-based psychotherapies for psychiatric disorders, and many treatment studies and meta-analyses have been conducted. Exposure and behavioral experiments, relaxation and breathing re-training, psycho-education and cognitive intervention, and homework assignment are included in most of the empirically-supported treatment programs for panic disorders, and a recent meta-analysis indicated that exposure and relaxation are the most effective treatment components. It was assumed to be necessary for the evoked fear and anxiety to be reduced thoroughly through long enough exposure in order to extinguish fear conditioning, but many recent studies showed that the newly associative inhibitory learning is indispensable for the extinction. The reduction of fear in an exposure trial is not mandatory for the inhibition learning to be promoted, but fully experiencing feared symptoms and sensations without safety behaviors and recognizing that negative consequences do not pursue are vital. The role of acceptance during exposure has attracted much attention for those purposes.

    DOI CiNii

  • 社交不安傾向者における注意制御機能と解釈バイアスの関連

    富田 望, 西 優子, 今井正司, 熊野宏昭

    早稲田大学臨床心理学研究   13 ( 1 ) 33 - 41  2014  [Refereed]

  • 中学生における注意制御機能,ディタッチト・マインドフルネス,反芻,メタ認知的信念が抑うつに及ぼす影響

    西優子, 今井正司, 金山裕介, 熊野宏昭

    認知療法研究   7 ( 1 ) 55 - 65  2014

  • 複雑性悲嘆の予防に向けた介入の一例—第三世代の認知行動療法を援用した介入—.

    高橋恵理子, 岡山紀子, 千葉宏明, 熊野宏昭

    カウンセリング研究   47 ( 1 ) 20 - 29  2014

  • 怒り反潟に対するメタ認知的信念尺度の作成及び信頼性ど妥当性の検討.

    金ヌルプルンソル, 山口摩弥, 今井正司, 熊野宏昭, 野村忍

    認知療法研究   7 ( 2 ) 180 - 188  2014

  • 性にまつわる強迫観念に対する行動処方(口頭発表,行動療法コロキウム'12 in 信州美ヶ原開催報告,コロキウム報告)

    岡嶋 美代, 熊野 宏昭

    行動療法研究   39 ( 3 ) 173 - 174  2013.09

    CiNii

  • 高所恐怖傾向における言語刺激間の関係反応と回避行動の関係

    川井智理, 宇留鷲美紀, 久保絢子, 嶋田洋徳, 熊野宏昭

    臨床心理学研究(早稲田大学人間科学学術院心理相談室)   12 ( 1 ) 29 - 37  2013

  • The One-Month Survey about Individual Cognitive Behavior Therapy for Anxiety Disorders to Apply for the National Health Insurance Scheme in Japan

    Shimizu Eiji, Sasaki Tsukasa, Kumano Hiroaki, Kaiya Hisanobu, Kuboki Tomifusa

    Anxiety Disord Res   4 ( 1 ) 44 - 59  2013

    CiNii

  • Mindfulness-Based Psychotherapyを効果的に実践するために(自主企画シンポジウム3,テーマ:認知行動療法の「今」)

    伊藤 義徳, 熊野 宏昭, 上田 幸彦, 石井 朝子, 宇留鷲 美紀

    日本行動療法学会大会発表論文集   ( 38 ) 78 - 79  2012.09

    CiNii

  • 行動療法研究への手紙 : 原井論文を読んで、行動療法について考える : 原井(2012)へのリプライ(編集委員会への手紙)

    高橋 史, 大塚 明子, 熊野 宏昭

    行動療法研究   38 ( 3 ) 259 - 260  2012.09

    CiNii

  • Effects of Cognitive Behavioral Group Therapy on Adults with Depression : A Controlled Clinical Trial(<Special Issue>Effectiveness of Cognitive Behavior Therapy for Depression Provided by Psychologists in Japan)

    ITO Daisuke, KANEKO Yui, SUYAMA Haruna, KANAYA Toshihiro, TANOUE Asuka, KOSEKI Shunsuke, KAIYA Hisanobu, KUMANO Hiroaki, SUZUKI Shin-ichi

    Japanese journal of behavior therapy   38 ( 3 ) 169 - 179  2012.09

     View Summary

    The present article reports effects of cognitive behavioral group therapy (CBGT) on adults with depression, using a controlled clinical trial. The cognitive behavioral group therapy consisted of 12 sessions developed by psychologists, consisting of Beck's cognitive therapy and problemsolving therapy. Participants (n=10) received this treatment from a psychologist, including pharmacotherapy (treatment as usual; TAU) combined with the cognitive behavioral group therapy program (TAU+CBGT group). The other participants (n=10) received only pharmacotherapy (TAU group). The Beck Depression Inventory-II (BDI-II) which measures depression was completed by the participants at 3 times (pre-, mid-, and post) during the cognitive behavioral group therapy program. The results revealed that after the therapy, depression in the group receiving cognitive behavioral therapy with pharmacotherapy improved significantly more than in the treatment-as-usual group. These results suggest that for adults with depression, the administration of pharmacotherapy combined with cognitive behavioral group therapy managed by a psychologist may be more effective than treatment with pharmacotherapy only.

    CiNii

  • EEG source imaging during two Qigong meditations.

    Pascal L Faber, Dietrich Lehmann, Shisei Tei, Takuya Tsujiuchi, Hiroaki Kumano, Roberto D Pascual-Marqui, Kieko Kochi

    Cognitive processing   13 ( 3 ) 255 - 65  2012.08  [Refereed]  [International journal]

     View Summary

    Experienced Qigong meditators who regularly perform the exercises "Thinking of Nothing" and "Qigong" were studied with multichannel EEG source imaging during their meditations. The intracerebral localization of brain electric activity during the two meditation conditions was compared using sLORETA functional EEG tomography. Differences between conditions were assessed using t statistics (corrected for multiple testing) on the normalized and log-transformed current density values of the sLORETA images. In the EEG alpha-2 frequency, 125 voxels differed significantly; all were more active during "Qigong" than "Thinking of Nothing," forming a single cluster in parietal Brodmann areas 5, 7, 31, and 40, all in the right hemisphere. In the EEG beta-1 frequency, 37 voxels differed significantly; all were more active during "Thinking of Nothing" than "Qigong," forming a single cluster in prefrontal Brodmann areas 6, 8, and 9, all in the left hemisphere. Compared to combined initial-final no-task resting, "Qigong" showed activation in posterior areas whereas "Thinking of Nothing" showed activation in anterior areas. The stronger activity of posterior (right) parietal areas during "Qigong" and anterior (left) prefrontal areas during "Thinking of Nothing" may reflect a predominance of self-reference, attention and input-centered processing in the "Qigong" meditation, and of control-centered processing in the "Thinking of Nothing" meditation.

    DOI PubMed

  • 日本語訳版EHS問診票の作成とそれを用いた調査(その1) 予備調査・日本語訳版EHS問診票の信頼性の検討

    北條 祥子, 土器屋 美貴子, 宮田 幹夫, 坂部 貢, 水城 まさみ, 石川 哲, 辻内 琢也, 本堂 毅, 乳井 美和子, 熊野 宏昭

    日本臨床環境医学会総会プログラム・抄録集   21回   np24 - np24  2012.05

  • 司会のことば(社会を動かすサイコセラピーの力,2011年,第52回日本心身医学会総会ならびに学術講演会(横浜))

    熊野 宏昭, 遊佐 安一郎

    心身医学   52 ( 9 ) 797 - 797  2012

    DOI CiNii

  • Behavior Analytic Intervention for Cognitive Responses in a Patient with Pnigophobia : A Case Study

    TAKAHASHI Fumito, OTSUKA Akiko, KUMANO Hiroaki

    Japanese journal of behavior therapy   38 ( 1 ) 23 - 33  2012.01

     View Summary

    The present case study describes treatment given to a man in his 40s who was reported to have pnigophobia (fear of choking) and some physical symptoms such as dysphagia (difficulty in swallowing). The treatment was based on a behavior analysis of the link between his covert cognitive responses and swallowing. The results of the behavior analysis suggested that simultaneous presentation of food in his mouth and his pnigophobic cognitions elicited the dysphagia which, in turn, reinforced his avoidance behavior. The treatment included exposure to body sensations and reciprocal inhibition of the cognitive response during swallowing. The client was asked to describe his body sensations in all phases of swallowing continuously. After this intervention, the client's physical symptoms were reduced; at 1-month and 3-month follow-ups, this improvement was found to have been maintained.

    CiNii

  • 「認知/行動療法」特集 : ポスト3・11時代の心身医療に新たな息吹を吹き込むために(<特集>認知/行動療法)

    熊野 宏昭

    心身医学   51 ( 12 )  2011.12

    CiNii

  • A Novel Methodology to Evaluate Health Impacts Caused by VOC Exposures Using Real-Time VOC and Holter Monitors

    Atsushi Mizukoshi, Kazukiyo Kumagai, Naomichi Yamamoto, Miyuki Noguchi, Kazuhiro Yoshiuchi, Hiroaki Kumano, Yukio Yanagisawa

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   7 ( 12 ) 4127 - 4138  2010.12  [Refereed]

     View Summary

    While various volatile organic compounds (VOCs) are known to show neurotoxic effects, the detailed mechanisms of the action of VOCs on the autonomic nervous system are not fully understood, partially because objective and quantitative measures to indicate neural abnormalities are still under development. Nevertheless, heart rate variability (HRV) has been recently proposed as an indicative measure of the autonomic effects. In this study, we used HRV as an indicative measure of the autonomic effrects to relate their values to the personal concentrations of VOCs measured by a real-time VOC monitor. The measurements were conducted for 24 hours on seven healthy subjects under usual daily life conditions. The results showed HF powers were significantly decreased for six subjects when the changes of total volatile organic compound (TVOC) concentrations were large, indicating a suppression of parasympathetic nervous activity induced by the exposure to VOCs. The present study indicated these real-time monitoring was useful to characterize the trends of VOC exposures and their effects on autonomic nervous system.

    DOI

  • Decreased response inhibition in middle-aged male patients with type 2 diabetes

    Kaya T. Ishizawa, Hiroaki Kumano, Atsushi Sato, Hiroshi Sakura, Yasuhiko Iwamoto

    BioPsychoSocial Medicine   4 ( 1 )  2010.02

     View Summary

    Background: This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC).Methods: Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controls underwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, and executive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin Card Sorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance, performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as a covariate.Results: Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task (discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time in the Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to the presentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performance in the WCST.Conclusions: Our results showed that middle-aged, newly diagnosed and medication-free patients with type 2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight. © 2010 Ishizawa et al
    licensee BioMed Central Ltd.

    DOI

  • Meditators and non-meditators: EEG source imaging during resting.

    Shisei Tei, Pascal L Faber, Dietrich Lehmann, Takuya Tsujiuchi, Hiroaki Kumano, Roberto D Pascual-Marqui, Lorena R R Gianotti, Kieko Kochi

    Brain topography   22 ( 3 ) 158 - 65  2009.11  [Refereed]  [International journal]

     View Summary

    Many meditation exercises aim at increased awareness of ongoing experiences through sustained attention and at detachment, i.e., non-engaging observation of these ongoing experiences by the intent not to analyze, judge or expect anything. Long-term meditation practice is believed to generalize the ability of increased awareness and greater detachment into everyday life. We hypothesized that neuroplasticity effects of meditation (correlates of increased awareness and detachment) would be detectable in a no-task resting state. EEG recorded during resting was compared between Qigong meditators and controls. Using LORETA (low resolution electromagnetic tomography) to compute the intracerebral source locations, differences in brain activations between groups were found in the inhibitory delta EEG frequency band. In the meditators, appraisal systems were inhibited, while brain areas involved in the detection and integration of internal and external sensory information showed increased activation. This suggests that neuroplasticity effects of long-term meditation practice, subjectively described as increased awareness and greater detachment, are carried over into non-meditating states.

    DOI PubMed

  • Evaluation of subjective symptoms of Japanese patients with multiple chemical sensitivity using QEESI

    Sachiko Hojo, Kou Sakabe, Satoshi Ishikawa, Mikio Miyata, Hiroaki Kumano

    Environmental Health and Preventive Medicine   14 ( 5 ) 267 - 275  2009.09

     View Summary

    Objectives The Quick Environment Exposure Sensitivity Inventory (QEESI) has been used as a questionnaire to evaluate subjective symptoms of patients with multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerance, in Japan. However, no cutoff value for Japanese subjects has yet been established. We designed this study to establish a cutoff value for Japanese subjects using QEESI(©) for screening of MCS patients. Methods A questionnaire using the QEESI© was administered to 103 MCS patients and 309 healthy control subjects matched for age and sex. QEESI© scores of the two groups were compared using logistic regression analysis, receiver operating characteristic analysis, and the Mann-Whitney test. Results Cutoff values for Japanese subjects were determined for the Chemical Intolerance subscale (40), Symptom Severity subscale (20), and Life Impact subscale (10). The subjects whose scores exceeded the cutoff values in any two subscales accounted for 88.4% of the patients but only 14.5% of the controls. Conclusions Our results suggest that subjects meeting two out of three subscale criteria can be screened as patients suffering from a low level of environmental chemicals such as MCS in Japan. © 2009 The Japanese Society for Hygiene.

    DOI

  • Mindfulness-based stress reduction and cancer: a meta-analysis

    Dianne Ledesma, Hiroaki Kumano

    PSYCHO-ONCOLOGY   18 ( 6 ) 571 - 579  2009.06  [Refereed]

     View Summary

    Objective: This meta-analysis was conducted to investigate the effects of mindfulness-based stress reduction (MBSR) on the mental and physical health status of various cancer patients.
    Methods: Tell studies (randomized-controlled trials and observational studies) were found to be eligible for meta-analysis. Individual study results were categorized into mental and physical variables and Cohen&apos;s effect size d was computed for each category.
    Results: MBSR may indeed be helpful for the mental health of cancer patients (Cohen&apos;s effect size d = 0.48); however, more research is needed to show convincing evidence of the effect on physical health (Cohen&apos;s effect size d = 0.18).
    Conclusion: The results suggest that MBSR may improve cancer patients&apos; psychosocial adjustment to their disease. Copyright (C) 2008 John Wiley & Sons, Ltd.

    DOI

  • Alterations in Brain Serotonin Synthesis in Male Alcoholics Measured Using Positron Emission Tomography

    Masami Nishikawa, Mirko Diksic, Yojiro Sakai, Hiroaki Kumano, Dara Charney, Jorge Palacios-Boix, Juan Negrete, Kathryn Gill

    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH   33 ( 2 ) 233 - 239  2009.02  [Refereed]

     View Summary

    A consistent association between low endogenous 5HT function and high alcohol preference has been observed, and a number of serotonergic manipulations (uptake blockers, agonists) alter alcohol consumption in animals and humans. Studies have also shown an inverse relationship between alcohol use and cerebrospinal fluid levels of serotonin metabolites, suggesting that chronic alcohol consumption produces alterations in serotonin synthesis or release.
    The objective of the study was to characterize regional brain serotonin synthesis in nondepressed chronic alcoholics at treatment entry in comparison to normal nonalcoholic controls using PET and the tracer alpha-[(11)C]-methyl-l-tryptophan.
    Comparisons of the alcoholics and controls by SPM found that there were significant differences in the rate of serotonin synthesis between groups. Serotonin synthesis was significantly lower among alcoholics in Brodmann Area (BA) 9, 10, and 32. However, serotonin synthesis among the alcoholics group was significantly higher than controls at BA19 in the occipital lobe and around the transverse temporal convolution in the left superior temporal gyrus (BA41). In addition, there were correlations between regional serotonin synthesis and a quantity-frequency measure of alcohol consumption. Regions showing a significant negative correlation with QF included the bilateral rectus gyri (BA11) in the orbitofrontal area, the bilateral medial frontal area (BA6), and the right amygdala.
    Current alcoholism is associated with serotonergic abnormalities in brain regions that are known to be involved in planning, judgment, self-control, and emotional regulation.

    DOI

  • QEESIを用いた日本の化学物質過敏症のスクリーニング用カットオフ値の設定および常時曝露化学物質の影響の検討

    北條 祥子, 熊野 宏昭, 石川 哲, 宮田 幹夫, 松井 孝子, 坂部 貢

    臨床環境医学   17 ( 2 ) 118 - 132  2008.12

     View Summary

    本研究の目的はQuick Environment Exposure Sensitivity Inventory(QEESI)を用いて一般人の中から化学物質過敏症(MCS)の疑いがある人をスクリーニングするための日本独自のカットオフ値を設定すること、また、喫煙などの常時に曝露する化学物質がMCSの発症に及ぼす影響を検討することである。北里研究所病院臨床環境医学センターでMCSと診断された103名とこれらの患者群と年齢性別をマッチングした対照群(健常者)309名に対し、QEESIを用いたアンケート調査を行った。患者群と対照群の自覚症状は、QEESIの4下位尺度40項目得点をロジスティック回帰分析および受信者動作特性曲線(ROC曲線)を用いて比較した。常時曝露化学物質の影響はマスキング尺度10項目のロジスティック回帰分析で検討した。MCSの自覚症状は、化学物質不耐性、症状、日常生活障害の3下位尺度で評価でき、カットオフ値は、それぞれ、40、20、10点と設定された。3下位尺度中いずれか2尺度がカットオフ値以上の人は、患者群では88.4%、健常者群では14.5%であった。そこで、日本では、化学物質不耐性40点以上、症状20点以上、日常生活障害10点以上のいずれか二つに該当する人を"MCSの疑いがある"としてスクリーニングできることが示唆された。常時曝露化学物質10項目のロジスティック回帰分析では、患者群が対照群より得点が高いもの(オッズ比1以上)と、患者群が対照群より得点が低いもの(オッズ比1以下)に明白に分類された。オッズ比15.0の仕事・趣味での化学物質使用とオッズ比4.7の殺虫剤・防虫剤は、日本のMCSの発症要因の一つである可能性が高い。一方、オッズ比1以下の5項目(喫煙、受動喫煙、飲酒、カフェイン摂取、柔軟剤使用)は患者の多くがこれらの要因で症状が悪化するため回避するようになった項目だと考えられる。(著者抄録)

  • QEESI問診票の日本独自のカットオフ値の設定

    北條 祥子, 熊野 宏昭, 石川 哲, 宮田 幹夫, 松井 孝子, 坂部 貢

    臨床環境医学   17 ( 2 ) 153 - 153  2008.12

  • 化学物質過敏症患者におけるVOC曝露と心拍変動のリアルタイムモニタリング

    水越 厚史, 熊谷 一清, 山本 尚理, 野口 美由貴, 吉内 一浩, 熊野 宏昭, 小沢 学, 松井 孝子, 坂部 貢, 柳沢 幸雄

    臨床環境医学   17 ( 2 ) 155 - 155  2008.12

  • Panic disorder and locomotor activity

    Noriyuki Sakamoto, Kazuhiro Yoshiuchi, Hiroe Kikuchi, Yoshiyuki Takimoto, Hisanobu Kaiya, Hiroaki Kumano, Yoshiharu Yamamoto, Akira Akabayashi

    BioPsychoSocial Medicine   2   23  2008.11

     View Summary

    Background: Panic disorder is one of the anxiety disorders, and anxiety is associated with some locomotor activity changes such as "restlessness". However, there have been few studies on locomotor activity in panic disorder using actigraphy, although many studies on other psychiatric disorders have been reported using actigraphy. Therefore, the aim of the present study was to investigate the relationship between panic disorder and locomotor activity pattern using a wrist-worn activity monitor. In addition, an ecological momentary assessment technique was used to record panic attacks in natural settings. Methods: Sixteen patients with panic disorder were asked to wear a watch-type computer as an electronic diary for recording panic attacks for two weeks. In addition, locomotor activity was measured and recorded continuously in an accelerometer equipped in the watch-type computer. Locomotor activity data were analyzed using double cosinor analysis to calculate mesor and the amplitude and acrophase of each of the circadian rhythm and 12-hour harmonic component. Correlations between panic disorder symptoms and locomotor activity were investigated. Results: There were significant positive correlations between the frequency of panic attacks and mesor calculated from double cosinor analysis of locomotor activity (r = 0.55) and between HAM-A scores and mesor calculated from double cosinor analysis of locomotor activity (r = 0.62). Conclusion: Panic disorder patients with more panic attacks and more anxiety have greater objectively assessed locomotor activity, which may reflect the "restlessness" of anxiety disorders. © 2008 Sakamoto et al
    licensee BioMed Central Ltd.

    DOI

  • Clinical characteristics of physician-diagnosed patients with multiple chemical sensitivity in Japan

    Sachiko Hojo, Satoshi Ishikawa, Hiroaki Kumano, Mikio Miyata, Kou Sakabe

    INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH   211 ( 5-6 ) 682 - 689  2008.10  [Refereed]

     View Summary

    Multiple chemical sensitivity (MCS), a syndrome in which multiple symptoms occur with low-level chemical exposure, has not been clarified in detail. The aim of our study was to clarify the clinical characterisitics of physician-diagnosed MCS patients in Japan. We analyzed patient characerisitics based on the medical records of 106 patients diagnosed with MCS according to the 1999 Consensus and the Japanese diagnostic criteria for MCS. We evaluated subjective symptoms using the Quick Environment Exposure Sensitivity Inventory (QEESI) and compared the QEESI scores with those of four MCS patient groups in the US reported by Miller and Prihoda [Miller, C.S., Prihoda, T.J., 1999b. A controlled comparison of symptoms and chemical intolerances reported by Gulf War veterans, implant recipients, and persons with multiple chemical sensitivity. Toxicol Ind Health 15, 386-397].
    Female patients accounted for 74.0%. Most male patients were in their 30s, whereas female ages ranged widely from 10 to 65 years. Among estimated onset factors, those seen in males tended to be workplace related, while female patients showed a variety of factors. Co-morbid allergic disease was present in 84.0% of patients. A significant difference in the QEESI score between male and female patients was found in only one item out of 10 in symptom severity and life impact. However, all 10 items in chemical intolerance were significantly higher in females than in males. The mean QEESI score in the patient group in our study was lower than those in any of the four self-reported patient groups in the US. (C) 2007 Elsevier GmbH. All rights reserved.

    DOI

  • QEESI問診票の日本独自のカットオフ値の設定

    北條 祥子, 熊野 宏昭, 石川 哲, 宮田 幹夫, 松井 孝子, 坂部 貢

    日本臨床環境医学会総会プログラム・抄録集   17回   26 - 26  2008.07

  • 化学物質過敏症患者におけるVOC曝露と心拍変動のリアルタイムモニタリング

    水越 厚史, 熊谷 一清, 山本 尚理, 野口 美由貴, 吉内 一浩, 熊野 宏昭, 小沢 学, 松井 孝子, 坂部 貢, 柳沢 幸雄

    日本臨床環境医学会総会プログラム・抄録集   17回   30 - 30  2008.07

  • Eating attitudes and body dissatisfaction in adolescents: Cross-cultural study

    Mami Kayano, Kazuhiro Yoshiuchi, Samir Al-Adawi, Nonna Viernes, Atsu S. S. Dorvlo, Hiroaki Kumano, Tomifusa Kuboki, Akira Akabayashi

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   62 ( 1 ) 17 - 25  2008.02  [Refereed]

     View Summary

    Aims: Sociocultural factors are thought to be important in the pathogenesis of eating disorders. However, there have been few studies comparing eating behavior among various cultural populations. The aim of the present study is to compare attitudes towards bodyweight and shape, and desire for thinness in Japanese male and female subjects with those in people from other countries and of different ethnic origin.
    Methods: The subjects were 411 Japanese, 130 Indian, 135 Omani, 113 Euro-American and 196 Filipino adolescents. The Eating Attitude Test-26 and the Drive for Thinness subscale of the Eating Disorder Inventory-2 were used to assess eating attitudes and fat phobia.
    Results: Subjects from India, Oman and the Philippines demonstrated eating attitudes that were similar to or worse than subjects from Western countries and Japan, although their desire for thinness was not as strong. The relationship between body mass index and eating attitudes or fat phobia in Indian, Omani and Filipino subjects differed from that in subjects from Western countries and Japan. In addition, both males and females showed disturbed eating attitudes in the Indian, Omani, and Filipino subjects. Conclusion: There are differences in eating attitudes and the drive for thinness among different cultural groups.

    DOI

  • Working Committee on Clinical Practice Guidelines for Late-onset Hypogonadism; Japanese Urological Association/Japanese Society for Study of Aging Male. Clinical practice manual for late-onset hypogonadism syndrome.

    Namiki M, Akaza H, Shimazui T, Ito N, Iwamoto T, Baba K, Kumano H, Koh E, Tsujimura A, Matsumiya K, Horie S, Maruyama O, Marumo K, Yanase T, Kumamoto Y

    Int J Urol   15 ( 5 ) 377 - 388  2008

  • Relationship between subtypes of irritable bowel syndrome and severity of symptoms associated with panic disorder

    Nagisa Sugaya, Hisanobu Kaiya, Hiroaki Kumano, Shinobu Nomura

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   43 ( 6 ) 675 - 681  2008  [Refereed]

     View Summary

    Objective. To investigate the relationship between subtypes of irritable bowel syndrome (IBS) and severity of symptoms associated with panic disorder (PD). Material and methods. The study comprised 178 consecutive new PD outpatients. Sixty-four patients met the Rome-II criteria for IBS (IBS[+]; 29 diarrhea-predominant IBS (IBSD), 14 constipation-predominant IBS (IBSC), 21 other types of IBS). Results. IBSD patients with agoraphobia avoided a greater number of scenes owing to fear of panic attack than did PD patients without IBS (IBS[-]) and with agoraphobia. IBS[+] patients with avoidant behavior due to fear of IBS symptoms had significantly higher Beck Depression Inventory (BDI) scores and avoided a larger number of scenes owing to fear of panic attack than IBS[+] patients with agoraphobia and without avoidant behavior due to fear of IBS symptoms or IBS[-] patients with agoraphobia. Conclusions. The results suggest that the presence of IBSD or avoidant behavior because of fear of IBS symptoms may be associated with a more severe form of agoraphobia, and the latter may also be associated with depression.

    DOI

  • 日本の化学物質過敏症患者の臨床的特徴 性別、年齢、発症要因、アレルギー疾患、自覚症状、他覚的臨床検査結果

    北條 祥子, 石川 哲, 熊野 宏昭, 宮田 幹夫, 松井 孝子, 坂部 貢

    臨床環境医学   16 ( 2 ) 104 - 116  2007.12

     View Summary

    本研究の目的は日本の化学物質過敏症(MCS)患者の臨床的特徴を明らかにし、診断に有効な他覚的臨床検査について検討することである。そこで、北里研究所病院臨床環境医学センターの外来患者で、MCSと診断された患者106名のカルテを基に、性別、年齢、発症要因、アレルギー疾患、自覚症状の性差及び他覚臨床検査結果について解析した。患者の74%は女性であった。84%の患者が何らかのアレルギー疾患を有していた。男性は若年者が多く発症要因は職場関連の化学物質曝露が大部分を占めたのに対し、女性は幅広い年齢分布を示し推定発症要因も多彩であった。自覚症状はquick environment exposure sensitivity inventory(QEESI)で評価し、男女の得点を比較した。症状と日常生活障害は男女で有意差がなかったが、化学物質不耐性は全項目で女性が男性より有意に得点が高かった。他覚的臨床検査(滑動性眼球追従運動、視空間周波数特性、瞳孔反応、神経反射)の陽性率は、それぞれ、85.8、69.8、46.7、54.1%であり、これら4つの検査がすべて陰性だった患者はいなかった。神経眼科的検査結果からは、MCS患者の多彩な自覚症状は高位の中枢神経や自律神経系の機能異常に起因することが示唆された。(著者抄録)

  • A real-time assessment of the effect of exercise in chronic fatigue syndrome

    Kazuhiro Yoshiuchi, Dane B. Cook, Kyoko Ohashi, Hiroaki Kumano, Tomifusa Kuboki, Yoshiharu Yamamoto, Beniamin H. Natelson

    PHYSIOLOGY & BEHAVIOR   92 ( 5 ) 963 - 968  2007.12  [Refereed]

     View Summary

    Patients with chronic fatigue syndrome (CFS) report substantial symptom worsening after exercise. However, the time course over which this develops has not been explored. Therefore, the objective of this study was to investigate the influence of exercise on subjective symptoms and on cognitive function in CFS patients in natural settings using a computerized ecological momentary assessment method, which allowed us to track the effects of exercise within and across days. Subjects were 9 female patients with CFS and 9 healthy women. A watch-type computer was used to collect real-time data on physical and psychological symptoms and cognitive function for 1 week before and 2weeks after a maximal exercise test. For each variable, we investigated temporal changes after exercise using multilevel modeling. Following exercise, physical symptoms did get worse but not until a five-day delay in CFS patients. Despite this, there was no difference in the temporal pattern of changes in psychological symptoms or in cognitive function after exercise between CFS patients and controls. In conclusion, physical symptoms worsened after several days delay in patients with CFS following exercise while psychological symptoms or cognitive function did not change after exercise. (C) 2007 Elsevier Inc. All rights reserved.

    DOI

  • Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT(2C) receptor inactivation induce appetite-sup pressing effects in mice via 5-HT(1B) receptors

    Katsunori Nonogaki, Kana Nozue, Yukiko Takahashi, Nobuyuki Yamashita, Shuichi Hiraoka, Hiroaki Kumano, Tomifusa Kuboki, Yohsitomo Oka

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY   10 ( 5 ) 675 - 681  2007.10  [Refereed]

     View Summary

    Serotonin (5-hydroxytryptamine; 5-HT) 2C receptors and the downstream melanocortin pathway are suggested to mediate the appetite-suppressing effects of 5-HT drugs such as m-chlorophenylpiperazine (mCPP) and fenfluramine. Here, we report that fluvoxamine (3-30 mg/kg), a selective serotonin reuptake inhibitor (SSRI), in the presence of SB 242084 (1-2 mg/kg), a selective 5-HT(2C) receptor antagonist, exerts appetite-suppressing effects while fluvoxamine or SB 242084 alone has no effect. The appetite-suppressing effects were attenuated in the presence of SB 224289 (5 mg/kg), a selective 5-HT(1B) receptor antagonist. Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT(1B) receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression. These results suggest that fluvoxamine and inactivation of 5-HT(2C) receptors exert feeding suppression through activation of 5-HT(1B) receptors, and that 5-HT(1B) receptors up-regulate hypothalamic POMC and CART gene expression and down-regulate hypothalamic orexin gene expression in mice.

    DOI

  • Tendency toward deliberate food restriction, fear of fatness and somatic attribution in cross-cultural samples

    Nonna Viernes, Ziad A.J. Zaidan, Atsu S.S. Dorvlo, Mami Kayano, Kazuhiro Yoishiuchi, Hiroaki Kumano, Tomifusa Kuboki, Samir Al-Adawi

    Eating Behaviors   8 ( 3 ) 407 - 417  2007.08

     View Summary

    Objective: To compare Omani and western teenagers attending schools in Muscat, Sultanate of Oman and Filipino teenagers residing in Manila, Philippines on indices of deliberate food restriction and dieting behavior. Methods: The sample consisted of 444 students who were assessed using the cross-culturally valid measure, Eating Attitude Test-26, a subscale of Eating Disorder Inventory to gauge the presence of the drive for thinness or 'fat phobia' and the Bradford Somatic Inventory to elicit the presence of somatization. Result: Significant differences in attitudes to eating, body image and somatization between the western and non-western teenagers were found. Conclusion: This paper suggests that trajectories of eating disorder, such as body image disturbances as expressed in fat phobia and somatization, tend to vary from culture to culture and underscore the view that some of the health related behavior among adolescents need to be examined within socio-cultural contexts. © 2007 Elsevier Ltd. All rights reserved.

    DOI PubMed

  • 化学物質過敏症の実態と対策 化学物質過敏症患者における日常生活下での心拍変動・体動の検討

    熊野 宏昭, 石澤 哲朗, 吉内 一浩, 赤林 朗, 坂部 貢, 宮田 幹夫, 石川 哲

    アレルギー   56 ( 3-4 ) 265 - 265  2007.04

  • Indoor air contaminants as the most common onset factor of multiple chemical sensitivity in Japan

    Sachiko Hojo, Hiroaki Kumano, Satoshi Ishikawa, Mikio Miyata, Takako Matsui, Kou Sakabe

    IAQVEC 2007 Proceedings - 6th International Conference on Indoor Air Quality, Ventilation and Energy Conservation in Buildings: Sustainable Built Environment   1   563 - 568  2007

     View Summary

    The purposes of this study were to clarify the characteristics of physician-diagnosed MCS patients in Japan. Thus, based on the medical records of 106 patients diagnosed with MCS according to both the 1999 Consensus and the Japanese diagnostic criteria for MCS, we analyzed demographic characteristics (sex and age), onset factors, co-morbid allergic diseases. In addition, subjective symptoms were evaluated using the QEESI®, and we compared the QEESI® scores with those of four MCS patient groups in the U.S. reported by Miller and Prihoda (1999b). Female patients accounted for 74.0%. The peak age in males was 30-34 years, whereas females showed a wide age distribution with three peaks, 30-34, 45-49 and 60-64 years. The most common MCS onset factors included indoor air contaminants by new construction or renovation of home or work place (63.2%), followed by exposure to chemicals in workspace or hobby (26 3%). In addition, co-morbid allergic disease was presented for 84.0%.

  • "Mobile nurse" platform for ubiquitous medicine

    Z. R. Struzik, K. Yoshiuchi, M. Sone, T. Ishikawa, H. Kikuchi, H. Kumano, T. Watsuji, B. H. Natelson, Y. Yamamoto

    METHODS OF INFORMATION IN MEDICINE   46 ( 2 ) 130 - 134  2007  [Refereed]

     View Summary

    Objectives: We introduce "Mobile Nurse" (MN)-an emerging platform for the practice of ubiquitous medicine.
    Methods: By implementing in a dynamic setting of daily life the patient care traditionally provided by the clinical nurses on duty, MN aims at integral data collection and shortening the response time to the patient MN is also capable of intelligent interaction with the patient and is able to learn from the patient's behavior and disease sign evaluation for improved personalized treatment.
    Results: In this paper, we outline the most essential concepts around the hardware, software and methodological designs of MN. We provide an example of the implementation, and elaborate on the possible future impact on medical practice and biomedical science research.
    Conclusions: The main innovation of MN, setting it apart from current tele-medicine systems, is the ability to integrate the patient's signs and symptoms on site, providing medical professionals with powerful tools to elucidate disease mechanisms, to make proper diagnoses and to prescribe treatment.

  • The development of a Japanese version of the Short-form McGill Pain Questionnaire.

    Yamaguchi M, Kumano H, Yamauchi Y, Kadota Y, Iseki M

    The Journal of the Japan Society of Pain Clinicians   14   9 - 14  2007

  • 日本のMCS患者に対するQEESI問診票の有効性の検討

    北條 祥子, 坂部 貢, 宮田 幹夫, 熊野 宏昭, 吉野 博, 角田 和彦, 松井 孝子, 石川 哲

    臨床環境医学   15 ( 2 ) 151 - 151  2006.12

  • 日本のMCS患者の自覚症状・他覚的臨床検査・推定発症要因

    北條 祥子, 坂部 貢, 宮田 幹夫, 松井 孝子, 熊野 宏昭, 石川 哲

    臨床環境医学   15 ( 2 ) 164 - 164  2006.12

  • Reliability of recalled self-report on headache intensity: investigation using ecological momentary assessment technique

    H. Kikuchi, K. Yoshiuchi, N. Miyasaka, K. Ohashi, Y. Yamamoto, H. Kumano, T. Kuboki, A. Akabayashi

    CEPHALALGIA   26 ( 11 ) 1335 - 1343  2006.11  [Refereed]

     View Summary

    Recalled evaluation of headache intensity is often affected by several factors. Recently, computerized ecological momentary assessment (EMA) has been developed to avoid such problems as recall bias. Here, we compared recalled headache intensity with momentary headache intensity using EMA in tension-type headache (TTH). Forty patients with TTH wore watch-type computers for 1 week to record momentary headache intensity and also rated their headache intensities by recall. We calculated intraclass correlation coefficients between recalled headache intensity and indices from EMA recordings in the whole study population and in two subgroups divided by variability of momentary headache intensity. The results showed that consistency and agreement of momentary and recalled headache intensity were low, and this was especially marked in the subjects whose headache varied widely. These observations suggested that variability of headache intensity may affect recall of headache intensity and this should be taken into consideration in both clinical and research settings.

    DOI

  • Changes in cerebral glucose utilization in patients with panic disorder treated with cognitive-behavioral therapy

    Yojiro Sakai, Hiroaki Kumano, Masami Nishikawa, Yuji Sakano, Hisanobu Kaiya, Etsuko Imabayashi, Takashi Ohnishi, Hiroshi Matsuda, Asako Yasuda, Atsushi Sato, Mirko Diksic, Tomifusa Kuboki

    NEUROIMAGE   33 ( 1 ) 218 - 226  2006.10  [Refereed]

     View Summary

    Several neuroanatomical hypotheses of panic disorder have been proposed focusing on the significant role of the amygdala and PAG-related "panic neurocircuitry." Although cognitive-behavioral therapy is effective in patients with panic disorder, its therapeutic mechanism of action in the brain remains unclear. The present study was performed to investigate regional brain glucose metabolic changes associated with successful completion of cognitive-behavioral therapy in panic disorder patients. The regional glucose utilization in patients with panic disorder was compared before and after cognitive-behavioral therapy using positron emission tomography with F-18-fluorodeoxyglucose. In 11 of 12 patients who showed improvement after cognitive-behavioral therapy, decreased glucose utilization was detected in the right hippocampus, left anterior cingulate, left cerebellum, and pons, whereas increased glucose utilization was seen in the bilateral medial prefrontal cortices. Significant correlations were found between the percent change relative to the pretreatment value of glucose utilization in the left medial prefrontal cortex and those of anxiety and agoraphobia-related subscale of the Panic Disorder Severity Scale, and between that of the midbrain and that of the number of panic attacks during the 4 weeks before each scan in all 12 patients. The completion of successful cognitive-behavioral therapy involved not only reduction of the baseline hyperactivity in several brain areas but also adaptive metabolic changes of the bilateral medial prefrontal cortices in panic disorder patients. (c) 2006 Elsevier Inc. All rights reserved.

    DOI

  • Changes in heart rate with refeeding in anorexia nervosa: A pilot study

    Nahoko (Miyasaka) Yoshida, Kazuhiro Yoshiuchi, Hiroaki Kumano, Tadashi Sasaki, Tomifusa Kuboki

    JOURNAL OF PSYCHOSOMATIC RESEARCH   61 ( 4 ) 571 - 575  2006.10  [Refereed]

     View Summary

    Objective: To find differences in heart rate before and after refeeding and to identify which parameters of autonomic activity and endocrine function are associated with these differences.
    Methods: Before and after the start of refeeding, body weight, RR interval (RRI), heart rate variability, endocrine function, and energy expenditure were measured in nine female anorexia nervosa patients.
    Results: After short-term refeeding, mean daytime heart rate rose from 54.9 to 69.4 bpm (P &lt; .05). The changes in sympathetic activity were correlated negatively with the changes in RRI (r = -.933, P &lt; .001). Urine C-peptide, IGF-1, and fT3 increased significantly, and norepinephrine tended to increase.
    Conclusion: We demonstrated that autonomic nervous activity was relevant to changes in heart rate during refeeding, and it is speculated that the increases in insulin secretion, thyroid function, and IGF-I were responsible for the mechanisms. (c) 2006 Elsevier Inc. All rights reserved.

    DOI

  • 日本のMCS患者に対するQEESI問診票の有効性の検討

    北條 祥子, 坂部 貢, 宮田 幹夫, 熊野 宏昭, 吉野 博, 角田 和彦, 松井 孝子, 石川 哲

    日本臨床環境医学会総会プログラム・抄録集   15回   39 - 39  2006.07

  • 日本のMCS患者の自覚症状・他覚的臨床検査・推定発症要因

    北條 祥子, 坂部 貢, 宮田 幹夫, 松井 孝子, 熊野 宏昭, 石川 哲

    日本臨床環境医学会総会プログラム・抄録集   15回   45 - 45  2006.07

  • Yearlong physical activity and depressive symptoms in older Japanese adults: cross-sectional data from the Nakanojo study.

    Kazuhiro Yoshiuchi, Rika Nakahara, Hiroaki Kumano, Tomifusa Kuboki, Fumiharu Togo, Eiji Watanabe, Akitomo Yasunaga, Hyuntae Park, Roy J Shephard, Yukitoshi Aoyagi

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry   14 ( 7 ) 621 - 4  2006.07  [Refereed]  [International journal]

     View Summary

    OBJECTIVE: The objective of this study was to investigate associations between accelerometer measurements of physical activity and psychosocial variables in older people. METHODS: Subjects were 184 Japanese aged 65-85 years. An accelerometer provided step count and physical activity intensity data throughout each 24-hour period for 1 year. At the end of the year, anxiety, depression, and cognitive function were assessed. RESULTS: Controlling for age, the daily number of steps, and the daily duration of moderate-intensity physical activity showed significant negative correlations with depressive mood. CONCLUSION: A depressive mood is associated with the quantity and quality of habitual physical activity.

    PubMed

  • 化学物質過敏症患者における体動パターンの検討

    石澤 哲郎, 吉内 一浩, 熊野 宏昭, 赤林 朗, 坂部 貢, 石川 哲

    心身医学   46 ( 6 ) 544 - 544  2006.06

  • Prospective study on influence of psychosocial factors on glycemic control in Japanese patients with Type 2 diabetes

    R Nakahara, K Yoshiuchi, H Kumano, Y Hara, H Suematsu, T Kuboki

    PSYCHOSOMATICS   47 ( 3 ) 240 - 246  2006.05  [Refereed]

     View Summary

    The authors prospectively assessed the causal relationship between psychosocial factors and glycemic control in 256 Japanese outpatients with Type 2 diabetes. Using structural-equation modeling, they first developed a causal model in which glycosylated hemoglobin (HbA(1c)) at 6 months after assessment was influenced by the baseline psychosocial factors. Then, the reliability of the causal model was investigated with measurement of HbA(1c) at 12 months after baseline. Self-efficacy directly reinforced adherence, and adherence had a direct association with future HbA(1c) Other psychosocial factors, including social support, diabetes-related distress, daily burden, and emotion-focused coping prospectively influenced HbA(1c) indirectly through self-efficacy.

  • Does the Aging Males' Symptoms scale assess major depressive disorder?: A pilot study

    N Yoshida, H Kumano, T Kuboki

    MATURITAS   53 ( 2 ) 171 - 175  2006.01  [Refereed]

     View Summary

    Objectives: The objectives of the study were to find the prevalence of major depressive disorder (MDD) in male climacteric outpatients in Japan, and to determine whether symptoms on the Aging Males' Symptoms (AMS) scale scores differed between patients with and without MDD, with the aim of increasing the specificity of future symptoms scales for partial androgen deficiency of the aging male (PADAM).
    Methods: Eighty-three patients aged 40-70 who visited the male-climacteric services as outpatients were assessed using three items: a self-administered questionnaire corresponding to diagnosis for MDD, the Beck Depression Inventory, and the AMS scale.
    Results: Almost half the patients had MDD. The total AMS score, the scores on the AMS psychological, somatic and sexual subscales, and the scores for all except three questionnaire symptoms were higher in patients with MDD. There were strong correlations between the AMS scale and the Beck Depression Inventory.
    Conclusions: There is a higher prevalence of MDD in male-climacteric outpatients and scores on most items of the AMS scale were higher for patients with MDD. We suggest that only those symptoms whose scores did not differ between patients with and without MDD are used to assess symptoms of PADAM in the presence of MDD, or that the current AMS is used only after diagnosis of MDD and elimination of these patients. Then the relevance of each item of the AMS to testosterone levels should be simultaneously examined in the future study, which will determine the items highly specific to PADAM symptoms. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

    DOI

  • Bulimia nervosa and abnormal cardiac repolarization

    Y Takimoto, K Yoshiuchi, H Kumano, T Kuboki

    JOURNAL OF PSYCHOSOMATIC RESEARCH   60 ( 1 ) 105 - 107  2006.01  [Refereed]

     View Summary

    Objective: Eating disorders (ED) are thought to be risk factors for sudden death, and arrhythmias are one of the major causes of sudden death in ED patients. Late potentials (LPs) are a predictor of arrhythmias and can be measured using signal-averaged electrocardiography (SAECG). We examined arrhythmogecity by LPs in ED patients. Methods: We performed SAECG on 48 female ED patients [21 with anorexia nervosa (AN) and 27 with bulimia nervosa (BN)] and on 20 healthy women. An LP was judged positive if two or more of the following criteria were fulfilled: QRS duration &gt; 120 ms, root-mean-square voltage &lt; 20 mu V, and a high-frequency, low-amplitude duration &gt; 38 ms. We compared the occurrence of LPs among subgroups. Results: Compared with the controls, BN patients with a history of AN had significantly more SAECG abnormalities. Conclusions: BN patients with a history of AN may be prone to ventricular arrhythmias. (c) 2006 Elsevier Inc. All rights reserved.

    DOI

  • 尿路結石を繰り返した神経性食欲不振症の1例

    森屋 淳子, 古田 寿宏, 坂本 典之, 鶴ヶ野 しのぶ, 吉内 一浩, 熊野 宏昭, 久保木 富房

    心身医学   45 ( 12 ) 947 - 948  2005.12

  • 精神的外傷を引き起こす死別の社会文化的背景への一考察-説明モデルとしてのオマーンのZombification-.

    Samir Al-Adawi, 鄭 志誠, 辻内琢也, 葉山玲子, 吉内一浩, 熊野宏昭, 久保木富房

    心身医学   45 ( 12 ) 933 - 941  2005.12

  • Analysis of energy expenditure, endocrine function, and autonomic nervous activity in anorexia nervosa patients during refeeding

    NM Yoshida, K Yoshiuchi, H Kumano, T Sasaki, T Kuboki

    NUTRITION RESEARCH   25 ( 11 ) 959 - 970  2005.11  [Refereed]

     View Summary

    Resting energy expenditure (REE) increases in anorexia nervosa patients after refeeding; however, the associated mechanisms remain unclear. We hypothesized that changes in autonomic nervous activity are relevant to changes in REE during refeeding. The objectives of this study were (1) to confirm differences in REE during refeeding and (2) to identify the parameters associated with these differences. The subjects were 9 female inpatients with anorexia nervosa receiving cognitive-behavioral therapy. Both before and after the start of refeeding, which was defined as the first increase in food intake of 1675 kj or more per day, body composition, REE, endocrine function, R-R interval, autonomic nervous activity evaluated in terms of heart rate variability, and physical activity were measured and psychological tests completed. The differences in measurements before and after refeeding and specific associations between changes in REE and other factors were assessed. Resting energy expenditure increased significantly by 22.7% from 3190 to 3910 kj/d (P &lt; .01) with the increase in energy intake. Fat-free mass and physical activity did not change. The increase in REE was accompanied by higher insulin-like growth factor-I, free triiodothyronine, and norepinephrine and decreases in parasympathetic activity and R-R interval. Some factors might be responsible for the increases in REE observed with refeeding. No previous study has simultaneously observed multiple variables related to energy metabolism during refeeding. (c) 2005 Elsevier Inc. All rights reserved.

    DOI

  • パーソナリティと生活習慣,食行動および生理指標との関連性の検討-Short Interpersonal Reactions Inventory (SIRI) 日本語短縮版を用いた分析.

    織井優貴子, 熊野宏昭, 宗像正徳, 福土審

    心身医学   45 ( 11 ) 849 - 854  2005.11

  • A placebo-controlled, randomized withdrawal study of sertraline for panic disorder in Japan

    K Kamijima, T Kuboki, H Kumano, T Burt, G Cohen, Arano, I, T Hamasaki

    INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY   20 ( 5 ) 265 - 273  2005.09  [Refereed]

     View Summary

    The objective of this double-blind, placebo-controlled randomized withdrawal study was to evaluate the efficacy and safety of sertraline for 8 weeks in treating Japanese patients with DSM-IV panic disorder. Patients (n=394) were initially treated with 8 weeks of open-label sertraline followed by 8 weeks of double-blind treatment with either sertraline (50-100 mg/day) or placebo. Responders during the open-label phase were eligible to be entered into the double-blind phase. Two hundred and forty patients were entered to the double-blind phase and randomly assigned to receive sertraline (n=119) or placebo (n=121). On the primary efficacy measure (relapse), there was no significant difference between the two treatment groups (sertraline 10.1 %; placebo 13.2%). However, the frequency of panic attacks was significantly (P=0.012) lower for sertraline compared to placebo. The proportion of sertraline-treated patients who met response criteria (Clinical Global Impression-Improvement Scale score of 1 or 2) at the end of double-blind phase treatment was also significantly (P=0.003) higher for sertraline (89.9%) compared to placebo (74.4%). Panic Disorder Severity Scale total score was significantly (P=0.012) lower in the sertraline group compared to the placebo group. Adverse events during acute treatment were consistent with the known adverse event profile of sertraline, and the incidence of adverse events during the double-blind phase treatment was not different between sertraline and placebo. Int Clin Psychopharmacol. (c) 2005 Lippincott Williams & Wilkins.

  • Harmony seeking and the risk of prostate cancer: A prebioptic study

    H Kumano, E Haseme, H Fujimoto, N Matsuoka, K Yoshiuchi, Y Uchitomi, T Akechi, T Nakano, M Kobayashi, Agari, I, T Kuboki

    JOURNAL OF PSYCHOSOMATIC RESEARCH   59 ( 3 ) 167 - 174  2005.09  [Refereed]

     View Summary

    Objective: This semiprospective case-control study was performed to investigate the relationship between harmony-seeking personality and the occurrence of prostate cancer. Methods: Out of 217 consecutive participants admitted to hospital for biopsy, 86 and 81 were classified into the case and control groups, respectively, based on their initial diagnosis and eligibility criteria. The participants answered several questionnaires after admission. The logistic regression model was used for multivariate analyses to assess the association. Results: "Harmony-seeking personality" was selected as the only psychological variable significantly contributing to the model, while "family history of prostate cancer" as the only somatic variable. "Harmony-seeking" maintained a significant contribution to the model, also including "family history" and even to the model adjusted by "patient prediction of cancer diagnosis" and "prostate-specific antigen" (PSA), probably related to the consequences of the disease. Conclusion: The harmony-seeking personality could differentiate between groups of men with and without prostate cancer. (c) 2005 Elsevier Inc. All rights reserved.

    DOI

  • Cerebral glucose metabolism associated with a fear network in panic disorder

    Y Sakai, H Kumano, M Nishikawa, Y Sakano, H Kaiya, E Imabayashi, T Ohnishi, H Matsuda, A Yasuda, A Sato, M Diksic, T Kuboki

    NEUROREPORT   16 ( 9 ) 927 - 931  2005.06  [Refereed]

     View Summary

    The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. F-18-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network. NeuroReport 16:927-931 (c) 2005 Lippincott Williams & Wilkins.

  • Explicit knowledge and intention to learn in sequence learning: an event-related potential study

    K Miyawaki, A Sato, A Yasuda, H Kumano, T Kuboki

    NEUROREPORT   16 ( 7 ) 705 - 708  2005.05  [Refereed]

     View Summary

    The present study was performed to examine how intention to learn and explicit knowledge in sequence learning are reflected in event-related potentials. Participants responded to numerals presented in a repeating order, which were replaced infrequently by deviant numerals. The participants were given incidental or intentional learning instructions. Sequence parts for which they acquired explicit knowledge were identified for each participant by post-task memory tests. Reaction times indicated that sequence learning occurred under both types of instruction. The N2 enhancement for deviants was primarily associated with explicit sequence knowledge, and the P3 enhancement showed a weak association. These results suggested that N2 and P3 reflect different aspects of explicit learning. NeuroReport 16:705-708 &COPY; 2005 Lippincott Williams & Wilkins.

  • Use of QEESI (c) questionnaire for a screening study in Japan

    S Hojo, H Yoshino, H Kumano, K Kakuta, M Miyata, K Sakabe, T Matsui, K Ikeda, A Nozaki, S Ishikawa

    TOXICOLOGY AND INDUSTRIAL HEALTH   21 ( 5-6 ) 113 - 124  2005.05  [Refereed]

     View Summary

    QEESI (c) (Miller and Prihoda, 1999a: Toxicology and Industrial Health, 15, 370) was applied to 498 subjects, recruited from the general population of Miyagi prefecture, Japan, who had not been diagnosed previously as having multiple chemical sensitivity (MCS) or sick building syndrome.
    Seventeen (3.8%) of 440 subjects who returned valid completed questionnaires were classified as having symptoms 'very suggestive' of MCS using the four-classification system of Miller and Prihoda (1999a). We conducted detailed telephone interviews with these 17 individuals. All were visiting local hospitals on an outpatient basis with diagnoses other than MCS and had either current or previous presumed chemical exposure. Therefore, we recommended they undergo a medical check by MCS medical experts and indoor air quality assessment.
    Seven subjects participated in both the medical check and indoor air quality monitoring, six subjects participated in indoor air quality monitoring only and four subjects participated in neither. The seven subjects who participated in both the medical check and monitoring were diagnosed as having MCS by the above expert physicians. In nine houses of 13 subjects who participated in indoor environmental quality (IEQ) survey, acetaldehyde (9/9), formaldehyde (8/9), total volatile compounds (TVOCs) (6/9) and paradichlorobenzene (3/9) levels were above the respective guideline values for indoor air concentrations, outlined by the Ministry of Health, Labor and Welfare of Japan and were presumed to act as factors contributing to the subjects' hypersensitivity and onset or development of symptoms.
    These results suggested that there might still be a population of patients not properly diagnosed as having MCS by clinicians in Japan. Therefore, we verified the efficacy of QEESI (Japanese version) for screening of MCS patients.
    The results of indoor air quality analysis suggested the manifestation and deterioration of MCS in Japan might be precipitated by indoor air pollutants, such as formaldehyde, acetaldehyde, volatile compounds (VOCs) and paradichlorobenzene.

    DOI

  • ストレスと自律神経系 基礎から臨床へ ストレスと自律神経症状 EMAを応用してリアルタイムに捉える

    菊地 裕絵, 吉内 一浩, 齊藤 麻里子, 石澤 哲郎, 熊野 宏昭, 久保木 富房

    自律神経   42 ( 2 ) 125 - 129  2005.04

  • Effects of value and reward magnitude on feedback negativity and P300

    A Sato, A Yasuda, H Ohira, K Miyawaki, M Nishikawa, H Kumano, TL Kuboki

    NEUROREPORT   16 ( 4 ) 407 - 411  2005.03  [Refereed]

     View Summary

    Feedback negativity is a negative component of the event-related brain potential observed 250-300 ms after feedback stimuli. The present study investigated the effects of value (correct or incorrect) and reward magnitude (no, small or large) on feedback negativity and P300. Feedback negativity was larger after incorrect feedback than after correct feedback, irrespective of reward magnitude. In contrast, P300 amplitude increased with reward magnitude, irrespective of value. The amplitude of feedback negativity was correlated with a trait score of negative affect and not positive affect, whereas P300 amplitude was correlated with positive affect and not negative affect. These results suggest that value and reward magnitude are processed separately in the brain. (c) 2005 Lippincott Williams F Wilkins.

  • Symptom profile of multiple chemical sensitivity in actual life

    M Saito, H Kumano, K Yoshiuchi, N Kokubo, K Ohashi, Y Yamamoto, N Shinohara, Y Yanagisawa, K Sakabe, M Miyata, S Ishikawa, T Kuboki

    PSYCHOSOMATIC MEDICINE   67 ( 2 ) 318 - 325  2005.03  [Refereed]

     View Summary

    Objective: This study was conducted to confirm the definition of multiple chemical sensitivity (MCS) in actual life: that multiple symptoms are provoked in multiple organs by exposure to, and ameliorated by avoidance of, multiple chemicals at low levels. We used the Ecological Momentary Assessment to monitor everyday symptoms and the active sampling and passive sampling methods to measure environmental chemical exposure. Methods: Eighteen patients with MCS, diagnosed according to the 1999 consensus criteria, and 12 healthy controls participated in this study. Fourteen patients and 12 controls underwent 1-week measurement of physical and psychologic symptoms and of the levels of exposure to various chemicals. Linear mixed models were used to test the hypotheses regarding the symptom profile of MCS patients. Results: Some causative chemicals were detected in 11 of 14 MCS patients. Two other patients did not report any hypersensitivity episodes, whereas passive sampling showed far less exposure to chemicals than control subjects. Another subject reported episodic symptoms but was excluded from the following analyses because no possible chemical was detected. Eleven of the 17 physical symptoms and all four mood subscales examined were significantly aggravated in the interview based on "patient-initiated symptom prompts." On the other hand, there were no differences in physical symptoms or mood subscales between MCS patients and control subjects in the interview based on "random prompts." Conclusions: MCS patients do not have either somatic or psychologic symptoms under chemical-free conditions, and symptoms may be provoked only when exposed to chemicals.

    DOI

  • Possible interactive effects of demographic factors and stress coping mechanisms on depression and anxiety in maintenance hemodialysis patients

    J Takaki, T Nishi, H Shimoyama, T Inada, N Matsuyama, H Kumano, T Kuboki

    JOURNAL OF PSYCHOSOMATIC RESEARCH   58 ( 3 ) 217 - 223  2005.03  [Refereed]

     View Summary

    Objective: The aim of this study was to assess the possible interactive effects of age, sex, duration of hemodialysis (HD), educational and income levels, and stress coping mechanisms on depression and anxiety in patients on maintenance HD. Methods: Uremic patients (N = 416), regularly undergoing HD for more than I year, who did not have apparent cerebrovascular disease or serious intellectual impairment, were investigated. The interactive effects of age, sex, duration of HD, and educational and income levels, in relation to stress coping mechanisms, on depression or anxiety were assessed by hierarchical multiple regression analyses. Results: Regression lines illustrating significant (P&LT;.05) interactions were constructed. The decrease in depression accompanying the increase in task-oriented stress coping was greater in highly educated patients than it was in the other patients. Anxiety levels decreased when patients had both high income and demonstrated a range of task-oriented stress coping mechanisms. For patients undergoing HD for tong duration, or with a relatively high income, the decrease of depression and anxiety accompanying a decrease of emotion-oriented stress coping was greater, as compared with other patients. The decrease of depression accompanying an increase of avoidance-oriented stress coping was greater in patients with low income and in older patients than it was in the other patients. Conclusions: These findings may lead to the development of specific and focused interventions for depression or anxiety in maintenance HD patients. &COPY; 2005 Elsevier Inc. All rights reserved.

    DOI

  • 民俗セクター医療を利用する患者の社会文化的背景—医療人類学的視点による質的研究.

    辻内琢也, 鈴木勝己, 辻内優子, 熊野宏昭, 久保木富房

    心身医学   45 ( 1 ) 53 - 62  2005

  • 日本人に対するQEESI応用の試み-QEESIのMCSおよびシックハウス症候群患者のスクリーニング用問診票として使用事例-.

    北條祥子, 吉野博, 熊野宏昭, 角田和彦, 宮田幹夫, 坂部貢, 松井孝子, 池田耕一, 野崎敦夫, 石川哲

    臨床環境医学   13 ( 2 ) 110 - 119  2005

  • 心身医療における病いの語り:文化人類学による質的研究(第1報).

    鈴木勝己, 辻内琢也, 辻内優子, 熊野宏昭, 久保木富房

    心身医学   45 ( 6 ) 449 - 457  2005

  • Hikikomori, is it a culture-reactive or culture-bound syndrome? Nidotherapy and a clinical vignette from Oman

    N Sakamoto, RG Martin, H Kumano, T Kuboki, S Al-Adawi

    INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE   35 ( 2 ) 191 - 198  2005  [Refereed]

     View Summary

    Hikikomori, a form of acute social withdrawal, is becoming a silent epidemic in Japan. As it has not been reported from other parts of the world, hikikomori fulfills the criteria for "a culture-bound syndrome." We report a case from Oman, in the southern part of Arabia, with all the essential features of hikikomori. We speculate that the social environment of Japanese and Omani society could reinforce behavior akin to hikikomori although this condition may also transcend geography and ethnicity.

  • 心身医療における“証言に基く医療”:文化人類学による質的研究(第2報).

    鈴木勝己, 辻内琢也, 辻内優子, 熊野宏昭, 久保木富房

    心身医学   45 ( 12 ) 907 - 914  2005

  • 過敏性腸症候群を伴うパニック障害患者の臨床的特徴.

    菅谷 渚, 貝谷久宣, 熊野宏昭, 野村 忍

    心身医学   45 ( 12 ) 915 - 922  2005

  • サイコオンコロジーとTA 造血幹細胞移植におけるリエゾンとエゴグラムの活用

    吉内 一浩, 佐々木 直, 坂本 典之, 菊地 裕絵, 冨久尾 航, 熊野 宏昭, 久保木 富房

    交流分析研究   29 ( 2 ) 126 - 131  2004.12

  • チーム医療における心身医学の役割 造血幹細胞移植におけるリエゾン

    吉内 一浩, 佐々木 直, 坂本 典之, 菊地 裕絵, 熊野 宏昭, 久保木 富房

    日本心療内科学会誌   8 ( 4 ) 225 - 228  2004.11

  • Error-related negativity reflects detection of negative reward prediction error

    A Yasuda, A Sato, K Miyawaki, H Kumano, T Kuboki

    NEUROREPORT   15 ( 16 ) 2561 - 2565  2004.11  [Refereed]

     View Summary

    Error-related negativity (ERN) is a negative deflection in the event-related potential elicited in error trials. To examine the function of ERN, we performed an experiment in which two within-participants factors were manipulated: outcome uncertainty and content of feedback. The ERN was largest when participants expected correct feedback but received error feedback. There were significant positive correlations between the ERN amplitude and the rate of response switching in the subsequent trial, and between the ERN amplitude and the trait version score on negative affect scale. These results suggest that ERN reflects detection of a negative reward prediction error and promotes subsequent response switching, and that individuals with high negative affect are hypersensitive to a negative reward prediction error.

  • Power law temporal auto-correlations in day-long records of human physical activity and their alteration with disease

    LAN Amaral, DJB Soares, LR da Silva, LS Lucena, M Saito, H Kumano, N Aoyagi, Y Yamamoto

    EUROPHYSICS LETTERS   66 ( 3 ) 448 - 454  2004.05  [Refereed]

     View Summary

    We investigate long-duration time series of human physical activity under three different conditions: healthy individuals in i) a constant routine protocol and ii) in regular daily routine, and iii) individuals diagnosed with multiple chemical sensitivities. We find that in all cases human physical activity displays power law decaying temporal auto-correlations. Moreover, we find that under regular daily routine, time correlations of physical activity are significantly different during diurnal and nocturnal periods but that no difference exists under constant routine conditions. Finally, we find significantly different auto-correlations for diurnal records of patients with multiple chemical sensitivities.

    DOI

  • Laterality and imbalance of muscle stiffness relate to personality

    Naoki Nakaya, Hiroaki Kumano, Keiji Minoda, Motoyori Kanazawa, Shin Fukudo

    Behavioral Medicine   30 ( 1 ) 5 - 9  2004.03

     View Summary

    The authors' purpose in this study was to test the hypothesis that laterality and imbalance of muscle stiffness relate to personality. The authors selected 23 healthy volunteers and divided them into two groups based on the predominance of muscle stiffness on the left or right side. Imbalance of muscle stiffness was calculated as the absolute value of the difference of muscle stiffness between the right and left sides. The authors evaluated personality with the Japanese version of the Eysenck Personality Questionnaire. Subjects with left predominant muscle stiffness of the rectal abdominis had significantly higher neuroticism score than those with right predominant muscle stiffness. Subjects with more imbalance of muscle stiffness in the latissimus dorsi and in the trapezius had significantly higher neuroticism and psychoticism scores than those with less imbalance. The findings suggest that laterality and imbalance of muscle stiffness relate to personality.

    DOI PubMed

  • Comorbidity of irritable bowel syndrome, panic disorder, and agoraphobia in a Japanese representative sample

    H Kumano, H Kaiya, K Yoshiuchi, G Yamanaka, T Sasaki, T Kuboki

    AMERICAN JOURNAL OF GASTROENTEROLOGY   99 ( 2 ) 370 - 376  2004.02  [Refereed]

     View Summary

    OBJECTIVES: Irritable bowel syndrome (IBS) is considered to be a transcultural functional bowel disorder with high comorbidity and psychiatric disorders; but well-designed epidemiologic studies have never been performed in Japan. The purpose of this study was to establish the prevalence of IBS, together with the comorbiclity rates of panic disorder (PD) and agoraphobia, employing a large-scale survey based on stratified random sampling.
    METHOD: A total of 4,000 subjects aged 20-69 years completed a questionnaire and the results were weighted to ensure representativeness of the Japanese general population. The questionnaire covered key symptoms of IBS, PD, and agoraphobia. The prevalence of IBS and its subtypes was calculated by gender. The comorbidity of PD and agoraphobia with IBS was compared with morbidity in non-IBS subjects; and comorbidity in IBS subjects who had consulted medical practitioners regarding their symptoms and in those who had not was also compared.
    RESULTS: The prevalence of IBS was 6.1% in total. It was significantly higher in females than in males. Diarrhea-predominant IBS was more prevalent in males and constipation-predominant IBS in females. The morbidity rates of PD and agoraphobia were significantly higher in IBS than in non-IBS subjects. Comorbidity did not differ between female and male IBS subjects, while morbidity was significantly higher in female than in male non-IBS subjects; and comorbidity did not differ between consulter and nonconsulter subjects.
    CONCLUSIONS: The prevalence of IBS and its comorbidity with PD and agoraphobia in Japan were demonstrated to be similar to those reported in Western industrialized countries.

    DOI

  • 化学物質過敏症の身体症状・精神症状の出現様式

    齊藤 麻里子, 熊野 宏昭, 吉内 一浩, 小久保 奈緒美, 大橋 恭子, 青柳 直子, 山本 義春, 坂部 貢, 松井 孝子, 篠原 直秀, 柳沢 幸雄, 久保木 富房

    心身医学   44 ( 1 ) 70 - 70  2004.01

  • QT interval and QT dispersion in eating disorders

    Y Takimoto, K Yoshiuchi, H Kumano, G Yamanaka, T Sasaki, H Suematsu, Y Nagakawa, T Kuboki

    PSYCHOTHERAPY AND PSYCHOSOMATICS   73 ( 5 ) 324 - 328  2004  [Refereed]

     View Summary

    Background: Eating disorders are thought to be risk factors for cardiac sudden death secondary to arrhythmia. Results in previous studies on QT interval and QT dispersion, markers of fatal arrhythmia, have been inconsistent. Methods: We prospectively examined 179 female eating disorder patients, being over 18 years old and diagnosed according to the DSM-IV criteria between January 1995 and December 2002, and 52 healthy women. Patients with abnormal plasma electrolytes or taking medications that might influence the electrocardiogram (ECG) were excluded from the study. QT intervals were corrected for heart rate using Bazett's formula and the nomogram method, which is more reliable at extremely low heart rates than Bazett's formula. QT dispersion was measured as the difference between the longest and shortest QT intervals. QT intervals and QT dispersion in each patient group were compared with those in the control group. Results: The 164 eligible patients consisted of 43 patients with anorexia nervosa restricting type, 35 with anorexia nervosa binge eating/purging type, 63 with bulimia nervosa purging type, and 23 with bulimia nervosa nonpurging type. There was no significant difference in age between eating disorder patients and controls. QT interval and QT dispersion were significantly longer in all eating disorder subtypes than in the control group. QT interval and QT dispersion were significantly correlated with the rate of body weight loss in bulimia nervosa. Conclusions: QT interval and QT dispersion were prolonged in both anorexia nervosa and bulimia nervosa. Examination of ECG in eating disorder patients without extremely low body weight also appears to be clinically important. Copyright (C) 2004 S. Karger AG.

    DOI

  • Preliminary study: Psychological effects of muscle relaxation on juvenile delinquents

    N Nakaya, H Kumano, K Minoda, T Koguchi, K Tanouchi, M Kanazawa, S Fukudo

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE   11 ( 3 ) 176 - 180  2004  [Refereed]

     View Summary

    The purpose of this study is to test our hypothesis that muscle relaxation is effective on the psychological well-being of juvenile delinquents. Subjects were 16 juvenile delinquents who had entered a reform school. Subjects were divided into two groups. The muscle relaxation group received muscle relaxation therapy once a week for a total of 4 times. The control group spent an ordinary daily life in the reformatory. Psychological questionnaires used were the Rosenzweig Picture Frustration Study (P-F study), the Psychological Stress Response Scale (PSRS), and the Eysenck Personality Questionnaire (EPQ). There was a significant Group x Time interaction of the Group Conformity Rating (GCR) of the P-F study (F [1, 14] = 10.1, P = 0.007). There were no significant interactions in the other psychological subscales.
    Thus, muscle relaxation therapy may improve frustration tolerance among juvenile delinquents.

  • 東大式社会不安尺度の開発と信頼性・妥当性の検討.

    貝谷久宣, 金井嘉宏, 熊野宏昭, 坂野雄二, 久保木富房

    心身医学   44 ( 4 ) 279 - 287  2004

  • 化学物質過敏症の日常生活中での身体症状・精神症状の評価

    齊藤 麻里子, 熊野 宏昭, 吉内 一浩, 小久保 奈緒美, 大橋 恭子, 青柳 直子, 山本 義春, 坂部 貢, 松井 孝子, 篠原 直秀, 柳沢 幸雄, 久保木 富房

    臨床環境医学   12 ( 2 ) 165 - 165  2003.12

  • Possible variances of blood urea nitrogen, serum potassium and phosphorus levels and interdialytic weight gain accounted for compliance of hemodialysis patients

    J Takaki, T Nishi, H Shimoyama, T Inada, N Matsuyama, T Sasaki, H Kumano, T Kuboki

    JOURNAL OF PSYCHOSOMATIC RESEARCH   55 ( 6 ) 525 - 529  2003.12  [Refereed]

     View Summary

    Objective: The aim of this study was to assess the possible variances of blood urea nitrogen (BUN), serum potassium (SK) and serum phosphorus (SPO4) levels and interdialytic weight gain (IWG) accounted for compliance of uremic patients on hemodialysis (HD). Methods: BUN, SK and SPO4 levels and IWG of uremic patients (n = 310) regularly undergoing three HD sessions per week for more than I year in Japan were assessed. Patients suffering from problems influencing dietary intake and those with malnutrition were excluded. The variances accounted for self-efficacy for health-related behavior and avoidance-oriented coping (AOC) with stress were assessed by hierarchical multiple regression analyses. Results: BUN and SPO4 levels were not significantly (P&lt;.05) associated with self-efficacy or AOC. SK levels and IWG were significantly (P&lt;.05) associated with self-efficacy and/or AOC. The variances of SK levels and IWG accounted for self-efficacy and/or AOC, independent of age, sex, duration of HD and facilities, were 1.6% and 5.0%, respectively. Conclusions: Although the variances of SK levels and IWG accounted for self-efficacy and/or AOC were rather small, the significance of their relationships may suggest that intervention for self-efficacy or AOC could improve compliance and reduce SK levels and IWG of uremic patients on HD. (C) 2003 Elsevier Inc. All rights reserved.

    DOI

  • Clinical worth of adiponectin levels in obesity and glycemic control of Japanese type 2 diabetic patients

    K Nonogaki, H Kumano, Y Ootsuka, A Takeuchi, N Nonogaki

    DIABETES CARE   26 ( 11 ) 3198 - 3198  2003.11  [Refereed]

  • 化学物質過敏症の日常生活中での身体症状・精神症状の評価

    齊藤 麻里子, 熊野 宏昭, 吉内 一浩, 小久保 奈緒美, 大橋 恭子, 青柳 直子, 山本 義春, 坂部 貢, 松井 孝子, 篠原 直秀, 柳沢 幸雄, 久保木 富房

    日本臨床環境医学会総会プログラム・抄録集   12回   72 - 72  2003.06

  • Clinical and psychological aspects of restless legs syndrome in uremic patients on hemodialysis

    J Takaki, T Nishi, M Nangaku, H Shimoyama, T Inada, N Matsuyama, H Kumano, T Kuboki

    AMERICAN JOURNAL OF KIDNEY DISEASES   41 ( 4 ) 833 - 839  2003.04  [Refereed]

     View Summary

    Background: The pathogenesis of restless legs syndrome (RLS) is still unclear. The purpose of this study is to determine relationships of the presence of RLS in uremic patients regularly undergoing hemodialysis (HD) with demographic, clinical, and psychological factors. Methods: In 490 uremic patients on HD therapy in Japan, RLS was diagnosed based on diagnostic criteria established by the International Restless Legs Syndrome Study Group. Data were compared between patients with and without RLS. Results: There were univariately significant (P &lt; 0.05) differences in serum phosphorus levels, anxiety levels determined using the Hospital Anxiety and Depression Scale, and degrees of emotion-oriented and avoidance-oriented coping determined using the Coping Inventory for Stressful Situations. In multivariate, analyses, low hemoglobin levels, high serum phosphorus levels, high anxiety levels, and a great degree of emotion-oriented coping were independently related to the presence of RLS in uremic patients on HD therapy, with statistical significance (P &lt; 0.05). Conclusion : Hyperphosphatemia, anxiety, and a great degree of emotion-oriented coping with stress were independently related to the presence of RLS in uremic patients on HD therapy. The pathogenesis of RLS seems to involve more than one mechanism, which leads to restless legs as the final common pathway. These findings may provide new clues to the pathogenesis of RLS. (C) 2003 by the National Kidney Foundation, Inc.

  • Effects of effort and distress coping processes on psychophysiological and psychological stress responses

    S Suzuki, H Kumano, Y Sakano

    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY   47 ( 2 ) 117 - 128  2003.02  [Refereed]

     View Summary

    The purpose of this study was to investigate the effects of coping processes on psychophysiological and psychological responses in stressful settings. In particular, we focused on the effects of a combination of active and avoidant coping processes. Subjects were 40 healthy undergraduate male students (mean = 19.80, S.D. = 0.97) who were randomly divided into four groups: (a) an effort coping group in which a subject faced a controllable stressor mobilizing an effortful and active coping behavior for a reward; (b) a distress coping group in which a subject faced a distressful stressor mobilizing an avoidant coping behavior for threat of punishment; (c) an effort-distress coping group in which a subject faced an ambivalent stressor mobilizing active coping behavior for a reward and avoidant coping behavior for threat of punishment; and (d) a control group. Initially, the effects of effort coping, distress coping, and effort-distress coping on psychophysiological and psychological responses were investigated. It was found that effort coping and effort-distress coping intensified cardiovascular responses, particularly blood pressure, and that distress coping and effort-distress coping intensified skin conductance level (SCL). Secondarily, the relationships between effort coping process, distress coping process, psychophysiological responses, and psychological responses were investigated. As a result of cluster analysis, the changes of heart rate and blood pressure were correlated to the change of the effort score, and the changes of SCL and psychological responses were correlated to the change of the distress score. These findings suggest that active coping processes and avoidant coping processes independently affect different response systems. (C) 2002 Elsevier Science B.V. All rights reserved.

  • Relations among premorbid weight, referral weight, and psychological test scores for patients with anorexia nervosa

    N Miyasaki, K Yoshiuchi, G Yamanaka, T Sasaki, H Kumano, T Kuboki

    PSYCHOLOGICAL REPORTS   92 ( 1 ) 67 - 74  2003.02  [Refereed]

     View Summary

    The purpose of this study was to test the hypothesis that, in anorexia nervosa, patients with a low premorbid weight are associated with a low weight at referral and that premorbid weight, referral weight, and weight loss are associated with mood states. The changes of Body Mass Index from premorbid to referral, the duration of illness, and the psychological scores on the Profile of Mood States and the Cornell Medical Index-Health Questionnaire were examined in 49 anorexia nervous patients. Body Mass Index at referral of patients with lower premorbid Body Mass Index was significantly lower than that of patients with higher premorbid level. For patients with a larger relative decrease, scores on depressive mood were lower. These findings suggested that in anorexia nervosa patients, lower premorbid Body Mass Index was associated with lower Body Mass Index at referral, and that the patients with higher relative decrease in Body Mass Index might be satisfied with their weight loss.

  • Reliability and validity of a Japanese version of the Eating Disorder Inventory

    M Shimura, H Horie, H Kumano, Y Sakano, H Suematsu

    PSYCHOLOGICAL REPORTS   92 ( 1 ) 131 - 140  2003.02  [Refereed]

     View Summary

    The rapid increase of patients with eating disorders in Japan has made necessary the reliable and valid measurement of psychological factors in eating disorders. The purpose of this study was to examine the reliability and validity of the Japanese version of the Eating Disorder Inventory. 766 females without eating disorders and 139 female patients with eating disorders responded to the Eating Attitude Test and the Eating Disorder Inventory. Principal factor extraction with promax rotation isolated 9 interpretable factors with satisfactory internal consistency (Cronbach alpha range = .74-.90). Compared with controls, patients scored significantly higher on all factors after minimizing the influence of Body Mass Index, There were strong correlations among factor scores and scores on the Eating Attitudes Test, particularly among patients. These results indicate the Eating Disorder Inventory as showing psychometrically sound internal consistency and concurrent validity.

  • Associations and interactions of age, sex, and duration of hemodialysis with compliance in uremic patients

    J Takaki, T Nishi, H Shimoyama, T Inada, N Matsuyama, T Sasaki, H Kumano, T Kuboki

    DIALYSIS & TRANSPLANTATION   32 ( 1 ) 12 - 17  2003.01  [Refereed]

     View Summary

    Purpose. The aim of this study was to assess the relationships of compliance with age, sex, and duration of hemodialysis (HD) simultaneously in a large population of uremic patients on HD.
    Methods. Uremic patients (n = 484) who were regularly undergoing 3 HD sessions/week in Japan were investigated with regard to age, sex, duration of HD, and compliance measures (i.e., blood urea nitrogen [BUN], serum potassium [SK], and serum phosphorus levels [SPO4] levels and interdialytic weight gain [IDWG]). Associations and interactions among them were assessed by correlations and hierarchical multiple regression analyses.
    Results. Older age was significantly associated with low levels of BUN, SPO4, and IDWG (p&lt;0.05), but not with SK levels. Longer duration of HD was significantly associated with high levels of SK, SPO4, and IDWG (p&lt;0.05), but not with BUN levels. The regression lines illustrating significant (p&lt;0.05) interactions predict that in men, the longer the duration of HD, the higher the levels of BUN and SK, and the higher the IDWG; this was not the case in women.
    Conclusions. In uremic patients on HD, compliance was likely to be different based on the patient's sex and duration of HD.

  • High social desirability and prefrontal cortical activity in cancer patients: a preliminary study.

    Tashiro T, Juengling F, Moser E, Reinhardt M, Kubota K, Yanai K, Sasaki H, Nitzsche EU, Kumano H, Itoh M

    Med Sci Monit   9 ( 4 ) CR119 - 124  2003

  • Behavioral power-law exponents in the usage of electric appliances correlate mood states in the elderly.

    Yoshiuchi K, Yamamoto Y, Niwamoto H, Watsuji T, Kumano H, Kuboki T

    International Journal of Sport and Health Sciences   1 ( 1 ) 41 - 47  2003

  • 広場恐怖を伴うパニック障害患者における一般性セルフ・エフィカシー尺度の特徴に関する検討.

    陳峻文, 形岡美穂子, 鈴木伸一, 川村由美子, 熊野宏昭, 貝谷久宣, 坂野雄二

    心身医学   43 ( 12 ) 821 - 828  2003

  • Interactions Among a Stressor, Self-efficacy, Coping with Stress, Depression, and Anxiety in Maintenance Hemodialysis Patients

    Jiro Takaki, Tadahiro Nishi, Hiromi Shimoyama, Toshio Inada, Norimasa Matsuyama, Hiroaki Kumano, Tomifusa Kuboki

    Behavioral Medicine   29 ( 3 ) 107 - 112  2003

     View Summary

    The authors' purpose in this study was to assess the interactive effects of stressors, coping with stress, and self-efficacy on depression and anxiety in maintenance hemodialysis (HD) patients. Patients (n = 453) undergoing HD for more than 1 year in Japan were investigated. The regression lines illustrating significant (p &lt
    .05) interactions predict that itching HD patients with low self-efficacy will be more depressive and anxious than nonitching patients. In HD patients who report a high degree of emotion-oriented coping, itching patients will he more anxious than nonitching patients. These new findings may lead to the development of specific and focused interventions for depression or anxiety in maintenance HD patients. © 2003 Taylor &amp
    Francis Group, LLC.

    DOI PubMed

  • Application of Quick Environment Exposure Sensitivity Inventory (QEESI (c)) for Japanese population: study of reliability and validity of the questionnaire

    S Hojo, H Kumano, H Yoshino, K Kakuta, S Ishikawa

    TOXICOLOGY AND INDUSTRIAL HEALTH   19 ( 2-6 ) 41 - 49  2003  [Refereed]

     View Summary

    A standardized questionnaire has not been established for screening or diagnostic assessment of patients with multiple chemical sensitivity (MCS) in Japan. In the US, Miller and Prihoda (1999a,b) developed a questionnaire that could be used internationally, the Quick Environment Exposure Sensitivity Inventory (QEESI(C)), to assist researchers and clinicians in evaluating patients and populations for chemical sensitivity. The Japanese version of QEESI(C) was subsequently translated by Ishikawa and Miyata (1999). The present study was performed to investigate the reliability and validity of QEESI(C) ( Japanese version) for research purposes and for evaluation of patients with MCS in Japan.
    A total of 498 subjects were recruited from the general population of Miyagi prefecture, Japan. The factor structure in QEESI(C) was analyzed with 40 items on four subscales except for the items in 'Masking' using principal components analysis with Promax rotation. The results showed that 30 items on three subscales, 'Chemical Inhalant Intolerances,' 'Symptom Severity,' and 'Life Impact' except for 'Other Intolerances' were consistent with those reported for the US population by Miller and Prihoda (1999a). Cronbach's alpha reliability coefficient ranged between 0.87 and 0.94 indicating high internal consistency in the 30 items on three subscales.
    Next, we compared the mean scores on three subscales of QEESI(C) in two groups: 131 self-reported MCS group who were new outpatients at the Environmental Medical Center in Kitasato Institute Hospital, and 131 members of the general population ( controls) who were matched for both gender and age with the self-reported MCS group. Mean scores on each subscale for the self-reported MCS group were significantly greater than those for controls (P&lt;0.001). Mean scores on all of the 30 items on three subscales for the self-reported MCS group were also significantly greater than for the controls (P&lt;0.001). These findings indicated that the 30 items on three subscales in QEESI(C) can be used for surveys and for diagnostic assessment of patients with MCS as well as for comparative studies between patients in Japan and in other countries.

    DOI

  • Multiple Chemical Sensitivityの日常生活中での評価 Ecological Momentary Assessment(EMA)の手法を用いて

    齊藤 麻里子, 熊野 宏昭, 吉内 一浩, 小久保 奈緒美, 大橋 恭子, 青柳 直子, 山本 義春, 坂部 貢, 松井 孝子, 篠原 直秀, 柳沢 幸雄, 久保木 富房

    臨床環境医学   11 ( 2 ) 123 - 123  2002.12

  • Relationship of health status and social support to the life satisfaction of older adults

    CW Wang, T Iwaya, H Kumano, Y Suzukamo, Y Tobimatsu, S Fukudo

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   198 ( 3 ) 141 - 149  2002.11  [Refereed]

     View Summary

    We examined the relationship of health factors and social support to life satisfaction in older adults dwelling in a rural town. The gender difference in variables related to life satisfaction was also discussed in this study. One hundred and forty-two older adults (86 females and 56 males) who completed a self-administered questionnaire and participated in a health examination in 1998 or 1999 comprised the study participants. The t-test and chi-square test were used to assess the differences between the two genders. Correlation measure and multiple regression analysis were used to assess the relationship between life satisfaction and other health related or socially related factors for each gender. Significant gender differences were observed in living status and several health related factors. According to the results of the multiple regression analyses, life satisfaction was related to mental health and age in females, while it was related to mental health status and social support from others in males. Gender differences in the variables associated with life satisfaction were observed among the community-dwelling older adults. These data suggest the importance of mental health for older adults. When preparing health promotion strategies for older adults, results of gender differences as they related to social support and life satisfaction should be applied in practice.

  • Multiple Chemical Sensitivityの日常生活中での評価 Ecological Momentary Assessment(EMA)の手法を用いて

    齊藤 麻里子, 熊野 宏昭, 吉内 一浩, 小久保 奈緒美, 大橋 恭子, 青柳 直子, 山本 義春, 坂部 貢, 松井 孝子, 篠原 直秀, 柳沢 幸雄, 久保木 富房

    日本臨床環境医学会総会プログラム・抄録集   11回   48 - 48  2002.07

  • Relationship between somatosensory amplification and alexithymia in a Japanese psychosomatic clinic

    M Nakao, AJ Barsky, H Kumano, T Kuboki

    PSYCHOSOMATICS   43 ( 1 ) 55 - 60  2002.01  [Refereed]

     View Summary

    To examine the relationship between somatosensory amplification and three factors of alexithymia (difficulty identifying feelings, difficulty describing feelings, and externally oriented thinking), 48 outpatients attending a Japanese psychosomatic clinic and 33 comparative outpatients completed the Somatosensory Amplification Scale (SSAS), 20-item Toronto Alexithymia Scale (TAS-20), Profile of Mood States (POMS), and other self-rating questionnaires. The scores on the SSAS and the first and second TAS-20 factors were higher (all P&lt;0.001) in the psychosomatic group than in the comparison group. The SSAS was positively associated (both P&lt;0.01) with these two TAS-20 factors, controlling for the effects of age, sex, group, and POMS tension-anxiety and depression. Somatosensory amplification appears to be associated with difficulties identifying and describing feelings, not externally oriented thinking, in Japanese patients.

  • The effect of Qi-Gong relaxation exercise on the control of type 2 diabetes mellitus

    T Tsujiuchi, H Kumano, K Yoshiuchi, DG He, Y Tsujiuchi, T Kuboki, H Suematsu, K Hirao

    DIABETES CARE   25 ( 1 ) 241 - 242  2002.01  [Refereed]

  • 化学物質過敏症における心身医学的検討.

    辻内優子, 熊野宏昭, 吉内一浩, 辻内琢也, 中尾睦宏, 久保木富房, 岡野禎治

    心身医学   42 ( 3 ) 206 - 216  2002

  • 心療内科入院治療を施行した不登校症例の病態特徴について-DSM(Ⅲ-R&amp;Ⅳ)多軸評定に準じた形式での評定結果より-.

    古口高志, 山内祐一, 熊野宏昭

    心身医学   42 ( 7 ) 468 - 474  2002

  • 反抗挑戦性障害(ODD)を併存した注意欠陥/多動性障害(ADHD)に対し家族療法と薬物療法を併用し改善した1例.

    齊藤麻里子, 佐々木直, 熊野宏昭, 竹内俊明, 福島一成, 佐藤亜貴子, 児玉真澄, 牛田洋一, 長谷川啓三, 久保木富房

    心療内科   6 ( 3 ) 210 - 216  2002

  • 心療内科および神経科プライマリーケア施設における認知行動療法適用の実際.

    大塚明子, 形岡美穂子, 村中泰子, 川村有美子, 鈴木伸一, 熊野宏昭

    行動療法研究   28   15 - 24  2002

  • Short Interpersonal Reactions Inventory日本語短縮版(SIRI33)によるタイプC測定に関する弁別的妥当性の検討.

    熊野宏昭, 久保木富房, 織井優貴子, 福瀬達郎, 平田敏樹, 篠原一彦, 瀬戸正弘, 上里一郎, 坂野雄二

    心身医学   41 ( 8 ) 593 - 599  2001.12

  • Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients: A preliminary pet study

    M Tashiro, M Itoh, K Kubota, H Kumano, MM Masud, E Moser, H Arai, H Sasaki

    PSYCHO-ONCOLOGY   10 ( 6 ) 541 - 546  2001.11  [Refereed]

     View Summary

    The purpose of this study is to examine the relationship between psychological factors, regional brain activity and natural killer cell activity (NTKA). Eight patients with malignant diseases were studied by FDG-PET under a resting condition. NKA and degree of anxiety and depression were measured using Taylor's manifest anxiety scale (MAS) and Zung's self-rating depression scale (SDS). Linear correlation of NKA and psychological measures to the regional brain metabolism in cancer patients was examined using statistical parametric mapping (SPM).
    Positive linear correlation between NKA and regional metabolic rate ratios was identified in the visual association cortex, anterior cingulate gyrus (CG) and sensorimotor area, and negative correlation was identified in the inferolateral prefrontal cortex (ILPFC), prefrontal cortex (PFC), orbitofrontal cortex (OFC) and anterior temporal cortex. Positive linear correlation to the MAS score was identified in the visual association cortex, anterior CG, primary sensorimotor area and the posterior parietal cortex, and negative correlation was detected in the ILPFC, PFC, OFC and anterior temporal cortex. The NKA and MAS scores positively correlated with each other (p &lt; 0.001).
    The result might serve as supporting data for a hypothesis that psycho-immune interaction is also mediated by the cerebral cortex and limbic system. Copyright (C) 2001 John Wiley & Sons, Ltd.

  • 催吐剤(ipecac)により筋力低下をきたしたと考えられる摂食障害の1例

    長谷目 悦子, 山中 学, 吉内 一浩, 佐々木 直, 熊野 宏昭, 久保木 富房, 櫛山 暁史, 永谷 勝也, 佐藤 健夫, 磯部 秀之

    心身医学   41 ( 7 ) 571 - 571  2001.10

  • Tashiro M, Juengling FD, Reinhardt MJ, Mix M, Kumano H, Kubota K, Itoh M, Sasaki H, Nitzsche EU, Moser E

    Depressive state, regional cerebral activity in cancer, patients - a preliminary study

    Med Sci Monit   7 ( 4 ) 687 - 695  2001

  • 摂食障害のサブタイプにおける認知的障害の程度は同じか?-認知行動理論からの検討-.

    松本聰子, 佐々木直, 熊野宏昭, 久保木富房, 野村忍, 坂野雄二, 成尾鉄朗, 野添信一

    心身医学   41 ( 7 ) 530 - 537  2001

  • 身体感覚増幅尺度日本語版の信頼性・妥当性の検討-心身症患者への臨床的応用について-.

    中尾睦宏, 熊野宏昭, 久保木富房, Barsky AJ

    心身医学   41 ( 7 ) 540 - 547  2001

  • 中学生の自殺親和状態尺度作成の試み.

    大塚明子, 熊野宏昭, 瀬戸正弘, 上里一郎

    カウンセリング研究   34 ( 1 ) 21 - 30  2001

  • Lateralization of the relationship between changes in NK activity and the change in the alpha wave.

    Kamei T, Hata K, Toriumi Y, Otani H, Kumano H, Jimbo S

    Photomedicine and Photobiology   23   85 - 91  2001

  • 外傷体験後、予期不安からパニック発作を繰り返してきた広場恐怖患者の認知行動療法.

    大塚明子, 熊野宏昭

    行動療法研究   27   83 - 96  2001

  • 視覚障害への心理的適応を測定する尺度 The Nottingham Adjustment Scale 日本語版の開発.

    鈴鴨よしみ, 熊野宏昭, 岩谷力

    心身医学   41 ( 8 ) 609 - 618  2001

  • The effect of a traditional Chinese prescription for a case of lung carcinoma

    T Kamei, H Kumano, K Iwata, Y Nariai, T Matsumoto

    JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE   6 ( 6 ) 557 - 559  2000.12  [Refereed]

     View Summary

    Objective: To examine the effectiveness of Ninjin Yoei To (NYT; Ren-Shen-Yang-Rong-Tang in Chinese medicine; Kotaro Pharmaceutical Co., Ltd., Osaka, Japan), one of the traditional herbal medicines, against lung carcinoma.
    Setting: The Nursing Center Himawari
    Design, Patient, and Preparation: The regular dosage of NYT (15g/d) was prescribed for 7 weeks to one elderly patient with lung carcinoma. The daily standard dose of NYT is prepared from dried extract obtained from 12 crude natural substances, ginseng, cinnamon bark, Japanese angelica root, astragalus root, peony root, citrus unshiu peel, rehmannia root, polygala root, atractylodes rhizome, schisanda fruit, poria sclerotium, and glycyrrhiza. NYT is certified by the Japanese Ministry of Health and Welfare.
    Results: The tumor marker levels (CEA and CA19-9) decreased and the scores of yin-yang and xu-shi inverted from negative and positive during 7 weeks. The patient's cough disappeared and her appetite recovered.
    Conclusion: NYT has a positive effect on life expectancy for patients with malignancy. The diagnostic scoring system in yin-yang and xu-shi and prescription of Chinese herb may be available to gain control over a patient's health.

  • Short Interpersonal Reactions Inventory日本語短縮版作成の試み(第2報)-33項目版への改定.

    熊野宏昭, 織井優貴子, 山内祐一, 瀬戸正弘, 上里一郎, 坂野雄二, 宗像正徳, 吉永馨, 佐々木直, 久保木富房

    心身医学   40 ( 6 ) 447 - 454  2000.08

  • Decrease in serum cortisol during yoga exercise is correlated with alpha wave activation

    T Kamei, Y Torui, H Kimura, S Ohno, H Kumano, K Kimura

    PERCEPTUAL AND MOTOR SKILLS   90 ( 3 ) 1027 - 1032  2000.06  [Refereed]

     View Summary

    We examined changes in brain waves and blood levels of serum cortisol during yoga exercise in 7 yoga instructors and found that alpha waves increased and serum cortisol decreased. These two measures were negatively correlated (r = -.83). Comparison with a control group of nonpractitioners is desirable.

  • Improvement of C-reactive protein levels and body temperature of an elderly patient infected with Pseudomonas aeruginosa on treatment with Mao-Bushi-Saishin-To

    T Kamei, T Kondoh, S Nagura, Y Toriumi, H Kumano, H Tomioka

    JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE   6 ( 3 ) 235 - 239  2000.06  [Refereed]

     View Summary

    Objective: To examine the effectiveness of Mao-bushi-saishin-to (Ma-Huang-Fu-Zi-Xi-Xin-Tang in Chinese medicine) (Tochimototenkaido Co, Ltd., Osaka, Japan), one of the traditional herbal medicines, against resistant bacterial infection.
    Setting: The Nursing Center Himawari, Izumo, Japan
    Design, patient, and preparation: Half of the standard dose of Mao-bushi-saishin-to was prescribed for 7 days to one elderly patient with fever and positive C-reactive protein (CRP) levels suffering from drug resistant Pseudomonas aeruginosa. The daily standard dose of Mao-bushisaishin-to is prepared from 1200 mg of dried extract obtained from three crude drugs, Ephedrae Herba (4 g), Asiasari Radix (3 g), and Aconiti Tuber (1 g). It is certified by the Japanese Ministry of Health and Welfare.
    Results: The patient's fever and CRP level returned to normal levels.
    Conclusions: In cases in which the fever does not fall in response to antibiotics for at least 3 days, half of the standard dose of Mao-bushi-saishin-to for 7 days might be worth trying to induce remission, especially for elder patients.

  • Use of photic feedback as an adjunct treatment in a case of Miller Fisher syndrome

    T Kamei, Y Toriumi, H Kumano, M Fukada, T Matsumoto

    PERCEPTUAL AND MOTOR SKILLS   90 ( 1 ) 262 - 264  2000.02  [Refereed]

     View Summary

    Photic Feedback treatment of a patient diagnosed with Miller Fisher syndrome has resulted in the rapid and permanent remission of symptoms. During Photic Feedback treatment, the CD20 appeared to be slighty increased. This map have been associated with changes in humoral immunity. The present clinical observation of a single patient suggests that Photic Feedback treatment should be investigated as a possible adjunct therapy for patients who suffer from polyneuropathies, such as Miller Fisher syndrome. within a carefully controlled clinical trial.

  • Effect of half the standard dose of Mao-bushi-saishin-to in two MRSA patients and one decubitus ulcer patient

    T Kamei, S Nagura, Y Toriumi, H Kumano, T Kondoh, H Tomioka

    AMERICAN JOURNAL OF CHINESE MEDICINE   28 ( 2 ) 301 - 304  2000  [Refereed]

  • 転換性障害を合併した難治性喘息の1例.

    境洋二郎, 江花昭一, 川原健資, 山本晴義, 津久井要, 桂戴作, 熊野宏昭, 久保木富房

    心療内科   4   363 - 367  2000

  • 赤光発光ダイオード光の前頭部への照射が末梢血中のナチュラルキラー細胞に与える効果.

    亀井勉, 鳥海善貴, 熊野宏昭, 大谷浩, 安土光男, 柳平雅俊, 神保聖一

    照明学会誌   84 ( 11 ) 851 - 854  2000

  • 服薬コンプライアンス尺度(第1報)-服薬コンプライアンス尺度の作成.

    平塚祥子, 熊野宏昭, 片山潤, 岸川幸生, 菱沼隆則, 山内祐一, 水柿道直

    薬学雑誌   120   224 - 229  2000

  • 服薬コンプライアンス尺度(第2報)-心療内科における服薬コンプライアンスに関わる諸要因.

    平塚祥子, 熊野宏昭, 片山潤, 岸川幸生, 菱沼隆則, 山内祐一, 水柿道直

    薬学雑誌   120   224 - 229  2000

  • Psychosocial factors associated with peptic ulcer in aged persons

    M Furuse, H Kumano, K Yoshiuchi, Y Yamauchi

    PSYCHOLOGICAL REPORTS   85 ( 3 ) 761 - 769  1999.12  [Refereed]

     View Summary

    The relationship between psychosocial factors and the occurrence and aggravation of peptic ulcer was studied in elderly people. Thirty-nine (14 male) ulcer patients and 79 (30 male) elderly people aged 65 years and over and living in the community were tested. Information on health status, medication, lifestyle, and psychosocial status was obtained by means of interviews using a questionnaire and from the clinical records of the ulcer patients. The same questionnaire was distributed to the residents. Logistic regression analysis adjusting for age disclosed that peptic ulcer was significantly associated with having an occupation and low exercise practice in men. However, the relationship weakened below statistical significance after adjusting for some physical risk factors besides age Low education was significant but low instrumental support fell short of statistical significance with peptic ulcer in women even after adjustment for several physical risk factors besides age. Thus, the specific psychosocial factors might be independently associated with the occurrence and aggravation of peptic ulcer in at least elderly women.

  • Short Interpersonal Reactions Inventory日本語短縮版作成の試み-タイプCパーソナリティ測定を中心として.

    熊野宏昭, 織井優貴子, 鈴鴨よしみ, 山内祐一, 宗像正徳, 吉永馨, 瀬戸正弘, 坂野雄二, 上里一郎, 久保木富房

    心身医学   39 ( 5 ) 335 - 341  1999.06

  • Assessment of ego state in anorexia nervosa and bulimia nervosa

    M Nakao, H Kumano, S Nomura, T Kuboki, K Murata

    ACTA PSYCHIATRICA SCANDINAVICA   99 ( 5 ) 385 - 387  1999.05  [Refereed]

     View Summary

    To clarify the effects of ego states on anorexia nervosa (AN) and bulimia nervosa (BN), the questionnaire of the Tokyo University Egogram (TEG) with critical parent, nurturing parent, adult, free child and adapted child scales was administered to 32 female AN patients aged 14 to 32 years (mean age 20 years) and 49 female BN patients aged 14 to 33 years (mean age 23 years). The scores on the critical parent and adapted child scales for AN were significantly lower than those for BN, A multiple logistic regression analysis including all of the TEG scales, age, duration of illness and education showed that the adapted child scale significantly discriminated between AN and BN. The adaptive ego state is suggested for differentiating between the two disorders.

  • Age-related bone loss: Relationship between age and regional bone mineral density

    T Kamei, K Aoyagi, T Matsumoto, Y Ishida, K Iwata, H Kumano, Y Murakami, Y Kato

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   187 ( 2 ) 141 - 147  1999.02  [Refereed]

     View Summary

    We assessed the changes in regional bone mineral density according to age and examined the relationship between various regional bone mineral densities. The study was conducted in 985 Japanese women divided into &lt; 50-years group (n = 435) and greater than or equal to 50 years group (n=550). The total body bone mineral density and that of the head, arm, leg, thoracic (T)-spine, lumbar (L)-spine, ribs, and pelvis were measured using dual energy x-ray absorptiometry. There was a significant generalized reduction of bone mineral density in all regions after the age of 50 years. The most marked age-related decrease was observed in the L-spine. Bone mineral densities in all regions significantly correlated to each other in both age groups, but the degree of significance varied among regions. The relationship between bone mineral density of the L-spine and that of T-spine regions was the most significant in both groups. In the &lt;50-years group, the correlation between bone mineral density of the pelvis and that of L-spine and T-spine was the highest, followed by that between the pelvis and the leg. On the ether hand, in the greater than or equal to 50-years group, the correlation between bone mineral density of the pelvis and that of the leg was the highest, but not the L-spine of T-spine. Since spine measurements are affected by vertebral deformity and/or aortic calcification, our findings suggest the pelvis may be a useful region for screening measurements of bone mineral density, especially in older women.

  • 在宅介護者のHealth Related QOLの測定.

    古瀬みどり, 鈴鴨よしみ, 熊野宏昭

    看護研究   32   483 - 488  1999

  • Investigation of social influence on eating disorder tendencies and behavior among female students.

    Matsumoto M, Kumano H, Sakano Y

    Japanese Journal of Behavior Therapy   25   11 - 23  1999

  • 前頭部α波パルス光同調反応のnatural killer細胞への効果-脳腫瘍術後患者2例での検討.

    亀井勉, 山崎俊樹, 熊野宏昭, 森竹浩三

    神経免疫研究   12   45 - 51  1999

  • Influences of long- and short-distance driving on alpha waves and natural killer cell activity

    T Kamei, H Kumano, K Iwata, M Yasushi

    PERCEPTUAL AND MOTOR SKILLS   87 ( 3 ) 1419 - 1423  1998.12  [Refereed]

     View Summary

    We examined the effective amplitudes of alpha waves (using a mean frequency with a range of +/- 0.5 Hz), and activity of natural killer cells in six subjects, before and after a short-distance (43 km, 1 hr.) drive, and after a midnight (am 0:00 similar to am 7:00 to 8:00) long-distance (550 km on average, for 7 to 8 hr.) drive. Following a long-distance drive, the activity of natural killer cells tended to decrease, and the effective amplitudes of alpha waves in the photic feedback period were greater than those observed during the rest period, showing that photic driving had occurred even under physically and mentally stressful conditions. However, after short-distance driving, no photic driving response occurred and activity of natural killer cells tended to increase, possibly related to mental concentration. Avoiding midnight long-distance driving may help prevent excessive stress and preserve high activity in natural killer cells.

  • Psychosocial factors influencing the short-term outcome of antithyroid drug therapy in Graves' disease

    K Yoshiuchi, H Kumano, S Nomura, H Yoshimura, K Ito, Y Kanaji, T Kuboki, H Suematsu

    PSYCHOSOMATIC MEDICINE   60 ( 5 ) 592 - 596  1998.09  [Refereed]

     View Summary

    Objective: Although psychological stress and smoking have been proposed as factors contributing to Graves' disease, their independent roles in the course of this disease have not been determined. We assessed the association between the course of Graves' disease and psychosocial factors by using multivariate analysis. Methods: We investigated the association between the short-term outcome of Graves' disease (assessed 12 months after the beginning of antithyroid drug therapy) and stressful life events, daily hassles, smoking, drinking habits, coping skills, and social support (before and 6 months after beginning therapy) in 230 patients (182 women and 48 men) with newly diagnosed Graves' disease, using a logistic regression model. Results: After adjustment for smoking, coping skills, and thyroid function, daily hassles scores in women at 6 months after beginning therapy were significantly associated with a hyperthyroid state 12 months after beginning therapy. The relative risk was 3.9 for women with higher daily hassles scores compared with women with lower daily hassles scores (95% confidence interval, 1.1 to 13.2; p &lt;.05). Smoking was not significantly associated with a hyperthyroid state 12 months after beginning therapy in either women or men. Conclusions: Chronic psychological stress is associated with the course of Graves' disease in women.

  • Fatigue mood as an indicator discriminating between anorexia nervosa and bulimia nervosa

    M Nakao, H Kumano, S Nomura, T Kuboki, K Yokoyama, K Murata

    ACTA PSYCHIATRICA SCANDINAVICA   97 ( 3 ) 202 - 205  1998.03  [Refereed]

     View Summary

    In order to clarify the differences in mood states between anorexia and bulimia nervosa, the Profile of Mood States (POMS) with tension-anxiety, depression, anger-hostility, vigour, fatigue and confusion scales was administered to 32 female patients with anorexia nervosa (age range 14 to 32 years, mean age 20 years), 49 female patients with bulimia nervosa (age range 15 to 33 years, mean age 23 years) and 410 &apos;normal&apos; female subjects (age range 14 to 35 years, mean age 23 years). The scores on the depression, fatigue and confusion scales for both anorexia and bulimia nervosa and those on the tension-anxiety and anger-hostility scales for bulimia nervosa were significantly higher tt;an those for the control subjects. The score on the fatigue scale for bulimia nervosa was significantly higher than that for anorexia nervosa. Moreover, the result of the multiple logistic regression analysis including all of the POMS scales indicated that the fatigue scale significantly discriminated between the two disorders, Fatigue mood appears to be a principal indicator for differentiating between the two disorders.

  • Stressful life events and smoking were associated with Graves' disease in women, but not in men

    K Yoshiuchi, H Kumano, S Nomura, H Yoshimura, K Ito, Y Kanaji, Y Ohashi, T Kuboki, H Suematsu

    PSYCHOSOMATIC MEDICINE   60 ( 2 ) 182 - 185  1998.03  [Refereed]

     View Summary

    Objective: Although psychological stress and smoking have been proposed as contributing factors to Graves' disease, their independent roles in the pathogenesis of this disease have not been determined. We assessed the association between Graves' disease and psychological stress and smoking by using multivariate analysis. Methods: By a matched case-control method, we investigated the association between Graves' disease and stressful life events, daily hassles, smoking, drinking habits, coping skills, and social support in 228 patients (182 women and 46 men) with newly diagnosed Graves' disease; we used the conditional maximum likelihood method. Results: After data were adjusted for daily hassles, smoking, drinking habits, social support, and coping skills, we found that stressful life events were significantly associated with the risk of Graves' disease in women. The relative risk was 7.7 for women with the highest stress score compared with women with the lowest stress score (95% confidence interval, 2.2 to 27, p for trend &lt;.001). Smoking was also independently associated with the risk of Graves' disease in women. The relative risk for women with the highest number group compared with women with the lowest number group for smoking cigarettes was 5.1 (95% confidence interval, 1.0 to 27; p for trend &lt;.001). These factors were not significantly associated with Graves' disease in men. Conclusions: Psychological stress and smoking were associated with Graves' disease in women, but not in men.

  • 心身症と神経症の臨床的特徴-DSM-Ⅲ-Rによる検討-.

    中尾睦宏, 野村忍, 熊野宏昭, 山中学, 久保木富房

    心身医学   38 ( 1 ) 47 - 54  1998

  • ロールシャッハ・テストによる摂食障害患者の臨床像の特徴についての考察.

    原田眞理, 熊野宏昭, 野村忍, 久保木富房, 末松弘行

    心身医学   38 ( 2 ) 143 - 152  1998

  • Assessment of patients by DSM-III-R and DSM-IV in a Japanese psychosomatic clinic

    M Nakao, S Nomura, G Yamanaka, H Kumano, T Kuboki

    PSYCHOTHERAPY AND PSYCHOSOMATICS   67 ( 1 ) 43 - 49  1998.01  [Refereed]

     View Summary

    Background: The aim of this study was to investigate the clinical features of psychosomatic disorders in Japan. Methods: A total of 1,432 outpatients (515 males and 917 females; 9-95 years of age, mean age 36) attending a psychosomatic clinic for the first time were assessed by the DSM-III-R or DSM-IV semistructured interview, Results: Major ICD-10 diagnoses found were eating disorder, other anxiety disorders, autonomic nervous dysfunction, somatoform disorders, and irritable bowel syndrome. The most frequent diagnosis on the DSM-III-R and DSM-IV axis I was 'somatoform disorders not otherwise specified', followed by bulimia nervosa,'depressive disorder not otherwise specified', anorexia nervosa, conversion disorder, major depression or depressive disorder,'panic disorder with agoraphobia', and 'psychological factors affecting physical or medical condition'. On axis II, 11-17% of the patients met the criteria for personality disorder. On axis IV, 78-80% had mild or moderate psychosocial stress; major psychosocial and environmental problems classified by the DSM-IV were the problems with primary supports and occupation. Conclusions: The results seem to reinforce the belief that the diagnoses on the DSM-III-R and DSM-IV axis I are inadequate for describing psychosomatic phenomena. A new diagnostic system in combination with the multidimensional assessments by the DSM-III-R and DSM-IV is needed to form the common guidelines of diagnoses and therapies in psychosomatic medicine.

  • Response of healthy individuals to Ninjin-Yoei-To extract - Enhancement of natural killer cell activity

    T Kamei, H Kumano, K Beppu, K Iwata, S Masumura

    AMERICAN JOURNAL OF CHINESE MEDICINE   26 ( 1 ) 91 - 95  1998  [Refereed]

     View Summary

    After administering 15 g/day of Ninjin-Yoei-To (NYT) for one week to healthy people whose NK activity had already been increased by physiological response, a further increase in NK activity was observed after two days. This increased level of NK activity continued during the administration of NYT for a one-week period. The maintaining and reinforcing effect on the immune surveillance system by NYT may be useful for prevention of carcinogenesis.

  • Autonomic Nervous Functions and Psycho-behavioral Factors on Genesis of White Coat Hypertension.

    Hiraizumi T, Kumano H, Munakata M, Yoshinaga K, Taguchi F, Yamauchi Y

    Japanese Journal of Psychosomatic Medicine   38 ( 6 ) 397 - 405  1998

  • スポーツ傷害発生における身体的・心理社会的要因について-ACL損傷の2症例-.

    小西由里子, 山本利春, 有馬三郎, 熊野宏昭, 山内祐一

    アスレティック・リハビリテーション   1 ( 1 ) 45 - 51  1998

  • ストレス対処過程におけるEffort、Distress次元が心理・生理的反応に及ぼす影響.

    鈴木伸一, 熊野宏昭, 坂野雄二

    心身医学   38   597 - 605  1998

  • 接触加熱型痛覚閾値測定システムによる慢性疼痛の評価.

    山口真人, 青山宏, 山内祐一, 水谷好成, 山本光璋, 田口文人, 熊野宏昭

    慢性疼痛   17 ( 1 ) 45 - 48  1998

  • SF-MPQからみた慢性疼痛の鑑別診断.

    青山宏, 山口真人, 熊野宏昭, 山内祐一, 田口文人

    慢性疼痛   17   72 - 75  1998

  • 高齢のOFLX耐性の感染症3例にみられた1/2服用量の麻黄附子細辛湯投与によるCRP値改善と解熱.

    亀井 勉, 鳥海善貴, 名倉 智, 熊野宏昭, 冨岡治明

    和漢医薬学雑誌   15   462 - 463  1998

  • 嫌悪状況下の心理的,生理的反応に及ぼす対処行動の効果.

    鈴木伸一, 熊野宏昭, 坂野雄二

    行動療法研究   24   85 - 97  1998

  • EEG-driven photic stimulation effect on plasma cortisol and beta-endorphin

    H Kumano, H Horie, T Kuboki, H Suematsu, H Sato, M Yasushi, T Kamei, S Masumura

    APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK   22 ( 3 ) 193 - 208  1997.09  [Refereed]

     View Summary

    The effect of EEG-driven photic stimulation on stress-related endocrine function was studied. Subjects were 16 healthy males divided into a photic stimulation group (n=8) and a control group (n=8). Electrodermal and emotional lability measures were assessed by nonspecific skin conductance response and the Maudsley Personality Inventory, respectively Plasma cortisol and beta-endorphin concentrations were measured both before and after EEG-driven photic stimulation as well as the resting condition. Subjects with electrodermal, emotional or both lability showed comparable decreases of plasma beta-endorphin on photic stimulation as did the stable subjects. Under resting control conditions, however they showed significant increases of beta-endorphin compared to both stable subjects as well as the photic stimulation condition. In addition, labile subjects showed significant alpha enhancement on photic stimulation compared to stable subjects and to the resting control condition. The data suggest that increases of plasma beta-endorphin in labile control subjects may denote a stress response to the conditions of these experiments, and that any decrease by EEG-driven photic stimulation may indicate a reduction of responsiveness to an acute stress.

  • Changes of immunoregulatory cells associated with psychological stress and humor

    T Kamei, H Kumano, S Masumura

    PERCEPTUAL AND MOTOR SKILLS   84 ( 3 ) 1296 - 1298  1997.06  [Refereed]

     View Summary

    For 8 medical students influences of psychological stress or humor on T-cell subset percentages and natural killer cell activity were investigated by measuring these parameters before and after an examination and before and after watching a comedy video. Although T-cell subsets were nor significantly affected by either stimulus and natural killer cell activity was not affected by the examination. the latter was significantly decreased after watching the comedy video.

  • Clinical effects of blood pressure biofeedback treatment on hypertension by auto-shaping

    M Nakao, S Nomura, T Shimosawa, K Yoshiuchi, H Kumano, T Kuboki, H Suematsu, T Fujita

    PSYCHOSOMATIC MEDICINE   59 ( 3 ) 331 - 338  1997.05  [Refereed]

     View Summary

    Although biofeedback has been reported to be efficacious in the treatment of hypertension, the degree of response has varied. :This study investigated the mechanisms of blood pressure reduction by biofeedback. Method: Thirty outpatients with essential hypertension (10 men and 20 women) aged 38 to 65 years were studied. Subjects were randomly assigned to group A or B. Subjects in group A underwent biofeedback treatment once a week for a total of four sessions. Those in group B self-monitored their blood pressure during the sessions as the control period and later underwent the same biofeedback treatment. Results: Blood pressure measured by doctor was reduced by 17 +/- 18/8 +/- 7 (p &lt; .01) and elevation of pressure induced by mental stress testing was suppressed by 8 +/- 9 (p &lt; .05)/4 +/- 8 during the treatment period in group A (mm Hg). In group B, both blood pressure measured by doctor and elevation of pressure by mental stress testing remained unchanged during the control period and they were later suppressed by 20 +/- 15/9 +/- 7 (p &lt; .01) and 11 +/- 10 (p &lt; .05)/5 +/- 9 by the biofeedback treatment. Self-monitored pressure in both groups tended to decrease by the biofeedback treatment. Systolic and diastolic pressures as well as pulse rate decreased, skin temperature increased, and alpha-wave amplitude on electroencephalography increased during the therapy (p &lt; .05). Conclusion: This treatment,Nas effective in suppressing the presser response to stress. Patients whose blood pressure increases with stress may be suited for biofeedback intervention.

  • Hemodynamic and endocrine responsiveness to mental arithmetic task and mirror drawing test in patients with essential hypertension

    K Yoshiuchi, S Nomura, K Ando, T Ohtake, T Shimosawa, H Kumano, T Kuboki, H Suematsu, T Fujita

    AMERICAN JOURNAL OF HYPERTENSION   10 ( 3 ) 243 - 249  1997.03  [Refereed]

     View Summary

    To evaluate the reactivity to psychological stress in patients with essential hypertension we investigated hemodynamic and endocrinologic changes during a mental arithmetic task (MAT) and a mirror drawing test (MDT) in 10 hypertensive subjects. Hemodynamic changes were assessed continuously using an ambulatory radionuclide cardiac detector. There were significant increases in systolic blood pressure (Delta SBP: +37.8 +/- 11.1 and +41.0 +/- 9.4 mm Hg during MAT and MDT, respectively, P &lt; .01) and diastolic blood pressure (Delta DBP: +17.5 +/- 3.1 and +21.2 +/- 3.9 mm Hg, P &lt; .01) and in heart rate (Delta HR: +17.1 +/- 5.3 and +12.5 +/- 2.9 beats/min, P &lt; .01) during both tasks in association with an increase in cardiac output (GO). The plasma levels of norepinephrine and epinephrine increased during both the MAT (Delta NE: +0.074 +/- 0.022 ng/mL, P &lt; .01; Delta EP: +0.068 +/- 0.025 ng/mL, P &lt; .01) and the MDT (Delta NE: +0.067 +/- 0.034 ng/mL, P &lt; .01; Delta EP: +0.030 +/- 0.011 ng/mL, .05 &lt; P &lt; .1). Although the Delta NE was similar in response to the MAT and MDT, the Delta EP during the MDT tended to be less than half the Delta EP during the MAT (.05 &lt; P &lt; .10). The Delta EP was positively correlated with the Delta DBP and the Delta CO during both tasks and with the Delta SBP and the Delta HR during the MAT. These findings suggest that MAT- and MDT-induced increases in BP were attributable mainly to an increase in CO, possibly as the result of stimulation of the sympathoadrenomedullary system. However, the sympathoadrenomedullary system appeared to be more closely associated with the hemodynamic responses during the MAT than during the MDT. (C) 1997 American Journal of Hypertension, Ltd.

  • Cognitive Behavior Therapy for Eating Disorders: Its Advantages and Shortcomings.

    Kumano H, Yamauchi Y, Matsumoto S, Sakano Y, Kuboki T, Suematsu H

    Japanese Journal of Psychosomatic Medicine   37 ( 1 ) 55 - 60  1997

  • 白衣現象と精神ストレス負荷時昇圧反応の類似点と相違点-心理・行動特性,自律神経機能の側面から-.

    平泉武志, 熊野宏昭, 山内祐一, 宗像正徳, 吉永馨, 田口文人

    Therapeutic Research   18 ( 2 ) 533 - 536  1997

  • タイプA行動パターンと職場ストレスおよび生活習慣の関連について.

    鈴鴨よしみ, 熊野宏昭, 山内祐一

    心身医学   37 ( 5 ) 327 - 336  1997

  • 成人型アトピー性皮膚炎の心身医学的研究(第1報)-特に重症度・臨床経過からみた心理学的特徴の検討-.

    川原健資, 山本晴義, 江花昭一, 津久井要, 佐々木篤代, 加藤一郎, 向井秀樹, 熊野宏昭

    心身医学   37 ( 5 ) 337 - 346  1997

  • 絶食療法における自律神経機能の検討.

    川原健資, 山本晴義, 江花昭一, 津久井要, 佐々木篤代, 熊野宏昭, 末松弘行

    心身医学   37 ( 6 ) 407 - 415  1997

  • Relationships among Type A Behavior Pattern, Job Stress, and Life Styles (2nd Report).

    Suzukamo Y, Kumano H, Yamauchi Y

    Japanese Journal of Psychosomatic Medicine   37 ( 6 ) 417 - 424  1997

  • どのようなダイエット行動が摂食障害傾向やBinge Eatingと関係しているか.

    松本聰子, 熊野宏昭, 坂野雄二

    心身医学   37 ( 6 ) 425 - 432  1997

  • 大腿四頭筋の筋疲労による筋力低下が歩容に及ぼす影響.

    小西由里子, 熊野宏昭, 佐藤明, 大森浩明

    バイオメカニクス研究   1 ( 1 ) 30 - 40  1997

  • 成人型アトピー性皮膚炎の心身医学的研究(第2報)-末梢血好酸球数,LDH,IgEと心理指標の検討-.

    川原健資, 山本晴義, 江花昭一, 津久井要, 佐々木篤代, 加藤一郎, 向井秀樹, 熊野宏昭

    心身医学   37 ( 7 ) 503 - 509  1997

  • Brain Imaging of Patients Suffering from Cancer.

    Tashiro M, Kamada M, Itoh M, Kumano H, Kubota K, Nakagawa Y, Fukushima T, Nakayama K, Higuchi M, Sasaki H

    Journal of International Society of Life Information Science   15 ( 2 ) 408 - 411  1997

  • 光フィードバックの繰り返し施行による生理心理学的変化.

    渡辺宙子, 熊野宏昭, 山内祐一, 藤本敏彦, 安士光男

    心身医学   37 ( 8 ) 575 - 584  1997

  • Influence of Forehead Exposure to Red Photodiode Light on NK Activity.

    Kamei T, Kumano H, Matsumoto T, Yasushi M, Jimbo S

    Photomedicine and Photobiology   19   145 - 148  1997

  • Treatment of a depressive disorder patient with EEG-driven photic stimulation

    H Kumano, H Horie, T Shidara, T Kuboki, H Suematsu, M Yasushi

    BIOFEEDBACK AND SELF-REGULATION   21 ( 4 ) 323 - 334  1996.12  [Refereed]

     View Summary

    This study examined the effects of electroencephalographic- (EEG-) driven photic stimulation on a case of depressive disorder, as measured by a psychometric test of mood states, EEG parameters, and several autonomic indices. The EEG-driven photic stimulation enhances the alpha rhythm of brain waves using photic signals, the brightness of which is modulated by a subject's own alpha rhythm. The patient was a 37-year-old businessman, who was treated for depression with medication during the 13 months prior to his first visit to our hospital. He underwent two sets of inpatient treatment sessions, comprising first 16 and then 18 treatment sessions. The treatments brought about the following changes: an improvement in general mood state, alpha rhythm increase, cardiac parasympathetic suppression and increased skin conductance level. In addition, significant correlations between alpha rhythm increase and cardiac parasympathetic suppression or cardiac sympathetic predominance were observed with each inpatient treatment Significant correlations between alpha rhythm increase, cardiac parasympathetic suppression or cardiac sympathetic predominance and the improvement of general mood state were also observed. Thus, from these observations, it was concluded that the alpha enhancement induced by EEG-driven photic stimulation produced an improvement in the patient's depressive symptomatology connected with cardiac parasympathetic suppression and sympathetic predominance.

  • Whole-body metabolic map with positron emission tomography of a man after running

    T Fujimoto, M Itoh, H Kumano, M Tashiro, T Ido

    LANCET   348 ( 9022 ) 266 - 266  1996.07  [Refereed]

  • 心身医学に行動科学的治療研究を導入する意義.

    熊野宏昭, 佐々木直, 堀江はるみ, 久保木富房, 末松弘行

    心身医学   36 ( 1 ) 39 - 46  1996

  • A Study of Patients Who Died of Eating Disorders.

    Kuboki T, Nomura S, Kumano H, Suematsu H

    Japanese Journal of Psychosomatic Medicine   36 ( 2 ) 107 - 113  1996

  • 心身医学的教育の現状と展望.

    野村忍, 久保木富房, 俵里英子, 熊野宏昭, 大島京子, 吉内一浩, 中尾睦宏, 末松弘行

    心身医学   36 ( 3 ) 249 - 254  1996

  • 急性ストレス障害の阪神・淡路大震災被災者に対する眼球運動による脱感作(EMD)の適用.

    市井雅哉, 熊野宏昭

    ブリーフサイコセラピー研究   5   53 - 68  1996

  • 阪神・淡路大震災における心身医学的諸問題(II)-身体的ストレス反応を中心として.

    辻内琢也, 吉内一浩, 嶋田洋徳, 伊藤克人, 赤林朗, 熊野宏昭, 野村忍, 久保木富房, 坂野雄二, 末松弘行

    心身医学   36 ( 8 ) 657 - 665  1996

  • 阪神・淡路大震災におけるストレスと漢方治療.

    辻内琢也, 吉内一浩, 熊野宏昭, 伊藤克人, 赤林朗, 野村忍, 久保木富房, 末松弘行

    日本東洋心身医学研究   10 ( 1,2 ) 63 - 71  1996

  • 長距離運転と短距離運転がα波とNK細胞活性に与える影響について.

    亀井勉, 安士光男, 熊野宏昭

    神経免疫研究   9 ( 別冊 ) 53 - 57  1996

  • 人参養栄湯により陰陽虚実のスコアの逆転とともに腫瘍マーカーの改善がみられた原発性肺癌の一症例.

    亀井勉, 熊野宏昭, 成相泰夫, 武田勇

    和漢医薬学雑誌   13   494 - 495  1996

  • 呼吸回数が心拍変動に与える影響について.

    中尾睦宏, 熊野宏昭, 久保木富房, 安士光男, 高島香代子

    心身医学   35 ( 6 ) 455 - 462  1995

  • Exercise Tolerance Evaluated by Respiratory Gas Analysis during Treadmill Exercise Test in Panic Disorder Patients.

    Kumano H, Kuboki T, Ide M, Okabe F, Suematsu H

    Japanese Journal of Psychosomatic Medicine   35 ( 8 ) 671 - 679  1995

  • 神経性食欲不振症の行動療法-不食型と大食型の比較-.

    大林正博, 櫻本美輪子, 赤松えり子, 佐々木直, 高野晶, 井出雅弘, 熊野宏昭, 野村忍, 久保木富房, 末松弘行

    心身医療   7 ( 3 ) 377 - 382  1995

  • 心理社会的要因が非インスリン依存型糖尿病に及ぼす影響(その2)-6か月後のフォローアップデータを用いた研究-.

    堀江はるみ, 熊野宏昭, 久保木富房, 末松弘行, 羽倉稜子

    心身医学   35 ( 6 ) 501 - 509  1995

  • 気管支喘息児のαリズムの変化とアレルギー関連検査値の変動との関連性についての検討.

    亀井勉, 木村浩, 安士光男, 熊野宏昭, 桝村純生

    神経免疫研究   8 ( 別冊 ) 59 - 63  1995

  • THE JAPANESE CONCEPT OF INTERDEPENDENCY

    D BERGER, Y ONO, H KUMANO, H SUEMATSU

    AMERICAN JOURNAL OF PSYCHIATRY   151 ( 4 ) 628 - 629  1994.04  [Refereed]

  • 日本語版 Eating Disorder Inventory-91 の因子構造について.

    志村翠, 堀江はるみ, 熊野宏昭, 久保木富房, 末松弘行, 坂野雄二

    行動療法研究   20 ( 2 ) 8 - 15  1994

  • 神経性食欲不振症の認知行動療法-マニュアルを用いた治療研究について-.

    佐々木直, 熊野宏昭, 堀江はるみ, 野村忍, 久保木富房, 末松弘行, 大林正博, 櫻本美輪子

    心身医学   34 ( 2 ) 175 - 182  1994

  • 自己脳波フィードバック光駆動療法の臨床応用に関する研究(第1報)-心理・生理指標に及ぼす効果の検討-.

    川原健資, 山本晴義, 江花昭一, 津久井要, 青沼忠子, 佐々木篤代, 熊野宏昭, 安士光男

    心身医学   34 ( 7 ) 581 - 590  1994

  • 新しい気分調査票の開発とその信頼性・妥当性の検討.

    坂野雄二, 福井知美, 熊野宏昭, 堀江はるみ, 川原健資, 山本晴義, 野村忍, 末松行弘

    心身医学   34 ( 8 ) 629 - 636  1994

  • 光駆動反応によるαリズムの変化が末梢血球数に及ぼす影響.

    亀井勉, 安士光男, 熊野宏昭, 末松弘行, 山崎俊樹, 森竹浩三, 桝村純生

    神経免疫研究   7 ( 別冊 ) 153 - 157  1994

  • 恐慌性障害患者における空間恐怖の治療.

    井出雅弘, 大林正博, 熊野宏昭, 野村忍, 久保木富房, 末松弘行

    心身医療   5 ( 2 ) 233 - 238  1993

  • 摂食障害の治療過程における心理的指標と身体的指標の関連についての研究(第1報).

    小川志郎, 大林正博, 熊野宏昭, 堀江はるみ, 赤林朗, 長瀧真理, 赤松えり子, 野村忍, 久保木富房, 末松弘行

    心身医療   5 ( 4 ) 509 - 515  1993

  • Irrational Beliefs and Images of Body Types in Adolescent Students and Eating Disorders Cases.

    Koshikawa F, Nedate K, Kumano H, Suematsu H, Agari I

    Japanese Health Psychology   2   54 - 63  1993

  • α波フィードバック光駆動装置がもたらす心理学的および生理学的効果-自律訓練法との比較による検討-.

    中本智恵美, 熊野宏昭, 堀江はるみ, 野村忍, 久保木富房, 末松弘行, 安士光男, 斉藤聡, 千々岩克

    心身医学   33 ( 5 ) 371 - 380  1993

  • α波フィードバック光駆動療法により軽快した乗り物恐怖の1例.

    中尾睦宏, 熊野宏昭, 堀江はるみ, 野村忍, 久保木富房, 末松弘行, 福井知美, 高島香代子, 坂野雄二, 安士光男, 坂口正三郎

    心身医療   5 ( 6 ) 821 - 824  1993

  • 抑うつ神経症へのα波フィードバック光駆動療法の適用に関するシングルケース研究.

    熊野宏昭, 堀江はるみ, 久保木富房, 末松弘行, 安士光男, 斉藤聡, 千々岩克, 福井知美, 坂野雄二

    心身医学   33 ( 8 ) 651 - 658  1993

  • 心療内科におけるコンサルテーション活動について-東大心療内科における研究-.

    赤松えり子, 熊野宏昭, 竹内香織, 大林正博, 蓼原学宗, 松波聖冶, 俵里英子, 井出雅弘, 野村忍, 久保木富房, 末松弘行

    心身医学   33 ( 8 ) 675 - 681  1993

  • 心身社会的要因が糖尿病の血糖コントロールに及ぼす影響-数量化I類による多元的な解析による-.

    堀江はるみ, 熊野宏昭, 野村忍, 久保木富房, 末松弘行, 羽倉稜子

    心身医学   33 ( 8 ) 667 - 674  1993

  • 治療経過中著明な腹水を認めた神経性大食症の一例.

    小川志郎, 大林正博, 松山典正, 熊野宏昭, 赤松えり子, 野村忍, 久保木富房, 末松弘行

    心身医療   4 ( 7 ) 832 - 836  1992

  • Decrease of Plasma Substance P Caused by Photic Feedback.

    Kamei T, Yasushi M, Chijiiwa M, Kumano H, Suematsu H, Masumura S

    Photomedicine and Photobiology   14   89 - 94  1992

  • 自律訓練法と循環器系反応.

    野村忍, 竹内香織, 熊野宏昭, 大林雅弘, 久保木富房, 末松弘行

    自律訓練研究   12 ( 1,2 ) 35 - 40  1991

  • 心療内科データベースに関する研究-第1報-.

    野村忍, 井出雅弘, 熊野宏昭, 久保木富房, 末松弘行

    心身医療   3 ( 3 ) 85 - 93  1991

  • 音楽療法が奏功を示した多汗症の1症例.

    竹内香織, 大林正博, 熊野宏昭, 野村忍, 久保木富房, 末松弘行

    心身医療   3 ( 4 ) 556 - 558  1991

  • 東大心療内科におけるコンサルテーション活動(1)-概要-.

    大林正博, 竹内香織, 熊野宏昭, 松波聖治, 井出雅弘, 野村忍, 久保木富房, 末松弘行

    心身医療   3 ( 4 ) 550 - 555  1991

  • INTERRELATIONSHIP BETWEEN SERUM MUSCLE ENZYMES AND A LOW T3 IN ANOREXIA-NERVOSA

    H KUMANO, T KUBOKI, R TAWARA, T SASAKI, S NOMURA, H SUEMATSU, E OGATA

    ENDOCRINOLOGIA JAPONICA   37 ( 4 ) 583 - 589  1990.08  [Refereed]

  • 多食症に対する心理教育的アプローチ-認知行動療法的アプローチと交流分析療法を経時的に施行した二症例-.

    熊野宏昭, 和田迪子, 長瀧真理, 野村忍, 久保木富房, 末松弘行

    交流分析研究   14 ( 1,2 ) 43 - 49  1990

  • Panic Disorderにおける乳酸負荷.

    大林正博, 井出雅弘, 熊野宏昭, 津久井要, 苅部千恵, 野村忍, 久保木富房, 末松弘行

    心身医療   2 ( 6 ) 894 - 903  1990

  • フィンガーペインティングを用いた心因性難聴の一例.

    赤松えり子, 熊野宏昭, 松波聖治, 高野晶, 野村忍, 久保木富房, 末松弘行

    心身医療   1 ( 4 ) 553 - 557  1989

  • Panic Disorderの臨床研究.

    井出雅弘, 久保木富房, 熊野宏昭, 野村忍, 末松弘行

    心身医療   1 ( 8 ) 1180 - 1185  1989

  • クレゾール中毒.

    熊野宏昭, 黒木啓文, 堤晴彦, 豊岡秀訓, 三井香児, 西原カズヨ

    月刊薬事   28 ( 8 ) 1697 - 1701  1986

  • WHY ARE CADAVERIC RENAL-TRANSPLANTS SO HARD TO FIND IN JAPAN - AN ANALYSIS OF ECONOMIC AND ATTITUDINAL ASPECTS

    G OHI, T HASEGAWA, H KUMANO, KAI, I, N TAKENAGA, Y TAGUCHI, H SAITO, T INO

    HEALTH POLICY   6 ( 3 ) 269 - 278  1986  [Refereed]

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Books and Other Publications

  • 実践!マインドフルネスDVD-体験に気づき、反応を止め、パターンから抜け出す理論と実践

    熊野宏昭( Part: Sole author)

    2020.01

  • ストレスに負けない!心のストレッチ-はじめてのマインドフルネス.

    熊野宏昭

    NHK出版  2017

  • 実践!マインドフルネス-今この瞬間に気づき青空を感じるレッスン.

    熊野宏昭, 富田望, 樋沼友子, 荒木美乃里, 黒田彩加

    サンガ  2016

  • 新世代の認知行動療法.

    熊野宏昭

    日本評論社  2012

  • マインドフルネスそしてACTへ-二十一世紀の自分探しプロジェクト.

    熊野宏昭

    星和書店  2011

  • 二十一世紀の自分探しプロジェクト-キャラの檻から出て、街に出かけよう.

    熊野宏昭

    サンガ  2009

  • ストレスに負けない生活-心・身体・脳のセルフケア.

    熊野宏昭

    筑摩書房  2007

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Misc

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Research Projects

  • 中高年のこころの習慣と脳のコホート研究-精神的健康の予測と改善を目指して

    Project Year :

    2020.04
    -
    2025.03
     

  • Using attentional function to detecting early stage of mental illness and recovery from it

    Project Year :

    2019.04
    -
    2022.03
     

  • An Empirical Research on the Buddhist Meditaion(zhiguan) and Mindfulness by Cooperation of Buddhism, Psychology and Brain Science

    Project Year :

    2018.06
    -
    2021.03
     

  • The self-focused attention and the threat monitoring in social anxiety: Optimization of the intervention to attentional dysfunction.

    Project Year :

    2016.04
    -
    2019.03
     

     View Summary

    First, we developed subjective and objective measurements of self-focused attention and threat monitoring for social anxiety. It was revealed that the hyperactivity in the frontopolar area is an objective measurement of self-focused attention, whereas hyperactivity in the superior temporal gyrus is an objective measurement of external attention. Second, we investigated the mechanism of the "Situational Attentional Refocusing (SAR)" that is an intervention for threat monitoring. It was suggested that the change of metacognition to threat monitoring is important for the SAR. Finally, we revised the Attention Training Technique (ATT) to improve the self-focused attention in social anxiety and investigated its effect. As a result, the score of the fear of social situation and the rumination about social situation were significantly decreased only in the group treated by the revised ATT

  • Development of a Package of Dementia Support Programs based on Multi-generational Approach

    Project Year :

    2013.04
    -
    2016.03
     

     View Summary

    [Purpose]This research aimed to develop a package of multi-generational programs to support people with dementia(PWD).[Method]Questionnaires were mailed to citizens age 40 and older. A package of six action research studies was conducted: implementing a series of lectures and workshops ; delivering a study program in elementary schools; organizing a volunteer group;collaborating regular meetings of community care professionals; delivering mindfulness therapy for caregivers; and intervening to in old apartments. The Social Capital Scale administrated at baseline and at 24 months. [Results] The respondents in the follow-up survey confirmed the decline of the ratio of participants in community activities; however the increased ratio of people who hoped to help neighbors was statistically significant.[Conclusion] Multi-generational education programs,including volunteer placement and support, must encourage residents to join activities to help PWD and their families

  • The effectiveness of attention training on the prefrontal dysfunction in depression

    Project Year :

    2013.04
    -
    2016.03
     

     View Summary

    To indicate the effectiveness of attention training (ATT) for major depression, ATT was used for 10 major depressive patients during 7 weeks, whose effects were investigated by psychological, behavioral and brain function measures. After the training, negative rumination and trait anxiety were reduced and divided attention was increased. Depressive symptoms and detached mindfulness that is distancing attentiveness were inclined to decrease and increase, respectively. Based on the correlation patterns of the changes of each variable, the increase of divided attention led to the increase of detached mindfulness, then to the decrease of depressive symptoms. Moreover, the increase of attention regulation function by ATT was shown to be associated with the increase of the blood flow of left dorsolateral prefrontal cortex (DLPFC), right DLPFC and right middle temporal gyrus

  • Integrative neuroimaging study for self awareness and meta recognition system in alexithymia

    Project Year :

    2011.04
    -
    2016.03
     

     View Summary

    Alexithymia is an important psychopathology which manifests inability to identify self’s emotion and difficulty in expressing it. The aim of this study is to reveal neural basis of the relationship between body and mind status changes, using functional magnetic resonance imaging (fMRI). For self-continuity based on autobiographical information, we created web system to record everyday events and found that positive memories are more retained than negative ones, which involves hippocampus activities. We also measured brain activity with fMRI and concurrently heart rate variability (HRV) in response to emotional stimuli, and found insula and ventromedical prefrontal activity and connectivity were correlated with parasympathetic factor in HRV. Oversensitivity to interoceptive information increased anxiety and insula activity was decreased in alexithymia

  • Signal processing and interpretation of physical activity time series

    Project Year :

    2003
    -
    2005
     

     View Summary

    The aim of this project was to evaluate the relationship between ecologically measured psychological symptoms and physical activity data in patients with psychiatric and psychosomatic disorders and healthy adolescents, and to develop methods to extract the altered physical activity patterns related to the symptom worsening.(1)Research on patients with chronic fatigue syndrome (CFS)We developed a new method based on the wavelet transform to characterize the physical activity time series, which can evaluate the temporal correlation at the interruption of activities by the negative modulus maxima of the transform. We found that up to 35 min the local correlation property was significantly smaller in CFS patients than in controls, suggesting that CFS patients have more abrupt interruptions of physical activity.(2)Research on junior high school studentsWe found that subjective moods and fatigue in these subjects had significant correlations with statistical indices calculated from 30 min activity data before each measurement. In a multiple regression model incorporating statistics of activity data to estimate subjective fatigue, the mean and detrended skewness and their interaction term were highly significant as fatigue estimators. The detrended skewness which is related to abrupt drop or interruption of activities showed the highest significance.(3)Research on patients with major depressionWe found that durations of resting periods having continuously smaller counts than the overall recorded average of activity obey a power-law cumulative distribution over more than two decades (from 2 min to 200 min) in both control subjects and major depression patients. The power-law exponent of major depression patients was significantly smaller than that of healthy individuals, implying more frequent episodes of longer resting periods in the patients.These results (1)-(3) suggest that psychiatric and psychosomatic symptoms can be quantified and predicted by the statistical parameters at the interruption of physical activity

  • Signal processing and interpretation of physical activity time series

    Project Year :

    2003
    -
    2005
     

     View Summary

    The aim of this project was to evaluate the relationship between ecologically measured psychological symptoms and physical activity data in patients with psychiatric and psychosomatic disorders and healthy adolescents, and to develop methods to extract the altered physical activity patterns related to the symptom worsening.(1)Research on patients with chronic fatigue syndrome (CFS)We developed a new method based on the wavelet transform to characterize the physical activity time series, which can evaluate the temporal correlation at the interruption of activities by the negative modulus maxima of the transform. We found that up to 35 min the local correlation property was significantly smaller in CFS patients than in controls, suggesting that CFS patients have more abrupt interruptions of physical activity.(2)Research on junior high school studentsWe found that subjective moods and fatigue in these subjects had significant correlations with statistical indices calculated from 30 min activity data before each measurement. In a multiple regression model incorporating statistics of activity data to estimate subjective fatigue, the mean and detrended skewness and their interaction term were highly significant as fatigue estimators. The detrended skewness which is related to abrupt drop or interruption of activities showed the highest significance.(3)Research on patients with major depressionWe found that durations of resting periods having continuously smaller counts than the overall recorded average of activity obey a power-law cumulative distribution over more than two decades (from 2 min to 200 min) in both control subjects and major depression patients. The power-law exponent of major depression patients was significantly smaller than that of healthy individuals, implying more frequent episodes of longer resting periods in the patients.These results (1)-(3) suggest that psychiatric and psychosomatic symptoms can be quantified and predicted by the statistical parameters at the interruption of physical activity

  • Limbic Brain Hypometabolism in Patients Having Cancer : A PET Study

    Project Year :

    1998
    -
    1999
     

     View Summary

    Patients suffering from malignant disease are very prone to develop severe psychosomatic trauma due to the devastating nature of the ailment and aggressive treatment approach. Our study was aimed to document the psycho-psychiatric abnormalities developed in patients suffering from cancer using brain imaging technique. Brain images of cancer and benign patients were taken by positron emission tomography (PET) after infusion of [18F]-fluoro-deoxy-glucose as a tracer. The imaging results were compared between the cancer patients and the patients suffering a benign disease. The data were analyzed using statistical parametrical mapping technique (SPM96) developed by Friston et al (London, U.K.).
    Our results have well illustrated the following imaging findings in the brain substrates. (1) Cancer patients have shown regional metabolic abnormality in the limbic structures of the brain with a remarkable decrement and noticeable decline was observed also in the frontal cortex. (2) This metabolic decline has shown some noted correlation with the course of treatments. It was more widely and significantly distributed in patients studied at their initial admission to a hospital prior to application of any specific treatment. Subsequently, the regions were regressed markedly after the completion of the therapeutic regimen of chemotherapy and/or radiation therapy. However, similar extensive metabolic abnormalities were again noted in those patients in whom the cancer had recurred. (3) We have speculated that these abnormalities were strongly associated with psychological factors such as depressive and anxiety disorders which also was later confirmed by asking a standard psychological questionnaire.

  • Limbic Brain Hypometabolism in Patients Having Cancer : A PET Study

    Project Year :

    1998
    -
    1999
     

     View Summary

    Patients suffering from malignant disease are very prone to develop severe psychosomatic trauma due to the devastating nature of the ailment and aggressive treatment approach. Our study was aimed to document the psycho-psychiatric abnormalities developed in patients suffering from cancer using brain imaging technique. Brain images of cancer and benign patients were taken by positron emission tomography (PET) after infusion of [18F]-fluoro-deoxy-glucose as a tracer. The imaging results were compared between the cancer patients and the patients suffering a benign disease. The data were analyzed using statistical parametrical mapping technique (SPM96) developed by Friston et al (London, U.K.).
    Our results have well illustrated the following imaging findings in the brain substrates. (1) Cancer patients have shown regional metabolic abnormality in the limbic structures of the brain with a remarkable decrement and noticeable decline was observed also in the frontal cortex. (2) This metabolic decline has shown some noted correlation with the course of treatments. It was more widely and significantly distributed in patients studied at their initial admission to a hospital prior to application of any specific treatment. Subsequently, the regions were regressed markedly after the completion of the therapeutic regimen of chemotherapy and/or radiation therapy. However, similar extensive metabolic abnormalities were again noted in those patients in whom the cancer had recurred. (3) We have speculated that these abnormalities were strongly associated with psychological factors such as depressive and anxiety disorders which also was later confirmed by asking a standard psychological questionnaire.

  • The System Development for the Scientific Formulation of Treatment Processes by Using Personal Digital Assistance

     View Summary

    This study aimed at the system development for the scientific formulation of treatment processes targeting psychosomatic diseases or panic disorder utilizing the methods of computerlized Ecological Momentary Assessment (cEMA). cEMA is a recently developed time-series momentary assessment method of one's signs and symptoms in actual life using a personal digital assistance (PDA).Firstly, we demonstrated the merit of using cEMA for the assessment of pathologic conditions of the patients with tension-type headache or panic disorder, and showed the newly found pathologic mechanisms of these diseases.Secondly, the program of cognitive behavior therapy (CBT) operating on the Windows Mobile PDA was developed for the agoraphobic symptoms of panic disorder patients, which enabled on-site behavioral process control by showing in a graph the real-time anxiety level every 5 minutes. As a result of applying it to the four patients with panic disorder and agoraphobia, it was remarkably effective and the precise data of intervention processes were obtained. The program of CBT using a pocket notebook was also developed and tested for moderately depressed university students, which indicated that the method of recording by remembering later was superior to that of recording immediately after experiencing a depressive mood.Thirdly, we developed the methods for analyzing and interpreting the time-series ecological data and intervention process data. We could thus investigate the pathologic mechanisms of tension-type headache and panic disorder that had never been clarified. In addition, we indicated that the necessary condition for invoking the desirable behavior modification in everyday life is somewhat different from that for accurate assessment by EMA. The latter requires the ecological validity that is assured by not informing the subjects of the results of assessment, while the former contains a self-monitoring method as a vital ingredient that surely informs the subjects of the results of assessment

  • The research about chemical compounds exposure and health effect of Multiple Chemical Sensitivity in daily life

  • Development of a questionnaire for diagnosis of MCS/SHS in Japan

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Specific Research

  • 中高年のこころの習慣と脳のコホート研究-精神的健康の予測と改善を目指して

    2020   高橋徹

     View Summary

    早稲田大学の卒業生を対象としたコホート研究のための準備を進めた。具体的には、脳の変化を媒介して高い幸福度をもたらすと想定している心の習慣であるマインドフルネスを簡便に測定する尺度の開発を行った。マインドフルネスとは、現在の体験にありのままに気づく心のあり方であり、Five Facet Mindfulness Questionnaireなどの自己評定尺度で測定するのが主流であるが、39項目と比較的項目数が多く負担があるという問題があった。特に、本研究課題のコホート研究は、その他にも多くの測定を実施するため、少しでも負担を減らすことが重要であることから、項目数を削減した短縮版の開発を行った。

  • 社交不安症における自己注目と脅威モニタリング:注意制御不全への介入方法の最適化

    2019   富田望

     View Summary

     本研究では、社交不安症における注意の偏り(自己注目、脅威モニタリング)を制御する「メタ認知的信念」の介入効果を検討した。社交不安傾向を有する大学生22名を介入群と統制群に振り分け、介入群にはメタ認知的信念に関する心理教育を実施した。効果指標としては、社交不安症状を測定する質問紙と、注意の偏りを測定する認知課題およびスピーチ課題時における視線の停留時間を用いた。その結果、介入群において、社交不安症状は有意に低減したが、注意の偏りは有意な変化が示されなかった。以上より、メタ認知的信念への介入は、注意の偏り自体への直接的な効果はないものの、社交不安症状を低減する上で有用である可能性が示唆された。

  • うつ病の病態維持に関る前頭葉機能異常と注意制御機能訓練の治療効果

    2012  

     View Summary

     本研究の進捗状況としては、注意訓練(Attention Training; ATT)課題、効果の評価課題、光トポグラフィ(NIRS)と機能性核磁気共鳴画像(fMRI)のそれぞれを用いた実験のプロトコールを作成し、予備的検討を続けてきた。また、本研究の基礎になる観点を総説論文の形にまとめ、『心身相関医学の最新知識』に発表した。 ATT課題では、音源を複数用意し、研究従事者及び大学院生に聞き取りやすさ等を調査し、適切な音源を作成した。また、予備実験として、大学生を対象とした介入実験を行った。実験は、統制期間10日間、介入期間10日間とし、ATTを行う前には心理教育を実施した。介入期間には被験者にホームワークを課し、ATTを1日15分行うように伝えた。そして、ATTを行った時間・場所・周囲の状況・集中度・雑念が浮かんだ時の対処法の記入も求めた。結果は、抑うつには効果はみられなかったものの、反芻には有意な改善がみられた。抑うつに効果がみられなかったことに関しては、介入期間の短さや、元々の抑うつの低さが原因として考えられた。 NIRS用の評価課題としては、注意制御機能の3 つのコンポーネント(注意の選択、転換、分割)の測定が可能となる両耳分離聴課題を作成している。作成に当たっては、研究従事者及び大学院生に課題の難易度、聴覚刺激の聞き取りやすさ等に関する意見を求め、修正を繰り返している。fMRI用の評価課題としては、脳機能レベルで両耳分離聴課題(上記とは別課題)、PASATを、行動レベルでEmotional Distraction課題を作成した。後者については、情動刺激を選定し、プログラムの改良と予備実験を繰り返している。両耳分離聴課題とPASATについては、fMRIを用いた予備実験を5名実施した結果に基づいて課題を改良し、再度、課題やプロトコールの評価のために予備実験を10名について実施することを予定している。現在、6名実施し、結果の整理、分析を随時実施している。 以上の成果を踏まえて提出した研究計画が、平成25年~27年度の基盤研究(C)に採択されたので、予備実験の結果を踏まえてこれから本実験に取り掛かる予定である。

 

Syllabus

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