Updated on 2026/05/25

写真a

 
TANIMOTO, Yuki
 
Affiliation
Faculty of Science and Engineering, Waseda Research Institute for Science and Engineering
Job title
Junior Researcher(Assistant Professor)
Degree
PhD ( 2017.06 Osaka University )

Research Experience

  • 2024.04
    -
    Now

    RIKEN   Center for Brain Science   Visiting Scientist

  • 2024.04
    -
    Now

    Waseda University   Research Institute for Science and Engineering

  • 2022.10
    -
    2024.03

    RIKEN   Center for Brain Science   Research Scientist

  • 2019.04
    -
    2022.09

    RIKEN   Center for Brain Science   Special Postdoctoral Researcher

  • 2017.09
    -
    2019.03

    RIKEN   Center for Brain Science   Research Scientist

  • 2017.04
    -
    2017.09

    Osaka University   Graduate School of Science, Department of Biological Sciences

  • 2014.04
    -
    2017.03

    Japan Society for the Promotion of Science

▼display all

Education Background

  • 2022.07
    -
    2022.08

    Imaging Structure & Function in the Nervous System 2022   Cold Spring Harbor Laboratory, Courses & Workshops  

  • 2014.04
    -
    2017.03

    Osaka University   Graduate School of Science   Department of Biological Sciences  

  • 2012.05
    -
    2017.03

    博士課程教育リーディングプログラム 生体統御ネットワーク医学教育プログラム 第一期生  

  • 2012.04
    -
    2014.03

    Osaka University   Graduate School of Science   Department of Biological Sciences  

  • 2008.04
    -
    2012.03

    Osaka Univ.   School of Science  

Committee Memberships

  • 2022.05
    -
    　

    理化学研究所  研究奨励ファンド審査員

  • 2021.05
    -
    　

    理化学研究所  研究奨励ファンド審査員

Professional Memberships

  • 　
    　
    　

    THE JAPAN NEUROSCIENCE SOCIETY

Research Areas

  • Neuroscience-general

Awards

  • Oubu Award

    2025.03   RIKEN   Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish

  • NSR Excellent Paper Award

    2025   日本神経科学学会   The serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project to the dorsal pallium in zebrafish

    Winner： Shibayama K., Nakajo H., Tanimoto Y., Kakinuma H., Shiraki T., Tsuboi T., Okamoto H.

  • NSR Best Paper Award

    2024   日本神経科学学会   Neural mechanism of experience-dependent sensory gain control in C. elegans

    Winner： Ikejiri Y., Tanimoto Y., Fujita K., Hiramatsu F., Yamazaki SJ, Endo Y., Iwatani Y., Fujimoto K., Kimura K.

  • 若手優秀発表賞

    2019.12   次世代脳プロジェクト冬のシンポジウム2019   Basal ganglia output to cortex encodes predictive information for goal-directed behavior in zebrafish

  • 卒業研究発表会 表彰状 第1位

    2012.02   大阪大学理学部 生物科学科 ３年生一同   統合的感覚応答行動解析システムの開発

    Winner： 谷本 悠生

 

Papers

  • Virtual social interaction reveals that the dorsal habenula-IPN pathway is essential for targeting the opponent

    Tanvir Islam, Makio Torigoe, Yuki Tanimoto, Ming-Yi Chou, Hitoshi Okamoto

    ISCIENCE   29 ( 5 )  2026.05  [Refereed]

    DOI

    Scopus

  • Adult zebrafish can learn Morris water maze-like tasks in a two-dimensional virtual reality system

    Tanvir Islam, Makio Torigoe, Yuki Tanimoto, Hitoshi Okamoto

    Cell Reports Methods    2024.10  [Refereed]

    DOI

    Scopus

    6
    Citation
    (Scopus)

  • Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish.

    Yuki Tanimoto, Hisaya Kakinuma, Ryo Aoki, Toshiyuki Shiraki, Shin-Ichi Higashijima, Hitoshi Okamoto

    Cell Reports     113916 - 113916  2024.03  [Refereed]  [International journal]

    Authorship：Lead author

    　View Summary

    The cortico-basal ganglia circuit mediates decision making. Here, we generated transgenic tools for adult zebrafish targeting specific subpopulations of the components of this circuit and utilized them to identify evolutionary homologs of the mammalian direct- and indirect-pathway striatal neurons, which respectively project to the homologs of the internal and external segment of the globus pallidus (dorsal entopeduncular nucleus [dEN] and lateral nucleus of the ventral telencephalic area [Vl]) as in mammals. Unlike in mammals, the Vl mainly projects to the dEN directly, not by way of the subthalamic nucleus. Further single-cell RNA sequencing analysis reveals two pallidal output pathways: a major shortcut pathway directly connecting the dEN with the pallium and the evolutionarily conserved closed loop by way of the thalamus. Our resources and circuit map provide the common basis for the functional study of the basal ganglia in a small and optically tractable zebrafish brain for the comprehensive mechanistic understanding of the cortico-basal ganglia circuit.

    DOI PubMed

    Scopus

    5
    Citation
    (Scopus)

  • The serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project to the dorsal pallium in zebrafish.

    Kotaro Shibayama, Haruna Nakajo, Yuki Tanimoto, Hisaya Kakinuma, Toshiyuki Shiraki, Takashi Tsuboi, Hitoshi Okamoto

    Neuroscience research    2024.03  [Refereed]  [International journal]

    　View Summary

    The serotonergic neurons in the raphe nucleus are implicated in various cognitive functions such as learning and emotion. In vertebrates, the raphe nucleus is divided into the dorsal raphe and the median raphe. In contrast to the abundance of knowledge on the functions of the dorsal raphe, the roles of the serotonergic neurons in the median raphe are relatively unknown. The studies using zebrafish revealed that the median raphe serotonergic neurons receive input from the two distinct pathways from the habenula and the IPN. The use of zebrafish may reveal the function of the Hb-IPN-median raphe pathway. To clarify the functions of the median raphe serotonergic neurons, it is necessary to distinguish them from those in the dorsal raphe. Most median raphe serotonergic neurons originate from rhombomere 2 in mice, and we generated the transgenic zebrafish which can label the serotonergic neurons derived from rhombomere 2. In this study, we found the serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project axons to the rostral dorsal pallium in zebrafish. This study suggests that this transgenic system has the potential to specifically reveal the function and information processing of the Hb-IPN-raphe-telencephalon circuit in learning.

    DOI PubMed

    Scopus

    1
    Citation
    (Scopus)

  • Neural mechanism of experience-dependent sensory gain control in C. elegans.

    Yosuke Ikejiri, Yuki Tanimoto, Kosuke Fujita, Fumie Hiramatsu, Shuhei J Yamazaki, Yuto Endo, Yasushi Iwatani, Koichi Fujimoto, Koutarou D Kimura

    Neuroscience research   191   77 - 90  2023.06  [Refereed]  [International journal]

    DOI PubMed

    Scopus

    3
    Citation
    (Scopus)

  • Calcium Imaging of Neuronal Activity under Gradually Changing Odor Stimulation in Caenorhabditis elegans.

    Yuki Tanimoto, Koutarou D Kimura

    Bio-protocol   11 ( 1 ) e3866  2021.01  [Refereed]  [Invited]  [International journal]

    Authorship：Lead author

    DOI PubMed

    Scopus

    3
    Citation
    (Scopus)

  • Neuronal, mathematical, and molecular bases of perceptual decision-making in C. elegans.

    Yuki Tanimoto, Koutarou D Kimura

    Neuroscience research   140   3 - 13  2019.03  [Refereed]  [Invited]  [International journal]

    Authorship：Lead author

    DOI PubMed

    Scopus

    11
    Citation
    (Scopus)

  • STEFTR: A Hybrid Versatile Method for State Estimation and Feature Extraction From the Trajectory of Animal Behavior.

    Shuhei J Yamazaki, Kazuya Ohara, Kentaro Ito, Nobuo Kokubun, Takuma Kitanishi, Daisuke Takaichi, Yasufumi Yamada, Yosuke Ikejiri, Fumie Hiramatsu, Kosuke Fujita, Yuki Tanimoto, Akiko Yamazoe-Umemoto, Koichi Hashimoto, Katsufumi Sato, Ken Yoda, Akinori Takahashi, Yuki Ishikawa, Azusa Kamikouchi, Shizuko Hiryu, Takuya Maekawa, Koutarou D Kimura

    Frontiers in neuroscience   13 ( JUN ) 626 - 626  2019  [Refereed]  [International journal]

    DOI PubMed

    Scopus

    10
    Citation
    (Scopus)

  • Calcium dynamics regulating the timing of decision-making in C. elegans.

    Yuki Tanimoto, Akiko Yamazoe-Umemoto, Kosuke Fujita, Yuya Kawazoe, Yosuke Miyanishi, Shuhei J Yamazaki, Xianfeng Fei, Karl Emanuel Busch, Keiko Gengyo-Ando, Junichi Nakai, Yuichi Iino, Yuishi Iwasaki, Koichi Hashimoto, Koutarou D Kimura

    eLife   6  2017.05  [Refereed]  [International journal]

    Authorship：Lead author

    DOI PubMed

    Scopus

    44
    Citation
    (Scopus)

  • In actio optophysiological analyses reveal functional diversification of dopaminergic neurons in the nematode C. elegans.

    Yuki Tanimoto, Ying Grace Zheng, Xianfeng Fei, Yukako Fujie, Koichi Hashimoto, Koutarou D Kimura

    Scientific reports   6   26297 - 26297  2016.05  [Refereed]  [International journal]

    Authorship：Lead author

    DOI PubMed

    Scopus

    26
    Citation
    (Scopus)

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Presentations

  • Basal ganglia output modulates behavioral stability for goal-directed state transition.

    Yuki Tanimoto, Makio Torigoe, Tanvir Islam, Hisaya Kakinuma, Toshiyuki Shiraki, Merlin Lange, Takuya Isomura, Hitoshi Okamoto

    International Symposium on the Unified Theory of Prediction and Action 2026 

    Presentation date： 2026.03

  • Future state prediction error activates pallidum output neurons to destabilize behavioral states for goal-directed state transition

    谷本悠生

    学術変革領域研究（A) 統一理論 第6回領域会議 、北海道大学 

    Presentation date： 2025.11

  • Future state prediction error activates pallidum output neurons to destabilize behavioral states for goal-directed state transition

    Yuki Tanimoto, Makio Torigoe, Islam Tanvir, Toshiyuki Shiraki, Hisaya Kakinuma, Merlin Lange, Takuya Isomura, Hitoshi Okamoto

    The 31st Japanese Medaka and Zebrafish Meeting 

    Presentation date： 2025.09

  • ゼブラフィッシュの大脳皮質－基底核回路による予測に基づいた意思決定機構

    谷本悠生  [Invited]

    脳科学における理論と実験の融合に向けた若手研究者セミナー2025 

    Presentation date： 2025.07

  • ゼブラフィッシュの大脳皮質－基底核回路による予測に基づいた意思決定機構

    谷本 悠生, 鳥越 万紀夫, イスラム タンビル, 白木 利幸, 柿沼 久哉, 岡本 仁

    第48回日本神経科学大会, 新潟 

    Presentation date： 2025.07

  • Future state prediction error activates pallidum output neurons to destabilize behavioral states for goal-directed state transition

    谷本悠生

    学術変革領域研究（A) 統一理論 第5回領域会議 、東京科学大学 

    Presentation date： 2025.05

  • Future state prediction error activates pallidum output neurons to destabilize behavioral states for goal-directed state transition

    Yuki Tanimoto, Makio Torigoe, Islam Tanvir, Toshiyuki Shiraki, Hisaya Kakinuma, Merlin Lange, Takuya Isomura, Hitoshi Okamoto

    Gordon Research Conferences, Modulation of Neural Circuits and Behavior 

    Presentation date： 2025.05

  • Future state prediction error activates pallidum output neurons to destabilize behavioral states for goal-directed state transition

    Yuki Tanimoto, Makio Torigoe, Islam Tanvir, Toshiyuki Shiraki, Hisaya Kakinuma, Merlin Lange, Takuya Isomura, Hitoshi Okamoto

    Gordon Research Seminars, Modulation of Neural Circuits and Behavior 

    Presentation date： 2025.05

  • Future state prediction error activates pallidum output neurons to destabilize behavioral states for goal-directed state transition

    Yuki Tanimoto, Makio Torigoe, Islam Tanvir, Toshiyuki Shiraki, Hisaya Kakinuma, Merlin Lange, Takuya Isomura, Hitoshi Okamoto

    Janelia Conference, Grounding Cognition in Mechanistic Insight 

    Presentation date： 2025.04

  • ゼブラフィッシュの大脳皮質−基底核回路の構造と機能の可視化手法

    谷本悠生  [Invited]

    Nikon小型魚類シリーズウェビナー第3回 

    Presentation date： 2025.01

  • A cortico-basal ganglia circuit mechanism for decision-making based on future state prediction error in goal directed behavior of adult zebrafish

    谷本悠生

    学術変革領域研究（A) 統一理論 第4回領域会議 、京都大学 

    Presentation date： 2024.11

  • A cortico-basal ganglia circuit mechanism for decision-making based on future state prediction error in goal directed behavior of adult zebrafish

    Yuki Tanimoto, Makio Torigoe, Islam Tanvir, Ryo Aoki, Toshiyuki Shiraki, Hisaya Kakinuma, Hitoshi Okamoto

    18th International Zebrafish Conference 

    Presentation date： 2024.08

  • Transgenic tools targeting the basal ganglia reveal both evolutionary conservation and specialization of neural circuits in zebrafish

    Yuki Tanimoto, Hisaya Kakinuma, Ryo Aoki, Toshiyuki Shiraki, Shin-ichi Higashijima, Hitoshi Okamoto

    NEURO2024 

    Presentation date： 2024.07

  • A cortico-basal ganglia circuit mechanism for decision-making based on future state prediction error in goal directed behavior of adult zebrafish

    谷本悠生

    学術変革領域研究（A) 統一理論 第３回領域会議, 理化学研究所 

    Presentation date： 2024.05

  • Transgenic tools targeting striatal and pallidal subpopulations have revealed evolutionary conservation and specialization of the cortico-basal ganglia circuit in zebrafish

    Tanimoto Y, Kakinuma H, Aoki R, Higashijima S, Okamoto H

    Zebrafish Neurobiology 2023, Cold Spring Harbor 

    Presentation date： 2023.11

  • A cortico-basal ganglia circuit mechanism for decision-making based on future state prediction error in goal directed behavior of adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    Zebrafish Neurobiology 2023, Cold Spring Harbor 

    Presentation date： 2023.11

  • A cortico-basal ganglia circuit mechanism for decision-making based on future state prediction error in goal directed behavior of adult zebrafish

    谷本悠生

    学術変革領域研究（A) 統一理論 第２回領域会議, OIST 

    Presentation date： 2023.11

  • A cortico-basal ganglia circuit mechanism for decision-making based on future state prediction error in goal directed behavior of adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    Presentation date： 2023.09

  • ゼブラフィッシュの大脳皮質−基底核回路による予測に基づいた意思決定機構

    谷本悠生, 鳥越万紀夫, イスラムタンビル, 青木亮, 白木利幸, 柿沼久哉, 岡本仁

    第46回日本神経科学大会, 仙台市 

    Presentation date： 2023.08

  • How do zebrafish predict the future and use the prediction for decision-making?

    Yuki Tanimoto

    Brain Medical Science Collaboration Division The 1st Joint Poster Presentation for Young Scientists 

    Presentation date： 2022.11

  • How do zebrafish predict the future and use the prediction for decision-making?

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    Presentation date： 2022.09

  • ゼブラフィッシュの大脳基底核における目標指向行動のための価値情報の機能的分離と統合

    谷本悠生, 鳥越万紀夫, イスラムタンビル, 青木亮, 白木利幸, 柿沼久哉, 岡本仁

    第45回日本神経科学大会（NEURO2022）, 宜野湾市 

    Presentation date： 2022.07

  • How do zebrafish predict the future and use the prediction for decision-making?

    Yuki Tanimoto  [Invited]

    Young Investigators' Seminar and Social 

    Presentation date： 2022.05

  • Learning of value information by the basal ganglia circuit in goal-directed behavior of adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    Presentation date： 2021.09

  • Learning of value information by the basal ganglia circuit in goal-directed behavior of adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Shiraki T, Kakinuma H, Okamoto H

    第44回日本神経科学大会, 神戸/オンライン 

    Presentation date： 2021.07

  • Basal ganglia output to cortex bi-directionally encodes positive and negative values for goal-directed behavior in adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Kakinuma H, Okamoto H

    11th European Zebrafish Meeting 2020, Czech 

    Presentation date： 2020.10

  • Basal ganglia output to cortex bi-directionally encodes positive and negative values for goal-directed decision-making in adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Kakinuma H

    Presentation date： 2020.07

  • Basal ganglia output to cortex encodes predictive information for goal-directed behavior in zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Kakinuma H, Okamoto H

    Presentation date： 2019.12

  • Calcium imaging of basal ganglia output to dorsal pallium during decision-making in adult zebrafish

    Tanimoto Y, Torigoe M, Islam T, Aoki R, Kakinuma H, Okamoto H

    Zebrafish Neural Circuits and Behavior 2019, Cold Spring Harbor 

    Presentation date： 2019.11

  • 意思決定中のゼブラフィッシュの大脳基底核―皮質経路の神経活動ダイナミクス

    谷本悠生, 鳥越万紀夫, イスラム タンビル, 青木亮, 柿沼久哉, 岡本仁

    Presentation date： 2019.07

  • 線虫C. elegansの嗅覚ナビゲーションにおける意思決定のための時間積分器の同定

    谷本 悠生

    第40回日本神経科学大会、千葉 

    Presentation date： 2017.07

  • Calcium dynamics regulates the timing of decision-making in worms

    Yuki Tanimoto

    21st International C. elegans Meeting, Los Angeles 

    Presentation date： 2017.06

  • 線虫C. elegans のIn actio光生理学的解析によるドーパミンニューロンの機能的分化の解明

    谷本 悠生

    第39回日本神経科学大会、横浜 

    Presentation date： 2016.07

  • In actio optophysiological analyses reveal functional diversification of dopaminergic neurons in the nematode C. elegans

    Tanimoto Y, Zheng YG, Fei X, Fujie Y, Hashimoto K, Kimura K

    CeNeuro2016, Nagoya 

    Presentation date： 2016.07

  • Neuronal mechanisms for C. elegans olfactory navigation revealed by a highly integrated microscope system

    Yuki Tanimoto

    20th International C. elegans Meeting, Los Angeles 

    Presentation date： 2015.06

  • Optophysiological dissection of individual dopaminergic neuron pairs during food-dependent behavioral modulation

    Yuki Tanimoto

    20th International C. elegans Meeting, Los Angeles 

    Presentation date： 2015.06

  • Neuronal mechanisms of decision making in C. elegans olfactory behavior revealed by a highly integrated microscope system

    Yuki Tanimoto

    The 37th Annual Meeting of the Japan Neuroscience Society 

    Presentation date： 2014.09

  • Neuronal mechanisms of decision making in C. elegans olfactory behavior revealed by a highly integrated microscope system.

    Yuki Tanimoto

    C. elegans Development Topic Meeting / Asia-Pacific C. elegans Meeting, Nara 

    Presentation date： 2014.07

  • A virtual reality running machine for worms‒a highly integrated microscope system for olfactory behavior

    Yuki Tanimoto

    19th International C. elegans Meeting, Los Angeles 

    Presentation date： 2013.06

  • A neuronal algorithm for sensory behavior in C. elegans revealed by a highly integrated microscope system

    Yuki Tanimoto

    Presentation date： 2013.06

  • 統合型解析顕微鏡システムの開発

    谷本 悠生

    包括型 脳科学研究推進支援ネットワーク夏のワークショップ、仙台 

    Presentation date： 2012.07

  • A virtual reality running machine for worms–a highly integrated tracking system for olfactory behavior

    Yuki Tanimoto

    5th East Asia C. elegans Meeting, Taipei 

    Presentation date： 2012.06

  • モデル動物 ・ 線虫C. elegansのシンプルな脳が働く仕組みを知りたい

    谷本 悠生  [Invited]

    2012年度 生物科学科 フレッシュマンリトリート 

    Presentation date： 2012.04

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Research Projects

  • ゼブラフィッシュの大脳皮質-基底核回路の光学的計測・操作による計算原理の実証

    日本学術振興会  科学研究費助成事業

    Project Year :

    2025.04
    -
    2027.03
     

    谷本 悠生

  • Functional analysis of cortico-basal ganglia circuit for prediction and decision-making in adult zebrafish

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research

    Project Year :

    2020.04
    -
    2023.03
     

    Tanimoto Yuki

    　View Summary

    Animals make appropriate decisions according to their surrounding environment. In this study, we used the compact cortico-basal ganglia circuit of adult zebrafish to image neural activity during prediction-based decision-making. We confirmed that learning-dependent predictive information appeared in the striatum, and that these predictive information were integrated in the output neurons in the zebrafish globus pallidus internus. Based on these results and ones previously obtained in our laboratory, we propose a computational model where the basal ganglia output destabilizes the cerebral cortex for transition of the behavioral states, which leads the fish to a learned appropriate sensory situation. This model provides a basic computational principle of the vertebrate cortico-basal ganglia circuit.

  • 統合型解析顕微鏡を用いた線虫C. elegansの感覚応答行動制御メカニズムの解明

    独立行政法人 日本学術振興会  特別研究員奨励費

    Project Year :

    2014.04
    -
    2017.03
     

    谷本 悠生

    　View Summary

    本研究では、「感覚入力に基づいて運動出力を制御する神経回路活動を、細胞レベルで理解すること」を目的とし、極めてシンプルな神経系を持つ線虫C. elegansをモデルとして、匂い物質ノナノンに対する濃度勾配に沿った効率的な忌避行動を可能にする神経メカニズムを明らかにする。これまでに我々は、独自に開発した統合型顕微鏡システムを用いて、ノナノンの増加と減少に反応する異なる二種類の感覚神経細胞を同定した。一種類の感覚細胞は濃度増加に対して微分的に活動し素早く方向転換を引き起こす一方、もう一種類の感覚細胞は濃度減少に積分的に反応し慎重に正しい方向への直進を引き起こしていた。さらに、この積分的な神経活動のパターンは、一種類の電位依存性カルシウムチャネルが持続的なカルシウム流入を引き起こすことで生成されることも明らかになった。今年度は、濃度増加に反応する細胞において、微分的活動が引き起こされるメカニズムを解明した。変異体や阻害剤を用いた解析と神経活動パターンの数理モデル化を組み合わせることで、この微分的活動は一過的な早い成分と積分的な遅い成分の和として表せられること、さらに、それぞれの成分を介する複数のカルシウムチャネルを同定した。以上から、細胞の種類依存的なカルシウムチャネルの関与が、神経細胞の応答性の速さを決定づけていることを明らかにした。

Misc

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Other

  • 第31回 小型魚類研究会 Oral Session 3 座長

    2025.09
    -