Updated on 2025/09/14

写真a

 
TANIMOTO, Yuki
 
Affiliation
Faculty of Science and Engineering, Waseda Research Institute for Science and Engineering
Job title
Junior Researcher(Assistant Professor)
Degree
PhD ( 2017.06 Osaka University )

Research Experience

  • 2024.04
    -
    Now

    RIKEN   Center for Brain Science   Visiting Scientist

  • 2024.04
    -
    Now

    Waseda University   Research Institute for Science and Engineering

  • 2022.10
    -
    2024.03

    RIKEN   Center for Brain Science   Research Scientist

  • 2019.04
    -
    2022.09

    RIKEN   Center for Brain Science   Special Postdoctoral Researcher

  • 2017.09
    -
    2019.03

    RIKEN   Center for Brain Science   Research Scientist

  • 2017.04
    -
    2017.09

    Osaka University   Graduate School of Science, Department of Biological Sciences

  • 2014.04
    -
    2017.03

    Japan Society for the Promotion of Science

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Education Background

  • 2014.04
    -
    2017.03

    Osaka University   Graduate School of Science   Department of Biological Sciences  

  • 2012.05
    -
    2017.03

    博士課程教育リーディングプログラム 生体統御ネットワーク医学教育プログラム 第一期生  

  • 2012.04
    -
    2014.03

    Osaka University   Graduate School of Science   Department of Biological Sciences  

  • 2008.04
    -
    2012.03

    Osaka Univ.   School of Science  

Professional Memberships

  • 　
    　
    　

    THE JAPAN NEUROSCIENCE SOCIETY

Research Areas

  • Neuroscience-general   Neural Circuit Function

Research Interests

  • ゼブラフィッシュ

  • Comprehensive Brain Science Network

Awards

  • 若手優秀発表賞

    2019.12   次世代脳プロジェクト冬のシンポジウム2019   Basal ganglia output to cortex encodes predictive information for goal-directed behavior in zebrafish

 

Papers

  • Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish.

    Yuki Tanimoto, Hisaya Kakinuma, Ryo Aoki, Toshiyuki Shiraki, Shin-Ichi Higashijima, Hitoshi Okamoto

    Cell reports     113916 - 113916  2024.03  [International journal]

    　View Summary

    The cortico-basal ganglia circuit mediates decision making. Here, we generated transgenic tools for adult zebrafish targeting specific subpopulations of the components of this circuit and utilized them to identify evolutionary homologs of the mammalian direct- and indirect-pathway striatal neurons, which respectively project to the homologs of the internal and external segment of the globus pallidus (dorsal entopeduncular nucleus [dEN] and lateral nucleus of the ventral telencephalic area [Vl]) as in mammals. Unlike in mammals, the Vl mainly projects to the dEN directly, not by way of the subthalamic nucleus. Further single-cell RNA sequencing analysis reveals two pallidal output pathways: a major shortcut pathway directly connecting the dEN with the pallium and the evolutionarily conserved closed loop by way of the thalamus. Our resources and circuit map provide the common basis for the functional study of the basal ganglia in a small and optically tractable zebrafish brain for the comprehensive mechanistic understanding of the cortico-basal ganglia circuit.

    DOI PubMed

    Scopus

    4
    Citation
    (Scopus)

  • The serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project to the dorsal pallium in zebrafish.

    Kotaro Shibayama, Haruna Nakajo, Yuki Tanimoto, Hisaya Kakinuma, Toshiyuki Shiraki, Takashi Tsuboi, Hitoshi Okamoto

    Neuroscience research    2024.03  [International journal]

    　View Summary

    The serotonergic neurons in the raphe nucleus are implicated in various cognitive functions such as learning and emotion. In vertebrates, the raphe nucleus is divided into the dorsal raphe and the median raphe. In contrast to the abundance of knowledge on the functions of the dorsal raphe, the roles of the serotonergic neurons in the median raphe are relatively unknown. The studies using zebrafish revealed that the median raphe serotonergic neurons receive input from the two distinct pathways from the habenula and the IPN. The use of zebrafish may reveal the function of the Hb-IPN-median raphe pathway. To clarify the functions of the median raphe serotonergic neurons, it is necessary to distinguish them from those in the dorsal raphe. Most median raphe serotonergic neurons originate from rhombomere 2 in mice, and we generated the transgenic zebrafish which can label the serotonergic neurons derived from rhombomere 2. In this study, we found the serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project axons to the rostral dorsal pallium in zebrafish. This study suggests that this transgenic system has the potential to specifically reveal the function and information processing of the Hb-IPN-raphe-telencephalon circuit in learning.

    DOI PubMed

    Scopus

  • Neural mechanism of experience-dependent sensory gain control in C. elegans.

    Yosuke Ikejiri, Yuki Tanimoto, Kosuke Fujita, Fumie Hiramatsu, Shuhei J Yamazaki, Yuto Endo, Yasushi Iwatani, Koichi Fujimoto, Koutarou D Kimura

    Neuroscience research   191   77 - 90  2023.06  [International journal]

    DOI PubMed

    Scopus

    3
    Citation
    (Scopus)

  • Calcium Imaging of Neuronal Activity under Gradually Changing Odor Stimulation in Caenorhabditis elegans.

    Yuki Tanimoto, Koutarou D Kimura

    Bio-protocol   11 ( 1 ) e3866  2021.01  [International journal]

    DOI PubMed

    Scopus

    2
    Citation
    (Scopus)

  • Neuronal, mathematical, and molecular bases of perceptual decision-making in C. elegans.

    Yuki Tanimoto, Koutarou D Kimura

    Neuroscience research   140   3 - 13  2019.03  [Refereed]  [International journal]

    DOI PubMed

    Scopus

    10
    Citation
    (Scopus)

  • STEFTR: A Hybrid Versatile Method for State Estimation and Feature Extraction From the Trajectory of Animal Behavior.

    Shuhei J Yamazaki, Kazuya Ohara, Kentaro Ito, Nobuo Kokubun, Takuma Kitanishi, Daisuke Takaichi, Yasufumi Yamada, Yosuke Ikejiri, Fumie Hiramatsu, Kosuke Fujita, Yuki Tanimoto, Akiko Yamazoe-Umemoto, Koichi Hashimoto, Katsufumi Sato, Ken Yoda, Akinori Takahashi, Yuki Ishikawa, Azusa Kamikouchi, Shizuko Hiryu, Takuya Maekawa, Koutarou D Kimura

    Frontiers in neuroscience   13 ( JUN ) 626 - 626  2019  [Refereed]  [International journal]

    DOI PubMed

    Scopus

    10
    Citation
    (Scopus)

  • Calcium dynamics regulating the timing of decision-making in C. elegans.

    Yuki Tanimoto, Akiko Yamazoe-Umemoto, Kosuke Fujita, Yuya Kawazoe, Yosuke Miyanishi, Shuhei J Yamazaki, Xianfeng Fei, Karl Emanuel Busch, Keiko Gengyo-Ando, Junichi Nakai, Yuichi Iino, Yuishi Iwasaki, Koichi Hashimoto, Koutarou D Kimura

    eLife   6  2017.05  [Refereed]  [International journal]

    DOI PubMed

    Scopus

    42
    Citation
    (Scopus)

  • In actio optophysiological analyses reveal functional diversification of dopaminergic neurons in the nematode C. elegans.

    Yuki Tanimoto, Ying Grace Zheng, Xianfeng Fei, Yukako Fujie, Koichi Hashimoto, Koutarou D Kimura

    Scientific reports   6   26297 - 26297  2016.05  [Refereed]  [International journal]

    DOI PubMed

    Scopus

    21
    Citation
    (Scopus)

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Presentations

  • TRANSGENIC TOOLS TARGETING STRIATAL AND PALLIDAL SUBPOPULATIONS HAVE REVEALED EVOLUTIONARY CONSERVATION AND SPECIALIZATION OF THE CORTICO-BASAL GANGLIA CIRCUIT IN ZEBRAFISH

    Tanimoto Y, Kakinuma H, Aoki R, Higashijima S, Okamoto H

    Zebrafish Neurobiology 2023, Cold Spring Harbor 

    Presentation date： 2023.11

  • A CORTICO-BASAL GANGLIA CIRCUIT MECHANISM FOR DECISION-MAKING BASED ON FUTURE STATE PREDICTION ERROR IN GOAL DIRECTED BEHAVIOR OF ADULT ZEBRAFISH

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    Zebrafish Neurobiology 2023, Cold Spring Harbor 

    Presentation date： 2023.11

  • A cortico-basal ganglia circuit mechanism for decision-making based on future state prediction error in goal directed behavior of adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    Presentation date： 2023.09

  • ゼブラフィッシュの大脳皮質−基底核回路による予測に基づいた意思決定機構

    谷本悠生, 鳥越万紀夫, イスラムタンビル, 青木亮, 白木利幸, 柿沼久哉, 岡本仁

    第46回日本神経科学大会, 仙台市 

    Presentation date： 2023.08

  • How does zebrafish predict the future and use the prediction for decision-making?

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    Presentation date： 2022.09

  • ゼブラフィッシュの大脳基底核における目標指向行動のための価値情報の機能的分離と統合

    谷本悠生, 鳥越万紀夫, イスラムタンビル, 青木亮, 白木利幸, 柿沼久哉, 岡本仁

    第45回日本神経科学大会（NEURO2022）, 宜野湾市 

    Presentation date： 2022.07

  • Learning of value information by the basal ganglia circuit in goal-directed behavior of adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    Presentation date： 2021.09

  • Learning of value information by the basal ganglia circuit in goal-directed behavior of adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    第44回日本神経科学大会, 神戸/オンライン 

    Presentation date： 2021.07

  • Basal ganglia output to cortex bi-directionally encodes positive and negative values for goal-directed behavior in adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Kakinuma H, Okamoto H

    11th European Zebrafish Meeting 2020, Czech 

    Presentation date： 2020.10

  • Basal ganglia output to cortex bi-directionally encodes positive and negative values for goal-directed decision-making in adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Kakinuma H

    Presentation date： 2020.07

  • Basal ganglia output to cortex encodes predictive information for goal-directed behavior in zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Kakinuma H, Okamoto H

    Presentation date： 2019.12

  • Calcium imaging of basal ganglia output to dorsal pallium during decision-making in adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Kakinuma H, Okamoto H

    Zebrafish Neural Circuits and Behavior 2019, Cold Spring Harbor 

    Presentation date： 2019.11

  • 意思決定中のゼブラフィッシュの大脳基底核―皮質経路の神経活動ダイナミクス

    谷本悠生, 鳥越万紀夫, イスラム タンビル, 青木亮, 柿沼久哉, 岡本仁

    Presentation date： 2019.07

  • 線虫C. elegansの嗅覚ナビゲーションにおける意思決定のための時間積分器の同定

    谷本 悠生

    第40回日本神経科学大会、千葉 

    Presentation date： 2017.07

  • Calcium dynamics regulates the timing of decision-making in worms

    Yuki Tanimoto

    21st International C. elegans Meeting, Los Angeles 

    Presentation date： 2017.06

  • 線虫C. elegans のIn actio光生理学的解析によるドーパミンニューロンの機能的分化の解明

    谷本 悠生

    第39回日本神経科学大会、横浜 

    Presentation date： 2016.07

  • In actio optophysiological analyses reveal functional diversification of dopaminergic neurons in the nematode C. elegans

    Tanimoto Y, Zheng YG, Fei X, Fujie Y, Hashimoto K, Kimura K

    CeNeuro2016, Nagoya 

    Presentation date： 2016.07

  • Neuronal mechanisms for C. elegans olfactory navigation revealed by a highly integrated microscope system

    Yuki Tanimoto

    20th International C. elegans Meeting, Los Angeles 

    Presentation date： 2015.06

  • Optophysiological dissection of individual dopaminergic neuron pairs during food-dependent behavioral modulation

    Yuki Tanimoto

    20th International C. elegans Meeting, Los Angeles 

    Presentation date： 2015.06

  • Neuronal mechanisms of decision making in C. elegans olfactory behavior revealed by a highly integrated microscope system

    Yuki Tanimoto

    The 37th Annual Meeting of the Japan Neuroscience Society 

    Presentation date： 2014.09

  • Neuronal mechanisms of decision making in C. elegans olfactory behavior revealed by a highly integrated microscope system.

    Yuki Tanimoto

    C. elegans Development Topic Meeting / Asia-Pacific C. elegans Meeting, Nara 

    Presentation date： 2014.07

  • A virtual reality running machine for worms‒a highly integrated microscope system for olfactory behavior

    Yuki Tanimoto

    19th International C. elegans Meeting, Los Angeles 

    Presentation date： 2013.06

  • A neuronal algorithm for sensory behavior in C. elegans revealed by a highly integrated microscope system

    Yuki Tanimoto

    Presentation date： 2013.06

  • 統合型解析顕微鏡システムの開発

    谷本 悠生

    包括型 脳科学研究推進支援ネットワーク夏のワークショップ、仙台 

    Presentation date： 2012.07

  • A virtual reality running machine for worms–a highly integrated tracking system for olfactory behavior

    Yuki Tanimoto

    5th East Asia C. elegans Meeting, Taipei 

    Presentation date： 2012.06

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Research Projects

  • ゼブラフィッシュの予測に基づいた意思決定における大脳皮質-基底核回路の機能の解明

    日本学術振興会  科学研究費助成事業

    Project Year :

    2020.04
    -
    2023.03
     

    谷本 悠生

    　View Summary

    動物は絶えず変化する周囲の状況に応じて適切な意思決定を行う。これまで意思決定においては、過去の経験依存的に適切な行動が引き起こされる仕組みが研究されてきた。一方、動物は未知の状況においても到達すべき状況を予測し、適切な行動を選択する。この予測に基づいた意思決定は、我々ヒトの精神活動においても根幹をなす脳機能の一つであるが、そのメカニズムは不明な点が多い。本研究では、ゼブラフィッシュのコンパクトな大脳皮質-基底核回路を活かして、予測に基づいた意思決定中の神経活動を計測・操作し、予測情報が統合され適切な行動に反映される神経回路機構の解明を目指す。これまでの結果から、ゼブラフィッシュの淡蒼球内節に相当する細胞から大脳皮質への情報出力において、周囲の状況の危険度の予測情報が伝達されていることが既に判明していた。前年度においては、この淡蒼球内節に相当する細胞の活動を制御している上流の神経核である線条体の直接路・間接路細胞が仮想空間でのGo/No-go課題学習中にどのような活動を示すかをカルシウムイメージングにより計測する方法を確立した。本年度は、線条体直接路・間接路のイメージング実験を継続および統計的な解析を行い、学習依存的なクラスター活動の変化を計測することに成功した。さらに本年度は、淡蒼球内節、線条体の直接路・間接路細胞に加えて、所属研究室で過去に計測された大脳皮質相当領域のイメージング結果を統合的に解釈し、ゼブラフィッシュの大脳皮質ー基底核回路が全体としてどのような計算を行い、最終的に特定の状況下で適切な予測や行動をとることができるかの神経回路モデルを作成した。以上の成果により、脊椎動物の大脳皮質ー基底核回路が、適切な到達すべき状況の予測と、それに基づいた行動選択を行う基本的な計算原理を提唱した。

  • 統合型解析顕微鏡を用いた線虫C. elegansの感覚応答行動制御メカニズムの解明

    独立行政法人 日本学術振興会  特別研究員奨励費

    Project Year :

    2014.04
    -
    2017.03
     

    谷本 悠生

Misc

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