Details of a Researcher - NAKANISHI, Takuya

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NAKANISHI, Takuya

Scopus Paper Info

Paper Count: 83 Citation Count: 2708 h-index: 28

Click to view the Scopus page. The data was downloaded from Scopus API in December 20, 2024, via http://api.elsevier.com and http://www.scopus.com .

Affiliation

Research Council (Research Organization), Comprehensive Research Organization

Job title

Senior Researcher(Professor)

Degree

Doctor of Science ( Hokkaido University )

Research Experience

2022.07

-

Now

Waseda University Comprehensive Research Organization Senior Researcher (Professor)
2021.12

-

2022.06

National Institute for Materials Science (NIMS) Center for Green Research on Energy and Environmental Materials NIMS Special Researcher
2021.04

-

2021.11

Waseda University Comprehensive Research Organization Senior Researcher (Professor)
2019.04

-

2021.03

Waseda University Research Organization for Nano & Life Innovation Guest Senior Researcher (Guest Professor)
2017.11

-

2021.03

Waseda University Academic Solutions Corporation Project Planning and Development Dept. Supervisory Researcher/Consultant
2016.10

-

2017.10

National Institute of Advanced Industrial Science and Technology (AIST) Computational Bio Big-Data Open Innovation Laboratory Invited Researcher
2014.04

-

2016.09

Waseda University Institute for Nanoscience & Nanotechnology [reorganized as Research Organization for Nano & Life Innovation in 2015] Senior Researcher (Professor)
2013.04

-

2014.03

Waseda University Institute for Nanoscience & Nanotechnology Researcher (Associate Professor)
2009.04

-

2013.03

Waseda University Faculty of Science and Engineering Researcher (Associate Professor)
2005.04

-

2009.03

Waseda University Consolidated Research Institute for Advanced Science and Medical Care Visiting Associate Professor (full-time)
2004.09

-

2005.03

Waseda University Consolidated Research Institute for Advanced Science and Medical Care Visiting Lecturer (full-time)
2002.04

-

2004.08

JSPS Research Fellow (PD)
1998.09

-

2002.03

Waseda University Kagami Memorial Laboratory for Materials Science and Technology Visiting Research Associate

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Education Background

　

-

1998

Hokkaido University Graduate School of Science Division of Chemistry (Doctoral Course)
　

-

1995

Hokkaido University Graduate School of Science Division of Chemistry (Master's Course)
　

-

1993

Hokkaido University Faculty of Science Department of Chemistry

Committee Memberships

2016.07

-

2021.02

The Electrochemical Society of Japan Member of Public Relations Committee
2017.01

-

2017.05

2017 International Workshop on Electrified Interfaces for Energy Conversions (EIC2017), Organizing Committee Member
2014.12

-

2015.06

Symposium on Molecular Chirality 2015 (MC2015), Local Committee Member in Executive Committee
2013.03

-

2015.02

The Electrochemical Society of Japan Member of Convention Planning Committee
2013.10

-

2014.11

10th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT2014), Secretary General
2012.10

-

2013.07

12th Conference for BioSignal and Medicine (CBSM2013), Executive Committee Member
2011.03

-

2013.02

The Electrochemical Society of Japan Member of Editorial Committee
2010.03

-

2013.02

The Electrochemical Society of Japan Member of International Exchange Committee
2010.08

-

2011.09

The 62nd Annual Meeting of the International Society of Electrochemistry (62nd Annual ISE Meeting), Local Organizing Committee Member
2009.03

-

2011.02

The Electrochemical Society of Japan Secretary of Kanto Branch
2009.01

-

2009.05

12th Annual Meeting of Japanese Society for Marine Biotechnology, Executive Committee Member
2007.03

-

2009.02

The Electrochemical Society of Japan Member of Convention Planning Committee
2005.03

-

2007.02

The Electrochemical Society of Japan Councilor
2004.03

-

2006.02

The Electrochemical Society of Japan Secretary of Kanto Branch
2004.01

-

2004.10

5th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMT2004), Organizing Committee Member
1999.12

-

2000.11

The 5th Perpendicular Magnetic Recording Conference (PMRC2000), Member of Publication Division in Executive Committee
2000.04

-

2000.09

The 24th Annual Conference on Magnetics in Japan, Member of Local Secretariat in Executive Committee,
1999.01

-

1999.05

’99 Asian Conference on Electrochemistry ('99 ACEC), Organizing Committee Member

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Professional Memberships

　

　

　

The Japan Society of Vacuum and Surface Science
　

　

　

The Japan Society of Applied Physics
　

　

　

The Chemical Society of Japan
　

　

　

The Electrochemical Society of Japan

Research Areas

Functional solid state chemistry / Fundamental physical chemistry / Nanomaterials / Nanometer-scale chemistry

Research Interests

Characterization of Nanomaterials
Synthesis of Nanomaterials
Molecular Recognition
Films and Assemblies
Electrochemistry
Surfaces and Interfaces

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Awards

Poster Award, Chirality 2006 - 18th International Symposium on Chirality (ISCD-18)

2006.06
Best Poster Presentation Award, The 56th Annual Meeting of the International Society of Electrochemistry

2005.09
Poster Award, Chirality 2003 - 15th International Symposium on Chirality (ISCD-15)

2003.10

Papers

Wavelength dependence of linear birefringence and linear dichroism of Bi2−xPbxSr2CaCu2O8+δ single crystals

Keigo Tokita, Kenta Nakagawa, Kun Zhang, Komei Okano, Masataka Matsumoto, Takuya Nakanishi, Masaki Fujita, Toru Asahi

Scientific Reports 14 27102 2024.11 [Refereed] [International journal]

DOI

Scopus
Interaction between intrinsically disordered proteins Praja1 and α-synuclein on gold electrodes

Wataru Mori, Wataru Onodera, Terutoshi Kojima, Toru Asahi, Takuya Nakanishi

Chemistry Letters 53 ( 11 ) upae205 2024.11 [Refereed] [International journal]

Authorship：Last author, Corresponding author

DOI
Potential-Dependent and Face Orientation-Dependent Electrochemical Oxidative Desorption Behavior of Sulfur Species Adsorbed on Platinum Single-Crystal Surfaces

Tetsuro Morooka, Tamao Shishido, Ruttala Devivaraprasad, Ganesan Elumalai, Makoto Aoki, Tetsuroh Shirasawa, Takuya Nakanishi, Atsushi Ishikawa, Toshihiro Kondo, Takuya Masuda

Journal of Physical Chemistry C 128 ( 39 ) 16426 - 16436 2024.10 [Refereed] [International journal]

DOI

Scopus
Chiral Inversion of Thalidomide During Crystal Growth by Sublimation

Mizuki Kira, Yuta Shiga, Kenta Nakagawa, Ayaka Matsumoto, Keigo Tokita, Yukana Terasawa, Kun Zhang, Koichi Tsutao, Takuya Nakanishi, Satoshi Yoshida, Sota Sato, Norio Shibata, Toru Asahi

Crystal Growth & Design 24 ( 8 ) 3133 - 3139 2024.04 [Refereed] [International journal]

　View Summary

3′-(N-Phthalimido)glutarimide, commonly known as thalidomide (TD), is one of the most famous chiral drugs, because of its tragic history. Although the R-enantiomers of TD have positive medical effects, the S-enantiomers have dangerous side effects, and consequently, the enantiomeric purity of TD in a solid state and the chiral inversion of TD in physiological conditions have attracted considerable attention and prompted discussion on the “TD paradox”. Subsequently, the physicochemical properties of TD in the solid state have been indicated to be as essential as those in the solution state for understanding the pharmacodynamics and pharmacokinetics of TD. Herein, we demonstrate that the sublimation method is beneficial in the crystal growth of TD compared with solvent-evaporation methods. Structural and optical analyses demonstrated that sublimination produced very thin, transparent, and defect-free single crystals with high crystal-surface parallelism; chromatographic analysis suggested that a chiral inversion of TD molecules occurs during the sublimation even beneath the melting point under ambient humidity. The potential occurrence of chiral inversion of TD in the gas phase with atmospheric water vapor is a crucial finding in the use of sublimation in purifying chiral drugs to avoid adverse drug-induced outcomes. The crystal growth and potential chiral inversion of TD by sublimation should contribute to providing important information for pharmaceutical sciences and industry.

DOI

Scopus
Debonding-on-demand adhesives based on photo-reversible cycloaddition reactions

Moeka Inada, Tatsuhiro Horii, Toshinori Fujie, Takuya Nakanishi, Toru Asahi, Kei Saito

Materials Advances 4 ( 5 ) 1289 - 1296 2023.03 [Refereed] [International journal]

　View Summary

Debonding-on-demand (DoD) adhesives, which have the ability to repeatedly adhere and release in response to external stimuli, are attracting attention as sustainable functional materials. DoD adhesives can be designed by fabricating dynamic covalent bonds and using polymer cleavage and flow generation by dynamic mechanisms that respond autonomously to external stimuli, such as heat and light. However, the typical DoD adhesives using dynamic covalent bonds mainly utilize heat-induced systems, and the practical application of these adhesives at room temperature and ambient pressure is challenging. In this study, we report a DoD adhesive system based on a polymer that is fabricated by the reversible cycloaddition reaction of coumarin-terminated four-arm siloxane monomers. Thermophysical property analysis of the obtained polymers confirmed that photoinduced fluidization was based on the reversible crosslinking and decrosslinking reactions of the monomers. These thermophysical properties can directly control the stiffness of the polymers, providing mechanistic evidence of DoD adhesion. This simple siloxane-based reversible cycloaddition system exhibits significant potential as a DoD adhesive that functions at room temperature.

DOI
Improvement in long-term stability of field effect transistor biosensor in aqueous environments using a combination of silane and reduced graphene oxide coating

Sho Hideshima, Hiroki Hayashi, Ryo Takeuchi, Shofarul Wustoni, Shigeki Kuroiwa, Takuya Nakanishi, Toshiyuki Momma, Tetsuya Osaka

Microelectronic Engineering 264 111859 2022.08 [Refereed] [International journal]

DOI

Scopus

5

Citation

(Scopus)
New Trends in Nanoarchitectured SERS Substrates: Nanospaces, 2D Materials, and Organic Heterostructures

Olga Guselnikova, Hyunsoo Lim, Hyun Jong Kim, Sung Hyun Kim, Alina Gorbunova, Miharu Eguchi, Pavel Postnikov, Takuya Nakanishi, Toru Asahi, Jongbeom Na, Yusuke Yamauchi

Small 18 ( 25 ) 2107182 2022.06 [Refereed] [International journal]

　View Summary

This article reviews recent fabrication methods for surface-enhanced Raman spectroscopy (SERS) substrates with a focus on advanced nanoarchitecture based on noble metals with special nanospaces (round tips, gaps, and porous spaces), nanolayered 2D materials, including hybridization with metallic nanostructures (NSs), and the contemporary repertoire of nanoarchitecturing with organic molecules. The use of SERS for multidisciplinary applications has been extensively investigated because the considerably enhanced signal intensity enables the detection of a very small number of molecules with molecular fingerprints. Nanoarchitecture strategies for the design of new NSs play a vital role in developing SERS substrates. In this review, recent achievements with respect to the special morphology of metallic NSs are discussed, and future directions are outlined for the development of available NSs with reproducible preparation and well-controlled nanoarchitecture. Nanolayered 2D materials are proposed for SERS applications as an alternative to the noble metals. The modern solutions to existing limitations for their applications are described together with the state-of-the-art in bio/environmental SERS sensing using 2D materials-based composites. To complement the existing toolbox of plasmonic inorganic NSs, hybridization with organic molecules is proposed to improve the stability of NSs and selectivity of SERS sensing by hybridizing with small or large organic molecules.

DOI PubMed

Scopus

118

Citation

(Scopus)
Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles

Sho Hideshima, Hiroki Hayashi, Hiroshi Hinou, Shunsuke Nambuya, Shigeki Kuroiwa, Takuya Nakanishi, Toshiyuki Momma, Shin-Ichiro Nishimura, Yoshihiro Sakoda, Tetsuya Osaka

Scientific Reports 9 11616 2019.08 [Refereed] [International journal]

DOI PubMed

Scopus

34

Citation

(Scopus)
Effect of human serum on the electrical detection of amyloid-β fibrils in biological environments using azo-dye immobilized field effect transistor (FET) biosensor

Sho Hideshima, Shofarul Wustoni, Masumi Kobayashi, Hiroki Hayashi, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

Sensing and Bio-Sensing Research 17 25 - 29 2018.02 [Refereed] [International journal]

　View Summary

As amyloid-β peptide 1–42 (Aβ42) was found to be an emerging and important biomarker for Alzheimer's disease, the detection of this peptide in biological samples such as human serum (HS) has become very important for evaluating the potential disease state and determining the appropriate treatment. In this study, we developed an electrical analysis strategy based on a field effect transistor (FET) biosensor as a simple and reliable technique for confirming the presence of Aβ42 aggregates (fibrils) in biological samples. By utilizing Congo red immobilized on the FET gate surface as a biorecognition element, we observed remarkable sensitivity and specificity for detecting Aβ42 fibrils. Furthermore, we optimized the procedure to minimize the interference of abundant human serum albumin for the detection system using HS samples. The optimized system of Congo red-immobilized FET enables measurement of Aβ42 fibrils in the 100-pM level in HS samples, which is lower than its clinical concentration. The FET device can be applied as a biosensing system for mass and routine screening of peptide biomarkers related to Alzheimer's disease.

DOI

Scopus

16

Citation

(Scopus)
Multianalyte detection of cancer biomarkers in human serum using label-free field effect transistor biosensor

Ke Si, Shanshan Cheng, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

Sensors and Materials 30 ( 5 ) 991 - 999 2018 [Refereed] [International journal]

　View Summary

Recent statistics show that the incidence and mortality of cancer are on the rise. Among all types of cancer, lung cancer and liver cancer are the most prevalent. We have many biomarkers for these two cancers, among which the cytokeratin fragment 21-1 (CYFRA 21-1) and α-fetoprotein (AFP) are the most common and widely used. Among the various detection methods, the field effect transistor (FET) biosensor is one of the most attractive approaches, providing a label-free, fast, and low-cost electrical detection of biomarkers with high specificity and sensitivity. In previous work, we applied biomarkers for a single cancer type. With the detection of CYFRA 21-1 and neuron-specific enolase (NSE), lung cancer was differentiated in the early stages. Compared with the early work, the biomarkers for the two cancer types, CYFRA 21-1 for lung cancer and AFP for liver cancer, were prepared in this work. The detection of CYFRA 21-1 and AFP in human serum was achieved at the same time with the limits of detection of 1 and 10 ng mL−1, while the cut-off values were 4 and 10 ng mL−1. The method featured short analytical time, small sample volume, and low cost. With its good selectivity and appropriate sensitivity, clinical application will become popular in the future.

DOI

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14

Citation

(Scopus)
Label-free detection of allergens in food via surfactant-induced signal amplification using a field effect transistor-based biosensor

Sho Hideshima, Mai Saito, Keisuke Fujita, Yoshitaka Harada, Mika Tsuna, Satoshi Sekiguchi, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

Sensors and Actuators B: Chemical 254 1011 - 1016 2018.01 [Refereed] [International journal]

　View Summary

In recent years, food safety concerning food allergy has received increasing attention globally. A simple and sensitive detection method should be developed to measure trace amounts of allergens in foods. Here, we propose a label-free field effect transistor (FET)-based biosensing system for the detection of a buckwheat allergenic protein, BWp16, by surfactant-induced signal amplification. BWp16 could be detected by coupling with an anionic surfactant, sodium dodecyl sulfate (SDS), as this coupling enhanced the net charge of the protein, enough to be detected by FET biosensors. A significant response was observed when the allergen was coupled with SDS, while the responses were decreased or unchanged when it was coupled with a cationic or non-ionic surfactant, suggesting that the SDS coupling maintains the antibody recognition ability of the target allergen, and it would be useful to enhance the sensor responses. The fluorescence spectroscopic measurement revealed that the SDS molecules were successfully coupled with target allergenic protein BWp16, resulting in an increase in its net charge. Furthermore, we demonstrated that the FET biosensor enables specific detection of the allergen in food at the desired concentration levels for food safety analysis, suggesting that it could be used as an alternative food allergen analyzer, both industrially and domestically. (C) 2017 The Authors. Published by Elsevier B.V.

DOI

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32

Citation

(Scopus)
Effective induction of death in mesothelioma cells with magnetite nanoparticles under an alternating magnetic field

Shofu Matsuda, Eri Nakajima, Takuya Nakanishi, Airi Hitsuji, Hong Zhang, Akane Tanaka, Hiroshi Matsuda, Toshiyuki Momma, Tetsuya Osaka

Materials Science and Engineering: C 81 90 - 96 2017.12 [Refereed] [International journal]

　View Summary

With the objective of finding an avenue for development of magnetic hyperthermia as an effective mesothelioma treatment, the influence of heating by magnetite nanoparticles (MNPs) with a diameter of similar to 40 nm, which were incorporated into cells and then subjected to AC magnetic field, on induction of cell death was investigated in all three histological subtypes of human mesothelioma cells (i.e., epithelioid NCI-H28, sarcomatoid NCI-H2052, and biphasic MSTO-211H cells). Cellular uptake of MNPs was observed in all cell types, but the amount of MNPs incorporated per cell into MSTO-211H cells was smaller than in NCI-H28 and NCI-H2052 cells. On the other hand, cell death induced by cellular uptake of MNPs was observed specifically in MSTO-211H cells. Hence, when cells are heated by intracellular MNPs under AC magnetic field, a high degree of cell mortality in NCI-H28 and NCI-H2052 cells is induced by the temperature increase derived from the high amount of intracellular MNPs, but the combination of intracellular heating and cell-type-specific toxicity of MNPs induced high rates of cell death in MSTO-211H cells even at a lower temperature. Almost all of the heated cells were dead after 24-h incubation at 37 degrees C in all histological subtypes. Additionally, higher mortalities were observed in all three types of mesothelioma cells after MNPs-heating, as compared to the heating with a thermostatic bath. Herein, the significance of cellular uptake of MNPs for effectively inducing cell death in mesothelioma has been demonstrated in vitro. (C) 2017 Elsevier B.V. All rights reserved.

DOI PubMed

Scopus

9

Citation

(Scopus)
Review of Physiological Balance Sensing in an Unobtrusive Manner

Keishi Ohashi, Shigeki Kuroiwa, Sho Hideshima, Takuya Nakanishi, Tetsuya Osaka

Electronics and Communications in Japan 100 ( 9 ) 50 - 55 2017.09

　View Summary

The concept of unobtrusive physiological balance sensing system implementing biosensors is discussed. Biosensors connected with a data system are expected to play a significant role when we extend the sensing objects from body to mind and spirit. Here, we describe the unobtrusive monitoring system using field effect transistor-type sensors and wireless communication devices. Substances subject to the survey of our research will include small ions, immunoglobulins, and hormones. (C) 2017 Wiley Periodicals, Inc.

DOI

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1

Citation

(Scopus)
In Vitro Investigation of the Effect of Intracellular and Extracellular Magnetite Nanoparticles Subjected to Alternating Magnetic Field on MCF-7 Human Breast Cancer Cells

Takuya Nakanishi, Shofu Matsuda, Kisako Kaneko, Hong Zhang, Tetsuya Osaka

ChemistrySelect 1 ( 19 ) 6092 - 6102 2016.11 [Refereed] [International journal]

Authorship：Lead author

　View Summary

To evaluate the efficiency with which intra-and extracellular magnetite nanoparticles (MNPs) induce cell death under an alternating magnetic field (AMF), we comparatively investigated two systems consisting of MCF-7 human breast cancer cells and MNPs: one is a "simply-added" system, which is essentially a simple mixture of cells and extracellular MNPs, and the other is a "pre-cultivated" system that contains both intra-and extracellular MNPs. We also evaluated the effect of heating by thermostatic water bath (WB) on cell death in both systems. The degree of cell death was greater under heating with MNPs subjected to AMF than in the WB-heating in both systems. At higher doses of MNPs, the degree of cell death was greater in the "pre-cultivated" system than in the "simply-added" system using both heating methods. The cellular uptake of MNPs induced slight cell damage and caused a high degree of cell death at higher temperatures. A significant decrease in cell viability was observed in the presence of internalized MNPs under the AMF and was suggested to be a result of the combined effect of intracellular heating and cellular damage by MNPs.

DOI

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4

Citation

(Scopus)
Theoretical Study on the Formation Mechanism of Amino Acid-Cu(II) Complexes on an Enantio-Sensing Device Interface

Masahiro Kunimoto, Yusuke Sadaoka, Takuya Nakanishi, Tetsuya Osaka, Takayuki Homma

The Journal of Physical Chemistry C 120 ( 29 ) 15722 - 15728 2016.07 [Refereed] [International journal]

　View Summary

Theoretical analyses of L-alanine (L-Ala)- and L-homocysteine (L-Hcy)-Cu(II) complexes in basic, neutral, and acidic solutions were carried out using density functional theory to investigate the pH dependence of the formation mechanism of amino acid-Cu(II) complexes. The calculated complex formation energies indicate that the amino acid-Cu(II) complexes were expected to form in basic and neutral solutions but not in acidic solutions. The factors that determine the stability of these complexes are the coordination ability of each amino acid and the significance of intramolecular interactions among ligands within the complexes. As predicted from the molecular structure, in neutral solutions, the coordination ability of amino acid becomes lower than that in basic solutions because of the inert structure of the protonated amino group, -NH3+; however, the coordination ability originating from the -COO- group is estimated to be sufficient for stabilizing the entire complex system. Moreover, two H2O molecules coordinate with the central Cu2+ ion from the equatorial direction and interact with the coordinating amino acids, providing additional stability within the complex. In contrast, in acidic solutions, the complex does not have either sufficient coordination ability of amino acids or effective intramolecular interactions within the complex.

DOI

Scopus

3

Citation

(Scopus)
Conversion of protein net charge via chemical modification for highly sensitive prion detection using field effect transistor (FET) biosensor

Shofarul Wustoni, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Yasuro Mori, Tetsuya Osaka

Sensors and Actuators B: Chemical 230 374 - 379 2016.07 [Refereed] [International journal]

　View Summary

A robust and applicable strategy of signal amplification for field effect transistor (FET) biosensor is of scientifically and technologically importance to detect wide range of target molecules, particularly for the molecules of low charge density, and to configure highly sensitive analysis. In this communication, we demonstrate a simple technique to modify the net charge of target protein based on the concept of protein conjugation for the detection of prion, which is infectious and transmissible protein in neurodegenerative disorders. The increases of prion net charge after chemical modification generate signal amplification and have remarkably enhanced the sensitivity of FET biosensor below than femtomolar (fM) level. Thus, we suggest that such strategy is promising technique for achieving a highly sensitive detection at very low concentration that is useful for early determination of protein biomarkers. (C) 2016 Elsevier B.V. All rights reserved.

DOI

Scopus

5

Citation

(Scopus)
Signal amplification in electrochemical detection of buckwheat allergenic protein using field effect transistor biosensor by introduction of anionic surfactant

Sho Hideshima, Keisuke Fujita, Yoshitaka Harada, Mika Tsuna, Yasuhiro Seto, Satoshi Sekiguchi, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

Sensing and Bio-Sensing Research 7 90 - 94 2016.03 [Refereed] [International journal]

　View Summary

Food allergens, especially buckwheat proteins, sometimes induce anaphylactic shock in patients after ingestion. Development of a simple and rapid screening method based on a field effect transistor (FET) biosensor for food allergens in food facilities or products is in demand. In this study, we achieved the FET detection of a buckwheat allergenic protein (BWp16), which is not charged enough to be electrically detected by FET biosensors, by introducing additional negative charges from anionic surfactants to the target proteins. A change in the FET characteristics reflecting surface potential caused by the adsorption of target charged proteins was observed when the target sample was coupled with the anionic surfactant (sodium dodecyl sulfate
SDS), while no significant response was detected without any surfactant treatment. It was suggested that the surfactant conjugated with the protein could be useful for the charge amplification of the target proteins. The surface plasmon resonance analysis revealed that the SDS-coupled proteins were successfully captured by the receptors immobilized on the sensing surface. Additionally, we obtained the FET responses at various concentrations of BWp16 ranging from 1 ng/mL to 10 μg/mL. These results suggest that a signal amplification method for FET biosensing is useful for allergen detection in the food industry.

DOI

Scopus

15

Citation

(Scopus)
Review of physiological balance sensing in an unobtrusive manner

Keishi Ohashi, Shigeki Kuroiwa, Sho Hideshima, Takuya Nakanishi, Tetsuya Osaka

IEEJ Transactions on Sensors and Micromachines 136 ( 8 ) 357 - 361 2016 [Refereed]

　View Summary

The concept of unobtrusive physiological balance sensing system implementing biosensors is discussed. Biosensors connected with a data system is expected to play a significant role when we extend the sensing objects from body to mind and spirit. Here, we describe the unobtrusive monitoring system using FET-type sensors and wireless communication devices. Substances subject to the survey of our research will include small ions, immunoglobulins, and hormones.

DOI

Scopus
Synthesis of cobalt ferrite nanoparticles using spermine and their effect on death in human breast cancer cells under an alternating magnetic field

Shofu Matsuda, Takuya Nakanishi, Kisako Kaneko, Tetsuya Osaka

Electrochimica Acta 183 153 - 159 2015.11 [Refereed] [International journal]

　View Summary

To compare heat generation under an AC magnetic field for inducing cancer cell death, CoFe2O4 and Fe3O4 nanoparticles with a diameter of similar to 10 nm were synthesized by hydrolysis in an aqueous solution containing the metal chlorides iron(III) chloride and cobalt(II) or iron(II) chloride, with spermine or N,N'-bis(3-aminopropyl)butane-1,4-diamine, as a base and a protective reagent. Both CoFe2O4 and Fe3O4 nanoparticles were incorporated into human breast cancer MCF-7 cells; the nanoparticles exhibited little toxicity on the cells. When the cells containing nanoparticles were subjected to an AC magnetic field, MCF-7 cell death was induced by heat generated from similar to 10-nm CoFe2O4 nanoparticles but not from similar to 10-nm Fe3O4 nanoparticles. An increase in coercivity derived from the substitution of Fe2+ with Co2+ facilitated the ability of the nanoparticles to induce cell death in human breast cancer cells under an AC magnetic field. (C) 2015 Elsevier Ltd. All rights reserved.

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32

Citation

(Scopus)
Induction of Cell Death in Mesothelioma Cells by Magnetite Nanoparticles

Shofu Matsuda, Airi Hitsuji, Takuya Nakanishi, Hong Zhang, Akane Tanaka, Hiroshi Matsuda, Tetsuya Osaka

ACS Biomaterials Science & Engineering 1 ( 8 ) 632 - 638 2015.08 [Refereed] [International journal]

DOI
Label-free detection of tumor markers using field effect transistor (FET)-based biosensors for lung cancer diagnosis

Shanshan Cheng, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

Sensors and Actuators B: Chemical 212 329 - 334 2015.06 [Refereed] [International journal]

　View Summary

Detection of tumor markers is important for cancer diagnosis. Field effect transistor (FET) has been recognized as a powerful technique for label-free, sensitive, real-time, and multifunctional biosensing. Here, we developed FET biosensors that allow the label-free detection of cytokeratin fragment 21-1 (CYFRA 21-1) and neuron-specific enolase (NSE), useful tumor markers for lung cancer type differentiation. It was found that the FET biosensor was capable of quantitatively detecting these tumor markers in both phosphate-buffered saline and human serum. Additionally, we developed a multianalyte FET biosensor for the selective multiplexed detection of CYFRA 21-1 and NSE at the same time, by integrating two antibody types on the same chip, providing a step towards the realization of sensor arrays. The multianalyte FET biosensor, as described herein, will help for lung cancer differential diagnosis with advantages of simple and rapid detection procedures, low sample consumption, and low cost. (C) 2015 Elsevier B.V. All rights reserved.

DOI

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139

Citation

(Scopus)
Sensitive electrical detection of human prion proteins using field effect transistor biosensor with dual-ligand binding amplification

Shofarul Wustoni, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Masahiro Hashimoto, Yasuro Mori, Tetsuya Osaka

Biosensors and Bioelectronics 67 256 - 262 2015.05 [Refereed] [International journal]

　View Summary

Simple and accurate detection of prion proteins in biological samples is of utmost importance in recent years. In this study, we developed a label-free electrical detection-based field effect transistor (FET) biosensor using thiamine as a probe molecule for a non-invasive and specific test of human prion protein detection. We found that thiamine-immobilized FETs can be used to observe the prion protein oligomer, and might be a significant test for the early diagnosis of prion-related diseases. The thiamine-immobilized FET was also demonstrated for the detection of prion proteins in blood serum without any complex pre-treatments. Furthermore, we designed a dual-ligand binding approach by the addition of metal ions as a second ligand to bind with the adsorbed prion protein on the thiamine-immobilized surface. When the prion attached to metal ions, the additional positive charge was induced on the gate surface of the FET. This approach was capable of amplifying the magnitude of the FET response and of enhancing the sensitivity of the FET biosensor. Detection of prion proteins has achieved the required concentration for clinical diagnosis in blood serum, which is less than 2 nM. In summary, this FET biosensor was successfully applied to prion detection and proved useful as a simple, fast, sensitive and low-cost method towards a mass-scale and routine blood screening-based test. (C) 2014 Elsevier B.V. All rights reserved.

DOI

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29

Citation

(Scopus)
Label-free detection of Cu(II) in a human serum sample by using a prion protein-immobilized FET sensor

Shofarul Wustoni, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Yasuro Mori, Tetsuya Osaka

Analyst 140 ( 19 ) 6485 - 6488 2015 [Refereed] [International journal]

　View Summary

We have developed a field effect transistor (FET) sensor to sensitively detect copper ions (Cu2+) in a human serum (HS) sample for promising health-care diagnosis. By utilizing a Cu2+-binding prion protein that was immobilized on the FET gate surface, such an FET sensor can provide a simple, label free and highly selective performance, even in HS samples. We demonstrated the sensitivity of the sensor at the nanomolar level, 0-100 nM, which is very useful for the detection range of Cu2+ deficiency in practical applications.

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17

Citation

(Scopus)
Effects of chemical treatment of indium tin oxide electrode on its surface roughness and work function

Md. Zaved Hossain Khan, Takuya Nakanishi, Tetsuya Osaka

Surface and Coatings Technology 244 189 - 193 2014.04 [Refereed] [International journal]

Authorship：Lead author

　View Summary

In this paper, we report the effects of chemical treatment of indium tin oxide (ITO) surface on its surface chemistry such as chemical composition and surface roughness and on its usage as an electrode with monolayer modification. Atomic force microscopy, angel-resolved X-ray photoelectron spectroscopy, and Kelvin probe force microscopy have been used to investigate the morphology and the chemical properties of commercial thin ITO films after several treatments commonly used prior to the formation of organic layer on the surface. The amount of spike present on the surface of as-received ITO substrates was significantly reduced by etching with KOH whereas the roughness of ITO increased with HCI etching. We demonstrated that the successive treatment of ITO electrode with HCI and KOH affects the surface characteristics such as roughness and work function, contributing to the potentiometric detection of tiyptophan. (C) 2014 Elsevier B.V. All rights reserved.

DOI

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14

Citation

(Scopus)
Field Effect Transistor Biosensor Using Antigen Binding Fragment for Detecting Tumor Marker in Human Serum

Shanshan Cheng, Kaori Hotani, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Masahiro Hashimoto, Yasuro Mori, Tetsuya Osaka

Materials 7 ( 4 ) 2490 - 2500 2014.04 [Refereed] [International journal]

　View Summary

Detection of tumor markers is important for cancer diagnosis. Field-effect transistors (FETs) are a promising method for the label-free detection of trace amounts of biomolecules. However, detection of electrically charged proteins using antibody-immobilized FETs is limited by ionic screening by the large probe molecules adsorbed to the transistor gate surface, reducing sensor responsiveness. Here, we investigated the effect of probe molecule size on the detection of a tumor marker, alpha-fetoprotein (AFP) using a FET biosensor. We demonstrated that the small receptor antigen binding fragment (Fab), immobilized on a sensing surface as small as 2-3 nm, offers a higher degree of sensitivity and a wider concentration range (100 pg/mL-1 mu g/mL) for the FET detection of AFP in buffer solution, compared to the whole antibody. Therefore, the use of a small Fab probe molecule instead of a whole antibody is shown to be effective for improving the sensitivity of AFP detection in FET biosensors. Furthermore, we also demonstrated that a Fab-immobilized FET subjected to a blocking treatment, to avoid non-specific interactions, could sensitively and selectively detect AFP in human serum.

DOI

Scopus

73

Citation

(Scopus)
Effect of Synthetic Quartz Nanoparticle-Supported Counter Electrode on Dye-Sensitized Solar Cell

Shigeki Kuroiwa, Atsushi Kyan, Tomoko Ito, Nobuaki Komatsu, Takuya Nakanishi, Tetsuya Osaka

Electrochemistry 82 ( 3 ) 165 - 167 2014.03 [Refereed] [International journal]

DOI

Scopus
A label-free electrical assay of fibrous amyloid beta based on semiconductor biosensing

Sho Hideshima, Masumi Kobayashi, Takeyoshi Wada, Shigeki Kuroiwa, Takuya Nakanishi, Naoya Sawamura, Toru Asahi, Tetsuya Osaka

Chemical Communications 50 ( 26 ) 3476 - 3479 2014 [Refereed] [International journal]

　View Summary

We propose, as an alternative to conventional spectroscopic assays, a simple method for discriminating fibrous amyloid proteins by using a label-free semiconductor-based biosensor. The highly sensitive assay is expected to be useful for accelerating amyloid related research.

DOI

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15

Citation

(Scopus)
Monitoring Amyloid Sup35NM Growth with Label-Free Electrical Detection Using a Field-Effect Transistor Biosensor

Sho Hideshima, Shofarul Wustoni, Shigeki Kuroiwa, Takuya Nakanishi, Ayumi Koike-Takeshita, Tetsuya Osaka

ChemElectroChem 1 ( 1 ) 51 - 54 2014.01 [Refereed] [International journal]

DOI

Scopus

3

Citation

(Scopus)
Attomolar Detection of Influenza A Virus Hemagglutinin Human H1 and Avian H5 Using Glycan-Blotted Field Effect Transistor Biosensor

Sho Hideshima, Hiroshi Hinou, Daisuke Ebihara, Ryosuke Sato, Shigeki Kuroiwa, Takuya Nakanishi, Shin-Ichiro Nishimura, Tetsuya Osaka

Analytical Chemistry 85 ( 12 ) 5641 - 5644 2013.06 [Refereed] [International journal]

　View Summary

Influenza virus, through cell invasion and propagation with the interaction between hemagglutinin (HA) present on its surface and glycans on the host cell, causes a rapidly spreading infection throughout the world. In the present investigation, we succeeded for the first time in the attomolar-level sensing and discrimination of influenza A viral HA molecules H1 and H5 by using a glycan-immobilized field effect transistor (FET) biosensor. The small ligand glycans immobilized on the FET device, which make effective use of the charge-detectable region for FET-based detection in terms of Debye length, gave an advantage in the highly sensitive detection of the proteins. Two kinds of trisaccharides receptors terminating in sialic acid-alpha 2,6-galactose (6'-sialyllactose) and in sialic acid-alpha 2,3-galactose (3'-sialyllactose) were conjugated directly with the SiO2 surface of FET devices by a simple glycoblotting method using the self-assembled monolayer (SAM) of aminooxy terminated silane-coupling reagent, 3-aminooxypropyltriethoxysilane. Furthermore, it was demonstrated that the FETs with densely immobilized glycans, which possess the high capture ability by achieving the glycoside cluster effect, clearly distinguish HA molecules between their subtypes H1 (human) and H5 (avian) at the attomolar level, while the conventional method based on HA antibodies achieves only picomolar-level detection. Our findings indicate that the glycan-immobilized FET is a promising device to detect various pathogenic bacteria and viruses through glycan-protein interaction found ubiquitously in many infectious diseases.

DOI

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101

Citation

(Scopus)
Cytotoxicity evaluation of magnetite (Fe3O4) nanoparticles in mouse embryonic stem cells

Chigusa Shundo, Hong Zhang, Takuya Nakanishi, Tetsuya Osaka

Colloids and Surfaces B: Biointerfaces 97 221 - 225 2012.09 [Refereed] [International journal]

DOI

Scopus

44

Citation

(Scopus)
Detection of Matrix Metalloproteinase-2 by Field Effect Transistor with a Fibronectin-immobilized Gate

Daisuke Yamamoto, Sho Hideshima, Shigeki Kuroiwa, Takuya Nakanishi, Tetsuya Osaka

Chemistry Letters 41 ( 8 ) 825 - 827 2012.08 [Refereed] [International journal]

DOI

Scopus

2

Citation

(Scopus)
Effect of magnetite nanoparticles on living rate of MCF-7 human breast cancer cells

Daisuke Baba, Yasuhiro Seiko, Takuya Nakanishi, Hong Zhang, Atsushi Arakaki, Tadashi Matsunaga, Tetsuya Osaka

Colloids and Surfaces B: Biointerfaces 95 254 - 257 2012.06 [Refereed] [International journal]

DOI

Scopus

33

Citation

(Scopus)
Chiral sensing system based on the formation of diastereomeric metal complex on a homocysteine monolayer using field effect transistor

Daisuke Yamamoto, Takuya Nakanishi, Tetsuya Osaka

Electrochimica Acta 56 ( 26 ) 9652 - 9655 2011.11 [Refereed] [International journal]

DOI CiNii

Scopus

10

Citation

(Scopus)
Effect of surface roughness and surface modification of indium tin oxide electrode on its potential response to tryptophan

Md. Zaved Hossain Khan, Takuya Nakanishi, Shigeki Kuroiwa, Yoichi Hoshi, Tetsuya Osaka

Electrochimica Acta 56 ( 24 ) 8657 - 8661 2011.10 [Refereed] [International journal]

DOI CiNii

Scopus

10

Citation

(Scopus)
Potentiometric Detection of Serotonin, Melatonin, and Their Precursors/Metabolites with Monolayer-Modified Indium Tin Oxide Electrode and Their Concentration Dependency

Md. Zaved Hossain Khan, Takuya Nakanishi, Tetsuya Osaka

Sensor Letters 9 ( 5 ) 1849 - 1852 2011.10 [Refereed] [International journal]

DOI

Scopus

9

Citation

(Scopus)
Chiral discrimination between alanine enantiomers by field effect transistor with a homocysteine monolayer-modified gate

Mariko Matsunaga, Daisuke Yamamoto, Takuya Nakanishi, Tetsuya Osaka

Electrochimica Acta 55 ( 15 ) 4501 - 4505 2010.06 [Refereed] [International journal]

DOI CiNii

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20

Citation

(Scopus)
Potential Response of Monolayer-Modified Indium Tin Oxide Electrodes to Indole Compounds

Takuya Nakanishi, Tsubasa Ueno, Mariko Matsunaga, Md. Zaved Hossain Khan, Tetsuya Osaka

Electroanalysis 22 ( 4 ) 393 - 398 2010.02 [Refereed] [International journal]

Authorship：Lead author

DOI CiNii

Scopus

10

Citation

(Scopus)
New Proposal for the Interfacial Design toward the Establishment of Electrochemical Device Engineering

Tetsuya Osaka, Takuya Nakanishi

ELECTROCHEMICAL ENGINEERING FOR THE 21ST CENTURY (DEDICATED TO RICHARD C. ALKIRE) 28 ( 29 ) 17 - 24 2010 [Refereed] [International journal]

DOI

Scopus
Effect of surface charge of magnetite nanoparticles on their internalization into breast cancer and umbilical vein endothelial cells

Tetsuya Osaka, Takuya Nakanishi, Sangaraju Shanmugam, Shintaro Takahama, Hong Zhang

Colloids and Surfaces B: Biointerfaces 71 ( 2 ) 325 - 330 2009.07 [Refereed] [International journal]

DOI PubMed CiNii

Scopus

152

Citation

(Scopus)
Biosensing by optical waveguide spectroscopy based on localized surface plasmon resonance of gold nanoparticles used as a probe or as a label

Mayuki Kajiura, Takuya Nakanishi, Hironori Iida, Harumi Takada, Tetsuya Osaka

Journal of Colloid and Interface Science 335 ( 1 ) 140 - 145 2009.07 [Refereed] [International journal]

DOI PubMed CiNii

Scopus

29

Citation

(Scopus)
Tb3+-enhanced Potentiometric Detection of Single Nucleotide Polymorphism by Field Effect Transistors

Jinping Wang, Kenya Ito, Takuya Nakanishi, Shigeki Kuroiwa, Tetsuya Osaka

Chemistry Letters 38 ( 4 ) 376 - 377 2009.04 [Refereed] [International journal]

DOI CiNii

Scopus

6

Citation

(Scopus)
Controlled synthesis and magnetic properties of iron oxide nanostructures using biogenic polyamines

Sangaraju Shanmugam, Takuya Nakanishi, Tetsuya Osaka

ECS Transactions 16 ( 45 ) 189 - 197 2009 [Refereed] [International journal]

DOI

Scopus

6

Citation

(Scopus)
Morphology and Magnetic Properties of Iron Oxide Nanostructures Synthesized with Biogenic Polyamines

Sangaraju Shanmugam, Takuya Nakanishi, Tetsuya Osaka

Journal of The Electrochemical Society 156 ( 7 ) K121 - K127 2009 [Refereed] [International journal]

DOI CiNii

Scopus

8

Citation

(Scopus)
Preparation of Human Immune Effector T Cells Containing Iron-Oxide Nanoparticles

Hironori Iida, Kosuke Takayanagi, Takuya Nakanishi, Akiko Kume, Kouji Muramatsu, Yoshio Kiyohara, Yasuto Akiyama, Tetsuya Osaka

Biotechnology and Bioengineering 101 ( 6 ) 1123 - 1128 2008.12 [Refereed] [International journal]

DOI PubMed CiNii

Scopus

16

Citation

(Scopus)
Enantioselective potential response of a human serum albumin-modified ITO electrode for tryptophan

Mariko Matsunaga, Tsubasa Ueno, Takuya Nakanishi, Tetsuya Osaka

Electrochemistry Communications 10 ( 12 ) 1844 - 1846 2008.12 [Refereed] [International journal]

DOI CiNii

Scopus

24

Citation

(Scopus)
Preparation of FePt Nanoparticles with a Narrow Size Distribution in Ionic Liquids

Tetsuya Osaka, Takuma Hachisu, Atsushi Sugiyama, Izumi Kawakita, Takuya Nakanishi, Hironori Iida

Chemistry Letters 37 ( 10 ) 1034 - 1035 2008.10 [Refereed] [International journal]

DOI CiNii

Scopus

9

Citation

(Scopus)
Stereospecificity in redox reactions of catechins at gold electrodes modified with self-assembled monolayers of homocysteine

Takuya Nakanishi, Mariko Matsunaga, Makoto Nagasaka, Tsubasa Ueno, Tetsuya Osaka

Electrochimica Acta 53 ( 21 ) 6209 - 6214 2008.09 [Refereed] [International journal]

Authorship：Lead author

DOI

Scopus

14

Citation

(Scopus)
Effect of growth temperature on the shape and crystallinity of chemically produced FePt nanoparticles

Takuma Hachisu, Takahiro Yotsumoto, Atsushi Sugiyama, Hironori Iida, Takuya Nakanishi, Toru Asahi, Tetsuya Osaka

Chemistry Letters 37 ( 8 ) 840 - 841 2008.08 [Refereed] [International journal]

DOI CiNii

Scopus

9

Citation

(Scopus)
Effect of pH on the enantiospecificity of homocysteine monolayer on Au(111) for the redox reaction of 3,4-dihydroxyphenylalanine

Mariko Matsunaga, Makoto Nagasaka, Takuya Nakanishi, Takahiro Sawaguchi, Tetsuya Osaka

Electroanalysis 20 ( 9 ) 955 - 962 2008.05 [Refereed] [International journal]

DOI CiNii

Scopus

15

Citation

(Scopus)
Immobilization of gold nanoparticles on optical waveguides with organosilane monolayer

Takuya Nakanishi, Harumi Takada, Hironori Iida, Mayuki Kajiura, Tetsuya Osaka

Colloids and Surfaces A: Physicochemical and Engineering Aspects 313 234 - 238 2008.02 [Refereed] [International journal]

Authorship：Lead author

DOI

Scopus

2

Citation

(Scopus)
Organic molecular sensor with plasmon antenna

Masahiro Yanagisawa, Naonobu Shimamoto, Takuya Nakanishi, Mikiko Saito, Tetsuya Osaka

ECS Transactions 16 ( 11 ) 397 - 409 2008 [Refereed] [International journal]

DOI

Scopus

8

Citation

(Scopus)
Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis

Hironori Iida, Kosuke Takayanagi, Takuya Nakanishi, Tetsuya Osaka

Journal of Colloid and Interface Science 314 ( 1 ) 274 - 280 2007.10 [Refereed] [International journal]

DOI PubMed CiNii

Scopus

434

Citation

(Scopus)
Effect of surface coverage of gold(111) electrode with cysteine on the chiral discrimination of DOPA

Mariko Matsunaga, Takuya Nakanishi, Toru Asahi, Tetsuya Osaka

Chirality 19 ( 4 ) 295 - 299 2007.05 [Refereed] [International journal]

DOI

Scopus

23

Citation

(Scopus)
Highly enantioselective discrimination of amino acids using copper deposition on a gold electrode modified with homocysteine monolayer

Mariko Matsunaga, Takuya Nakanishi, Toru Asahi, Tetsuya Osaka

Electrochemistry Communications 9 ( 4 ) 725 - 728 2007.04 [Refereed] [International journal]

DOI CiNii

Scopus

33

Citation

(Scopus)
Origin of chiral discrimination by a two-dimensionally chiral self-assembled monolayer: A quantum chemical study

Tomohiro Nishikawa, Tsukasa Torimoto, Takuya Nakanishi, Tetsuya Osaka, Bunsho Ohtani

Chemical Physics Letters 432 ( 4-6 ) 502 - 507 2006.12 [Refereed] [International journal]

DOI CiNii

Scopus

2

Citation

(Scopus)
Preparation of magnetic iron-oxide nanoparticles by successive reduction-oxidation in reverse micelles: Effects of reducing agent and atmosphere

Hironori Iida, Takuya Nakanishi, Harumi Takada, Tetsuya Osaka

Electrochimica Acta 52 ( 1 ) 292 - 296 2006.10 [Refereed] [International journal]

DOI CiNii

Scopus

29

Citation

(Scopus)
Enantioselectivity of redox reaction of DOPA at the gold electrode modified with a self-assembled monolayer of homocysteine

Takuya Nakanishi, Mariko Matsunaga, Makoto Nagasaka, Toru Asahi, Tetsuya Osaka

Journal of the American Chemical Society 128 ( 41 ) 13322 - 13323 2006.10 [Refereed] [International journal]

Authorship：Lead author, Corresponding author

DOI PubMed CiNii

Scopus

54

Citation

(Scopus)
Crystallization of leucine on a self-assembled monolayer with covalently attached enantiomeric leucine molecules

Takuya Nakanishi, Naoki Banno, Mariko Matsunaga, Toru Asahi, Tetsuya Osaka

Colloids and Surfaces A: Physicochemical and Engineering Aspects 284 270 - 275 2006.08 [Refereed] [International journal]

Authorship：Lead author, Corresponding author

DOI

Scopus

12

Citation

(Scopus)
Effect of substrate morphology on the crystallization of leucine on gold surface modified with a self-assembled monolayer

Tetsuya Osaka, Mariko Matsunaga, Takuya Nakanishi, Toru Asahi, Naoki Banno

Chemistry Letters 35 ( 4 ) 438 - 439 2006.04 [Refereed] [International journal]

DOI CiNii

Scopus

3

Citation

(Scopus)
A Novel Approach for Preparation of gamma-Fe2O3 Nanoparticles: Successive Reduction-Oxidation in Reverse Micelles

Hironori Iida, Harumi Takada, Takuya Nakanishi, Tetsuya Osaka

The Electrochemical Society Proceeding Volumes PV 2004-23 325 - 329 2006 [Refereed] [International journal]
Application of a Two-phase Liquid-Liquid System to the Synthesis of Iron-Containing Nanoparticles

Takuya Nakanishi, Hironori Iida, Harumi Takada, Tetsuya Osaka

The Electrochemical Society Proceeding Volumes PV 2004-23 330 - 335 2006 [Refereed] [International journal]

Authorship：Lead author
Surface modification of gamma-Fe2O3 nanoparticles with aminopropylsilyl groups and interparticle linkage with alpha,omega-dicarboxylic acids

Hironori Iida, Takuya Nakanishi, Tetsuya Osaka

Electrochimica Acta 51 ( 5 ) 855 - 859 2005.11 [Refereed] [International journal]

DOI

Scopus

33

Citation

(Scopus)
Effects of additives on copper electrodeposition in submicrometer trenches

Madoka Hasegawa, Yoshinori Negishi, Takuya Nakanishi, Tetsuya Osaka

Journal of The Electrochemical Society 152 ( 4 ) C221 - C228 2005 [Refereed] [International journal]

DOI CiNii

Scopus

104

Citation

(Scopus)
Enantioselective crystal growth of leucine on a self-assembled monolayer with covalently attached leucine molecules

Naoki Banno, Takuya Nakanishi, Mariko Matsunaga, Toru Asahi, Tetsuya Osaka

Journal of the American Chemical Society 126 ( 2 ) 428 - 429 2004.01 [Refereed] [International journal]

Authorship：Corresponding author

DOI PubMed CiNii

Scopus

52

Citation

(Scopus)
Chiral discrimination between thalidomide enantiomers using a solid surface with two-dimensional chirality

Takuya Nakanishi, Naoko Yamakawa, Toru Asahi, Norio Shibata, Bunsho Ohtani, Tetsuya Osaka

Chirality 16 ( S1 ) S36 - S39 2004 [Refereed] [International journal]

Authorship：Lead author, Corresponding author

DOI

Scopus

45

Citation

(Scopus)
Preparation of iron oxide nanoparticles via successive reduction-oxidation in reverse micelles

Takuya Nakanishi, Hironori Iida, Tetsuya Osaka

Chemistry Letters 32 ( 12 ) 1166 - 1167 2003.12 [Refereed] [International journal]

Authorship：Lead author, Corresponding author

DOI CiNii

Scopus

30

Citation

(Scopus)
Influence of carbon inclusion on properties of electrodeposited CoNiFeMo thin films

Tokihiko Yokoshima, Asako Kawashima, Takuya Nakanishi, Tetsuya Osaka, Mikiko Saito, Keishi Ohashi

The Electrochemical Society Proceeding Volumes PV 2002-27 365 - 375 2003 [Refereed] [International journal]
Thermal desorption high-resolution mass spectrometry of mixed self-assembled monolayers on gold

Toshimichi Shibue, Takuya Nakanishi, Tomoka Matsuda, Toru Asahi, Tetsuya Osaka

Langmuir 18 ( 5 ) 1528 - 1534 2002.03 [Refereed] [International journal]

DOI CiNii

Scopus

13

Citation

(Scopus)
Enantioselective adsorption of phenylalanine onto self-assembled monolayers of 1,1 '-binaphthalene-2,2 '-dithiol on gold

Takuya Nakanishi, Naoko Yamakawa, Toru Asahi, Tetsuya Osaka, Bunsho Ohtani, Kohei Uosaki

Journal of the American Chemical Society 124 ( 5 ) 740 - 741 2002.02 [Refereed] [International journal]

Authorship：Lead author

DOI PubMed CiNii

Scopus

41

Citation

(Scopus)
All-Wet Barrier-Layer Fabricating Process on SiO2 for ULSI Cu Interconnections

Tetsuya Osaka, Tokihiko Yokoshima, Takuya Nakanishi

Proceedings of the Second International Conference on Semiconductor Technology 324 - 332 2002 [Refereed] [International journal]
Pulsed electrodeposition of nanocrystalline CoNiFe soft magnetic thin films

Takuya Nakanishi, Masaki Ozaki, Hyo-Seung Nam, Tokihiko Yokoshima, Tetsuya Osaka

Journal of The Electrochemical Society 148 ( 9 ) C627 - C631 2001.09 [Refereed] [International journal]

Authorship：Lead author

DOI CiNii

Scopus

52

Citation

(Scopus)
Effects of impurities on resistivity of electrodeposited high-B-s CoNiFe-based soft magnetic thin films

Tetsuya Osaka, Tokihiko Yokoshima, Takuya Nakanishi

IEEE Transactions on Magnetics 37 ( 4 ) 1761 - 1763 2001.07 [Refereed] [International journal]

DOI CiNii

Scopus

15

Citation

(Scopus)
Microstructure of electroplated soft magnetic CoNiFe thin films

Hyo-Seung Nam, Tokihiko Yokoshima, Takuya Nakanishi, Tetsuya Osaka, Yohtaro Yamazaki, Dong Nyung Lee

Thin Solid Films 384 ( 2 ) 288 - 293 2001.03 [Refereed] [International journal]

DOI CiNii

Scopus

44

Citation

(Scopus)
Fabrication of High-Bs Soft Magnetic Thin Film by an Electrodeposition Technique for Next-Generation Magnetic Recording Field

Tetsuya Osaka, Tokihiko Yokoshima, Takuya Nakanishi

The Electrochemical Society Proceeding Volumes PV 2000-29 167 - 175 2001 [Refereed] [International journal]
High-frequency permeability and thermal stability of electrodeposited high-B-s CoNiFe thin films

Satoshi Mizutani, Tokihiko Yokoshima, Hyo-Seung Nam, Takuya Nakanishi, Tetsuya Osaka, Yohtaro Yamazaki

IEEE Transactions on Magnetics 36 ( 5 ) 2539 - 2541 2000.09 [Refereed] [International journal]

DOI CiNii

Scopus

11

Citation

(Scopus)
Preparation and characterization of electrodeposited high-B-s CoNiFe thin films with high resistivity and improvement of their corrosion resistance

Manabu Kaseda, Masahiro Yamada, Takuya Nakanishi, Tetsuya Osaka

The Electrochemical Society Proceeding Volumes PV 99-34 263 - 272 2000 [Refereed] [International journal]
Preparation of Electrodeposited High-B_s and High-ρ CoNiFe Thin Films by Mo Addition

SOGAWA Y., KAWASHIMA A., YOKOSHIMA T., NAKANISHI T., NAM H.-S., OSAKA T., OHASHI K.

Journal of the Magnetics Society of Japan 24 ( 4-2 ) 699 - 702 2000 [Refereed]

DOI CiNii
Increasing the resistivity of electrodeposited high B-S CoNiFe thin film

Tokihiko Yokoshima, Manabu Kaseda, Masahiro Yamada, Takuya Nakanishi, Toshiyuki Momma, Tetsuya Osaka

IEEE Transactions on Magnetics 35 ( 5 ) 2499 - 2501 1999.09 [Refereed] [International journal]

DOI CiNii

Scopus

25

Citation

(Scopus)
Structure and photoelectrochemical properties of laminated monoparticle layers of CdS and ZnS on gold

Takuya Nakanishi, Bunsho Ohtani, Kohei Uosaki

Japanese Journal of Applied Physics 38 ( 1B ) 518 - 521 1999.01 [Refereed] [International journal]

Authorship：Lead author

DOI CiNii

Scopus

22

Citation

(Scopus)
Effect of immobilized electron relay on the interfacial photoinduced electron transfer at a layered inorganic-organic composite film on gold

Takuya Nakanishi, Bunsho Ohtani, Kohei Uosaki

Journal of Electroanalytical Chemistry 455 ( 1-2 ) 229 - 234 1998.09 [Refereed] [International journal]

Authorship：Lead author

DOI

Scopus

20

Citation

(Scopus)
Redox potential of Mo(VI)/Mo in alkali borate melts

Takuya Nakanishi, Hideki Maekawa, Toshio Yokokawa

Materials Transactions, JIM 39 ( 3 ) 399 - 403 1998.03 [Refereed] [International journal]

Authorship：Lead author

DOI

Scopus

7

Citation

(Scopus)
Fabrication and Characterization of CdS-Nanoparticle Mono- and Multilayers on a Self-Assembled Monolayer of Alkanedithiols on Gold

Takuya Nakanishi, Bunsho Ohtani, Kohei Uosaki

The Journal of Physical Chemistry B 102 ( 9 ) 1571 - 1577 1998 [Refereed] [International journal]

Authorship：Lead author

DOI CiNii

Scopus

195

Citation

(Scopus)
Layer-by-layer self-assembly of composite films of CdS nanoparticle and alkanedithiol on gold: an X-ray photoelectron spectroscopic characterization

Takuya Nakanishi, Bunsho Ohtani, Katsuaki Shimazu, Kohei Uosaki

Chemical Physics Letters 278 ( 4-6 ) 233 - 237 1997.10 [Refereed] [International journal]

Authorship：Lead author

DOI CiNii

Scopus

60

Citation

(Scopus)
Construction of Semiconductor Nanoparticle Layers on Gold by Self-Assembly Technique

Takuya Nakanishi, Bunsho Ohtani, Kohei Uosaki

Japanese Journal of Applied Physics 36 ( 6B ) 4053 - 4056 1997 [Refereed] [International journal]

Authorship：Lead author

DOI CiNii
Impedance of Electrode-Oxide Melts Containing Iron Oxide

Toshio Yokokawa, Takuya Nakanishi

The Electrochemical Society Proceeding Volumes PV 94-13 350 - 356 1994 [Refereed] [International journal]

DOI

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Books and Other Publications

Electrochemistry at the Nanoscale (Editors: Patrik Schmuki, Sannakaisa Virtanen)

Tetsuya Osaka, Takuya Nakanishi( Part： Contributor, "5.1 Oxide Nanoparticles" in "5 Nanoparticles" of "Electroless Fabrication of Nanostructures")

Springer 2009.01
第５版実験化学講座（日本化学会編）２５巻『触媒化学，電気化学』

中西卓也, 逢坂哲彌( Part： Contributor, 第６章３節３項「分子機能電極」)

丸善 2006.01
新訂版表面科学の基礎と応用（日本表面科学会編）

大谷文章, 中西卓也( Part： Contributor, 第３編（応用編）第７章（触媒材料の設計・作製および評価）第１節（設計表面）３項「二次元不斉表面」)

エヌティーエス 2004.06

Presentations

Modification of a Solid Surface using Self-Assembled Monolayers for Biosensors and Chiral Sensors

[Invited]

International Conference on Materials Science and Engineering 2021

Presentation date： 2021.10
Nanoscale Design and Preparation of Solid-Liquid Interfaces for Biosensors and Chiral Sensors

[Invited]

3rd DGIST-WASEDA Workshop on Electrochemistry

Presentation date： 2015.12
Synthesis of Magnetite Nanoparticles using Organic Amines and Evaluation for Biomedical Applications

[Invited]

The Catholic University of Korea & Waseda University 2nd Joint Symposium

Presentation date： 2015.11
電界効果トランジスタを利用したバイオセンサにおける固液ナノ界面

[Invited]

グリーンナノテクノロジー電極研究会「固液界面における物理化学と機能性界面物質相構築」ワークショップ

Presentation date： 2015.10
Design and Preparation of Nano-interfaces and Nano-materials for Biosensing and Biomedical Applications

[Invited]

International Symposium on Integration of Chemistry and Bioscience

Presentation date： 2014.01
高性能センサが導く健やかな暮らしと社会

[Invited]

タスクフォース「未来社会創成の会」第一回フォーラム

Presentation date： 2013.11
Development of Nano-interfaces and Nano-materials for Biosensing and Biomedical Applications

[Invited]

DGIST-WASEDA Workshop on Electrochemistry

Presentation date： 2013.08
Chiral Specificity in Chiral Molecular Monolayer and Its Application to Chiral Sensing for Small Molecules

12th Conference for BioSignal and Medicine (CBSM2013)

Presentation date： 2013.07
Synthesis of Magnetite Nanoparticles with Organic Amines and Evaluation of Their Properties for Biomedical Applications

[Invited]

International Conference of the Asian Union of Magnetic Societies (ICAUMS 2012)

Presentation date： 2012.10
Modification of Solid Surface with Self-Assembled Monolayer for Chiral Sensing

[Invited]

Pacific Rim Meeting on Electrochemical and Solid-State Science (PRiME 2012)

Presentation date： 2012.10
有機アミンを用いたマグネタイトナノ粒子の合成とそのバイオ・医療応用に向けた評価

[Invited]

日本磁気学会ナノバイオ磁気工学専門研究会・電気化学会ナノマイクロファブリケーション研究会・表面技術協会表協エレクトロニクス部会合同研究会

Presentation date： 2012.06
Effect of Surface Modification of Indium Tin Oxide Electrode on Its Potential Response to Tryptophan

The 62nd Annual Meeting of the International Society of Electrochemistry

Presentation date： 2011.09
Modification of Electrode Surface with Self-Assembled Monolayer for Analyte Recognition

[Invited]

2011 Korea-Waseda-Jilin Alliance Annual Symposium

Presentation date： 2011.06
Chiral Discrimination using a Self-Assembled Monolayer and Its Detection

[Invited]

The 2nd Symposium on Chiral Science & Technology: Mesochemistry & Chemical Wisdom

Presentation date： 2011.03
粒径を制御したマグネタイトナノ粒子の合成とそのバイオ・医療応用に向けた検討

[Invited]

電子通信情報学会磁気記録・情報ストレージ研究会

Presentation date： 2010.11
有機アミンを塩基に用いたマグネタイトナノ粒子の合成とそのバイオ分野への応用

[Invited]

2010年電気化学秋季大会

Presentation date： 2010.09
Chiral Sensing Based on the Formation of Diastereomeric Copper Complex on a Self-Assembled Monolayer of Homocysteine on Gold

The 7th Asian Conference on Electrochemistry (ACEC 2010)

Presentation date： 2010.05
Detection of Biotin-Streptavidin Reaction by Optical Waveguide Spectroscopy with Gold and Silver Nanoparticles

The 3rd Asian Conference on Colloid and Interface Science (ACCIS 2009)

Presentation date： 2009.10
Chiral Discrimination using a Self-Assembled Monolayer of Chiral Molecules

[Invited]

The Symposium on Chiral Science & Technology: Mesochemistry & Chemical Wisdom

Presentation date： 2009.09
New Trial on Nano Bio-Technology

[Invited]

7th International Symposium on Electrochemical Micro & Nanosystem Technologies (EMNT 2008)

Presentation date： 2008.09
Construction of New Biochips using Self-Assembled Monolayer

[Invited]

2008 Korean-Israeli Joint International Workshop on Cells-on-Chips

Presentation date： 2008.09
Biosensing by Optical Waveguide Spectroscopy with Gold Nanoparticles

ASMeW International Symposium

Presentation date： 2008.08
Chiral Recognition using Nanoscale Chiral Spaces in a Self-Assembled Monolayer on Gold

ASMeW International Symposium

Presentation date： 2008.08
Enantioselectivity of Redox Reaction of Catechins at the Gold Electrode Modified with a Self-Assembled Monolayer of Homocysteine

International Conference on Electrified Interfaces 2007 (ICEC 2007)

Presentation date： 2007.06
ナノ物質相による固体表面修飾とセンシングへの応用

[Invited]

表面技術協会表協エレクトロニクス部会・電気化学会情報機能材料研究会合同研究会

Presentation date： 2006.12
Immobilization of Gold Nanoparticles on Optical Waveguides with Organosilane Monolayer

Asian Conference on Nanoscience and Nanotechnology (AsiaNANO 2006)

Presentation date： 2006.11
Enantioselective Redox Reactions of Electrochemically-Active Chiral Molecules at the Gold Electrode Modified with Homocysteine

Chirality 2006 - 18th International Symposium on Chirality (ISCD-18)

Presentation date： 2006.09
有機単分子膜修飾界面でのキラル識別

[Invited]

第59回コロイドおよび界面化学討論会

Presentation date： 2006.09
自己組織化単分子膜によるキラル識別

[Invited]

北海道大学創成科学研究機構－早稲田大学先端科学・健康医療融合研究機構交流会

Presentation date： 2006.09
Chiral Discrimination using Self-Assembled Monolayers

[Invited]

Nanotechnology Joint Symposium between Waseda University and Shanghai Jiao Tong University

Presentation date： 2006.02
Synthesis of Iron and Iron-Alloy Nanoparticles in a Two-Phase Liquid-Liquid System

PACIFICHEM 2005 (The International Chemical Congress of Pacific Basin Societies)

Presentation date： 2005.12
単分子膜修飾表面におけるキラル識別

[Invited]

講演会「固液界面における物理化学と機能性界面物質相構築－最前線と未来展望－」

Presentation date： 2005.11
Enantioselective Redox Behavior of DOPA on Gold Electrode Modified with Homocysteine

The 56th Annual Meeting of the International Society of Electrochemistry

Presentation date： 2005.09
Crystallization of Leucine on a Self-Assembled Monolayer with Covalently Attached Enantiomeric Leucine Molecules

The 11th International Conference on Organized Molecular Films (LB11)

Presentation date： 2005.06
Synthesis of Iron-Containing Oxide Nanoparticles in Reverse Micelles

The 5th Asian Conference on Electrochemistry (ACEC 2005)

Presentation date： 2005.05
液液二相系を用いた鉄ナノ粒子の調製

電気化学会第72回大会

Presentation date： 2005.04
Application of a Two-phase Liquid-Liquid System to the Synthesis of Iron-Containing Nanoparticles

206th Meeting of The Electrochemical Society

Presentation date： 2004.10
Enantioselective Crystallization on Self-Assembled Monolayers and Its Application to Chiral Sensing

10th International Meeting on Chemical Sensors (10-IMCS)

Presentation date： 2004.07
自己組織化単分子膜修飾表面によるキラル認識

[Invited]

電気化学会関東支部第50回サイエンスレクチャー

Presentation date： 2004.07
自己組織化単分子膜修飾金基板上でのロイシン結晶化とそのキラル選択性

日本化学会第84春季年会

Presentation date： 2004.03
自己組織化単分子膜を用いたキラル認識

[Invited]

電気化学会第７回楽市フォーラムの会

Presentation date： 2004.02
Application of solid surfaces modified with self-assembled monolayers to the study of chiral discrimination

21COE International Symposium on 'Practical Nano-Chemistry'

Presentation date： 2003.12
Chiral Discrimination between Thalidomide Enantiomers by Using a Solid Surface with Two-Dimensional Chirality

Chirality 2003 - The 15th International Symposium on Chirality (ISCD-15)

Presentation date： 2003.10
軸不斉化合物自己組織化単分子膜のキラル認識場としての評価：サリドマイドのキラル選択的吸着

日本化学会第82秋季年会

Presentation date： 2002.09
自己組織化単分子層をシード層へ適用した無電解NiReP拡散防止層の作製と評価

電気化学会第69回大会

Presentation date： 2002.04
軸不斉化合物自己組織化単分子膜のキラル認識場としての評価：フェニルアラニンのキラル選択的吸着

日本化学会第81春季年会

Presentation date： 2002.03
軸不斉化合物自己組織化単分子膜修飾QCMによる光学活性アミノ酸吸着挙動の評価

電気化学会第68回大会

Presentation date： 2001.04
Pulsed-Current Electrodeposition of Soft Magnetic CoNiFe Thin Films

198th Meeting of The Electrochemical Society

Presentation date： 2000.10
Structural Characterization of Nanocrystalline CoNiFe Thin Films Prepared by Pulsed Electrodeposition

International Symposium on Electrochemistry of Ordered Interface 2000

Presentation date： 2000.08
パルス電析法によるCoNiFe軟磁性薄膜の作製

電気化学会第67回大会

Presentation date： 2000.04
Preparation and Characterization of High Bs Soft Magnetic Films by Plating Method

[Invited]

The 50th Annual Meeting of International Society of Electrochemistry

Presentation date： 1999.09
Fabrication, Structure, and Photoelectrochemical Properties of Semiconductor-Nanoparticle Monolayers Attached on Gold using Self-Assembled Monolayers of Dithiols

2nd International Symposium on Electrochemical Microsystem Technologies

Presentation date： 1998.09
半導体超微粒子を用いた光機能性表面の創製

[Invited]

電気化学会北海道支部第16回ライラックセミナー・第5回若手研究者交流会

Presentation date： 1998.06
Fabrication and Characterization of Semiconductor-Particle Monolayers Attached on a Self-Assembled Monolayer of Alkanedithiol

215th American Chemical Society National Meeting

Presentation date： 1998.03
ZnS超微粒子および機能分子と複合化したCdS超微粒子層膜の調製と特性評価

日本化学会北海道支部1998年冬季研究発表会

Presentation date： 1998.02
CdS超微粒子／アルカンジチオール交互累積層の構造と光機能

日本化学会第73秋季年会

Presentation date： 1997.09
CdS超微粒子／アルカンジチオール交互累積層膜の調製と特性

電気化学会第64回大会

Presentation date： 1997.03
自己組織化法によるCdS超微粒子／ジチオール複合層の構築

日本化学会北海道支部1997年冬季研究発表会

Presentation date： 1997.02
Construction of Semiconductor Nanoparticle Layers on Gold by Self-Assembly Technique

QDS '96 (1996 International Symposium on Formation, Physics and Device Application of Quantum Dot Structures)

Presentation date： 1996.11
溶融ほう酸塩のインピーダンス解析－電気伝導度および酸素電極反応－

第26回溶融塩化学討論会

Presentation date： 1994.11
酸化物融体と金属系のインピーダンス（第4報）：酸化鉄の寄与

日本金属学会1994年春期(第114回)大会

Presentation date： 1994.03
酸化物融体-電極界面のインピーダンス測定

平成5年度冬季日本金属学会・日本鉄鋼協会両北海道支部講演大会

Presentation date： 1994.01
スラグの酸化還元とインピーダンス（III）

日本金属学会1993年秋期(第113回)大会

Presentation date： 1993.10
Na2O-B2O3系融体中におけるMoイオンの酸化還元挙動

第19回電気化学協会北海道支部研究発表会

Presentation date： 1993.01

▼display all

Research Projects

Establishment of Electrochemical Device Engineering

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research

Project Year :

2008

-

2012

OSAKA Tetsuya, MOMMA Toshiyuki, SHOJI Shuichi, SUGIYAMA Atsushi, NAKANISHI Takuya, HOMMA Takayuki, MATSUKATA Masahiko, MIZUNO Jun, SEKIGUCHI Tetsushi, YOSHINO Masahiro, TOMINAKA Satoshi

　View Summary

Based on the researches for development of functional materials with the control of solid-liquid interface and for development of devices with the practical use of nano- and meso-structures and phenomena at the interface, the establishment of Electrochemical Device Engineering was promoted. To establish Electrochemical Device Engineering on the basis of Electrochemical Nanotechnology, the practical devices utilizing the outcome of research and the dimensions for appearance of function and design of solid-liquid interface were set as the warp and weft of this academic discipline.
自己組織化単分子膜によるキラル識別とその効果的検出法の開発

東京応化科学技術振興財団第24回研究費の助成

Project Year :

2010.04

-

2011.03
超高密度磁気記録用軟磁性薄膜の電気化学的作製とナノ構造制御による高機能発現

日本学術振興会科学研究費助成事業

Project Year :

2002

-

2004

中西卓也

Misc

α-アミラーゼアプタマー固定化電界効果トランジスタ型バイオセンサーの作製とα-アミラーゼの検出

松坂朱峰, 秀島翔, 金子直人, 堀井克紀, 和賀巌, 黒岩繁樹, 中西卓也, 大橋啓之, 門間聰之, 逢坂哲彌

日本化学会春季年会講演予稿集(CD-ROM) 97th 2017

J-GLOBAL
GRAPHENE OXIDE COATING ON GATE INSULATOR OF FIELD EFFECT TRANSISTOR BIOSENSOR FOR IMPROVEMENT OF ITS LONG-TERM STABILITY DURING STORAGE IN SOLUTION

竹内亮, 秀島翔, 黒岩繁樹, 中西卓也, 門間聰之, 逢坂哲彌, 逢坂哲彌

Chemical Sensors 33 ( Supplement B ) 2017

J-GLOBAL
MgFe₂O₄ナノ粒子の合成と交流磁場下での発熱によるヒト乳がん細胞の死滅誘導

金津真帆, 松田翔風, 中西卓也, 柏俣佑果, 門間聰之, 逢坂哲彌

日本磁気学会学術講演概要集 40th 2016

J-GLOBAL
電界効果トランジスタを用いたタンパク質検出に界面活性剤処理が及ぼす影響

齊藤真衣, 藤田圭祐, 秀島翔, 原田義孝, 綱美香, 黒岩繁樹, 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集(CD-ROM) 83rd 2016

J-GLOBAL
磁気ハイパーサーミア応用へ向けた銅亜鉛フェライトナノ粒子の合成と特性評価

宮崎航大, 松田翔風, 中西卓也, 門間聰之, 逢坂哲彌

粉体粉末冶金協会講演概要集 2016 2016

J-GLOBAL
電界効果トランジスタ(FET)センサを用いたソバ16kDアレルゲンタンパク質の非標識高感度検出

原田義孝, 綱美香, 藤田圭祐, 秀島翔, 黒岩繁樹, 中西卓也, 逢坂哲彌, 逢坂哲彌

日本農芸化学会大会講演要旨集(Web) 2016 2016

J-GLOBAL
EFFECT OF SURFACTANT TREATMENT ON PROTEIN DETECTION USING FIELD EFFECT TRANSISTOR

齊藤真衣, 藤田圭祐, 秀島翔, 原田義孝, 綱美香, 黒岩繁樹, 中西卓也, 逢坂哲彌, 逢坂哲彌

Chemical Sensors 32 ( Supplement A ) 2016

J-GLOBAL
ELECTROCHEMICAL MICRO & NANOSYSTEM TECHNOLOGIES Foreword

Tetsuya Osaka, Takuya Nakanishi

ELECTROCHIMICA ACTA 183 1 - 2 2015.11

Other

DOI
PtCu電析とCu脱合金化による色素増感太陽電池用高表面積Pt電極の作製

田中俊, 黒岩繁樹, 中西卓也, 逢坂哲彌, 逢坂哲彌

電気化学会大会講演要旨集(CD-ROM) 82nd 2015

J-GLOBAL
DETECTION OF HEMAGGLUTININ DISSOCIATED FROM INFLUENZA VIRUS USING GLYCAN-IMMOBILIZED FIELD EFFECT TRANSISTOR

南部谷俊介, 前川達洋, 秀島翔, 比能洋, 西村紳一郎, 迫田義博, 黒岩繁樹, 中西卓也, 逢坂哲彌, 逢坂哲彌

Chemical Sensors 31 ( Supplement A ) 2015

J-GLOBAL
糖鎖固定化電界効果トランジスタによるインフルエンザウイルスから分離したヘマグルチニンの検出

南部谷俊介, 前川達洋, 秀島翔, 比能洋, 西村紳一郎, 迫田義博, 黒岩繁樹, 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集(CD-ROM) 82nd 2015

J-GLOBAL
上皮型及び混合型中皮腫細胞にマグネタイトナノ粒子の取り込みと交流磁場印加が及ぼす影響

中嶋恵里, 松田翔風, 中西卓也, 張弘, 田中あかね, 松田浩珍, 逢坂哲彌, 逢坂哲彌

日本生化学会大会(Web) 88th 2015

J-GLOBAL
細胞内および細胞外に存在するマグネタイト粒子の発熱がヒト乳がん細胞に与える死滅効果

金子恭彩子, 松田翔風, 中西卓也, 張弘, 逢坂哲彌, 逢坂哲彌

日本生化学会大会(Web) 88th 2015

J-GLOBAL
マグネタイトナノ粒子の発熱がヒト乳がん細胞MCF-7の生存率に及ぼす影響のin vitro評価

金子恭彩子, 松田翔風, 中西卓也, ZHANG Hong, 逢坂哲彌, 逢坂哲彌

日本分子生物学会年会プログラム・要旨集(Web) 37th 2014

J-GLOBAL
マグネタイトナノ粒子を取り込んだ中皮腫細胞への交流磁場照射が細胞死に与える影響

日辻愛理, 松田翔風, 中西卓也, ZHANG Hong, 逢坂哲彌, 逢坂哲彌

日本分子生物学会年会プログラム・要旨集(Web) 37th 2014

J-GLOBAL
電折・脱合金化法による色素増感太陽電池用高表面積白金電極の作製

喜屋武厚, 黒岩繁樹, 中西卓也, 逢坂哲彌, 逢坂哲彌

電気化学秋季大会講演要旨集 2013 2013

J-GLOBAL
マグネタイトナノ粒子の取り込みがマウスマクロファージの機能に及ぼす影響

筒井菜々子, 張弘, 中西卓也, 田中あかね, 松田浩珍, 逢坂哲彌, 逢坂哲彌

日本分子生物学会年会プログラム・要旨集(Web) 36th 2013

J-GLOBAL
DETECTION OF AMYLOID β WITH DIFFERENT AGGREGATE MORPHOLOGY BY USING FIELD EFFECT TRANSISTORS

小林万純, 秀島翔, 黒岩繁樹, 中西卓也, 澤村直哉, 朝日透, 朝日透, 逢坂哲彌, 逢坂哲彌

Chemical Sensors 29 ( Supplement A ) 2013

J-GLOBAL
中皮腫細胞へのマグネタイトナノ粒子の取り込みとその交流磁場下での発熱による細胞死の評価

日辻愛理, 松田翔風, 中西卓也, ZHANG H., 田中あかね, 松田浩珍, 逢坂哲彌

電気化学会大会講演要旨集 80th 2013

J-GLOBAL
DETECTION OF MATRIX METALLOPROTEINASE-2 BY FIELD EFFECT TRANSISTOR UTILIZING DEGRADATION OF FIBRONECTIN

山本大輔, 秀島翔, 黒岩繁樹, 中西卓也, 逢坂哲彌

Chemical Sensors 29 ( Supplement A ) 2013

J-GLOBAL
フィブロネクチンの分解反応を利用したマトリックスメタロプロテアーゼ-2のFETによる検出

山本大輔, 秀島翔, 黒岩繁樹, 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集 80th 2013

J-GLOBAL
電界効果トランジスタを用いた凝集形態の異なるアミロイドβの検出

小林万純, 秀島翔, 黒岩繁樹, 中西卓也, 澤村直哉, 朝日透, 逢坂哲彌, 朝日透, 逢坂哲彌

電気化学会大会講演要旨集 80th 2013

J-GLOBAL
腫瘍マーカーの電気的検出におけるプローブ分子小型化による高感度化

宝谷佳織, 程サンサン, 秀島翔, 黒岩繁樹, 中西卓也, 逢坂哲彌, 逢坂哲彌

日本分子生物学会年会プログラム・要旨集(Web) 36th 2013

J-GLOBAL
マグネタイトナノ粒子の中皮腫細胞への取り込みとその発熱による細胞死の評価

日辻愛理, 松田翔風, 中西卓也, 張弘, 田中あかね, 松田浩珍, 逢坂哲彌, 逢坂哲彌

日本分子生物学会年会プログラム・要旨集(Web) 36th 2013

J-GLOBAL
Field Effect Transistor Based Micro Sensors ―pH Sensors and Biosensors―

Tetsuya Osaka, Shigeki Kuroiwa, Sho Hideshima, Takuya Nakanishi

Chemical Sensors 28 ( 1 ) 8 - 15 2012.03 [Refereed]

Article, review, commentary, editorial, etc. (scientific journal)

CiNii J-GLOBAL
マウスマクロファージによるマグネタイトナノ粒子取り込み挙動の評価

筒井菜々子, ZHANG Hong, 中西卓也, 田中あかね, 松田浩珍, 逢坂哲彌

日本分子生物学会年会プログラム・要旨集(Web) 35th 2012

J-GLOBAL
中皮腫細胞へのマグネタイトナノ粒子の取り込みと細胞毒性作用

松田翔風, ZHANG Hong, 中西卓也, 田中あかね, 松田浩珍, 逢坂哲彌

日本分子生物学会年会プログラム・要旨集(Web) 35th 2012

J-GLOBAL
ポリエチレンイミン修飾マグネタイトナノ粒子のヒト由来乳がん細胞及び正常ヒト臍帯血細胞に対する取り込みの評価

清古康弘, 馬場大輔, ZHANG H., 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集 79th 2012

J-GLOBAL
マグネタイトナノ粒子の中皮腫細胞への取り込み及び殺傷効果の評価

松田翔風, 馬場大輔, ZHANG H., 中西卓也, 田中あかね, 松田浩珍, 逢坂哲彌

電気化学会大会講演要旨集 79th 2012

J-GLOBAL
リジン脱炭酸酵素固定化電界効果トランジスタによるL-リジンの検出

井上智之, 山本大輔, 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集 78th(CD-ROM) 2011

J-GLOBAL
スペルミンを用いて合成した粒子径の異なるマグネタイトナノ粒子の磁性および発熱特性の評価

馬場大輔, 清古康弘, ZHANG H., 新垣篤史, 中西卓也, 松永是, 逢坂哲彌

電気化学会大会講演要旨集 78th(CD-ROM) 2011

J-GLOBAL
ポリエチレンイミン修飾マグネタイトナノ粒子の発熱によるがん細胞の死滅評価

清古康弘, 馬場大輔, ZHANG H., 新垣篤史, 中西卓也, 松永是, 逢坂哲彌

電気化学会大会講演要旨集 78th(CD-ROM) 2011

J-GLOBAL
DETECTION OF L-LYSINE USING FIELD EFFECT TRANSISTOR WITH LYSINE DECARBOXYLASE IMMOBILIZED ON THE GATE

井上智之, 山本大輔, 中西卓也, 逢坂哲彌

Chemical Sensors 27 ( Supplement A ) 2011

J-GLOBAL
DETECTION OF L-LYSINE USING FIELD EFFECT TRANSISTOR WITH LYSINE OXIDASE IMMOBILIZED ON THE GATE

井上智之, 佐藤絵美子, 中西卓也, 逢坂哲彌

Chemical Sensors 27 ( Supplement B ) 2011

J-GLOBAL
Size-tuned synthesis of magnetite nanoparticles and their biomedical application

ITE technical report 34 ( 50 ) 13 - 15 2010.11

CiNii
Size‐tuned Synthesis of Magnetite Nanoparticles and Their Biomedical Application

Takuya Nakanishi, Hong Zhang, Tetsuya Osaka

IEICE Technical Report (Institute of Electronics, Information and Communication Engineers) 110 ( 310(MR2010 34-41) ) 13 - 15 2010.11 [Invited]

J-GLOBAL
Safety of magnetite nanoparticles into mouse embryonic stem cells

春藤千草, ZHANG Hong, 中西卓也, 逢坂哲彌

生化学 2010

J-GLOBAL
ホモシステイン単分子膜修飾FETを用いた種々のアミノ酸のキラル識別

山本大輔, 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集 77th 2010

J-GLOBAL
有機アミンを塩基に用いたマグネタイトナノ粒子の合成とそのバイオ分野への応用

中西卓也, ZHANG Hong, 逢坂哲彌

電気化学秋季大会講演要旨集 2010 2010

J-GLOBAL
発熱効率向上を目的としたマグネタイトナノ粒子の粒径及び分散性の制御

馬場大輔, 新垣篤史, 中西卓也, 松永是, 逢坂哲彌

日本磁気学会学術講演概要集 34th 2010

J-GLOBAL
人工ホットスポットを用いたSAM膜のラマン検出

柳沢雅広, 島本直伸, 中西卓也, 齋藤美紀子, 逢坂哲彌, 上野太郎, 船津高志

応用物理学関係連合講演会講演予稿集 55th ( 3 ) 2008

J-GLOBAL
同心円プラズモンアンテナ型分子センサーの設計と表面増強ラマン散乱による分子の検出

柳沢雅広, 中西卓也, 梶浦真由紀, 島本直伸, 齋藤美紀子, 会田敏之, 加藤邦男, 逢坂哲彌

表面科学学術講演会講演要旨集 28th 2008

J-GLOBAL
電気化学界面でのSAMを利用したキラル認識システム

逢坂哲彌, 逢坂哲彌, 中西卓也, 松永真理子

表面科学学術講演会講演要旨集 28th 2008

J-GLOBAL
イオン液体を溶媒とするFePtナノ粒子の化学的合成

蜂巣琢磨, 川北泉, 丸山理紗, 飯田広範, 杉山敦史, 中西卓也, 逢坂哲彌, 逢坂哲彌

日本磁気学会学術講演概要集 32nd 2008

J-GLOBAL
マグネタイトナノ粒子の粒径および表面修飾が溶液分散性に及ぼす影響

高濱慎太郎, 飯田広範, 高柳浩介, 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集 75th 2008

J-GLOBAL
アルブミン固定化ITO電極のTrp添加にともなう電位応答におけるキラル選択性

上野翼, 松永真理子, 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集 75th 2008

J-GLOBAL
Molecular modification of ITO electrode for chiral discrimination

Ueno Tsubasa, Matsunaga Mariko, Nakanishi Takuya, Osaka Tetsuya

Abstract of annual meeting of the Surface Science of Japan 28th ( 0 ) 29 - 29 2008

DOI CiNii J-GLOBAL
金ナノ粒子を用いた光導波路分光法による生体分子間反応の検出

梶浦真由紀, 中西卓也, 飯田広範, 逢坂哲彌, 逢坂哲彌

応用物理学会学術講演会講演予稿集 69th ( 3 ) 2008

J-GLOBAL
マグネタイトナノ粒子の正常細胞とがん細胞への取り込み評価

高浜慎太郎, ZHANG H., 中西卓也, 逢坂哲彌, 逢坂哲彌

日本磁気学会学術講演概要集 32nd 2008

J-GLOBAL
加水分解反応による酸化鉄ナノ粒子の合成-粒径と磁気特性の制御-

飯田広範, 高柳浩介, 中西卓也, 逢坂哲彌

日本化学会講演予稿集 87th ( 1 ) 2007

J-GLOBAL
FePtナノキューブの熱処理によるL1₀規則化

蜂巣琢磨, 飯田広範, 杉山敦史, 中西卓也, 朝日透, 朝日透, 逢坂哲彌, 逢坂哲彌

次世代磁気記録材料・システムへの挑戦 2007

J-GLOBAL
イオン液体中での鉄-白金ナノ粒子の合成

川北泉, 飯田広範, 杉山敦史, 中西卓也, 逢坂哲彌, 逢坂哲彌, 小原智

次世代磁気記録材料・システムへの挑戦 2007

J-GLOBAL
新規磁気記録媒体用の立方状fcc-FePtナノ粒子の作製

蜂巣琢磨, 杉山敦史, 飯田広範, 中西卓也, 朝日透, 朝日透, 逢坂哲彌, 逢坂哲彌

日本応用磁気学会学術講演概要集 31st 2007

J-GLOBAL
リポソーム封入マグネタイトナノ粒子の作製と磁気特性の評価

高柳浩介, 飯田広範, 高浜慎太郎, 中西卓也, 逢坂哲彌, 逢坂哲彌

電気化学秋季大会講演要旨集 2007 2007

J-GLOBAL
金ナノ粒子固定化光導波路上におけるビオチン-ストレプトアビジン反応の検出

梶浦真由紀, 高田晴美, 飯田広範, 中西卓也, 逢坂哲彌

電気化学会大会講演要旨集 74th 2007

J-GLOBAL
Fabrication of High-B_s CoFe Film by Pulsed Electrodeposition

LIN Bingrong, YOSHIDA Midori, NAKANISHI Takuya, SUGIYAMA Atsushi, OSAKA Tetsuya

IEICE technical report. Magnetic recording 106 ( 335 ) 41 - 42 2006.11

　View Summary

CoFe soft magnetic thin films with high saturation magnetic flux density B_s were prepared by electrodeposition. The B_s value of CoFe alloy films prepared by direct-current electrodeposition is as high as that of bulk alloys with 24kG, however, the coercivity H_c values are higher than 12 Oe. The application of pulsed electrodeposition, especially pulse-reverse electrodeposition, resulted in the decrease of H_c to approximately 1 Oe. It is suggested that decreasing H_c of the films by pulse-reverse electrodeposition is caused by relaxation of film stress and smoothing of surface morphology.

CiNii
Synthesis of magnetic nanoparticles and their application to bioassays

Tetsuya Osaka, Tadashi Matsunaga, Takuya Nakanishi, Atsushi Arakaki, Daisuke Niwa, Hironori Iida

ANALYTICAL AND BIOANALYTICAL CHEMISTRY 384 ( 3 ) 593 - 600 2006.02 [Refereed]

Book review, literature introduction, etc.

　View Summary

Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.

DOI PubMed CiNii
電析CoFe薄膜の磁気特性に及ぼすめっき下地層の影響

LIN Bingrong, 平岩稔久, 中西卓也, 杉山敦史, 逢坂哲彌, 逢坂哲彌, 逢坂哲彌

表面技術協会講演大会講演要旨集 113th 2006

J-GLOBAL
Synthesis of iron oxide nanoparticles by hydrolysis with 1,6-hexanediamine

高柳浩介, 飯田広範, 中西卓也, 逢坂哲彌

日本化学会講演予稿集 86th ( 1 ) 2006

J-GLOBAL
光導波路上への金ナノ粒子の固定化および表面プラズモン吸収特性の評価

高田晴美, 梶浦真由紀, 飯田広範, 中西卓也, 逢坂哲彌

電気化学秋季大会講演要旨集 2006 2006

J-GLOBAL
Development of electrochemical chiral sensing method by using chiral ligand exchange on the Au electrode modified with L-Homocysteine

松永真理子, 巽智香, 中西卓也, 朝日透, 逢坂哲彌

日本化学会講演予稿集 86th ( 1 ) 2006

J-GLOBAL
Formation of nanoparticle composite by interparticle linkage between iron-oxide and gold nanoparticles

飯田広範, 中西卓也, 逢坂哲彌

日本化学会講演予稿集 86th ( 1 ) 2006

J-GLOBAL
ホモシステイン単分子膜修飾金電極におけるカテキンの酸化還元のキラル選択性

長坂誠, 上野翼, 松永真理子, 中西卓也, 朝日透, 逢坂哲彌

電気化学秋季大会講演要旨集 2006 2006

J-GLOBAL
Decrease in H_c of high-B_s CoFe thin films by means of pulsed electrodeposition

HIRAIWA T., SENUMA H., NAKANISHI T., SUGIYAMA A., OSAKA T.

28 5 - 5 2004.09

CiNii
ULSI銅配線用バリア層形成における無電解NiBめっきプロセス

野中佑一, 吉野正洋, 横島時彦, 中西卓也, 逢坂哲彌

エレクトロニクス実装学術講演大会講演論文集 17th (Web) 2003

J-GLOBAL
自己組織化単分子層をシード層へ適用した無電解NiReP拡散防止層の作製と評価

逢坂哲弥, 高野奈央, 黒川哲也, 金子具視, 中西卓也, 上野和良

電気化学会大会講演要旨集 69th 2002

J-GLOBAL
Effect of C content on properties of electrodeposited CoNiFeMoC soft magnetic thin films

KAWASHIMA A., YOKOSHIMA T., NAKANISHI T., OSAKA T., OHASHI K.

25 368 - 368 2001.09

CiNii
Magnetic properties and thermal stability of electrodeposited CoNiFeMoC soft magnetic thin films with high B_s, and highρ

KAWASHIMA A., YOKOSHIMA T., SOGAWA Y., NAKANISHI T., OSAKA T., OHASHI K.

24 300 - 300 2000.09

CiNii
Increasing the resistivity of electrodeposited CoNiFe soft magnetic thin film by addition of amino acids

MIZUTANI S., SHIGA D., YOKOSHIMA T., NAKANISHI T., OSAKA T.

24 301 - 301 2000.09

CiNii
Magnetic properties of electrodepositef high Bs CoNiFe thin film with high resistivity

KASEDA M., YOSHIMITSU Z., YOKOSHIMA T., NAKANISHI T., OSAKA T.

23 473 - 473 1999.10

CiNii
Increasing the resistivity of electrodeposited CoNiFe soft magnetic thin films by Mo addition.

SOGAWA Y., KAWASHIMA A., YOKOSHIMA T., NAKANISHI T., OSAKA T., OHASHI K.

23 472 - 472 1999.10

CiNii
Construction and Characteristic Functions of Thin Layered Film of Semiconductor‐Nanoparticles. Advance in Organic‐Inorganic Composites.

Takuya Nakanishi, Bunsho Ohtani

Shokubai (Catalysts & Catalysis) 40 ( 7 ) 552 - 559 1998.10 [Invited]

CiNii J-GLOBAL
Fabrication and characterization of semiconductor-particle monolayers attached on a self-assembled monolayer of alkanedithiol.

Takuya Nakanishi, Bunsho Ohtani, Kohei Uosaki

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 215 U462 - U462 1998.04

Research paper, summary (international conference)
Construction of semiconductor nanoparticle layers on gold by self-assembly technique.

Bunsho Ohtani, Takuya Nakanishi, Kohei Uosaki

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 214 304 - PHYS 1997.09

Research paper, summary (international conference)

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Industrial Property Rights

電極、燃料電池、およびそれらの製造方法

諸岡哲朗, 中西卓也, 増田卓也

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J-GLOBAL
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FePtナノ粒子の製造方法

逢坂哲彌, 杉山敦史, 川北泉, 中西卓也, 飯田広範, 小島邦彦, 多田健太郎, 小原智, 岩城仁

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Patent

J-GLOBAL
磁気微粒子包含細胞及びその製造方法

特許第5476620号

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J-GLOBAL
光学分割剤、光学分割カラム及び光学分割方法並びに光学活性化合物の製造方法

大谷文章, 逢坂哲彌, 中西卓也, 万木啓嗣

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J-GLOBAL
光学分割剤、光学分割カラム及び光学分割方法並びに光学活性化合物の製造方法

特許第3920149号

大谷文章, 逢坂哲彌, 中西卓也, 万木啓嗣

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