YAMADA, Seiya

写真a

Affiliation

Faculty of Human Sciences, School of Human Sciences

Job title

Research Associate

Education 【 display / non-display

  • 2020.04
    -
    Now

    Waseda University  

  • 2018.04
    -
    2020.03

    Waseda University  

  • 2014.04
    -
    2018.03

    早稲田大学   人間科学部   人間情報科学科  

Research Experience 【 display / non-display

  • 2021.04
    -
    Now

    Waseda University   Faculty of Human Sciences

  • 2020.04
    -
    2021.03

    日本学術振興会 特別研究員DC1

  • 2020.04
    -
    2021.03

    Waseda University

Professional Memberships 【 display / non-display

  • 2018.04
    -
    Now

    日本神経科学学会

  • 2017.04
    -
    Now

    日本分子生物学会

 

Research Areas 【 display / non-display

  • Molecular biology

  • Neuroscience-general

Research Interests 【 display / non-display

  • neural stem cell, neurogenesis, purinosome

Papers 【 display / non-display

  • Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development

    Seiya Yamada, Ayaka Sato, Hiroki Akiyama, Shin-ichi Sakakibara

    preprint, bioRxiv    2021.04

     View Summary

    <title>ABSTRACT</title>Brain development is a highly orchestrated process requiring spatiotemporally regulated mitochondrial dynamics. Drp1, a key molecule in the mitochondrial fission machinery, undergoes various post-translational modifications including conjugation to the small ubiquitin-like modifier (SUMO). However, the functional significance of SUMOylation/deSUMOylation on Drp1 remains controversial. SUMO-specific protease 5 (Senp5L) catalyzes the deSUMOylation of Drp1. We revealed that a splicing variant of Senp5L, Senp5S, which lacks peptidase activity, prevents deSUMOylation of Drp1 by competing against other Senps. The altered SUMOylation level of Drp1 induced by Senp5L/5S affects Drp1 ubiquitination and tubulation of the endoplasmic reticulum (ER), thereby influencing mitochondrial morphology. A dynamic SUMOylation/deSUMOylation balance controls neuronal polarization and migration during the development of the cerebral cortex. These findings suggest a novel role of post translational modification, in which a deSUMOylation enzyme isoform competitively regulates mitochondrial dynamics and ER tubulation via Drp1 SUMOylation levels in a tightly controlled process of neuronal differentiation and corticogenesis.

    DOI

  • Nwd1 Regulates Neuronal Differentiation and Migration through Purinosome Formation in the Developing Cerebral Cortex

    Seiya Yamada, Ayaka Sato, Shin-ichi Sakakibara

    iScience   23 ( 5 ) 101058 - 101058  2020.05

    DOI PubMed

  • Control of cell migration by the novel protein phosphatase-2A interacting protein inka2

    Hiroki Akiyama, Yumi Iwasaki, Seiya Yamada, Hiroyuki Kamiguchi, Shin-ichi Sakakibara

    Cell and Tissue Research   380 ( 3 ) 527 - 537  2020.01

    DOI

  • Expression profile of the STAND protein Nwd1 in the developing and mature mouse central nervous system

    Seiya Yamada, Shin-ichi Sakakibara

    Journal of Comparative Neurology (with cover page)   526 ( 13 ) 2099 - 2114  2018.09

    DOI

Awards 【 display / non-display

  • 小野梓記念賞 (学術賞)

    2020.03   早稲田大学  

    Winner: 山田晴也

  • 優秀発表賞

    2019.07   NEURO2019(第42回日本神経科学大会/第62回神経化学会大会)  

    Winner: 山田晴也, 秋山博紀, 榊原伸一

  • ジュニア研究者ポスター賞

    2018.07   第41回日本神経科学大会  

    Winner: 山田晴也, 秋山博紀, 榊原伸一

Research Projects 【 display / non-display

  • Nwd1遺伝子によるプリノソーム形成を介した新たな大脳皮質発生機構の解明

    Project Year :

    2020.04
    -
    2021.03
     

    山田晴也

    Authorship: Principal investigator

Presentations 【 display / non-display

  • The novel gene Nwd1 regulate cerebral cortex development

    Seiya Yamada, Hiroki Akiyama, Shin-ichi Sakakibara

    Presentation date: 2019.07

    Event date:
    2019.07