2022/01/25 更新

写真a

マエダ セイジ
前田 清司
所属
スポーツ科学学術院 スポーツ科学部
職名
教授

兼担

  • 附属機関・学校   グローバルエデュケーションセンター

学位

  • 筑波大学   修士(体育学)

  • University of Tsukuba   M.S.

  • 筑波大学   博士(体育科学)

  • University of Tsukuba   Ph.D.

所属学協会

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    日本臨床スポーツ医学会

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    日本体育学会

  •  
     
     

    日本運動生理学会

  •  
     
     

    日本体力医学会

  •  
     
     

    American College of Sports Medicine

 

研究分野

  • スポーツ科学

論文

  • Renal hemodynamics across the adult lifespan: Relevance of flow pulsatility to chronic kidney disease

    Keisei Kosaki, Takashi Tarumi, Jun Sugawara, Koichiro Tanahashi, Hiroshi Kumagai, Masahiro Matsui, Takeshi Sugaya, Yosuke Osuka, Kiyoji Tanaka, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Seiji Maeda

    Experimental Gerontology   152   111459 - 111459  2021年09月

    DOI

  • Central Blood Pressure in Young Kendo Athletes: Implications of Combined Anaerobic and Strength Training

    Masaki Yoshioka, Kaname Tagawa, Yuriko Tochigi, Tomohito Sato, Jiyeon Park, Reiko Momma, Youngju Choi, Jun Sugawara, Seiji Maeda

    ARTERY RESEARCH   27 ( 2 ) 87 - 92  2021年06月

     概要を見る

    Background: Exercise training-induced adaptation of central Blood Pressure (BP) depends on exercise mode. Kendo, a traditional Japanese martial art, is a unique exercise mode because its training encompasses anaerobic and resistance training components. However, the effects of habitual kendo training on central BP have not been established.Objective: The aim of this study was to compare the central BP of high-level kendo athletes and age-matched controls without exercise habits.Methods: Thirty-six young university kendo athletes (the kendo athlete group) and 29 young sedentary individuals (the control group) participated in this cross-sectional study. Central hemodynamics were estimated from carotid arterial waveforms via a generalized transfer function. Stroke volume was computed from brachial arterial waveforms using the Modelflow method.Results: Central systolic BP and Central Pulse Pressure (cPP) were higher in the kendo athlete group than in the control group (both, p < 0.01). Central diastolic BP did not differ between the two groups. Stroke Volume Index (SVI; stroke volume adjusted for body surface area) and the maximum rate of aortic pressure rise during systole (dP/dT(max)), which reflects left ventricle contractility, were significantly higher in the kendo athlete group than in the control group (p < 0.05), and these parameters showed a significant positive correlation with cPP (SVI: r = 0.34, p < 0.01; dP/dT(max): r = 0.79, p < 0.01).Conclusion: These results suggest that habitual kendo training may increase central pulse pressure through increases in left ventricular systolic function.HIGHLIGHTSKendo is ideal for investigating of training adaptation since it induces the characteristics of anaerobic exercise training and resistance training; that is, kendo athletes had both high anaerobic capacity and high muscle strength compared with sedentary controls.In the present study, central blood pressure (central systolic blood pressure and central pulse pressure) was significantly higher in the kendo athlete group than in the control group.Stroke Volume Index (SVI; stroke volume adjusted for body surface area) and the maximum rate of aortic pressure rise during systole (dP/dT(max)) but not augmented pressure in the kendo athlete group were also significantly higher than those in the control group.In addition, SVI and dP/dT(max) showed a significant positive correlation with central pulse pressure.These results suggest that combined anaerobic exercise and muscular strength training may increase central blood pressure through increases in left ventricular systolic function. (C) 2021 The Authors. Publishing services by Atlantis Press International B.V.

    DOI

  • Comparison between volunteer- and expert-led versions of a community-based weight-loss intervention

    Ryoko Mizushima, Yoshio Nakata, Hiroyuki Sasai, Xinyu Zuo, Seiji Maeda, Kiyoji Tanaka

    Preventive Medicine Reports   22   101370 - 101370  2021年06月

    DOI

  • Aerobic Exercise Restores Aging-Associated Reductions in Arterial Adropin Levels and Improves Adropin-Induced Nitric Oxide-Dependent Vasorelaxation.

    Shumpei Fujie, Natsuki Hasegawa, Naoki Horii, Masataka Uchida, Kiyoshi Sanada, Takafumi Hamaoka, Jaume Padilla, Luis A Martinez-Lemus, Seiji Maeda, Motoyuki Iemitsu

    Journal of the American Heart Association   10 ( 10 ) e020641  2021年05月  [国際誌]

     概要を見る

    Background Adropin is a peptide hormone that promotes nitric oxide (NO) production via activation of endothelial NO synthase (eNOS) in endothelial cells. Its circulating levels are reduced with aging and increased with aerobic exercise training (AT). Using a mouse model, we hypothesized that AT restores aging-associated reductions in arterial and circulating adropin and improves adropin-induced NO-dependent vasorelaxation. Further, we hypothesized these findings would be consistent with data obtained in elderly humans. Methods and Results In the animal study, 50-week-old SAMP1 male mice that underwent 12 weeks of voluntary wheel running, or kept sedentary, were studied. A separate cohort of 25-week-old SAMP1 male mice were used as a mature adult sedentary group. In the human study, 14 healthy elderly subjects completed an 8-week AT program consisting of 45 minutes of cycling 3 days/week. In mice, we show that advanced age is associated with a decline in arterial and circulating levels of adropin along with deterioration of endothelial function, arterial NO production, and adropin-induced vasodilation. All these defects were restored by AT. Moreover, AT-induced increases in arterial adropin were correlated with increases in arterial eNOS phosphorylation and NO production. Consistently with these findings in mice, AT in elderly subjects enhanced circulating adropin levels and these effects were correlated with increases in circulating nitrite/nitrate (NOx) and endothelial function. Conclusions Changes in arterial adropin that occur with age or AT relate to alterations in endothelial function and NO production, supporting the notion that adropin should be considered a therapeutic target for vascular aging. Registration URL: https://www.umin.ac.jp; Unique identifier: UMIN000035520.

    DOI PubMed

  • Stature is negatively associated with increased arterial stiffness after high-intensity bicep curls training in young Japanese men

    Kaname Tagawa, Youngju Choi, Song-Gyu Ra, Toru Yoshikawa, Hiroshi Kumagai, Seiji Maeda

    European Journal of Sport Science     1 - 35  2021年03月

    DOI

  • Proximal Aortic Compliance in Young Male Endurance Athletes: An MRI Study.

    Takashi Tarumi, Takayuki Yamabe, Marina Fukuie, Ryota Kimura, David C Zhu, Keigo Ohyama-Byun, Seiji Maeda, Jun Sugawara

    Medicine and science in sports and exercise   53 ( 3 ) 543 - 550  2021年03月  [国際誌]

     概要を見る

    INTRODUCTION: High-intensity endurance training can elicit profound cardiac adaptations; however, the current evidence as to its impact on the proximal aorta is limited. The purpose of this study was to investigate the morphological and functional characteristics of the proximal aorta in endurance athletes. METHODS: Fifteen young male middle- and long-distance runners were compared with 19 age- and sex-matched sedentary control participants. CINE phase-contrast magnetic resonance imaging was used to measure blood flow velocities and cross-sectional areas of the ascending and proximal descending aorta. Aortic blood pressure was measured simultaneously during the phase-contrast magnetic resonance imaging scan using a generalized transfer function. Maximal oxygen uptake (V˙O2max) was measured in the athletes. Left ventricular morphology was assessed in a subgroup of participants (n = 16) with cardiac magnetic resonance imaging. RESULTS: The athlete group exhibited an average V˙O2max of 69.5 ± 3.1 mL·kg-1⋅min-1, which is above the 90th percentile of men with similar age according to the American College of Sports Medicine guideline. The athletes had significantly higher stroke volume and slower heart rate at rest and greater left ventricular end-diastolic volume and mass than the sedentary participants. Significantly larger cross-sectional areas and higher compliance of the ascending and proximal descending aorta were also found in the athletes, independently of body surface area. Moreover, higher compliance of the ascending aorta was associated with greater stroke volume (r = 0.382, P = 0.026) and slower heart rate (r = -0.442, P = 0.009) across all participants. CONCLUSIONS: The proximal aorta of young male endurance athletes undergoes morphological and functional adaptations that may be resulting from the significant hemodynamic alterations associated with their cardiac function.

    DOI PubMed

  • MOTS-c reduces myostatin and muscle atrophy signaling

    Hiroshi Kumagai, Ana Raquel Coelho, Junxiang Wan, Hemal Mehta, Kelvin Yen, Amy Huang, Hirofumi Zempo, Noriyuki Fuku, Seiji Maeda, Paulo J. Oliveira, Pinchas Cohen, Su-Jeong Kim

    American Journal of Physiology-Endocrinology and Metabolism    2021年02月

     概要を見る

    Obesity and type 2 diabetes are metabolic diseases, often associated with sarcopenia and muscle dysfunction. MOTS-c, a mitochondrial-derived peptide, acts as a systemic hormone and has been implicated in metabolic homeostasis. Although MOTS-c improves insulin sensitivity in skeletal muscle, whether MOTS-c impacts muscle atrophy is not known. Myostatin is a negative regulator of skeletal muscle mass and also one of the possible mediators of insulin resistance-induced skeletal muscle wasting. Interestingly, we found that plasma MOTS-c levels are inversely correlated with myostatin levels in human subjects. We further demonstrated that MOTS-c prevents palmitic acid-induced atrophy in differentiated C2C12 myotubes, while MOTS-c administration decreased myostatin levels in plasma in diet-induced obese mice. By elevating AKT phosphorylation, MOTS-c inhibits the activity of an upstream transcription factor for myostatin and other muscle wasting genes, FOXO1. MOTS-c increases mTORC2 and inhibits PTEN activity, which modulates AKT phosphorylation. Further upstream, MOTS-c increases CK2 activity, which leads to PTEN inhibition. These results suggest that through inhibition of myostatin, MOTS-c could be a potential therapy for insulin resistance-induced skeletal muscle atrophy as well as other muscle wasting phenotypes including sarcopenia.

    DOI

  • Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men

    Hiroshi Kumagai, Asako Zempo-Miyaki, Toru Yoshikawa, Kanae Myoenzono, Koichiro Tanahashi, Nobuhiko Akazawa, Seiji Maeda

    JOURNAL OF MENS HEALTH   17 ( 2 ) 64 - 69  2021年

     概要を見る

    Background: Both endothelial dysfunction and low circulating androgen levels predict cardiovascular disease in men. Endothelial function evaluation is commonly performed by measuring flow-mediated vasodilatation of the brachial artery. However, studies have suggested that compared with evaluation of large arteries, microvascular function evaluation of peripheral arteries is a better predictor of increased cardiovascular disease risks. Although circulating levels of androgens, such as testosterone and dehydroepiandrosterone sulfate (DHEA-S), positively correlate with cardiovascular function, the association between circulating androgen levels and microvascular function is unknown. In this study, we investigated whether serum androgen levels correlate with microvascular endothelial function in men.Methods: The study included 105 Japanese men (age 59 +/- 1 years) in whom we measured serum testosterone and DHEA-S levels. The reactive hyperemia index (RHI) determined by the Endo-PAT system (finger plethysmography) was used to evaluate microvascular endothelial function.Results: Serum testosterone levels were significantly correlated with the RHI (r = 0.32, P < 0.01). The association between serum testosterone levels and the RHI remained significant even after adjustment for confounders, including age and body mass index (beta = 0.31, P < 0.01). Notably, serum DHEA-S levels were not associated with the RHI (r = 0.01, n.s.).Conclusion: This study showed that serum testosterone levels were positively correlated with microvascular endothelial function in men. These results suggest that endogenous testosterone level is one of the determinants of microvascular endothelial function and may become a biomarker reflecting lifestyle modifications-induced improvement in cardiovascular function in men.

    DOI

  • Relationship between serum testosterone concentration and microvascular endothelial function in Japanese men

    Hiroshi Kumagai, Asako Zempo-Miyaki, Toru Yoshikawa, Kanae Myoenzono, Koichiro Tanahashi, Nobuhiko Akazawa, Seiji Maeda

    Journal of Men's Health   17 ( 2 ) 64 - 69  2021年

     概要を見る

    Background: Both endothelial dysfunction and low circulating androgen levels predict cardiovascular disease in men. Endothelial function evaluation is commonly performed by measuring flow-mediated vasodilatation of the brachial artery. However, studies have suggested that compared with evaluation of large arteries, microvascular function evaluation of peripheral arteries is a better predictor of increased cardiovascular disease risks. Although circulating levels of androgens, such as testosterone and dehydroepiandrosterone sulfate (DHEA-S), positively correlate with cardiovascular function, the association between circulating androgen levels and microvascular function is unknown. In this study, we investigated whether serum androgen levels correlate with microvascular endothelial function in men. Methods: The study included 105 Japanese men (age 59 ± 1 years) in whom we measured serum testosterone and DHEA-S levels. The reactive hyperemia index (RHI) determined by the Endo-PAT system (finger plethysmography) was used to evaluate microvascular endothelial function. Results: Serum testosterone levels were significantly correlated with the RHI (r = 0.32, P < 0.01). The association between serum testosterone levels and the RHI remained significant even after adjustment for confounders, including age and body mass index (β = 0.31, P < 0.01). Notably, serum DHEA-S levels were not associated with the RHI (r = 0.01, n.s.). Conclusion: This study showed that serum testosterone levels were positively correlated with microvascular endothelial function in men. These results suggest that endogenous testosterone level is one of the determinants of microvascular endothelial function and may become a biomarker reflecting lifestyle modifications-induced improvement in cardiovascular function in men.

    DOI

  • Cerebral blood flow velocity is associated with endothelial function in men

    Nobuhiko Akazawa, Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Koichiro Tanahashi, Seiji Maeda

    Journal of Men's Health   17 ( 3 ) 41 - 46  2021年

     概要を見る

    Background and objective: Reduction in cerebral blood flow with aging leads to cognitive decline and brain atrophy. Cerebrovascular hemodynamics are associated with vascular function. However, little is known about endothelial function in relation to cerebral blood flow at rest. The present study aimed to examine the association between microvascular endothelial function and middle cerebral blood flow. Material and methods: This study involved 60 healthy middle-aged and elderly men. The microvascular endothelial function was measured via digital reactive hyperemia index using pulse amplitude tonometry, and the mean middle cerebral blood flow velocity and cerebrovascular conductance were measured using transcranial Doppler ultrasonography. Results and conclusions: Reactive hyperemia index was significantly correlated with the mean middle cerebral blood flow velocity and cerebrovascular conductance. Multiple regression analysis further indicated that the correlation was significant after adjustment of covariates, such as age, body mass index, smoking status, medication history, blood pressure, and arterial stiffness. Further, Reactive hyperemia index was found to be a significant independent determinant of the mean middle cerebral blood flow velocity and cerebrovascular conductance. The present study demonstrated that vascular endothelial function is associated with cerebral blood flow and is an independent potential confounding factor in healthy middle-aged and older men.

    DOI

  • 女子陸上競技選手における月経前症候群とジャンプパフォーマンスの関係

    門馬 怜子, 棚橋 嵩一郎, 栃木 悠里子, 濱崎 愛, 高橋 あかり, 佐藤 智仁, 横田 伍, 目崎 登, 前田 清司

    体力科学   70 ( 1 ) 101 - 108  2021年

     概要を見る

    <p>Premenstrual syndrome (PMS) that occur during late luteal phase is a problem for many female athletes. Many studies reported that subjective condition is affected by PMS in female athletes. Moreover, female athletes with PMS have higher stress and/or anxiety levels during luteal phase compared with non-PMS athletes. However, the relationship between PMS and physical performance in female athletes are not clarified yet. The purpose of this study was to investigate the relationship between premenstrual syndrome (PMS) and jump performance in female track and field athletes. Sixteen participants who has natural basal body temperature pattern with the menstrual cycle (observed low-temperature and high-temperature phase), were participated in this study. PMS was assessed by ACOG's premenstrual syndrome questionnaire. As physical performance, counter movement jump (CMJ) and rebound jump (RJ) were evaluated in low-temperature phase and high-temperature phase. The result of this study, no significant differences were observed in body composition and physical performance between low-temperature phase and high-temperature phase. However, compared with participants who had non-symptom, participants who had a breast tenderness of PMS showed larger decreases in jump height of CMJ (p = 0.038) and RJ index (p = 0.015) in high-temperature phase. Therefore, PMS may have a negative effect on physical performance during high-temperature phase in female athletes.</p>

    DOI CiNii

  • Different degree of intervention in 6-month weight-loss support and arterial stiffness: Secondary analysis of a randomized controlled trial

    Yoko Tanabe, Yoshio Nakata, Asako Zempo-Miyaki, Mutsuko Y. Hieda, Youngju Choi, Naoto Fujii, Seiji Maeda

    Obesity Research & Clinical Practice   15 ( 1 ) 93 - 95  2021年01月

    DOI

  • The impact of aerobic fitness on arterial stiffness and adrenal cortex hormones in middle-aged and older adults.

    Nobuhiko Akazawa, Koichiro Tanahashi, Keisei Kosaki, Hiroshi Kumagai, Satoshi Oikawa, Ai Hamasaki, Seiji Maeda

    Endocrine journal   67 ( 12 ) 1199 - 1205  2020年12月  [国内誌]

     概要を見る

    An increase in arterial stiffness with advance aging is a risk for cardiovascular disease. Cardiovascular dysfunction is associated with the imbalance of adrenal cortex hormones, especially with the cortisol/dehydroepiandrosterone sulfate (DHEAs) ratio. However, the impact of aerobic fitness on arterial stiffness and cortisol/DHEAs ratio is unclear. The aim of this study was to investigate the relationship between aerobic fitness, arterial stiffness, and cortisol/DHEAs ratio. A total of 198 middle-aged and older adults (aged 50-79 years old) participated in this study. The aerobic fitness evaluated by peak oxygen consumption (VO2peak), carotid-femoral pulse wave velocity (cfPWV) as an indicator of arterial stiffness, and serum cortisol and DHEAs and their ratio were measured. The subjects were divided into the lower (n = 100) and the higher (n = 98) aerobic fitness groups based on the median value of VO2peak. There were no significant differences in serum cortisol and DHEAs concentration alone between the lower and higher fitness groups. However, the cortisol/DEHAs ratio and cfPWV in the higher fitness group was smaller than in the lower fitness group (p < 0.05). The cortisol/DHEAs ratio was significantly correlated with cfPWV (r = 0.159, p < 0.05). These findings suggest that the cortisol/DHEAs ratio is associated with aerobic fitness and arterial stiffness in middle-aged and older adults.

    DOI PubMed

  • Regular aerobic exercise improves sexual function assessed by the Aging Males' Symptoms questionnaire in adult men.

    Hiroshi Kumagai, Kanae Myoenzono, Toru Yoshikawa, Takehiko Tsujimoto, Kosei Shimomura, Seiji Maeda

    The aging male : the official journal of the International Society for the Study of the Aging Male   23 ( 5 ) 1194 - 1201  2020年12月  [国際誌]

     概要を見る

    The leading cause of aging-induced male-specific disorders such as physical, mental and/or sexual symptoms is testosterone deficiency. Although aerobic exercise is suggested to improves circulating testosterone levels, physical fitness, depressive symptoms, and sexual function, the effect of regular aerobic exercise on aging-induced disorders has not yet been clarified. Here we performed cross-sectional and interventional studies to identify the effect of aerobic exercise on aging-induced disorders assessed by the Aging Males' Symptoms questionnaire (AMS). In study 1, the relationship between aerobic exercise capacity (i.e. peak oxygen consumption) and AMS scores were cross-sectionally examined in 169 adult men. In study 2, the effect of a 12-week regular aerobic exercise on AMS scores was longitudinally investigated in 18 adult men. In study 1, the AMS-total, AMS-somatic, AMS-psychological, and AMS-sexual scores were significantly correlated to aerobic exercise capacity even after considering age and testosterone levels. In study 2, 12-week aerobic exercise training significantly improved AMS-sexual and tended to improve AMS-total scores. Additionally, an increase in vigorous physical activity was correlated to improve in the AMS-sexual score. These results suggest that regular aerobic exercise is an effective strategy to improve aging-induced disorders in men.

    DOI PubMed

  • Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults

    Masahiro Matsui, Keisei Kosaki, Koichiro Tanahashi, Nobuhiko Akazawa, Yosuke Osuka, Kiyoji Tanaka, Makoto Kuro-o, Seiji Maeda

    Experimental Gerontology   141  2020年11月

     概要を見る

    © 2020 Elsevier Inc. Objective: Circulating levels of fibroblast growth factor 21 (FGF21) increase with advancing age and may lead to the development of cardiometabolic diseases via impaired lipid and glucose metabolism. While physical activity can reduce these risks of cardiometabolic dysfunction, it remains obscure whether circulation FGF21 levels are influenced by physical activity. The purpose of this study was to investigate the relations between daily physical activities and circulating FGF21 levels in middle-aged and older adults. Methods: In this cross-sectional study with 110 middle-aged and 102 older adults, circulating (serum) FGF21 levels were evaluated by enzyme-linked immunosorbent assay, and the time spent in light-intensity physical activity (LPA) and moderate-to-vigorous-intensity physical activity (MVPA) was assessed using a uniaxial accelerometer. Results: Serum FGF21 levels in the older group (158 pg/mL) were significantly higher than those in the middle-aged group (117 pg/mL). When we examined the joint association of age (middle-aged or older) and MVPA (lower or higher than the median) groups, serum FGF21 levels in the older and higher MVPA group (116 pg/mL) were significantly lower than those in the older and lower MVPA group (176 pg/mL). However, there was no difference in serum FGF21 levels between the lower and higher MVPA groups in the middle-aged group. In multivariable liner regression analysis, serum FGF21 levels were independently determined by MVPA time after adjusting for potential covariates in older adults (β = −0.209). Conclusions: These cross-sectional study findings indicate that the time spent in MVPA is an independent determinant of circulating FGF21 levels, and that an age-related increase in serum FGF21 levels may be attenuated by habitually performing MVPA. (250/250 words).

    DOI PubMed

  • Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults.

    Masahiro Matsui, Keisei Kosaki, Koichiro Tanahashi, Nobuhiko Akazawa, Yosuke Osuka, Kiyoji Tanaka, Makoto Kuro-O, Seiji Maeda

    Experimental gerontology   141   111081 - 111081  2020年11月  [国際誌]

     概要を見る

    OBJECTIVE: Circulating levels of fibroblast growth factor 21 (FGF21) increase with advancing age and may lead to the development of cardiometabolic diseases via impaired lipid and glucose metabolism. While physical activity can reduce these risks of cardiometabolic dysfunction, it remains obscure whether circulation FGF21 levels are influenced by physical activity. The purpose of this study was to investigate the relations between daily physical activities and circulating FGF21 levels in middle-aged and older adults. METHODS: In this cross-sectional study with 110 middle-aged and 102 older adults, circulating (serum) FGF21 levels were evaluated by enzyme-linked immunosorbent assay, and the time spent in light-intensity physical activity (LPA) and moderate-to-vigorous-intensity physical activity (MVPA) was assessed using a uniaxial accelerometer. RESULTS: Serum FGF21 levels in the older group (158 pg/mL) were significantly higher than those in the middle-aged group (117 pg/mL). When we examined the joint association of age (middle-aged or older) and MVPA (lower or higher than the median) groups, serum FGF21 levels in the older and higher MVPA group (116 pg/mL) were significantly lower than those in the older and lower MVPA group (176 pg/mL). However, there was no difference in serum FGF21 levels between the lower and higher MVPA groups in the middle-aged group. In multivariable liner regression analysis, serum FGF21 levels were independently determined by MVPA time after adjusting for potential covariates in older adults (β = -0.209). CONCLUSIONS: These cross-sectional study findings indicate that the time spent in MVPA is an independent determinant of circulating FGF21 levels, and that an age-related increase in serum FGF21 levels may be attenuated by habitually performing MVPA. (250/250 words).

    DOI PubMed

  • High Salt Diet Impacts the Risk of Sarcopenia Associated with Reduction of Skeletal Muscle Performance in the Japanese Population

    Yoshida, Yasuko, Kosaki, Keisei, Sugasawa, Takehito, Matsui, Masahiro, Yoshioka, Masaki, Aoki, Kai, Kuji, Tomoaki, Mizuno, Risuke, Kuro-o, Makoto, Yamagata, Kunihiro, Maeda, Seiji, Takekoshi, Kazuhiro

    NUTRIENTS   12 ( 11 )  2020年11月  [国際誌]

    DOI PubMed

  • Sedentary Behavior, Physical Activity And Bone Mineral Density In Ckd Patients: An Isotemporal Substitution Approach

    Yoshioka, Masaki, Kosaki, Keisei, Matsui, Masahiro, Takahashi, Kanako, Shibata, Ai, Oka, Koichiro, Kuro-o, Makoto, Saito, Chie, Yamagata, Kunihiro, Maeda, Seiji

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   52 ( 17::S ) 455 - 455  2020年07月

  • Sedentary Behavior, Physical Activity, And Baroreflex Sensitivity In Middle-aged And Older Adults

    Mori, Shoya, Kosaki, Keisei, Matsui, Masahiro, Takahashi, Kanako, Yoshioka, Masaki, Tarumi, Takashi, Sugawara, Jun, Shibata, Ai, Oka, Koichiro, Kuro-o, Makoto, Saito, Chie, Yamagata, Kunihiro, Maeda, Seiji

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   52 ( 17::S ) 738 - 738  2020年07月

  • Sedentary behaviour, physical activity, and renal function in older adults: isotemporal substitution modelling.

    Keisei Kosaki, Koichiro Tanahashi, Masahiro Matsui, Nobuhiko Akazawa, Yosuke Osuka, Kiyoji Tanaka, David W Dunstan, Neville Owen, Ai Shibata, Koichiro Oka, Seiji Maeda

    BMC nephrology   21 ( 1 ) 211 - 211  2020年06月  [国際誌]

     概要を見る

    BACKGROUND: Physical inactivity and sedentary behaviour (too much sitting) can contribute to renal dysfunction. However, the potential benefits of behavioural change (e.g. replacing sedentary behaviour with physical activity) on renal function are not well understood. We used isotemporal substitution to model potential impacts of behaviours on renal function by replacing time spent in one behaviour to another. METHODS: In 174 older Japanese adults (age, 50-83 years; females, 76%), the time spent in sedentary behaviour, light-intensity physical activity (LPA), and moderate- to vigorous-intensity physical activity (MVPA) were assessed using an uniaxial accelerometer. Renal function was evaluated by the estimated glomerular filtration rate (eGFR) from serum creatinine and cystatin C levels. RESULTS: In univariate analyses, eGFR was significantly, albeit weakly, correlated with time spent in sedentary behaviour (rs = - 0.229), LPA (rs = 0.265), and MVPA (rs = 0.353). In the isotemporal substitution models, replacement of 30 min/day of sedentary behaviour with an equivalent LPA time was not significantly associated with eGFR (β = 2.26, p = 0.112); however, replacement with an equivalent time of MVPA was beneficially associated with eGFR (β = 5.49, p < 0.05). CONCLUSIONS: These cross-sectional findings suggest that sedentary behaviour (detrimentally) and physical activity (beneficially) may affect renal function and that replacing sedentary behaviour with MVPA may benefit renal health in older adults.

    DOI PubMed

  • Incremental short maximal exercise increases urinary liver‐type fatty acid‐binding protein in adults without CKD

    Keisei Kosaki, Atsuko Kamijo‐Ikemori, Takeshi Sugaya, Shota Kumamoto, Koichiro Tanahashi, Hiroshi Kumagai, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda

    Scandinavian Journal of Medicine & Science in Sports   30 ( 4 ) 709 - 715  2020年04月  [査読有り]

     概要を見る

    Exercise-induced redistribution of tissue blood flow decreases the renal blood flow in an exercise intensity-dependent manner. However, the acute effects of incremental short maximal exercise on renal tubular conditions remain unknown. The purpose of this study was to investigate the acute effects of incremental short maximal exercise on the urinary liver-type fatty acid-binding protein, which is a highly sensitive tubular biomarker that correlates excellently with peritubular capillary blood flow. A total of 116 adults (aged 24-83 years) without chronic kidney disease performed the incremental short maximal exercise using a cycling ergometer, wherein the exercise sequence consisted of commencing with a 2-min workout period at 20 W (as a warm-up period) and then followed by a 10-20 W increase every 1 minute until termination criteria were reached. Urinary samples were gathered before and immediately after the exercise to evaluate the concentrations of urinary creatinine, albumin, and liver-type fatty acid-binding protein. Urinary excretion levels of albumin and liver-type fatty acid-binding protein were significantly increased post-exercise (P P = .008, respectively). Furthermore,

    DOI

  • Increased serum salusin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults.

    Shumpei Fujie, Natsuki Hasegawa, Kiyoshi Sanada, Takafumi Hamaoka, Seiji Maeda, Jaume Padilla, Luis A Martinez-Lemus, Motoyuki Iemitsu

    Aging   12 ( 2 ) 1201 - 1212  2020年01月  [査読有り]  [国際誌]

     概要を見る

    Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increased serum salusin-α is unknown. Herein we assessed carotid-femoral pulse wave velocity (cfPWV), systolic (SBP) and diastolic (DBP) blood pressures in a cross-sectional study that compared young (20-39-year-old, n=45) versus middle-aged and older (40-80-year-old, n=60) subjects. We also performed an interventional study in which 36 young and 40 middle-aged and older subjects underwent eight weeks of aerobic exercise training. In the cross-sectional study, serum salusin-α levels were lesser in middle-aged and older subjects compared to young individuals and negatively correlated with age, SBP, DBP, or cfPWV. In the interventional study, exercise training increased serum salusin-α in middle-aged and older subjects. Notably, negative correlations were noted between the exercise training-induced changes in serum salusin-α and cfPWV, SBP and DBP. Results indicate that advanced age associates with low circulating salusin-α, the levels of which can be augmented by exercise training. Importantly, increased serum salusin-α with exercise correlates with improvements in arterial stiffness and a reduction in blood pressure.

    DOI PubMed

  • Association between Mental Health and Arterial Stiffness in Middle-aged and Older Adults

    Nobuhiko Akazawa, Koichiro Tanahashi, Keisei Kosaki, Ai Hamasaki, Seiji Maeda

    Artery Research   26 ( 4 ) 223 - 223  2020年

    DOI

  • Sleep Quality is associated with Central Arterial Stiffness in Postmenopausal 3 Women: A Cross-sectional Pilot Study

    Youngju Choi, Nobuhiko Akazawa, Asako Zempo-Miyaki, Song-Gyu Ra, Seiji Maeda

    Artery Research    2020年

    DOI

  • The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

    Ai Shindo-Hamasaki, Nobuhiko Akazawa, Reiko Momma, Seiji Maeda

    Artery Research    2020年

    DOI

  • Association between duration of excessive weight and arterial stiffness in middle-aged and older adults

    Masahiro Matsui, Toru Yoshikawa, Ryoko Mizushima, Koichiro Tanahashi, Kanae Myoenzono, Kiyoji Tanaka, Seiji Maeda

    Clinical and Experimental Hypertension   42 ( 3 ) 213 - 217  2020年  [査読有り]  [国際誌]

    DOI PubMed

  • Effects of aerobic exercise training on the arterial stiffness and intramyocellular or extramyocellular lipid in overweight and obese men

    Park J, Choi Y, Myoenzono K, Yoshikawa T, Tagawa K, Isobe T, Saotome K, Sankai Y, Shimojo N, Maeda S

    Clinical and Experimental Hypertension   42 ( 4 ) 302 - 308  2020年  [査読有り]  [国際誌]

    DOI PubMed

  • Beta-hydroxy-beta-methylbutyrateの摂取と筋力運動の併用が閉経後女性の骨格筋量および筋力に及ぼす効果に関する予備的研究:ランダム化クロスオーバー試験

    若葉, 京良, 大須賀, 洋祐, 宮内, 大治, 竹越, 一博, 前田, 清司, 田中, 喜代次

    運動疫学研究   22 ( 1 ) 22 - 34  2020年  [査読有り]

     概要を見る

    <p>目的:本研究の目的は,beta-hydroxy-beta-methylbutyrate(HMB)摂取と筋力運動の併用が閉経後女性の骨格筋量および筋力に及ぼす影響を検討することとした。研究デザインは,オープン化・クロスオーバー・ランダム化比較試験とし,研究期間は52週間(20週間のウォッシュアウト期間を含む)とした。</p><p>方法:閉経後女性57名(60.2±6.0歳)をランダムに2 群(immediate intervention(II)群:29人,delayed intervention(DI)群:28人)に分けた。II群は最初の12週間にHMBと筋力運動による介入プログラムを提供した。その間,DI群は介入を行わず,最後の12週間にII群と同様の介入プログラムを提供した。なお,II群への介入終了後,20週間のウォッシュアウト期間を設けた。主要評価項目は四肢筋量,副次評価項目は最大筋力とした。</p><p>結果:対照条件と比べて,介入条件の四肢筋量の変化値に有意な差はみられなかったが(介入条件 +0.2±0.8 kg,対照条件+0.3±0.8 kg,P = 0.88),最大筋力の変化

    DOI

  • Effect of regular aerobic exercise on plasma 3-hydroxyisobutyrate concentration in overweight and obese men

    Kanae Myoenzono, Toru Yoshikawa, Jiyeon Park, Teruo Miyazaki, Akira Honda, Nobutake Shimojo, Seiji Maeda

    Advance in Exercise and Sport Physiology   25   73 - 79  2020年  [査読有り]

  • Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats

    Jun Tanabe, Yuji Ogura, Keisei Kosaki, Yoshio Nagai, Takeshi Sugaya, Keiichi Ohata, Shiika Watanabe, Daisuke Ichikawa, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Seiji Maeda, Yugo Shibagaki, Atsuko Kamijo-Ikemori

    Journal of Diabetes Research   2020   7614035  2020年  [査読有り]

     概要を見る

    © 2020 Jun Tanabe et al. Background. Type 2 diabetes (T2D) is a known risk factor for diabetic kidney disease (DKD) and sarcopenia in older patients. Because there may be an interaction between DKD and sarcopenia, the aim of the present study is to investigate the relationship between urinary levels of liver-type fatty acid-binding protein (L-FABP) and sarcopenia using a novel rat model of T2D. Methods. Male spontaneously diabetic Torii (SDT) fatty rats (n=5) at 16 weeks of age were used as an animal model of T2D. Age- and sex-matched Sprague-Dawley (SD) rats (n=7) were used as controls. Urine samples were obtained from the rats, and muscle strength was evaluated with the use of the forelimb grip test at 16, 20, and 24 weeks of age. Serum, kidney, soleus, and extensor digitorum longus (EDL) muscle samples were collected at 24 weeks of age. Urinary L-FABP levels were measured using dedicated enzyme-linked immunosorbent assays. Results. Increased urinary L-FABP levels, focal glomerular sclerosis, moderate interstitial inflammation and fibrosis, and accumulation of renal oxidative proteins were significantly observed in the SDT fatty rats, compared to the SD rats. Muscle weight, muscle strength, cross-sectional areas of both type I and type IIb muscle fibers, and increasing rate of muscle strength were significantly decreased in the SDT fatty rats compared to the SD rats at 24 weeks. Urinary L-FABP levels at 20 and 24 weeks were significantly negatively correlated with muscle strength. Urinary L-FABP levels at 16 weeks were significantly negatively correlated with the increasing rate of muscle strength. Conclusions. Urinary L-FABP reflects the degree of muscle strength and weight, as well as cross-sectional areas of muscle fibers. Although further clinical study is needed, urinary L-FABP may be useful to monitor the progression of sarcopenia and DKD in T2D patients.

    DOI PubMed

  • Deterioration of sexual function is associated with central hemodynamics in adult Japanese men

    Hiroshi Kumagai, Toru Yoshikawa, Keisei Kosaki, Kanae Myoenzono, Seiji Maeda

    Hypertension Research   43 ( 1 ) 36 - 44  2020年01月  [査読有り]

    DOI

  • Exercise training reverses aging-associated arterial stiffening and low serum salusin-α levels

    Fujie S, Hasegawa N, Sanada K, Hamaoka T, Maeda S, Padilla J, Martinez-Lemus LA, Iemitsu M

    Aging   12   1201 - 1212  2020年  [査読有り]

  • Changes in plasma amino acid concetrations in overweight and obese men after weight loss program including dietary modification and aerobic exercise (in press)

    Kanae Myoenzono, Toru Yoshikawa, Hiroshi Kumagai, Zempo-Miyaki Asako, Rina So, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    J Phys Fitness Sports Med    2020年  [査読有り]

  • Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation.

    Toshihiro Nakano, Kazuhiro Shiizaki, Yutaka Miura, Masahiro Matsui, Keisei Kosaki, Shoya Mori, Kunihiro Yamagata, Seiji Maeda, Takuya Kishi, Naoki Usui, Masahide Yoshida, Tatsushi Onaka, Hiroaki Mizukami, Ruri Kaneda, Kazunori Karasawa, Kosaku Nitta, Hiroshi Kurosu, Makoto Kuro-O

    Scientific reports   9 ( 1 ) 19247 - 19247  2019年12月  [査読有り]  [国際誌]

     概要を見る

    Circulating levels of fibroblast growth factor-21 (FGF21) start increasing in patients with chronic kidney disease (CKD) since early stages during the cause of disease progression. FGF21 is a liver-derived hormone that induces responses to stress through acting on hypothalamus to activate the sympathetic nervous system and the hypothalamus-pituitary-adrenal endocrine axis. However, roles that FGF21 plays in pathophysiology of CKD remains elusive. Here we show in mice that FGF21 is required to survive CKD but responsible for blood pressure dysregulation. When introduced with CKD, Fgf21-/- mice died earlier than wild-type mice. Paradoxically, these Fgf21-/- CKD mice escaped several complications observed in wild-type mice, including augmentation of blood pressure elevating response and activation of the sympathetic nervous system during physical activity and increase in serum noradrenalin and corticosterone levels. Supplementation of FGF21 by administration of an FGF21-expressing adeno-associated virus vector recapitulated these complications in wild-type mice and restored the survival period in Fgf21-/- CKD mice. In CKD patients, high serum FGF21 levels are independently associated with decreased baroreceptor sensitivity. Thus, increased FGF21 in CKD can be viewed as a survival response at the sacrifice of blood pressure homeostasis.

    DOI PubMed

  • Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation.

    Toshihiro Nakano, Kazuhiro Shiizaki, Yutaka Miura, Masahiro Matsui, Keisei Kosaki, Shoya Mori, Kunihiro Yamagata, Seiji Maeda, Takuya Kishi, Naoki Usui, Masahide Yoshida, Tatsushi Onaka, Hiroaki Mizukami, Ruri Kaneda, Kazunori Karasawa, Kosaku Nitta, Hiroshi Kurosu, Makoto Kuro-O

    Scientific reports   9 ( 1 ) 19247 - 19247  2019年12月  [査読有り]  [国際誌]

     概要を見る

    Circulating levels of fibroblast growth factor-21 (FGF21) start increasing in patients with chronic kidney disease (CKD) since early stages during the cause of disease progression. FGF21 is a liver-derived hormone that induces responses to stress through acting on hypothalamus to activate the sympathetic nervous system and the hypothalamus-pituitary-adrenal endocrine axis. However, roles that FGF21 plays in pathophysiology of CKD remains elusive. Here we show in mice that FGF21 is required to survive CKD but responsible for blood pressure dysregulation. When introduced with CKD, Fgf21-/- mice died earlier than wild-type mice. Paradoxically, these Fgf21-/- CKD mice escaped several complications observed in wild-type mice, including augmentation of blood pressure elevating response and activation of the sympathetic nervous system during physical activity and increase in serum noradrenalin and corticosterone levels. Supplementation of FGF21 by administration of an FGF21-expressing adeno-associated virus vector recapitulated these complications in wild-type mice and restored the survival period in Fgf21-/- CKD mice. In CKD patients, high serum FGF21 levels are independently associated with decreased baroreceptor sensitivity. Thus, increased FGF21 in CKD can be viewed as a survival response at the sacrifice of blood pressure homeostasis.

    DOI PubMed

  • タモキシフェン誘導性Dicer欠損マウスにおける持久運動誘発性の筋適応(Endurance exercise-induced muscle adaptation in tamoxifen-inducible Dicer knockout mice)

    Oikawa Satoshi, Lee Minjung, Motohashi Norio, Maeda Seiji, Akimoto Takayuki

    The Journal of Physical Fitness and Sports Medicine   8 ( 6 ) 279 - 279  2019年11月

  • The Relationship Between Changes in Stride Length and Stride Rate, Muscle Damage and Decreases in Pace in the Final stage of a Marathon(和訳中)

    Ishikura Keisuke, Tokinoya Katsuyuki, Yoshida Yasuko, Sekine Nanami, Kosaki Keisei, Kumamoto Shota, Maeda Seiji, Nabekura Yoshiharu, Takekoshi Kazuhiro

    The Journal of Physical Fitness and Sports Medicine   8 ( 6 ) 369 - 369  2019年11月  [査読有り]

  • Effects of Vibrotactile Feedback on Sedentary Behaviors in Adults: A Pilot Randomized Controlled Trial

    Nishimura, Makoto, Sasai, Hiroyuki, Nakata, Yoshio, Maeda, Seiji

    International journal of environmental research and public health   16 ( 23 )  2019年11月

     概要を見る

    No effective and easily implemented intervention strategies for reducing sedentary behavior have been established. This pilot trial (UMIN000024372) investigated whether vibrotactile feedback reduces sedentary behavior. Twenty-six adults aged 30-69 years who were sedentary ≥8 h/day were randomly assigned to control ( = 13) or vibration ( = 13) groups. Participants wore a monitor 9 h daily for seven-day periods at baseline (week zero), during the intervention (weeks one, three, five, and seven), and after the intervention (week eight). During the eight-week intervention, vibration-group participants were notified by a vibration through the monitor whenever continuous sedentary time reached ≥30 min; they also received weekly reports of their sedentary patterns. Control-group participants did not receive feedback. The primary outcome was change in total sedentary time. Changes in longer bouts of sedentary time (≥35 min) were also assessed. No significant difference was found in the change in total sedentary time (control: -17.5 min/9 h, vibration: -9.1 min/9 h; = 0.42). Although no significant differences were observed in sedentary time in longer bouts, vibration-group participa

    DOI

  • Effect of sleep efficiency on salivary metabolite profile and cognitive function during exercise in volleyball athletes

    Nobuhiko Akazawa, Naoko Kobayashi, Yuki Nakamura, Hiroshi Kumagai, Youngju Choi, Seiji Maeda

    European Journal of Applied Physiology   119 ( 10 ) 2215 - 2223  2019年10月  [査読有り]

    DOI

  • Renoprotective effects of voluntary running exercise training on aldosterone-induced renal injury in human L-FABP chromosomal transgenic mice.

    Keisei Kosaki, Takeshi Sugaya, Keiichi Ohata, Jun Tanabe, Seiko Hoshino, Kazuho Inoue, Kenjiro Kimura, Seiji Maeda, Yugo Shibagaki, Atsuko Kamijo-Ikemori

    Hypertension research : official journal of the Japanese Society of Hypertension   42 ( 10 ) 1518 - 1527  2019年10月  [査読有り]  [国際誌]

     概要を見る

    Tubulointerstitial damage is a crucial therapeutic target in preventing chronic kidney disease (CKD) progression. Inappropriately activated renin-angiotensin-aldosterone system (RAAS) in the tubulointerstitial area is strongly associated with tubulointerstitial damage progression. Therefore, this study aimed to determine whether there is a beneficial effect of voluntary running exercise training on aldosterone-induced renal injury. Human L-type fatty acid-binding protein (L-FABP) chromosomal transgenic (L-FABP+/-) male mice were used to evaluate the effect of exercise by using urinary L-FABP, a tubular marker. The mice were assigned to either the exercise group that performed voluntary running exercise training using a running wheel or the control group. Subsequently, two groups were injected with aldosterone (0.125 μg kg-1 min-1) and administered 1% NaCl water, and two groups were administered aldosterone only in solvent 4 weeks after initiating the exercise. Aldosterone was injected for another 4 weeks, and NaCl water was administered from 5 weeks after starting the exercise until 8 weeks. Although both aldosterone and NaCl water significantly decreased the running distance, tubulointerstitial damage involving interstitial infiltration of macrophages and fibrosis and the elevation of urinary human L-FABP induced by aldosterone injection was prevented by voluntary running exercise training. Urinary human L-FABP levels were significantly correlated with the degree of tubulointerstitial damage. In conclusion, voluntary running exercise training delayed tubulointerstitial damage progression in the aldosterone-induced renal injury model and therefore may be a promising nonpharmacological strategy in CKD.

    DOI PubMed

  • Effects of aerobic exercise training on the arterial stiffness and intramyocellular or extramyocellular lipid in overweight and obese men

    Park, Jiyeon, Choi, Youngju, Myoenzono, Kanae, Yoshikawa, Toru, Tagawa, Kaname, Isobe, Tomonori, Saotome, Kousaku, Sankai, Yoshiyuki, Shimojo, Nobutake, Maeda, Seiji

    Clinical and experimental hypertension (New York, N.Y. : 1993)   Epub ( 4 ) 1 - 7  2019年08月  [国際誌]

     概要を見る

    Intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) of ectopic fat in muscles are associated with arterial stiffness in normal-weight individuals. Furthermore, aerobic exercise training-induced changes in IMCL or EMCL content are related to a decrease in arterial stiffness in elderly people. Though arterial stiffness is strongly related with obesity, but the effects of aerobic exercise training on IMCL or EMCL content, with a particular focus on arterial stiffness, in obese individuals remains unclear. Here, we investigated the effects of aerobic exercise training on IMCL or EMCL content and arterial stiffness in obese individuals. First, in a cross-sectional study, we examined the relationship between arterial stiffness and IMCL or EMCL content in 24 overweight and obese men. Secondly, we investigated the effects of aerobic exercise intervention on arterial stiffness and IMCL or EMCL content in 21 overweight and obese men. In the cross-sectional study, EMCL content was positively correlated with baPWV and β-stiffness index, whereas IMCL content was negatively correlated with baPWV. In the intervention study, there were no significant changes in baPWV, β-stiffness ind

    DOI PubMed

  • Role of High Physical Fitness in Deterioration of Male Sexual Function in Japanese Adult Men

    Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Keisei Kosaki, Nobuhiko Akazawa, Koichiro Tanahashi, Kaname Tagawa, Asako Zempo-Miyaki, Seiji Maeda

    American Journal of Men's Health   13 ( 3 ) 155798831984917 - 155798831984917  2019年05月

    DOI

  • Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men

    Tanabe, Yoko, Chino, Kentaro, Sagayama, Hiroyuki, Lee, Hyun Jin, Ozawa, Hitomi, Maeda, Seiji, Takahashi, Hideyuki

    Journal of nutritional science and vitaminology   65 ( 1 ) 82 - 89  2019年04月

     概要を見る

    Curcumin is known to have potent anti-inflammatory effects. We have reported that acute curcumin ingestion attenuates eccentric exercise-induced muscle damage. This study aimed to examine the effect of curcumin ingestion timing (before or after exercise) on the changes in muscle damage markers after eccentric exercise. In this randomized, single-blind, parallel design study, 24 healthy young men performed 30 maximal isokinetic (120º/s) eccentric contractions of the elbow flexors using an isokinetic dynamometer. Subjects were randomly assigned to ingest 180 mg/d of oral curcumin either 7 d before (PRE) or 4 d after exercise (POST) or 180 mg/d of oral placebo 4 d after exercise (CON). The maximal voluntary contraction (MVC) torque of the elbow flexors, elbow joint range of motion (ROM), muscle soreness, and serum creatine kinase (CK) activity were measured before, immediately after, and 1-4 d after exercise. Changes in these variables were compared over time. In the POST group, ROM were higher at 3-4 d and muscle soreness was lower at 3 d after exercise compared with the CON group (p<0.05). However, in the PRE group, there were no significant differences compared with the CON group

    DOI

  • Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation

    Yoko Tanabe, Kentaro Chino, Takahiro Ohnishi, Hitomi Ozawa, Hiroyuki Sagayama, Seiji Maeda, Hideyuki Takahashi

    Scandinavian Journal of Medicine & Science in Sports   29 ( 4 ) 524 - 534  2019年04月  [査読有り]

    DOI

  • 質的分析により抽出した課題を考慮した住民主導による減量支援プログラムの成果検証

    水島 諒子, 笹井 浩行, 中田, 由夫, 前田 清司, 田中喜代次

    健康支援   21 ( 1 ) 29 - 37  2019年02月  [査読有り]

  • Pentraxin 3 increases in adult overweight and obese men after weight loss by dietary modification with exercise training

    Asako Zempo-Miyaki, Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Rina So, Takeshi Otsuki, Kiyoji Tanaka, Seiji Maeda

    Applied Physiology, Nutrition, and Metabolism   44 ( 2 ) 111 - 117  2019年02月  [査読有り]

     概要を見る

    The circulatory level of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, has been shown to be lower in obese individuals than in those with normal weight. However, reports on the effects of different weight-loss methods on PTX3 are limited. The present study aimed to investigate the effect of weight loss on circulating PTX3 levels in overweight and obese men and to examine the combined effect of dietary modification and exercise training on PTX3 levels. Forty-eight overweight and obese men were assigned to 2 groups: dietary modification (group D) or exercise training and dietary modification (group DE). Groups D and DE were composed of 27 and 21 participants, respectively. We observed a significant independent relationship between changes in PTX3 and body mass index (BMI) in all participants (β = −0.617, p &lt; 0.01). Subsequently, we compared the effects of the 2 weight-loss methods on plasma PTX3 in groups D and DE. The magnitude of the increase in plasma PTX3 levels was similar in the 2 groups. Interestingly, we observed that PTX3 levels in group DE increased significantly more than those in group D in subjects who achieved normal weight, based on BMI, after interventions. Our study suggested that weight reduction after lifestyle modification significantly increased PTX3 levels in overweight and obese men, and the addition of habitual exercise to dietary modification enhanced the magnitude of the increase in PTX3 levels in obese individuals achieving normal weight after weight loss.

    DOI

  • Author Correction: Effect of bright-light exposure before sleep on human urine metabolome [J Phys Fitness Sports Med, 8 (2): 89-96 (2019)]

    Nakamura Yuki, Choi Youngju, Akazawa Nobuhiko, Park Insung, Kawana Fusae, Satoh Makoto, Tokuyama Kumpei, Maeda Seiji

    The Journal of Physical Fitness and Sports Medicine   8 ( 3 ) 143 - 143  2019年

     概要を見る

    Reference is lacking in Table 1 and Fig. 2. <br>In addition, Reference 37 should be added in the list.

    DOI CiNii

  • Effect of sleep efficiency on salivary metabolite profile and congnitive function during exercise in volleyball athletes

    Nobuhiko Akazawa, Naoko Kobayashi, Yuki Nakamura, Hiroshi Kumagai, Youngju Choi, Seiji Maeda

    European Journal of Applied Physiology   119 ( 10 ) 2215 - 2223  2019年  [査読有り]

     概要を見る

    [PURPOSE] Sleep duration is known to affect physiological and circadian metabolites and human homeostasis. However, little is known about the relationship between sleep quality and metabolite and cognitive function during exercise. Therefore, the aim of the present study was to investigate the impact of sleep quality on metabolite level and cognitive function in female volleyball athletes.
    [METHODS] Twelve female volleyball athletes participated in this study. Sleep efficiency was measured for 1 week using NemuriSCAN (Paramount Bed Co. Ltd., Japan) as an index of sleep quality. The subjects were divided into better (n = 6) and lesser (n = 6) sleep quality groups by the median value of sleep efficiency. Saliva samples were collected using a Salimetric oral swab cotton and salivary metabolites were analysed using capillary electrophoresis and time-of-flight mass spectrometry. The subjects performed Stroop tasks (simple and difficult tasks) at rest and during aerobic exercise in recumbent cycle ergometer at light and heavy intensity.
    [RESULTS] Increased sleep efficiency was found in the better sleep quality group, whereas total sleep time was similar. There were differences in

    DOI

  • Effect of curcumin ingestion before or after eccentric exercise on changes in skeletal muscle damage and inframmatory makers in humans

    Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H

    Scandinavian Journal of Medicine & Science in Sports   29   524 - 534  2019年  [査読有り]

  • 中・高年齢者の動脈硬化予防としての習慣的運動

    前田, 清司

    医学のあゆみ   269   170 - 174  2019年

  • Effects of aerobic exercise alone on lipids in healthy East Asians: A systematic review and meta-analysis

    Yutaka Igarashi, Nobuhiko Akazawa, Seiji Maeda

    Journal of Atherosclerosis and Thrombosis   26   488 - 503  2019年  [査読有り]

  • Aortic diastolic pressure decay modulates the relation between worsened aortic stiffness and myocardial oxygen supply/demand balance after resistance exercise

    Kaname Tagawa, Akari Takahashi, Atsumu Yokota, Tomohito Sato, Seiji Maeda

    Journal of Applied Physiology127   127   737 - 744  2019年  [査読有り]

  • Association between circulating fibroblast growth factor 21, aerobic fitness, and aortic blood pressure in middle-aged and older women

    Masahiro Matsui, Keisei Kosaki, Nobuhiko Akazawa, Kanako Takahashi, Makoto Kuro-o, Seiji Maeda

    Journal of Physical Fitness and Sports Medicine   8   195 - 201  2019年  [査読有り]

  • Curcumin supplementation attenuates a decrease in endothelial function following eccentric exercise

    Youngju Choi, Yoko Tanabe, Nobuhiko Akazawa, Asako Zempo-Miyaki, Seiji Maeda

    Journal of Exercise Nutrition & Biochemistry   23   7 - 12  2019年  [査読有り]

  • Dietary modification reduces serum ANGPTL2 levels and arterial stiffness in overweight and obese men

    Park J, Choi Y, Mizushima R, Yoshikawa T, Myoenzono K, Tagawa K, Matsui M, Tanaka K, Maeda S

    Journal of Exercise Nutrition and Biochemistry   23   39 - 44  2019年  [査読有り]

  • Effects of taurine supplementation on vascular endothelial function at rest and after resistance exercise

    Song-Gyu Ra, Youngju Choi, Nobuhiko Akazawa, Kentaro Kawanaka, Hajime Ohmori, Seiji Maeda

    Advances in Experimental Medicine and Biology   1155   407 - 414  2019年  [査読有り]  [国際誌]

    DOI PubMed

  • Effect of resistance training combined with aerobic exercise on aortic arterial stiffness in older adults: a secondary analysis of randomized trial

    Keisei Kosaki, Yosuke Osuka, Kiyoji Tanaka, Seiji Maeda

    Journal of Physical Fitness and Sports Medicine   8   203 - 208  2019年  [査読有り]

  • 年齢別100位以内を維持する中高年男性マラソンランナーの加齢に伴うパフォーマンス変化に関する検討

    中沢孝, 辻本健彦, 前田清司, 田中喜代次

    運動疫学研究   21   20 - 27  2019年  [査読有り]

  • アスリートにおける競技特性と動脈スティフネス適応の関連

    吉岡, 将輝, 崔, 英珠, 棚橋, 嵩一郎, 栃木, 悠里子, 佐藤, 智仁, 朴, ジヨン, 門馬, 怜子, 前田, 清司

    体力科学   68 ( 6 ) 381 - 387  2019年  [査読有り]

     概要を見る

    <p></p><p>Arterial stiffness in endurance athletes is low, whereas arterial stiffness in strength athletes is high. The adaptation of the arterial stiffness may be different depending on the training type. On the other hand, there are mixed-trained athletes that can't be classified as endurance- or strength- trained athletes. The aim of this study was to investigate the arterial stiffness among mixed-trained athletes. The total of 51 young male athletes (15 long-distance runners, 10 handball players and 26 kendo players) and 16 young healthy sedentary individuals (control group) participated in this study. Carotid-femoral pulse wave velocity (cfPWV), carotid-brachial PWV (cbPWV) and femoral-ankle PWV (faPWV), were measured as indices of central and peripheral (upper and lower limbs) arterial stiffness, respectively. cfPWV showed significantly lower in long-distance runners (high endurance capacity) and handball players (strength and high endurance capacities) compared with kendo players (strength and low endurance capacities) and control groups (P < 0.05 for both). cbPWV showed significantly lower in handball players and kendo players compared with the control group (<i>P</i

    DOI J-GLOBAL

  • Combined effects of lactotripeptide and aerobic exercise on cognitive function and cerebral oxygenation in middle-aged and older adults

    Hamasaki, Ai, Akazawa, Nobuhiko, Yoshikawa, Toru, Myoenzono, Kanae, Tanahashi, Koichiro, Sawano, Yuriko, Nakata, Yoshio, Maeda, Seiji

    The American journal of clinical nutrition   109 ( 2 ) 353 - 360  2019年01月  [査読有り]  [国際誌]

     概要を見る

    [Background] Age-related declines in cognitive function and cerebral perfusion increase the risk of dementia. Although nutrition and exercise may be effective in reducing cognitive decline, the effect of lactotripeptide (LTP) on cerebral oxygenation and hemodynamics remains unclear.
    [Objectives] The aim of this study was to investigate the effects of LTP ingestion on cerebral oxygenation, cognitive function, and vascular function in middle-aged and older adults with or without an exercise intervention.
    [Methods] We recruited 2 separate groups of participants, one with and one without an exercise intervention. Each group was then randomly assigned into a placebo group and an LTP group. The participants ingested a placebo or LTP every day. The exercise group performed aerobic exercises 4-6 d/wk. Before and after the 8-wk intervention, we measured oxygenated hemoglobin (oxy-Hb) concentration (oxy-Hb change) in the prefrontal cortex during the Stroop task (primary outcome), Stroop interference time, and carotid artery β-stiffness (both secondary outcomes).
    [Results] Sixty-four participants completed the study. Changes in oxy-Hb signal in the prefrontal cortex were greater in the LTP g

    DOI PubMed

  • 慢性腎臓病の重症化予防に向けた運動の役割

    小﨑,恵生, 斎藤,知栄, 山縣,邦弘, 前田,清司

    体力科学   68 ( 1 ) 97 - 98  2019年

    DOI

  • 慢性腎臓病の重症化予防に向けた運動の役割

    小﨑恵生, 斎藤知栄, 山縣邦弘, 前田清司

    体力科学    2019年  [査読有り]

  • 質的分析により抽出した課題を考慮した住民主導による減量支援プログラムの成果検証

    水島諒子, 笹井浩行, 中田由夫, 前田清司, 田中喜代次

    健康支援    2019年  [査読有り]

  • Aerobic exercise training normalizes central blood pressure regulation after oral glucose loading in overweight/obese men

    Yoshikawa T, Kumagai H, Myoenzono K, Tsujimoto T, Tanaka K, Maeda S

    Clin Exper Hypertens   41 ( 1 ) 28 - 35  2019年  [査読有り]  [国際誌]

    DOI PubMed

  • Effective timing of curcumin ingestion to attenuate eccentric exercise-induced muscle soreness in men

    Tanabe Y, Chino K, Sagayama H, Lee HJ, Ozawa H, Maeda S, Takahashi H

    J Nutr Sci Vitaminol    2019年  [査読有り]

  • An inducible knockout of Dicer in adult mice does not affect endurance exercise-induced muscle adaptation

    Oikawa S, Lee M, Motohashi N, Maeda S, Akimoto T

    Am J Physiol Cell Physiol    2019年  [査読有り]

  • Combined effects of lactotoripeptide and aerobic on cognitive function and cerebral oxygenation in middle-aged and older adults

    Hamasaki A, Akazawa N, Yoshikawa T, Myoenzono K, Tanahashi K, Sawano Y, Nakata Y, Maeda S

    Am J Clin Nutr    2019年  [査読有り]

  • The effect of sleep quality on cognitive functions in young healthy men

    Nakamura Y, Choi Y, Akazawa N, Park I, Kawana F, Satoh M, Tokuyama K, Maeda S

    Adv Exerc Sport Physiol    2019年  [査読有り]

  • Effect of bright-light exposure before sleep on the human urine metabolome

    Nakamura, Yuki, Choi, Youngju, Akazawa, Nobuhiko, Park, Insung, Kawana, Fusae, Satoh, Makoto, Tokuyama, Kumpei, Maeda, Seiji

    The Journal of Physical Fitness and Sports Medicine   8 ( 2 ) 89 - 96  2019年  [査読有り]

     概要を見る

    <p>The aim of this study was to investigate the effects of bright-light exposure immediately prior to sleep on the human urine metabolome. Eight young and healthy men were exposed to dim light (control condition) or bright-light (10000 lux) 3 hours before sleep (Bright-light condition: BL). Objective sleep quality was recorded by polysomnography, and subjective sleep quality was evaluated by the Oguri-Shirakawa-Azumi sleep inventory MA version (OSA-MA). Urine samples were collected after waking up under both the BL and control conditions. Polysomnographic analysis showed that sleep latency was significantly increased in BL compared to the control condition. OSA-MA score of refreshing was significantly lower in BL. Moreover, body temperature was significantly higher at times around sleep onset in BL (23:30, 0:00, and 0:30). Together, these results suggest that exposure to bright-light prior to sleep can alter sleep and circadian rhythms. According to analysis of the urine metabolome, the level of Allothreonine was significantly higher and the levels of N-acetylleucine, ornithine, 5-hydroxylysine, carnosine, and 4-amino-3-hydroxybutyric acid were significantly lower in BL (P < 0.05).

    DOI CiNii

  • Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation

    Tanabe, Yoko, Chino, Kentaro, Ohnishi, Takahiro, Ozawa, Hitomi, Sagayama, Hiroyuki, Maeda, Seiji, Takahashi, Hideyuki

    Scandinavian journal of medicine & science in sports   29 ( 4 ) 524 - 534  2018年12月  [査読有り]

     概要を見る

    We examined the effect of curcumin (CUR) ingestion before or after exercise on changes in muscle damage and inflammatory responses after exercise. We conducted two parallel experiments with different CUR ingestion timings using a double-blind crossover. In Exp. 1, ten healthy men ingested 180 mg d of CUR or placebo (PLA) 7 days before exercise. In Exp. 2, ten other healthy men ingested 180 mg d of CUR or PLA 7 days after exercise. They performed 30 maximal isokinetic (120°s ) eccentric contractions of the elbow flexors using an isokinetic dynamometer, and this was repeated with the other arm ≥4 weeks later. Maximal voluntary contraction (MVC) torque of the elbow flexors, elbow joint range of motion (ROM), muscle soreness, and serum creatine kinase (CK) activity were measured before, immediately after, and 1-7 days after exercise. Plasma interleukin-8 (IL-8) was measured before, immediately after, 12 hours after, and 1-7 days after exercise. The changes were compared over time. In Exp. 1, no significant differences were found between CUR and PLA subjects for each parameter. However, increases in IL-8 were significantly reduced 12 hours after exercise when CUR was inges

    DOI

  • Central artery stiffness is related to cerebral oxygenation hemodynamics during executive function tasks in healthy middle-aged and older adults.

    Ai Hamasaki, Nobuhiko Akazawa, Toru Yoshikawa, Kanae Myoenzono, Kaname Tagawa, Yuriko Sawano, Makoto Nishimura, Seiji Maeda

    Experimental gerontology   114   93 - 98  2018年12月  [査読有り]  [国際誌]

     概要を見る

    Age-related decreases in cognitive function, cerebral perfusion, and vascular function increase the risk of dementia. However, the effects of central artery stiffness on cerebral oxygenation hemodynamics during executive function tasks and executive function remain unclear. The aim of this cross-sectional study was to investigate the relationships among central artery stiffness, cerebral oxygenation hemodynamics during executive function tasks, and executive function in middle-aged and older adults. Sixty-two middle-aged and older adults (age range: 51-79 years) were recruited for this study. For each participant, we measured the carotid artery β-stiffness, oxygenated hemoglobin (oxy-Hb) signal change in the prefrontal cortex during the Stroop task, and Stroop interference time. Correlation analyses revealed that the carotid artery β-stiffness was significantly correlated with the Stroop interference time (r = 0.43, P < 0.001) and with the oxy-Hb signal change in the left (r = -0.38, P = 0.002), but not the right, prefrontal cortex. In addition, the Stroop interference time was significantly correlated with the oxy-Hb signal change in the left (r = -0.42, P = 0.001), but not the right, prefrontal cortex. The participants were divided into the low and high arterial stiffness groups according to the median value. We found that the Stroop interference time was significantly shorter (P = 0.006) and the oxy-Hb signal change in the left prefrontal cortex was significantly larger in the low arterial stiffness group than in the high arterial stiffness group (P = 0.011). In the low, but not the high, arterial stiffness group, the oxy-Hb signal change of the left prefrontal cortex during executive function tasks was significantly larger than the oxy-Hb signal change of the right prefrontal cortex (P = 0.014). These results suggest that increases in central artery stiffness are associated with decreases in oxygenation hemodynamics in the left prefrontal cortex during executive function tasks and reductions in executive function.

    DOI PubMed

  • 中年および高齢者の動脈硬化度および副腎ホルモンに及ぼす有酸素運動の作用(Effect of aerobic fitness on arterial stiffness and adrenal hormones in middle-aged and older adults)

    Akazawa Nobuhiko, Tanahashi Koichiro, Kosaki Keisei, Kumagai Hiroshi, Oikawa Satoshi, Hamasaki Ai, Maeda Seiji

    The Journal of Physical Fitness and Sports Medicine   7 ( 6 ) 365 - 365  2018年11月

  • 運動誘発性血管新生におけるmiR-23クラスターの役割(The role of miR-23 clusters in exercise-induced angiogenesis)

    Oikawa Satoshi, Wada Shogo, Lee Minjung, Maeda Seiji, Akimoto Takayuki

    The Journal of Physical Fitness and Sports Medicine   7 ( 6 ) 369 - 369  2018年11月

  • 住民主導による成人肥満者を対象とした減量支援プログラムの実行可能性

    水島 諒子, 笹井 浩行, 中田, 由夫, 小澤 多賀子, 前田清司, 田中喜代次

    健康支援   20 ( 1 ) 191 - 200  2018年09月  [査読有り]

  • 水泳選手における断眠が間欠的高強度運動パフォーマンスに及ぼす影響

    菅原愛, 赤澤暢彦, 崔英珠, 仙石泰雄, 前田清司

    体育の科学   68 ( 7 ) 543 - 545  2018年07月  [査読有り]

  • Effects of resistance training on arterial compliance and plasma endothelin-1 levels in healthy men

    Tagawa, K, Ra, S-G, Kumagai, H, Yoshikawa, T, Yoshida, Y, Takekoshi, K, Sakai, S, Miyauchi, T, Maeda, S

    Physiological research   67 ( Supplementum 1 ) S155 - S166  2018年06月  [査読有り]

     概要を見る

    Arterial compliance (AC) is an index of the elasticity of large arteries. Endothelial dysfunction has been reported to result in reduced arterial compliance, which represents increased arterial stiffness. A reduction in AC is elicited by high-intensity resistance training, however the mechanisms are obscure. Because a single bout of resistance exercise causes a transient increase in circulating plasma endothelin-1 in humans, some vasoconstrictors may play a role in the mechanisms. The present study aimed to investigate whether resistance training-induced decrease in AC is associated with changes in circulating vasoconstrictors levels in young men. Young sedentary men were assigned to control (n=5) or training (n=9) groups. The training group performed four-week high-intensity resistance training (weight training exercise; three sessions/week). We measured AC and plasma levels of endothelin-1, angiotensin II, and norepinephrine before and after intervention. Resistance training significantly decreased AC, whereas the changes in plasma levels of neither endothelin-1, nor angiotensin II, nor norepinephrine were significantly different between the control and the training groups. Moreo

  • Regular aerobic exercise and blood pressure in East Asians: A meta-analysis of randomized controlled trials

    Yutaka Igarashi, Nobuhiko Akazawa, Seiji Maeda

    Clinical and Experimental Hypertension   40 ( 4 ) 378 - 389  2018年05月  [査読有り]

     概要を見る

    The aim of this meta-analysis was to evaluate the effects of regular aerobic exercise on blood pressure in East Asians. The inclusion criteria of the randomized controlled trials were healthy East Asian adults, exercise group performing regular aerobic exercise and control group not exercising, and a description of the mean systolic blood pressure or diastolic blood pressure at rest. This study included 31 study groups and 1994 subjects. Pooled changes in blood pressure showed significant reductions (systolic blood pressure: −4.7 mmHg
    diastolic blood pressure: −3.2 mmHg). In subgroup analyses, the change in systolic blood pressure for randomized controlled trials meeting the America Heart Association and American College of Sports Medicine guidelines for physical activity to maintain health was significantly larger than in randomized controlled trials not meeting the guidelines. In addition, meta-regression indicated that the change in systolic blood pressure was significantly related to “exercise time × exercise frequency.” The ideal volume of exercise is that for a long time at a high frequency, such as the volume recommended in the America Heart Association and American College of Sports Medicine guidelines: moderate intensity and &gt
    150 min per week. List of abbreviations: BP: blood pressure
    BMI: body mass index
    SBP: systolic blood pressure
    DBP: diastolic blood pressure
    RCT: randomized controlled trial
    AHA: America Heart Association
    ACSM: America College of Sports Medicine
    SD: standard deviation
    HDL-C: high-density lipoprotein cholesterol
    LDL-C: low-density lipoprotein cholesterol
    TC: total cholesterol
    TG: triglycerides
    PEDro: Physiotherapy Evidence Database
    CI: confidence intervals
    %HRmax: percentage of maximal heart rate.

    DOI

  • Sexual Function Is an Indicator of Central Arterial Stiffness and Arterial Stiffness Gradient in Japanese Adult Men

    Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Keisei Kosaki, Nobuhiko Akazawa, Zempo‐Miyaki Asako, Takehiko Tsujimoto, Tetsuhiro Kidokoro, Kiyoji Tanaka, Seiji Maeda

    Journal of the American Heart Association   7 ( 10 )  2018年05月  [査読有り]

    DOI

  • A Strategy To Reduce The Dropout Rate In A Volunteer-led Community Weight-loss Program

    Mizushima, Ryoko, Nakata, Yoshio, Zuo, Xinyu, Maeda, Seiji, Tanaka, Kiyoji

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   50 ( 5::1 ) 70 - 70  2018年05月  [査読有り]

  • Resistance training-induced decrease in central arterial compliance is associated with decreased subendocardial viability ratio in healthy young men

    Kaname Tagawa, Youngju Choi, Song-Gyu Ra, Toru Yoshikawa, Hiroshi Kumagai, Seiji Maeda

    Applied Physiology, Nutrition, and Metabolism   43 ( 5 ) 510 - 516  2018年05月  [査読有り]

     概要を見る

    High-intensity resistance training decreases central arterial compliance (CAC). Subendocardial viability ratio (SEVR) is a useful tool that reflects the balance between coronary perfusion and left ventricular afterload. Animal studies have demonstrated that decreased CAC is associated with SEVR deterioration. Therefore, resistance training-induced decrease in CAC may be associated with changes in SEVR. The objective of the present study was to investigate the association between SEVR and CAC using both cross-sectional and longitudinal (i.e., resistance training) study designs. To achieve this, we first conducted a cross-sectional study to investigate the association between SEVR and CAC in 89 young men. Thereafter, a longitudinal study was performed to examine the effects of resistance training on SEVR and CAC in young men. A total of 28 young men were divided into 2 groups: control (n = 13) and training (n = 15). In the training group, subjects underwent supervised resistance training for 4 weeks (5 sets of 10 repetitions at 75% of 1-repetition maximum, 3 times/week). CAC and SEVR were then measured in all subjects. In the cross-sectional study, SEVR was significantly positively correlated with CAC, whereas resistance training significantly decreased both SEVR and CAC. Moreover, training-induced changes in CAC were significantly correlated with changes in SEVR. Thus, these results suggest that resistance training-induced decrease in CAC is associated with decreased SEVR in young men.

    DOI

  • Impact of Short-Term Training Camp on Aortic Blood Pressure in Collegiate Endurance Runners

    Tsubasa Tomoto, Jun Sugawara, Ai Hirasawa, Tomoko Imai, Seiji Maeda, Shigehiko Ogoh

    Frontiers in Physiology   9  2018年03月

    DOI

  • Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and older-aged adults

    Maeda,Seiji

    Clinical and Experimental Hypertension   40 ( 3 ) 244 - 250  2018年03月  [査読有り]  [国際誌]

    DOI PubMed

  • Effect of novel recovery garments utilising nanodiamond- and nanoplatinum-coated materials (DPV576-C) on physical and psychological stress in baseball players: A randomised, placebo-controlled trial

    Choi, Youngju, Makita, Mizuho, Nakamura, Yuki, Yamatomo, Kousaku, Nara, Takaaki, Kawamura, Takashi, Fukuda, Hidehiro, Katano, Hideki, Miyakawa, Shumpei, Maeda, Seiji

    European journal of sport science   19 ( 7 ) 869 - 875  2018年03月

     概要を見る

    Based on research suggesting that nanomaterial containing nanodiamond- and nanoplatinum-coated fibres (DPV576-C) may reduce the stress response, garments to enhance athletes' recovery from training-induced stress have been manufactured. This study examined the effects of wearing recovery garments on the physical and psychological stress of Japanese male baseball players. Thirty-eight players aged 18-21 (19.6 ± 0.2 years) who participated in a two-week intensified training programme were randomly assigned to two groups: 19 wore recovery (DPV576-C) garments (RG group) and 19 wore non-recovery garments (placebo group). Both groups wore the garments overnight. Mood states, using the Profile of Mood States questionnaire, and salivary cortisol levels were measured before (day 0) and after (day 14) the training period. Saliva samples were collected from 07:00-07:30 am. Both groups' fatigue scores significantly increased after the training period (RG: 8.4 ± 0.8-10.1 ± 0.8 score; placebo: 9.8 ± 1.0-11.7 ± 1.0 score). The total mood disturbance (TMD) score increased significantly in the placebo group (21.0 ± 2.3-27.2 ± 3.0 score) but not in the RG group (17

    DOI

  • Effects of endothelin-related gene polymorphisms and aerobic exercise habit on age-related arterial stiffening: A 10-yr longitudinal study

    Jun Sugawara, Tsubasa Tomoto, Naohiro Noda, Satoko Matsukura, Kazuya Tsukagoshi, Koichiro Hayashi, Mutsuko Hieda, Seiji Maeda

    Journal of Applied Physiology   124 ( 2 ) 312 - 320  2018年02月  [査読有り]

     概要を見る

    Increased arterial stiffness has emerged as a strong predictor of future cardiovascular events and all-cause mortality. The aim of this study was to elucidate influences of endothelin (ET)-related genetic polymorphisms and regular physical activity on age-related arterial stiffening through a 10-yr longitudinal study. A decadal change in brachial-ankle pulse wave velocity (baPWV), an index of arterial stiffness, was evaluated retrospectively among 92 volunteers (63 ± 14 yr, 51 men). The targeted single-nucleotide polymorphisms were ET-A receptor SNP rs5333 (ET-A) and ET-B receptor SNP rs5351 (ET-B). Subjects with either ET-A TC or CC genotypes exhibited significantly greater increases in baPWV (+ 15.3 ± 11.7 and +16.6 ± 15.7%/dec, respectively) than ET-A TT genotype holders (+9.2 ± 9.0%/dec), whereas subjects with the ET-B GG genotype showed a significantly greater increase in baPWV (+17.7 ± 14.1%/dec) than other ET-B genotype holders (AA: +9.5 ± 10.0%/dec
    AG: + 11.2 ± 9.6%/dec). The combination of these ET-related genetic risks was associated with a 2.4 times greater decadal increase in baPWV compared with no genetic risk (+ 8.1 ± 8.4 vs. 19.5 ± 16.0%/dec). In contrast, individuals engaging in &gt
    15 METs·h/wk of aerobic exercise showed substantially smaller increases in baPWV (+5.0 ± 9.7%/dec) compared with their physically inactive peers (approximately +13%/dec). These differences remained significant after adjusting for confounding factors, including baseline baPWV and ET-related genotype risk. Our current longitudinal study found that ET-related gene polymorphisms contribute to diverse age-related changes in arterial stiffness, and that regular sufficient aerobic exercise attenuates the age-related arterial stiffening independently of ET-related gene polymorphisms.

    DOI

  • Relationship between aortic compliance and impact of cerebral blood flow fluctuation to dynamic orthostatic challenge in endurance athletes

    Tsubasa Tomoto, Tomoko Imai, Shigehiko Ogoh, Seiji Maeda, Jun Sugawara

    Frontiers in Physiology   9   9 - 25  2018年01月  [査読有り]

     概要を見る

    Aorta effectively buffers cardiac pulsatile fluctuation generated from the left ventricular (LV) which could be a mechanical force to high blood flow and low-resistance end-organs such as the brain. A dynamic orthostatic challenge may evoke substantial cardiac pulsatile fluctuation via the transient increases in venous return and stroke volume (SV). Particularly, this response may be greater in endurance-trained athletes (ET) who exhibit LV eccentric remodeling. The aim of this study was to determine the contribution of aortic compliance to the response of cerebral blood flow fluctuation to dynamic orthostatic challenge in ET and age-matched sedentary (SED) young healthy men. ET (n = 10) and SED (n = 10) underwent lower body negative pressure (LBNP) (-30 mmHg for 4 min) stimulation and release the pressure that initiates a rapid regain of limited venous return and consequent increase in SV. The recovery responses of central and middle cerebral arterial (MCA) hemodynamics from the release of LBNP (~15 s) were evaluated. SV (via Modeflow method) and pulsatile and systolic MCA (via transcranial Doppler) normalized by mean MCA velocity (MCAv) significantly increased after the cessation of LBNP in both groups. ET exhibited the higher ratio of SV to aortic pulse pressure (SV/AoPP), an index of aortic compliance, at the baseline compared with SED (P &lt
    0.01). Following the LBNP release, SV was significantly increased in SED by 14 ± 7% (mean ± SD) and more in ET by 30 ± 15%
    nevertheless, normalized pulsatile, systolic, and diastolic MCAv remained constant in both groups. These results might be attributed to the concomitant with the increase in aortic compliance assessed by SV/AoPP. Importantly, the increase in SV/AoPP following the LBNP release was greater in ET than in SED (P &lt
    0.01), and significantly correlated with the baseline SV/AoPP (r = 0.636, P &lt
    0.01). These results suggest that the aortic compliance in the endurance athletes is able to accommodate the additional SV and buffer the potential increase in pulsatility at end-organs such as the brain.

    DOI

  • Impact of leg heating on central hemodynamics in postmenopausal women

    Keisei Kosaki, Jun Sugawara, Asako Zempo-Miyaki, Seiji Maeda

    Artery Research   21 ( C ) 53 - 53  2018年

    DOI

  • Effect of habitual exercise on urinary liver-type fatty acid-binding protein levels in middle-aged and older adults

    K. Kosaki, A. Kamijo-Ikemori, T. Sugaya, K. Tanahashi, Y. Sawano, N. Akazawa, S. G. Ra, K. Kimura, Y. Shibagaki, S. Maeda

    Scandinavian Journal of Medicine and Science in Sports   28 ( 1 ) 152 - 160  2018年01月  [査読有り]

     概要を見る

    The purpose of this study was to examine the effect of habitual exercise on urinary liver-type fatty acid-binding protein (L-FABP), which can reflect the degree of various stresses on renal proximal tubule related to the progression of renal disease, in middle-aged and older adults. Cross-sectional and interventional approaches were used to comprehensively achieve this purpose. In the cross-sectional study, we investigated the relationship between physical activity levels and urinary L-FABP levels in 130 middle-aged and older adults. In the interventional study, subjects (n=31) were divided into two groups: exercise (n=19) and control group (n=12), whereby we examined the effects of 12-week aerobic exercise training on urinary L-FABP levels. The cross-sectional study showed that the urinary L-FABP levels were significantly lower in the higher physical activity group than in the lower physical activity group (P&lt
    .05). In the interventional study, 12-week aerobic exercise training significantly decreased urinary L-FABP levels (P&lt
    .01). Furthermore, the relative changes in urinary L-FABP levels were significantly correlated with the relative changes in physical activity levels and mean arterial pressure after intervention (r=−.374 and r=.530, respectively). Our results revealed that the urinary L-FABP levels were lower in the higher physical activity individuals, and aerobic exercise training decreased urinary L-FABP levels. These results suggest that habitual exercise appears to be associated with a decrease in the degree of several stresses on renal proximal tubule and to be beneficial for kidney health in middle-aged and older adults.

    DOI PubMed

  • The effect of sleep on motor skill learning in young badminton players aged 6–9 years

    Youngju Choi, Ryuchiro Sadamune, Yuki Nakamura, Masashi Suita, Shumpei Miyakawa, Seiji Maeda

    Sleep and Biological Rhythms   16 ( 1 ) 141 - 147  2018年01月  [査読有り]

     概要を見る

    The objective of this study was to examine the effect of sleep on the acquisition of motor skills in young badminton players. Thirteen badminton players, aged 6–9 years (8.0 ± 0.3 years
    mean ± SE), practiced the shuttle bouncing drill, and a skill none of the players had prior experience with. After practice sessions, shuttle bouncing performance was immediately tested and then retested 1 week later. We evaluated sleep parameters for 7 consecutive days using actigraphy. Using the median value of sleep efficiency, subjects were divided into two groups: good sleepers and poor sleepers. Good sleepers had shorter sleep latency (p &lt
    0.05), longer wake after sleep onset (p &lt
    0.001), longer total sleep time (p &lt
    0.005), and higher sleep efficiency (p &lt
    0.001) than the poor sleepers. Interestingly, improvement in shuttle bouncing performance was significantly greater in the good sleeper group than that in the poor sleeper group (p &lt
    0.05). In addition, we found that changes in the shuttle bouncing performance positively correlated with sleep efficiency (β = 0.765, p &lt
    0.01) and total sleep time (β = 0.588, p &lt
    0.05) after adjusting for their badminton career. These data suggest that sleep may affect the acquisition of motor skills in young players.

    DOI

  • Influence of sympathetic vasoconstrictor tone on conduit artery retrograde and oscillatory shear: effects of habitual aerobic exercise in middle-aged and older adults

    Maeda,Seiji

    The Journal of Physical Fitness and Sports Medicine   7 ( 1 ) 19 - 24  2018年01月  [査読有り]

  • Effect of endothelial microRNAs on blood pressure homeostasis

    Maeda,Seiji

    The Journal of Physical Fitness and Sports Medicine   7 ( 1 ) 41 - 45  2018年01月  [査読有り]

  • Vigorous Physical Activity is Associated with Regular Aerobic Exercise-Induced Increased Serum Testosterone Levels in Overweight/Obese Men

    Hiroshi Kumagai, Toru Yoshikawa, Asako Zempo-Miyaki, Kanae Myoenzono, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    Hormone and Metabolic Research   50 ( 01 ) 73 - 79  2018年01月  [査読有り]

     概要を見る

    <title>Abstract</title>Testosterone is a male sex hormone and low circulating testosterone levels are associated with various health disorders in men. Obesity results in reduced circulating testosterone levels in men. Previously, we demonstrated that lifestyle modifications (combination of aerobic exercise and dietary modification) increase circulating testosterone levels in overweight/obese men. However, the effect of regular aerobic exercise on serum testosterone levels remains unclear. The purpose of this study was to investigate the effect of a 12-week aerobic exercise intervention on circulating testosterone levels in normal-weight and overweight/obese men. Sixteen normal-weight men and twenty-eight overweight/obese men completed a 12-week aerobic exercise intervention. Before and after the intervention, we measured serum total testosterone, free testosterone, and bioavailable testosterone levels, and categorized the physical activity levels (light, moderate, or vigorous) in all participants. At baseline, serum total testosterone, free testosterone, and bioavailable testosterone levels were significantly lower in overweight/obese men than in normal-weight men (all p&lt;0.01). After the 12-week aerobic exercise intervention, serum total testosterone, free testosterone, and bioavailable testosterone levels significantly increased in overweight/obese men (p&lt;0.01). In addition, stepwise multivariable linear regression analysis revealed the increase in vigorous physical activity was independently associated with increased serum total testosterone levels (β=0.47, p=0.011). We demonstrated that a 12-week aerobic exercise intervention increased serum total testosterone, free testosterone, and bioavailable testosterone levels in overweight/obese men. We suggest that an increase in vigorous physical activity increased circulating testosterone levels in overweight/obese men.

    DOI

  • Which cytokine is the most related to weight loss-induced decrease in arterial stiffness in overweight and obese men?

    Hiroshi Kumagai, Asako Zempo-Miyaki, Toru Yoshikawa, Miki Eto, Rina So, Takehiko Tsujimoto, Takeshi Nishiyasu, Kiyoji Tanaka, Seiji Maeda

    Endocrine Journal   65 ( 1 ) 53 - 61  2018年  [査読有り]

    DOI

  • Relationships between serum free fatty acid and pulse pressure amplification in overweight/obese men: insights from exercise training and dietary modification

    Toru Yoshikawa, Asako Zempo-Miyaki, Hiroshi Kumagai, Kanae Myoenzono, Rina So, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    Journal of Clinical Biochemistry and Nutrition   62 ( 3 ) 254 - 258  2018年  [査読有り]

    DOI

  • Habitual exercise decreases plasma xanthine oxidoreductase activity in middle-Aged and older women

    Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Koichiro Tanahashi, Nobuhiko Akazawa, Chihiro Hibi, Takashi Nakamura, Takayo Murase, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda

    Journal of Clinical Biochemistry and Nutrition   62 ( 3 ) 247 - 253  2018年  [査読有り]

     概要を見る

    The aim of present study was to investigate the association plasma xanthine oxidoreductase activity, which has gained attention as a novel preventive target of cardiovascular disease, and various physiological parameters and was to determine the effects of habitual exercise on plasma xanthine oxidoreductase activity in middle-Aged and older women. In the cross-sectional study, we investigated the association between plasma xanthine oxidoreductase activity and various physiological parameters in 94 middle-Aged and older women. In the interventional study, subjects (n = 22) were divided into two groups: exercise (n = 12) or the control group (n = 10), whereby we examined the effect of 12-week aerobic exercise training on plasma xanthine oxidoreduc- tase activity in middle-Aged and older women. The cross-sectional study demonstrated that plasma xanthine oxidoreductase activity was significantly associated with various physiological parameters, including visceral fat and daily step counts. In the interventional study, the plasma xanthine oxidoreductase activity significantly decreased after the 12-week aerobic exercise training, its changes were inversely associated with the changes in daily step counts. Our results revealed that the plasma xanthine oxidoreductase activity was associated with visceral fat accumulation and lack of exercise, and it was decreased by the aerobic exercise training.

    DOI

  • Relationships between serum free fatty acid and pulse pressure amplification in overweight/obese men: insights from exercise training and dietary modification

    Toru Yoshikawa, Asako Zempo-Miyaki, Hiroshi Kumagai, Kanae Myoenzono, Rina So, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    Journal of Clinical Biochemistry and Nutrition   62 ( 3 ) 254 - 258  2018年  [査読有り]

    DOI

  • Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults

    Akazawa N, Hamasaki A, Tanahashi K, Kosaki K, Yoshikawa T, Myoenzono K, Maeda S

    Nutr Res    2018年  [査読有り]

  • Effects of resistance training on arterial compliance and plasma endothelin-1 levels in healthy men

    Tagawa K, Ra SG, Kumagai H, Yoshikawa T, Yoshida Y, Takekoshi K, Sakai S, Miyauchi T, Maeda S

    Physiol Res    2018年  [査読有り]

  • Lactotripeptides supplementations alleviate the decrease in maximal isometric force following high-intensity eccentric exercise: a randomized, placebo-controlled, double-blinded clinical trial

    Tagawa K, Ra SG, Choi Y, Maeda S

    Am J Phys Med Rehabil    2018年  [査読有り]

  • Aerobic exercise training enhances cerebrovascular pulsatility response to acute aerobic exercise in older adults

    Akazawa N, Tanahashi K, Kosaki K, Ra SG, Matsubara T, Choi Y, Zempo-Miyaki A, Maeda S

    Physiol Rep    2018年  [査読有り]

  • Hemodynamic response to unilateral resistance exercise with lactotripeptides

    Ra SG, Tagawa K, Choi Y, Maeda S

    Gazzetta Medica Italiana    2018年  [査読有り]

  • Age-related declines in excutive function and cerebral oxygenation hemodynamics

    Hamasaki A, Akazawa N, Yoshikawa T, Myoenzono K, Tagawa K, Maeda S

    Tohoku J Exp Med    2018年  [査読有り]

  • Resistance training-induced decreases in central arterial compliance is associated with increases in serum thromboxane B2 concentrations in young men

    Kaname Tagawa, Song-Gyu Ra, Hiroshi Kumagai, Yuriko Sawano, Kosaku Yamamoto, Toru Yoshikawa, Youngju Choi, Yasuko Yoshida, Kazuhiro Takekoshi, Seiji Maeda

    Artery Research   23 ( C ) 63 - 63  2018年  [査読有り]

    DOI

  • Role of endothelial microRNA-23 clusters in angiogenesis in vivo

    Oikawa S, Wada S, Lee M, Maeda S, Akimoto T

    Am J Physiol Heart Circ Physiol    2018年  [査読有り]

  • The required step count for a reduction in blood pressure: A systematic review and meta-analysis

    Igarashi Y, Akazawa N, Maeda S

    J Human Hypertens    2018年  [査読有り]

  • 低体重高齢者における低強度レジスタンストレーニングとL-シトルリン含有組成物摂取の併用が中心血行動態に及ぼす影響

    田川要, 赤澤暢彦, 吉川徹, 鈴木貴視, 森田匡彦, 大藏倫博, 前田清司

    健康支援    2018年  [査読有り]

  • 断眠が水泳の間欠的高強度運動パフォーマンスに及ぼす影響

    菅原愛, 赤澤暢彦, 崔英珠, 仙石泰雄, 前田清司

    体育の科学    2018年  [査読有り]

  • 住民主導による成人肥満者を対象とした減量支援プログラムの実行可能性

    水島諒子, 笹井浩行, 中田由夫, 小澤多賀子, 前田清司, 田中喜代次

    健康支援    2018年  [査読有り]

  • 習慣的な運動による老化関連疾患の予防

    小﨑恵生, 前田清司

    医学のあゆみ    2018年

  • 競技力を高める時差ボケ対策

    Elisabeth, Petit, 中村優希, Lucas Garbellotto, 前田清司, Fabienne Mougin

    体育の科学    2018年

  • Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men

    Toru Yoshikawa, Hiroshi Kumagai, Kanae Myoenzono, Asako Zempo-Miyaki, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    ARTERY RESEARCH   20   27 - 34  2017年12月  [査読有り]

     概要を見る

    Background: Postprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders. The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism.
    Methods: Fifteen overweight/obese men (mean +/- SD; age, 52 +/- 10 years; BMI, 29.1 +/- 2.3 kg/m(2)) completed a 12-week dietary modification program (group lectures and individual counseling conducted 8 times in 12 weeks, 1680 kcal/day). Before and after the program, body mass, daily intakes of total energy and major macronutrients, serum lipid profiles, and homeo-stasis model assessment for insulin resistance (HOMA-IR) were measured, and plasma glucose, serum insulin, and cSBP (i.e., radial second systolic pressure) were assessed when fasting and at 60 min and 120 min after 75 g oral glucose loading.
    Results: The 12-week program led to successful weight loss (-10.1 kg or -12.1%) with significant reductions in the daily intakes of total energy and major macronutrients. Consequently, low-density lipoprotein cholesterol, triglycerides, HOMA-IR (2.1 +/- 1.3 to 0.8 +/- 0.3, p &lt; 0.01), and glucose and insulin during OGTT were substantially decreased after 12 weeks. The diet program had also resulted in significantly reduced 2-h averaged cSBP during OGTT ( 111 +/- 11 to 103 +/- 10 mmHg, p &lt; 0.01). There was a significant correlation between the changes from baseline in both HOMA-IR and 2-h averaged cSBP (r(s) = 0.69, p &lt; 0.01).
    Conclusions: The current results suggest that the dietary modification-induced improvement in insulin resistance has contributed to a significant reduction in cSBP during OGTT in over-weight/obese men. (C) 2017 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.

    DOI

  • Effects of aerobic and resistance training combined with fortified milk on muscle mass, muscle strength, and physical performance in older adults: A randomized controlled trial

    Yosuke Osuka, S. Fujita, N. Kitano, K. Kosaki, J. Seol, Y. Sawano, H. Shi, Y. Fujii, S. Maeda, T. Okura, H. Kobayashi, K. Tanaka

    JOURNAL OF NUTRITION HEALTH & AGING   21 ( 10 ) 1349 - 1357  2017年12月  [査読有り]

     概要を見る

    Fortified milk and resistance training (RT) increase muscle mass, muscle strength, and physical performance in older adults, but it remains unclear whether RT combined with aerobic training (AT) would have stronger effects on these outcomes. The purpose of this study was to examine the effects of aerobic and resistance training (ART) combined with fortified milk consumption on muscle mass, muscle strength, and physical performance in older adults.
    Open-labeled randomized controlled trial. Setting: University of Tsukuba.
    Fifty-six older adults aged 65-79.
    Participants were randomly allocated into resistance training (RT + fortified milk, n = 28) and aerobic and resistance training (ART + fortified milk, n = 28) groups. All participants attended supervised exercise programs twice a week at University of Tsukuba and ingested fortified milk every day for 12 weeks. Skeletal muscle index ([SMI]: appendicular lean mass/ height(2)) was assessed using dual-energy X-ray absorptiometry as a muscle mass measure. One-repetition maximum strength was measured using four kinds of resistance training machines (chest press, leg extension, leg curl, and leg press) as muscle strength measures. Sit-to-stand and arm curl tests were also assessed as physical performance measures.
    The primary measurements were muscle mass and strength. The secondary outcomes were physical performance, blood samples, habitual diet, habitual physical activity, and medication use.
    Although the muscle strength and physical performance measures significantly improved in both groups, SMI significantly improved in only the RT group. There was no significant difference in the change in SMI and muscle strength measures between the two groups. However, the change in sit-to-stand and arm curl measures in the ART group were significantly higher than those in the RT group.
    These results suggest that AT before RT combined with fortified milk consumption has similar effects on skeletal muscle mass and strength compared with RT alone, but it may be a more useful strategy to improve physical performance in older adults. Although the mechanism of our intervention is uncertain, our program would be an effective prevention for sarcopenia in older adults.

    DOI

  • THE EFFECTS OF BRIGHT LIGHT EXPOSURE AT NIGHT ON CIRCADIAN RHYTHMS AND ENERGY METABOLISM

    Choi, Y, Akazawa, N, Nakamura, Y, Park, I, Tokuyama, K, Maeda, S

    SLEEP MEDICINE   40 ( 1 ) E64 - E64  2017年12月  [査読有り]

  • 運動による骨格筋順応におけるマイクロRNAの関与(Involvement of microRNAs in exercise-induced skeletal muscle adaptation)

    Oikawa Satoshi, Maeda Seiji

    The Journal of Physical Fitness and Sports Medicine   6 ( 6 ) 421 - 421  2017年11月

  • レジスタンストレーニングに誘発される血清thromboxane濃度増加は若年男性の中心動脈コンプライアンス低下と関連する(Resistance training-induced increased serum thromboxane concentrations are associated with decreased central arterial compliance in young men)

    Tagawa Kaname, Ra Song-Gyu, Kumagai Hiroshi, Sawano Yuriko, Yamamoto Kosaku, Yoshikawa Toru, Yoshida Yasuko, Takekoshi Kazuhiro, Maeda Seiji

    The Journal of Physical Fitness and Sports Medicine   6 ( 6 ) 504 - 504  2017年11月  [査読有り]

  • Relationship between exercise capacity and urinary liver-type fatty acid-binding protein in middle-aged and older individuals

    Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Koichiro Tanahashi, Hiroshi Kumagai, Yuriko Sawano, Nobuhiko Akazawa, Song-Gyu Ra, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   21 ( 5 ) 810 - 817  2017年10月  [査読有り]

     概要を見る

    The underlying mechanism linking the decline in exercise capacity with renal dysfunction remains unclear. Urinary liver-type fatty acid-binding protein (L-FABP) levels reflect the degree of peritubular capillary blood flow, an important factor for renal dysfunction with aging. The aim of this study was to examine the relationship between exercise capacity and urinary L-FABP levels.
    This was a cross-sectional study of 187 middle-aged and older individuals (aged 50-83 years) without chronic kidney disease (CKD). We assessed urinary L-FABP levels, peak oxygen consumption (), and grip strength.
    Urinary L-FABP levels inversely correlated with both (r (s) = -0.349) and grip strength (r (s) = -0.485). When the participants were divided into four groups according to the median values of aerobic fitness and muscular strength ( and grip strength), urinary L-FABP levels were the highest in participants with lower levels of aerobic fitness and muscular strength (2.95 +/- 1.43 mu g/g creatinine) and the lowest in the participants with higher levels of aerobic fitness and muscular strength (1.33 +/- 0.76 mu g/g creatinine). The difference between the two groups was significant (P &lt; 0.001).
    Our results demonstrate that both and grip strength were inversely associated with urinary L-FABP levels in middle-aged and older individuals without CKD. This suggests that a decline in exercise capacity is associated with a reduction in peritubular capillary blood flow, providing a novel insight into the underlying mechanism linking the decline in exercise capacity to the development of renal dysfunction.

    DOI

  • 運動による動脈硬化の予防・改善

    前田,清司

    体育の科学   67 ( 10 ) 682 - 685  2017年10月

  • 中高齢者における有酸素性運動介入が脳血流動態および認知機能に与える影響

    濱崎 愛, 赤澤 暢彦, 栃木 悠里子, 吉川 徹, 妙圓園 香苗, 西村 真琴, 棚橋 嵩一郎, 前田 清司

    脳科学とリハビリテーション   17   50 - 50  2017年09月

  • Effect of Chlorella-derived multicomponent supplementation on maximal oxygen uptake and serum vitamin B-2 concentration in young men

    Asako Zempo-Miyaki, Seiji Maeda, Takeshi Otsuki

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   61 ( 2 ) 135 - 139  2017年09月  [査読有り]

     概要を見る

    Chlorella is a unicellular green alga that contains high levels of proteins, vitamins and minerals. The present study investigated the effects of a 4-week Chlorella-derived multicomponent supplementation on maximal oxygen uptake and circulating vitamin B-2 levels in healthy men. Thirty-four participants were randomly divided into two groups: placebo or Chlorella. Prior to the intervention, we observed that the intake of several minerals and soluble vitamins did not satisfy the nutrient requirements of either group by assessing the frequency of daily food intake. There was a significant negative relationship between the pre-intervention maximal oxygen uptake and serum vitamin B-2 concentrations in all subjects (r = -0.372). Maximal oxygen uptake significantly increased after Chlorella supplementation (before vs after, 42.1 +/- 1.5 vs 44.9 +/- 1.6 ml/kg/min), while serum vitamin B-2 concentrations did not (14.6 +/- 0.9 vs 14.0 +/- 0.9 mu g/L). In conclusion, Chlorella-derived multicomponent supplementation increases maximal oxygen uptake in individuals with an insufficient micro nutrient status, although there was no association between the increase in aerobic capacity and serum levels of vitamin B-2.

    DOI

  • バドミントン競技選手における睡眠の質がパフォーマンスに与える影響

    前田,清司

    トレーニング科学   28   183 - 189  2017年09月  [査読有り]

  • 運動誘発性疲労マーカーとしての唾液中タウリンの可能性

    前田,清司

    タウリンリサーチ   3 ( 1 ) 6 - 8  2017年09月

  • 陸上競技女子長距離選手における貧血状態と血中アミノ酸濃度の関連

    前田,清司

    体力科学   66 ( 6 ) 391 - 397  2017年08月  [査読有り]

  • Relation between arterial stiffness and aerobic capacity: Importance of proximal aortic stiffness

    Tsubasa Tomoto, Seiji Maeda, Jun Sugawara

    EUROPEAN JOURNAL OF SPORT SCIENCE   17 ( 5 ) 571 - 575  2017年06月  [査読有り]

     概要を見る

    Brachial-ankle pulse wave velocity (baPWV) has become a popular modality of arterial stiffness measurement. However, its projected arterial segment does not include the proximal aorta which plays important roles for attenuating cardiac pulsation and reducing afterload. We hypothesised that aerobic capacity would be more strongly associated with PWV including the proximal aorta than that omitting the proximal aorta. To test our hypothesis, we compared the association between aerobic capacity and arterial stiffness parameters omitting vs. including the proximal aorta (i.e. baPWV vs. heart-ankle PWV [haPWV]) in 82 apparently healthy men (18-64 years). Estimated VO2max significantly correlated with baPWV (r = -0.394, P &lt; .001), and more strongly with haPWV (r = -0.546, P &lt; .001). The forward stepwise multi-regression analysis revealed that haPWV (beta = -0.335), as well as age, heart rate, and body mass index (beta = -0.280 to -0.297), was a significant independent determinant explaining variance of estimated VO2max. These results suggest that aerobic capacity is influenced more strongly by the proximal aortic stiffness than distal aortic stiffness.

    DOI

  • Impact of mild orthostatic stress on aortic-cerebral hemodynamic transmission: insight from the frequency domain

    Jun Sugawara, Tsubasa Tomoto, Tomoko Imai, Seiji Maeda, Shigehiko Ogoh

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   312 ( 5 ) H1076 - H1084  2017年05月  [査読有り]

     概要を見る

    High cerebral pressure and flow fluctuations could be a risk for future cerebrovascular disease. This study aims to determine whether acute systemic vasoconstriction affects the dynamic pulsatile hemodynamic transmission from the aorta to the brain. We applied a stepwise lower body negative pressure (LBNP) (-10, -20, and -30 mmHg) in 15 young men to induce systemic vasoconstriction. To elucidate the dynamic relationship between the changes in aortic pressure (AoP; estimated from the radial arterial pressure waveforms) and the cerebral blood flow velocity (CBFV) at the middle cerebral artery (via a transcranial Doppler), frequency-domain analysis characterized the beat-to-beat slow oscillation (0.02-0.30 Hz) and the intra-beat rapid change (0.78-9.69 Hz). The systemic vascular resistance gradually and significantly increased throughout the LBNP protocol. In the low-frequency range (LF: 0.07-0.20 Hz) of a slow oscillation, the normalized transfer function gain of the steady-state component (between mean AoP and mean CBFV) remained unchanged, whereas that of the pulsatile component (between pulsatile AoP and pulsatile CBFV) was significantly augmented during -20 and -30 mmHg of LBNP (+28.8% and +32.4% vs. baseline). Furthermore, the relative change in the normalized transfer function gain of the pulsatile component at the LF range correlated with the corresponding change in systemic vascular resistance (r = 0.41, P = 0.005). Regarding the intra-beat analysis, the normalized transfer function gain from AoP to CBFV was not significantly affected by the LBNP stimulation (P = 0.77). Our findings suggest that systemic vasoconstriction deteriorates the dampening effect on the pulsatile hemodynamics toward the brain, particularly in slow oscillations (e.g., 0.07-0.20 Hz).
    NEW & NOTEWORTHY We characterized the pulsatile hemodynamic transmission from the heart to the brain by frequency-domain analysis. The low-frequency transmission was augmented with a mild LBNP stimulation partly due to the elevated systemic vascular resistance. A systemic vasoconstriction deteriorates the dampening effect on slow oscillations of pulsatile hemodynamics toward the brain.

    DOI

  • Association between muscular strength and intrarenal vascular resistance in middle-aged and older individuals

    Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Koichiro Tanahashi, Hiroshi Kumagai, Yuriko Sawano, Yosuke Osuka, Kiyoji Tanaka, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda

    EXPERIMENTAL GERONTOLOGY   91   72 - 78  2017年05月  [査読有り]

     概要を見る

    A strategy for the preservation of intrarenal vasculature conditions remains obscure in middle-aged and older individuals without the renal disease. In the present study, we sought to identify whether the maintenance of muscular strength is an effective method of preserving the intrarenal vasculature condition of middle-aged and older individuals. Therefore, we applied a cross-sectional approach for investigating the relationship between muscular strength and the condition of the intrarenal vasculature. In 169 middle-aged and older individuals without renal disease, handgrip strength (HGS) and the renal resistive index (RRI) were measured as the parameters of muscular strength and intrarenal vascular resistance, respectively. The RRI was elevated with aging (r(s) = 0.499, P &lt; 0.001) and was inversely correlated with HGS (r(s) = 0.370, P &lt; 0.001). The relationship between RRI and HGS remained significant after the consideration of confounders, including age and various central hemodynamic parameters. Furthermore, when the individuals were divided into four groups according to age (middle-aged or older) and the median HGS values, the RRI exhibited the highest values in the older group with lower HGS values (P &lt; 0.001). Our findings indicate that muscular strength as assessed by HGS is independently associated with the RRI (i.e. intrarenal vascular resistance) in middle-aged and older individuals. This finding suggests that the muscular strength may be one of the key factors to preserve the intrarenal vasculature condition. (C) 2017 Elsevier Inc. All rights reserved.

    DOI

  • Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

    Hirofumi Misu, Hiroaki Takayama, Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi, Kiyo-aki Ishii, Keita Chikamoto, Takehiro Kanamori, Natsumi Tajima, Fei Lan, Yumie Takeshita, Masao Honda, Mutsumi Tanaka, Seiji Kato, Naoto Matsuyama, Yuya Yoshioka, Kaito Iwayama, Kumpei Tokuyama, Nobuhiko Akazawa, Seiji Maeda, Kazuhiro Takekoshi, Seiichi Matsugo, Noriko Noguchi, Shuichi Kaneko, Toshinari Takamura

    NATURE MEDICINE   23 ( 4 ) 508 - +  2017年04月  [査読有り]

     概要を見る

    Exercise has numerous health-promoting effects in humans(1); however, individual responsiveness to exercise with regard to endurance or metabolic health differs markedly(2-4). This 'exercise resistance' is considered to be congenital, with no evident acquired causative factors. Here we show that the anti-oxidative hepatokine selenoprotein P (SeP)(5-7) causes exercise resistance through its muscle receptor low-density lipoprotein receptor-related protein 1 (LRP1)(8). SeP-deficient mice showed a 'super-endurance' phenotype after exercise training, as well as enhanced reactive oxygen species (ROS) production, AMP-activated protein kinase (AMPK) phosphorylation(9) and peroxisome proliferative activated receptor gamma coactivator (Ppargc)-1 alpha (also known as PGC-1 alpha; encoded by Ppargc1a)(10) expression in skeletal muscle. Supplementation with the anti-oxidant N-acetylcysteine (NAC) reduced ROS production and the endurance capacity in SeP-deficient mice. SeP treatment impaired hydrogen-peroxide-induced adaptations through LRP1 in cultured myotubes and suppressed exercise-induced AMPK phosphorylation and Ppargc1a gene expression in mouse skeletal muscle-effects which were blunted in mice with a muscle-specific LRP1 deficiency. Furthermore, we found that increased amounts of circulating SeP predicted the ineffectiveness of training on endurance capacity in humans. Our study suggests that inhibitors of the SeP-LRP1 axis may function as exercise-enhancing drugs to treat diseases associated with a sedentary lifestyle.

    DOI

  • ライフセーバーにおける水難救助活動期間中の睡眠と唾液SIgA分泌速度との関連

    前田,清司

    日本臨床スポーツ医会誌   25 ( 2 ) 261 - 268  2017年04月  [査読有り]

  • Relationship between anemia and circulating levels of amino acids in female endurance athletes

    Reiko Momma, Hiroshi Kumagai, Moe Oshiden, Motoyuki Iemitsu, Seiji Maeda

    Japanese Journal of Physical Fitness and Sports Medicine   66 ( 6 ) 391 - 397  2017年  [査読有り]

     概要を見る

    The symptoms of anemia, decreases in the levels of circulating red blood cells (RBC), hemoglobin (Hb) and hematocrit (Ht) lead to decrease endurance performance, and the risk of anemia increases in female endurance athletes. Although Hb is composed of a large amount of amino acids, the relationships between circulating levels of amino acids and RBC, Hb and Ht in female endurance athletes have not been clarified yet. Thus, the purpose of the present study was to investigate the relationship between circulating levels of amino acids and RBC, Hb and Ht in female endurance athletes. Twenty-four female endurance athletes (19.8 ± 0.2 years) participated in this study. We measured circulating levels of RBC, Hb and Ht from blood. Also, we measured circulating levels of amino acids from plasma by use of comprehensive analysis. The levels of circulating RBC, Hb and Ht in all subjects were within the normal range. We found that circulating taurine levels were significantly correlated with RBC (r = 0.48, p &lt
    0.05), Hb (r = 0.44, p &lt
    0.05) and Ht (r = 0.42, p &lt
    0.05) in female endurance athletes. In the present study, we demonstrated that circulating taurine levels were significantly associated with RBC, Hb and Ht in female endurance athletes. These results suggest that circulating taurine levels may be a predictor of anemia and treatment strategy for anemia.

    DOI

  • Influence of blood flow velocity on arterial distensibility of carotid artery in healthy men

    Tsubasa Tomoto, Seiji Maeda, Jun Sugawara

    JOURNAL OF PHYSIOLOGICAL SCIENCES   67 ( 1 ) 191 - 196  2017年01月  [査読有り]

     概要を見る

    Decreased distensibility of carotid artery is independently associated with the incidence of cardiovascular and cerebrovascular events. Arterial distensibility is determined by vascular tone. Since shear stress is an important driving force of vasodilatory substances production form endothelial cells, we hypothesized that local basal (i.e., resting) arterial blood flow velocity is associated with regional arterial distensibility. To test this hypothesis, we determined the influence of local blood flow velocity on carotid arterial distensibility in cross-sectional study design. In a total of 73 apparent healthy men (18-64 years), carotid arterial properties, including measures of carotid arterial distensibility and BFV at rest, were evaluated via B-mode and Doppler ultrasound imaging and applanation tonometry system. Carotid arterial peak BFV and the absolute and normalized pulsatile BFV significantly correlated with age (r = -0.453 to -0.600, p &lt; 0.0001), whereas mean and minimum BFV were not influenced by age. Distensibility coefficient of carotid artery correlated with peak BFV (r = 0.305, p &lt; 0.01) and more strongly with pulsatile (i.e., systolic minus end-diastolic) BFV (r = 0.406, p &lt; 0.0001) and the normalized pulsatile BFV by time-averaged velocity (r = 0.591, p &lt; 0.0001). Multi-regression analysis revealed that age (beta = -0.57, p &lt; 0.0001) was the primary independent determinant for distensibility coefficient. In addition with this, carotid lumen diameter (beta = -0.202, p &lt; 0.01) and the normalized pulsatile BFV (beta = 0.237, p &lt; 0.05) were significant independent determinants of distensibility coefficient. Qualitatively similar results (although inverse in direction) were obtained by use of beta-stiffness index. These results suggest that greater gradient of blood flow velocity during a cardiac cycle are favorably associated with distensibility of carotid artery.

    DOI

  • 若年女性における月経周期がバランス能力に及ぼす影響 –卵胞期と月経期における検討

    Maeda,Seiji

    体育の科学   67   65 - 69  2017年  [査読有り]

  • Central blood pressure is associated with trunk flexibility in older adults

    Miho Komatsu, Nobuhiko Akazawa, Koichiro Tanahashi, Hiroshi Kumagai, Toru Yoshikawa, Keisei Kosaki, Asako Zempo-Miyaki, Seiji Maeda

    Artery Research   19 ( C ) 91 - 91  2017年  [査読有り]

    DOI

  • Impact of Age and Aerobic Exercise Training on Conduit Artery Wall Thickness: Role of the Shear Pattern

    Koichiro Tanahashi, Keisei Kosaki, Yuriko Sawano, Toru Yoshikawa, Kaname Tagawa, Hiroshi Kumagai, Nobuhiko Akazawa, Seiji Maeda

    JOURNAL OF VASCULAR RESEARCH   54 ( 5 ) 272 - 279  2017年  [査読有り]

     概要を見る

    Hemodynamic shear stress is the frictional force of blood on the arterial wall. The shear pattern in the conduit artery affects the endothelium and may participate in the development and progression of atherosclerosis. We investigated the role of the shear pattern in age- and aerobic exercise-induced changes in conduit artery wall thickness via cross-sectional and interventional studies. In a cross-sectional study, we found that brachial shear rate patterns and brachial artery intima-media thickness (IMT) correlated with age. Additionally, brachial artery shear rate patterns were associated with brachial artery IMT in 102 middle-aged and older individuals. In an interventional study, 39 middle-aged and older subjects were divided into 2 groups: control and exercise. The exercise group completed 12 weeks of aerobic exercise training. Aerobic exercise training significantly increased the antegrade shear rate and decreased the retrograde shear rate and brachial artery IMT. Moreover, changes in the brachial artery antegrade shear rate and the retrograde shear rate correlated with the change in brachial artery IMT. The results of the present study indicate that changes in brachial artery shear rate patterns may contribute to age- and aerobic exercise training-induced changes in brachial artery wall thickness. (C) 2017 S. Karger AG, Basel

    DOI

  • Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults

    A. Zempo-Miyaki, S. Fujie, K. Sato, N. Hasegawa, K. Sanada, S. Maeda, T. Hamaoka, M. Iemitsu

    JOURNAL OF HUMAN HYPERTENSION   30 ( 9 ) 521 - 526  2016年09月  [査読有り]

     概要を見る

    Regular exercise improves aging-induced deterioration of arterial stiffness, and is associated with elevated production of pentraxin 3 (PTX3) and anti-inflammatory as well as anti-atherosclerotic effects. However, the time-dependent effect of exercise training on arterial stiffness and PTX3 production remains unclear. The purpose of this study was to investigate the time course of the association between the effects of training on the circulating PTX3 level and arterial stiffness in middle-aged and older adults. Thirty-two healthy Japanese subjects (66.2 +/- 1.3 year) were randomly divided into two groups: training (exercise intervention) and sedentary controls. Subjects in the training group completed 8 weeks of aerobic exercise training (60-70% peak oxygen uptake (VO2peak) for 45 min, 3 days per week); during the training period, we evaluated plasma PTX3 concentration and carotid-femoral pulse wave velocity (cfPWV) every 2 wk. cfPWV gradually declined over the 8-week training period, and was significantly reduced after 6 and 8 week of exercise intervention (P &lt; 0.05). Plasma PTX3 level was significantly increased after 4 weeks of the intervention (P &lt; 0.05). In addition, the exercise training-induced reduction in cfPWV was negatively correlated with the percent change in plasma PTX3 level after 6 week (r = -0.54, P &lt; 0.05) and 8 weeks (r = -0.51, P &lt; 0.05) of the intervention, but not correlated at 4 weeks. Plasma PTX3 level was elevated at the early stage of the exercise training intervention, and was subsequently associated with training-induced alteration of arterial stiffness in middle-aged and older adults.

    DOI

  • 集団型減量支援プログラムにおける減量効果と社会的支援の関係

    若葉 京良, 辻本 健彦, 趙 暁光, 王 震男, 谷口 亮介, 奥松 功基, 熊谷 仁, 吉川 徹, 妙圓園 香苗, 前田 清司, 田中 喜代次

    教育医学   62 ( 1 ) 94 - 95  2016年08月

  • ACUTE EFFECT OF HIGH-INTENSITY ECCENTRIC EXERCISE ON VASCULAR ENDOTHELIAL FUNCTION IN YOUNG MEN

    Youngju Choi, Nobuhiko Akazawa, Asako Zempo-Miyaki, Song-Gyu Ra, Hitoshi Shiraki, Ryuichi Ajisaka, Seiji Maeda

    JOURNAL OF STRENGTH AND CONDITIONING RESEARCH   30 ( 8 ) 2279 - 2285  2016年08月  [査読有り]

     概要を見る

    Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 +/- 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and b-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r = 0.779; p &lt;= 0.05), and a negative correlation was detected between change in b-stiffness index and change in FMD (r = 0.891; p &lt;= 0.01) with eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.

  • Changes in salivary flow rate following Chlorella-derived multicomponent supplementation

    Takeshi Otsuki, Kazuhiro Shimizu, Asako Zempo-Miyaki, Seiji Maeda

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   59 ( 1 ) 45 - 48  2016年07月  [査読有り]

     概要を見る

    Decreases in saliva secretion compromise food mastication and swallowing, reduce mucosal immune function, and increase the risk for oral diseases like dental caries. Chlorella is a green alga that contains a variety of nutrients including amino acids, vitamins, and minerals. In our previous study, Chlorella-derived multi component supplementation did not affect salivary flow rates in healthy young individuals, but Chlorella-derived supplementation attenuated a decrease in saliva secretion that was observed during a kendo training camp. Hence, we hypothesized that Chlorella-derived supplementation increases saliva secretion in individuals with lower rates of saliva flow. Sixty-four subjects took Chlorella-derived tablets for four weeks. Before and after supplementation, saliva samples were collected by chewing cotton. In the complete study group, there was no difference in saliva production before and after supplementation (1.91 +/- 0.11 ml/min before vs 2.01 +/- 0.12 ml/min after). Analysis of subgroups based on saliva production before supplementation found an increase in saliva secretion in the lower saliva flow group (1.18 +/- 0.06 vs 1.38 +/- 0.08 ml/min), but no change in the higher saliva flow group (2.63 +/- 0.11 vs 2.64 +/- 0.15 ml/min). These results suggest that Chlorella-derived multicomponent supplementation increases saliva production in individuals with lower levels of saliva secretion.

    DOI

  • Taurine supplementation attenuates delayed increase in exercise-induced arterial stiffness

    Song-Gyu Ra, Youngju Choi, Nobuhiko Akazawa, Hajime Ohmori, Seiji Maeda

    APPLIED PHYSIOLOGY NUTRITION AND METABOLISM   41 ( 6 ) 618 - 623  2016年06月  [査読有り]

     概要を見る

    There is a delayed increase in arterial stiffness after eccentric exercise that is possibly mediated by the concurrent delayed increase in circulating oxidative stress. Taurine has anti-oxidant action, and taurine supplementation may be able to attenuate the increase in oxidative stress after exercise. The purpose of the present study was to investigate whether taurine supplementation attenuates the delayed increase in arterial stiffness after eccentric exercise. In the present double-blind, randomized, and placebo-controlled trial, we divided 29 young, healthy men into 2 groups. Subjects received either 2.0 g of placebo (n = 14) or taurine (n = 15) 3 times per day for 14 days prior to the exercise, on the day of exercise, and the following 3 days. The exercise consisted of 2 sets of 20 maximal-effort eccentric repetitions with the nondominant arm only. On the morning of exercise and for 4 days thereafter, we measured serum malondialdehyde (MDA) and carotid-femoral pulse wave velocity (cfPWV) as indices of oxidative stress and arterial stiffness, respectively. On the third and fourth days after exercise, both MDA and cfPWV significantly increased in the placebo group. However, these elevations were significantly attenuated in the taurine group. The increase in MDA was associated with an increase in cfPWV from before exercise to 4 days after exercise (r = 0.597, p &lt; 0.05) in the placebo group, but not in the taurine group. Our results suggest that delayed increase in arterial stiffness after eccentric exercise was probably affected by the exercise-induced oxidative stress and was attenuated by the taurine supplementation.

    DOI

  • Increased physical activity has a greater effect than reduced energy intake on lifestyle modification-induced increases in testosterone

    Hiroshi Kumagai, Asako Zempo-Miyaki, Toru Yoshikawa, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   58 ( 1 ) 84 - 89  2016年01月  [査読有り]

     概要を見る

    Obesity has reached epidemic proportions worldwide. Obesity results in reduced serum testosterone levels, which causes many disorders in men. Lifestyle modifications (increased physical activity and calorie restriction) can increase serum testosterone levels. However, it is unknown whether increased physical activity or calorie restriction during lifestyle modifications has a greater effects on serum testosterone levels. Forty-one overweight and obese men completed a 12-week lifestyle modification program (aerobic exercise training and calorie restriction). We measured serum testosterone levels, the number of steps, and the total energy intake. We divided participants into two groups based on the median change In the number of steps (high or low physical activities) or that in calorie restriction (high or low calorie restrictions). After the program, serum testosterone levels were significantly increased. Serum testosterone levels in the high physical activity group were significantly higher than those in the low activity group. This effect was not observed between the groups based on calorie restriction levels. We found a significant positive correlation between the changes in serum testosterone levels and the number of steps. Our results suggested that an increase in physical activity greatly affected the increased serum testosterone levels in overweight and obese men during lifestyle modification.

    DOI

  • Effect of static squat exercise with whole body vibration on arterial stiffness in older women

    Maeda,Seiji

    Advances in Exercise and Sports Physiology   22   13 - 17  2016年  [査読有り]

  • タウリンと血管内皮機能

    Maeda,Seiji

    タウリンリサーチ   2 ( 1 ) 40 - 42  2016年  [査読有り]

     概要を見る

    本稿では、健常者における経口タウリン摂取が血管内皮機能に及ぼす効果を、安静時および運動時に分けて概説する。我々はまず、2週間の経口タウリン摂取(6g/day)は、健常者の血管内皮機能を僅かながら、有意に向上させることが初めて見出した。次に、運動誘発性血管内皮機能の低下に対するタウリン摂取の効果を検証したものの、2週間のタウリン摂取(6g/day)では高強度レジスタンス運動による血管内皮機能の低下を抑制できないことが明らかになった。本稿で示すこれらの結果は、少なくとも安静時においては、健常者においてもタウリン製剤、もしくはタウリンを多く含む魚介類や海藻類の摂取は血管内皮機能を良好に保つために有効であることを示していると考える。(著者抄録)

  • 肥満者における生活習慣改善が動脈スティフネスと炎症性因子に及ぼす影響

    熊谷 仁, 膳法 亜沙子, 吉川 徹, 妙圓園 香苗, 蘇 リナ, 西保 岳, 田中 喜代次, 前田 清司

    体力科学   64 ( 6 ) 666 - 666  2015年12月

  • Changes in arterial stiffness and nitric oxide production with Chlorella-derived multicomponent supplementation in middle-aged and older individuals.

    Otsuki T, Shimizu K, Maeda S

    Journal of clinical biochemistry and nutrition   57 ( 3 ) 228 - 232  2015年11月  [査読有り]  [国内誌]

    DOI PubMed

  • AGGRESSIVE Room2 運動と予防医療

    田村好史, 前田清司, 真田樹義, 宮地元彦

    予防医療AGGRESSIVE   2 ( 3 ) 33-42  2015年10月

  • Influence of aerobic exercise training on post-exercise responses of aortic pulse pressure and augmentation pressure in postmenopausal women

    Nobuhiko Akazawa, Song-Gyu Ra, Jun Sugawara, Seiji Maeda

    FRONTIERS IN PHYSIOLOGY   6  2015年10月  [査読有り]

     概要を見る

    Central arterial blood pressure (BP) is more predictive of future cardiovascular events than is brachial BP because it reflects the BP load imposed on the left ventricle with greater accuracy. However, little is known about the effects of exercise training on central hemodynamic response to acute exercise. The purpose of the present study was to determine the influence of an aerobic exercise regimen on the response of aortic BP after a single aerobic exercise in postmenopausal women. Nine healthy postmenopausal women (age: 61 + 2 years) participated in a 12-week aerobic exercise training regimen. Before and after the training, each subjects performed a single bout of cycling at ventilatory thresholds for 30 min. We evaluated the post exercise aortic BP response, which was estimated via the general transfer function from applanation tonometry. After the initial pre-training aerobic exercise session, aortic BP did not change significantly: however, aortic pulse pressure and augmentation pressure were significantly attenuated after the single aerobic exercise session following the 12 week training regimen. The present study demonstrated that a regular aerobic exercise training regimen induced the post-exercise reduction of aortic pulse pressure and augmentation pressure. Regular aerobic exercise training may enhance post-exercise reduction in aortic BP.

    DOI

  • Association between plasma sLOX-1 concentration and arterial stiffness in middle-aged and older individuals

    Takeshi Otsuki, Seiji Maeda, Jun Mukai, Makoto Ohki, Mamoru Nakanishi, Toshikazu Yoshikawa

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   57 ( 2 ) 151 - 155  2015年09月  [査読有り]

     概要を見る

    Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is implicated in vascular endothelial function. Vascular endothelial function is a potent regulator of arterial stiffness, an independent risk factor for cardiovascular disease. However, it is unknown whether LOX-1 is associated with arterial stiffness. Plasma concentrations of soluble LOX-1 (sLOX-1) and brachial-ankle pulse wave velocity (baPWV, an index of arterial stiffness) were measured in 143 individuals between 51 and 83 years of age. Plasma sLOX-1 concentration was correlated with baPWV (r = 0.288, p = 0.0005). In stepwise regression analysis, plasma sLOX-1 concentration was associated with baPWV, after adjusting for age; body mass index; blood pressure; heart rate; blood levels of cholesterol, triglycerides, glucose, hemoglobin A1c, and insulin; sex; and use of antihypertensives, lipid-lowering agents, and other medications (R-2 = 0.575, p&lt;0.0001). Multiple logistic regression demonstrated that plasma sLOX-1 concentration was independently associated with elevated baPWV (&gt;= 14.0 m/s; odds ratio, 1.01; 95% confidence interval, 1.00-1.03; p = 0.03). These results suggest that LOX-1 is associated with arterial stiffness.

    DOI

  • Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin

    Yoko Tanabe, Seiji Maeda, Nobuhiko Akazawa, Asako Zempo-Miyaki, Youngju Choi, Song-Gyu Ra, Atsushi Imaizumi, Yoshihiko Otsuka, Kazunori Nosaka

    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY   115 ( 9 ) 1949 - 1957  2015年09月  [査読有り]

     概要を見る

    Polyphenolic curcumin is known to have potent anti-inflammatory effects; thus the present study investigated the hypothesis that curcumin ingestion would attenuate muscle damage after eccentric exercise.
    Fourteen untrained young men (24 +/- A 1 years) performed 50 maximal isokinetic (120A degrees/s) eccentric contractions of the elbow flexors of one arm on an isokinetic dynamometer and the same exercise with the other arm 4 weeks later. They took 150 mg of curcumin (theracurmin) or placebo (starch) orally before and 12 h after each eccentric exercise bout in a randomised, crossover design. Maximal voluntary contraction (MVC) torque of the elbow flexors, range of motion of the elbow joint, upper-arm circumference, muscle soreness, serum creatine kinase (CK) activity, and plasma interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) concentration were measured before, immediately after, and 24, 48, 72 and 96 h after each eccentric exercise. Changes in these variables over time were compared between curcumin and placebo conditions by two-way repeated measures ANOVA.
    MVC torque decreased smaller and recovered faster (e.g., 4 days post-exercise: -31 +/- A 13 % vs. -15 +/- A 15 %), and peak serum CK activity was smaller (peak: 7684 +/- A 8959 IU/L vs. 3398 +/- A 3562 IU/L) for curcumin than placebo condition (P &lt; 0.05). However, no significant differences between conditions were evident for other variables, and no significant changes in IL-6 and TNF-alpha were evident after exercise.
    It is concluded that theracurmin ingestion attenuates some aspects of muscle damage such as MVC loss and CK activity increase.

    DOI

  • Impact of short-term training camp on arterial stiffness in endurance runners

    Tsubasa Tomoto, Jun Sugawara, Ai Hirasawa, Tomoko Imai, Seiji Maeda, Shigehiko Ogoh

    JOURNAL OF PHYSIOLOGICAL SCIENCES   65 ( 5 ) 445 - 449  2015年09月  [査読有り]

     概要を見る

    Lack of elasticity in the central artery causes an increase in left ventricular (LV) afterload. Although regular moderate-intensity endurance exercise improves cardiovascular function, including arterial destiffening, little is known about the effect of short-term vigorous exercise on cardiovascular function (i.e., the interaction between cardiac and arterial functions). We measured arterial stiffness [via pulse wave velocity from the heart to ankle (haPWV)] and LV contractility (via systolic interval time) before and after a 1-week training camp in a total of 33 regularly highly-trained collegiate endurance runners. They participated in three training sessions per day which mainly consisted of long-distance running and sprint training. The averaged running distance was a parts per thousand 44 % longer during the camp than the regular training program. After the camp, heart rate at rest and haPWV were significantly increased, whereas blood pressure remained unchanged. Although a ratio of pre-ejection period and LV ejection time (PEP/LVET, an index of blunted LV contractility) was unaltered, presumably due to the large variability of individual response, there was a significant correlation between changes in haPWV and PEP/LVET (r = 0.54, P &lt; 0.01). These results suggest that, in regularly highly-trained endurance athletes, arterial stiffness increases after a training camp characterized by greater training volume (vs. regular training), and that the individual response in arterial stiffness correlates with the corresponding changes in myocardial contractility.

    DOI PubMed

  • The influence of central arterial compliance on cerebrovascular hemodynamics: insights from endurance training intervention

    Tsubasa Tomoto, Jun Sugawara, Yoshie Nogami, Kazutaka Aonuma, Seiji Maeda

    JOURNAL OF APPLIED PHYSIOLOGY   119 ( 5 ) 445 - 451  2015年09月

     概要を見る

    Normally, central elastic arteries (e.g., aorta and common carotid artery) effectively buffer cardiac pulsation-induced flow/pressure fluctuations. With advancing age, arterial stiffening deteriorates this function and produces the greater cerebral hemodynamic pulsatility that impacts vulnerable brain tissue. It is well known that the buffering function of the central artery is improved by regular aerobic exercise, but the influence of endurance training on the pulsatile component of cerebral hemodynamics remains poorly understood. To characterize the functional role of the central artery at the heart-brain hemodynamic connection comprehensively, we assessed relations among the endurance training-induced changes in the left ventricle (LV), carotid arterial compliance, and cerebral hemodynamics. Thirteen collegiate tennis players (20 +/- 1 yr) underwent a 16-wk endurance training intervention designed for improving cardiovascular function. Expectedly, maximal oxygen uptake ((V) over dotO(2peak)), LV ejection velocity (via Doppler ultrasound), and the maximal rate of pressure increase of estimated aortic pressure waveform (via general transfer function) improved after the training intervention, whereas middle cerebral arterial (MCA) hemodynamics (via transcranial Doppler), such as mean and pulsatile flow velocities, remained unchanged. Carotid arterial compliance (via ultrasound and applanation tonometry) increased after the training intervention, and a larger increase in carotid arterial compliance was significantly associated with the greater attenuations of pulsatile MCA velocity (r = -0.621) normalized by mean MCA velocity. These results suggest that the training-induced improvement of carotid artery Windkessel function might offset the expected increase in the pulsatile component of cerebral perfusion induced by the enhanced LV systolic function.

    DOI

  • No influence of lower leg heating on central arterial pulse pressure in young men

    Keisei Kosaki, Jun Sugawara, Nobuhiko Akazawa, Koichiro Tanahashi, Hiroshi Kumagai, Ryuichi Ajisaka, Seiji Maeda

    JOURNAL OF PHYSIOLOGICAL SCIENCES   65 ( 4 ) 311 - 316  2015年07月  [査読有り]

     概要を見る

    Central arterial pulse pressure (PP), a strong predictor of cardiovascular disease, mainly consists of an incident wave generated by left ventricular ejection and a late-arriving reflected wave emanating from the lower body. We have tested the hypothesis that a reduction in leg vascular tone by heat treatment of the lower leg attenuates the central arterial PP. Pressure and wave properties of the peripheral and central arteries were measured in eight young men before and after heat treatment of the lower leg (temperature approx. 43 A degrees C) for 30 and 60 min, respectively. Following the lower leg heat trial, leg (femoral-ankle) pulse wave velocity (PWV) was significantly decreased, but aortic (carotid-femoral) PWV and parameters of wave reflection and carotid arterial PP did not change significantly. No significant changes were observed in these parameters in the control trial. These results suggest that the reduction in leg vascular tone induced by heat treatment of the lower leg may not affect wave reflection and central arterial PP in young men.

    DOI

  • Lifestyle modification increases serum testosterone level and decrease central blood pressure in overweight and obese men

    Hiroshi Kumagai, Asako Zempo-Miyaki, Toru Yoshikawa, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    ENDOCRINE JOURNAL   62 ( 5 ) 423 - 430  2015年05月  [査読有り]

     概要を見る

    Obesity has reached global epidemic proportions and is associated with multiple comorbidities, including cardiovascular disease. A novel predictor of cardiovascular disease is elevated central systolic blood pressure. In fact, lifestyle modifications have been shown to decrease the central systolic blood pressure in overweight and obese men. The mechanism underlying these changes has yet to be fully elucidated. Interestingly, testosterone has been found to have cardioprotective effects. Moreover, serum testosterone levels are lower in obese men than in normal weight men. However, it is still unclear whether testosterone participates in the decrease of central blood pressure in overweight and obese men following lifestyle modifications. So, the purpose of the present study was to investigate the effect of testosterone on central systolic blood pressure in overweight and obese men before and after the 12-week lifestyle modification program. Forty-four overweight and obese men completed a 12-week lifestyle modification program (aerobic exercise training and dietary modifications). For all participants, central systolic blood pressure and serum testosterone levels were measured before and after the program. After the program, central systolic blood pressure was significantly decreased while serum total testosterone levels were significantly increased in overweight and obese men. Moreover, we also found a significant negative relationship between the change in serum testosterone levels and that in central systolic blood pressure. The present study suggests that increased serum testosterone levels likely contribute to a decrease in central blood pressure in overweight and obese men.

  • Lifestyle Modification Decreases Arterial Stiffness in Overweight and Obese Men: Dietary Modification vs. Exercise Training

    Seiji Maeda, Asako Zempo-Miyaki, Hiroyuki Sasai, Takehiko Tsujimoto, Rina So, Kiyoji Tanaka

    INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM   25 ( 1 ) 69 - 77  2015年02月  [査読有り]

     概要を見る

    Obesity and increased arterial stiffness are independent risk factors for cardiovascular disease. Arterial stiffness is increased in obese individuals than in age-matched nonobese individuals. We demonstrated that dietary modification and exercise training are effective in reducing arterial stiffness in obese persons. However, the differences in the effect on arterial stiffness between dietary modification and exercise training are unknown. The purpose of the current study was to compare the effect of dietary modification and aerobic exercise training on arterial stiffness and endothelial function in overweight and obese persons. Forty-five overweight and obese men (48 +/- 1 year) completed either a dietary modification (well-balanced nutrient, 1680 kcal/day) or an exercise-training program (walking, 40-60 min/day, 3 days/week) for 12 weeks. Before and after the intervention, all participants underwent anthropometric measurements. Arterial stiffness was measured based on carotid arterial compliance, brachial-ankle pulse wave velocity (baPWV), and endothelial function was determined by circulating level of endothelin-1 (ET-1) and nitric oxide metabolite (nitrites/nitrate as metabolite: NOx). Body mass and waist circumference significantly decreased after both intervention programs. Weight loss was greater after dietary modification than after exercise training (-10.1 +/- 0.6 kg vs. -3.6 +/- 0.5 kg, p &lt; .01). Although arterial stiffness and the plasma levels of ET-1 and NOx were improved after dietary modification or exercise training, there were no differences in those improvements between the 2 types of interventions. Exercise training improves arterial function in obese men without as much weight loss as after dietary modification.

    DOI

  • Taurine Supplementation Reduces Eccentric Exercise-Induced Delayed Onset Muscle Soreness in Young Men

    Song-Gyu Ra, Nobuhiko Akazawa, Youngju Choi, Tomoko Matsubara, Satoshi Oikawa, Hiroshi Kumagai, Koichiro Tanahashi, Hajime Ohmori, Seiji Maeda

    TAURINE 9   803   765 - 772  2015年  [査読有り]

    DOI

  • Attenuated age-related increases in arterial stiffness in Japanese and American women

    Hirofumi Tanaka, Motohiko Miyachi, Haruka Murakami, Seiji Maeda, Jun Sugawara

    Journal of the American Geriatrics Society   63   1170 - 1174  2015年01月

     概要を見る

    © 2015, The American Geriatrics Society. Background The United States and Japan have similar standards of living, healthcare systems, and industrializations but exhibit markedly divergent life expectancies both at birth and at later ages (50 or 65 years old). Arterial stiffness has been widely regarded as a barometer of biological or physiological aging and could provide insight into the inter-country differences. Objectives To determine whether the increases in arterial stiffness across the adult age range are greater in U.S. than Japanese adults. Design Cross-sectional analyses. Setting Laboratory-based study. Participants Healthy, nonsmoking Japanese (n = 400) and U.S. (n = 400) adults without cardiovascular and other chronic diseases. Measurements Indices of arterial stiffness, including carotid-femoral (cfPWV) and brachial-ankle pulse wave velocity (baPWV) were measured, along with a variety of ancillary measures. The recruitment method, measurement technique, and protocol were standardized and identical between U.S. and Japanese facilities. Results cfPWV and baPWV increased progressively with advancing age in all subgroups (stratified according to sex and country). The rates of age-related increases in arterial stiffness were not different between U.S. and Japanese men, but age-associated increases in cfPWV were significantly greater in U.S. than Japanese women, widening the intercountry differences at older age ranges. Conclusion Japanese women had smaller increases in central arterial stiffness with advancing age than U.S. women.

    DOI PubMed

  • Aerobic Exercise Training Improves Vascular Endothelial Function with an Increase in Circulating Klotho Levels in Postmenopausal Women

    MATSUBARA, Tomoko, ZEMPO-MIYAKI, Asako, AKAZAWA, Nobuhiko, CHOI, Youngju, RA, Song-Gyu, TANAHASHI, Koichiro, KUMAGAI, Hiroshi, OIKAWA, Satoshi, YOSHIKAWA, Toru, MAEDA, Seiji

    Advances in exercise and sports physiology   20 ( 3 ) 61 - 66  2014年12月

     概要を見る

    Circulating Klotho is expected to have vascular protective effects, including the enhancement of nitric oxide (NO) production by endothelial cells. Aerobic exercise training increases circulating Klotho levels and improves endothelial function, which decreases with aging. However, it is unclear whether aerobic exercise training-induced improvement in endothelial function is related to elevation of circulating Klotho levels. In the present study, we investigated the effect of aerobic exercise training on the correlation between plasma Klotho levels and endothelial function in postmenopausal women. First, we studied the correlation between plasma Klotho levels and flow-mediated vasodilation (FMD) as an index of endothelial function. FMD correlated positively with plasma Klotho levels, but the baseline diameter did not correlate with plasma Klotho levels. Second, we examined the effects of aerobic exercise training on plasma Klotho levels and FMD. After aerobic exercise training, plasma Klotho levels and FMD increased significantly. Furthermore, there was a positive correlation between the changes in plasma Klotho levels and those in FMD. These results suggested that an increase in ci

  • Fish oil constituent eicosapentaenoic acid inhibits endothelin-induced cardiomyocyte hypertrophy via PPAR-α

    Maeda,Seiji

    Life Sciences   118 ( 2 ) 173 - 178  2014年11月  [査読有り]

    DOI

  • Metabolomics of salivary fatigue markers in soccer players after consecutive games

    Song-Gyu Ra, Seiji Maeda, Ryota Higashino, Tomoko Imai, Shumpei Miyakawa

    APPLIED PHYSIOLOGY NUTRITION AND METABOLISM   39 ( 10 ) 1120 - 1126  2014年10月

     概要を見る

    Strenuous and consecutive exercise leads to fatigue symptoms in athletes. Metabolomics is a comprehensive method to assess metabolites that involves the measurements of the overall metabolic signature of biological samples. Using metabolomic analysis, we investigated the identification of salivary fatigue markers in soccer players after 3 consecutive days of a game program. One hundred twenty-two male soccer players participated in 3 consecutive days of a game program. To detect fatigued athletes, we measured indices of traditional fatigue symptoms, i.e., heart rate, body mass and mood, before and after the program. We detected 37 fatigued players throughout the program. Before and after the program, the saliva in these players was analyzed using capillary electrophoresis and time-of-flight mass spectrometry (CE-TOFMS) and a multivariate statistical technique, principal component analysis, was used to process the data. CE-TOFMS was used to identify 144 metabolites in the saliva of fatigued players. A significant metabolomic difference was observed before and after 3 consecutive days of a soccer game program. Interestingly, metabolites were all increased after the program (P &lt; 0.001). The identified metabolites, including 3-methylhistidine, glucose 1- and 6-phosphate, taurine, and some amino acids, were involved in skeletal muscle catabolism, glucose metabolism, lipid metabolism, amino acid metabolism, and energy metabolism. Our work demonstrated some salivary metabolites were significantly increased in the fatigued players after consecutive days of short soccer matches. We propose that the detected salivary metabolites may be new fatigue markers in athletes.

    DOI

  • Metabolomics of salivary fatigue markers in soccer players after consecutive games

    Song-Gyu Ra, Seiji Maeda, Ryota Higashino, Tomoko Imai, Shumpei Miyakawa

    APPLIED PHYSIOLOGY NUTRITION AND METABOLISM   39 ( 10 ) 1120 - 1126  2014年10月  [査読有り]

     概要を見る

    Strenuous and consecutive exercise leads to fatigue symptoms in athletes. Metabolomics is a comprehensive method to assess metabolites that involves the measurements of the overall metabolic signature of biological samples. Using metabolomic analysis, we investigated the identification of salivary fatigue markers in soccer players after 3 consecutive days of a game program. One hundred twenty-two male soccer players participated in 3 consecutive days of a game program. To detect fatigued athletes, we measured indices of traditional fatigue symptoms, i.e., heart rate, body mass and mood, before and after the program. We detected 37 fatigued players throughout the program. Before and after the program, the saliva in these players was analyzed using capillary electrophoresis and time-of-flight mass spectrometry (CE-TOFMS) and a multivariate statistical technique, principal component analysis, was used to process the data. CE-TOFMS was used to identify 144 metabolites in the saliva of fatigued players. A significant metabolomic difference was observed before and after 3 consecutive days of a soccer game program. Interestingly, metabolites were all increased after the program (P &lt; 0.001). The identified metabolites, including 3-methylhistidine, glucose 1- and 6-phosphate, taurine, and some amino acids, were involved in skeletal muscle catabolism, glucose metabolism, lipid metabolism, amino acid metabolism, and energy metabolism. Our work demonstrated some salivary metabolites were significantly increased in the fatigued players after consecutive days of short soccer matches. We propose that the detected salivary metabolites may be new fatigue markers in athletes.

    DOI

  • Dehydroepiandrosterone Administration Increased Trabecular Mass and Dihydrotestosterone Levels in the Cancellous Region of the Tibia in Young Female Rats

    J. Park, K. Aizawa, T. Akimoto, M. Iemitsu, U. Agata, S. Maeda, K. Lim, N. Omi

    HORMONE AND METABOLIC RESEARCH   46 ( 9 ) 651 - 655  2014年08月  [査読有り]

     概要を見る

    The aim of the present study was to determine whether dehydroepiandrosterone (DHEA) administration affects bone mass and local sex hormone levels in the cancellous region of young female rats. Eleven female rats (6 weeks old) were randomly divided into 2 groups: control rats (CON, n = 5) and rats treated with DHEA (DHEA, n = 6). DHEA dissolved in sesame oil was administered to the DHEA group intraperitoneally at 20 mg DHEA/kg body weight, and the CON group was treated with vehicle only (sesame oil, 0.5 ml). The rats were treated with DHEA or vehicle for 3 consecutive days, followed by 1 day of no treatment. The experimental period was 8 weeks. According to dual-energy X-ray absorptiometry and high-resolution microcomputed tomography data, the DHEA group exhibited increased trabecular bone mineral density (BMD), bone volume, and tibial thickness compared to the findings in the CON group, whereas no effect was observed on cortical BMD or morphometry. The concentrations of free testosterone and estradiol in the cancellous region of the tibia did not differ between the 2 groups, but the DHT concentration was significantly higher in the DHEA group than in the CON group. These findings suggest that an increase in local DHT levels may stimulate an increase in trabecular bone mass during growth phases in female rats.

    DOI

  • Effects of selective endothelin (ET)-A receptor antagonist versus dual ET-A/B receptor antagonist on hearts of streptozotocin-treated diabetic rats

    Yumi Miyauchi, Subrina Jesmin, Satoshi Sakai, Junko Kamiyama, Nobutake Shimojo, Arifur Rahman, Majedul Islam, Sohel Zaedi, Seiji Maeda, Hidekazu Maruyama, Taro Mizutani, Satoshi Homma, Kazutaka Aonuma, Takashi Miyauchi

    LIFE SCIENCES   111 ( 1-2 ) 6 - 11  2014年08月  [査読有り]

     概要を見る

    Aims: The aim was to study the differences in the effectiveness of two types of endothelin (ET) receptor antagonists (selective ET-A or dual ET-A/B antagonists) on the hearts of streptozotocin (STZ)-induced diabetic rats (type I diabetes) at functional and biochemical/molecular levels.
    Main methods: Citrate saline (vehicle) or STZ was injected into rats. The ET-A/B dual receptor antagonist (SB209670, 1 mg/kg/day) and the ET-A receptor antagonist (TA-0201, 1 mg/kg/day) were then administered to these rats. One week after injection, the animals were separated into those receiving SB209670, TA-0201 or vehicle by 4-week osmotic mini-pump.
    Key findings: The VEGF level and percent fractional shortening in the diabetic heart were significantly decreased compared to the non-diabetic heart, whereas SB209670 and TA-0201 treatments greatly and comparably prevented this decrease. SB209670 treatment was more effective in reversing decreased expressions of KDR and phosphorylated AKT, downstream of VEGF angiogenic signaling, than TA-0201 treatment. The eNOS levels in hearts were significantly higher in diabetic rats than in healthy rats, and this increase was significantly reduced by TA-0210 but not by SB209670 treatment.
    Significance: Improvement of KDR mRNA and pAKT levels by SB209670 but not TA-0201 suggests that dual ET-A/-B blockade may be effective in improving intracellular systems of these components in the diabetic rat heart. However, the present study also showed that TA-0201 or SB209670 improved percent fractional shortening and VEGF levels of the diabetic hearts to a similar extent, suggesting that ET-A blockade and dual ET-A/-B blockade are similarly effective in improving cardiac dysfunction in the diabetic rats. (C) 2014 Elsevier Inc. All rights reserved.

    DOI

  • Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women

    Koichiro Tanahashi, Nobuhiko Akazawa, Asako Miyaki, Youngju Choi, Song-Gyu Ra, Tomoko Matsubara, Hiroshi Kumagai, Satoshi Oikawa, Takashi Miyauchi, Seiji Maeda

    LIFE SCIENCES   108 ( 1 ) 30 - 33  2014年07月  [査読有り]

     概要を見る

    Aims: Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aerobic exercise has a beneficial effect on cardiovascular disease. However, the relationship between ADMA and aerobic fitness is unknown. The aim of this study was to determine whether plasma ADMA concentrations correlate with aerobic fitness levels in postmenopausal women.
    Main methods: Thirty healthy postmenopausal women aged 50-76 years participated in this study. We measured plasma concentrations of ADMA and oxygen consumption at the ventilatory threshold (VO2VT) as an index of aerobic fitness. Subjects were divided into the low aerobic fitness (Low fitness) and high aerobic fitness (High fitness) groups, and the dividing line was set at the median VO2VT value.
    Key findings: VO2VT was significantly higher in the High fitness group than in the Low fitness group (P &lt; 0.01). The plasma ADMA concentrations in the High fitness group were significantly lower than those in the Low fitness group (P &lt; 0.05). There was a negative correlation between plasma ADMA concentrations and VO2VT (r = -0.532, P &lt; 0.01).
    Significance: We found that plasma ADMA concentrations were associated with aerobic fitness in postmenopausal women. The results of this study suggest that habitual aerobic exercise may decrease plasma ADMA concentrations. (C) 2014 Elsevier Inc. All rights reserved.

    DOI

  • Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women

    Koichiro Tanahashi, Nobuhiko Akazawa, Asako Miyaki, Youngju Choi, Song-Gyu Ra, Tomoko Matsubara, Hiroshi Kumagai, Satoshi Oikawa, Takashi Miyauchi, Seiji Maeda

    LIFE SCIENCES   108 ( 1 ) 30 - 33  2014年07月  [査読有り]

     概要を見る

    Aims: Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aerobic exercise has a beneficial effect on cardiovascular disease. However, the relationship between ADMA and aerobic fitness is unknown. The aim of this study was to determine whether plasma ADMA concentrations correlate with aerobic fitness levels in postmenopausal women.
    Main methods: Thirty healthy postmenopausal women aged 50-76 years participated in this study. We measured plasma concentrations of ADMA and oxygen consumption at the ventilatory threshold (VO2VT) as an index of aerobic fitness. Subjects were divided into the low aerobic fitness (Low fitness) and high aerobic fitness (High fitness) groups, and the dividing line was set at the median VO2VT value.
    Key findings: VO2VT was significantly higher in the High fitness group than in the Low fitness group (P &lt; 0.01). The plasma ADMA concentrations in the High fitness group were significantly lower than those in the Low fitness group (P &lt; 0.05). There was a negative correlation between plasma ADMA concentrations and VO2VT (r = -0.532, P &lt; 0.01).
    Significance: We found that plasma ADMA concentrations were associated with aerobic fitness in postmenopausal women. The results of this study suggest that habitual aerobic exercise may decrease plasma ADMA concentrations. (C) 2014 Elsevier Inc. All rights reserved.

    DOI

  • Response to “Aerobic Exercise and Endothelial Function in Pre- and Post-Menopausal Women”

    Maeda,Seiji

    American Journal of Hypertension   27 ( 7 ) 990 - 990  2014年07月  [査読有り]

    DOI

  • クロレラ由来の総合栄養サプリメントは加齢および肥満に伴う唾液分泌量の低下を軽減する

    大槻 毅, 清水 和弘, 荒川 ゆかり, 前田 清司

    日本抗加齢医学会総会プログラム・抄録集   14回   334 - 334  2014年06月

  • Response to "Arterial Stiffness and Pentraxin 3 Levels in Obese Patients"

    Asako Miyaki, Seiji Maeda

    AMERICAN JOURNAL OF HYPERTENSION   27 ( 6 ) 882 - 882  2014年06月  [査読有り]

    DOI

  • Acute Aerobic Exercise Increases Serum Estradiol Concentrations In Young Healthy Men

    Satoshi Oikawa, Yuriko Tochigi, Nobuhiko Akazawa, Koichiro Tanahashi, Seiji Maeda

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   46 ( 5 ) 405 - 406  2014年05月

  • Aerobic Exercise Training Decreases Plasma Asymmetric Dimethylarginine Concentrations With Increase in Arterial Compliance in Postmenopausal Women

    Koichiro Tanahashi, Nobuhiko Akazawa, Asako Miyaki, Youngju Choi, Song-Gyu Ra, Tomoko Matsubara, Hiroshi Kumagai, Satoshi Oikawa, Seiji Maeda

    AMERICAN JOURNAL OF HYPERTENSION   27 ( 3 ) 415 - 421  2014年03月  [査読有り]

     概要を見る

    Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, increase with advancing age and menopausal status. ADMA plays a role in endothelial dysfunction and increasing arterial stiffness. Regular aerobic exercise has a positive effect on arterial function (i.e., arterial compliance). This study investigated the effects of aerobic exercise training on plasma ADMA concentrations and arterial compliance in postmenopausal women.
    Thirty postmenopausal women were divided into 2 groups: an exercise group (n 20) and a control group (n 10). Subjects in the exercise group completed 12 weeks of aerobic exercise training (65%80% of maximal heart rate, 4060min/day, 36 days/week). Before and after each intervention, plasma ADMA concentrations and carotid arterial compliance were measured in all participants.
    The baseline plasma ADMA concentrations, carotid arterial compliance, and most other key dependent variables did not differ between the 2 groups. In the exercise group, carotid arterial compliance significantly increased after exercise intervention (P &lt; 0.01), and plasma ADMA concentrations significantly decreased (P &lt; 0.05). In addition, changes in carotid arterial compliance after the exercise intervention were inversely correlated with changes in plasma ADMA concentrations (r 0.367; P &lt; 0.05).
    We demonstrated that aerobic exercise training significantly decreased plasma ADMA concentrations with increase in carotid arterial compliance in postmenopausal women. These results suggest that reduction in ADMA may play an important role in the aerobic exercise traininginduced increase in arterial compliance.

    DOI

  • Pentraxin 3 Production in the Adipose Tissue and the Skeletal Muscle in Diabetic-Obese Mice

    Asako Miyaki, Youngju Choi, Seiji Maeda

    AMERICAN JOURNAL OF THE MEDICAL SCIENCES   347 ( 3 ) 228 - 233  2014年03月  [査読有り]

     概要を見る

    Inflammation has been shown to promote obesity-induced insulin resistance. Although pentraxin (PTX) 3 is known as an anti-inflammatory factor, the effect of PTX3 on insulin sensitivity has not yet been elucidated. The aim of this study is to investigate a part of the role of PTX3 on insulin sensitivity. The authors studied the PTX3 and glucose transport protein expression levels in epididymal adipose tissue and soleus muscles of male diabetic-obese [Tsumura Suzuki obese-diabetic (TSOD)] and lean control mice. The levels of PTX3 in both skeletal muscle and adipose tissue were significantly lower in TSOD mice than in controls, and there was a significant positive correlation between them. They observed a significant positive correlation between PTX3 and glucose transport protein 4 levels in skeletal muscle. This study suggests that PTX3 may play a part of role as promoting insulin sensitivity of skeletal muscle in TSOD mice.

    DOI

  • Response to Other Factors Ought to Be Kept in Mind When Analyzing Plasma Asymmetric Dimethylarginine Levels

    Koichiro Tanahashi, Nobuhiko Akazawa, Seiji Maeda

    AMERICAN JOURNAL OF HYPERTENSION   27 ( 3 ) 501 - 501  2014年03月  [査読有り]

    DOI

  • Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women

    Tomoko Matsubara, Asako Miyaki, Nobuhiko Akazawa, Youngju Choi, Song-Gyu Ra, Koichiro Tanahashi, Hiroshi Kumagai, Satoshi Oikawa, Seiji Maeda

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   306 ( 3 ) H348 - H355  2014年02月  [査読有り]

     概要を見る

    The Klotho gene is a suppressor of the aging phenomena, and the secretion as well as the circulation of Klotho proteins decrease with aging. Although habitual exercise has antiaging effects (e. g., a decrease in arterial stiffness), the relationship between Klotho and habitual exercise remains unclear. In the present study, we investigated the effect of habitual exercise on Klotho, with a particular focus on arterial stiffness. First, we examined the correlation between plasma Klotho concentration and arterial stiffness (carotid artery compliance and beta-stiffness index) or aerobic exercise capacity [oxygen uptake at ventilatory threshold (VT)] in 69 healthy, postmenopausal women (50-76 years old) by conducting a cross-sectional study. Second, we tested the effects of aerobic exercise training on plasma Klotho concentrations and arterial stiffness. A total of 19 healthy, postmenopausal women (50-76 years old) were divided into two groups: control group and exercise group. The exercise group completed 12 wk of moderate aerobic exercise training. In the cross-sectional study, plasma Klotho concentrations positively correlated with carotid artery compliance and VT and negatively correlated with the beta-stiffness index. In the interventional study, aerobic exercise training increased plasma Klotho concentrations and carotid artery compliance and decreased the beta-stiffness index. Moreover, the changes in plasma Klotho concentration and arterial stiffness were found to be correlated. These results suggest a possible role for secreted Klotho in the exercise-induced modulation of arterial stiffness.

    DOI

  • The effects of dietary modification, aerobic exercise training, and combined dietary modification and aerobic exercise training on central and peripheral arterial stiffness in obese men

    Asako Zempo-Miyaki, Rina So, Hiroshi Kumagai, Kiyoji Tanaka, Nobutake Shimojo, Seiji Maeda

    Japanese Journal of Physical Fitness and Sports Medicine   63 ( 3 ) 333 - 341  2014年  [査読有り]

     概要を見る

    Obesity and increasing of arterial stiffness are known as independent risk factors for cardiovascular disease. Previously, we demonstrated that dietary modification or aerobic exercise training can decrease arterial stiffness in obese individuals. However, it has not been compared the effect of dietary modification and/or aerobic exercise training on arterial stiffness in obese men. We compared the effect of three patterns of lifestyle modification (i.e., dietary modification, aerobic exercise training or combined them) on arterial stiffness in obese men. Fifty-three obese men completed the 12-week lifestyle modification program, dietary modification (D), aerobic exercise training (E) or combined D and E (DE). Before and after the program, all participants were measured central, peripheral, and systemic arterial stiffness (measured by carotid-femoral pulse wave velocity [cfPWV], femoral-ankle PWV [faPWV] and brachial-ankle PWV [baPWV]). We demonstrated that the degree of decrease in BMI was the greatest after DE, and that was greater after D than E. The level of decrease in baPWV after DE was the greatest among three interventions. On the other hand, the level of decrease in baPWV in D group was similar to E group. These results suggested that systemic arterial stiffness may be decreased by different mechanisms between D and E groups. We demonstrated that dietary modification decreased central and systemic arterial stiffness, and aerobic exercise training decreased central, systemic, and peripheral arterial stiffness in obese individuals. We also showed an additional effect of decreasing systemic arterial stiffness by combining dietary modification and aerobic exercise training in obese individuals.

    DOI

  • Aerobic exercise training improves vascular endothelial function with an increase in circulating Klotho levels in postmenopausal women

    Maeda,Seiji

    Advances in Exercise and Sports Physiology   20 ( 3 ) 61 - 66  2014年  [査読有り]

     概要を見る

    Circulating Klotho is expected to have vascular protective effects, including the enhancement of nitric oxide (NO) production by endothelial cells. Aerobic exercise training increases circulating Klotho levels and improves endothelial function, which decreases with aging. However, it is unclear whether aerobic exercise training-induced improvement in endothelial function is related to elevation of circulating Klotho levels. In the present study, we investigated the effect of aerobic exercise training on the correlation between plasma Klotho levels and endothelial function in postmenopausal women. First, we studied the correlation between plasma Klotho levels and flow-mediated vasodilation (FMD) as an index of endothelial function. FMD correlated positively with plasma Klotho levels, but the baseline diameter did not correlate with plasma Klotho levels. Second, we examined the effects of aerobic exercise training on plasma Klotho levels and FMD. After aerobic exercise training, plasma Klotho levels and FMD increased significantly. Furthermore, there was a positive correlation between the changes in plasma Klotho levels and those in FMD. These results suggested that an increase in ci

  • 男子大学サッカー選手における試合合宿前後の唾液中タウリン濃度の変動

    羅, 成圭, 前田, 清司, 今井, 智子, 宮川, 俊平

    体力科学   63 ( 4 ) 409 - 414  2014年

     概要を見る

    Strenuous and consecutive exercise results in fatigue symptoms accompanied decrease in salivary secretory immunoglobulin A (sIgA) in athletes. On the other hand, it has been reported that plasma taurine concentration was increased after the high intensity exercise. However, change in salivary taurine concentration after strenuous and consecutive exercise is unknown. The purpose of this study was to investigate the relationship between fatigue symptoms and changes in salivary taurine concentration in collegiate male soccer players. Thirty seven collegiate male soccer players participated in three consecutive days of match program. To detect of fatigued players, we measured awakening heart rate and body weight. As the results of these two measurements, we divided subjects to two groups (non-fatigue group, n=15; fatigue group, n=22). We also measured salivary sIgA and taurine concentrations before and after program. Before the program, there were no significant differences in any parameters between two groups. Salivary flow rate and sIgA secretion rate were significantly decreased after the program in the fatigue group. Furthermore, salivary taurine concentration was significantly inc

    DOI

  • Lack of changes in carotid artery compliance with systemic nitric oxide synthase inhibition

    J. Sugawara, Y. Saito, S. Maeda, M. Yoshizawa, H. Komine, M. Nakamura, R. Ajisaka, H. Tanaka

    Journal of Human Hypertension   28 ( 8 ) 494 - 499  2014年  [査読有り]

     概要を見る

    Proximal large elastic arteries (ascending aorta and carotid artery) have an important role in buffering the pulsatile pressure generated from the left ventricle, which forwards continuous peripheral blood flow and protects the brain microcirculation from end-organ damage. Although compliance of distal conduit arteries (extremities' arteries) is attenuated by the nitric oxide synthase (NOS) inhibition, it is yet unknown whether compliance of proximal elastic arteries changes by the systemic NOS inhibition. To address this question, we measured central artery compliance in 17 young adults (26±1 years) who underwent intravenous infusions of N G -monomethyl-L-arginine (L-NMMA) or saline (placebo) on separate days. Following the systemic NOS inhibition, the mean arterial pressure (MAP), total peripheral resistance and aortic augmentation index were significantly increased. However, carotid artery compliance was not affected significantly (from 0.10±0.01 to 0.11±0.01 mm 2 per mmHg) and the β-stiffness index (an index of arterial compliance adjusted for the distending pressure) tended to decrease (from 6.63±0.35 to 6.06±0.42 a.u., P=0.07). These parameters were not altered with saline infusion. Changes in the β-stiffness index tended to correlate negatively with the corresponding changes in MAP (r=-0.31, P=0.07). These results suggest that carotid artery compliance remains unchanged during the systemic NOS inhibition in spite of systemic vasoconstriction. © 2014 Macmillan Publishers Limited.

    DOI PubMed

  • Lifestyle modification-induced increase in serum testosterone and SHBG decreases arterial stiffness in overweight and obese men

    Hiroshi Kumagai, Asako Miyaki, Ryota Higashino, Nobuhiko Akazawa, Youngju Choi, Song-Gyu Ra, Miki Eto, Kiyoji Tanaka, Ryuichi Ajisaka, Seiji Maeda

    Artery Research   8 ( 3 ) 80 - 80  2014年  [査読有り]

    DOI

  • 若年男性における血漿タウリン濃度と血管内皮機能に関する横断研究

    Maeda,Seiji

    健康支援   16   15 - 22  2014年  [査読有り]

  • 肥満男性における食事改善、有酸素性運動、食事改善と有酸素性運動の併用が中心および末梢動脈スティフネスに与える影響

    Maeda,Seiji

    体力科学   63   333 - 341  2014年  [査読有り]

  • 男子大学サッカー選手における試合合宿前後の唾液中タウリン濃度の変動

    Maeda,Seiji

    体力科学   63   409 - 414  2014年  [査読有り]

  • Blood pressure regulation II: what happens when one system must serve two masters-oxygen delivery and pressure regulation?

    Maeda,Seiji

    European Journal of Applied Physiology   803   765 - 772  2014年  [査読有り]

  • 循環器系と運動

    Maeda,Seiji

    健康づくり   433   12 - 15  2014年  [査読有り]

  • 運動と動脈硬化度 —クルクミンの可能性を探る—

    Maeda,Seiji

    FOOD STYLE 21   18   51 - 53  2014年  [査読有り]

  • 英文原著論文紹介:肥満男性における生活習慣改善が中心血圧に及ぼす影響

    Maeda,Seiji

    Arterial Stiffness   20   64 - 65  2014年

  • 肥満男性の中心および末梢動脈の硬化度に対する有酸素運動と食事調節の効果(Effects of aerobic exercise and dietary modification on central and peripheral arterial stiffness in obese men)

    Zempo-Miyaki Asako, Kumagai Hiroshi, So Rina, Tanaka Kiyoji, Shimojo Nobutake, Maeda Seiji

    Advances in Exercise and Sports Physiology   19 ( 4 ) 112 - 112  2013年12月

  • 肥満男性の血清テストステロン濃度と動脈コンプライアンスに対する減量の効果(The effect of weight reduction on serum testosterone level and arterial compliance in obese men)

    Kumagai Hiroshi, Zempo-Miyaki Asako, Ra Song-Gyu, Tsujimoto Takehiko, Tanaka Kiyoji, Maeda Seiji

    Advances in Exercise and Sports Physiology   19 ( 4 ) 127 - 127  2013年12月

  • Effects of lifestyle modification on central blood pressure in overweight and obese men.

    Higashino R, Miyaki A, Kumagai H, Choi Y, Akazawa N, Ra SG, Tanabe Y, Eto M, So R, Tanaka K, Ajisaka R, Maeda S

    Blood pressure monitoring   18 ( 6 ) 311 - 315  2013年12月  [査読有り]  [国際誌]

    DOI PubMed

  • Combined effect of branched-chain amino acids and taurine supplementation on delayed onset muscle soreness and muscle damage in high-intensity eccentric exercise

    Song-Gyu Ra, Teruo Miyazaki, Keisuke Ishikura, Hisashi Nagayama, Shoichi Komine, Yoshio Nakata, Seiji Maeda, Yasushi Matsuzaki, Hajime Ohmori

    Journal of the International Society of Sports Nutrition   10 ( 1 ) 51  2013年11月  [査読有り]

     概要を見る

    Background: Previous studies have evaluated the effectiveness of branched-chain amino acid (BCAA) supplementation for preventing delayed onset muscle soreness (DOMS) and muscle damage induced by eccentric exercise, their findings have been inconclusive. Since taurine has anti-inflammatory and anti-oxidative effects, the present study investigated the combined effect of BCAA and taurine on DOMS and muscle damage.Methods: Thirty-six untrained male subjects (22.5 ± 3.8 years) were assigned to four groups (placebo + placebo [placebo], BCAA + placebo, placebo + taurine, and BCAA + taurine [combined]) and given a combination of 3.2 g BCAA (or placebo) and 2.0 g taurine (or placebo), three times a day, for two weeks prior to and three days after eccentric elbow flexor exercises. DOMS and muscle damage in the biceps brachii were subjectively and objectively evaluated using the visual analogue scale (VAS), upper arm circumference (CIR), and blood parameters (creatine kinase, lactate dehydrogenase [LDH], aldolase, and 8-hydroxydeoxyguanosine [8-OHdG]).Results: In the combined group, VAS and 8-OHdG two days after exercise, CIR two and three days after exercise and LDH from one to three days after exercise were significantly lower than the placebo group. The area under the curve from before exercise to four days later for CIR, LDH, and aldolase was also significantly lower in the combined group than in the placebo group.Conclusion: A combination of 3.2 g BCAA and 2.0 g taurine, three times a day, for two weeks prior to and three days after exercise may be a useful nutritional strategy for attenuating exercise-induced DOMS and muscle damage. © 2013 Ra et al.
    licensee BioMed Central Ltd.

    DOI

  • Lifestyle modification decreases arterial stiffness and plasma asymmetric dimethylarginine level in overweight and obese men

    Maeda, Seiji, Miyaki, Asako, Kumagai, Hiroshi, Eto, Miki, So, Rina, Tanaka, Kiyoji, Ajisaka, Ryuichi

    CORONARY ARTERY DISEASE   24 ( 7 ) 583 - 588  2013年11月  [国際誌]

    DOI PubMed

  • Association of plasma pentraxin 3 with arterial stiffness in overweight and obese individuals

    Asako Miyaki, Seiji Maeda, Youngju Choi, Nobuhiko Akazawa, Miki Eto, Kiyoji Tanaka, Ryuichi Ajisaka

    American Journal of Hypertension   26 ( 10 ) 1250 - 1255  2013年10月  [査読有り]

     概要を見る

    BACKGROUNDObesity and increased arterial stiffness are independent risk factors for cardiovascular disease. The degree of arterial stiffness in obese individuals is greater than that in normal-weight subjects. Pentraxin 3 (PTX3) is mainly produced by vascular tissues and exerts a cardioprotective effect. However, the relationship between PTX3 and arterial stiffness in obese individuals has not yet been clarified. In this study, we examined the relationships between obesity, arterial stiffness, and PTX3 levels in 282 subjects.METHODSAll participants were classified as normal weight, overweight, or obese on the basis of their body mass index. We measured the brachial-ankle pulse wave velocity (baPWV
    an index of arterial stiffness) and plasma PTX3 concentrations in all subjects. Additionally, the carotid-femoral PWV (cfPWV) was measured in 173 subjects.RESULTSWe found that baPWV and cfPWV in overweight and obese subjects were significantly higher than those in normal-weight subjects. Plasma PTX3 concentrations in normal-weight subjects were significantly higher than those in overweight and obese subjects. Moreover, PTX3 had a significant negative correlation with baPWV. However, stepwise multivariable linear regression analysis did not indicate any associations between these parameters.CONCLUSIONSArterial stiffness is increased in overweight and obese individuals. The increase in arterial stiffness may, at least in part, be associated with an obesity-related reduction in plasma PTX3 concentrations. © American Journal of Hypertension, Ltd 2013. All rights reserved.

    DOI PubMed

  • 中高齢肥満男性における生活習慣の改善が血中PTX3濃度に与える影響

    前田,清司

    健康医科学    2013年03月  [査読有り]

  • 高強度ウエイトトレーニング後の収縮時血圧と血漿シトルリンおよびオルニチン濃度の関連性(The relationship between systolic blood pressure and plasma citrulline and ornithine concentrations after high intensity resistance exercise)

    Ra Song-Gyu, Choi Youngju, Miyaki Asako, Akazawa Nobuhiko, Ajisaka Ryuichi, Maeda Seiji

    Advances in Exercise and Sports Physiology   18 ( 4 ) 86 - 86  2013年02月

  • 閉経後女性の有酸素運動能は脳血流速度に関連しているか(Is aerobic exercise capacity related to cerebral blood flow velocity in postmenopausal women?)

    Akazawa Nobuhiko, Choi Youngju, Miyaki Asako, Ajisaka Ryuichi, Maeda Seiji

    Advances in Exercise and Sports Physiology   18 ( 4 ) 95 - 95  2013年02月

  • 成人肥満男性の血清性ホルモン濃度に及ぼす耐久運動トレーニングの影響(Effect of endurance exercise training on serum sex-hormoneslevels in obese adult men)

    Ajisaka Ryuichi, Naruto Takehiro, Choi Youngju, Miyaki Asako, Akazawa Nobuhiko, Maeda Seiji, Tanaka Kiyoji

    Advances in Exercise and Sports Physiology   18 ( 4 ) 106 - 106  2013年02月

  • Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women

    Maeda,Seiji

    Artery Research    2013年01月  [査読有り]

  • 運動習慣と動脈老化

    前田,清司

    医学のあゆみ    2013年01月

  • Additional Effects of Taurine on the Benefits of BCAA Intake for the Delayed-Onset Muscle Soreness and Muscle Damage Induced by High-Intensity Eccentric Exercise

    Song-Gyu Ra, Teruo Miyazaki, Keisuke Ishikura, Hisashi Nagayama, Takafumi Suzuki, Seiji Maeda, Masaharu Ito, Yasushi Matsuzaki, Hajime Ohmori

    TAURINE 8, VOL 2: NUTRITION AND METABOLISM, PROTECTIVE ROLE, AND ROLE IN REPRODUCTION, DEVELOPMENT, AND DIFFERENTIATION   776   179 - 187  2013年

     概要を見る

    Taurine (TAU) has a lot of the biological, physiological, and pharmocological functions including anti-inflammatory and anti-oxidative stress. Although previous studies have appreciated the effectiveness of branched-chain amino acids (BCAA) on the delayed-onset muscle soreness (DOMS), consistent finding has not still convinced. The aim of this study was to examine the additional effect of TAU with BCAA on the DOMS and muscle damages after eccentric exercise. Thirty-six untrained male volunteers were equally divided into four groups, and ingested a combination with 2.0 g TAU (or placebo) and 3.2 g BCAA (or placebo), thrice a day, 2 weeks prior to and 4 days after elbow flexion eccentric exercise. Following the period after eccentric exercise, the physiological and blood biochemical markers for DOMS and muscle damage showed improvement in the combination of TAU and BCAA supplementation rather than in the single or placebo supplementations. In conclusion, additional supplement of TAU with BCAA would be a useful way to attenuate DOMS and muscle damages induced by high-intensity exercise.

    DOI

  • Habitual aerobic exercise increases plasma pentraxin 3 levels in middle-aged and elderly women

    Asako Miyaki, Seiji Maeda, Youngju Choi, Nobuhiko Akazawa, Yoko Tanabe, Ryuichi Ajisaka

    APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME   37 ( 5 ) 907 - 911  2012年10月  [査読有り]

     概要を見る

    Chronic inflammation that occurs with aging is one of the risk factors for cardiovascular disease. Regular exercise may prevent cardiovascular morbidity by decreasing chronic systematic inflammation. Additionally, excess inflammation can be reduced by the anti-inflammatory protein pentraxin 3 (PTX3). Thus, both habitual exercise and PTX3 have an anti-inflammatory effect. However, it is unclear whether regular exercise leads to increased plasma PTX3 concentration. In the present study, we investigated the effects of regular aerobic exercise on plasma PTX3 concentration in middle-aged and elderly women. Twenty-two postmenopausal women (60 +/- 6 years) were randomly divided evenly into 2 groups (i.e., exercise intervention and control). Subjects in the exercise group completed 2 months of regular aerobic exercise training (walking and cycling, 30-45 min, 3-5 days.week(-1)). Before and after the intervention, we evaluated plasma PTX3 concentration, peak oxygen uptake, blood chemistry, and arterial distensibility (carotid arterial compliance and beta-stiffness) in all participants. There were no significant differences in baseline parameters between the 2 groups. Plasma PTX3 concentration was significantly increased in the exercise group after the intervention (p &lt; 0.05). High-density lipoprotein cholesterol, peak oxygen uptake, and arterial compliance were also significantly increased (p &lt; 0.05), while beta-stiffness was markedly decreased (p &lt; 0.01) after the intervention. On the other hand, there was no change in the parameters tested in the control group. This study demonstrates that regular aerobic exercise increases plasma PTX3 concentration with improvement of high-density lipoprotein cholesterol, peak oxygen uptake, and arterial distensibility in postmenopausal women.

    DOI

  • Curcumin ingestion and aerobic exercise training improve vascular endothelial function in postmenopausal women

    Maeda,Seiji

    Nutrition Research    2012年09月  [査読有り]

  • Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease

    Maeda,Seiji

    Life Sciences    2012年08月  [査読有り]

  • Effect of Endurance Exercise Training and Curcumin Intake on Central Arterial Hemodynamics in Postmenopausal Women: Pilot Study

    Jun Sugawara, Nobuhiko Akazawa, Asako Miyaki, Youngju Choi, Yoko Tanabe, Tomoko Imai, Seiji Maeda

    AMERICAN JOURNAL OF HYPERTENSION   25 ( 6 ) 651 - 656  2012年06月  [査読有り]

     概要を見る

    BACKGROUND
    Lifestyle modification (i.e., regular physical activity and diet) is effective in preventing the age-related increase in cardiovascular disease risks. Potential therapeutic effects of curcumin (diferuloylmethane) have been confirmed on various diseases, including cancer and Alzheimer's disease, but the effects of curcumin have not been tested on central arterial hemodynamics. The aim of this pilot study was to test the hypothesis that the regular endurance exercise combined with daily curcumin ingestion lowers the age-related increase in left ventricular (LV) afterload to a greater extent than monotherapy with either intervention alone in postmenopausal women using a randomized, double-blind, placebo-controlled, parallel manner.
    METHODS
    Forty-five women were randomly assigned to four interventions: "placebo ingestion" (n = 11), "curcumin ingestion" (n = 11), "exercise training with placebo ingestion" (n = 11), or "exercise training with curcumin ingestion" (n = 12). Curcumin or placebo pills (150 mg/day) were administered for 8 weeks. Aortic blood pressure (BP) and augmentation index (AIx), an index of LV afterload, were evaluated by pulse wave analysis from tonometrically measured radial arterial pressure waveforms.
    RESULTS
    There were no significant differences in baseline hemodynamic variables among four groups. After the interventions, brachial systolic BP (SBP) significantly decreased in both exercise-trained groups (P &lt; 0.05 for both), whereas aortic SBP significantly decreased only in the combined-treatment (e. g., exercise and curcumin) group (P &lt; 0.05). Heart rate (HR) corrected aortic AIx significantly decreases only in the combined-treatment group.
    CONCLUSIONS
    These findings suggest that regular endurance exercise combined with daily curcumin ingestion may reduce LV afterload to a greater extent than monotherapy with either intervention alone in postmenopausal women.

    DOI

  • Aerobic exercise training increases cerebral blood flow in postmenopausal women

    Nobuhiko, Akazawa, Youngju, Choi, Asako, Miyaki, Jun, Sugawara, Ryuichi, Ajisaka, Seiji, Maeda

    Artery Research    2012年06月  [査読有り]

  • Clinical application of “Curcumin”, a multi-functional substance

    Maeda,Seiji

    Anti-Aging Medicine    2012年05月

  • Arterial stiffness and lifestyle modification

    Miyaki, Asako, Maeda, Seiji

    The Journal of Physical Fitness and Sports Medicine   1 ( 2 ) 205 - 210  2012年01月

     概要を見る

    Previous research has established that both aging and obesity trigger elevation of arterial stiffness and that such elevation is an independent risk factor for cardiovascular morbidity and mortality. Changes in arterial stiffness are known to be caused by alterations in the balance of hormones, inflammatory, nervous system-related, and endothelium-derived vasoactive factors, and levels of oxidative stress - all of which are known to strongly affect vasoconstriction and vasodilation. Lifestyle modifications that promote the restriction of energy intake, maintenance of nutrient balance, and performance of regular aerobic exercise, can decrease arterial stiffness in elderly and obese individuals. In this review, we discuss the lifestyle strategies found effective in decreasing arterial stiffness in elderly and obese individuals via improvement of vasoactive functional factors.

  • The addition of whole-body vibration to a lifestyle modification on arterial stiffness in overweight and obese women

    Miyaki, A, Maeda, S, Choi, Y, Akazawa, N, Tanabe, Y, So, R, Tanaka, Y, Ajisaka, R

    Artery Research    2012年01月  [査読有り]

  • 閉経後女性の中心循環特性に対する有酸素性運動トレーニングの効果

    前田,清司

    健康医科学    2012年01月

  • Single bout of running exercise changes LC3-II expression in rat cardiac muscle

    Yuji Ogura, Motoyuki Iemitsu, Hisashi Naito, Ryo Kakigi, Chiaki Kakehashi, Seiji Maeda, Tatsuo Akema

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   414 ( 4 ) 756 - 760  2011年11月  [査読有り]

     概要を見る

    Macroautophagy (autophagy) is an intracellular catalytic process. We examined the effect of running exercise, which stimulates cardiac work physiologically, on the expression of microtubule-associated protein 1 light chain 3 (LC3)-II, an indicator of autophagy, as well as some autophagy-related proteins in rat cardiac muscle. The left ventricles were taken from rats immediately (0 h), and at 0.5 h, 1 h or 3 h after a single bout of running exercise on a treadmill for 30 min and also from rats in a rest condition. In these samples, we evaluated the level of LC3-II and p62, and the phosphorylation level of mammalian target of rapamycin (mTOR). Akt and AMP-activated protein kinase alpha (AMPK alpha) by Western blotting. The exercise produced a biphasic change in LC3-II, with an initial decrease observed immediately after the exercise and a subsequent increase 1 h thereafter. LC3-II then returned to the rest level at 3 h after the exercise. A negative correlation was found between the LC3-II expression and mTOR phosphorylation, which plays a role in inhibiting autophagy. The exercise increased phosphorylation of AMPK alpha, which stimulates autophagy via suppression of mTOR phosphorylation, immediately after exercise. The level of p62 and phosphorylated Akt was not altered significantly by the exercise. These results suggest for the first time that a single bout of running exercise induces a biphasic change in autophagy in the cardiac muscle. The exercise-induced change in autophagy might be partially mediated by mTOR in the cardiac muscle. (C) 2011 Elsevier Inc. All rights reserved.

    DOI

  • Age Differences in the Relation Between ACTN3 R577X Polymorphism and Thigh-Muscle Cross-Sectional Area in Women

    Hirofumi Zempo, Kai Tanabe, Haruka Murakami, Motoyuki Iemitsu, Seiji Maeda, Shinya Kuno

    GENETIC TESTING AND MOLECULAR BIOMARKERS   15 ( 9 ) 639 - 643  2011年09月  [査読有り]

     概要を見る

    The relation between ACTN3 R577X polymorphism and muscle mass in women has been reported, but its relation to age remains unclear. We investigated the relationship between ACTN3 R577X polymorphism and muscle mass in both middle-aged and elderly women. Two age groups (middle-aged and older) were formed among 162 healthy, nontraining Japanese women (mean +/- SE, 58.6 +/- 0.8 year). Their midthigh-muscle cross-sectional area (CSA) was assessed using magnetic resonance imaging, revealing no difference in thigh-muscle CSA among ACTN3 R577X genotypes in the middle-aged group (XX, 87.3 +/- 2.5 cm(2); RR&RX, 86.1 +/- 1.7 cm(2), p = 0.7). In contrast, the XX genotype in the older group had a smaller thigh-muscle CSA adjusted to body weight than the RR&RX genotypes (XX, 67.8 +/- 2.0 cm(2); RR&RX, 72.5 +/- 1.2 cm(2), p &lt; 0.05). The present study showed an association between ACTN3 R577X polymorphism and smaller thigh-muscle CSA in a group of elderly women but not in a group of middle-aged women.

    DOI

  • DHEA Administration Activates Local Bioactive Androgen Metabolism in Cancellous Site of Tibia of Ovariectomized Rats

    Jong-Hoon Park, Katsuji Aizawa, Motoyuki Iemitsu, Koji Sato, Takayuki Akimoto, Umon Agata, Seiji Maeda, Ikuko Ezawa, Naomi Omi

    CALCIFIED TISSUE INTERNATIONAL   89 ( 2 ) 105 - 110  2011年08月  [査読有り]

     概要を見る

    It is not known whether local androgen metabolism is involved in the mechanisms underlying the dehydroepiandrosterone (DHEA) administration-induced improvement of bone mineral density (BMD) in an estrogen-deficiency state. The aim of the present study was to clarify whether DHEA administration would improve local androgen metabolism and BMD in cancellous site of tibia of ovariectomized (OVX) rats. Twenty-two female rats, 6 weeks old, were randomized into three groups: sham-operated rats, OVX control rats, and OVX rats that received DHEA treatment. DHEA was administered intraperitoneally at 20 mg/kg body weight for 8 weeks. The concentrations of free testosterone and dihydrotestosterone (DHT) in cancellous site of tibia did not change as a result of ovariectomy, while the DHT concentration increased following DHEA administration. We revealed that DHEA administration improved the reduction of 17 beta- and 3 beta-hydroxysteroid dehydrogenases and clearly reversed the reduction of 5 alpha-reductase types 1 and 2 and androgen receptor in the cancellous site of tibia of OVX rats. DHEA administration suppressed estrogen deficiency relative to the decrease in the cancellous BMD, which was positively associated with local DHT concentration. These findings indicate that DHEA administration enhances local bioactive androgen metabolism in the cancellous tibia of young OVX rats, suggesting that local DHT may play a part in the DHEA administration-induced improvement of cancellous BMD.

    DOI

  • 一過性の水中運動が動脈スティフネスに及ぼす影響 : 陸上運動との差異

    野上, 順子, 斉藤, 陽子, 谷村, 祐子, 佐藤, 幸治, 大槻, 毅, 前田, 清司, 鰺坂, 隆一

    体力科學   60 ( 3 ) 269 - 277  2011年06月  [査読有り]

     概要を見る

    Objective: Aerobic exercise on land decreases arterial stiffness, however, the effect of exercise in water on arterial stiffness has not been clear. This study investigated the effect of a 15-min cycling exercise on land and that in water on pulse wave velocity (PWV) as an index of arterial stiffness. Methods: Nine healthy young men were randomly performed exercise on land and exercise in water equivalent to 50% of each maximum oxygen uptake on separate days. The PWV from carotid to femoral artery (aortic PWV) and femoral to posterior tibial artery (leg PWV) were measured at baseline and 15, 30, 60 min after exercise. Results: The heart rate in water was significantly lower during exercise than that on land. In addition, the carbon dioxide output and respiratory exchange ratio during exercise were significantly greater in water. Body temperature increased after the exercise on land but decreased after the exercise in water. Although the aortic PWV and leg PWV decreased concomitantly with decrease in SBP and DBP after the exercise on land, there were no significant changes after the exercise in water. Conclusion: Although acute exercise on land decreased arterial stiffness after exe

  • 04生-26-口-12 有酸素性運動トレーニングとクルクミン摂取が中心動脈伸展性に及ぼす影響(04.運動生理学,一般研究発表抄録)

    赤澤 暢彦, 鰺坂 隆一, 前田 清司

    日本体育学会大会予稿集   62   122 - 122  2011年

    DOI CiNii

  • 04生-26-口-13 成人肥満男性における性ホルモン血清濃度と動脈スティフネスの関係(04.運動生理学,一般研究発表抄録)

    成戸 丈紘, 田中 喜代次, 前田 清司, 野上 順子, 辻本 健彦, 赤澤 暢彦, 鰺坂 隆一

    日本体育学会大会予稿集   62   123 - 123  2011年

    DOI CiNii

  • Plasma Pentraxin 3 Concentration Increases in Endurance-Trained Men

    Asako Miyaki, Seiji Maeda, Takeshi Otsuki, Ryuichi Ajisaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   43 ( 1 ) 12 - 17  2011年01月  [査読有り]

     概要を見る

    MIYAKI, A., S. MAEDA, T. OTSUKI, and R. AJISAKA. Plasma Pentraxin 3 Concentration Increases in Endurance-Trained Men. Med. Sci. Sports Exerc., Vol. 43, No. 1, pp. 12-17, 2011. Introduction: Pentraxin 3 (PTX3), which is mainly produced by endothelial cells, macrophages, and smooth muscle cells in the atherosclerotic region, has a cardioprotective effect. Endurance exercise training has also been known to offer cardioprotection. However, the effect of regular endurance exercise on PTX3 is unknown. This study aimed to investigate whether plasma PTX3 concentrations increase in endurance-trained men. Ten young endurance-trained men and 12 age-and gender-matched sedentary controls participated in this study. Methods: We measured plasma PTX3 concentrations of the participants in each group. We also determined systemic arterial compliance (SAC) by using simultaneous M-mode ultrasound and arterial applanation tonometry of the common carotid artery and used HDL cholesterol (HDLC) as an index of cardioprotective effect. Results: Maximal oxygen uptake was significantly higher in the endurance-trained men than that in the sedentary controls. SAC and HDLC were significantly higher in the endurance-trained men than that in the sedentary controls (SAC = 1.74 +/- 0.11 vs 1.41 +/- 0.09 mL.mm Hg(-1), P &lt; 0.05; HDLC = 70 +/- 5 vs 57 +/- 4 mg.dL(-1), P &lt; 0.05). Plasma PTX3 concentrations were markedly higher in the endurance-trained men than that in the sedentary controls (0.93 +/- 0.11 vs 0.68 +/- 0.06 ng.mL(-1), P &lt; 0.05). Relationships between plasma PTX3 concentrations and SAC and HDLC were linear. Conclusions: This is the first study revealing that endurance-trained individuals had higher levels of circulating PTX3 than sedentary controls. PTX3 may play a partial role in endurance exercise training-induced cardioprotection.

    DOI

  • Acute running exercise temporarily changes autophagic activity in rat cardiac muscle

    OGURA Yuji, NAITO Hisashi, IEMITSU Motoyuki, KAKIGI Ryo, MAEDA Seiji, AKEMA Tatsuo

    J Physiol Sci   61 ( Supplement 1 ) S239  2011年

    J-GLOBAL

  • 高齢男性における一過性有酸素運動が動脈脈波伝播速度に及ぼす影響

    野上, 順子, 野上, 佳恵, 大槻, 毅, 前田, 清司, 鰺坂, 隆一

    日本臨床スポーツ医学会誌 = The journal of Japanese Society of Clinical Sports Medicine   19 ( 1 ) 50 - 56  2011年01月  [査読有り]

  • High circulating levels of oxidized LDL in strength-trained athletes

    Choi, Y, Maeda, S, Yosizawa, M, Tanabe, K, Miyaki, A, Tanabe, Y, Komine, H, Hirayama, A, Shiraki, H, Ajisaka, R

    Journal of Exercise Nutrition and Biochemistry   15 ( 2 ) 105-110  2011年01月  [査読有り]

  • Endurance exercise training enhances local sex steroidogenesis in skeletal muscle

    Katsuji Aizawa, Motoyuki Iemitsu, Seiji Maeda, Noboru Mesaki, Takashi Ushida, Takayuki Akimoto

    Medicine and Science in Sports and Exercise   43 ( 11 ) 2072 - 2080  2011年  [査読有り]

     概要を見る

    Purpose: Endurance training improves skeletal muscular function including energy metabolism and structure. Sex steroid hormones partly contribute to the exercise-induced muscular adaptations. Recently, we demonstrated that skeletal muscle contains steroidogenic converting enzymes to synthesize sex steroid hormones and an acute endurance exercise activates local steroidogenesis in skeletal muscle. However, whether chronic endurance training leads to enhanced steroidogenesis in skeletal muscle is unknown. Here, we examined changes in steroidogenic enzymes and sex steroid hormones in the skeletal muscle after chronic endurance exercise training. Methods: Eleven male rats were divided into two groups: sedentary (n = 6) and trained (n = 5). Endurance training was performed on a treadmill (30 m•min, 30 min) for 5 d•wk for 12 wk. The posttraining harvesting was performed 48 h after the last exercise training. Results: The mRNA expressions of 3β-HSD, aromatase cytochrome P450, and 5α-reductase in the skeletal muscle of trained rats were significantly higher than those of sedentary rats (P &lt
    0.05). The protein expressions of aromatase cytochrome P450 and 5α-reductase in the skeletal muscle of trained rats were also significantly higher than those of sedentary rats (P &lt
    0.05). The muscular dihydrotestosterone (DHT) concentrations in the skeletal muscle of trained rats were significantly higher than those of sedentary rats (P &lt
    0.01), but there was no change in dehydroepiandrosterone, total testosterone, free testosterone, and estradiol. Furthermore, muscle weight corrected for body weight of trained rats was moderately correlated with the level of muscular DHT concentration in trained rats (r = 0.41, P &lt
    0.05). Conclusions: Endurance exercise training enhances the muscular DHT concentration through 5α-reductase in the skeletal muscle of rats, suggesting that local bioactive androgen metabolism may participate in exercise training-induced skeletal muscular adaptation. © 2011 by the American College of Sports Medicine.

    DOI

  • Plasma pentraxin 3 concentration increases in endurance-trained men

    Asako Miyaki, Seiji Maeda, Takeshi Otsuki, Ryuichi Ajisaka

    Medicine and Science in Sports and Exercise   43 ( 1 ) 12 - 17  2011年01月  [査読有り]

     概要を見る

    Introduction: Pentraxin 3 (PTX3), which is mainly produced by endothelial cells, macrophages, and smooth muscle cells in the atherosclerotic region, has a cardioprotective effect. Endurance exercise training has also been known to offer cardioprotection. However, the effect of regular endurance exercise on PTX3 is unknown. This study aimed to investigate whether plasma PTX3 concentrations increase in endurance-trained men. Ten young endurance-trained men and 12 age- and gender-matched sedentary controls participated in this study. Methods: We measured plasma PTX3 concentrations of the participants in each group. We also determined systemic arterial compliance (SAC) by using simultaneous M-mode ultrasound and arterial applanation tonometry of the common carotid artery and used HDL cholesterol (HDLC) as an index of cardioprotective effect. Results: Maximal oxygen uptake was significantly higher in the endurance-trained men than that in the sedentary controls. SAC and HDLC were significantly higher in the endurance-trained men than that in the sedentary controls (SAC = 1.74 ± 0.11 vs 1.41 ± 0.09 mL•mm Hg -1, P &lt
    0.05
    HDLC = 70 ± 5 vs 57 ± 4 mg•dL, P &lt
    0.05). Plasma PTX3 concentrations were markedly higher in the endurance-trained men than that in the sedentary controls (0.93 ± 0.11 vs 0.68 ± 0.06 ng•mL, P &lt
    0.05). Relationships between plasma PTX3 concentrations and SAC and HDLC were linear. Conclusions: This is the first study revealing that endurance-trained individuals had higher levels of circulating PTX3 than sedentary controls. PTX3 may play a partial role in endurance exercise training-induced cardioprotection. © 2010 by the American College of Sports Medicine.

    DOI PubMed

  • VEGF signaling is disrupted in the heart of mice lacking estrogen receptor (Original article peer reviewed)

    Jesmin, S, Mowa,C.N, Maeda,S, Shimojo,N, Iemitsu,M, Sakuma,I, Miyauchi,T, Hiroe,M, Iwashima,Y, Hattori,Y, Yamaguchi,N

    European Journal of Pharmacology   641 ( 2-3 ) 168 - 178  2010年10月  [査読有り]

    DOI

  • Oxidative stress and arterial stiffness in strenth and endurance-trained athletes

    Choi, Y, Maeda, S, Otsuki, T, Miyaki, A, Shimojo, N, Shiraki, H, Ajisaka, R

    Artery Research   4   52-58  2010年08月  [査読有り]

  • Single Bout of Exercise Modulates Autophagy in Rat Cardiac Muscles

    Ogura Yuji, Iemitsu Motoyuki, Kakigi Ryo, Maeda Seiji, Naito Hisashi, Akema Tatsuo

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   42 ( 5 ) 635 - 636  2010年05月  [査読有り]

    DOI

  • Additive Beneficial Effects of Lactotripeptides Intake With Regular Exercise on Endothelium-Dependent Dilatation in Postmenopausal Women

    Mutsuko Yoshizawa, Seiji Maeda, Asako Miyaki, Maiko Misono, Youngju Choi, Nobutake Shimojo, Ryuichi Ajisaka, Hirofumi Tanaka

    AMERICAN JOURNAL OF HYPERTENSION   23 ( 4 ) 368 - 372  2010年04月  [査読有り]

     概要を見る

    BACKGROUND
    Peripheral conduit artery endothelium-dependent dilatation decreases with aging in humans. Lactotripeptides (LTPs) and regular exercise can improve endothelium-dependent dilatation, but combining these lifestyle modifications may be more effective than either treatment alone. We conducted a randomized, place-controlled trial with four different intervention arms.
    METHODS
    A total of 43 postmenopausal women (50-65 years old) were randomly divided into placebo, LTP, exercise and placebo (Ex+placebo), or exercise and LTP (Ex+LTP) groups. LTP or placebo administered orally for 8 weeks. The exercise groups completed an 8-week moderate aerobic exercise (walking or cycling) intervention.
    RESULTS
    There were no statistically significant differences in baseline flow-mediated dilatation (FMD) and most other key dependent variables among the groups. FMD significantly increased in the LTP, Ex+placebo, and Ex+LTP groups whereas no such changes were observed in the placebo control group. The magnitude of increases in FMD was significantly greater in the Ex+LTP group than other intervention groups.
    CONCLUSION
    We concluded that LIP ingestion combined with regular aerobic exercise improves endothelium-dependent dilatation to a greater extent than monotherapy with either intervention alone in postmenopausal women.

    DOI

  • Acute exercise activates local bioactive androgen metabolism in skeletal muscle

    Katsuji Aizawa, Motoyuki Iemitsu, Seiji Maeda, Takeshi Otsuki, Koji Sato, Takashi Ushida, Noboru Mesaki, Takayuki Akimoto

    STEROIDS   75 ( 3 ) 219 - 223  2010年03月  [査読有り]

     概要を見る

    Androgens, Such as testosterone, play important roles in regulation of diverse physiological process of target tissues. Recently, we reported that steroidogenic enzymes exist in skeletal Muscle and regulate local production of testosterone in response to exercise. Testosterone is transformed into a bioactive androgen metabolite, dihydrotestosterone (DHT) by 5 alpha-reductase. However, it is unclear whether exercise stimulates local bioactive androgen metabolism in the skeletal muscle in both sexes. In the present study, we examined sex differences in the levels of dehydroepiandrosterone (DHEA), free testosterone, DHT, and steroidogenesis-related enzymes 5 alpha-reductase and androgen receptor (AR) in rat&apos;s skeletal muscle before and after a single bout of exercise. Basal muscular free testosterone and DHT levels were higher in males than females, whereas the levels of DHEA did not differ between the sexes. Muscular DHEA, free testosterone, and DHT levels were increased in both sexes after the exercise. There were no differences of 5 alpha-reductase and AR transcripts and proteins between the sexes, and the expression of 5 alpha-reductase was significantly increased in both sexes after the exercise. Finally, the expression of AR was significantly higher in female rats, but not in males after the exercise. These data Suggest that acute exercise enhances the local bioactive androgen metabolism in the skeletal Muscle of both sexes. (C) 2009 Elsevier Inc. All rights reserved.

    DOI

  • ACTN3 Polymorphism Affects Thigh Muscle Area

    H. Zempo, K. Tanabe, H. Murakami, M. Iemitsu, S. Maeda, S. Kuno

    INTERNATIONAL JOURNAL OF SPORTS MEDICINE   31 ( 2 ) 138 - 142  2010年02月  [査読有り]

     概要を見る

    Muscle mass is an important factor influencing the activity of daily living in older adults. We aimed to investigate whether alpha-actinin-3 (ACTN3) gene R577X polymorphism affects muscle mass in older Japanese women. A total of 109 women (mean +/- SD, 64.1 +/- 6.0 years) were genotyped for the R/X variant of ACTN3. Mid-thigh muscle cross-sectional area (CSA) was assessed using MRI and compared using analysis of covariance models adjusted for body weight. In addition, physical activity and protein intake were measured as the living environmental factors affecting muscle mass. The ACTN3 R577X genotype distributions of the subjects were 19, 63 and 27 for the RR, RX, and XX genotypes, respectively. No differences in physical activity and protein intake were observed among the genotypes. The XX genotype showed lower thigh muscle CSA compared with RR&RX genotype (mean +/- SEM; XX: 69.1 +/- 1.8 cm(2), RR&RX: 73.6 +/- 1.1 cm(2); p &lt; 0.05). The results of the present study suggest that ACTN3 R577X polymorphism influences muscle mass in older Japanese women.

    DOI

  • Endothelin antagonist bosentan at high-dose on human arterial compliance (Distensibility) before and after exercise training

    Miyauchi Yumi, Seiji Maeda, Sugawara Jun, Shimojo Nobutake, Jesmin Subrina, Sakai Satoshi, Watanabe Shigeyuki, Aonuma Kazutaka, Miyauchi Takashi

    JOURNAL OF PHARMACOLOGICAL SCIENCES   112   243P  2010年  [査読有り]

  • Is Pentraxin 3 Involved in Obesity-Induced Decrease in Arterial Distensibility

    Asako Miyaki, Seiji Maeda, Mutsuko Yoshizawa, Maiko Misono, Hiroyuki Sasai, Nobutake Shimojo, Kiyoji Tanaka, Ryuichi Ajisaka

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   17 ( 3 ) 278 - 284  2010年  [査読有り]

     概要を見る

    Aim: Obesity is a strong risk factor for cardiovascular morbidity and mortality. In addition, decreased central arterial distensibility is recognized as an independent risk factor for cardiovascular disease (CVD). Obese subjects exhibit low arterial distensibillity; however, the mechanism responsible for the decrease in arterial distensibility in obese subjects has not yet been elucidated. Pentraxin 3 (PTX3), a recently identified member of the pentraxin family of proteins, is produced in areas of atherosclerosis. A recent study has revealed that the PTX3 level may indicate the vascular inflammatory status. The aim of this study was to investigate plasma PTX3 concentrations and arterial distensibility in obese subjects.
    Methods: Eleven obese men (age: 44 +/- 2 years, body mass index [BMI]: 32 +/- 1 kg/m(2)) and 14 non-obese men (age: 42 +/- 2 years, BMI: 26 +/- 1 kg/m(2)) participated in this study. We measured arterial compliance (using simultaneous B-mode ultrasound and arterial applanation tonometry of the common carotid artery); beta-stiffness index, an index of arterial compliance adjusted for distending pressure; and plasma PTX3 concentrations.
    Results: Arterial compliance was significantly lower and the beta-stiffness index was significantly higher in obese men than in non-obese men. Plasma PTX3 concentration was markedly higher in obese than non-obese men.
    Conclusions: Obese men have lower arterial distensibility and higher circulating PTX3 levels than non-obese men; therefore, higher PTX3 levels and decreased arterial distensibility coexist in obese men. The high PTX3 concentrations in obese men may be involved in the mechanism underlying the obesity-induced decrease in arterial distensibility.

  • Effects of aging on leg pulse wave velocity response to single-leg cycling

    Jun, Sugawara, Takeshi, Otsuki, Seiji, Maeda

    Artery Research   4   94-97  2010年01月  [査読有り]

  • Racial differences in relation between carotid and radial augmentation index

    Jun, Sugawara, Hidehiko, Komine, Mutsuko, Yoshizawa, Takashi, Tarumi, Seiji, Maeda, Hirofumi, Tanaka

    Artery Research   4   15-18  2010年01月  [査読有り]

  • Epicardial fat tissue: relationship with cardiorespiratory fitness in men

    Maeng-Kyu, Kim, Kiyoji, Tanaka, Mi-Ji, Kim, Tomoaki, Matsuo, Tsugio, Tomita, Hiroyuki, Ohkubo, Seiji, Maeda, Ryuichi, Ajisaka

    Medicine & Science in Sports & Exercise   42   463-469  2010年01月  [査読有り]

  • 中高齢男性における性ホルモンと動脈スティフネスの関係に運動習慣が及ぼす影響

    成戸 丈紘, 谷村 祐子, 野上 佳恵, 佐藤 幸治, 野上 順子, 前田 清司, 鰺坂 隆一

    体力科学   58 ( 6 ) 780 - 780  2009年12月

  • Comparison of epicardial, abdominal and regional fat compartments in response to weight loss

    M. -K. Kim, K. Tanaka, M. -J. Kim, T. Matuso, T. Endo, T. Tomita, S. Maeda, R. Ajisaka

    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES   19 ( 11 ) 760 - 766  2009年12月  [査読有り]

     概要を見る

    Background and aims: Echocardiographic measurement of epicardial fat (EF) seems to be a reliable and diagnostic marker of visceral. adipose tissue (VAT). However, the weight loss-induced changes in EF have not been compared with those in VAT or the truncal. depot. In this study, we aimed to compare the weight loss-induced changes in EF, VAT and other regional fat compartments in obese men.
    Methods and results: In this study, 27 moderately obese men (age 45.8 +/- 1.7 years; body mass index 30.5 +/- 0.7 kg/m(2)) followed a daily low-calorie diet as part of a clinical. 12-week weight loss interventional. study. We evaluated the EF thickness by transthoracic echocardiography, assessed the abdominal fat tissues by computed tomography scans, and examined the regional and whole body fat compartments by dual X-ray absorptiometry. An average decrease of 26.8% in the initial calorie intake corresponded to post-program reductions of 17.2%, 11.0%, 16.6%, and 29.8% in EF thickness (P &lt; 0.001), body mass, percentage fat mass, and abdominal fat compartments, respectively. The percentage change in VAT in response to weight loss was twice as high as the substantial. change in EF tissue (P &lt; 0.001).
    Conclusion: The results of the study suggest that a low-calorie diet-induced weight toss decreases EF thickness. Moderate diet-induced weight loss alone may represent an effective nonpharmacological strategy for reducing EF, which is a unique, pathogenic fat depot and an emerging marker of VAT. (c) 2009 Elsevier B.V. All rights reserved.

    DOI

  • 1-O-03 Exercise training improves decrease in cardiac oxidative metabolic capacity through PPARα signaling in a rat model of menopause(The Proceedings of the 17th Annual Meetings of Japan Society of Exercise and Sports Physiology Jury 25-26, (Tokyo))

    IEMITSU, Motoyuki, HOON, Park Jong, SATO, Koji, MAEDA, Seiji, OMI, Naomi, TABATA, Izumi

    Advances in exercise and sports physiology   15 ( 2 ) 49  2009年12月  [査読有り]

  • Additive beneficial effects of lactotripeptides and aerobic exercise on arterial compliance in postmenopausal women

    Mutsuko Yoshizawa, Seiji Maeda, Asako Miyaki, Maiko Misono, Youngju Choi, Nobutake Shimojo, Ryuichi Ajisaka, Hirofumi Tanaka

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   297 ( 5 ) H1899 - H1903  2009年11月  [査読有り]

     概要を見る

    Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N, Ajisaka R, Tanaka H. Additive beneficial effects of lactotripeptides and aerobic exercise on arterial compliance in postmenopausal women. Am J Physiol Heart Circ Physiol 297: H1899-H1903, 2009. First published September 25, 2009; doi:10.1152/ajpheart.00433.2009.-Central arterial compliance plays an important role in the functional abilities of the vasculature. Two active tripeptides, valine-proline-proline and isoleucineproline-proline, were isolated from sour milk and were referred to as lactotripeptides (LTP). Because LTP appears to act as an angiotensin-converting enzyme inhibitor, it is plausible to hypothesize that LTP improves arterial compliance. We determined the effects of LTP ingestion alone or in combination with regular aerobic exercise on arterial compliance. A total of 55 postmenopausal women (50-65 yr old) were randomly divided into four groups: placebo, LTP, exercise and placebo (Ex + placebo), or exercise and LTP (Ex + LTP). LTP or placebo was administered orally for 8 wk. The exercise groups completed an 8-wk moderate aerobic exercise intervention. There were no differences in baseline arterial compliance and most other key dependent variables among the groups. Carotid arterial compliance increased significantly in the LTP (0.93 +/- 0.07 vs. 0.99 +/- 0.08 mm(2)/mmHg . 10(-1)), Ex + placebo (0.92 +/- 0.04 vs. 1.00 +/- 0.05 mm2/mmHg . 10(-1)), and Ex + LTP groups (0.86 +/- 0.06 vs. 1.00 +/- 0.06 mm(2)/mmHg . 10(-1)), whereas no such changes were observed in the placebo control group (0.86 +/- 0.06 vs. 0.85 +/- 0.07 mm(2)/mmHg . 10(-1)). The magnitude of increases in carotid arterial compliance was significantly greater in the Ex + LTP group (19 +/- 4%) than in other groups. The improvements in arterial compliance with LTP were associated with the corresponding reductions in arterial blood pressure and plasma angiotensin II concentrations. We concluded that LTP ingestion improves carotid arterial compliance and that the combination of LTP ingestion and regular exercise is additive and synergistic in improving arterial compliance in postmenopausal women.

    DOI

  • PPARG Genotype Accounts for Part of Individual Variation in Body Weight Reduction in Response to Calorie Restriction

    Tomoaki Matsuo, Yoshio Nakata, Yasutomi Katayama, Motoyuki Iemitsu, Seiji Maeda, Tomohiro Okura, Maeng-Kyu Kim, Hiroyuki Ohkubo, Kikuko Hotta, Kiyoji Tanaka

    OBESITY   17 ( 10 ) 1924 - 1931  2009年10月  [査読有り]

     概要を見る

    Several studies indicate that expression of the peroxisome proliferator-activated receptor gamma(PPARG) gene is influenced by calorie restriction. The aim of this study was to investigate whether PPARG gene variations are associated with weight reduction and changes in coronary heart disease (CHD) risk factors in response to a 14-week calorie restriction. In total, 95 middle-aged, Japanese women (BMI &gt;= 25 kg/m(2)) enrolled as subjects for 14 weeks and attended weekly dietary lectures instructing them on how to consume a nutritionally balanced diet of 1,200 kcal/day. Eight single-nucleotide polymorphisms (SNPs) in the PPARG gene (rs1801282 (Pro/Ala), rs2292101, rs2959272, rs1386835, rs709158, rs1175540, rs1175544, and rs1797912) were analyzed. Body weight decreased significantly (-7.7 +/- 3.1 kg; -11.3 +/- 4.4%) during the intervention. Six PPARG SNPs (rs2959272, rs1386835, rs709158, rs1175540, rs1175544, and rs1797912) were significantly associated with the weight reduction, with rs1175544 having the strongest association (P = 0.004). No differences across the rs1175544 genotypes were observed in any of the blood analyses or in blood pressure. In a multiple regression analysis, the rs1175544 genotypes accounted for 7% of the total weight reduction variance. These data suggest that one SNP of the PPARG genotype accounted for a significant portion of the total body weight reduction variance in response to a short-term intervention consisting of calorie restriction; however, no relationship was found between these SNPs and the changes in CHD risk factors which accompanied weight loss.

    DOI

  • Effect of Habitual Aerobic Exercise on Body Weight and Arterial Function in Overweight and Obese Men

    Asako Miyaki, Seiji Maeda, Mutsuko Yoshizawa, Maiko Misono, Yoko Saito, Hiroyuki Sasai, Maeng-Kyu Kim, Yoshio Nakata, Kiyoji Tanaka, Ryuichi Ajisaka

    AMERICAN JOURNAL OF CARDIOLOGY   104 ( 6 ) 823 - 828  2009年09月  [査読有り]

     概要を見る

    The effect of habitual exercise on vascular function, including central arterial distensibility and endothelial function, in obese subjects has not yet been clarified. We investigated whether aerobic exercise training affects central arterial distensibility and endothelial function in middle-age overweight and obese men. A total of 21 overweight and obese men (age 50 +/- 2 years, body mass index 30 +/- 1 kg/m(2)) completed a 12-week aerobic exercise intervention. Aerobic exercise training significantly reduced their body weight and resulted in a significant decrease in body mass index. After the weight-reduction exercise program, carotid arterial compliance (determined by simultaneous B-mode ultrasonography and arterial applanation tonometry on the common carotid artery) significantly increased; and the beta-stiffness index, an index of arterial compliance adjusted for distending pressure, significantly decreased. The concentrations of plasma endothelin-1, a potent vasoconstrictor peptide produced by vascular endothelial cells, significantly decreased and plasma nitric oxide (measured as the stable end product [nitrite/nitrate]), a potent vasodilator produced by vascular endothelial cells, significantly increased after the weight-reduction exercise program. In conclusion, weight reduction by aerobic exercise training in overweight and obese men increased the central arterial distensibility. This increase might contribute to the improvement in endothelial function, as assessed by a decrease in endothelin-1 and an increase in nitric oxide, after exercise training-induced weight loss. (C) 2009 Elsevier Inc. All rights reserved. (Am J Cardiol 2009;104:823-828)

    DOI

  • EFFECTS OF HABITUAL EXERCISE AND CANDIDATE GENE POLYMORPHISMS RELATED TO BONE ON CALCANEAL QUANTITATIVE ULTRASOUND IN MIDDLE-AGED AND ELDERLY JAPANESE

    Hiroyuki Ohkubo, Yoshio Nakata, Michiko Fujimura, Takashi Miyauchi, Motoyuki Iemitsu, Seiji Maeda, Kiyoji Tanaka

    JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE   58 ( 4 ) 421 - 429  2009年08月  [査読有り]

     概要を見る

    The purpose of this study was to investigate the interaction of habitual exercise and candidate gene polymorphisms related to bone on osteo sono-assessment index (OSI) by quantitative ultrasound (QUS) in middle-aged and elderly Japanese. Participants were classified into exercise group (E; n = 172, 62.3 +/- 7.7 yr) and sedentary group (S; n = 65, 58.6 +/- 9.2 yr). The OSI was measured with AOS-100. DNA was extracted from blood, and single nucleotide polymorphism in vitamin D receptor, estrogen receptor a, and transforming growth factor-beta I were genotyped by TaqMan assay. Group E had significantly lower body weight and body mass index (BMI) than Group S. In men, although Group E was older than Group S, Group E had significantly higher OSI rather than Group S. There was no significant interaction between habitual exercise and each gene polymorphism on OSI. These results essentially remained unchanged even when analysis of covariance was applied after adjustment for age, body weight, and BMI. These results suggest habitual exercise and genetic factors have no interaction on OSI in middle-aged and elderly Japanese. Further investigations are needed to prove the interaction of other gene polymorphisms and exercise. (Jpn. J. Phys. Fitness Sports Med. 2009, 58 : 421 similar to 430)

  • Response to Letter to Editor of Csajbok E, Gavaller H, Csanady M, Forster T, and Nemes A

    Asako Miyaki, Seiji Maeda

    ANGIOLOGY   60 ( 4 ) 518 - 518  2009年08月  [査読有り]

    DOI

  • Effect of 12 weeks of moderate-intensity resistance training on arterial stiffness: a randomised controlled trial in women aged 32-59 years

    M. Yoshizawa, S. Maeda, A. Miyaki, M. Misono, Y. Saito, K. Tanabe, S. Kuno, R. Ajisaka

    BRITISH JOURNAL OF SPORTS MEDICINE   43 ( 8 ) 615 - 618  2009年08月  [査読有り]

     概要を見る

    Background: Resistance training has been increasingly incorporated into the overall exercise programme because of its effect on muscle strength, functional capacity and osteoporosis. High-intensity resistance training increases arterial stiffness. However, the effect of moderate-intensity resistance training on arterial stiffness is unknown.
    Objective: To determine whether 12 weeks of moderate-intensity resistance training increases arterial stiffness in middle-aged women.
    Methods: 35 middle-aged women (age range 32 to 59 years) volunteered to participate. The subjects were randomly assigned to one of three groups: resistance training (RT) group, aerobic exercise training (AET) group or control group. The RT and AET groups performed 12 weeks of moderate-intensity resistance training or aerobic exercise training (two days/week).
    Results: In the RT group, one-repetition maximum strength significantly increased after the intervention. Interestingly, aortic (carotid-femoral) pulse wave velocity (PWV; an index of arterial stiffness), and peripheral (femoral-ankle) PWV did not change with moderate-intensity resistance training. In contrast, in the AET group, carotid-femoral PWV significantly decreased after the intervention. Resistance training and aerobic exercise training did not affect blood pressure.
    Conclusions: This study found that moderate-intensity resistance training did not increase arterial stiffness in middle-aged women, which may have great importance for health promotion with resistance training.

    DOI

  • 04-27-K209-4 2年間のライフスタイル型運動プログラムが中年勤労者のメタボリックシンドロームに及ぼす影響(04.運動生理学,一般研究発表抄録,ひろしま発 ひとを育む体育・スポーツ)

    田辺, 解, 横山, 典子, 前田, 清司, 家光, 素行, 菅, 洋子, 難波, 秀行, 膳法, 浩史, 久野, 譜也

    日本体育学会大会予稿集   0 ( 60 ) 131  2009年08月

  • 運動習慣と骨関連遺伝子多型が中高年の超音波骨指標に及ぼす影響

    大久保 寛之, 中田 由夫, 藤村 透子, 宮内 卓, 家光 素行, 前田 清司, 田中 喜代次

    体力科学   58 ( 4 ) 421 - 429  2009年08月  [査読有り]

     概要を見る

    中高齢男女を対象として、運動と骨関連遺伝子多型が超音波骨指標(OSI)に及ぼす影響を年齢、体重で補正することにより、運動の有益性を検討した。運動習慣の有無によって、運動習慣のある中高齢者(E群)と運動習慣のない中高齢者(S群)の2群に分類した。対象者における各遺伝子多型(VDR、ERα、TGF-β1)において、計算した遺伝子型頻度と実際に観察された結果との間に有意差はなく、Hardy-Weinbergの平衡にあることが確認できた。OSIについて、運動習慣による主効果がすべての遺伝子多型で認められたが、遺伝子型による主効果は認めなかった。さらに、各遺伝子多型(VDR、ERα、TGF-β1)のいずれにおいても、運動習慣と遺伝子型による有意な交互作用は認めなかった。さらに、これらの交互作用を年齢、体重、BMIで補正して分析(二元配置の共分散分析)したが、結果に統計学的有意性は見られなかった。

  • Combination of polymorphisms in the beta 2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension

    Maiko Misono, Seiji Maeda, Motoyuki Iemitsu, Yoshio Nakata, Takeshi Otsuki, Jun Sugawara, Hirofumi Zempo, Mutsuko Yoshizawa, Asako Miyaki, Shinya Kuno, Mitsuo Matsuda, Ryuichi Ajisaka

    JOURNAL OF HYPERTENSION   27 ( 7 ) 1377 - 1383  2009年07月  [査読有り]

     概要を見る

    Objective Hypertension is a major risk factor for cardiovascular disease. Polymorphism in the beta(2)-adrenergic receptor (ADRB2) and nitric oxide synthase 3 (NOS3) genes is associated with clinical cardiovascular phenotypes. The Arg16Gly and Glu298Asp polymorphisms of ADRB2 and NOS3 genes, respectively, have been reported to be associated with hypertension. We hypothesized that a combination of these two polymorphisms increases the risk for hypertension. Hence, we examined the effect of this combination of single-nucleotide polymorphisms on the risk for hypertension.
    Methods Our cross-sectional study comprised 402 middle-aged and elderly human participants. We determined the genotypes of Arg16Gly and Glu298Asp single-nucleotide polymorphisms in ADRB2 and NOS3, respectively, by TaqMan PCR method; we also measured the resting blood pressure.
    Results The odds ratio for the presence of hypertension in individuals having the Gly/Gly genotype of ADRB2 compared with those having the other genotypes (Arg/Arg and Arg/Gly) was 2.87. With regard to the Glu298Asp polymorphism in NOS3, the odds ratio for the presence of hypertension in individuals having the Glu/Glu genotype of NOS3 when compared with those having the other genotypes (Asp/Asp and Asp/Glu) was 2.79. Interestingly, the odds ratio was 7.64 for individuals having a combination of the Gly/Gly genotype of ADRB2 and Glu/Glu genotype of NOS3 when compared with those having a combination of Arg/Arg and Arg/Gly genotypes of ADRB2 and Asp/Asp and Asp/Glu genotypes of NOS3.
    Conclusion We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans. J Hypertens 27:1377-1383 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

    DOI

  • Reduction in alpha-adrenergic receptor-mediated vascular tone contributes to improved arterial compliance with endurance training

    Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Takashi Yokoi, Seiji Maeda, Hirofumi Tanaka

    INTERNATIONAL JOURNAL OF CARDIOLOGY   135 ( 3 ) 346 - 352  2009年07月  [査読有り]

     概要を見る

    Background: Regular aerobic exercise improves large artery compliance in middle-aged and older humans. However, the underlying mechanisms are unknown. We tested the hypothesis that the improved central arterial compliance with endurance training is mediated by decreased a-adrenergic tone and/or increased endothelial function.
    Methods: Seven sedentary healthy adults (60 +/- 3 years) underwent systemic a-adrenergic blockade (phentolamine) and nitric oxide synthase (NOS) inhibition using N(G)-monomethyl-L-arginine in sequence before and after a 3-month moderate endurance training (walk/jog, 4-5 days/week). Phentolamine was given first to isolate the contribution of nitric oxide to arterial compliance by minimizing reflex suppression of sympathetic tone resulting from systemic NOS inhibition as well as to assess the a-adrenergic receptor-mediated modulation of arterial compliance.
    Results: Baseline arterial compliance (via simultaneous ultrasound and applanation tonometry on the carotid artery) increased 34 +/- 12% after exercise training (P &lt; 0.01). When alpha-adrenergic blockade was performed, arterial compliance increased 37 +/- 6% (P &lt; 0.01) before the exercise training but did not change significantly after the training. Decreases in arterial compliance from the a-adrenergic blockade to the subsequent additional NOS blockade were not different before and after exercise training.
    Conclusion: Our results suggest that the reduction in a-adrenergic receptor-mediated vascular tone contributes to the improved central arterial compliance with endurance training. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

    DOI

  • Effect of Weight Reduction With Dietary Intervention on Arterial Distensibility and Endothelial Function in Obese Men

    Asako Miyaki, Seiji Maeda, Mutsuko Yoshizawa, Maiko Misono, Yoko Saito, Hiroyuki Sasai, Takayuki Endo, Yoshio Nakata, Kiyoji Tanaka, Ryuichi Ajisaka

    ANGIOLOGY   60 ( 3 ) 351 - 357  2009年06月  [査読有り]

     概要を見る

    Obesity and reduction in central arterial distensibility, respectively, have been identified as powerful and independent risk factors for cardiovascular disease. However, the effect of weight reduction on central arterial function in obese Subjects has not yet been clarified. We investigated whether low-calorie diet-induced weight reduction affects central arterial distensibility and endothelial function in middle-aged Obese men. Twelve obese men (age: 45 +/- 2 yrs, BMI: 30 +/- 1 kg/m(2)) completed a 12-week dietary intervention. Caloric restriction induced significantly weight loss and decrease in BMI. After the program, carotid arterial compliance significantly increased and beta-stiffness index and aortic pulse-wave velocity remarkably decreased. Concentrations of plasma endothelin-1 (ET-1) significantly decreased and plasma nitric oxide (NO) markedly increased after the program. Weight reduction by low-calorie diet in obese men increases central arterial distensibility, which may contribute to the improvement in endothelial function, as noted by a decrease in ET-I and an increase in NO.

    DOI

  • Involvement of endothelin-1 in habitual exercise-induced increase in arterial compliance

    S. Maeda, J. Sugawara, M. Yoshizawa, T. Otsuki, N. Shimojo, S. Jesmin, R. Ajisaka, T. Miyauchi, H. Tanaka

    ACTA PHYSIOLOGICA   196 ( 2 ) 223 - 229  2009年06月  [査読有り]

     概要を見る

    Habitual aerobic exercise results in a significant increase in central arterial compliance. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and could play a role in mediating the habitual aerobic exercise-induced increase in central arterial compliance. The aim of the present study was to examine whether ET-1 is involved in the mechanisms underlying the increase in central arterial compliance with aerobic exercise training.
    Seven apparently healthy middle-aged and older (60 +/- 3 years) adults underwent systemic endothelin-A/B (ET(A/B))-receptor blockade (500 mg of Tracleer((R))) before and after 12 weeks of aerobic exercise training (70 +/- 1% of maximal heart rate, 44 +/- 2 min day(-1), 4.4 +/- 0.1 days week(-1)).
    Basal carotid arterial compliance (via simultaneous B-mode ultrasound and arterial applanation tonometry on the common carotid artery) increased significantly after exercise training. Resting plasma ET-1 concentration decreased significantly after exercise training. Before exercise intervention, carotid arterial compliance increased significantly with the administration of the ET(A/B)-receptor blockade. After training, however, increases in carotid arterial compliance previously observed with the ET(A/B)-receptor blockade before training were abolished.
    Regular aerobic exercise training enhances central arterial compliance in middle-aged and older humans. The increase in arterial compliance was associated with the corresponding reduction in plasma ET-1 concentration as well as the elimination of ET-1-mediated vascular tone. These results suggest that reductions in ET-1 may be an important mechanism underlying the beneficial effect of exercise training on central artery compliance.

    DOI

  • 高齢女性においてラクトトリペプチドはアンジオテンシンII抑制と内皮前駆細胞の動員を介して血管内皮細胞機能を改善させる(Lactotripeptide Ameliorates Vascular Endothelial Cell Function via Inhibition of Angiotensin II and Recruitment of Endothelial Progenitor Cells in Elderly Women)

    Shimojyoh Nobutake, Maruyama Hidekazu, Yoshizawa Mutsuko, Niwayama Jun, Miyahara Takaaki, Miyaki Asako, Misono Maiko, Tajiri Kazuko, Miyauchi Takashi, Maeda Seiji, Aonuma Kazutaka

    Circulation Journal   73 ( Suppl.I ) 664 - 664  2009年03月

  • PJ-468 Lactotripeptide Ameliorates Vascular Endothelial Cell Function via Inhibition of Angiotensin II and Recruitment of Endothelial Progenitor Cells in Elderly Women(PJ079,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Poster Session (Japanese)

    Shimojo,Nobutake, Maruyama,Hidekazu, Yoshizawa,Mutsuko, Niwayama,Jun, Miyahara,Takaaki, Miyaki,Asako, Misono,Maiko, Tajiri,Kazuko, Miyauchi,Takashi, Maeda,Seiji, Aonuma,Kazutaka

    Circulation journal : official journal of the Japanese Circulation Society   73 ( 0 ) 664  2009年03月  [査読有り]

  • THE EFFECTS OF DEHYDROEPIANDROSTERONE ADMINISTRATION AND ENDURANCE EXERCISE TRAINING ON PREVENTING OVARIECTOMY-INDUCED BONE LOSS

    Jong Hoon Park, Katsuji Aizawa, Motoyuki Iemitsu, Seiji Maeda, Naomi Omi

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59 ( Suppl. 1 ) 228 - 228  2009年  [査読有り]

  • Aerobic exercise training reduces epicardial fat in obese men

    Maeng-Kyu Kim, Tsugio Tomita, Mi-Ji Kim, Hiroyuki Sasai, Seiji Maeda, Kiyoji Tanaka

    JOURNAL OF APPLIED PHYSIOLOGY   106 ( 1 ) 5 - 11  2009年01月  [査読有り]

     概要を見る

    Kim MK, Tomita T, Kim MJ, Sasai H, Maeda S, Tanaka K. Aerobic exercise training reduces epicardial fat in obese men. J Appl Physiol 106: 5-11, 2009. First published October 16, 2008; doi:10.1152/japplphysiol.90756.2008. -The purpose of this study was to determine the effects of exercise training on ventricular epicardial fat thickness in obese men and to investigate the relationship of the change in epicardial fat thickness to changes in abdominal fat tissue following exercise training. Twenty-four obese middle-aged men [ age, 49.4 +/- 9.6 yr; weight, 87.7 +/- 11.2 kg; body mass index (BMI), 30.7 +/- 3.3 kg/m(2); peak oxygen consumption, 28.4 +/- 7.2 ml (.) kg(-1) (.) min(-1); means +/- SD] participated in this study. Each participant completed a 12-wk supervised exercise training program (60-70% of the maximal heart rate; 60 min/day, 3 days/wk) and underwent a transthoracic echocardiography. The epicardial fat thickness on the free wall of the right ventricle was measured from both parasternal long- and short-axis views. The visceral adipose tissue ( VAT) and subcutaneous adipose tissues were measured by computed tomography. Following exercise training, the epicardial fat thickness was significantly decreased ( P &lt; 0.001). The percentage change of epicardial fat thickness was twice as high compared with those of waist, BMI, and body weight of original values ( P &lt; 0.05). There was a significant relationship (r = 0.525, P = 0.008) between changes in the epicardial fat thickness and VAT with exercise training. Stepwise multiple regression analysis revealed that the change in VAT, change in systolic blood pressure, and change in quantitative insulin sensitivity check index were independently related to the change epicardial fat thickness ( P &lt; 0.05). The ventricular epicardial fat thickness is reduced significantly after aerobic exercise training and is associated with a decrease in VAT. These results suggest that aerobic exercise training may be an effective nonpharmacological strategy for decreasing the ventricular epicardial fat thickness and visceral fat area in obese middle-aged men.

    DOI

  • 中高年齢者における総ホモシステイン血漿濃度に対する運動トレーニング効果

    鰺坂隆一, 大槻, 毅, 田辺, 匠, 村上晴香, 前田清司, 久野譜也, 松田光生

    心臓リハビリテーション   14 ( 1 ) 257-262  2009年01月  [査読有り]

  • 運動時の動脈エラスタンスの増大と動脈コンプライアンスの低下は持久性トレーニング者で非トレーニング者に比べて大きい

    大槻 毅, 家光 素行, 斉藤 陽子, 谷村 祐子, 鰺坂 隆一, 前田 清司

    体力科学   57 ( 6 ) 714 - 714  2008年12月

  • 120. 自発走運動およびデヒドロエピアンドロステロン投与が卵巣摘出ラットの骨代謝に及ぼす効果(運動器,一般口演,第63回日本体力医学会大会)

    朴, 鍾薫, 相澤, 勝治, 家光, 素行, 前田, 清司, 麻見, 直美

    体力科學   57 ( 6 ) 692  2008年12月  [査読有り]

  • αアクチニン3遺伝子多型がサルコペニアに与える影響(生理科学的研究/その他,一般口演,第63回日本体力医学会大会)

    膳法, 浩史, 田辺, 解, 村上, 晴香, 家光, 素行, 前田, 清司, 中野, 由香利 ダニエーラ, 久野, 譜也

    体力科學   57 ( 6 ) 915  2008年12月

  • 減量及び筋力トレーニングが中年女性のメタボリックシンドロームと筋因子に及ぼす影響(生活・健康,一般口演,第63回日本体力医学会大会)

    田辺, 解, 横山, 典子, 膳法, 浩史, 前田, 清司, 久野, 譜也

    体力科學   57 ( 6 ) 860  2008年12月

  • ライフスタイル型運動プログラムに参加した中年勤労男性における運動の習慣化を促進させる要因(生活・健康,一般口演,第63回日本体力医学会大会)

    横山, 典子, 田辺, 解, 大塚, 貞明, 前田, 清司, 久野, 譜也

    体力科學   57 ( 6 ) 867  2008年12月

  • β2アドレナリン受容体と内皮型NO合成酵素の遺伝子多型の組み合わせは高血圧の発症リスクを増大させる(呼吸・循環,一般口演,第63回日本体力医学会大会)

    美園, 麻衣子, 前田, 清司, 家光, 素行, 中田, 由夫, 大槻, 毅, 菅原, 順, 膳法, 浩史, 吉澤, 睦子, 宮木, 亜沙子, 崔, 英珠, 久野, 譜也, 松田, 光生, 鰺坂, 隆一

    体力科學   57 ( 6 ) 708  2008年12月

  • 432. 肥満男性の食事制限による減量が動脈機能に及ぼす影響(生活・健康,一般口演,第63回日本体力医学会大会)

    宮木, 亜沙子, 前田, 清司, 吉澤, 睦子, 美園, 麻衣子, 斉藤, 陽子, 笹井, 浩行, 中田, 由夫, 田中, 喜代次, 鰺坂, 隆一

    体力科學   57 ( 6 ) 848  2008年12月  [査読有り]

  • Inhibition of Angiotensin II and Recruitment of Endothelial Progenitor Cells by Lactotripeptide Administration Ameliorates Vascular Endothelial Cell Function in Elderly Women

    Nobutake Shimojo, Hidekazu Maruyama, Mutsuko Yoshizawa, Jun Niwayama, Takaaki Miyahara, Maiko Misono, Asako Miyaki, Kazuko Tajiri, Takashi Miyauchi, Seiji Maeda

    CIRCULATION   118 ( 18 ) S1136 - S1137  2008年10月

  • Relationship Between Arterial Calcification and Bone Loss in a New Combined Model Rat by Ovariectomy and Vitamin D-3 Plus Nicotine

    Jong-Hoon Park, Naomi Omi, Motoyuki Iemitsu, Seiji Maeda, Ayako Kitajima, Toshiya Nosaka, Ikuko Ezawa

    CALCIFIED TISSUE INTERNATIONAL   83 ( 3 ) 192 - 201  2008年09月  [査読有り]

     概要を見る

    Epidemiological studies have reported an association between arterial calcification and bone loss after menopause. However, the underlying mechanism of the association remains unclear. Therefore, to explore the possible mechanisms of the association, we tried to develop a new combined model rat of ovariectomy (OVX, an animal model of osteoporosis) and vitanlin D-3 plus nicotine (VDN rate an animal model of arterial calcification). We tested them by using sham-operated control rats (SC), OVX control rats (OC), and OVX plus VDN-treated rats (OVN). Dissections were performed twice at 4 (4SC. 40C, and 4OVN) and 8 (8SC, 80C, and SOVN) weeks after treatment. 8OVN showed bone loss and arterial calcification. although 80C showed only bone loss. Moreover, arterial clacium content was associated with indexes of bone loss at 8 weeks. Thus, the OVN rat is considered a good model to examine the relationship of the two disorders after menopause. Additionally, the arterial endothelin-1 (ET-1, a potent regulator of arterial calcification) levels increased in both 4OVN and 8OVN, and the level was associated with arterial calcium content at 8 weeks. Furthermore, the arterial endothelial nitric oxide synthase (eNOS) protein, which is an enzyme that produces nitric oxide (an antiatherosclerotic substance), was significantly reduced in only 8OVN. Estrogens affect the alterations of the eNOS and ET-1 proteins. Therefore, we suggest that impairment of the ET-1- and NO-producing system in arterial tissue during periods of rapid bone loss by estrogen deficiency might be a mechanism of the relalionship between the two disorders seen in postmenopausal women.

    DOI

  • 04-12-153-8 中年女性における中等度レジスタンストレーニングが動脈スティフネスに及ぼす影響(運動生理学3,04.運動生理学,一般研究発表抄録)

    吉澤, 睦子, 前田, 清司, 田辺, 解, 久野, 譜也, 鰺坂, 隆一

    日本体育学会大会予稿集   0 ( 59 ) 134  2008年09月

  • Inhibitory Effect of Eicosapentaenoic Acid on Cardiomyocyte Hypertrophy via PPAR-alpha Upregulation

    Nobutake Shimojo, Satoshi Sakai, Seiji Maeda, Masaaki Soma, Subrina Jesmin, Takashi Miyauchi, Kazutaka Aonuma

    CIRCULATION RESEARCH   103 ( 5 ) E60 - E60  2008年08月  [査読有り]

  • Exercise-induced oxidative DNA damage and lymphocytopenia in sedentary young males

    Yuko Tanimura, Kazuhiro Shimizu, Kai Tanabe, Takeshi Otsuki, Ryohei Yamauchi, Yuichi Matsubara, Motoyuki Iemitsu, Seiji Maeda, Ryuichi Ajisaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   40 ( 8 ) 1455 - 1462  2008年08月  [査読有り]

     概要を見る

    Post high-intensity exercise lymphocytopenia is well documented, but its underlying mechanisms have not been fully elucidated. A possible mechanism is a reactive oxygen species-induced DNA damage after high-intensity exercise. Furthermore, lymphocyte apoptosis related to DNA damage might contribute to exercise-induced lymphocytopenia. Purpose: This study examined lymphocytopenia, lymphocyte oxidative DNA damage, and apoptosis in young healthy sedentary males after acute high-intensity exercise. Method: Fifteen subjects exercised on bicycle ergometers for 1 h at 75% of their VO(2max). Venous blood samples were taken before exercise (PRE) and hourly after exercise until 4 h (P0-P4). Lymphocyte counts, oxidative DNA damage evaluated using the Comet assay with human 8-oxoguanine DNA glycosylase, and serum lipid peroxide (LPO) concentration were measured. Furthermore, lymphocyte superoxide, Fas receptor (CD95), and Annexin-V-positive lymphocyte apoptosis cells were measured in 10 subjects who exercised and gave blood samples as described above. Results: Lymphocyte counts became significantly lower than the PRE value (P &lt; 0.05): 20.4% at P 1, 24.3% at P2, and 16.3% at P3. Moreover, LPO significantly increased by P2 (P &lt; 0.05): 1.6-fold. The % DNA in tail, indicating oxidative DNA damage, was significantly higher at P3 (54.3 +/- 12.8%) than at PRE (42.6 +/- 11.1 %, P &lt; 0.05). The lymphocyte superoxide level was significantly higher (51.3%) than the PRE value (P &lt; 0.05). Neither CD95 nor Annexin-V-positive cells were significantly different than the PRE value. Conclusion: Results of this study suggest that lymphocyte oxidative DNA damage can relate to lymphocytopenia, although DNA damage was not associated with apoptosis in healthy young sedentary mates.

    DOI

  • Effects of aerobic exercises on arterial calcification and endothelial dysfunction in ovariectomized rats

    Jong Hoon Park, Motoyuki Iemitsu, Seiji Maeda, Ayako Kitajima, Toshiya Nosaka, Naomi Omi

    JOURNAL OF AGING AND PHYSICAL ACTIVITY   16 ( Suppl. S ) S132 - S132  2008年07月  [査読有り]

  • Effects of ACTN3 R577X polymorphism on static torque of knee extensor muscles and leg extension power in postmenopausal women

    Hirofumi Zempo, Kai Tanabe, Haruka Murakami, Motoyuki Iemitsu, Seiji Maeda, Tetsuo Fukunaga, Shinya Kuno

    JOURNAL OF AGING AND PHYSICAL ACTIVITY   16 ( Suppl. S ) S196 - S196  2008年07月

  • Weight loss improves arterial distensibility and endothelial function in obese men

    Asako Miyaki, Seiji Maeda, Maiko Misono, Yoko Saito, Hiroyuki Sasai, Takayuki Endo, Yoshio Nakata, Kiyoji Tanaka, Ryuichi Ajisaka

    JOURNAL OF AGING AND PHYSICAL ACTIVITY   16 ( Suppl. S ) S213 - S214  2008年07月  [査読有り]

  • The benefit of medium-chain triglyceride therapy on the cardiac function of SHRs is associated with a reversal of metabolic and signaling alterations.

    Motoyuki Iemitsu, Nobutake Shimojo, Seiji Maeda, Yoko Irukayama-Tomobe, Satoshi Sakai, Takeshi Ohkubo, Yukihisa Tanaka, Takashi Miyauchi

    American journal of physiology. Heart and circulatory physiology   295 ( 1 ) H136-44 - 0  2008年07月  [査読有り]  [国際誌]

     概要を見る

    The spontaneously hypertensive rat (SHR) is a model of cardiomyopathy that displays a genetic defect in cardiac fatty acid (FA) translocase/CD36, a plasma membrane long-chain FA transporter. Therapy with medium-chain FAs, which do not require CD36-facilitated transport, has been shown to improve cardiac function and hypertrophy in SHRs despite persistent hypertension. However, little is known about the underlying molecular mechanisms. The aim of this study was to document the impact of medium-chain triglyceride (MCT) therapy in SHRs on the expression level and activity of metabolic enzymes and signaling pathways. Four-week-old male SHRs were administered MCT (SHR-MCT) or long-chain triglyceride (SHR-LCT) for 16 wk. We used Wistar-Kyoto (WKY) rats as controls (WKY-MCT and WKY-LCT). The SHR-MCT group displayed improved cardiac dysfunction [as assessed by left ventricular (LV) end-diastolic pressure and the positive and negative first derivatives of LV pressure/P value], a shift in the beta-myosin heavy chain (MHC)-to-alpha-MHC ratio, and cardiac hypertrophy compared with the SHR-LCT group without an effect on blood pressure. Administration of MCT of SHRs reversed the LCT-induced reduction in the cardiac FA metabolic enzymatic activities of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) and medium-chain acyl-CoA dehydrogenase (MCAD). In the SHR-MCT group, the protein expression and transcriptional regulation of myocardial peroxisome proliferator-activated receptor-alpha, which regulates the transcription of LCHAD and MCAD genes, corresponded to the changes seen in those enzymatic activities. Furthermore, MCT intake caused an inhibition of JNK activation in SHR hearts. Collectively, the observed changes in the myocardial activity of metabolic enzymes and signaling pathways may contribute to the improved cardiac dysfunction and hypertrophy in SHRs following MCT therapy.

    DOI PubMed

  • Systemic arterial compliance, systemic vascular resistance, and effective arterial elastance during exercise in endurance-trained men

    Takeshi Otsuki, Seiji Maeda, Motoyuki Iemitsu, Yoko Saito, Yuko Tanimura, Ryuichi Ajisaka, Takashi Miyauchi

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   295 ( 1 ) R228 - R235  2008年07月  [査読有り]

     概要を見る

    Systemic arterial compliance ( C) and vascular resistance ( R) regulate effective arterial elastance ( Ea), an index of artery load. Increases in Ea during exercise are due primarily to reductions of C and maintain optimal ventricular-arterial coupling. Because C at rest and left ventricular functional reserve are greater in endurance-trained ( ET) compared with sedentary control (SC) humans, we hypothesized that reductions of C and increases in Ea are greater in ET than SC individuals. The aim of this study was to investigate C, R, and Ea during exercise in ET and SC humans. C, R, Ea, and cardiac cycle length ( T) were measured at rest and during exercise of 40, 60, and 80% maximal oxygen uptake using Doppler ultrasonography in 12 SC and 13 ET men. C decreased in an exercise intensity-dependent manner in both groups, but its reductions were greater in the ET than SC subjects. Consequently, although C at rest was greater in the ET than SC group, the intergroup difference in C disappeared during exercise. Exercise-related changes in R/T were relatively slight and R/T was lower in the ET than the SC group, both at rest and during exercise. Although Ea at rest was lower in the ET than SC group, there were no intergroup differences in Ea at 40, 60, or 80% maximal oxygen uptake. We conclude that the reductions of C from rest to exercise are more marked in ET than SC humans. This may be related to the exercise-associated disappearance of the difference in Ea between ET and SC humans.

    DOI

  • エストロゲン受容体α遺伝子多型が閉経後女性の動脈硬化指数に及ぼす影響(第10回日本体力医学会北海道地方会)

    林, 貢一郎, 前田, 清司, 家光, 素行, 大槻, 毅, 宮内, 卓, 松田, 光生, 菅原, 順, 田辺, 匠, 久野, 譜也, 鯵坂, 隆一

    体力科學   57 ( 3 ) 419  2008年06月

  • Voluntary running exercise attenuates the progression of endothelial dysfunction and arterial calcification in ovariectomized rats

    J. -H. Park, M. Iemitsu, S. Maeda, A. Kitajima, T. Nosaka, N. Omi

    ACTA PHYSIOLOGICA   193 ( 1 ) 47 - 55  2008年05月  [査読有り]

     概要を見る

    Aim: Loss of oestrogen synthesis capacity after menopause contributes to increases in arterial stiffness and calcification. Exercise training improves arterial stiffness and calcification. However, the mechanism of exercise training-induced improvement of arterial stiffness and calcification remains unclear.
    Method: We examined the mechanism by using aortas of sham-operated rats (sham control; SC), ovariectomized rats (OVX control; OC), OVX plus treatment with vitamin D-3 plus nicotine (VDN) rats (OV sedentary; OVSe), which is an animal model of endothelial dysfunction and arterial calcification, and voluntary running wheel exercise for 8 weeks plus OVX plus VDN rats (OV exercise; OVEx).
    Results: The arterial tissue calcium and endothelin-1 (ET-1: a vasoconstrictor peptide and a potent regulator of arterial calcification) levels were significantly higher in OVSe rats compared with the SC and OC rats, whereas these levels in the OVEx rats were significantly lower than in the OVSe rats. Additionally, arterial expression of endothelial nitric oxide synthase (eNOS), which is an enzyme that produces nitric oxide (NO: a vasodilator substance), was reduced in OVSe rats. However, exercise training prevented the decrease in eNOS expression. Moreover, there was a significant positive correlation between arterial calcium level and arterial ET-1 level.
    Conclusion: These findings suggest that exercise training-induced improvement of ET-1 and NO prevents the impairment of endothelial function after menopause in females, and this improvement may result in less arterial calcification.

    DOI

  • Arterial stiffness, physical activity, and atrial natriuretic peptide gene polymorphism in older subjects

    Motoyuki Iemitsu, Seiji Maeda, Takeshi Otsuki, Jun Sugawara, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda

    HYPERTENSION RESEARCH   31 ( 4 ) 767 - 774  2008年04月  [査読有り]

     概要を見る

    An increase in arterial stiffness with advancing age is associated with several pathological states, including hypertension and arteriosclerosis. Regular exercise improves the aging-induced increase in arterial stiffness and has a protective effect against these diseases. However, not all individuals respond to exercise to the same extent. Atrial natriuretic peptide (ANP) is involved in the regulation of basal blood pressure, blood flow, and vascular tone. The present study was designed to clarify whether gene polymorphisms in ANP-related genes affect exercise-induced improvements in arterial stiffness. We performed a cross-sectional study of 291 healthy middle-aged and older Japanese subjects (63 +/- 1 years), examining the relationship between daily physical activity-induced improvements in arterial stiffness, estimated by brachial-ankle arterial pulse wave velocity (baPWV), and the gene polymorphisms of valine32methionine (V32M: 664G&gt;A) in exon 1 of ANP and asparagine521 aspartic acid (N521 D: 1780A&gt;G) in exon 8 of the ANP clearance receptor (NPR-C). The baseline baPWV was significantly lower in the active group, but no differences were seen in blood pressure. Active subjects with the ANP-VV genotype had significantly lower baPWV and higher plasma ANP levels compared with inactive subjects, but there were no variations related to the VM+MM genotype. Additionally, baPWV and plasma ANP levels were negatively correlated in ANP-VV genotype subjects, but were not correlated in VM+MM individuals. Our results suggest that ANP polymorphism in older Japanese subjects may affect the cardiovascular response to regular exercise.

  • Gender differences in brachial blood flow during fatiguing intermittent handgrip

    Yoko Saito, Motoyuki Iemitsu, Takeshi Otsuki, Seiji Maeda, Ryuichi Ajisaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   40 ( 4 ) 684 - 690  2008年04月  [査読有り]

     概要を見る

    Purpose: Females have been reported to have greater resistance to skeletal muscle fatigue than males. Blood flow, which plays an important role in supplying oxygen and nutrients to working muscles, may play an important role in the mechanisms of gender difference. We hypothesized that females would have greater conduit artery blood flow supplying working muscles than males during intermittent maximal handgrip exercise. Methods: Healthy adult (22-31 yr old) males (N = 8) and females (N = 8), lying in a supine position, repeated static maximal voluntary contractions (MVC) with a handgrip device in an intermittent pattern. Mean brachial arterial blood flow (MBABF) was continuously monitored using Doppler ultrasonography during the 5-s muscle-relaxation phase, when intramuscular pressure does not impede measurement of muscle blood flow during the 4-min exercise period, and continuously during the 10-min recovery period. Vascular conductance (VC) was calculated from the MBABF normalized by forearm volume and mean blood pressure (MBP). Results: Females achieved higher relative muscle force (%MVC) than males throughout both the exercise and the recovery periods (P &lt; 0.05); females tended to exhibit smaller declines in muscle force (i.e., less fatigue). Exercise-induced increases in MBABF normalized to forearm volume were greater in females compared with males during the relaxation phases (P &lt; 0.05), during which females also exhibited greater VC than males (P &lt; 0.05). Conclusion: Our findings suggest that the normalized MBABF and VC in females, who experience less muscle fatigue, are greater during intermittent maximal voluntary handgrip exercise.

    DOI

  • PJ-919 Involvement of HIF-1alpha and beta in Contributory Role of VEGF in Endothelin-1-induced Cardiomyocyte Hypertrophy(Neurohumoral factors(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Shimojo,Nobutake, Jesmin,Subrina, Zaedi,Sohel, Yamaguchi,Naoto, Maeda,Seiji, Miyauchi,Takashi, Aonuma,Kazutaka

    Circulation journal : official journal of the Japanese Circulation Society   72 ( 0 ) 744  2008年03月  [査読有り]

  • Estrogen Pre-treatment Prevents ET-1-induced Cardiomyocyte Hypertrophy through Modulation of VEGF

    Shimojo,Nobutake, Jesmin,Subrina, Zaedi,Shohel, Maeda,Seiji, Miyauchi,Takashi, Aonuma,Kazutaka

    Circulation journal : official journal of the Japanese Circulation Society   72 ( 0 ) 538  2008年03月  [査読有り]

  • Inhibitory Effect of Fluvastatin on Cardiac hypertrophy is Partly Attributed to Interference of JNK and Pin-1 Activation

    Shimojo,Nobutake, Sakai,Satoshi, Maeda,Seiji, Miyauchi,Takashi, Aonuma,Kazutaka

    Circulation journal : official journal of the Japanese Circulation Society   72 ( 0 ) 304  2008年03月  [査読有り]

  • Acute exercise increases systemic arterial compliance after 6-month exercise training in older women

    Seiji Maeda, Takumi Tanabe, Takeshi Otsuki, Jun Sugawara, Ryuichi Ajisaka, Mitsuo Matsuda

    HYPERTENSION RESEARCH   31 ( 2 ) 377 - 381  2008年02月  [査読有り]

     概要を見る

    High physical activity or aerobic exercise training increases central arterial distensibility in older humans. However, the effect of a single bout of exercise on central arterial distensibility in older humans is unknown. Furthermore, the effect of exercise training on central arterial distensibility during exercise is unclear. We investigated whether systemic arterial compliance (SAC) changes after acute exercise in older humans, and, if so, whether this change in SAC is enhanced by aerobic exercise training. Seven untrained older women (61-69 years old) participated in a 6-month exercise intervention study. We measured SAC after acute exercise (cycling exercise at 80% of their individual ventilatory threshold for 30 min) before and after 6 months of aerobic exercise training. After exercise training, the individual ventilatory threshold was significantly increased. In addition, both the SAC at rest and that 30 min after acute exercise were significantly increased after the exercise training program. Before exercise training, there was no significant increase in SAC after acute exercise, whereas, after exercise training, the SAC was significantly increased 30 min after acute exercise. The present study suggests that, after aerobic exercise training, SAC increases after acute exercise in older humans, and that the SAC at rest and after acute exercise is enhanced by aerobic exercise training, thereby causing an effective adaptation in increase in cardiac output during exercise.

  • Estrogen receptor-alpha genotype affects exercise-related reduction of arterial stiffness

    Koichiro Hayashi, Seiji Maeda, Motoyuki Iemitsu, Takeshi Otsuki, Jun Sugawara, Takumi Tanabe, Takashi Miyauch, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   40 ( 2 ) 252 - 257  2008年02月  [査読有り]

     概要を見る

    Purpose: Arterial stiffness, an independent risk factor for cardiovascular disease, increases with advancing age. Arterial stiffness is improved by regular exercise, but individual responses to exercise training are variable. Given that estrogen and estrogen receptor-alpha (ER-alpha) can induce vasodilation and can exert an antiatherosclerotic effect in vessels, we hypothesized that gene polymorphisms of ER-alpha might influence the ability of regular exercise to improve arterial stiffness in postmenopausal women. Methods: One hundred ninety-five healthy postmenopausal women (62 +/- 6 yr, mean +/- SD) participated in our cross-sectional study. We determined the genotype of single-nucleotide polymorphisms (SNP) at -401T/C of intron 1 of the ER-alpha gene. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV), and daily physical activity was estimated by a uniaxial accelerometer. Subjects were divided into active and inactive groups according to the median value (200 kcal.d(-1)) of energy expenditure. Results: baPWV in individuals with the TT variant of -401T/C genotype were significantly higher than for individuals with the TC+CC genotype. No significant differences in mean baPWV values were found between the active group and the inactive group (P = 0.09). A significant reduction of baPWV secondary to increased daily physical activity was observed in individuals with the TC+CC genotype but not in individuals with the TT genotype (TT/active: 1470 +/- 36 cm.s(-1); TT/inactive: 1457 +/- 34 cm.s(-1); TC+CC/active: 1359 +/- 21 cm.s(-1); TC+CC/inactive: 1433 +/- 24 cm.s(-1)). Conclusion: These results suggest that ER-alpha polymorphism affects the regular exercise-related reduction in arterial stiffness in healthy postmenopausal women.

    DOI

  • Comments on Point: Counterpoint: Exercise training does/does not induce vascular adaptations beyond the active muscle beds

    Atsuko, Kagaya, Mutsuko, Yoshizawa, Seiji, Maeda, Hirofumi, Tanaka

    Journal of Applied physiology   105   1008-1010  2008年01月  [査読有り]

  • Estrogen pre-treatment prevents ET-1-induced cardiomyocyte hypertrophy through modulation of VEGF. Proceeding of the 72nd Annual Scientific Meeting of the Japanese Circulation Society

    Shimojo, N, Jesmin, S, Zaedi, S, Maeda, S, Miyauchi, T, Aonuma, K

    Circulation Journal   72   304 - 304  2008年  [査読有り]

  • Cardioprotective effect of eicosapentaenoic acid, important fish oil, through suppression of endothelin-1-induced cardiomyocyte hypertrophy via PPAR-alpha. Proceeding of the 72nd Annual Scientific Meeting of the Japanese Circulation Society

    Shimojo, N, Jesmin, S, Zaedi, S, Maeda, S, Miyauchi, T, Aonuma, K

    Circulation Journal   72   740  2008年  [査読有り]

  • Involvement of HIF-1alpha and beta in contributory role of VEGF in endothelin-1-induced cardiomyocyte hypertrophy.Proceeding of the 72nd Annual Scientific Meeting of the Japanese Circulation Society

    Shimojo, N, Jesmin, S, Zaedi, S, Yamaguchi, N, Maeda, S, Miyauchi, T, Aonuma, K

    Circulation Journal   72   744  2008年  [査読有り]

  • Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats

    Katsuji Aizawa, Motoyuki Iemitsu, Takeshi Otsuki, Seiji Maeda, Takashi Miyauchi, Noboru Mesaki

    JOURNAL OF APPLIED PHYSIOLOGY   104 ( 1 ) 67 - 74  2008年01月  [査読有り]

     概要を見る

    Sex steroid hormones, such as testosterone and estradiol, play important roles in developing both strength and mass of skeletal muscle. Recently, we demonstrated that skeletal muscle can synthesize sex steroid hormones. Whether there are sex differences in basal steroidogenesis or acute exercise-induced alterations of steroidogenesis in the skeletal muscle is unknown. We examined sex differences in the levels of testosterone, estradiol, and steroidogenesis-related enzymes, such as 17 beta-hydroxysteroid dehydrogenase (HSD), 3 beta-HSD, and aromatase cytochrome P-450 (P450arom), in the skeletal muscle at rest and after exercise. We studied the gastrocnemius muscles of resting rats (10 wk old) and exercised rats (10 wk old, treadmill running, 30 m/min, 30 min). Basal muscular testosterone levels were higher in males than females, whereas estradiol did not differ between sexes. Additionally, 17 beta-HSD, 3 beta-HSD, and P450arom transcript and protein expression were greater in females. After acute exercise, testosterone levels and 17 beta-HSD expression increased in muscle in both sexes. By comparison, muscular estradiol levels increased in males following exercise but were unchanged in females. Expression of P450arom, which regulates estrogen synthesis, increased after acute exercise in males but decreased after exercise in females. Thus a single bout of exercise can influence the steroidogenic system in skeletal muscle, and these alterations differ between sexes. The acute exercise-induced alteration of steroidogenic enzymes may enhance the local steroidogenesis in the skeletal muscle in both sexes.

    DOI

  • Relationship between arterial calcification and bone loss in a new combined model rat by ovariectomy and vitamin D3 plus nicotine

    Jong-Hoon, Park, Naomi, Omi, Motoyuki, Iemitsu, Seiji, Maeda, Ayako, Kitajima, Toshiya, Nosaka, Ikuko, Ezawa

    Calcified Tissue International   83   192-201  2008年01月  [査読有り]

  • Agreement between carotid and radial augmentation index: Does medication status affect the relation?

    Jun, Sugawara, Hidehiko, Komine, Koichiro, Hayashi, Mutsuko, Yoshizawa, Takashi, Yokoi, Seiji, Maeda, Hirofumi, Tanaka

    Artery Research   2   74-76  2008年01月  [査読有り]

  • 英文原著論文紹介:エストロゲン受容体α遺伝子多型が動脈スティフネスに及ぼす影響とその性差

    林貢一郎, 前田清司, 家光素行, 大槻毅, 菅原順, 田辺匠, 宮内卓, 久野譜也, 鰺坂隆一, 松田光生

    Arterial Stiffness   13   60-61  2008年01月

  • 英文原著論文紹介:撓骨動脈圧波形から得られるAugmentation Indexは中心動脈のAugmentation Indexに代わりうるか?

    菅原順, 小峰秀彦, 林貢一郎, 前田清司, 松田光生

    Arterial Stiffness   13   58-59  2008年01月

  • 運動強度依存性の筋血流増加にNOは関与するか?

    斉藤 陽子, 前田 清司, 小峰 秀彦, 吉澤 睦子, 中村 真理子, 鰺坂 隆一

    体力科学   56 ( 6 ) 643 - 643  2007年12月

  • Influence of adiponectin gene polymorphism SNP276 (G/T) on adiponectin in response to exercise training

    Hu Huang, Kaoruko Tada Iida, Haruka Murakami, Yoko Saito, Takeshi Otsuki, Motoyuki Iemitsu, Seiji Maeda, Hirohito Sone, Shinya Kuno, Ryuichi Ajisaka

    ENDOCRINE JOURNAL   54 ( 6 ) 879 - 886  2007年12月  [査読有り]

     概要を見る

    Adiponectin is an adipocytokine that is involved in insulin sensitivity. The adiponectin gene contains a single nucleotide polymorphism (SNP) at position 276 (G/T). The GG genotype of SNP276 (G/T) is associated with lower plasma adiponectin levels and a higher insulin resistance index. Therefore, we examined the influence of SNP276 (G/T) on the plasma level of adiponectin in response to exercise training. Thirty healthy Japanese (M12/F18; 56 to 79 years old) performed both resistance and endurance training, 5 times a week for 6 months. The work rate per kg of weight at double-product break-point (DPBP) was measured. Blood samples were obtained before and after the experiment. Plasma concentrations of adiponectin, HbA1c, insulin, glucose, total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, and triglyceride were measured. Genotypes of SNP276 were specified. Student's t-test for paired values and unpaired values was used. After the 6-month training period, the work rate per kg of weight at DPBP and the plasma HDL-cholesterol level were significantly improved (P&lt;0.05), while no change was observed in the total plasma adiponectin level. However, the plasma adiponectin level in those with the GT + TT genotype had significantly increased (P&lt;0.05). Additionally, the degree of the decrease in the HOMA-R level was significantly greater in the subjects with the GT + TT genotype than those with the GG genotype (p&lt;0.05). Our results suggest that subjects with the genotype GT + TT at SNP276 (G/T) have a greater adiponectin-related response to exercise training than those with the GG genotype.

  • アクチニン3遺伝子多型が中高齢女性における大腿筋横断面積に及ぼす影響 : SATプロジェクト193(遺伝子,第62回日本体力医学会大会)

    膳法, 浩史, 田辺, 解, 村上, 晴香, 家光, 素行, 前田, 清司, 福永, 哲夫, 久野, 譜也

    体力科學   56 ( 6 ) 825  2007年12月

  • メタボリックシンドローム予防のためのライフスタイル型運動プログラムが中年勤労者の筋因子に及ぼす影響(生活・健康,第62回日本体力医学大会)

    田辺, 解, 横山, 典子, 膳法, 浩史, 坂戸, 洋子, 大塚, 貞明, 前田, 清司, 家光, 素行, 久野, 譜也

    体力科學   56 ( 6 ) 796  2007年12月

  • メタボリックシンドローム予防を目的としたライフスタイル型運動プログラムが中年勤労男性における精神健康度に及ぼす影響(生活・健康,第62回日本体力医学大会)

    横山, 典子, 田辺, 解, 大塚, 貞明, 前田, 清司, 久野, 譜也

    体力科學   56 ( 6 ) 790  2007年12月

  • 筋力トレーニング強度の違いが中年女性の精神的要素に及ぼす効果(トレーニング,第62回日本体力医学大会)

    前田, 有美, 田辺, 解, 横山, 典子, 膳法, 浩史, 大槻, 毅, 前田, 清司, 久野, 譜也

    体力科學   56 ( 6 ) 747  2007年12月

  • 136. 運動トレーニングによる中心動脈伸展性の増大にエンドセリンが関与する(呼吸・循環,第62回日本体力医学会大会)

    前田, 清司, 菅原, 順, 吉澤, 睦子, 大槻, 毅, 小峰, 秀彦, 林, 貢一郎, 家光, 素行, 横井, 孝志, 鰺坂, 隆一, 宮内, 卓

    体力科學   56 ( 6 ) 646  2007年12月

  • メタボリックシンドロームにおけるライフスタイル型運動プログラムは動脈stiffnessとアディポサイトカインを改善する(呼吸・循環,第62回日本体力医学会大会)

    家光, 素行, 前田, 清司, 田辺, 解, 大槻, 毅, 横山, 典子, 久野, 譜也

    体力科學   56 ( 6 ) 644  2007年12月

  • Antagonism of endothelin action normalizes altered levels of VEGF and its signaling in the brain of stroke-prone spontaneously hypertensive rat

    Subrina Jesmin, Seiji Maeda, Chishimba N. Mowa, Sohel Zaedi, Hiroko Togashi, Shamsul H. Prodhan, Taku Yamaguchi, Mitsuhiro Yoshioka, Ichiro Sakuma, Takashi Miyauchi, Norihiro Kato

    EUROPEAN JOURNAL OF PHARMACOLOGY   574 ( 2-3 ) 158 - 171  2007年11月  [査読有り]

     概要を見る

    Stroke-prone spontaneously hypertensive rats (SHRSP) often suffer from spontaneous stroke, in part, due to abnormalities in the cerebrovasculature. Here, we investigate the profile of key angiogenic factors and their basic signaling molecules in the brain of SHRSP during the age-dependent stages of hypertension. The profile of VEGF and its receptor, Flk-1, was dependent on age and stage of hypertension (i.e., down regulated at pre-hypertensive and malignant hypertensive stages, but up regulated at typical hypertensive stage), while that of its downstream components, pAkt and eNOS, were down regulated in a time-dependent manner in the frontal cortex of SHRSP compared to age-matched genetic control, normotensive WKY rats. On the other hand, the expression of endothelin-1 and its type A receptor (endothelin ETA receptor) were up regulated, depending on age and stage of hypertension. In contrast, levels of endothelin type B receptor were down regulated. The regional cerebral blood flow decreased during the development of malignant hypertension. Thus, subsequent experiments were designed to investigate whether endothelin-1 receptor antagonism, using endothelin-A/-B dual receptor antagonist SB209670, could normalize the molecular profile of these factors in SHRSP brain. Interestingly, blockage of endothelin-1 receptor restored to normal, levels of cerebral endothelin-1, endothelin ETA receptor and endothelin ETB receptor; VEGF and Flk-l; endothelial nitric oxide synthase (eNOS) and pAkt, in SHRSP, compared to age-matched WKY. Endothelin receptor blocker might be important to prevent the progression in the defect in VEGF and its angiogenic signaling cascade in the pathogenesis of hypertension-induced vascular remodeling in frontal cortex of SHRSP rats. (c) 2007 Elsevier B.V All rights reserved.

    DOI

  • Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy: Involvement of hyopoxia inducible factor

    Nobutake Shimojo, Subrina Jesmin, Yuichi Hattori, Seiji Maeda, Takashi Miyauchi, Kazutaka Aonuma

    CIRCULATION   116 ( 16 ) 184 - 184  2007年10月  [査読有り]

  • Exercise training prevents aging-induced cardiomyocyte loss via apoptotic signaling activation in the heart

    Motoyuki Lemitsu, Seiji Maeda, Motohiko Miyachi, Takashi Miyauchi

    CIRCULATION   116 ( 16 ) 802 - 802  2007年10月

  • Prognostic simple test of short memory and physical function in aged 80 and older outpatients

    Nobutake Shini, Subrina Jesmin, Masaaki Soma, Seiji Maeda, Takashi Miyauchi, Kazutaka Aonuma

    CIRCULATION   116 ( 16 ) 830 - 831  2007年10月

  • Cardioprotective effect of eicosapentaenoic acid, an important fish oil, through suppression of endothelin-1-induced cardiomyocyte hypertrophy via PPAR-alpha

    Nobutake Shimogo, Subrina Jesmin, Masaaki Soma, Seiji Maeda, Takashi Miyauchi, Kazutaka Aonuma

    CIRCULATION   116 ( 16 ) 831 - 831  2007年10月  [査読有り]

  • Relationship between arterial stiffness and athletic training programs in young adult men

    Takeshi Otsuki, Seiji Maeda, Motoyuki Iernitsu, Yoko Saito, Yuko Tanimura, Ryuichi Ajisaka, Takashi Miyauchi

    AMERICAN JOURNAL OF HYPERTENSION   20 ( 9 ) 967 - 973  2007年09月  [査読有り]

     概要を見る

    Background: We examined the relationships of endurance and strength exercise training and the adolescent duration of training to arterial stiffness in young adult men. We hypothesized that young adults participating in endurance sports would have decreased arterial stiffness, whereas those in strength-based sports would have increased arterial stiffness. In addition, we predicted that these trends would be more pronounced with an increase in the duration of sport participation.
    Methods: Subjects were male endurance-trained men with short (current age, 20 years; age at beginning of competitive sport, 15 years; sport careers, 5 years; n = 7, S-ET) and long (current age, 20 years; age at beginning of competitive sport, 12 years; sport careers, 8 years; n = 7, L-ET) competitive sport careers, strength-trained men with short (current age, 20 years; age at beginning of competitive sport, 16 years; sport careers, 4 years; n = 7, S-ST) and long (current age, 22 years; age at beginning of competitive sport, 15 years; sport careers, 7 years; n = 7, L-ST) careers, and sedentary control men (aged, 20 years; n = 7, C).
    Results: The exercise training was associated with aortic pulse wave velocity (PWV), a traditional index of arterial stiffness, and the associations were statistically independent of blood pressure (BP). Aortic PWV was lower in L-ET than C and ST. Aortic PWV in L-ST was greater than that of C. The associations of exercise training with systemic arterial compliance (SAC), which inversely correlates with arterial stiffness, were also positive and BP independent. The SAC was greater in the ET groups compared with C and ST groups. The SAC in L-ST was lower than in C.
    Conclusions: These results suggest that changes in arterial stiffness associated with different training programs appear in young adults as well as in older humans, and these changes may begin in adolescence.

    DOI

  • Systemic alpha-adrenergic and nitric oxide inhibition on basal limb blood flow: effects of endurance training in middle-aged and older adults

    Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Takashi Yokoi, Seiji Maeda, Hirofumi Tanaka

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   293 ( 3 ) H1466 - H1472  2007年09月  [査読有り]

     概要を見る

    Endurance training improves endothelium-dependent vasodilation, yet it does not increase basal blood flow in the legs. We determined the effects of a 3-mo aerobic exercise intervention on basal leg blood flow and alpha-adrenergic vasoconstriction and nitric oxide (NO) release in seven apparently healthy middle-aged and older adults (60 +/- 3 yr). Basal femoral artery blood flow (via Doppler ultrasound) (pretraining: 354 +/- 29; posttraining: 335 +/- 34 ml/min) and vascular conductance did not change significantly with the exercise training. Before the exercise intervention, femoral artery blood flow increased 32 +/- 16% with systemic alpha-adrenergic blockade (with phentolamine) (P &lt; 0.05), and the addition of nitric oxide synthase (NOS) inhibition using N-G-monomethyl-L-arginine (L-NMMA) did not affect femoral artery blood flow. After training was completed, femoral artery blood flow increased 47 +/- 7% with alpha-adrenergic blockade (P &lt; 0.01) and then decreased 18 +/- 7% with the subsequent administration of L-NMMA (P &lt; 0.05). Leg vascular conductance showed a greater alpha-adrenergic blockade-induced vasodilation (+ 1.7 +/- 0.5 to + 3.0 +/- 0.5 units, P &lt; 0.05) as well as NOS inhibition-induced vasoconstriction (-0.8 +/- 0.4 to -2.7 +/- 0.7 units, P &lt; 0.05) after the exercise intervention. Resting plasma norepinephrine concentration significantly increased after the training. These results suggest that regular aerobic exercise training enhances NO bioavailability in middle-aged and older adults and that basal limb blood flow does not change with exercise training because of the contrasting influences of sympathetic nervous system activity and endothelium-derived vasodilation on the vasculature.

    DOI

  • 04-7-K202-17 中高齢者に対する筋力トレーニングの下肢静脈コンプライアンスに対する効果(04.運動生理学,一般研究発表抄録)

    鰺坂, 隆一, 前田, 清司, 久野, 譜也

    日本体育学会大会予稿集   0 ( 58 ) 197  2007年09月

  • 04-7-K202-16 中高齢者の運動習慣と動脈stiffnessの関係にナトリウム利尿ペプチド遺伝子多型が及ぼす影響(04.運動生理学,一般研究発表抄録)

    家光, 素行, 前田, 清司, 大槻, 毅, 宮地, 元彦, 久野, 譜也, 鰺坂, 隆一, 松田, 光生

    日本体育学会大会予稿集   0 ( 58 ) 197  2007年09月

  • 04-7-K202-4 ライフスタイル型運動プログラムが中年勤労者のメタボリックシンドロームに及ぼす影響(04.運動生理学,一般研究発表抄録)

    田辺, 解, 横山, 典子, 前田, 清司, 家光, 素行, 坂戸, 洋子, 難波, 秀行, 膳法, 浩史, 久野, 譜也

    日本体育学会大会予稿集   0 ( 58 ) 193  2007年09月

  • Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy

    Nobutake Shimojo, Subrina Jesmin, Sohel Zaedi, Takeshi Otsuki, Seiji Maeda, Naoto Yamaguchi, Kazutaka Aonuma, Yuichi Hattori, Takashi Miyauchi

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   293 ( 1 ) H474 - H481  2007年07月  [査読有り]

     概要を見る

    Although endothelin-1 (ET-1) stimulates vascular endothelial growth factor (VEGF) expression in a variety of cells, including endothelial cells and vascular smooth muscle cells, the effects of ET-1 on expression of VEGF and its receptors in cardiomyocytes are unknown. In the present study, we found that treatment of neonatal rat cardiomyocytes with ET-1 for 24 h resulted in upregulation of VEGF and its two principal receptors, fetal liver kinase 1 and fms-like tyrosine kinase 1, in a concentration-dependent manner (10(-12) to 10(-6) M). ET-1 treatment also caused significant cardiomyocyte hypertrophy, as indicated by increases in cell surface area and [C-14] leucine uptake by cardiomyocytes. Treatment with TA-0201 (10(-6) M), an ETA-selective blocker, eliminated ET-1-induced overexpression of VEGF and its receptors as well as cardiomyocyte hypertrophy. Treatment with VEGF neutralizing peptides (5-10 mu g/ ml) partially but significantly inhibited ET-1-induced cardiomyocyte hypertrophy. These results suggest that ET-1 treatment of cardiomyocytes promotes overexpression of VEGF and its receptors via activation of ETA receptors, and consequently the upregulated VEGF signaling system appears to contribute, at least in part, to ET-1-induced cardiomyocyte hypertrophy.

    DOI

  • Sex differences in the relationship between estrogen receptor alpha gene polymorphisms and arterial stiffness in older humans

    Koichiro Hayashi, Seiji Maeda, Motoyuki Iemitsu, Takeshi Otsuki, Jun Sugawara, Takumi Tanabe, Takashi Miyauchi, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda

    AMERICAN JOURNAL OF HYPERTENSION   20 ( 6 ) 650 - 656  2007年06月  [査読有り]

     概要を見る

    Background: Increased arterial stiffness is an independent risk factor for cardiovascular disease. The estrogen system (estrogen and estrogen receptor-alpha [ER-alpha]) has potent vasodilator and antiatherosclerotic activity in vascular tissue and therefore was implicated in the regulation of arterial stiffness. We hypothesized that the relationship between arterial stiffness and gene polymorphisms in ER-alpha has a sex-specific component in older humans.
    Methods: Two hundred healthy older subjects, comprised of 85 men and 115 postmenopausal women (men, 66 +/- 5 years old; women, 64 +/- 7 years old; mean +/- SD) participated in a cross-sectional study. We determined the genotypes of single-nucleotide polymorphisms (SNPs) at -401T/C of intron 1 and at 30T/C of exon 1 of ER-alpha, using a TaqMan-polymerase chain reaction method. Arterial stiffness was estimated by brachial-ankle pulse-wave velocity (baPWV).
    Results: Polymorphisms of both -401T/C and 30T/C in ER-alpha affected baPWV values in postmenopausal women but did not affect men. The baPWV in women was significantly lower in the CC genotype at both -401T/C and 30T/C than in the TT genotype (both P &lt; .05), and the CC genotype of two SNPs in women was significantly lower than in men.
    Conclusions: The present study suggests that the relationship between arterial stiffness and -401T/C or 30T/C polymorphisms in ER-alpha is different between sexes in older humans. These polymorphisms may be important in the health and clinical care of cardiovascular function and disease in older women.

    DOI

  • Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans

    Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takashi Yokoi, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Seiji Maeda, Hirofumi Tanaka

    HYPERTENSION RESEARCH   30 ( 5 ) 411 - 415  2007年05月  [査読有り]

     概要を見る

    Stiffening of large elastic arteries impairs the buffering function of the arterial system and contributes to cardiovascular disease. The aim of this study was to determine whether endothelium-derived nitric oxide (NO) modulates the stiffness of large elastic arteries in humans. Seven apparently healthy adults (60 +/- 3 years, 2 males and 5 females) underwent systemic a-adrenergic blockade (phentolamine) and systemic NO synthase inhibition using N-G-Monomethyl-L-arginine (L-NMMA) in sequence. Phentolamine was given first to isolate contribution of NO to arterial stiffness by preventing reflex changes in sympathetic tone that result from systemic NO synthase inhibition, and also to compare arterial stiffness at a similar mean arterial pressure. Mean arterial blood pressure decreased (p&lt;0.05) after phentolamine infusion but returned to baseline levels after L-NMMA infusion. The carotid beta-stiffness index (via simultaneous ultrasound and applanation tonometry on the common carotid artery) did not change after the restraint of systemic alpha-adrenergic nerve activity (9.8 +/- 1.2 vs. 9.1 +/- 1.1 U) but increased (p&lt;0.05) after NO synthase inhibition (12.6 +/- 2.0 U). These results suggest that NO appears to modulate central arterial stiffness in humans.

  • Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts

    Subrina Jesmin, Sohel Zaedi, Nobutake Shimojo, Motoyuki Iemitsu, Koichi Masuzawa, Naoto Yamaguchi, Chishimba N. Mowa, Seiji Maeda, Yuichi Hattori, Takashi Miyauchi

    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM   292 ( 4 ) E1030 - E1040  2007年04月  [査読有り]

     概要を見る

    Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts. Am J Physiol Endocrinol Metab 292: E1030-E1040, 2007. First published December 5, 2006; doi:10.1152/ajpendo.00517.2006. - Abnormal alterations in cardiac expression of vascular endothelial growth factor (VEGF) as well as its receptors and impairment in the development of coronary collaterals have recently been reported in diabetic subjects. However, the presence of pharmacological intervention on these defects in diabetes remains unsettled. Here, we studied the effect of endothelin (ET) receptor blockade on cardiac VEGF signaling pathways and cardiac function in Sprague-Dawley rats 5 wk after induction of type I diabetes with streptozotocin (65 mg/kg ip) in comparison with age-matched control rats. After streptozotocin (1 wk), some diabetic rats were treated with the ET receptor antagonist SB-209670 (1 mg/day) for 4 wk. VEGF, its receptors, and its angiogenic signaling molecules [phosphorylated Akt and endothelial nitric-oxide synthase (eNOS)] were analyzed by Western blot, ELISA, real-time PCR, and immunohistochemistry, and cardiac function was evaluated by echocardiography. Coronary capillary morphology was assessed by lectin and enzymatic double staining. We found significant decreases in cardiac expression of VEGF, its receptors, phosphorylation of Akt and eNOS, and coronary capillary density in diabetic rats compared with controls. Treatment of diabetic rats with SB-209670 reversed these alterations to the control levels and ameliorated impairment of cardiac function. From a molecular point of view, the present study is the first to indicate the potential usefulness of an ET receptor antagonist in the treatment of cardiac dysfunction in type I diabetes.

    DOI

  • Role of Endothelin in the Impairment Cardiac Function, Cardiac VEGF Signaling and Coronary Collateral Development in Early Diabetic Rats

    Shimojyoh,Nobutake, Maeda,Seiji, Iemitsu,Motoyuki, Sohel,Zaedhi, Jesmin,Subrina, Otsuki,Takeshi, Yamaguchi,Naoto, Aonuma,Kazutaka, Yamaguchi,Iwao, Miyauchi,Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 0 ) 666  2007年03月  [査読有り]

  • Normalization of Cardiac Upregulated Endothelin-1 System in Type 2 Diabetic Rat by A Long-Acting Calcium Channel Blocker at Sub-Depressor Dose

    Shimojo,Nobutake, Maeda,Seiji, Sohel,Zaedhi, Jesmin,Subrina, Iemitsu,Motoyuki, Otsuki,Takeshi, Hattori,Yuichi, Sakuma,Ichiro, Yamaguchi,Naoto, Aonuma,Kazutaka, Yamaguchi,Iwao, Miyauchi,Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 0 ) 666  2007年03月  [査読有り]

  • Endothelin Selective A Receptor Antagonist Recovers Downregulated VEGF, NO and BCL-2 Expression in Penile Tissues in Type 1 Diabetic Rat

    Jesmin,Subrina, Maeda,Seiji, Iemitsu,Motoyuki, Shimojyoh,Nobutake, Sohel,Zaedi, Yamaguchi,Naoto, Otsuki,Takeshi, Aonuma,Kazutaka, Yamaguchi,Iwao, Miyauchi,Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 0 ) 644 - 645  2007年03月  [査読有り]

  • Chronic Treatment with Endothelin Receptor Antagonist Normalizes the Altered Cerebral Capillary Density in the Frontal Cortex of SHR-SP Rats

    Otsuki,Takeshi, Maeda,Seiji, Sohel,Zaedhi, Shimojyoh,Nobutake, Iemitsu,Motoyuki, Togashi,Hiroko, Jesmin,Subrina, Yamaguchi,Naoto, Aonuma,Kazutaka, Yamaguchi,Iwao, Miyauchi,Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 0 ) 615  2007年03月  [査読有り]

  • PJ-556 Estrogen Pre-treatment Prevents the ET-1-induced Cardiomyocyte Hypertrophy in vitro : Potential Linkage with VEGF(Cardiovascular pharmacology, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Shimojo, Nobutake, Jesmin, Subrina, Maeda, Seiji, Iemitsu, Motoyuki, Zaedi, Sohel, Ootsuki, Takeshi, Yamaguchi, Naoto, Aonuma, Kazutaka, Yamaguchi, Iwao, Miyauchi, Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 0 ) 610 - 611  2007年03月

  • VEGF Signaling is Disrupted in the Heart of Mice Lacking Estrogen Receptor

    Iemitsu,Motoyuki, Sohel,Zaedi, Maeda,Seiji, Jesmin,Subrina, Shimojyoh,Nobutake, Otsuki,Takeshi, Yamaguchi,Naoto, Aonuma,Kazutaka, Hattori,Yuichi, Aonuma,Kazutaka, Yamaguchi,Iwao, Miyauchi,Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 0 ) 606  2007年03月  [査読有り]

  • Endothelin Antagonism Greatly Reverses Upregulated Renin-Angiotensin System in the Hypertrophied Heart of SHR-SP

    Iemitsu,Motoyuki, Maeda,Seiji, Jesmin,Subrina, Shimojyoh,Nobutake, Sohel,Zaedi, Otsuki,Takeshi, Togashi,Hiroko, Yamaguchi,Naoto, Aonuma,Kazutaka, Yamaguchi,Iwao, Miyauchi,Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( Suppl.1 ) 551 - 552  2007年03月  [査読有り]

  • MAPK Activation Change to a Single Bout of Exercise in Untrained and Trained Hearts of Rat

    Iemitsu, Motoyuki, Maeda, Seiji, Jesmin, Subrina, Otsuki, Takeshi, Kasuya, Yoshitoshi, Aonuma, Kazutaka, Yamaguchi, Iwao, Miyauchi, Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( Suppl.1 ) 263  2007年03月  [査読有り]

  • OJ-038 Polymorphism in Endothelin-related Genes Affects Exercise-induced Improvements of Arterial Stiffness in the Japanese Older Subjects(Exercise test/Cardiac rehabilitation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Iemitsu, Motoyuki, Maeda, Seiji, Otsuki, Takeshi, Sugawara, Jun, Tanabe, Takumi, Jesmin, Subrina, Kuno, Shinya, Ajisaka, Ryuichi, Miyauchi, Takashi, Matsuda, Mitsuo

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 0 ) 263  2007年03月

  • OE-263 Contributory Role of VEGF Overexpression in Endothelin-1-induced Cardiomyocyte Hypertrophy(Neurohumoral factors-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Shimojo, Nobutake, Jesmin, Subrina, Maeda, Seiji, Iemitsu, Motoyuki, Zaedi, Sohel, Ootsuki, Takeshi, Yamaguchi, Naoto, Aonuma, Kazutaka, Yamaguchi, Iwao, Miyauchi, Takashi

    Circulation journal : official journal of the Japanese Circulation Society   71 ( 0 ) 216 - 217  2007年03月

  • Effect of exercise training on serum high-sensitivity C-reactive protein concentration in healthy middle-aged and elderly subjects

    Ryuichi Ajisaka, Takumi Tanabe, Takeshi Otsuki, Haruka Murakami, Seiji Maeda, Kiyoji Tanaka, Hirohito Sone, Shinya Kuno

    JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE   56 ( 1 ) 179 - 189  2007年02月

     概要を見る

    High-sensitivity C-reactive protein (CRP) is a novel risk factor for coronary artery disease. It is well known that body weight loss is effective in reducing serum CRP concentration : however, the effect of exercise training on serum CRP concentration has not been fully elucidated. The purpose of this study was to examine the effect of a 24-week exercise training program on serum CRP concentration in 169 healthy middle-aged and elderly subjects (65.9 +/- 6.4 years) Each subject Underwent baseline testing (peak oxygen Uptake, daily physical activity, body weight, and serum CRP levels), and repeated these tests on completion of the training program. The subjects were classified into 2 groups based on initial CRP levels : normal &lt; 1.0 mg/L, n=139, and high &gt;= 1.0 mg/L, n = 30. On completion of the program, both daily physical activity and peak oxygen uptake increased significantly (+33.9 +/- 72.4%, p &lt; 0.0001, +5.4 +/- 14.7%, p= 0.014, respectively). However, body weight did not change significantly. In addition, CRP levels of the entire group did not change significantly. However, CRP levels significantly decreased among the high baseline CRP group (from 1.82 +/- 0.81 mg/L to 0.98 +/- 0.59 mg/L, p &lt; 0.0001). it was concluded that serum CRP levels are reduced without body weight loss in response to exercise training in healthy middle-aged and elderly subjects with high initial CRP levels.

  • Vascular endothelium-derived factors and arterial stiffness in strength- and endurance-trained men

    Takeshi Otsuki, Seiji Maeda, Motoyuki Iemitsu, Yoko Saito, Yuko Tanimura, Ryuichi Ajisaka, Takashi Miyauchi

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   292 ( 2 ) H786 - H791  2007年02月  [査読有り]

     概要を見る

    Arterial stiffness is higher in strength-trained humans and lower in endurance-trained humans. However, the mechanisms underlying these different adaptations are unclear. Vascular endothelium-derived factors, such as endothelin-1 ( ET-1) and nitric oxide ( NO), play an important role in the regulation of vascular tonus. We hypothesized that endogenous ET-1 and NO participate in the adaptation of arterial stiffness in different types of exercise training. The purpose of this study was to investigate plasma ET-1 and NO concentrations and arterial stiffness in strength- and endurance-trained men. Young strength-trained athletes ( SA; n = 11), endurance-trained athletes ( EA; n = 12), and sedentary control men ( C; n = 12) participated in this study. Maximal handgrip strength in SA and maximal oxygen uptake in EA were markedly greater than in C. Aortic pulse-wave velocity, which is an established index of arterial stiffness, was higher in SA and lower in EA than in C. Additionally, we measured systemic arterial compliance ( SAC) using carotid artery applanation tonometry and Doppler echocardiography, because arterial stiffness is a primary determinant of the compliance. SAC was lower in SA and higher in EA compared with that in C. Plasma ET-1 concentrations were higher in SA compared with C and EA. We did not find significant differences in plasma NO concentrations ( measured as the stable end product of NO, i.e., nitrite/nitrate). The relationships of plasma ET-1 concentrations to aortic pulse-wave velocity and SAC were linear. These results suggest that differences in endogenous ET-1 may partly participate in the mechanism underlying different adaptations of arterial stiffness in strength- and endurance-trained men.

    DOI

  • Postexercise heart rate recovery accelerates in strength-trained athletes

    Takeshi Otsuki, Seiji Maeda, Motoyuki Iemitsu, Yoko Sait, Yuko Tanimura, Jun Sugawara, Ryuichi Ajisaka, Takashi Miyauchi

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   39 ( 2 ) 365 - 370  2007年02月  [査読有り]

     概要を見る

    The left ventricle morphologically adapts to endurance exercise training (eccentric cardiac remodeling) and strength exercise training (concentric remodeling). In addition, the acceleration of vagally mediated heart rate (HR) recovery after exercise is one of the functional adaptations of the heart in endurance-trained humans. However, the effect of strength training on HR recovery is unclear. Purpose: The purpose of this study was to investigate whether postexercise HR recovery accelerates in strength-trained athletes. Methods: Subjects were young strength-trained athletes (ST; N = 12), endurance-trained athletes (ET; N = 12), and age-matched sedentary control men (C; N = 12). HR and oxygen uptake were measured during submaximal exercise (cycling exercise, 40% maximal oxygen uptake for 8 min) and 30 s after the exercise (the postexercise period). Results: Left ventricular end-diastolic dimension was higher in both types of athletes compared with C, but greater in ET than in ST (C, 4.3 +/- 0.1 cm; ET, 5.0 +/- 0.1 cm; ST, 4.8 +/- 0.1 cm). Left ventricular average wall thickness was greater in ST in comparison with ET, although it was higher in both trained men compared with C (C, 0.85 +/- 0.02 cm; ET, 0.90 +/- 0.02 cm; ST, 1.00 +/- 0.02 cm). The time constant of postexercise HR decay, an index of vagally mediated postexercise HR recovery, was lower in ST and ET compared with C (C, 94.4 +/- 9.2 s; ET, 65.9 +/- 4.3 s; ST, 69.1 +/- 4.0 s). Oxygen pulse was greater in ST and ET than in C (C, 9.4 +/- 0.6 mL per beat; ET, 13.0 +/- 0.9 mL per beat; ST, 12.8 +/- 0.4 mL per beat), and it results in increased oxygen debt for both types of athletes (C, 0.257 +/- 0.024 L; ET, 0.343 +/- 0.030 L; ST, 0.331 +/- 0.017 L). We did not find significant differences in these indices between ST and ET. Conclusions: These results suggest that the HR recovery immediately after exercise is accelerated in both strength- and endurance-trained athletes.

    DOI

  • Relationship between augmentation index obtained from carotid and radial artery pressure waveforms

    Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Seiji Maeda, Mitsuo Matsuda

    JOURNAL OF HYPERTENSION   25 ( 2 ) 375 - 381  2007年02月  [査読有り]

     概要を見る

    Objective Increased aortic and carotid arterial augmentation index (AT) has been directly linked with cardiovascular disease risk, mortality and morbidity. The aim of this study was to examine whether Al obtained directly from radial artery pressure waveforms (radial Al) can provide information comparable with carotid arterial Al measurements.
    Methods In a cross-sectional study of 204 apparently healthy subjects (88 men and 116 women) aged 19-76 years (51 +/- 15 years, mean +/- SD), carotid Al [(second peak carotid systolic pressure-first peak carotid systolic pressure)/carotid pulse pressure*100] and radial Al [(second peak radial systolic pressure-diastolic pressure)/(first peak radial systolic pressure-diastolic pressure)*100] were measured using applanation tonometry.
    Results Radial Al was strongly correlated with carotid Al (r=0.86, P &lt; 0.0001, SD of difference 10.0%), although radial Al was consistently approximately 66% higher than carotid Al. In 16 apparently healthy young adults (11 men and five women, aged 23 +/- 3 years) handgrip exercise was immediately followed by post-exercise muscle ischaemia (PEMI) to compare changes in carotid and radial Al during increased sympathetic nervous activity PEMI caused parallel increases in carotid and radial Al (26 and 19%). Accordingly, changes in radial Al with PEMI were strongly correlated with corresponding changes in carotid Al (r=0.86, P &lt; 0.0001, SD of difference 7.3%).
    Conclusion These results suggest that Al obtained directly from radial arterial pressure waveforms could provide equivalent information to carotid arterial Al, and has potential as a surrogate marker of cardiovascular disease. J Hypertens 25:375-381 (c) 2007 Lippincott Williams & Wilkins.

  • 健常中高齢者における運動トレーニングの血清高感度CRP濃度に対する効果

    鯵坂, 隆一, 田辺, 匠, 大槻, 毅, 村上, 晴香, 前田, 清司, 田中, 喜代次, 曽根, 博仁, 久野, 譜也

    体力科學   56 ( 1 ) 179 - 189  2007年02月  [査読有り]

     概要を見る

    High-sensitivity C-reactive protein (CRP) is a novel risk factor for coronary artery disease. It is well known that body weight loss is effective in reducing serum CRP concentration; however, the effect of exercise training on serum CRP concentration has not been fully elucidated. The purpose of this study was to examine the effect of a 24-week exercise training program on serum CRP concentration in 169 healthy middle-aged and elderly subjects (65.9±6.4 years). Each subject underwent baseline testing (peak oxygen uptake, daily physical activity, body weight, and serum CRP levels), and repeated these tests on completion of the training program. The subjects were classified into 2 groups based on initial CRP levels: normal<1.0mg/L, n=139, and high≧1.0mg/L, n=30. On completion of the program, both daily physical activity and peak oxygen uptake increased significantly (+33.9±72.4%, p<0.0001, +5.4±14.7%, p=0.014, respectively). However, body weight did not change significantly. In addition, CRP levels of the entire group did not change significantly. However, CRP levels significantly decreased amongthe high baseline CRP group (from 1.82±0.81mg/L to 0.98±0.59mg/L, p<0.0001). It wa

  • Contributory Role of VEGF Overexpression in Endothelin-1-induced Cardiomyocyte Hypertrophy. Proceeding of the 71st Annual Scientific Meeting of the Japanese Circulation Society (Original article peer reviewed)

    Shimojo, N, Jesmin, S, Maeda, S, Iemitsu, M, Zaedi, S, Otsuki, T, Yamaguchi, N, Aonuma, K, Yamaguchi, I, Miyauchi, T

    Official Journal of Japanese Circulation Society,Circulation Journal   71   216  2007年  [査読有り]

  • Estrogen Pre-treatment Prevents the ET-1-induced Cardiomyocyte Hypertrophy in vitro: Potential Linkage with VEGF. Proceeding of the 71st Annual Scientific Meeting of the Japanese Circulation Society

    Shimojo, N, Jesmin, S, Maeda, S, Iemitsu, M, Zaedi, S, Otsuki, T, Yamaguchi, N, Aonuma, K, Yamaguchi, I, Miyauchi, T

    Circulation Journal   71   610 - 611  2007年  [査読有り]

  • Estrogen Receptor Alpha and Beta Are Equally Involved in Cerebral Vascular Endothelial Growth Factor/KDR/Nitric Oxide Pathway in Female Mice. Proceeding of the 71st Annual Scientific Meeting of the Japanese Circulation Society

    Jesmin, S, Maeda, S, Zaedi, S, Shimojo, N, Iemitsu, M, Otsuki, T, Yamaguchi, N, Miyauchi, T

    Official Journal of Japanese Circulation Society, Circulation Journal   71   423  2007年  [査読有り]

    DOI

  • Cardioprotective Effect of Eicosapentaenoic Acid, an Important Fish Oil, through Suppression of Endothelin-1-induced Cardiomyocyte Hypertrophy via PPAR-α. Proceeding of American Heart Association's Scientific Sessions 2007

    Shimojo, N, Jesmin, S, Zaedi, S, Maeda, S, Miyauchi, T, Aonuma, K

    Circulation Journal     831 - 831  2007年  [査読有り]

  • Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats

    Katsuji, Aizawa, Motoyuki, Iemitsu, Seiji, Maeda, Subrina, Jesmin, Takeshi, Otsuki, Chishimba, N Mowa, Takashi, Miyauchi, Noboru, Mesaki

    American Journal of Physiology: Endocrinology and Metabolism   292   E577-E584  2007年01月  [査読有り]

  • Post-exercise heart rate recovery accelerates in strength-trained athletes

    Takeshi, Otsuki, Seiji, Maeda, Motoyuki, Iemitsu, Yoko, Saito, Yuko, Tanimura, Jun, Sugawara, Ryuichi, Ajisaka, Takashi, Miyauchi

    Medicine & Science in Sports & Exercise   39   365-370  2007年01月  [査読有り]

  • 生活習慣病と加齢における有酸素性運動トレーニングによるエネルギー代謝の改善に関与する分子メカニズムの検討

    家光素行, 前田清司, 大槻毅, 宮内卓

    筑波大学体育科学系紀要   30   101-104  2007年01月

  • 英文原著論文紹介:加齢に伴う動脈コンプライアンスの低下は最大下運動時の有酸素性能力に関連する

    大槻毅, 前田清司, 菅原順, 気仙有実子, 村上晴香, 田辺匠, 宮内卓, 久野譜也, 鰺坂隆一, 松田光生

    Arterial Stiffness   12   98-99  2007年01月

  • 英文原著論文紹介:中高齢者における動脈stiffnessの運動効果にエンドセリン関連遺伝子多型が影響する

    家光素行, 前田清司, 大槻毅, 菅原順, 田辺匠, Subrina, Jesmin, 久野譜也, 鰺坂隆一, 宮内卓, 松田光生

    Arterial Stiffness   11   82-83  2007年01月

  • 中年勤労男性における精神健康度及び身体活動の習慣化(生活・健康, 第61回 日本体力医学会大会)

    横山, 典子, 前田, 有美, 長谷部, 佳奈子, 田辺, 解, 前田, 清司, 久野, 譜也

    体力科學   55 ( 6 ) 833  2006年12月

  • 中高齢者における38℃浸水が心臓自律神経活動に及ぼす影響(生活・健康, 第61回 日本体力医学会大会)

    野上, 佳恵, 阿保, 純一, 大槻, 毅, 村上, 晴香, 前田, 清司, 久野, 譜也, 鰺坂, 隆一

    体力科學   55 ( 6 ) 826  2006年12月

  • 中年勤労者男性におけるメタボリックシンドローム関連因子と体力の関係(代謝, 第61回 日本体力医学会大会)

    田辺, 解, 横山, 典子, 坂戸, 洋子, 前田, 有美, 前田, 清司, 久野, 譜也

    体力科學   55 ( 6 ) 682  2006年12月

  • 154. 中高齢者による有酸素性運動トレーニングが下肢の交感神経性血管収縮に及ぼす影響(呼吸・循環, 第61回 日本体力医学会大会)

    吉澤, 睦子, 菅原, 順, 小峰, 秀彦, 林, 貢一郎, 横井, 孝志, 大槻, 毅, 下条, 信威, 宮内, 卓, 前田, 清司

    体力科學   55 ( 6 ) 655  2006年12月

  • 123. 動脈コンプライアンスの動脈エラスタンスに対する貢献度は運動時に増大する(呼吸・循環, 第61回 日本体力医学会大会)

    大槻, 毅, 前田, 清司, 家光, 素行, 斉藤, 陽子, 谷村, 祐子, 鯵坂, 隆一, 宮内, 卓

    体力科學   55 ( 6 ) 640  2006年12月

  • 中高齢者における動脈 stiffness の運動効果にエンドセリン関連遺伝子多型が影響する : SATプロジェクト191(呼吸・循環, 第61回 日本体力医学会大会)

    家光, 素行, 前田, 清司, 大槻, 毅, 菅原, 順, 田辺, 匠, 久野, 譜也, 鰺坂, 隆一, 宮内, 卓, 松田, 光生

    体力科學   55 ( 6 ) 639  2006年12月

  • エストロゲン受容体α遺伝子多型は身体活動レベルと動脈 stiffness の関係に影響する : SATプロジェクト192(呼吸・循環, 第61回 日本体力医学会大会)

    林, 貢一郎, 前田, 清司, 家光, 素行, 大槻, 毅, 菅原, 順, 田辺, 匠, 宮内, 卓, 久野, 譜也, 鰺坂, 隆一, 目崎, 登, 松田, 光生

    体力科學   55 ( 6 ) 636  2006年12月

  • 56. 骨格筋は性ホルモンを産生する(運動器, 第61回 日本体力医学会大会)

    相澤, 勝治, 家光, 素行, 前田, 清司, 大槻, 毅, 宮内, 卓, 目崎, 登

    体力科學   55 ( 6 ) 606  2006年12月

  • 2PD7 Gender differences of steroidogenesis-related enzymes expression in skeletal muscle following acute exercise(The Proceeding of the 14th Annual Meeting of Japan Society of Exercise and Sports Physiology July 29-30, (Hiroshima))

    AIZAWA, Katsuji, IEMITSU, Motoyuki, MAEDA, Seiji, OTSUKI, Takeshi, MIYAUCHI, Takashi, MESAKI, Noboru

    Advances in exercise and sports physiology   12 ( 3 ) 120  2006年12月

  • 2AD6 MAPK activation response to an acute bout of exercise in untrained and trained rat hearts(The Proceeding of the 14th Annual Meeting of Japan Society of Exercise and Sports Physiology July 29-30, (Hiroshima))

    IEMITSU, Motoyuki, MAEDA, Seiji, OTSUKI, Takeshi, MIYAUCHI, Takashi

    Advances in exercise and sports physiology   12 ( 3 ) 112  2006年12月

  • The effects of daily physical activity on the age-related carotid arteria stiffening in middle-aged and elderly people

    Jun Sugawara, Takeshi Otsuku, Takumi Tanabe, Koichiro Hayashi, Seiji Maeda, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda

    JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE   55 ( Suppl. S ) 11 - 14  2006年10月  [査読有り]

     概要を見る

    The engaging &gt; 30 minutes of physical activity (PA) at 4-6 METs has been recommended for the prevention of cardiovascular disease. We determined whether relatively low intensity (i.e., 3-5 METs) PA inhibits the age-related central arterial stiffening, a risk of cardiovascular disease. In the cross-sectional study, the association between carotid arterial properties (via ultrasound system) and daily PA (via electric accelerometer) were studied in 172 normotensive people (41-82 yrs). People engaging &gt; 30 min/day of PA corresponding to 3-5 METs had a significantly lower beta-stiffness index than sedentary peers after adjusting for covariates (i.e., age and PA time at more than 6 METs). In the interventional study, beta-stiffness index of nine normotensive postmenopausal women was significantly decreased after the 12-week aerobic training (cycling at 80% of ventiratory threshold, approximate to 4 METs, 30 min/day, 5 days/week). These results suggest that the increase in daily PA at 3-5 METs inhibits the age-related carotid arterial stiffening.

  • Basal gene expression of vascular endothelial growth factor-related transcriptional factors in rat skeletal muscle differs between slow and fast fiber types

    Takeshi Otsuki, Seiji Maeda, Motoyuki Iemitsu, Subrina Jesmin, Takashi Miyauchi

    JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE   55 ( Suppl. S ) 65 - 69  2006年10月  [査読有り]

     概要を見る

    Skeletal muscle is comprised of multiple fiber types. Slow-twitch oxidative muscle fibers have greater capillary density compared with fast-twitch glycolytic fibers of skeletal muscle. To gain insight into the molecular mechanism underlying the difference of capillary density, we investigated whether the basal gene expression of vascular endothelial growth factor (VEGF), a major angiogenesis-related factor, and its transcriptional factors (hypoxia-inducible factor-1 alpha, transforming growth factor-beta 1, c-jun, and c-fos) differs between these two fiber types of rat skeletal muscle. The mRNA expression of VEGF and its transcriptional factors was significantly higher in slow type fiber of muscle (soleus muscle) compared with fast type fiber of muscle (plantaris and tibialis anterior muscles). These results suggest that the difference of basal gene expression of VEGF and its transcriptional factors between slow and fast fiber types of skeletal muscle may partly contribute to the difference in capillary density between these two fiber types.

  • Physical activity duration, intensity, and arterial stiffening in postmenopausal women

    Jun Sugawara, Takeshi Otsuki, Takumi Tanabe, Koichiro Hayashi, Seiji Maeda, Mitsuo Matsuda

    AMERICAN JOURNAL OF HYPERTENSION   19 ( 10 ) 1032 - 1036  2006年10月  [査読有り]

     概要を見る

    Background: Aerobic exercise training is associated with lower central arterial stiffness, but little information exists on the effects of physical activity intensity or duration on central arterial stiffness. Using a cross-sectional and interventional approach, we tested the hypothesis that both moderate and vigorous physical activity reduce central arterial stiffness in postmenopausal women.
    Methods: Carotid arterial stiffness (via ultrasound and applanation tonometry) and duration of physical activity at low, moderate, and vigorous intensities (via electronic accelerometer) were measured in 103 apparently healthy sedentary or recreationally active women 47 to 82 years of age. Moderate intensity physical activity was defined as 4.0 to 6.0 metabolic equivalents (MET) in subjects aged &lt; 65 years and as 3.0 to 5.0 MET in subjects &gt;= 65 years. A subgroup of 17 sedentary subjects was randomly assigned to moderate (n = 8) or vigorous (n = 9) intensity cycling exercise training (900 kcal/week, three to five sessions per week, for 12 weeks). Carotid arterial stiffness was measured before and after training.
    Results: Carotid beta-stiffness index was significantly correlated with the duration of moderate and vigorous intensity physical activity (r = -0.25 and r = -0.22) even after adjustment for age, height, and mean BP. Carotid beta-stiffness index significantly decreased after moderate and vigorous intensity cycling training. There were no significant group differences in the magnitude of beta-stiffness index change even after adjustment for expected confounders (eg, baseline beta-stiffness index, height, body mass index, heart rate, and post-training body mass, body mass index, and mean BP).
    Conclusions: These results suggest that both moderate and vigorous physical activities have favorable effects on central arterial stiffness in postmenopausal women.

    DOI

  • Effects of leg resistance training on arterial function in older men

    S. Maeda, T. Otsuki, M. Iemitsu, M. Kamioka, J. Sugawara, S. Kuno, R. Ajisaka, H. Tanaka

    BRITISH JOURNAL OF SPORTS MEDICINE   40 ( 10 ) 867 - 869  2006年10月  [査読有り]

     概要を見る

    Background: Little information is available on the effect of strength training on vascular function, particularly in older people.
    Objective: To determine the effect of resistance training on arterial stiffness and endothelial function in older adults.
    Method: Eleven healthy men ( mean (SEM) age 64 ( 1) years) performed 12 weeks of resistance training involving knee flexion and extension ( three sets a day, two days a week).
    Results: Resistance training increased maximal muscle power by 16% (p&lt; 0.0001). Arterial stiffness as assessed by aortic pulse wave velocity did not change with resistance training. Plasma concentration of nitric oxide ( NO), measured as its stable end product (nitrite/nitrate), had increased ( p&lt; 0.05) after resistance training (61.2 (10.4) v 39.6 (3.2) mmol/l). There was no change in plasma concentration of endothelin-1.
    Conclusion: The results suggest that short term resistance training may increase NO production without stiffening central arteries in healthy older men.

    DOI

  • Age-related reduction of systemic arterial compliance relates to decreased aerobic capacity during sub-maximal exercise

    Takeshi Otsuki, Seiji Maeda, Jun Sugawara, Yumiko Kesen, Haruka Murakami, Takumi Tanabe, Takashi Miyauchi, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda

    HYPERTENSION RESEARCH   29 ( 10 ) 759 - 765  2006年10月  [査読有り]

     概要を見る

    A decrease in systemic arterial compliance (SAC) increases left ventricular load along with the demand for excessive myocardial oxygen consumption when the age-related reduction of SAC reaches a marked level, and consequently may depress left ventricular pump function. Reduced left ventricular pump function decreases aerobic capacity, and some study groups have shown that SAC and/or central arterial distensibility is correlated with maximal aerobic capacity in humans. We thus hypothesize that, once the age-related reduction of SAC reaches a marked level, the participation of SAC in aerobic capacity will be significant even during sub-maximal exercise. Thirty young humans and 46 elderly humans participated in this study. SAC, oxygen uptake at the ventilatory threshold (Vo(2 VT)), and the ratio of increase in oxygen uptake, in cardiac output, and in effective arterial elastance to increase in work rate (Delta Vo(2)/Delta WR, Delta CO/Delta WR and Delta E-a/Delta WR) were measured. SAC was significantly higher in young subjects compared with elderly subjects, and was significantly related to Vo(2 VT) in elderly subjects. SAC also significantly correlated with Delta Vo2/Delta WR, Delta CO/Delta WR and Delta E-a/Delta WR in elderly subjects. When total subjects were divided by the value of SAC into 6 groups, the Vo(2 VT) values in the 3 groups with lower SAC were significantly lower than those in the 3 groups with higher SAC, and gradually decreased with the reduction of SAC. There were no changes in Vo(2 VT) among the 3 groups with higher SAC. These results suggest that the participation of SAC in aerobic capacity is significant even during sub-maximal exercise in individuals who show a pronounced age-related reduction of SAC.

  • The effects of daily physical activity on the age-related carotid arteria stiffening in middle-aged and elderly people

    Jun Sugawara, Takeshi Otsuku, Takumi Tanabe, Koichiro Hayashi, Seiji Maeda, Shinya Kuno, Ryuichi Ajisaka, Mitsuo Matsuda

    JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE   55 ( 0 ) 11 - 14  2006年10月

     概要を見る

    The engaging &gt; 30 minutes of physical activity (PA) at 4-6 METs has been recommended for the prevention of cardiovascular disease. We determined whether relatively low intensity (i.e., 3-5 METs) PA inhibits the age-related central arterial stiffening, a risk of cardiovascular disease. In the cross-sectional study, the association between carotid arterial properties (via ultrasound system) and daily PA (via electric accelerometer) were studied in 172 normotensive people (41-82 yrs). People engaging &gt; 30 min/day of PA corresponding to 3-5 METs had a significantly lower beta-stiffness index than sedentary peers after adjusting for covariates (i.e., age and PA time at more than 6 METs). In the interventional study, beta-stiffness index of nine normotensive postmenopausal women was significantly decreased after the 12-week aerobic training (cycling at 80% of ventiratory threshold, approximate to 4 METs, 30 min/day, 5 days/week). These results suggest that the increase in daily PA at 3-5 METs inhibits the age-related carotid arterial stiffening.

  • Time-dependent expression of renal vaso-regulatory molecules in LPS-induced endotoxemia in rat

    Naoto Yamaguchi, Subrina Jesmin, Sohel Zaedi, Nobutake Shimojo, Seiji Maeda, Satoshi Gando, Akio Koyama, Takashi Miyauchi

    PEPTIDES   27 ( 9 ) 2258 - 2270  2006年09月  [査読有り]

     概要を見る

    To elucidate roles of microvascular factors in the pathogenesis of renal complications during endotoxemia, that is characterized by renal vasoconstriction and systemic hypotension/generalized non-renal vasodilation, we profile the expression pattern and time-course of three key vaso-regulators, namely endothelin (ET)-1, nitric oxide (NO), and angiotensin II (Ang II). We hypothesize that disruption of the overall balance between vasodilatation and vasoconstriction in the kidney, during the early phase of sepsis, contribute to its (kidney) predisposition to acute renal failure. Adult male Wistar rats were rendered endotoxemic at different time points (1, 3, 6 and 10 h) by a single i.p. injection of lipopolysaccharide (LPS) (15 mg/kg) dissolved in saline. Control group was injected vehicle only (saline). Both systolic and diastolic blood pressures significantly decreased at different time points after LPS administration. Surprisingly, renal histopathological evaluation showed no remarkable changes in LPS-induced endotoxemia. However, overall, levels of the vaso-regulators and, where applicable, their respective receptors were upregulated: (1) plasma ET-1 increased 25-fold and peaked, as renal ET-1 mRNA, at 3 h; renal ET-1 protein and its receptors, ET type A (ETA) receptor (vasoconstrictive) and ET type B (ETB) receptor (vasodilatatory) increased in a time-dependent fashion, (2) Ang II increased by 53% compared to control, peaking at 6 h. However, while levels of Ang II type 1 (AT,) receptor increased over time after LPS injection, those of Ang II type 2 (AT(2)) receptor were downregulated, (3) data of NO system (NO-NOS), the key vasodilator, were the most intriguing. Whereas levels of renal NO increased time-dependently following LPS administration, with a 2240-fold increase in renal iNOS expression, levels of eNOS, were almost unchanged. In conclusion, the present study overall reveals intriguing and complex dynamics between levels of vasoconstrictors and vasodilators during the early phase of LPS-induced endotoxemia. These shifts in molecular expressions are likely triggered by compensatory mechanisms aimed at counteracting the undesirable and dominant effects of one group of vaso-regulatory moiety over the other. (c) 2006 Elsevier Inc. All rights reserved.

    DOI

  • Contribution of systemic arterial compliance and systemic vascular resistance to effective arterial elastance changes during exercise in humans

    T. Otsuki, S. Maeda, M. Iemitsu, Y. Saito, Y. Tanimura, R. Ajisaka, T. Miyauchi

    ACTA PHYSIOLOGICA   188 ( 1 ) 15 - 20  2006年09月  [査読有り]

     概要を見る

    Background: Effective arterial elastance (Ea), an index of arterial load, increases with elevations in left ventricular elastance to maximize the efficiency of left ventricular stroke work during exercise. Systemic arterial compliance (C) and vascular resistance (R) are the primary components contributing to Ea, and R plays a greater role in determining Ea at rest. We hypothesized that the contribution of C to Ea increases during exercise to maintain an optimal balance between arterial load and ventricular elastance, and that the increase in Ea is due primarily to a reduction in C.
    Aim: The aim of this study was to investigate the contributions of C and R to Ea during exercise.
    Methods: Ea (0.9 x systolic blood pressure/stroke volume), C (stroke volume/pulse pressure), R (mean blood pressure/cardiac output), and cardiac cycle length (T) were measured at rest and during exercise of 40%, 60% and 80% maximal oxygen uptake (VO2max) using Doppler echocardiography in 45 healthy men.
    Results: Ea did not differ between rest and 40% VO2max, but it was greater at 60% and 80% VO2max. C markedly decreased during exercise in an exercise intensity-dependent manner. The changes in R/T during exercise were small, whereas it decreased at 40% VO2max and gradually increased at 60% and 80% VO2max.
    Conclusions: The present results suggest that the contribution of systemic arterial compliance to effective arterial elastance increases during exercise. Therefore, we propose that the increase in arterial load during exercise is mainly driven by a reduction in systemic arterial compliance.

    DOI

  • Eicosapentaenoic acid prevents endothelin-1-induced cardiomyocyte hypertrophy in vitro through the suppression of TGF-beta 1 and phosphorylated JNK

    Nobutake Shimojo, Subrina Jesmin, Sohel Zaedi, Seiji Maeda, Masaaki Soma, Kazutaka Aonuma, Iwao Yamaguchi, Takashi Miyauchi

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   291 ( 2 ) H835 - H845  2006年08月  [査読有り]

     概要を見る

    The cardiovascular benefit of fish oil in humans and experimental animals has been reported. Endothelin (ET)-1 is a well-known cardiac hypertrophic factor. However, although many studies link a fish oil extract, eicosapentaenoic acid (EPA), to cardiac protection, the effects of EPA on cardiac hypertrophy and underlying mechanism(s) are unclear. The present study investigated whether EPA prevents ET-1-induced cardiomyocyte hypertrophy; the potential pathways likely to underlie such an effect were also investigated. Cardiomyocytes were isolated from neonatal rat heart, cultured for 3 days, and then treated for 24 h with vehicle only (control), treated with 0.1 nM ET-1 only, or pretreated with 10 mu M EPA and then treated with 0.1 nM ET-1. The cells were harvested, and changes in cell surface area, protein synthesis, expression of a cytoskeletal (alpha-actinin) protein, and cell signaling were analyzed. ET-1 induced a 97% increase in cardiomyocyte surface area, a 72% increase in protein synthesis rate, and an increase in expression of alpha-actinin and signaling molecule [transforming growth factor-beta 1 (TGF-beta 1), c-Jun NH2-terminal kinase (JNK), and c-Jun]. Development of these ET-1-induced cellular changes was attenuated by EPA. Moreover, the hypertrophied cardiomyocytes showed a 1.5- and a 1.7-fold increase in mRNA expression of atrial and brain natriuretic peptides, the classical molecular markers of cardiac hypertrophy, respectively; these changes were also suppressed by EPA. Here we show that ET-1 induces cardiomyocyte hypertrophy and expression of hypertrophic markers, possibly mediated by JNK and TGF-beta 1 signaling pathways. These ET-1-induced effects were blocked by EPA, a major fish oil ingredient, suggesting that fish oil may have beneficial protective effects on cardiac hypertrophy.

    DOI

  • 中高齢者における血清高感度CRP濃度と運動耐容能の関連 : SATプロジェクト188

    鰺坂, 隆一, 大槻, 毅, 前田, 清司, 松田, 光生, 久野, 譜也, 田中, 喜代次, 曽根, 博仁

    日本臨床スポーツ医学会誌 = The journal of Japanese Society of Clinical Sports Medicine   14 ( 3 ) 303 - 310  2006年08月  [査読有り]

  • 04-18-S401-11 近赤外線分光法による持続的定常運動時非運動部血液量動態は皮膚血液量動態を反映する(04 運動生理学,一般研究発表抄録)

    鰺坂, 隆一, 大槻, 毅, 前田, 清司, 久野, 譜也

    日本体育学会大会予稿集   0 ( 57 ) 131  2006年08月

  • 間欠的掌握運動後の筋出力回復動態の性差と筋酸素化動態との関連

    斉藤, 陽子, 大槻, 毅, 家光, 素行, 前田, 清司, 鰺坂, 隆一

    体力科學   55 ( 4 ) 433 - 442  2006年08月  [査読有り]

     概要を見る

    To investigate a relationship between gender differences in recovery from skeletal muscle fatigue and muscle oxygenation, we examined whether there is a difference in oxygen supply and consumption of the working muscles after intermittent handgrip exercise between young males and females using near-infrared spectroscopy (NIRS). Healthy young subjects (25.8±3.9 years; males, n=10; females, n=10) repeated static maximal voluntary contractions (MVC) with a handgrip for 5 seconds followed by 5 seconds rest for a period of 4 minutes in Study 1. The MVC force was measured before, each minute during the handgrip exercise, and 2, 5, and 10 minutes following the exercise. In Study 2, the selected 10 subjects (males, n=5; females, n=5) performed the same exercise and their total- and deoxy- hemoglobin/myoglobin level was measured using the venous occlusion NIRS method; and O_2 supply index (OSI) and O_2 consumption index (OCI) calculated before and after the exercise. In Study 1, females exhibited higher %MVC force at the end of the exercise and during the recovery period than males (p<0.05). In Study 2, the %OSI was significantly lower in females than in males at 5 and 10 minutes in the re

  • Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise

    M Iemitsu, S Maeda, S Jesmin, T Otsuki, Y Kasuya, T Miyauchi

    JOURNAL OF APPLIED PHYSIOLOGY   101 ( 1 ) 151 - 163  2006年07月  [査読有り]

     概要を見る

    Since exercise training causes cardiac hypertrophy and a single bout induces mechanical stress to the heart, the present study aimed to characterize the activation patterns of multiple MAPK signaling pathways in the heart after a single bout of exercise or chronic exercises. The hearts of untrained rats received 5, 15, and 30 min of treadmill running exercise (Ex5 to Ex30) and rested for 0.5, 1, 3, 6, 12, and 24 h (PostEx0.5 to PostEx24) before subjecting them to the following different experiments. Activation of MAPKs (ERK, JNK, and p38) and MAPKKs (MEK1/2, SEK, and MKK3/6) increased immediately after acute exercise in a time-dependent manner, with ERK, JNK, and p38 peaking at Ex15, Ex15, and Ex30, respectively. Expression of immediate early genes (c-fos, c-jun, and c-myc) was augmented and activator protein-1 DNA binding activity was enhanced in untrained rats immediately after a single bout of exercise. The elevated levels of MAPKs declined to the resting levels within 24 h after exercise. In another set of experiments, following 4, 8, and 12 wk of exercise training, the rats exhibited significant cardiac hypertrophy by week 12. Activation of MAPKs in the 4-wk-trained rats increased after a 30-min single bout of exercise but decreased in the 8-wk group. Finally, the activity of MAPKs signaling in the 12-wk-trained rats exposed to an acute bout of exercise was unaltered. We conclude that exercise induces the activation of multiple MAPK (ERK, JNK, and p38) pathways in the heart, an effect that gradually declines with the development of exercise-induced cardiac hypertrophy.

  • Effects of a selective endothelin a receptor antagonist on the expressions of iNOS and eNOS in the heart of early streptozotocin-induced diabetic rats (Original article peer reviewed)

    Jesmin, S, Zaedi, S, Maeda, S, Yamaguchi, I, Goto, K, Miyauchi, T

    Experimental Biology and Medicine   231   925 - 931  2006年06月  [査読有り]

  • Time course alterations of myocardial endothelin-1 production during the formation of exercise training-induced cardiac hypertrophy

    M Iemitsu, S Maeda, T Otsuki, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 871 - 875  2006年06月  [査読有り]

     概要を見る

    Endothelin (ET)-1 is produced by endothelial cells and cardiac myocytes. ET-1 has positive inotropic and chronotropic effects on the heart and causes myocardial cell hypertrophy. Exercise training induces a physiologic cardiac hypertrophy. To study whether myocardial ET-1 is involved in the formation of exercise training-induced cardiac hypertrophy, we investigated time-course alterations of myocardial ET-1 gene expression and ET-1 peptide level in the heart of rats during a formative process of exercise training-induced cardiac hypertrophy. We used the hearts of rats that had been exercise-trained for 4 weeks (4WT) or 8 weeks (8WT) and sedentary control rats for 4 weeks (4WC) or 8 weeks (8WC). Exercise-trained rats performed treadmill running for 5 days/week (60 mins/day). Left ventricular mass index and wall thickness and stroke volume index, measured using echocardiography, in the 8WT group were significantly greater than in the 8WC group, although there were no differences between the 4WC and 4WT groups in these parameters. These results indicated that the 8WT rats developed physiologic cardiac hypertrophy, whereas the 4WT rats did not yet have cardiac hypertrophy. Myocardial ET-1 gene expression and tissue ET-1 concentration in the heart were significantly higher in the 8WT group than in the 8WC group, whereas these values did not differ between the 4WC and 4WT groups. The present study suggests that an alternation of myocardial ET-1 production corresponds with the formation of exercise training-induced cardiac hypertrophy. Therefore, the exercise training-induced change in myocardial ET-1 production may participate in a mechanism of exercise training-induced cardiac adaptation (e.g., cardiac hypertrophy).

  • Effect of eicosapentaenoic acid on the different endothelin system components in endothelin-1-induced hypertrophied cardiomyocytes

    N Shimojo, S Jesmin, S Zaedi, M Soma, T Kobayashi, S Maeda, Yamaguchi, I, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 888 - 892  2006年06月  [査読有り]

     概要を見る

    The cardiovascular benefit of fish oil, including eicosapentaenoic acid (EPA), in humans and experimental animals has been reported. The role of endothelin-1 (ET-1) in cardiac hypertrophy is well known. Endothelin-1 stimulates prepro-ET-1 mRNA expression in cardiomyocytes, and the autocrine/paracrine system of ET-1 is important for cardiomyocyte hypertrophy. Although many studies link EPA to cardiac protection, the effect of EPA on cardiac hypertrophy has yet to be clarified. Recently, we demonstrated that ET-1-induced cardiomyocytic change could be prevented by pretreatment with EPA. The present study investigated the changes of different components of the ET system at the mRNA level in ET-1-administered cardiomyocytes, and examined the effect of EPA pretreatment. Ventricular cardiomyocytes were isolated from 2-day-old Sprague-Dawley rats, cultured in Dulbecco's modified Eagle's medium and Ham F12 supplemented with 0.1% fatty acid-free bovine serum albumin for 3 days. At Day 4 of culture, the cardiomyocytes were divided into 3 groups: control group, ET-1-treated (0.1 nM) group, and ET-1-treated group pretreated with EPA (10 mu M). Twenty-four hours after treatment, the gene expressions of different components of the endothelin system in three experimental groups were evaluated by real-time polymerase chain reaction. Prepro-ET-1 mRNA expression was 53% upregulated in ET-1-induced hypertrophied cardiomyocytes and suppressed in the EPA-pretreated group. Endothelin-converting enzyme-1 (ECE-1) was also increased in ET-1 -administered cardiomyocytes by 42% compared with the control group and was reversed in the EPA-pretreated group. The two receptors of ET system, ETA and ETB, tended to be increased in the ET-1-treated group, but no statistical significance was seen among study groups. Endothelin-1 increased prepro-ET-1 and ECE-1 mRNA expression in hypertrophied-neonatal cardiomyocytes, and this was reversed with EPA pretreatment. Thus, EPA may play a crucial role in the regression of ET-1-induced cardiomyocyte hypertrophy, partly through the suppression of ET-1 and ECE-1 expression.

  • Differential effects of selective endothelin type A receptor antagonist on the gene expression of vascular endothelial growth factor and its receptors in streptozotocin-induced diabetic heart

    S Jesmin, S Zaedi, N Yamaguchi, S Maeda, N Shimojo, K Masuzawa, Yamaguchi, I, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 902 - 906  2006年06月  [査読有り]

     概要を見る

    Cardiovascular complications are an important feature of diabetes mellitus (DM). Abnormal and decreased coronary collateral development has been implicated in the pathogenesis of cardiac complications in DM. More recently, decreased expression of vascular endothelial growth factor (VEGF) and its receptors has been found in diabetic heart. To our knowledge, no study has focused on the therapeutic improvement associated with VEGF in diabetic heart. DM was induced by intraperitoneal injection of streptozotocin (65 mg/kg) in Sprague-Dawley rats, while control rats received only citrate buffer. After 1 week, the streptozotocin-treated rats were randomly divided into two groups: one group received the selective endothelin (ET) type A receptor antagonist TA-0201 at a dose of 1 mg/kg/day for 2 weeks by osmotic mini-pump, and the vehicle group received saline only. The plasma glucose level was 504 +/- 75 mg/dl in the diabetic rats and was unchanged by treatment with ET antagonist. The body weight was decreased in the diabetic rats compared with the control rats, but the left ventricular (LV)-body weight ratio was increased in the diabetic group and was unaffected by treatment with ET antagonist. mRNA expression of VEGF and its receptors (Flt-1 and Flk-1) in the LV tissues was assessed using real-time polymerase chain reaction. VEGF expression was significantly decreased in diabetic heart and was greatly improved by treatment with ET antagonist. The expression of VEGF receptors was downregulated in early diabetic heart but was not recovered by treatment with ET antagonist. ET and its receptor A might have differential regulation on the gene expressions of VEGF and its receptors in early diabetic heart.

  • Reversal of elevated cardiac expression of TGF beta(1) and endothelin-1 in OLETF diabetic rats by long-acting calcium antagonist

    S Jesmin, S Zaedi, S Maeda, CN Mowa, Sakuma, I, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 907 - 912  2006年06月  [査読有り]

     概要を見る

    The effects of calcium channel blockers (CCBs) on complications associated with diabetes mellitus (DM) have been well studied in clinical and basic science investigations. Cardiovascular complications are a common feature of type 2 DM, and insulin resistance is an early clinical manifestation of type 2 DM. CCBs are widely used to treat cardiovascular diseases in patients with DM. In this study, we used a spontaneous type 2 diabetic rat model, Otsuka Long-Evans Tokushima Fatty (OLETF) rats, at a highly insulin-resistant stage with modest hyperglycemia. We examined cardiac expression of transforming growth factor-beta(1) (TGF beta(1)) and endothelin-1 (ET-1) in male OLETF rats. At 8 weeks of age, OLETF rats were treated for 12 weeks with the long-acting CCB benidipine (1 mg/kg/day or 3 mg/kg/day, po, n = 12), with hydralazine hydrochloride (3 mg/kg/day, po, n = 12), or with vehicle (OLETF, n = 12), and male age-matched genetic control Long-Evans Tokushima Otsuka (LETO, n = 12) rats were used. Blood pressure was significantly higher in OLETF rats than in LETO rats, and benidipine treatment at both dosages in OLETF rats for 12 weeks did not significantly reduce blood pressure, whereas hydralazine treatment significantly lowered blood pressure in OLETF rats. Hydralazine and both dosages of benidipine significantly reduced upregulated cardiac ET-1 levels in OLETF rats. Plasma and cardiac TGFP, levels were remarkably higher in OLETF rats compared with LETO rats and were normalized by treatment with benidipine (3 mg/kg/day). Our results suggest that CCBs are effective in normalizing upregulated cardiac TGFP, and ET-1 levels at the insulin-resistant stage in OLETF rats, which may improve cardiac morphology and function in this rat model without altering blood pressure and plasma glucose levels. In contrast, hydralazine treatment also normalizes cardiac ET-1 levels while significantly reducing blood pressure.

  • EPA effect on NOS gene expression and on NO level in endothelin-1-induced hypertrophied cardiomyocytes

    N Shimojo, S Jesmin, S Zaedi, M Soma, T Kobayashi, S Maeda, Yamaguchi, I, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 913 - 918  2006年06月  [査読有り]

     概要を見る

    Cardiomyocytes release (or metabolize) several diffusible agents (e.g., nitric oxide [NO], endothelin-1 [ET-1], and angiotensin 11) that exert direct effects on myocyte function under various pathologic conditions. Although cardiac hypertrophy is a compensatory mechanism in response to different cardiovascular diseases, there can be a pathologic transition in which the myocardium becomes dysfunctional. Recently, NO has been found to be an important regulator of cardiac remodeling. Specifically, NO has been recognized as a potent antihypertrophic and proapoptotic mediator in cultured cardiomyocytes. We demonstrated that ET-1-induced hypertrophic remodeling in neonatal cardiomyocytes was arrested by pretreatment with eicosapentaenoic acid (EPA), a major component of fish oil. In some recent studies, EPA has demonstrated cardioprotective effects by modulating NO. This study investigated the changes in NO synthase (NOS) in ET-1-induced hypertrophied cardiomyocytes and in total levels of nitrates and nitrites. Ventricular cardiomyocytes were isolated from 2-day-old Sprague-Dawley rats and were cultured in D-MEM/Ham F12 supplemented with 0.1% fatty acid-free bovine serum albumin for 3 days. At Day 4 of culture, the cardiomyocytes were divided into three groups: control group, ET-1 (0.1 nM) group, and ET-1 pretreated with EPA (10 mu M) group. NOS gene expression was evaluated 24 hrs after treatment using real-time polymerase chain reaction. Endothelial NOS (eNOS) mRNA expression was decreased in the ET-1 group compared with controls and was unchanged by pretreatment with EPA. mRNA expression of inducible NOS (iNOS) was significantly increased in ET-1-treated cardiomyocytes and was suppressed by EPA pretreatment. Neuronal NOS gene expression and total NO level did not exhibit a statistically significant change in any of the groups. There may be some interaction between ET-1, eNOS, and iNOS in ET-1-induced and EPA-regressed hypertrophied cardiomyocytes that suppress iNOS expression without modulating total NO level or eNOS gene expression.

  • Endothelin antagonism suppresses plasma and cardiac endothelin-1 levels in SHRSPs at the typical hypertensive stage

    S Jesmin, S Zaedi, S Maeda, H Togashi, Yamaguchi, I, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 919 - 924  2006年06月  [査読有り]

     概要を見る

    Endothelin-1 (ET-1) has been implicated in hypertension, heart failure, atherosclerosis, and pulmonary hypertension. In all these conditions, plasma immunoreactive ET-1 levels are elevated, and tissue ET-1 expression is increased. Clinical trials have demonstrated potentially important benefits of ET antagonism among patients with essential hypertension, pulmonary hypertension, and heart failure. It is unknown whether ET antagonism affects the production of ET-1 in stroke-prone spontaneously hypertensive rat (SHRSP) heart at the typical hypertensive stage. The objective of this study was to investigate the effects of ET blockade on the expression levels of plasma and cardiac ET-1 in SHRSPs. SHRSPs were treated for 3 months with SB209670 (ETA/ETB dual receptor antagonist) or with saline (vehicle) commencing at the prehypertensive stage (age 6 weeks). Plasma and left ventricular ET-1 peptide levels were measured using enzyme-linked immunoabsorbent assay. Compared with age-matched control Wistar-Kyoto rats, peptide levels of ET-1 were significantly upregulated in vehicle-treated SHRSP heart; this upregulation was reversed by long-term ET antagonism. Plasma ET-1 levels were also significantly increased in vehicle-treated SHRSPs and were normalized by ET antagonism. mRNA expression of preproET-1, which is the source of ET-1 peptide production, was significantly increased in vehicle-treated SHRSP heart and was normalized by ET antagonism. Marked cardiac hypertrophy and fibrosis at the histologic level in SHRSPs were ameliorated by ET antagonism, and left ventricular hypertrophy as seen on echocardiography in SHRSPs was suppressed by ET blockade. After ET antagonism, systolic blood pressures were reduced in SHRSPs; diastolic blood pressures were unchanged. The reversal effect of the upregulated ET system in SHRSP heart by ET antagonism might be independent of blood pressure change. By suppressing the upregulated ET system, ET antagonism might be beneficial in arresting cardiac remodeling.

  • Changes in important apoptosis-related molecules in the endothelin-1-induced hypertrophied cardiomyocytes: Effect of the pretreatment with eicosapentaenoic acid

    N Shimojo, S Jesmin, S Zaedi, M Soma, S Maeda, Yamaguchi, I, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 932 - 936  2006年06月  [査読有り]

     概要を見る

    Human heart failure is preceded by a process called cardiac remodeling, in which heart chambers progressively enlarge and contractile function deteriorates. Programmed cell death (apoptosis) of cardiac muscle cells has been identified as an essential process in the progression to heart failure. The execution of the apoptotic program entails complex interactions between and execution of multiple molecular subprograms. Endothelin (ET)-1, a potent vasoconstrictor peptide, is synthesized and secreted by cardiomyocytes and induces hypertrophy of cardiomyocytes. The cardiovascular benefit of fish oil containing eicosapentaenoic acid (EPA) in humans and experimental animals was reported. Recently, we found that ET-1-induced cardiomyocytic remodeling could be prevented by pretreatment with EPA. The aim of the present study is to investigate whether there would be any alteration in the expression of important apoptosis-related molecules in ET-1-administered hypertrophied cardiomyocytes. We also sought to determine, if there are alterations in apoptotic molecules, what type of role for EPA would then exist. Ventricular cardiomyocytes were isolated from 2-day-old Sprague-Dawley rats and were cultured for 3 days. At Day 4 of culture, the cardiomyocytes were divided into three groups: control, the ET-1 (0.1 nM)- treated group, and the ET-1 group pretreated with EPA (10 mu M). Twenty-four hours after the treatment, the gene expressions of three important molecules related to apoptosis (caspase-3, Bax, and Bcl-2) in three experimental groups were evaluated by real-time polymerase chain reaction. The present study could not demonstrate any significant or representative alteration in any of the above three apoptosis-related important markers in either ET-1-induced hypertrophied cardiomyocytes with or without EPA pretreatment. The present study would at least be able to exclude the involvement of some representative molecules related to apoptosis in ET-1-induced hypertrophied cardiomyocytes. In addition, the present study demonstrates that the antihypertrophic effect of EPA to ET-1-administered cardiomyocytes appears not to modulate the apoptosis signaling cascade.

  • Alterations in gene expressions encoding preproET-1 and NOS in pulmonary tissue in endotoxemic rats

    S Zaedi, S Jesmin, S Maeda, N Shimojo, Yamaguchi, I, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 992 - 996  2006年06月  [査読有り]

     概要を見る

    Septic shock is characterized by hypotension and a hyporeactive response to vasopressor agents. The pathogenesis is due to vascular leaks and an increased synthesis of cytokines and nitric oxide (NO). The present study examined the time-dependent alterations of endothelin-1 (ET-1) and the expression of NO synthase (NOS) in lung tissue in a septic rat model. Normal Sprague-Dawley (SD) rats aged 10 weeks received 15 mg/kg lipopolysaccharide (LPS) and then were sacrificed at different time points (1, 3, 6, and 10 hrs). Rats that did not receive LPS were considered to be controls. Both systolic and diastolic pressure decreased in SD rats after LPS administration. Time-dependent onset of features of acute lung injury, such as the infiltration of inflammatory cells and thickening of alveolar septa, were seen in rats that received LPS. A 2.8-fold increase in the expression of preproET-1 level was observed in lung tissue 6 hrs after LPS administration. The expression of endothelial NOS (eNOS) was also altered in lung tissue in a time-dependent fashion. After the administration of LPS, there was a 16-fold increase in the expression of eNOS mRNA. The peak expression of inducible NOS (iNOS) in lung tissue specimens obtained from rats that received LPS was 45-fold higher than that in control rats. ET-1 is a potent vasoconstrictor and thereby may play an important role in the pathogenesis of acute lung injury in a septic rat model. The increased expression of NOS may result in excess NO production and may also play a role in the pulmonary complications of endotoxemia.

  • Effects of dual endothelin receptor antagonist on antiapoptotic marker Bcl-2 expression in streptozotocin-induced diabetic rats

    S Jesmin, S Zaedi, N Yamaguchi, S Maeda, Yamaguchi, I, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 1034 - 1039  2006年06月  [査読有り]

     概要を見る

    Erectile dysfunction (ED) affects approximately 50% of male patients with diabetes mellitus (DM) and is possibly due to the vascular and neuropathic complications of DM. Recently, apoptosis has been regarded as a downstream event in ED. More recently, the importance of alterations in apoptosis-related molecules in the mechanism of DM-induced ED has begun to be appreciated. Endothelin-1 (ET-1) plays a role via ETA and ETB receptors in the regulation of cavernosal smooth-muscle tone in penile tissues. We found that the ET-1 level in the penis of rats with DM was higher than that in the penis of control animals. The present study investigated a rat model in which DM was induced by a 3-week regimen of streptozotocin (STZ) to assess the expression of several apoptosis-related molecules in penile tissue and, concomitantly, the effects of ET antagonism on these changes. Male Sprague-Dawley rats (weight [+/- SD], 450 +/- 26 g) received a citrate saline vehicle or STZ (65 mg/kg ip). DM was confirmed by the presence of hyperglycemia. Diabetic animals were further separated into two treatment groups 1 week after onset of disease: one group received ETA/B dual receptor antagonist (SB209670) by means of osmotic minipump at a dosage of 1 mg/day, and the other group received saline. Rats in both groups were treated for 2 weeks and then sacrificed. Plasma glucose levels (+/- SD) in rats with DM were significantly higher than those in rats without DM (506 +/- 70 vs. 111 +/- 11 mg/dl). In the penile tissue of rats with DM, a 35% decrease in the expression of Bcl-2 protein (an important antiapoptotic marker detectable by immunoblotting) was seen, and ETA/B dual antagonist was observed to significantly counteract this decrease. Real-time polymerase chain reaction revealed that the expression of Bcl-2 mRNA was consistent with Bcl-2 protein expression. Levels of Bax and caspase-3, two important proapoptotic markers, were not significantly altered in the present study. Thus, we conclude that, in the penis of rats with early stage DM, the protection against apoptosis has decreased but can be improved by ET antagonism.

  • Weight loss reduces plasma endothelin-1 concentration in obese men

    S Maeda, S Jesmin, M Emitsu, T Otsuki, T Matsuo, K Ohkawara, Y Nakata, K Tanaka, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 1044 - 1047  2006年06月  [査読有り]

     概要を見る

    Obesity is associated with endothelial dysfunction that may contribute to the development of diabetes, hypertension, and atherosclerosis. Endothelin-1 (ET-1), which is produced mostly by vascular endothelial cells, has potent vasoconstrictor and proliferative activity in vascular smooth muscle cells and, therefore, has been implicated in regulation of vascular tonus and the progression of atherosclerosis, suggesting that ET-1 may be important in endothelial dysfunction. We studied whether diet-induced weight loss (i.e., lifestyle modification) affects plasma ET-1 concentration in obese individuals. We measured plasma ET-1 concentration in seven obese men (age: 48 +/- 4 years old, body mass index: 27.7 +/- 0.5 kg/m(2)) before and after a 3-month, diet-induced weight reduction program (i.e., lifestyle modification program). Caloric restriction reduced body weight from 78 +/- 3 to 68 +/- 2 kg (P &lt; 0.001) and resulted in 12.1 +/- 1.2% reduction in body mass index (24.3 +/- 0.3 kg/m(2), P &lt; 0.0001). After the weight reduction program, systolic and diastolic blood pressure significantly decreased (128 +/- 7 vs. 115 +/- 4 mm Hg, P &lt; 0.05 and 88 +/- 4 vs. 77 +/- 2 min Hg, P &lt; 0.01, respectively). The plasma level of ET-1 significantly decreased after the program (5.1 +/- 0.4 vs. 4.0 +/- 0.3 pg/ml, P &lt; 0.05). The percentage systolic blood pressure reduction and percentage plasma ET-1 concentration reduction was in a linear relationship (r = 0.86, P &lt; 0.05). Furthermore, the relationship between percentage weight reduction and percentage plasma ET-1 concentration reduction was linear (r = 0.87, P &lt; 0.05). We conclude that weight loss by low-calorie diet (i.e., lifestyle modification) reduces plasma ET-1 concentration in obese individuals. This reduction may contribute to the improvement of obesity-induced endothelial dysfunction.

  • A model of retinal ischemia-reperfusion injury in rats by subconjunctival injection of endothelin-1

    K Masuzawa, S Jesmin, S Maeda, Y Kaji, T Oshika, S Zaedi, N Shimojo, N Yaji, T Miyauchi, K Goto

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 1085 - 1089  2006年06月  [査読有り]

     概要を見る

    The retinal ischemia-reperfusion model is used in the study of transient ischemia-related diseases, such as central retinal artery occlusion, angle-closure glaucoma, and others. There are two methods for experimentally producing an ischemia-reperfusion model in the rat retina: (i) the intraocular pressure is greatly raised by increasing the height of the infusion bottle connected with the needle in the anterior chamber; or (ii) the blood vessel that accompanies the optic nerve in retina is ligated. However, each method has some drawbacks. For example, in the first method, the needle must be fixed in the anterior chamber for 1 hr, thus, the technique is not stable and mechanical damage to ocular structures sometimes occurs. In the second method, because of the unavoidable involvement of the optic nerve, damage to the nerve induces retinal changes unrelated to ischemia. In this study, we injected endothelin (ET)-1 under the conjunctiva of the eyeball (subconjunctival injection), and evaluated whether a retinal ischemia-reperfusion model could be generated by this method, simply and noninvasively. We injected 4 X 10(-5) M ET-1 solution into the right eye of the rat and injected a control vehicle (artificial tears) into the left eye. From 5-60 mins after the injection, 50 mg/ml fluorescein isothiocyanate (FITC)-dextran was injected to the left ventricle of heart. Then, the retina was removed and flat mounted. We compared the perfusion conditions of the FITC-dextran to each retina in the right and left eye. There was a complete perfusion of FITC-dextran in the retinal main artery, vein, and the capillary vessels in all of the control eyes. However, perfusion could not be completely observed in the ET-1 injected eye from 5-35 mins after injection; afterwards, the flow was returned. This method of subconjunctival injection of ET-1 is, thus, a feasible technical option for producing a retinal ischemia-reperfusion model in rat.

  • Effect of endothelin dual receptor antagonist on VEGF levels in streptozotocin-induced diabetic rat retina

    K Masuzawa, S Jesmin, S Maeda, S Zaedi, N Shimojo, T Miyauchi, K Goto

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 1090 - 1094  2006年06月  [査読有り]

     概要を見る

    Diabetic retinopathy (DR), one of the most serious causes of blindness, is often associated with the upregulation of vascular endothelial growth factor (VEGF) in retina. Recently, leukocyte adhesion (leukostasis) is blamed for the occlusion of retinal capillary vascularity, which ultimately contributes to the progression of diabetic retinopathy. In addition, intercellular adhesion molecule-1 (ICAM-1), a representative factor for leukostasis, is increased in the diabetic retina. Endothelin (ET)-1, a potent vasoconstrictor peptide, is deeply linked to the pathogenesis of diabetic retinopathy. Different therapeutic interventions concerning VEGF have already been proposed to prevent diabetic retinopathy. However, no study yet has reported whether ET-1 dual receptor antagonist could alter the upregulated VEGF and ICAM-1 levels in the diabetic retina. The present study investigated the effect of ETA/B dual receptor antagonist (SB209670; 1 mg/rat/day) on the expression of VEGF and ICAM-1 in the diabetic rat retina. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ; 65 mg/kg) in Sprague-Dawley rats, whereas control rats (non-DM control) received only citrate buffer. After 1 week, the STZ-administered rats were randomly divided into two groups: one group (DM+SB209670) received ETA/B dual receptor antagonist for 2 weeks, and a vehicle group (DM+vehicle) was treated only with saline. After the treatment period, the retinas were removed from the eyeballs. In DM+vehicle group, the VEGF expression of the retinas was significantly increased (32.8 pg/mg) in comparison to that in the non-DM control group (26.2 pg/mg); this upregulation of VEGF was reversed in the DM+SB209670 group (28.6 pg/mg). The expression of retinal ICAM-1 was increased in the DM+vehicle group (152.2 pg/mg) compared with the non-DM control group (121.6 pg/mg). However, SB209670 treatment did not alter the expression of retinal ICAM-1 level (154.8 pg/ml) in DM rats. Thus we conclude that an ETA/B dual receptor antagonist could reverse the expression level of VEGF in the diabetic retina while failing to normalize the upregulated ICAM-1 expression.

  • Altered expression of endothelin, vascular endothelial growth factor, and its receptor in hepatic tissue in endotoxemic rat

    S Zaedi, S Jesmin, N Yamaguchi, N Shimojo, S Maeda, S Gando, Yamaguchi, I, K Goto, T Miyauchi

    EXPERIMENTAL BIOLOGY AND MEDICINE   231 ( 6 ) 1182 - 1186  2006年06月  [査読有り]

     概要を見る

    Sepsis involves a heterogeneous class of syndromes, and septic shock, a severe form of sepsis, is associated with the development of progressive damage in multiple organs. The present study examined the time-dependent alterations of endothelin-1 (ET-1) and vascular endothelial growth factor (VEGF) levels in liver tissue in a septic rat model. Healthy male Wistar rats aged 15 weeks received 15 mg/kg lipopolysaccharide (LPS) and were sacrificed at different time points (1, 3, 6, and 10 hrs after treatment). Rats that did not receive LPS were considered to be controls. A 28-fold increase in the ET-1 level was observed in liver tissue 10 hrs after LPS administration. VEGF was also altered in hepatic tissue in a time-dependent manner. A gradual increase of VEGF expression in liver tissue after LPS administration was observed. Expression of Flt-1, the vascular permeability receptor of VEGF, was also increased in liver tissue after LPS administration. ET-1 is a potent vasoconstrictor and, therefore, may play a role in the regulation of hepatic perfusion in a sepsis model. On the other hand, VEGF may be involved in capillary leakage in liver tissue after LPS administration. The present findings suggest that there might be a loss of balance between the ET-1 and VEGF levels in the septic liver at different time points, which could contribute to the pathogenesis of acute liver injury in endotoxemia.

  • Contribution of Arterial Compliance and Vascular Resistance to Effective Arterial Elastance Changes During Exercise

    Otsuki Takeshi, Maeda Seiji, Iemitsu Motoyuki, Saito Yoko, Tanimura Yuko, Ajisaka Ryuichi, Miyauchi Takashi

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   38 ( 5 ) S185  2006年05月  [査読有り]

    DOI

  • Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects

    M Iemitsu, S Maeda, T Otsuki, J Sugawara, T Tanabe, S Jesmin, S Kuno, R Ajisaka, T Miyauchi, M Matsuda

    HYPERTENSION   47 ( 5 ) 928 - 936  2006年05月  [査読有り]

     概要を見る

    Increase in arterial stiffness is associated with aging, which is improved by regular exercise. Endothelin ( ET) system has crucial roles in regulating vascular tone and in the progression of atherosclerosis. We hypothesized that molecular variations ( ie, gene polymorphisms) in ET- related gene might affect exercise- induced improvement in arterial stiffness with age in human subjects. The present study provides a cross- sectional investigation of 191 healthy middle- aged and older ( 65 +/- 1 years) human subjects to clarify the relationship between the regular exercise- induced improvement of arterial stiffness and the gene polymorphisms of ET converting enzyme ( ECE)- 1, ECE- 2, ET- A receptor ( ET- A), and ET- B receptor ( ET- B). The study subjects were divided into active and inactive groups based on the median value ( 186 kcal/ d) of energy expenditure. Brachial- ankle arterial pulse wave velocity ( baPWV) was used to evaluate arterial stiffness. All individuals were genotyped for 4 different polymorphisms of the ET system: 2013( + 289) A/ G in intron 17 of ECE- 1, 669( + 17) T/ C in intron 5 of ECE- 2, 958A/ G in exon 6 of ET- A, and 831A/ G in exon 4 of ET- B. The baseline baPWV was significantly lower in the active group without any change in blood pressure. Polymorphisms in ECE- 1 influenced basal blood pressure. Polymorphisms in ECE- 1 and ECE- 2 had no effect on baPWV between active and inactive groups. However, polymorphisms in both ET- A and ET- B affected baPWV in the 2 groups. The present results suggest that differences in ET- A and ET- B polymorphisms may influence the response of the vascular wall to exercise whereas ECE- 1 polymorphisms may affect basal blood pressure.

    DOI

  • 持久力及び筋力強化のトレーニングをした青年期の運動選手における動脈硬化度と競技スポーツキャリア(Arterial Stiffness and Competitive Sports Career in Adolescent Endurance- and Strength-trained Athletes)

    Otsuki Takeshi, Maeda Seiji, Iemitsu Motoyuki, Saito Yoko, Tanimura Yuko, Ajisaka Ryuichi, Miyauchi Takashi, Yamaguchi Iwao

    Circulation Journal   70 ( Suppl.I ) 478 - 478  2006年03月

  • 若年者における大動脈硬化度及び血漿中エンドセリン1濃度に及ぼす筋力運動及び持久運動トレーニングの効果(Effects of Athletic Strength- and Endurance-exercise Training on Aortic Stiffness and Plasma Endothelin-1 Concentration in Young Humans)

    Otsuki Takeshi, Miyauchi Takashi, Maeda Seiji, Iemitsu Motoyuki, Saito Yoko, Tanimura Yuko, Ajisaka Ryuichi, Goto Katsutoshi, Yamaguchi Iwao

    Circulation Journal   70 ( Suppl.I ) 499 - 499  2006年03月

  • PJ-393 Changes of Myocardial Endothelin-1 Level during the Formation of Exercise Training-induced Cardiac Adaptation(Exercise test/Cardiac rehabilitation-3 (IHD) PJ66,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese

    Iemitsu, Motoyuki, Miyauchi, Takashi, Maeda, Seiji, Goto, Katsutoshi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 587  2006年03月

  • PJ-042 Effects of Athletic Strength- and Endurance-exercise Training on Aortic Stiffness and Plasma Endothelin-1 Concentration in Young Humans(Exercise test/Cardiac rehabilitation-5 (IHD) PJ7,Poster Session (Japanese),The 70th Anniversary Annual Scientifi

    Otsuki, Takeshi, Miyauchi, Takashi, Maeda, Seiji, Iemitsu, Motoyuki, Saito, Yoko, Tanimura, Yuko, Ajisaka, Ryuichi, Goto, Katsutoshi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 499  2006年03月

  • PE-611 Estrogen Receptor Alpha is More Actively Involved in the Cardiac VEGF/KDR/NO Pathway Compared to Estrogen Receptor Beta in Female Mice(Neurohumoral factors-2 (H) PE108,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the J

    Jesmin, Subrina, Miyauchi, Takashi, Zaedi, Sohel, Iemitsu, Motoyuki, Maeda, Seiji, Sakuma, Ichiro, Hattori, Yuichi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 483 - 484  2006年03月

  • PE-581 Arterial Stiffness and Competitive Sports Career in Adolescent Endurance- and Strength-trained Athletes(Exercise test/Cardiac rehabilitation-2 (IHD) PE101,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circu

    Otsuki, Takeshi, Maeda, Seiji, Iemitsu, Motoyuki, Saito, Yoko, Tanimura, Yuko, Ajisaka, Ryuichi, Miyauchi, Takashi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 478  2006年03月

  • PE-243 Endothelin Receptor Antagonist Ameliorates the Cardiac Dysfunction, Decreased Cardiac VEGF Signaling and Inadequate Coronary Collateral Development in Early Diabetic Rats(Diabetes/Obesity/Metabolic syndrome-8 (H) PE41,Poster Session (English),The 7

    Jesmin, Subrina, Miyauchi, Takashi, Iemitsu, Motoyuki, Zaedi, Sohel, Yamaguchi, Naoto, Shimojo, Nobutake, Maeda, Seiji, Goto, Katsutoshi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 394  2006年03月

  • PE-188 Dual Endothelin Receptor Antagonist Reverses the Upregulated VEGF-KDR Axis in Frontal Cortex of SHR-SP without Modulating the Cerebral Blood Flow(Cerebrovascular circulation/Stroke-2 (IHD) PE32,Poster Session (English),The 70th Anniversary Annual S

    Jesmin, Subrina, Miyauchi, Takashi, Zaedi, Sohel, Iemitsu, Motoyuki, Togashi, Hiroko, Maeda, Seiji, Goto, Katsutoshi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 381 - 382  2006年03月

  • OJ-146 Exercise Training Improves Aging-induced Decrease of Energy Metabolic Molecular System through Peroxisome Proliferator-activated Receptor γ Coactivator-1 α (PGC-1 α) in the Heart(Exercise test/Cardiac rehabilitation-1 (IHD) OJ25,Oral Presentation (

    Iemitsu, Motoyuki, Maeda, Seiji, Miyauchi, Takashi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 270 - 271  2006年03月

  • OJ-145 Exercise Training Improves Aging-induced Impairment of Angiogenesis through Upregulation of VEGF and Flk-1 in the Heart(Exercise test/Cardiac rehabilitation-1 (IHD) OJ25,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of

    Iemitsu, Motoyuki, Maeda, Seiji, Jesmin, Subrina, Miyauchi, Takashi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 270  2006年03月

  • OE-298 Eicosapentaenoic Acid, a Major Component of Fish Oil, Prevents the Progression of Endothelin-1-Induced Cardiomyocyte Hypertrophy through Suppressing Phosphorylated JNK(Cardiovascular pharmacology, basic/clinical-1 (H) OE50,Oral Presentation (Englis

    Shimojo, Nobutake, Miyauchi, Takashi, Jesmin, Subrina, Zaedi, Sohel, Soma, Masaaki, Maeda, Seiji, Goto, Katsutoshi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 223  2006年03月

  • OE-176 Endothelin-1 Induces the Expressions of VEGF and Its Receptors (Flt-1 and Flk-1) in Neonatal Cardiomyocytes in Vitro Dosedependently(Neurohumoral factors-1 (H) OE30,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the J

    Shimojo, Nobutake, Miyauchi, Takashi, Jesmin, Subrina, Zaedi, Sohel, Maeda, Seiji, Goto, Katsutoshi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   70 ( 0 ) 192 - 193  2006年03月

  • Age-related reduction of systemic arterial compliance induces excessive myocardial oxygen consumption during sub-maximal exercise

    T Otsuki, S Maeda, Y Kesen, N Yokoyama, T Tanabe, J Sugawara, T Miyauchi, S Kuno, R Ajisaka, M Matsuda

    HYPERTENSION RESEARCH   29 ( 2 ) 65 - 73  2006年02月  [査読有り]

     概要を見る

    Reduction of systemic arterial compliance (SAC) with aging increases left ventricular afterload. The present study was designed to examine whether age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise. We studied elderly (60-69 years; n = 25) and senior (70-82 years; n = 25) subjects. We measured SAC immediately before the start of the ramp-fashion exercise (Le., at the end of the 20 W warm-up exercise) and the double product (DP: systolic blood pressure x heart rate) during the ramp-fashion exercise (20-50 W). SAC was significantly lower in senior subjects (0.76 +/- 0.25 ml mmHg(-1) m(-2)) compared with elderly subjects (0.95 +/- 0.22 ml mmHg(-1) m(-2)). DP was higher in senior subjects (20 W: 14.3 +/- 3.1; 30 W: 15.9 +/- 4.2; 40 W: 17.7 +/- 4.9; 50 W: 20.6 +/- 5.6 [x 10(3) mmHg bpm]) than in elderly subjects (12.8 +/- 3.0, 14.0 +/- 3.5, 15.1 +/- 4.0, 17.1 +/- 4.3 [x 10(3) mmHg bpm]). In total subjects, SAC correlated significantly with DID (r = -0.64, r = -0.64, r = -0.64, r = -0.64). In senior subjects, SAC was related significantly to DP (r = -0.83, r = -0.78, r = -0.76, r = -0.74). In elderly subjects, SAC tended to correlate with DP although its relationships were not statistically significant (r = -0.34, r = -0.36, r = -0.33, r = -0.31). Correlation coefficients at each respective exercise intensity were significantly higher in senior subjects compared with elderly subjects. These results suggest that the age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise in older humans, but this relation does not become significant until the SAC reduction becomes pronounced.

  • 運動による心臓の遺伝子発現と転写調節(ワークショップ8:健康と遺伝子,第61回日本体力医学会大会)

    家光, 素行, 前田, 清司, 宮内, 卓

    体力科學   55 ( 1 ) 85 - 86  2006年02月

  • Age-related reduction of systemic arterial compliance induces excessive myocardial oxygen consumption during sub-maximal exercise

    T Otsuki, S Maeda, Y Kesen, N Yokoyama, T Tanabe, J Sugawara, T Miyauchi, S Kuno, R Ajisaka, M Matsuda

    HYPERTENSION RESEARCH   29 ( 2 ) 65 - 73  2006年02月

     概要を見る

    Reduction of systemic arterial compliance (SAC) with aging increases left ventricular afterload. The present study was designed to examine whether age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise. We studied elderly (60-69 years; n = 25) and senior (70-82 years; n = 25) subjects. We measured SAC immediately before the start of the ramp-fashion exercise (Le., at the end of the 20 W warm-up exercise) and the double product (DP: systolic blood pressure x heart rate) during the ramp-fashion exercise (20-50 W). SAC was significantly lower in senior subjects (0.76 +/- 0.25 ml mmHg(-1) m(-2)) compared with elderly subjects (0.95 +/- 0.22 ml mmHg(-1) m(-2)). DP was higher in senior subjects (20 W: 14.3 +/- 3.1; 30 W: 15.9 +/- 4.2; 40 W: 17.7 +/- 4.9; 50 W: 20.6 +/- 5.6 [x 10(3) mmHg bpm]) than in elderly subjects (12.8 +/- 3.0, 14.0 +/- 3.5, 15.1 +/- 4.0, 17.1 +/- 4.3 [x 10(3) mmHg bpm]). In total subjects, SAC correlated significantly with DID (r = -0.64, r = -0.64, r = -0.64, r = -0.64). In senior subjects, SAC was related significantly to DP (r = -0.83, r = -0.78, r = -0.76, r = -0.74). In elderly subjects, SAC tended to correlate with DP although its relationships were not statistically significant (r = -0.34, r = -0.36, r = -0.33, r = -0.31). Correlation coefficients at each respective exercise intensity were significantly higher in senior subjects compared with elderly subjects. These results suggest that the age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise in older humans, but this relation does not become significant until the SAC reduction becomes pronounced.

  • 身体運動と心血管系機能

    前田 清司

    学術の動向   11 ( 10 ) 36 - 41  2006年

    DOI CiNii

  • Activation of multiple mitogen-activated protein kinase (MAPK) signaling pathways in rat heart by exercise.

    Iemitsu M, Maeda S, Jesmin S, Otsuki T, Kasuya Y, Miyauchi T

    Journal of Applied Physiology   101   151-163  2006年

  • 習慣的な有酸素運動が動脈コンプライアンスに及ぼす影響はありますか? また,運動様式の違いにより動脈コンプライアンスは異なりますか?.

    家光素行, 前田清司, 宮地元彦, 田中弘文

    Arterial Stiffness   10   112  2006年

  • Endothelin-1 induces the expressions of VEGF and its receptors (Flt-1 and Flk-1) in neonatal cardiomyocytes in vitro dose-dependently. Proceeding of the 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society

    Shimojo, N, Miyauchi, T, Jesmin, S, Zaedi, S, Maeda, S, Goto, K, Yamaguchi, I

    Circulation Journal   70 ( 1 ) 192 - 192  2006年  [査読有り]

  • Endothelin receptor antagonist ameliorates the cardiac dysfunction, decreased cardiac VEGF signaling and inadequate coronary collateral development in early diabetic rats.Proceeding(Original article peer reviewed)

    Jesmin, S, Miyauchi, T, Iemitsu, M, Zaedi, S, Shimojo, N, Yamaguchi, N, Maeda, S, Goto, K, Yamaguchi, I

    Circulation Journal   70   394  2006年  [査読有り]

  • Exercise training improves aging-induced impairment of angiogenesis through upregulation of VEGF and Flk-1 in the heart.Proceeding of the 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society

    Iemitsu, M, Maeda, S, Jesmin, S, Miyauchi, T, Yamaguchi, I

    Circulation Journal   70 ( 1 ) 270 - 270  2006年  [査読有り]

  • Eicosapentaenoic acid, a major component of fish oil, prevents the progression of endothelin-1-induced cardiomyocyte hypertrophy through suppressing phosphorylated JNK.Proceeding of the 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio

    Shimojo, N, Miyauchi, T, Jesmin, S, Zaedi, S, Soma, M, Maeda, S, Goto, K, Yamaguchi, I

    Circulation Journal   70 ( 1 ) 223 - 223  2006年  [査読有り]

  • Dual Endothelin Receptor Antagonist Reverses the Upregulated VEGF-KDR axis and Decreased eNOS Level in the Frontal Cortex of SHR-SP without Modulating the Cerebral Blood Flow.Proceeding of the 70th Anniversary Annual Scientific Meeting of the Japanese Cir

    Jesmin, S, Miyauchi, T, Shimojo, N, Zaedi, S, Iemitsu, M, Togashi, H, Maeda, S, Goto, K, Yamaguchi, I

    Circulation Journal   70   381 - 382  2006年  [査読有り]

  • Estrogen Receptor Alpha Is More Actively Involved in the Cardiac VEGF/KDR/NO Pathway Compared to Estrogen Receptor Beta in Female Mice.Proceeding of the 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society

    Jesmin, S, Miyauchi, T, Zaedi, S, Iemitsu, M, Maeda, S, Sakuma, I, Hattori, Y, Yamaguchi, I

    9 Official Journal of Japanese Circulation Society, Circulation Journal   70   483 - 484  2006年  [査読有り]

  • Endothelin Antagonism Normalizes Impairments in VEGF Signaling, Coronary Collateral Development and Cardiac Function in Early Diabetic Rat Heart.Proceeding ofAmerican Heart Association's Scientific Sessions 2006

    Jesmin, S, Maeda, S, Shimojo, N, Zaedi, S, Iemitsu, M, Hattori, Y, Miyauchi, T

    Circulation Journal   114 ( 2 ) 21  2006年  [査読有り]

  • An endothelin type A receptor antagonist reverses upregulated VEGF and ICAM-1 levels in streptozotocin-induced diabetic rat retina

    K Masuzawa, K Goto, S Jesmin, S Maeda, T Miyauchi, Y Kaji, T Oshika, S Hori

    CURRENT EYE RESEARCH   31 ( 1 ) 79 - 89  2006年01月  [査読有り]

     概要を見る

    Diabetic retinopathy, a cause of blindness, is often associated with the upregulation of vascular endothelial growth factor (VEGF) in the retina. Recently, leukocyte adhesion (leukostasis) is claimed for the occlusion of retina] capillary vascularity, which ultimately assists in the progression of diabetic retinopathy. In addition, intercellular adhesion molecule-1 (ICAM-1), a representative factor for leukostasis, is increased in diabetic retina. Endothelin (ET)-1, a potent vasoconstrictor peptide, is closely linked to the pathogenesis of diabetic retinopathy. Different therapeutic interventions concerning VEGF have already been proposed to prevent diabetic retinopathy. However, no study has yet reported concerning the effects of ET-I receptor antagonist on the upregulated VEGF and ICAM-1 in morphologically intact diabetic retina. The current study investigated the effect of ETA receptor antagonist (TA-0201; 1 mg kg(-1) day(-1)) on the expressions of VEGF and ICAM-I in rat diabetic retina. Diabetes was induced by intraperitoneal injection of streptozotocin (70 mg/kg) in Sprague-Dawley rats, whereas control rats (Cont) received only citrate buffer. After I week, the streptozotocin-administered rats were randomly divided into two groups: ETA receptor antagonist-treated group (DM+TA-0201) and saline-treated group (DM+vehicle). After the treatment for 4 weeks, the retina was removed from the eyeball. In DM+vehicle group, the VEGF expression of retina was significantly increased (33.5 pg/mg) in comparison with that in the Cont group (25.1 pg/mg), and the upregulation of VEGF was reversed in DM+TA-0201 group (26.9 pg/mg), a phenomenon consistent with the change in VEGF mRNA levels. The expression of retinal ICAM-I was increased in DM+vehicle group (55.1 pg/mg) compared with Cont group (43.8 pg/mg), and ET antagonism completely blocked this increase (43.8 pg/mg). Moreover, an increased leukostasis by 3.3-fold in DM+vehicle retina was returned to the control level by ET antagonism. In the current study, there was no obvious retinal morphological alteration from both the hematoxylin and eosin staining and the FITC-dextran angiography. Thus, ETA receptor antagonist might be useful in preventing the progression of diabetic retinopathy, as evidenced by suppressing the increase in VEGF and ICAM-1 levels as well as leukostasis in morphologically intact diabetic retina.

    DOI

  • Association between the Ventilatory Treshold and the Break-point in the Heart Rate/Work Rate Relationship: Comparison with the Break-point in the Double Product/Work Rate

    Sugawara, Jun, Otsuki, Takeshi, Tanabe, Takumi, Takahashi, Kouki, Yamazaki, Ken, Hayashi, Koichiro, Yoshino, Kozo, Matsuoka, Katsunori, Arai, Kazuhiko, Maeda, Seiji, Kuno, Shinya, Ajisaka, Ryuichi, Matsuda, Misuo

    International Journal of Sport and Health Science   4 ( 2 ) 499 - 507  2006年01月  [査読有り]

     概要を見る

    The aim of this study was to assess the usefulness of the break-point in the heart rate/work rate relationship (HRBP). Ninety-seven middle-aged and elderly people performed a ramp-fashion incremental exercise test on a cycle ergometer. Breath-by breath O2 consumption and CO2 production data and beat-to-beat systolic blood pressure and heart rate data were obtained during the test, and work rate and heart rate corresponding to ventilatory threshold (VT), double product break point (DPBP), and HRBP were obtained by a linear regression analysis. Work rate and heart rate at HRBP correlated significantly with the corresponding values at VT (r=0.773, r=0.858, both P<0.0001), as work rate and heart rate at DPBP did (r=0.873, r=0.905, both P<0.0001). Work rate at DPBP and HRBP (60±13 and 61±13 watts) did not significantly differ from work rate at VT (61±13 watts), whereas heart rates at DPBP and HRBP (105±14 and 106±13 bpm) were significantly lower than that at VT (108±14 bpm, P<0.05). However, there was no significant difference in error from heart rate at VT between heart rate at DPBP and heart rate at HRBP. These results suggest that, in middle-aged and elderly people, HRBP could

  • Effect of Daily Physical Activity on Systemic Arterial Compliance in Middle-aged and Elderly Humans: Special References in Amount and Intensity of Physical Activity

    Tanabe, Takumi, Maeda, Seiji, Sugawara, Jun, Otsuki, Takeshi, Kuno, Shinya, Ajisaka, Ryuichi, Matsuda, Mitsuo

    International Journal of Sport and Health Science   4 ( 2 ) 489 - 498  2006年01月  [査読有り]

     概要を見る

    In our previous study, we demonstrated that an increase in the amount of daily physical activity might produce beneficial effects on aging-induced reduction of systemic arterial compliance. Regular physical activity, especially vigorous activity levels, inhibits age-related decrease in sytemic or central arterial compliance. However, the effect of mild to moderate intensity of physical activity has not been fully elucidated. The purpose of the present study was to investigate which intensity level of physical activity would be effective to improve systemic arterial compliance. We examined the relationship between systemic arterial compliance and intensity levels of daily physical activity (activity time corresponding to <3 METs [low], <3 METs and <6 METs [mild-moderate], and >6 METs [high]) in 413 middle-aged and elderly subjects (46∼85 y). Multiple regression analysis detected age and time of mild-moderate intensity of daily physical activity as significant independent determinants of systemic arterial compliance. The time of mild-moderate intensity of daily physical activity was significantly related to age and amount of daily physical activity. After age and amount of daily ph

  • Gene Expression Profiling of Exercise-induced Cardiovascular Adaptations: Molecular Insight from Microarray Analyses

    Iemitsu, Motoyuki, Maeda, Seiji, Miyauchi, Takashi, Kuno, Shinya, Murakami, Kazuo, Matsuda, Mitsuo

    International Journal of Sport and Health Science   4 ( 2 ) 451 - 459  2006年01月  [査読有り]

     概要を見る

    Exercise training causes some physiological cardiovascular adaptations, which act to enhance cardiac and vascular functions at rest and during exercise. However, the molecular mechanisms of these adaptations are unclear. We investigated gene expression profiles of exercise training-induced cardiovascular adaptations. In the experiment, rats exercised on a treadmill for 4 or 8 weeks (4WT and 8WT). The differences in expression levels of 3,800 genes in the heart and abdominal aorta of sedentary control and exercise-trained rats were compared by the microarray analysis. Of the 3,800 genes analyzed in the microarray analyses, in the heart, a total of 45 genes (upregulation of 3 genes and downregulation of 42 genes) in the 4WT and 74 genes (upregulation of 50 genes and downregulation of 24 genes) in the 8WT displayed altered gene expression with exercise training. In the aorta, a total of 57 genes (upregulation of 35 genes and downregulation of 24 genes) in the 4WT and 31 genes (upregulation of 12 genes and downregulation of 19 genes) in the 8WT displayed altered gene expression with exercise training. Thus exercise training caused an alteration of many genes expression in the heart and

  • Individual Variations in Exercise Training-induced Physiological Effects and Genetic Factors

    Maeda, Seiji, Murakami, Haruka, Kuno, Shinya, Matsuda, Mitsuo, Murakami, Kazuo

    International Journal of Sport and Health Science   4 ( 2 ) 339 - 347  2006年01月  [査読有り]

     概要を見る

    Regular exercise training brings about desirable physical effects, including an increase in both endurance capacity and muscle strength/volume and an improvement in arterial stiffness that regulate blood pressure. However, these effects vary greatly between individuals. In addition to environmental factors, the genetic backgrounds causing those individual variations are inferred. Research exploring genes which regulate physical capabilities and training-induced effects is widely being implemented. These studies will encourage an individually tailored prescription of lifestyle/exercise for health. This review focused on individual variations of exercise training-induced effects on physical endurance capacity, muscle strength/volume and arterial stiffness. The relation between these effects and the gene and genetic factors, and future perspectives were discussed. Concerning endurance capacity, many studies have been carried out on ACE genotype, and also the relation to polymorphisms of mtDNA, UCP gene or HIF1A gene. In our studies, the polymorphisms of mitochondria-related genes were explored, revealing a suggestion that polymorphism is related to the endurance capacity and the pheno

  • Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts

    Motoyuki Iemitsu, Seiji Maeda, Subrina Jesmin, Takeshi Otsuki, Takashi Miyauchi

    American Journal of Physiology - Heart and Circulatory Physiology   291 ( 3 ) H1290 - H1298  2006年  [査読有り]

     概要を見る

    Exercise training improves aging-induced deterioration of angiogenesis in the heart. However, the mechanisms underlying exercise-induced improvement of capillary density in the aged heart are unclear. Vascular endothelial growth factor (VEGF) is implicated in angiogenesis, which activated angiogenic signaling cascade through Akt and endothelial nitric oxide synthase (eNOS)-related pathway. We hypothesized that VEGF angiogenic signaling cascade in the heart contributes to a molecular mechanism of exercise training-induced improvement of capillary density in old age. With the use of hearts of sedentary young rats (4 mo old), sedentary aged rats (23 mo old), and exercise-trained aged rats (23 mo old, swim training for 8 wk), the present study investigated whether VEGF and VEGF-related angiogenic molecular expression in the aged heart is affected by exercise training. Total capillary density in the heart was significantly lower in the sedentary aged rats compared with the sedentary young rats, whereas that in the exercise-trained rat was significantly higher than the sedentary aged rats. The mRNA and protein expressions of VEGF and of fms-like tyrosine kinase-1 (Flt-1) and fetal liver kinase-1 (Flk-1), which are main VEGF receptors, in the heart were significantly lower in the sedentary aged rats compared with the sedentary young rats, whereas those in the exercise-trained rats were significantly higher than those in the sedentary aged rats. The phosphorylation of Akt protein and eNOS protein in the heart corresponded to the changes in the VEGF protein levels. These findings suggest that exercise training improves aging-induced downregulation of cardiac VEGF angiogenic signaling cascade, thereby contributing to the exercise training-induced improvement of angiogenesis in old age. Copyright © 2006 the American Physiological Society.

    DOI PubMed

  • The subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by the normalization of the upregulated endothelin system in rats

    Subrina, Jesmin, Yuichi, Hattori, Seiji, Maeda, Sohel, Zaedi, Ichiro, Sakuma, Takashi, Miyauchi

    American Journal of Physiology: Heart and Circulatory Physiology   290 ( 5 ) H2146-H2154  2006年01月  [査読有り]

     概要を見る

    We investigated whether benidipine, a long-acting calcium channel blocker (CCB), can normalize cardiac expression profiles of the endothelin (ET)-1 system in insulin-resistant diabetes. Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of human Type 2 diabetes, were treated for 12 wk with vehicle or benidipine (3 mg.kg(-1).day(-1)). OLETF rats exhibited a significant increase in ET-1 in plasma and left ventricular (LV) tissues compared with nondiabetic controls. Expression of prepro-ET-1, ET-converting enzyme, and ET(A) and ET(B) receptors in LV tissues was also significantly higher in OLETF rats. The two MAPKs, JNK and p38MAPK, both of which are activated by ET-1, were more abundantly expressed in OLETF rat LV tissues. All these alterations were reversed to nondiabetic levels when OLETF rats were treated with the subdepressor dose of benidipine. Furthermore, benidipine therapy resulted in hindering cardiomyocyte hypertrophy and cardiac perivascular fibrosis in OLETF rats. The beneficial actions of benidipine at the subdepressor dose on cardiac remodeling in insulin-resistant diabetes may involve normalization of the upregulated ET-1 system.

  • Alterations of gene expressions of preproET-1 and ET receptors in brain of endotoxemia Sprague-Dawley rat

    Nobutake, Shimojo, Subrina, Jesmin, Sohel, Zaedi, Seiji, Maeda, Satoshi, Gando, Iwao, Yamaguchi, Katsutoshi, Goto, Takashi, Miyauchi

    Experimental Biology and Medicine   231   1058-1063  2006年01月  [査読有り]

  • Effects of athletic strength- and aerobic-exercise training in young humans on plasma endothelin-1 concentration and arterial distensibility

    Takeshi, Otsuki, Seiji, Maeda, Motoyuki, Iemitsu, Yoko, Saito, Yuko, Tanimura, Ryuichi, Ajisaka, Katsutoshi, Goto, Takashi, Miyauchi

    Experimental Biology and Medicine   231   789-793  2006年01月  [査読有り]

  • 英文原著論文紹介:閉経後女性の血管拡張性リモデリングが頸動脈コンプライアンスに及ぼす影響

    菅原順, 大槻毅, 前田清司, 田辺匠, 久野譜也, 鰺坂隆一, 松田光生

    Arterial Stiffness   10   86-87  2006年01月

  • AI、PWV、ABIに関するQ&A

    家光素行, 前田清司, 宮地元彦, 田中弘文

    Arterial Stiffness   10   112  2006年01月

  • 運動トレーニングと大動脈における遺伝子プロファイリング ―トレーニングによる大動脈伸展性増大における分子メカニズムの解明―

    前田清司, 家光素行, 宮内卓

    平成16~17年度文部省科学研究費基盤研究C報告書     1-52  2006年01月

  • 抵抗性運動鍛錬者は運動後の心拍数の回復応答が早くなる(Strength-trained athletes cause to acceleration of recovery in heart rate after exercise)

    Otsuki Takeshi, Maeda Seiji, Iemitsu Motoyuki, Saito Yoko, Tanimura Yuko, Ajisaka Ryuichi, Miyauchi Takashi

    Advances in Exercise and Sports Physiology   11 ( 4 ) 181 - 181  2005年12月

  • 間欠的掌握運動時の骨格筋疲労と上腕動脈運動後充血反応の性差(Gender differnces in skeletal muscle fatigability during intermittent handgrip exercise and post-exercise brachial artery hyperemia)

    Saito Yoko, Iemitsu Motoyuki, Otsuki Takeshi, Tanimura Yuko, Maeda Seiji, Ajisaka Ryuichi

    Advances in Exercise and Sports Physiology   11 ( 4 ) 182 - 182  2005年12月

  • Gene expression profiling of exercise-induced cardiac hypertrophy in rats

    M Iemitsu, S Maeda, T Miyauchi, M Matsuda, H Tanaka

    ACTA PHYSIOLOGICA SCANDINAVICA   185 ( 4 ) 259 - 270  2005年12月  [査読有り]

     概要を見る

    Aims: Exercise training causes physiological cardiac hypertrophy, which acts to enhance cardiac function during exercise. However, the underlying molecular mechanisms are unclear. We investigated gene expression profile of exercise training-induced cardiac hypertrophy using left ventricle (LV) excised from exercise-trained and sedentary control rats (12-week old).
    Method: Rats in the training group exercised on a treadmill for 8-week.
    Results: Left ventricular mass index and wall thickness in the exercise-trained group were significantly greater than that in the control group, indicating that the trained rats developed cardiac hypertrophy. Of the 3800 genes analysed in the microarray analyses, a total of 75 relevant genes (upregulation of 33 genes and downregulation of 42 genes) displayed alterations with exercise training. Among these genes, we focused on glycogen synthase kinase (GSK)-3 beta, calcineurin-inhibitor (Cain), and endothelin (ET)-1 for their implicated roles in pathological cardiac hypertrophy, and confirmed the results of microarray analysis at mRNA and protein/peptide levels using quantitative PCR, Western blot, and EIA analyses. The gene expression of GSK-3 beta decreased significantly and those of Cain and ET-1 increased significantly with exercise training. Furthermore, LV mass index was significantly correlated with GSK-3 beta protein activity (r = -0.70, P &lt; 0.01) and tissue ET-1 concentration (r = 0.52, P &lt; 0.05). There were no changes in gene expressions in brain natriuretic peptide (BNP), angiotensin-correcting enzyme (ACE), interleukin-6, and vascular cell adhesion molecule (VCAM)-1.
    Conclusion: These findings suggest that physiological and pathological LV hypertrophy may share some of the same molecular mechanisms in inducing LV hypertrophy (e.g. GSK-3 beta, Cain, and ET-1) and that other genes (e.g. BNP, ACE) may differentiate physiological from pathological LV hypertrophy.

  • 高血圧と血管内皮障害

    前田, 清司, 宮内, 卓

    糖尿病 = Journal of the Japan Diabetes Society   48 ( 12 ) 829 - 831  2005年12月

  • エンドセリンとエンドセリン拮抗薬

    前田, 清司, 宮内, 卓, 後藤, 勝年

    血管   28 ( 4 ) 121 - 132  2005年12月

  • 148.有酸素性運動競技者および抵抗性運動競技者における血漿エンドセリン-1濃度と動脈伸展性(呼吸・循環,一般口演,第60回 日本体力医学会大会)

    大槻, 毅, 前田, 清司, 家光, 素行, 斉藤, 陽子, 谷村, 祐子, 鰺坂, 隆一, 宮内, 卓

    体力科學   54 ( 6 ) 492  2005年12月

  • 134.老齢期からの運動トレーニングによる心臓の毛細血管数低下の改善にVascular Endothelial Growth Factor(VEGF)による分子レベルの改善が関与する(呼吸・循環,一般口演,第60回 日本体力医学会大会)

    家光, 素行, 前田, 清司, サブリナ, ジュスミン, 宮内, 卓

    体力科學   54 ( 6 ) 485  2005年12月

  • エストロゲン受容体α遺伝子多型は中高齢者の動脈stiffnessに影響する : SATプロジェクト179(呼吸・循環,一般口演,第60回 日本体力医学会大会)

    林, 貢一郎, 前田, 清司, 家光, 素行, 大槻, 毅, 菅原, 順, 田辺, 匠, 宮内, 卓, 久野, 譜也, 鰺坂, 隆一, 横井, 孝志, 目崎, 登, 松田, 光生

    体力科學   54 ( 6 ) 478  2005年12月

  • 107.運動と骨関連遺伝子が骨強度に及ぼす影響(運動器,一般口演,第60回 日本体力医学会大会)

    大久保, 寛之, 中田, 由夫, 家光, 素行, 宮内, 卓, 前田, 清司, 田中, 喜代次

    体力科學   54 ( 6 ) 472  2005年12月  [査読有り]

  • 86.骨格筋に性ステロイドホルモン合成経路の酵素が発現する(運動器,一般口演,第60回 日本体力医学会大会)

    相澤, 勝治, 前田, 清司, 家光, 素行, 大槻, 毅, ジュスミン, S, 林, 貢一郎, 宮内, 卓, 目崎, 登

    体力科學   54 ( 6 ) 461  2005年12月

  • 1B-16 Strength-trained athletes cause to acceleration of recovery in heart rate after exercise(Cardiovascular Function, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))

    OTSUKI, Takeshi, MAEDA, Seiji, IEMITSU, Motoyuki, SAITO, Yoko, TANIMURA, Yuko, AJISAKA, Ryuichi, MIYAUCHI, Takashi

    Advances in exercise and sports physiology   11 ( 4 ) 181  2005年12月

  • 1B-12 Exercise training improves age-induced impairment of energy metabolic capacity in mitochondria through PGC-1α in the heart(Cardiovascular Function, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 3

    IEMITSU, Motoyuki, MAEDA, Seiji, MIYAUCHI, Takashi

    Advances in exercise and sports physiology   11 ( 4 ) 180  2005年12月

  • 1B-10 Effects of weight loss on plasma levels of endothelium-derived factors in obese men(Cardiovascular Function, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))

    MAEDA, Seiji, JESMIN, Subrina, IEMITSU, Motoyuki, OTSUKI, Takeshi, NAKATA, Yoshio, TANAKA, Kiyoji, MIYAUCHI, Takashi

    Advances in exercise and sports physiology   11 ( 4 ) 179  2005年12月  [査読有り]

  • 04-26-ダンス-16 青年期における有酸素性および抵抗性の運動競技継続年数と動脈伸展性および左心室の形態的適応(04 運動生理学,一般研究発表)

    大槻, 毅, 前田, 清司, 家光, 素行, 斉藤, 陽子, 谷村, 祐子, 鰺坂, 隆一, 宮内, 卓

    日本体育学会大会予稿集   0 ( 56 ) 238  2005年11月

  • 04-25-53A02-08 老齢期からの運動トレーニングは加齢により亢進した心臓のアポトーシス(細胞死)を改善させる(04 運動生理学,一般研究発表)

    家光, 素行, 前田, 清司, 宮内, 卓

    日本体育学会大会予稿集   0 ( 56 ) 227  2005年11月

  • 04-25-53A02-05 中高齢者における運動トレーニングの血中高感度CRPおよびホモシステイン濃度に対する効果 : SAT Project No.183(04 運動生理学,一般研究発表)

    鰺坂, 隆一, 大槻, 毅, 村上, 晴香, 前田, 清司, 久野, 譜也

    日本体育学会大会予稿集   0 ( 56 ) 226  2005年11月

  • 04-24-53A02-09 運動は骨格筋局所の性ステロイドホルモン代謝関連酵素を活性化させる(04 運動生理学,一般研究発表)

    相澤, 勝治, 前田, 清司, 家光, 素行, 大槻, 毅, 宮内, 卓, 目崎, 登

    日本体育学会大会予稿集   0 ( 56 ) 219  2005年11月

  • Aortic stiffness and aerobic exercise: Mechanistic insight from microarray analyses

    S Maeda, M Iemitsu, T Miyauchi, S Kuno, M Matsuda, H Tanaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   37 ( 10 ) 1710 - 1716  2005年10月  [査読有り]

     概要を見る

    Introduction/Purpose: Regular aerobic exercise reduces aortic stiffness. However, the mechanisms by which chronic exercise lowers arterial stiffness are not known. To determine the molecular mechanisms of these changes, the alteration of gene expression in the aorta by aerobic exercise training was measured with the microarray technique. Methods/Results: The differences in expression levels of 3800 genes in the abdominal aorta of sedentary control rats (8 wk old) and exercise-trained rats (8 wk old, treadmill running for 4 wk) were compared by the microarray analysis. Aortic pulse wave velocity (PWV) was lower and systemic arterial compliance was higher (both P &lt; 0.05) in the exercise-trained group than in the control group. Of the 323 genes that displayed differential expression (upregulation of 206 genes and downregulation of 117 genes), a total of 29 genes (24 upregulated and 5 downregulated genes) were identified as potential candidate genes that may be involved in vasodilation and arterial destiffening. Using real-time quantitative polymerase chain reaction, we confirmed the results of microarray analysis that prostaglandin EP2 receptor (PGE-EP2R), prostaglandin EP4 receptor (PGE-EP4R), C-type natriuretic peptide (CNP), and endothelial nitric oxide synthase (eNOS) genes were differentially expressed. Furthermore, there were modest correlations between arterial stiffness and levels of these factors. Differential expression of eNOS gene was further verified at protein level by using Western blot analysis. Conclusion: These results suggest that exercise training induces the altered expression in several genes including prostaglandin, CNP, and nitric oxide in the aorta and that these molecular changes (particularly eNOS as its protein expression was altered) may contribute, at least in part, to the beneficial effect of exercise training on aortic stiffness.

    DOI

  • Acute exercise causes an enhancement of tissue renin-angiotensin system in the kidney in rats

    S Maeda, M Iemitsu, S Jesmin, T Miyauchi

    ACTA PHYSIOLOGICA SCANDINAVICA   185 ( 1 ) 79 - 86  2005年09月  [査読有り]

     概要を見る

    Aims: Initially, the renin-angiotensin system (RAS) produced through the classical endocrine pathway was well known for its regulation of blood pressure. However, it was revealed that a local autocrine and/or paracrine RAS may exist in a number of tissues (such as kidney). Exercise causes a redistribution of tissue blood flow, by which the blood flow is greatly increased in active muscles, whereas it is decreased in the splanchnic circulation (such as in the kidney). We hypothesized that exercise causes an enhancement of tissue RAS in the kidney.
    Methods: We studied whether exercise affects expression of angiotensinogen and angiotensin-converting enzyme (ACE) and tissue angiotensin II level in the kidney. The rats performed treadmill running for 30-min. Immediately after this exercise, kidney was quickly removed. Control rats remained at rest during this 30-min period.
    Results: The expression of angiotensinogen mRNA in the kidney was markedly higher in the exercise rats than in the control rats. ACE mRNA in the kidney was significantly higher in the exercise rats than in the control rats. Western blot analysis confirmed significant upregulation of ACE protein in the kidney after exercise. Tissue angiotensin II level was also increased by exercise.
    Conclusion: The present study suggests that the exercise-induced enhancement of tissue RAS in the kidney causes vasoconstriction and hence decreases blood flow in the kidney, which are helpful in increasing blood flow in active muscles, thereby contributing to the redistribution of blood flow during exercise.

  • Effects of aerobic exercise training on the stiffness of central and peripheral arteries in middle-aged sedentary men

    K Hayashi, J Sugawara, H Komine, S Maeda, T Yokoi

    JAPANESE JOURNAL OF PHYSIOLOGY   55 ( 4 ) 235 - 239  2005年08月  [査読有り]

     概要を見る

    Aortic pulse wave velocity (PWV) significantly decreased after 16 weeks of moderate-intensity exercise training (walking/jogging) in 17 sedentary middle-aged men, whereas leg PWV did not. These results suggest that in contrast with central arterial stiffness, peripheral arterial stiffness is difficult to change with aerobic exercise training.

    DOI

  • Effect of arterial lumen enlargement on carotid arterial compliance in normotensive postmenopausal women

    J Sugawara, T Otsuki, S Maeda, T Tanabe, S Kuno, R Ajisaka, M Matsuda

    HYPERTENSION RESEARCH   28 ( 4 ) 323 - 329  2005年04月  [査読有り]

     概要を見る

    A reduction in central arterial compliance has been identified as an independent risk factor for future cardiovascular disease. The aim of the present study was to determine the influence of age-related carotid arterial enlargement on carotid arterial compliance in postmenopausal females, using a cross-sectional study design. Carotid arterial properties were measured with applanation tonometry and ultrasound system in 113 normotensive females (aged 50-78). Brachial-ankle pulse wave velocity (baPWV) measured by a plethysmographic technique was used as an index of arterial stiffness. In comparisons among the three age groups (50-59, 60-69, and 70-78 years old), baPWV (F=11.9, p &lt; 0.001) and carotid systolic (F=4.5, p &lt; 0.05) and pulse pressures (F=9.6, p &lt; 0.0001), and lumen diameter (F=5.6, p &lt; 0.01) increased with advancing age. Carotid arterial compliance gradually decreased with age, but not significantly. A stepwise regression analysis revealed that carotid systolic pressure and lumen diameter and age were independent correlates of carotid arterial compliance. After carotid lumen diameter was taken into account (ANCOVA), the differences in carotid arterial compliance among the three age groups became significant (F=3.8, p &lt; 0.05). These results suggest that an increase in arterial lumen diameter might compensate for the age-related increase in arterial stiffness and limit the deterioration of the buffering capacity of the central artery in normotensive postmenopausal females.

  • Aortic Stiffness and Habitual Exercise : Molecular Mechanistic Insight (Exercise Test/Cardiac Rehabilitation 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Maeda, Seiji, Iemitsu, Motoyuki, Miyauchi, Takashi, Yamaguchi, Iwao, Matsuda, Mitsuo

    Circulation journal : official journal of the Japanese Circulation Society   69 ( 0 ) 643 - 644  2005年03月

  • Time-course Change of MAPK Signaling Pathways in the Heart during Exercise and Post-exercise (Cardiac Hypertrophy, Basic (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Iemitsu, Motoyuki, Maeda, Seiji, Matsuda, Mitsuo, Miyauchi, Takashi, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   69 ( 0 ) 587  2005年03月

  • Gene Expression Profiling of Exercise Training-induced Physiological Cardiac Hypertrophy in the Rats(Exercise Test/Cardiac Rehabilitation 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Iemitsu, Motoyuki, Maeda, Seiji, Miyauchi, Takashi, Matsuda, Mitsuo, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   69 ( 0 ) 293  2005年03月

  • 運動トレーニングによる心臓の適応メカニズム:遺伝子レベルから

    家光, 素行, 前田, 清司, 宮内, 卓

    筑波大学体育科学系紀要   28 ( 0 ) 31 - 41  2005年03月

     概要を見る

    近年、国内外で心臓・血管疾病による死亡率が増加している。その原因として、高血圧症、高脂肪血症、糖尿病などの生活習慣病の急増が問題視されており、継続的な運動はこれらの予防や改善に対して、極めて有効な手段とされている。 ...

  • Effects of short-term endurance training on aortic distensibility in young males

    T Kakiyama, J Sugawara, H Murakami, S Maeda, S Kuno, M Matsuda

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   37 ( 2 ) 267 - 271  2005年02月  [査読有り]

     概要を見る

    KAKIYAMA, T., J. SUGAWARA, H. MURAKAMI, S. MAEDA, S. KUNO, and M. MATSUDA. Effects of Short-Term Endurance Training on Aortic Distensibility in Young Males. Med. Sci. Sports Exerc., Vol. 37, No. 2, pp. 267-271, 2005. Background: Short-term endurance exercise training can increase aortic distensibility. The effect of exercise on arterial distensibility, however, may not last long term. Purpose: We evaluated the effects of short-term exercise training and detraining on aortic distensibility in 10 sedentary young males (21.0 +/- 0.6 yr. mean +/- SE; range 19-24 yr). Methods: The subjects underwent 8 wk of endurance training on a cycle ergometer at 70% of maximal oxygen consumption (VO2max), for 60 min at a time and on alternate days (3-4 d(.)wk(-1)). The detraining period consisted of a return to sedentary days for 8 wk. The aortic pulse wave velocity (APWV) was measured before and immediately after training and during the detraining period. Results: The VO2max was significantly increased after training (pre: 2240.0 +/- 71.4 mL, after: 2729.9 +/- 82.5 mL, mean +/- SE, P &lt; 0.0001) and remained at increased levels during the detraining period (after 4 wk: 2671.2 +/- 73.6 mL, P &lt; 0.001; after 8 wk: 2628.0 +/- 85.0 mL, P &lt; 0.001). The APWV was significantly decreased after training (pre: 5.80 +/- 0.15 m(.)s(-1), after: 5.50 +/- 0.21 m-s(-1), P &lt; 0.01) but returned close to the baseline after detraining for 4 wk (5.66 +/- 0.13 m(.)s(-1), P &lt; 0.18). Conclusion: Our data suggest that short-term exercise training can improve aortic distensibility, but the effect cannot be maintained without continuing physical exercise.

    DOI

  • Time Dependent Alterations of Endothelin System in Lungs of Endotoxemia.Proceeding of Joint Congress of The Histochemical Society (USA) and the Society for Histochemistry (Europe)

    Shimojo, N, Jesmin, S, Zaedi, S, Masuzawa, K, Mowa, C.N, Maeda, S, Gando, S, Miyauchi, T

    Journal of Histochemistry and Cytochemistry    2005年  [査読有り]

  • 脳卒中の予防という視点からみた動脈伸展性と運動効果の個人差を規定する遺伝的要因

    松田光生, 前田清司

    文部科学省科学技術振興調整費「高齢者の生活機能の維持・増進と社会参加を促進する地域システムに関する研究」報告書     165-173  2005年01月

  • 高血圧・動脈硬化を予防・抑制するための健康状態の指標化と至適運動プログラムの開発

    松田光生, 前田清司

    文部科学省科学技術振興調整費「高齢者の生活機能の維持・増進と社会参加を促進する地域システムに関する研究」報告書     86-100  2005年01月

  • Moderate regular exercise increases basal production of nitric oxide in elderly women

    S Maeda, T Tanabe, T Tsuk, J Sugawara, M Iemitsu, T Miyauchi, S Kuno, R Ajisaka, M Matsuda

    HYPERTENSION RESEARCH   27 ( 12 ) 947 - 953  2004年12月

     概要を見る

    Vascular endothelial cells produce nitric oxide (NO), which is a potent vasodilator substance and is thought to have antiatherosclerotic properties. Therefore, it has also been proposed that NO may be useful to regulate vascular tonus and prevent progression of atherosclerosis. On the other hand, NO activity reduces with aging. We previously reported that the plasma nitrite/nitrate (NOx: the stable end product of NO) concentration was significantly increased by intense aerobic exercise training in healthy young humans. We hypothesized that lifestyle modification (e.g., even mild regular exercise training) can increase NO production in previously sedentary older humans. We measured the plasma NOx concentration before and after a mild aerobic exercise training regimen (cycling on a leg ergometer at 80% ventilatory threshold for 30 min, 5 days/week) for 3 months in elderly women. In addition, we assessed the plasma concentration of cyclic guanosine monophosphate (cGMP), a second messenger of NO, in the same samples. The individual ventilatory threshold increased significantly after the 3-month exercise training. The blood pressure at rest significantly decreased after exercise training. These results suggest that the 3-month exercise training in the older women produced favorable physiological effects. The plasma concentration of NOx significantly increased by the exercise training, and the plasma concentration of cGMP also increased by the exercise training. The present study suggests that even a mild regular aerobic-endurance exercise increases NO production in previously sedentary older humans, which may have beneficial effects (Le., anti hypertensive and antiatherosclerotic effects by endogenous NO) on the cardiovascular system.

  • Effects of nitric oxide synthase inhibitor on decrease in peripheral arterial stiffness with acute low-intensity aerobic exercise

    J Sugawara, S Maeda, T Otsuki, T Tanabe, R Ajisaka, M Matsuda

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   287 ( 6 ) H2666 - H2669  2004年12月  [査読有り]

     概要を見る

    We previously reported that even low-intensity, short-duration acute aerobic exercise decreases arterial stiffness. We aimed to test the hypothesis that the exercise-induced decrease in arterial stiffness is caused by the increased production of NO in vascular endothelium with exercise. Nine healthy men (age: similar to22-28 yr) performed a 5-min single-leg cycling exercise ( 30 W) in the supine position under an intravenous infusion of N-G-monomethyl-L-arginine (L-NMMA; 3 mg/kg during the initial 5 min and subsequent continuous infusion of 50 mug . kg(-1) . min(-1) in saline) or vehicle (saline) in random order on separate days. The pulse wave velocity (PWV) from the femoral to posterior tibial artery was measured on both legs before and after the infusion at rest and 2 min after exercise. Under the control condition, exercised leg PWV significantly decreased after exercise (P &lt; 0.05), whereas nonexercised leg PWV did not show a significant change throughout the experiment. Under L-NMMA administration, exercised leg PWV was increased significantly by the infusion (P &lt; 0.05) but decreased significantly after the exercise (P &lt; 0.05). Nonexercised leg PWV increased with L-NMMA administration and maintained a significantly higher level during the administration compared with baseline ( before the infusion, all P &lt; 0.05). The NO synthase blockade x time interaction on exercised leg PWV was not significant (P = 0.706). These results suggest that increased production of NO is not a major factor in the decrease of regional arterial stiffness with low-intensity, short-duration aerobic exercise.

    DOI

  • 間欠的掌握運動後の筋力の回復動態の性差と筋の酸素化動態の関係 : 近赤外分光法による検討(加齢・性差, 第59回日本体力医学会大会)

    斉藤, 陽子, 大槻, 毅, 田辺, 匠, 黒石, 祐子, 久野, 譜也, 前田, 清司, 鯵坂, 隆一

    体力科學   53 ( 6 ) 773  2004年12月

  • 動脈伸展性が低下すると運動時の心筋酸素摂取量は増大する : SATプロジェクト140(呼吸・循環, 第59回日本体力医学会大会)

    大槻, 毅, 気仙, 有実子, 菅原, 順, 横山, 典子, 田辺, 匠, 宮内, 卓, 前田, 清司, 久野, 譜也, 鰺坂, 隆一, 松田, 光生

    体力科學   53 ( 6 ) 714  2004年12月

  • 8週間の筋力トレーニングがヒト血中エンドセリン-1濃度に及ぼす影響(呼吸・循環, 第59回日本体力医学会大会)

    前田, 清司, 家光, 素行, 菅原, 順, 宮内, 卓

    体力科學   53 ( 6 ) 713  2004年12月

  • 554.一過性運動による心臓のmitogen-activated protein kinase活性の経時的変化(呼吸・循環)

    家光, 素行, 前田, 清司, 宮内, 卓

    体力科學   53 ( 6 ) 910  2004年12月

  • O-4 Time-course alterations of expression of immediate early gene in the heart during exercise and postexercise(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)

    IEMITSU, Motoyuki, MAEDA, Seiji, MIYAUCHI, Takashi

    Advances in exercise and sports physiology   10 ( 4 ) 118  2004年12月

  • Chronic administration of an endothelin-A receptor antagonist improves exercise capacity in rats with myocardial infarction-induced congestive heart failure

    T Miyauchi, A Fujimori, S Maeda, M Iemitsu, S Sakai, H Shikama, T Tanabe, M Matsuda, K Goto, Yamaguchi, I

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   44 ( Suppl. 1 ) S64 - S67  2004年11月  [査読有り]

     概要を見る

    The effects of long-term administration of YM598, a selective endothelin-A antagonist, on improving the exercise tolerance of chronic heart failure model rats were examined using a treadmill exercise loading test. Rats were acclimatized to the treadmill apparatus and the coronary artery was ligated to prepare a myocardial infarction-induced congestive heart failure (CHF) model. Starting 10 days postoperatively, when the acute phase of infarction was over, YM598 was administered orally once daily for approximately 25 weeks at a dose of 1 mg/kg. At weeks 20 and 24 the treadmill test was performed. YM598 prolonged running tune, which had been shortened as a result of heart failure. The weights, relative to the body weight, of the left and right ventricles and lungs of surviving rats with CHF were significantly greater than those of sham-operated rats, suggesting hypertrophy of the ventricles and congestion of the lungs. Administration of YM598 markedly reduced ventricular hypertrophy and pulmonary congestion. Examination of cardiac function revealed that, in surviving CHF rats, the peak positive first derivative of left ventricular pressure was significantly lower, and left ventricular end-diastolic pressure, right ventricular systolic pressure and central venous pressure were significantly higher in comparison to sham-operated rats. These data demonstrate that, in rats with CHF, the contractile and diastolic capacity of the left ventricle decreased and pulmonary hypertension and systemic congestion occurred. Long-term administration of YM598 improved left ventricular function of CHF rats to the level of sham-operated rats, and reduced the workload placed on the right side of the heart. Histological examination revealed that long-term treatment with YM598 prevented fibrosis of the surviving left ventricular myocardium. In conclusion, long-term administration of YM598 to rats with CHF improved exercise tolerance and inhibited remodeling of cardiac muscles, leading to marked improvement of cardiac function.

  • Effects of medium-chain triglyceride (MCT) application to SHR on cardiac function, hypertrophy and expression of endothelin-1 mRNA and other genes.

    Nobutake Shimojo, Takashi Miyauchi, Motoyuki Iemitsu, Yoko Irukayama-Tomobe, Seiji Maeda, Takeshi Ohkubo, Yukihisa Tanaka, Katsutoshi Goto, Iwao Yamaguchi

    Journal of cardiovascular pharmacology   44 Suppl 1 ( Suppl. 1 ) S181-5 - 0  2004年11月  [査読有り]  [国際誌]

     概要を見る

    In spontaneously hypertensive rats a decrease occurs in myocardial energy supply from long-chain triglyceride (LCT) by CD36 gene mutation-induced dysfunction. We investigated whether long-term intake of medium-chain triglyceride, which enters into cells without CD36, upregulates fatty acid metabolic capacity in the heart of spontaneously hypertensive rats, and whether this upregulation improves cardiac hypertrophy and molecular markers. Male 4-week-old spontaneously hypertensive rats were given medium-chain triglyceride (SHR-MCT) or LCT (SHR-LCT) for 16 weeks. After hemodynamic measurement, we determined myocardial fatty acid metabolic enzyme activity and mRNA expression of molecular markers (endothelin-1, alpha-skeletal actin, angiotensin-converting enzyme and brain natriuretic peptide) for cardiac hypertrophy. We used Wistar-Kyoto rats (WKY-MCT and WKY-LCT) as controls. When compared with SHR-LCT rats, SHRMCT rats showed an increase in myocardial fatty acid metabolic enzyme activity and improvement in cardiac function (left ventricular end-diastolic pressure and +dP/dt/P) and cardiac hypertrophy. Blood pressure did not differ between them. The mRNA expression of endothelin-1, alpha-skeletal actin, angiotensin-converting enzyme and brain natriuretic peptide in the heart was significantly higher in SHR-LCT than in WKY-MCT and WKYLCT rats, and there was no significant difference between SHRLCT and SHR-MCT. These findings suggest that medium-chain triglyceride application to spontaneously hypertensive rats improves decreased cardiac function and cardiac hypertrophy without affecting blood pressure and myocardial mRNA expression of molecular markers. Because mechanical stress to the heart is similar between SHR-LCT and SHR-MCT, this may be a reason for the lack of difference in expression of molecular markers.

    PubMed

  • Exercise-induced tissue-specific change in gene expression of endothelin-1

    S Maeda, M Iemitsu, T Miyauchi, K Goto

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   44 ( Suppl. 1 ) S336 - S340  2004年11月  [査読有り]

     概要を見る

    Exercise causes an integrated physiological response (e.g., an increase in cardiac output and a significant redistribution of tissue blood flow), which greatly increases blood flow in active muscles but decreases it in the splanchnic circulation. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by vascular endothelial cells. We hypothesized that exercise causes a tissue-specific change in ET-1 production in various organs. We studied whether a bout of exercise alters the expression of preproET-1 mRNA in various tissues of rats. The rats were randomly divided into exercise rats and control rats. Exercise rats performed treadmill running for 30 minutes at a speed of 30 m/minute. Control rats remained at rest during the same period (30 minutes). Immediately after the exercise and rest, the abdominal artery, liver, muscles (tibialis anterior muscle, plantar muscle and soleus) and adipose tissue were quickly removed and the expression of preproET-1 mRNA in these tissues was determined by real-time quantitative polymerase chain reaction analysis. The expression of preproET-1 mRNA in these tissues was changed in a different manner by acute exercise (i.e., increased, decreased, or unchanged). The expression of preproET-1 mRNA in the aorta was significantly decreased by exercise, whereas that in the plantar muscle was significantly increased by exercise. There were no significant differences in the expression of preproET-1 mRNA in the liver, tibialis anterior muscle, soleus and adipose tissue between the exercise rats and the control rats. These results show that the expression of preproET-1 mRNA was changed tissue-specifically by acute exercise. We demonstrate that acute exercise causes tissue-specific changes in the production of ET-1 and that these alterations may participate in the integrated physiological response during exercise.

  • Resistance exercise training reduces plasma endothelin-1 concentration in healthy young humans

    S Maeda, T Miyauchi, M Iemitsu, J Sugawara, Y Nagata, K Goto

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   44 ( Suppl. 1 ) S443 - S446  2004年11月  [査読有り]

     概要を見る

    Endothelin-1 (ET-1), which is produced by vascular endothelial cells, has potent vasoconstrictor and proliferative activity in vascular smooth muscle cells, and therefore has been implicated in regulation of vascular tonus and progression of atherosclerosis. We recently demonstrated that the plasma ET-1 concentration was significantly decreased by aerobic exercise training in healthy young humans and healthy older humans. However, it is unclear whether the production of ET-1 is altered by resistance exercise training. We measured the plasma ET-1 concentration before and after resistance exercise training in healthy young humans. Six healthy young men (26 +/- 1 years old) performed 8 weeks of resistance exercise training (3 days/week). There were no significant differences in body composition, blood pressure, heart rate, and maximal oxygen consumption before and after resistance exercise training. The girths of the arm and thigh significantly increased after resistance exercise training. The maximal muscle powers in the arm and leg increased after resistance exercise training. After resistance exercise training, the plasma concentration of ET-1 significantly decreased. The present study suggested that resistance exercise training, as well as aerobic exercise training, reduces the plasma ET-1 concentration in healthy young humans, and that this reduction in plasma ET-1 concentration may have beneficial effects on the cardiovascular system.

  • Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats

    M Iemitsu, T Miyauchi, S Maeda, M Matsuda, K Goto, Yamaguchi, I

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   44 ( Suppl. 1 ) S447 - S450  2004年11月

     概要を見る

    Endothelin-1 (ET-1) is produced by endothelial cells and cardiac myocytes. ET-1 has potent positive inotropic and chronotropic effects in the heart and causes myocardial cell hypertrophy. We investigated the alteration of gene expression of ET-1 in the heart of rats during acute exercise and 24 hour post-exercise periods. Sprague-Dawley rats performed treadmill running for 30 minutes at a speed of 30 m/minute. We determined the expression ofpreproendothelin-1 mRNA in the rat hearts of resting (control) and 0, 0.5, 1, 3, 6, 12, and 24 hour post-exercise time points, respectively. The percent changes in expression of preproendothelin-1 mRNA in the heart from resting control rats were significantly increased at the time point of 1 hour post-exercise (199.0 +/- 33.6%, P &lt; 0.05), and this enhancement returned to the level of resting control rats at the time points of 6, 12, and 24 hours post-exercise. These results suggest that a bout of exercise causes time-related enhancement of gene expression of ET-1 in the rat hearts during acute exercise and 24 hour post-exercise periods. Therefore, an exercise-induced change of ET-1 gene expression in the heart may participate in mechanisms of exercise-induced and/or training-induced adaptive responses of the heart.

  • 045T60104 70代の高齢者における低強度の有酸素性トレーニングが動脈系コンプライアンスに及ぼす影響 : SATプロジェクト149(04.運動生理学,一般研究発表)

    大槻, 毅, 村上, 晴香, 田辺, 匠, 宮内, 卓, 前田, 清司, 久野, 譜也, 松田, 光生

    日本体育学会大会号   0 ( 55 ) 279  2004年09月

  • 045S20307 中高年齢者における動脈伸展性と食塩摂取量の関連に身体活動が及ぼす影響 : SATプロジェクト168(04.運動生理学,一般研究発表)

    田辺, 匠, 前田, 清司, 大槻, 毅, 久野, 譜也, 松田, 光生

    日本体育学会大会号   0 ( 55 ) 273  2004年09月

  • 045S20306 一過性運動と大動脈における遺伝子プロファイリング(04.運動生理学,一般研究発表)

    前田, 清司, 家光, 素行, 宮内, 卓, 田辺, 匠, 久野, 譜也, 松田, 光生

    日本体育学会大会号   0 ( 55 ) 272  2004年09月

  • 045S20304 一過性運動における心臓の遺伝子プロファイリング(04.運動生理学,一般研究発表)

    家光, 素行, 前田, 清司, 宮内, 卓, 田辺, 匠, 松田, 光生

    日本体育学会大会号   0 ( 55 ) 266  2004年09月

  • Modelflow法による運動中の高齢者の心拍出量測定の妥当性

    菅原, 順, 大槻, 毅, 家光素行, 永田可彦, 田辺, 匠, 本間, 覚, 前田清司, 鰺坂隆一, 松田光生

    日本臨床スポーツ医学会誌   12 ( 3 ) 516-519  2004年09月  [査読有り]

  • Exercise training improves cardiac function-related gene levels through thyroid hormone receptor signaling in aged rats

    M Iemitsu, T Miyauchi, S Maeda, T Tanabe, M Takanashi, M Matsuda, Yamaguchi, I

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   286 ( 5 ) H1696 - H1705  2004年05月  [査読有り]

     概要を見る

    Exercise training improves the aging-induced downregulation of myosin heavy chain (MHC) and sarcoplasmic reticulum (SR) Ca(2+)-ATPase, which participate in the regulation of cardiac contraction and relaxation. Thyroid hormone receptor (TR), a transcriptional activator, affected the regulation of gene expression of MHC and SR Ca(2+)-ATPase. We hypothesized that myocardial TR signaling contributes to a molecular mechanism of exercise training-induced improvement of MHC and SR Ca(2+)-ATPase genes with cardiac function in old age. We investigated whether TR signaling and gene expression of MHC and SR Ca(2+)-ATPase in the aged heart are affected by exercise training, using the hearts of sedentary young rats (4 mo old), sedentary aged rats (23 mo old), and trained aged rats (23 mo old, swimming training for 8 wk). Trained aged rats showed improvement in cardiac function. Expression of TR-alpha(1) and TR-beta(1) proteins in the heart were significantly lower in sedentary aged rats than in sedentary young rats and were significantly higher in trained aged rats than in sedentary aged rats. The activity of TR DNA binding to the transcriptional regulatory region in the alpha-MHC and SR Ca(2+)-ATPase genes and the mRNA and protein expression of alpha-MHC and SR Ca(2+)-ATPase in the heart and plasma 3,3&apos;-triiodothyronine and thyroxine levels were altered in association with changes in the myocardial TR protein levels. These findings suggest that exercise training improves the aging-induced downregulation of myocardial TR signaling-mediated transcription of MHC and SR Ca(2+)-ATPase genes, thereby contributing to the improvement of cardiac function in trained aged hearts.

    DOI

  • Endothelin receptor antagonist reverses decreased NO system in the kidney in vivo during exercise

    S Maeda, T Miyauchi, M Iemitsu, T Tanabe, K Goto, Yamaguchi, I, M Matsuda

    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM   286 ( 4 ) E609 - E614  2004年04月  [査読有り]

     概要を見る

    Vascular endothelial cells produce endothelin (ET)-1, a potent vasoconstrictor peptide, and nitric oxide ( NO), a potent vasodilator substance. There are interactions between ET-1 and NO. Exercise results in a marked decrease in renal blood flow. We previously reported that exercise causes an increase of ET-1 production in the kidney, whereas production of NO in the kidney is decreased. Furthermore, we recently revealed that the magnitude of decrease in blood flow to the kidney during exercise was significantly attenuated by the administration of the endothelin-A (ETA) receptor antagonist, strongly suggesting that endogenously increased ET-1 participates in the decrease of blood flow in the kidney during exercise. Because it was demonstrated that ET-1 depresses NO synthase (NOS) activity of cultured cells in vitro, we hypothesized that an increase of ET-1 production in kidney during exercise contributes to a decrease of NO production in kidney in vivo. We studied whether administration of the ETA receptor antagonist attenuates the decreases of NOS activity and NO production in the kidney during exercise. Rats performed treadmill running for 30 min after pretreatment with an ETA receptor antagonist ( TA-0201, 0.5 mg/kg; TA-0201-treated exercise group) or vehicle (vehicle-treated exercise group). Control rats remained at rest ( vehicle-treated sedentary group). Blood flow in the kidney was decreased by this exercise, but the magnitude of the decrease after pretreatment with TA-0201 was significantly smaller than that after pretreatment with vehicle. NOS activity in kidney was significantly lower in the vehicle-treated exercise group than in the vehicle-treated sedentary group, whereas that in the TA-0201-treated exercise group was significantly higher than that in the vehicle-treated exercise group. Expressions of endothelial NOS protein and NOx, the stable end product of NO, i.e., nitrite/nitrate, concentration in the kidney were significantly lower in the vehicle-treated exercise group than in the vehicle-treated sedentary group, whereas those in the TA-0201-treated exercise group were significantly higher than those in the vehicle-treated exercise group. The data suggest that increased ET-1 production in the kidney during exercise contributes to the decreases of NOS activity and NO production. Therefore, the present study provides a possibility that the exercise-induced increase in production of ET-1 in the kidney causes a decrease in blood flow in the kidney through two pathways, i.e., vasoconstrictive action and the action of attenuating NO production.

    DOI

  • 中高齢者における身体活動が動脈系コンプライアンスおよび収縮期血圧に及ぼす影響

    田辺, 匠, 前田, 清司, 菅原, 順, 大槻, 毅, 柿山, 哲治, 横山, 典子, 宮内, 卓, 久野, 譜也, 鯵坂, 隆一, 松田, 光生

    体育學研究   49 ( 2 ) 135 - 146  2004年03月  [査読有り]

     概要を見る

    The distensibility of the arterial wall progressively decreases with age, and the aging of the arterial wall may be responsible for the decrease of central arterial compliance and the consequent rise of systolic blood pressure (SBP) in the elderly. We hypothesized that an increase in daily physical activity (DPA) might have a favorable effect on systemic arterial compliance (SAC : an index of central arterial compliance) and lower SBP in the elderly. We therefore investigated relationships among DPA, SAC and SBP cross-sectionally in 92 middle-aged and elderly individuals (30 males, 62 fe- males ; aged 64 ± 8 years, mean ± SD). DPA was estimated by using an accelerometer as expended calories. SAC was calculated from the finger pulse pressure waveform recorded by using a Portapres and the stroke volume obtained from the same pressure waveform based on the volume-clamp method. Preliminarily in 37 subjects (17 male, 20 females ; aged 25-97 years), we confirmed a significant negative correlation between the simultaneously measured SAC and aortic pulse wave velocity (r=-0.68, p<0.0001). Correlation analysis and path analysis applied to the hypothetical model demonstrated that SBP was d

  • PJ-380 Effects of Medium-chain Triglyceride (MCT) Application to SHR on Myocardial Energy Metabolic Capacity, Cardiac Function, and Cardiac Hypertrophy(Metabolism/Biochemistry/Energetics 2 (IHD) : PJ64)(Poster Session (Japanese))

    Iemitsu, Motoyuki, Miyauchi, Takashi, Shimojyoh, Nobutake, Irukayama-Tomobe, Yoko, Maeda, Seiji, Ohkubo, Takeshi, Tanaka, Yukihisa, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   68 ( 0 ) 573  2004年03月

  • OE-044 Total Plasma Homocysteine, Exercise Hyperemia, and Aerobic Exercise Capacity in the Middle-aged or Elderly People(Exercise Test/Cardiac Rehabilitation 1 (IHD) : OE6)(Oral Presentation (English))

    Ajisaka, Ryuichi, Matsuda, Mitsuo, Maeda, Seiji, Kuno, Shin-ya, Watanabe, Shigeyuki, Yamaguchi, Iwao

    Circulation journal : official journal of the Japanese Circulation Society   68 ( 0 ) 152  2004年03月

  • 中高年者の生活機能を表す新しい体力・健康スケール:遺伝子からみたスケール〜運動と遺伝子〜

    前田清司, 家光素行

    体育の科学   54   185-190  2004年

  • 1. スポーツ心臓の形成過程における心臓のエンドセリン-1産生の変動(第131回日本体力医学会関東地方会)

    家光, 素行, 前田, 清司, 宮内, 卓

    体力科學   53 ( 5 ) 590 - 599  2004年

    DOI

  • Time course alteration of endothelin-1 gene expression in the heart during exercise and 24-h postexercise periods in rats

    Motoyuki, Iemitsu, Takashi, Miyauchi, Seiji, Maeda, Mitsuo, Matsuda, Katsutoshi, Goto, Iwao, Yamaguchi

    Journal of Cardiovascular Pharmacology   44 ( Suppl 1 ) S447 - S450  2004年01月  [査読有り]

     概要を見る

    Endothelin-1 (ET-1) is produced by endothelial cells and cardiac myocytes. ET-1 has potent positive inotropic and chronotropic effects in the heart and causes myocardial cell hypertrophy. We investigated the alteration of gene expression of ET-1 in the heart of rats during acute exercise and 24 hour postexercise periods. Sprague-Dawley rats performed treadmill running for 30 minutes at a speed of 30 m/minute. We determined the expression of preproendothelin-1 mRNA in the rat hearts of resting (control) and 0, 0.5, 1, 3, 6, 12, and 24 hour post-exercise time points, respectively. The percent changes in expression of preproendothelin-1 mRNA in the heart from resting control rats were significantly increased at the time point of 1 hour post-exercise (199.0 +/- 33.6%, P < 0.05), and this enhancement returned to the level of resting control rats at the time points of 6, 12, and 24 hours post-exercise. These results suggest that a bout of exercise causes time-related enhancement of gene expression of ET-1 in the rat hearts during acute exercise and 24 hour post-exercise periods. Therefore, an exercise-induced change of ET-1 gene expression in the heart may participate in mechanisms of ex

  • 原著論文紹介:一過性の低強度片脚運動が末梢動脈スティフネすに及ぼす影響

    菅原順, 大槻毅, 田辺匠, 前田清司, 久野譜也, 鰺坂隆一, 松田光生

    Arterial Stiffness   6   38-39  2004年01月

  • 動脈系伸展性に及ぼす身体活動の効果:後期高齢者における横断的および縦断的検討

    松田光生, 前田清司, 鰺坂隆一, 宮内卓

    平成14~15年度文部省科学研究費基盤研究B報告書     1-133  2004年01月

  • マウス・ラットからヒトへ -運動効果に関する新しい遺伝子の探索-

    曽根博仁, 叙森, 前田清司, 家光素行, 宮内卓, 松田光生, 山田信博

    地域の中高齢者における生活機能増進法の具体策     66-67  2004年01月

  • 中心動脈伸展性の加齢変化を改善する運動プログラム

    松田光生, 前田清司, 柿山哲治, 菅原順, 大槻毅, 田辺匠, 家光素行

    地域の中高齢者における生活機能増進法の具体策     48-49  2004年01月

  • 中心動脈伸展性の加齢変化と身体活動

    松田光生, 前田清司, 柿山哲治, 菅原順, 大槻毅, 田辺匠

    地域の中高齢者における生活機能増進法の具体策     12-13  2004年01月

  • 動脈伸展性と運動の効果の個人差

    前田清司, 宮地元彦, 家光素行, 菅原順, 大槻毅, 高橋康輝, 山崎健, 田辺匠, 松田光生

    地域の中高齢者における生活機能増進法の具体策     64-65  2004年01月

  • 動脈系コンプライアンスを評価するための簡便で非侵襲的な動脈血圧波形の記録法 : 若年成人において末梢動脈血圧波形を用いる方法の妥当性

    大槻, 毅, 菅原, 順, 田辺, 匠, 前田, 清司, 鰺坂, 隆一, 松田, 光生

    日本臨床スポーツ医学会誌 = The journal of Japanese Society of Clinical Sports Medicine   12 ( 1 ) 41 - 48  2004年01月  [査読有り]

  • 中高齢者における身体活動量と中心動脈伸展性の関連 : 身体活動量の多い対象者を含めた検討 : SATプロジェクト131(呼吸・循環)

    田辺, 匠, 前田, 清司, 菅原, 順, 大槻, 毅, 久野, 譜也, 鯵坂, 隆一, 白石, 葉子, 富田, 寿人, 河合, 学, 松田, 光生

    体力科學   52 ( 6 ) 869  2003年12月

  • 動脈系コンプライアンスの加齢変化と運動中の左室後負荷 : SAT project 113(呼吸・循環)

    大槻, 毅, 菅原, 順, 気仙, 有実子, 田辺, 匠, 前田, 清司, 久野, 譜也, 鯵坂, 隆一, 松田, 光生

    体力科學   52 ( 6 ) 868  2003年12月

  • 1B12 The effect of habitual physical activity on age-related changes in central arterial properties

    SUGAWARA, Jun, TANABE, Takumi, OTSUKI, Takeshi, MAEDA, Seiji, KUNO, Shinya, AJISAKA, Ryuichi, MATSUDA, Mituso

    Advances in exercise and sports physiology   9 ( 4 ) 145  2003年12月

  • 1B11 Relationship between systemic arterial compliance and cardiorespiratory fitness : comparison study in elderly and young people(SAT project 104)

    OTSUKI, Takeshi, SUGAWARA, Jun, KESEN, Yumiko, TANABE, Takumi, MAEDA, Seiji, KUNO, Shinya, AJISAKA, Ryuichi, MATSUDA, Mitsuo

    Advances in exercise and sports physiology   9 ( 4 ) 144  2003年12月

  • 1B09 Effect of daily physical activity volume and intensity on central arterial compliance in middle and elderly persons : SAT project 106

    TANABE, Takumi, MAEDA, Seiji, SUGAWARA, Jun, OTSUKI, Takeshi, KUNO, Shinya, AJISAKA, Ryuichi, MATSUDA, Mitsuo

    Advances in exercise and sports physiology   9 ( 4 ) 143  2003年12月

  • 347. 運動は腎レニン・アンジオテンシン系を亢進させる(呼吸・循環)

    前田, 清司, 宮内, 卓, 家光, 素行, 田辺, 匠, 松田, 光生

    体力科學   52 ( 6 ) 888  2003年12月

  • 325. 老齢期からの運動トレーニングによる心臓のミトコンドリアのエネルギー供給能改善に遺伝子レベルの調節が関与する(呼吸・循環)

    家光, 素行, 宮内, 卓, 前田, 清司, 田辺, 匠, 山口, 巌, 松田, 光生

    体力科學   52 ( 6 ) 877  2003年12月

  • 086 E30101 中高年者における運動の習慣化を促進する個人内要因 : SAT プロジェクト 99

    横山, 典子, 西嶋, 尚彦, 前田, 清司, 久野, 譜也, 鯵坂, 隆一, 松田, 光生

    日本体育学会大会号   0 ( 54 ) 465  2003年08月

  • 046 F40205 レジスタンストレーニングが中高齢者の中心動脈形態・機能に及ぼす影響 : SAT プロジェクト 101

    菅原, 順, 大槻, 毅, 田辺, 匠, 前田, 清司, 久野, 譜也, 鯵坂, 隆一, 松田, 光生

    日本体育学会大会号   0 ( 54 ) 317  2003年08月

  • 046 F40204 中高齢者における運動中の心筋酸素消費量と動脈系コンプライアンスとの関連 : SAT プロジェクト 100

    大槻, 毅, 気仙, 有実子, 横山, 典子, 田辺, 匠, 菅原, 順, 前田, 清司, 久野, 譜也, 鰺坂, 隆一, 松田, 光生

    日本体育学会大会号   0 ( 54 ) 316  2003年08月

  • 中高年者における運動教室への参加が運動習慣化個人的要因に及ぼす影響 : 個別実施運動プログラムと集団実施運動プログラムの比較

    横山, 典子, 西嶋, 尚彦, 前田, 清司, 久野, 譜也, 鯵坂, 隆一, 松田, 光生

    体力科學   52 ( 0 ) 249 - 257  2003年08月  [査読有り]

     概要を見る

    The purpose of this research was to study the effects of exercise program participation on the personal factors of exercise adherence promotion in the middle-aged and elderly by comparing a group and individual exercise program. The personal factors for promoting exercise adherence, the four domains (i.e. initiative attitude, achievement satisfaction, self-recognition, and intrinsic motivation), were hypothesized. Two groups of middle-aged and elderly subjects, who volunteered to participate in different 6-month exercise programs, were examined. Group 1, 33 subjects (aged 67.7±4.3 years : mean±SD), participated in a program consisting of an individual exercise program (combination of endurance and resistance exercise, e.g. cycling exercise, dumbbell and machine exercise, once a week) and group exercise program (e.g. dance and ball game, once a week). Group 2, 27 subjects (aged 65.2±4.0 years), participated in the same individual exercise program twice a week. After the 6-month exercise program, significant improvements in group 1 were found in the self-assessment of activity score of the initiative attitude domain, the achievement satisfaction score including enjoyment, achievem

  • 高齢者における日常の身体活動量が収縮期血圧に及ぼす影響 : 動脈系コンプライアンスとの関連

    田辺, 匠, 前田, 清司, 菅原, 順, 大槻, 毅, 宮内, 卓, 久野, 譜也, 鰺坂, 隆一, 松田, 光生

    体力科學   52 ( 0 ) 167 - 176  2003年08月  [査読有り]

     概要を見る

    Arterial compliance progressively decreases with aging. This aging-induced reduction of arterial compliance causes an increase of systolic blood pressure (SBP), whereas regular exercise increases arterial compliance. We hypothesized that an increase in daily physical activity (DPA) produces a beneficial effect on systemic arterial compliance (SAC : an index of central arterial compliance) and this phenomenon could decrease SBP in the elderly. We investigated the relationship among DPA, SAC, SBP, diastolic blood pressure (DBP), and some other risk factors for cardiovascular and/or cerebrovascular events (total cholesterol, HDL-cholesterol, and HOMA-R) cross-sectionally in 127 elderly persons (42 male, 85 female : aged 71±4 years). The DPA was estimated by expended calories using an accelerometer. The SAC was calculated from a finger pulse pressure wave form recorded by using PORTAPRES ; and stroke volume obtained from the same pressure wave form based on the volume-clump method. The analyses demonstrated that SBP was directly and decreasingly affected by SAC, and that DPA had an increasing effect on SAC. Furthermore, SBP was directly and increasingly affected by DBP, and DBP was di

  • 046 F40203 運動トレーニングと大動脈における遺伝子プロファイリング

    前田, 清司, 家光, 素行, 宮内, 卓, 田辺, 匠, 松田, 光生

    日本体育学会大会号   0 ( 54 ) 315  2003年08月

  • 046 F40201 スポーツ心臓の遺伝子プロファイリング

    家光, 素行, 前田, 清司, 宮内, 卓, 田辺, 匠, 松田, 光生

    日本体育学会大会号   0 ( 54 ) 313  2003年08月

  • Aerobic exercise training reduces plasma endothelin-1 concentration in older women

    S Maeda, T Tanabe, T Miyauchi, T Otsuki, J Sugawara, M Iemitsu, S Kuno, R Ajisaka, Yamaguchi, I, M Matsuda

    JOURNAL OF APPLIED PHYSIOLOGY   95 ( 1 ) 336 - 341  2003年07月  [査読有り]

     概要を見る

    Endothelial function deteriorates with aging. On the other hand, exercise training improves the function of vascular endothelial cells. Endothelin-1 (ET-1), which is produced by vascular endothelial cells, has potent constrictor and proliferative activity in vascular smooth muscle cells and, therefore, has been implicated in regulation of vascular tonus and progression of atherosclerosis. We previously reported significantly higher plasma ET-1 concentration in middle-aged than in young humans, and recently we showed that plasma ET-1 concentration was significantly decreased by aerobic exercise training in healthy young humans. We hypothesized that plasma ET-1 concentration increases with age, even in healthy adults, and that lifestyle modification ( i.e., exercise) can reduce plasma ET-1 concentration in previously sedentary older adults. We measured plasma ET-1 concentration in healthy young women ( 21 - 28 yr old), healthy middle-aged women ( 31 - 47 yr old), and healthy older women ( 61 - 69 yr old). The plasma level of ET-1 significantly increased with aging (1.02 +/- 0.08, 1.33 +/- 0.11, and 2.90 +/- 0.20 pg/ml in young, middle-aged, and older women, respectively). Thus plasma ET-1 concentration was markedly higher in healthy older women than in healthy young or middle-aged women ( by similar to3- and 2-fold, respectively). In healthy older women, we also measured plasma ET-1 concentration after 3 mo of aerobic exercise ( cycling on a leg ergometer at 80% of ventilatory threshold for 30 min, 5 days/wk). Regular exercise significantly decreased plasma ET-1 concentration in the healthy older women (2.22 +/- 0.16 pg/ml, P &lt; 0.01) and also significantly reduced their blood pressure. The present study suggests that regular aerobic-endurance exercise reduces plasma ET-1 concentration in older humans, and this reduction in plasma ET-1 concentration may have beneficial effects on the cardiovascular system (i.e., prevention of progression of hypertension and/or atherosclerosis by endogenous ET-1).

    DOI

  • Increased plasma level of endothelin-1 following percutaneous balloon dilatation of aortic coarctation in children

    H Horigome, T Miyauchi, M Takahashi-Igari, S Maeda, A Matsui

    EUROPEAN JOURNAL OF PEDIATRICS   162 ( 7-8 ) 543 - 544  2003年07月  [査読有り]

    DOI

  • The effects of low-intensity single-leg exercise on regional arterial stiffness

    J Sugawara, T Otsuki, T Tanabe, S Maeda, S Kuno, R Ajisaka, M Matsuda

    JAPANESE JOURNAL OF PHYSIOLOGY   53 ( 3 ) 239 - 241  2003年06月

     概要を見る

    We examined the effect of low-intensity single-leg exercise (20 or 30 watt, 5 min) on pulse wave velocity from the femoral to the ankle arteries in 18 young men. After the exercise, the velocity significantly decreased in the exercised leg, but not in the counterpart, suggesting that the decrease in arterial stiffness in the exercised leg was induced mainly by exercise-related regional factors. [The Japanese Journal of Physiology 53: 239-241, 2003].

  • Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism.

    Iemitsu, M, Miyauchi, T, Maeda, S, Sakai, S, Fujii, N, Miyazaki, H, Kakinuma, Y, Matsuda, M, Yamaguchi, I

    Hypertension Research   26 ( 10 ) 829 - 837  2003年01月  [査読有り]

     概要を見る

    Hypertension-induced pathological cardiac hypertrophy (hypertensive heart) and exercise training-induced physiological cardiac hypertrophy (athletic heart) have differences in cardiac properties. We hypothesized that gene expression of energy metabolic enzymes differs between these two types of cardiac hypertrophy. To investigate whether mRNA expression of key enzymes in the long-chain fatty acid (FA), glucose, and lactic acid metabolic pathways differs between these two types of cardiac hypertrophy, we used the hearts of spontaneously hypertensive rats (SHR; 19 weeks old) as a model of the hypertensive heart, swim-trained rats (Trained; 19 weeks old, swimming training for 15 weeks) as a model of the athletic heart, and sedentary Wistar-Kyoto rats (Control; 19 weeks old). SHR developed hypertensive cardiac hypertrophy, of which cardiac function was deteriorated, whereas Trained rats developed an athletic heart, of which cardiac function was enhanced. The mRNA expression of CD36, which involved in uptake of long-chain FA, in the heart was almost never detected in the SHR group. Furthermore, the mRNA expression of key enzymes in the long-chain FA metabolic pathway (acyl CoA synthase

  • 有酸素運動の継続は加齢による心臓・骨格筋の代謝能の低下を改善する

    家光素行, 前田清司, 宮内卓

    健康維持増進とジェロンテクノロジー     81-84  2003年01月

  • 中高齢女性の全身持久性体力に及ぼす動脈系コンプライアスの影響 ―横断的および縦断的研究―

    大槻毅, 菅原順, 田辺匠, 前田清司, 久野譜也, 鰺坂隆一, 松田光生

    日本臨床スポーツ医学会誌   11   543-551  2003年01月  [査読有り]

  • Non-invasive assessment of cardiac output during exercise in healthy young humans: comparison between Modelflow method and Doppler echocardiography method

    Jun, Sugawara, Takumi, Tanabe, Motoyuki, Miyachi, Kenta, Yamamoto, Kohki, Takahashi, Motoyuki, Iemitsu, Takeshi, Otsuki, Satoshi, Homma, Seiji, Maeda, Ryuichi, Ajisaka, Mitsuo, Matsuda

    Acta Physiologica Scandinavica   179   361-366  2003年01月  [査読有り]

  • Leg cycle training decreases upper limb arterial stiffness in elderly women

    Seiji, Maeda, Masanori, Kurauchi, Takeshi, Otsuki, Takumi, Tanabe, Jun, Sugawara, Ryuichi, Ajisaka, Mitsuo, Matsuda

    International Journal of Sport and Health Science   1   202-206  2003年01月  [査読有り]

  • Difference in hypertensive and athletic hearts in gene expression of energy metabolic enzymes

    Motoyuki, Iemitsu, Takashi, Miyauchi, Seiji, Maeda, Satoshi, Sakai, Nobuharu, Fujii, Hitoshi, Miyazaki, Yoshihiko, Kakinuma, Mitsuo, Matsuda, Iwao, Yamaguchi

    Hypertension Research   26   829-837  2003年01月  [査読有り]

  • The effects of low-intensity single-leg exercise on regional arterial stiffness

    Jun, Sugawara, Takeshi, Otsuki, Takumi, Tanabe, Seiji, Maeda, Shinya, Kuno, Ryuichi, Ajisaka, Mitsuo, Matsuda

    Japanese Journal of Physiology   53   239-241  2003年01月  [査読有り]

  • Noninvasive estimate of systemic arterial compliance by using peripheral arterial blood pressure waveform during light exercise in elderly people

    Takeshi, Otsuki, Jun, Sugawara, Takumi, Tanabe, Seiji, Maeda, Ryuichi, Ajisaka, Mitsuo, Matsuda

    International Journal of Sports and Health Science   1   142-147  2003年01月  [査読有り]

  • Statistical evaluation of endurance-training effects on systolic blood pressure in elderly people using a single-case design

    Jun,Sugawara, Takeshi,Otsuki, Takumi,Tanabe, Seiji,Maeda, Kazumi,Masuda, Shinya,Kuno, Ryuichi,Ajisaka, Mitsuo,Matsuda

    International Journal of Sport and Health Science   1   148-153  2003年01月  [査読有り]

  • Simple and noninvasive estimate of systemic arterial compliance by using peripheral arterial blood pressure waveform in elderly prople

    Takeshi, Otsuki, Jun, Sugawara, Takumi, Tanabe, Seiji, Maeda, Ryuichi, Ajisaka, Mitsuo, Matsuda

    International Journal of Sport and Health Science   1   136-141  2003年01月  [査読有り]

  • Exercise training improves aging-induced decrease in eNOS expression of the aorta

    Takumi, Tanabe, Seiji, Maeda, Takashi, Miyauchi, Motoyuki, Iemitsu, Masakatsu, Takanashi, Yoko, Irukayama-Tomobe, Tomoko, Yokota, Hajime, Ohmori, Mitsuo, Matsuda

    Acta Physiologica Scandinavica   178   3-10  2003年01月  [査読有り]

  • Exercise causes a tissue-specific change of NO production in the kidney and lung

    T Miyauchi, S Maeda, M Iemitsu, T Kobayashi, Y Kumagai, Yamaguchi, I, M Matsuda

    JOURNAL OF APPLIED PHYSIOLOGY   94 ( 1 ) 60 - 68  2003年01月  [査読有り]

     概要を見る

    Nitric oxide (NO) is produced in the vascular endothelium. and is a potent vasodilator substance that participates in the regulation of local vascular tone. Exercise causes peculiar changes in systemic and regional blood flow, i.e., an increase of systemic blood flow and a redistribution of local tissue blood flow, by which the blood flow is greatly increased in the working muscles, whereas it is decreased in some organs such as the kidney and intestine. Thus we hypothesized that exercise causes a tissue-specific change of NO production in some internal organs. We studied whether exercise affects expression of NO synthase (NOS) mRNA and protein, NOS activity, and tissue level of nitrite/nitrate (stable end products of NO) in the kidneys (in which blood flow during exercise is decreased) and lungs (in which blood flow during exercise is increased with the increase of cardiac output) of rat. Rats ran on a treadmill for 45 min at a speed of 25 m/min. Immediately after this exercise, kidneys and lungs were quickly removed. Control rats remained at rest during this 45-min period. Expression of endothelial NOS (eNOS) mRNA in the kidneys was markedly lower in exercise rats than in control rats, whereas that in the lungs was significantly higher in exercise rats than in control rats. Western blot analysis confirmed down- and upregulation of eNOS protein in the kidney and lung, respectively, after exercise. On the other hand, neither expression of neuronal NOS (nNOS) mRNA and nNOS protein nor inducible NOS (iNOS) mRNA and iNOS protein in the kidneys and lungs differed between exercise and control rats. NOS activity in the kidney was significantly lower in exercise rats than in control rats, whereas that in the lung was significantly higher in exercise rats than in control rats. On the other hand, the iNOS activity in the kidneys and lungs did not differ between exercise rats and control rats. Tissue nitrite/nitrate level in the kidneys was markedly lower in exercise rats, whereas that in the lungs was significantly higher in exercise rats. The present results show that production of NO is markedly and tissue-specifically changed in the kidney and lung by exercise.

    DOI

  • 中高齢者における身体活動量が動脈系コンプライアンスに及ぼす影響 : SATプロジェクト88(呼吸・循環)

    田辺, 匠, 前田, 清司, 菅原, 順, 大槻, 毅, 柿山, 哲治, 横山, 典子, 宮内, 卓, 久野, 譜也, 鰺坂, 隆一, 松田, 光生

    体力科學   51 ( 6 ) 601  2002年12月

  • 高齢者の運動トレーニングによる動脈の伸展性の増大に血管内皮機能の改善が関与する : SATプロジェクト82(呼吸・循環)

    前田, 清司, 田辺, 匠, 大槻, 毅, 菅原, 順, 家光, 素行, 久野, 譜也, 鯵坂, 隆一, 宮内, 卓, 山口, 巌, 松田, 光生

    体力科學   51 ( 6 ) 597  2002年12月

  • 134.一過性運動は心臓の機能および形態に影響を与えるAP-1を介するシグナルを活性化させる(呼吸・循環)

    家光, 素行, 宮内, 卓, 前田, 清司, 松田, 光生, 山口, 巌

    体力科學   51 ( 6 ) 609  2002年12月

  • 102 共 C40102 中高年者の運動教室参加が運動継続要因と主観的幸福感に及ぼす影響 : SAT プロジェクト 72

    横山, 典子, 西嶋, 尚彦, 前田, 清司, 久野, 譜也, 鯵坂, 隆一, 松田, 光生

    日本体育学会大会号   0 ( 53 ) 554  2002年08月

  • 043 共 A10410 高齢者における一過性の低強度運動に対する動脈伸展性の反応 : SAT プロジェクト 73

    菅原, 順, 大槻, 毅, 田辺, 匠, 前田, 清司, 久野, 譜也, 鰺坂, 隆一, 松田, 光生

    日本体育学会大会号   0 ( 53 ) 331  2002年08月

  • Regular exercise attenuates age-related elevation in plasma endothelin-1 concentration in humans : SAT Project 68

    Maeda, Seiji, Miyauchi, Takashi, Iemitsu, Motoyuki, Yamaguchi, Iwao, Tanabe, Takumi, Otsuki, Takeshi, Ajisaka, Ryuichi, Matsuda, Mitsuo, Sugawara, Jun, Kuno, Shinya

    Circulation journal : official journal of the Japanese Circulation Society   66 ( 0 ) 511  2002年03月

  • 運動教室への参加が中高年者の主観的幸福感に及ぼす影響

    横山典子, 西嶋尚彦, 前田清司, 久野譜也, 鯵坂隆一, 松田光生

    体育測定評価研究   2   11-19  2002年01月  [査読有り]

  • 低強度運動の継続が中高齢者の大動脈伸展性に及ぼす影響

    柿山哲治, 横山典子, 前田清司, 久野譜也, 松田光生

    健康医科学   17   16-28  2002年01月

  • Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart

    Motoyuki, Iemitsu, Takashi, Miyauchi, Seiji, Maeda, Takumi, Tanabe, Yoko, Irukayama-Tomobe, Katsutoshi, Goto, Mitsuo, Matsuda, Iwao, Yamaguchi

    Clinical Science   103   152-157  2002年01月  [査読有り]

  • Aging-induced decrease in the PPAR-α level in the heart is improved by exercise training

    Motoyuki, Iemitsu, Takashi, Miyauchi, Seiji, Maeda, Takumi, Tanabe, Masakatsu, Takanashi, Yoko, Irukayama-Tomobe, Satoshi, Sakai, Hajime, Ohmori, Mitsuo, Matsuda, Iwao, Yamaguchi

    American Journal of Physiology: Heart and Circulatory Physiology   283   H1750-H1760  2002年01月  [査読有り]

  • Involvement of endogenous endothelin-1 in exercise-induced redistribution of tissue blood flow: an endothlin receptor antagonist reduces the redistribution

    Seiji, Maeda, Takashi, Miyauchi, Motoyuki, Iemitsu, Takumi, Tanabe, Yoko, Irukayama-Tomobe, Katsutoshi, Goto, Iwao, Yamaguchi, Mitsuo, Matsuda

    Circulation   106   2188-2193  2002年01月  [査読有り]

  • Effects of exercise training on expression of endothelin-1 mRNA in the aorta of aged rats

    Seiji, Maeda, Takashi, Miyauchi, Motoyuki, Iemitsu, Takumi, Tanabe, Tomoko, Yokota, Katsutoshi, Goto, Iwao, Yamaguchi, Mitsuo, Matsuda

    Clinical Science   103   118-123  2002年01月  [査読有り]

  • 運動と血管内皮由来血管作動性物質による循環調節

    松田光生, 前田清司, 宮内卓

    平成11~13年度文部省科学研究費基盤研究B報告書     1-74  2002年01月

  • 一過性の低強度自転車運動が運動脚と非運動脚の動脈伸展性に及ぼす影響(【呼吸・循環】)

    菅原, 順, 大槻, 毅, 田辺, 匠, 前田, 清司, 久野, 譜也, 鰺坂, 隆一, 松田, 光生

    体力科學   50 ( 6 ) 812  2001年12月

  • 持久的トレーニングにより安静時及び運動時の動脈系コンプライアンスは増大する : SATプロジェクト63(【呼吸・循環】)

    田辺, 匠, 前田, 清司, 菅原, 順, 大槻, 毅, 久野, 譜也, 宮内, 卓, 鰺坂, 隆一, 松田, 光生

    体力科學   50 ( 6 ) 800  2001年12月

  • 148.老齢期からの運動トレーニングによる心臓の脂質代謝能力の改善に遺伝子レベルの調節が関与する(【呼吸・循環】)

    家光, 素行, 宮内, 卓, 前田, 清司, 田辺, 匠, 大森, 肇, 松田, 光生

    体力科學   50 ( 6 ) 806  2001年12月

  • 165.腎臓における運動時のエンドセリンの産生増大は一酸化窒素の産生を抑制する(【呼吸・循環】)

    前田, 清司, 宮内, 卓, 家光, 素行, 田辺, 匠, 松田, 光生

    体力科學   50 ( 6 ) 815  2001年12月

  • 047HALL06 中高齢者における動脈系コンプライアンアスと有気的持久力との関係 : SATプロジェクト38

    大槻, 毅, 菅原, 順, 田辺, 匠, 前田, 清司, 久野, 譜也, 鯵坂, 隆一, 松田, 光生

    日本体育学会大会号   0 ( 52 ) 323  2001年08月

  • 045N10005 中高齢者における身体活動量が動脈系伸展性および収縮期血圧に及ぼす影響 : SATプロジェクト39

    田辺, 匠, 前田, 清司, 菅原, 順, 大槻, 毅, 横山, 典子, 柿山, 哲治, 久野, 譜也, 宮内, 卓, 前田, 清司, 鯵坂, 隆一, 松田, 光生

    日本体育学会大会号   0 ( 52 ) 300  2001年08月

  • 045N10005 中高齢者における身体活動量が動脈系伸展性および収縮期血圧に及ぼす影響 : SATプロジェクト39

    田辺, 匠, 前田, 清司, 菅原, 順, 大槻, 毅, 横山, 典子, 柿山, 哲治, 久野, 譜也, 宮内, 卓, 前田, 清司, 鯵坂, 隆一, 松田, 光生

    日本体育学会大会号   0 ( 52 ) 300  2001年08月

  • 047HALL11 老齢期からの運動トレーニングは心機能に関与する遺伝子発現の加齢変化を改善する

    家光, 素行, 宮内, 卓, 前田, 清司, 田辺, 匠, 大森, 肇, 松田, 光生

    日本体育学会大会号   0 ( 52 ) 328  2001年08月

  • 6ヶ月間の低強度運動トレーニングが中高年女性の大動脈伸展性に及ぼす影響

    柿山,哲治, 横山,典子, 前田清司, 久野,譜也, 高石,昌弘, 松田,光生

    日本臨床スポーツ医学会誌   9 ( 2 ) 226 - 233  2001年04月  [査読有り]

  • 運動時の心拍出量の非侵襲的測定 -Modelflow法とimpedance cardiography法との比較-

    菅原順, 田辺匠, 大槻毅, 前田清司, 鯵坂隆一, 松田光生

    日本臨床スポーツ医学会誌   9   360-367  2001年01月  [査読有り]

  • Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat

    Motoyuki Iemitsu, Takashi Miyauchi, Seiji Maeda, Satoshi Sakai, Tsutomu Kobayashi, Nobuharu Fujii, Hitoshi Miyazaki, Mitsuo Matsuda, Iwao Yamaguchi

    American Journal of Physiology - Regulatory Integrative and Comparative Physiology   281 ( 6 ) R2029 - R2036  2001年  [査読有り]

     概要を見る

    Pressure overload, such as hypertension, to the heart causes pathological cardiac hypertrophy, whereas chronic exercise causes physiological cardiac hypertrophy, which is defined as athletic heart. There are differences in cardiac properties between these two types of hypertrophy. We investigated whether mRNA expression of various cardiovascular regulating factors differs in rat hearts that are physiologically and pathologically hypertrophied, because we hypothesized that these two types of cardiac hypertrophy induce different molecular phenotypes. We used the spontaneously hypertensive rat (SHR group
    19 wk old) as a model of pathological hypertrophy and swim-trained rats (trained group
    19 wk old, swim training for 15 wk) as a model of physiological hypertrophy. We also used sedentary Wistar-Kyoto rats as the control group (19 wk old). Left ventricular mass index for body weight was significantly higher in SHR and trained groups than in the control group. Expression of brain natriuretic peptide, angiotensin-converting enzyme, and endothelin-1 mRNA in the heart was significantly higher in the SHR group than in control and trained groups. Expression of adrenomedullin mRNA in the heart was significantly lower in the trained group than in control and SHR groups. Expression of β1-adrenergic receptor mRNA in the heart was significantly higher in SHR and trained groups than in the control group. Expression of β1-adrenergic receptor kinase mRNA, which inhibits β1-adrenergic receptor activity, in the heart was markedly higher in the SHR group than in control and trained groups. We demonstrated for the first time that the manner of mRNA expression of various cardiovascular regulating factors in the heart differs between physiological and pathological cardiac hypertrophy.

    PubMed

  • Endothelin-1 production is enhanced by rotenone, a mitochondrial complex 1 inhibitor, in cultured rat cardiomyocytes

    Ko-ichi, Yuhki, Takashi, Miyauchi, Yoshihiko, Kakinuma, Nobuyuki, Murakoshi, Seiji, Maeda, Katsutoshi, Goto, Iwao, Yamaguchi, Takahiko, Suzuki

    Journal of Cardiovascular Pharmacology   38   850-858  2001年01月  [査読有り]

  • Change in post-exercise vagal reactivation with exercise training and detraining in young men

    J. Sugawara, H. Murakami, S. Maeda, S. Kuno, M. Matsuda

    European Journal of Applied Physiology   85 ( 3-4 ) 259 - 263  2001年  [査読有り]

     概要を見る

    We studied the effects of aerobic exercise training and detraining in humans on post-exercise vagal reactivation. Ten healthy untrained men trained for 8 weeks using a cycle ergometer [70% of initial maximal oxygen uptake (VO2max) for 1 h, 3-4 days·week-1] and then did not exercise for the next 4 weeks. Post-exercise vagal reactivation was evaluated as the time constant of the beat-by-beat decrease in heart rate during the 30 s (t30) immediately following 4 min exercise at 80% of ventilatory threshold (VT). The VO2max and the oxygen uptake at VT had significantly increased after the 8 weeks training programme (P&lt
    0.0001, P&lt
    0.001, respectively). The t30 had shortened after training, and values after 4 weeks and 8 weeks of training were significantly shorter than the initial t30 (P&lt
    0.05, P&lt
    0.01, respectively). The change in the t30 after 8 weeks of training closely and inversely correlated with the initial t30 (r=-0.965, P&lt
    0.0001). The reduced t30 was prolonged significantly after 2 weeks of detraining, and had returned almost to the baseline level after a further 2 weeks of detraining. These results suggest that aerobic exercise training of moderate intensity accelerates post-exercise vagal reactivation, but that the accelerated function regresses within a few weeks of detraining.

    DOI PubMed

  • Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans

    Seiji, Maeda, Takashi, Miyauchi, Tetsuji, Kakiyama, Jun, Sugawara, Motoyuki, Iemitsu, Yoko, Irukayama-Tomobe, Haruka, Murakami, Yoshito, Kumagai, Shinya, Kuno, Mitsuo, Matsuda

    Life Sciences   69 ( 9 ) 1005 - 1016  2001年01月  [査読有り]

     概要を見る

    Vascular endothelial cells produce nitric oxide (NO), which is a potent vasodilator substance and has been proposed as having antiatherosclerotic property. Vascular endothelial cells also produce endothelin-1 (ET-1), which is a potent vasoconstrictor peptide and has potent proliferating activity on vascular smooth muscle cells. Therefore, ET-1 has been implicated in the progression of atheromatous vascular disease. Because exercise training has been reported to produce an alteration in the function of vascular endothelial cells in animals, we hypothesized that exercise training influences the production of NO and ET-1 in humans. The purpose of the present study was to examine whether chronic exercise could influence the plasma levels of NO (measured as the stable end product of NO, i.e., nitrite/nitrate [NOx]) and ET-1 in humans. Eight healthy young subjects (20.3 +/- 0.5 yr old) participated in the study and exercised by cycling on a leg ergometer (70% VO2max for 1 hour, 3-4 days/week) for 8 weeks. Venous plasma concentrations of NOx and ET-1 were measured before and after (immediately before the end of 8-week exercise training) the exercise training, and also after the 4th and 8t

  • 運動時の血流調節における内皮由来血管作動性物質の関与

    前田清司

    平成12年度文部省科学研究費基盤研究C (企画調査) 報告書「運動時の循環調節メカニズム」の共同研究に関する企画調査     5-7  2001年01月

  • 低強度運動が動脈系コンプライアンスに及ぼす影響

    菅原順, 大槻毅, 田辺匠, 前田清司, 鯵坂隆一, 松田光生

    Arterial Stiffness   1   40  2001年01月

  • 中高年女性における下肢抵抗性運動による運動筋酸素化動態 : SATプロジェクト5

    鈴木, 康文, 鰺坂, 隆一, 久野, 譜也, 宮永, 豊, 松田, 光生, 田辺, 匠, 村上, 晴香, 前田, 清司, 渡辺, 重行, 菅原, 順

    体力科學   49 ( 6 ) 884  2000年12月

  • 運動により動脈伸展性は増大する : SATプロジェクト25

    田辺, 匠, 前田, 清司, 菅原, 順, 宮内, 卓, 久野, 譜也, 鰺坂, 隆一, 松田, 光生

    体力科學   49 ( 6 ) 718  2000年12月

  • 101.慢性運動は加齢による心臓エネルギー代謝機能の低下を改善する

    家光, 素行, 宮内, 卓, 前田, 清司, 田辺, 匠, 入鹿山, 容子, 大森, 肇, 松田, 光生, 山口, 巌

    体力科學   49 ( 6 ) 717  2000年12月

  • 82.血管収縮物質であるエンドセリン-1は運動時の血流再配分に関与する

    前田, 清司, 宮内, 卓, 入鹿山, 容子, 家光, 素行, 田辺, 匠, 山口, 巖, 松田, 光生

    体力科學   49 ( 6 ) 707  2000年12月

  • 0050 健常者における慢性(8週間)の運動トレーニングによる血中NOx濃度と血中エンドセリン-1濃度の変化

    前田, 清司, 菅原, 順, 入鹿山, 容子, 村上, 晴香, 久野, 譜也, 松田, 光生, 宮内, 卓, 家光, 素行, 山口, 巌, 熊谷, 嘉人, 柿山, 哲治

    Japanese circulation journal   64 ( 0 ) 197  2000年03月  [査読有り]

  • P698 圧負荷肥大心(病的肥大心)とスポーツ肥大心(生理的肥大心)における種々の心血管調節性因子の遺伝子発現様式は異なる

    家光, 素行, 宮内, 卓, 前田, 清司, 酒井, 俊, 小林, 勉, 山口, 巌, 藤井, 宣晴, 宮崎, 均

    Japanese circulation journal   64 ( 0 ) 634  2000年03月

  • P439 病的肥大心とスポーツ肥大心 (生理的肥大心) におけるエネルギー供給機構の主要な各種酵素の遺伝子発現様式の差違

    家光, 素行, 宮内, 卓, 前田, 清司, 柿沼, 由彦, 小林, 勉, 山口, 巖, 藤井, 宣晴, 宮崎, 均

    Japanese circulation journal   64 ( 0 ) 569  2000年03月

  • 若齢男性における持久性トレーニングおよび脱トレーグが安静時心臓自律神経系活動に及ぼす影響

    菅原, 順, 村上, 晴香, 久野, 譜也, 前田, 清司, 柿山, 哲治, 松田, 光生

    体力科学   49 ( 1 ) 121 - 127  2000年02月

  • 若齢男性における持久性トレーニングおよび脱トレーニングが安静時心臓自律神経系活動に及ぼす影響

    菅原順, 村上晴香, 久野譜也, 前田清司, 柿山哲治, 松田光生

    体力科学   49   121-128  2000年01月  [査読有り]

  • 中高齢女性における運動終了後の心臓副交感神経活動回復応答に及ぼすトレーニングの効果

    菅原順, 相馬りか, 久野譜也, 前田清司, 坂戸英樹, 石津政雄, 鯵坂隆一, 松田光生

    日本臨床スポーツ医学会誌   8   71-75  2000年01月  [査読有り]

  • 中高年者における運動習慣の確立および運動の継続がQOLにおよぼす影響

    横山典子, 西嶋尚彦, 岡田あき子, 大迫剛, 前田清司, 久野譜也, 石津政雄, 鯵坂隆一, 松田光生

    高齢者の生活機能増進法 -地域システムと具体的ガイドライン-     355-357  2000年01月  [査読有り]

  • 下肢抵抗性運動における心血管応答 -安全でより効果的な筋力増強訓練の検討-

    鈴木康文, 鰺坂隆一, 久野譜也, 宮永豊, 松田光生, 増田和実, 田辺匠, 村上晴香, 前田清司, 渡辺重行, 菅原順

    高齢者の生活機能増進法 -地域システムと具体的ガイドライン-     343-345  2000年01月  [査読有り]

  • 女性中高年者における低強度運動の継続が大動脈伸展性におよぼす影響

    柿山哲治, 横山典子, 前田清司, 久野譜也, 高石昌弘, 松田光生

    高齢者の生活機能増進法 -地域システムと具体的ガイドライン-     340-342  2000年01月  [査読有り]

  • 中高齢女性における運動終了後の心臓副交感神経系活動回復応答におよぼす運動トレーニングの効果

    菅原順, 相馬りか, 久野譜也, 前田清司, 石津政雄, 鯵坂隆一, 松田光生

    高齢者の生活機能増進法 -地域システムと具体的ガイドライン-     337-339  2000年01月  [査読有り]

  • 運動中の血管コンプライアンスの変化

    田辺匠, 前田清司, 菅原順, 大槻毅, 宮内卓, 久野譜也, 鯵坂隆一, 松田光生

    高齢者の生活機能増進法 -地域システムと具体的ガイドライン-     334-336  2000年01月  [査読有り]

  • Intense exercise causes decrease in expression of both endothelial NO synthase and tissue NOx level in hearts

    Motoyuki Iemitsu, Takashi Miyauchi, Seiji Maeda, Koichi Yuki, Tsutomu Kobayashi, Yoshito Kumagai, Nobuhiro Shimojo, Iwao Yamaguchi, Mitsuo Matsuda

    American Journal of Physiology - Regulatory Integrative and Comparative Physiology   279 ( 3 ) R951 - R959  2000年  [査読有り]

     概要を見る

    Cardiac myocytes produce nitric oxide (NO). We studied the effects of intense exercise on the expression of NO synthase (NOS) and the tissue level of nitrite (NO2/-)/nitrate (NO3/-) (i.e., NOx), which are stable end products of NO in the heart. Rats ran on a treadmill for 45 min. Immediately after this exercise, the heart was quickly removed. Control rats remained at rest during the same 45-min period. The mRNA level of endothelial NOS (eNOS) in the heart was markedly lower in the exercised rats than in the control rats. Western blot analysis confirmed downregulation of eNOS protein in the heart after exercise. Tissue NOx level in the heart was significantly lower in the exercised rats than in the control rats. The present study revealed for the first time that production of NO in the heart is decreased by intense exercise. Because NO attenuates positive inotropic and chronotropic responses to β1-adrenergic stimulation in the heart, the decrease in cardiac production of NO by intense exercise may contribute to the acceleration of increase in myocardial contractility and heart rate during intense exercise.

    PubMed

  • 運動生理学会・バイオメカニクス学会合同大会傍聴記:第8回日本運動生理学会

    前田清司

    体育の科学   50   833-836  2000年01月

  • 335.運動時におけるNitric oxide(NO)産生の臓器特異性

    前田, 清司, 宮内, 卓, 家光, 素行, 山口, 巖, 松田, 光生

    体力科學   48 ( 6 ) 880  1999年12月

  • 331.運動時負荷による心臓での一酸化窒素(NO)産生の変化

    家光, 素行, 宮内, 卓, 前田, 清司, 山口, 巖, 松田, 光生

    体力科學   48 ( 6 ) 878  1999年12月

  • 1118 心臓で産生されるNitric Oxide(NO)は運動時の心機能調節に関与する : ラットでの検討

    家光, 素行, 宮内, 卓, 山口, 巖, 前田, 清司, 松田, 光生, 熊谷, 嘉人, 杉下, 靖郎

    Japanese circulation journal   63 ( 1 ) 430  1999年03月  [査読有り]

  • 0526 運動時の血流再配分における血管内皮由来血管作動性物質(endothelin [ET]-1, -酸化窒素[NO])の関与

    前田, 清司, 松田, 光生, 宮内, 卓, 家光, 素行, 山口, 巌, 杉下, 靖郎

    Japanese circulation journal   63 ( 1 ) 281  1999年03月

  • (E61009) Exercise Training Causes an Alteration in Plasma NOx Level in Healthy Young Humans

    MAEDA,Seiji, MIYAUCHI,Takashi, KAKIYAMA,Tetsuji, SUGAWARA,Jun, IEMITSU,Motoyuki, IRUKAYAMA-TOMOBE,Yoko, MURAKAMI,Haruka, KUMAGAI,Yoshito, KUNO,Shinya, MATSUDA,Mitsuo

    Advances in exercise and sports physiology   5 ( 4 ) 177  1999年01月  [査読有り]

  • 大動脈伸展性の加齢変化と運動トレーニング応答の個体差

    柿山哲治, 横山典子, 前田清司, 松田光生, 高石昌弘

    小野スポーツ科学   7   35-44  1999年01月

  • Pathophysiological roles of endothelin-1 in Dahl salt-sensitive hypertension

    Takanori Ikeda, Hisashi Ohta, Megumu Okada, Nobuko Kawai, Rumi Nakao, Peter K.S. Siegl, Tsutomu Kobayashi, Seiji Maeda, Takashi Miyauchi, Masaru Nishikibe

    Hypertension   34 ( 3 ) 514 - 519  1999年  [査読有り]

     概要を見る

    The purpose of the present experiment was to study the pathophysiological roles of endothelin-1 (ET-1) in salt-sensitive hypertension with the use of Dahl salt-sensitive (DS) and salt-resistant (DR) rats. PreproET-1 mRNA expression was determined by reverse transcription- polymerase chain reaction. In the kidney, expression of preproET-1 mRNA was greater in DS rats on a normal salt diet compared with DR rats of the same age. In DS rats, the level of preproET-1 mRNA expression in kidney had a significant correlation with systolic blood pressure. The expression of preproET-1 mRNA in aorta and kidney was increased by 3-week high salt intake in DS rats but not in DR rats. Expression of preproET-1 mRNA and ET-1 levels in left ventricle was exaggerated by high salt intake in DS rats. However, there was no significant difference in plasma ET-1 levels between DS and DR rats regardless of salt intake. Pressor response curves for ET-1 in DS rats with or without high salt intake were significantly shifted to the left compared with those in DR rats. A single oral dose (3 to 10 mg/kg) of J- 104132 (L-753 037), a potent, orally active mixed endothelin A and B (ET(A)/ET(B)) receptor antagonist, reduced blood pressure to normotensive levels in DS rats with high salt intake, and its action was maintained for ≥24 hours. In DS rats with normal salt intake, J-104132 (10 mg/kg) slightly but significantly decreased blood pressure. DR rats did not show obvious depressor responses to J-104132 (10 mg/kg) regardless of salt intake. These results suggest that ET-1 acts as one of the pathophysiological factors in the development and maintenance of salt-sensitive hypertension, and a mixed ET(A)/ET(B) receptor antagonist could be useful in the treatment for salt- sensitive hypertension.

    DOI PubMed

  • Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo

    Yoshihiko, Kakinuma, Takashi, Miyauchi, Tsutomu, Kobayashi, Koichi, Yuki, Seiji, Maeda, Satoshi, Sakai, Katsutoshi, Goto, Iwao, Yamaguchi

    Life Sciences   65   1671-1683  1999年01月  [査読有り]

  • Prolonged exercise causes an increase in endothelin-1 production in the heart in rats

    S Maeda, T Miyauchi, S Sakai, T Kobayashi, M Iemitsu, K Goto, Y Sugishita, M Matsuda

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   275 ( 6 ) H2105 - H2112  1998年12月  [査読有り]

     概要を見る

    Cardiac myocytes produce endothelin-1 (ET-1). ET-1 has potent positive inotropic and chronotropic effects. We investigated whether production of ET-1 in the heart is altered by prolonged exercise in rats. Rats ran on a treadmill for 45 min. Immediately after this exercise the heart and lungs were quickly removed. Control rats remained at rest during this 45-min period. Expression of preproET-1 mRNA in the heart was markedly higher in the exercised than in the control rats. The peptide level of ET-1 in the heart was also markedly higher in the exercised rats. Expression of endothelin type A- and type B-receptor mRNA and endothelin-converting enzyme mRNA in the heart did not differ between the groups. The peptide level of ET-1 and the preproET-1 mRNA level in the lungs of the exercised rats did not differ from those in the control rats. The present results show that production of ET-1 is markedly increased tissue specifically in the heart by exercise without appreciable changes in endothelin-converting enzyme and endothelin receptor expression. The present study suggests that myocardial ET-1 may participate in modulation of cardiac function during exercise.

  • 185.スポーツ合宿における血漿たんぱく性Sulfhydryl Groupの変動:大学陸上長距離チームにおける検討

    齋藤 実, 鍋倉 賢治, 白井 克佳, 菅原 順, 小澤 聡, 前田 清司, 稲山 貴代, 永井 純, 松田 光生

    体力科學   47 ( 6 ) 795 - 795  1998年12月

    CiNii

  • 運動時の循環調節におけるエンドセリンの役割

    前田, 清司, 宮内, 卓, 松田, 光生

    日本体育学会大会号   0 ( 49 ) 96  1998年08月

  • 20. 運動による endothelin-1の産生 : 心臓における検討

    前田, 清司, 宮内, 卓, 酒井, 俊, 小林, 勉, 松田, 光生

    日本運動生理学雑誌   5 ( 1 ) 46  1998年03月

  • 6ヶ月間の運動プログラム参加後における自己効力感の変化

    藤森久美子, 今井多賀子, 牛島直美, 前田清司, 松田光生

    いばらき健康・スポーツ科学   16   53-57  1998年01月  [査読有り]

  • Prolonged exercise causes an increase in endothelin-1 production in the heart in rats

    Seiji, Maeda, Takashi, Miyauchi, Satoshi, Sakai, Tsutomu, Kobayashi, Motoyuki, Iemitsu, Katsutoshi, Goto, Yasuro, Sugishita, Mitsuo, Matsuda

    American Journal of Physiology: Heart and Circulatory Physiology   275 ( 6 Pt 2 ) H2105 - H2112  1998年01月  [査読有り]

     概要を見る

    Cardiac myocytes produce endothelin-1 (ET-1). ET-1 has potent positive inotropic and chronotropic effects. We investigated whether production of ET-1 in the heart is altered by prolonged exercise in rats. Rats ran on a treadmill for 45 min. Immediately after this exercise the heart and lungs were quickly removed. Control rats remained at rest during this 45-min period. Expression of preproET-1 mRNA in the heart was markedly higher in the exercised than in the control rats. The peptide level of ET-1 in the heart was also markedly higher in the exercised rats. Expression of endothelin type A- and type B-receptor mRNA and endothelin-converting enzyme mRNA in the heart did not differ between the groups. The peptide level of ET-1 and the preproET-1 mRNA level in the lungs of the exercised rats did not differ from those in the control rats. The present results show that production of ET-1 is markedly increased tissue specifically in the heart by exercise without appreciable changes in endothelin-converting enzyme and endothelin receptor expression. The present study suggests that myocardial ET-1 may participate in modulation of cardiac function during exercise.

  • Endothelin-1 expression in hearts of transgenic hypertensive mice overexpressing angiotensin II

    S Maki, T Miyauchi, S Sakai, T Kobayashi, S Maeda, Y Takata, F Sugiyama, A Fukamizu, K Murakami, K Goto, Y Sugishita

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   31   S412 - S416  1998年  [査読有り]

     概要を見る

    Cardiac myocytes and vascular endothelial cells produce endothelin (ET)-1, which has potent hypertrophic effects on cardiac myocytes. Although in cultured cardiomyocytes, angiotensin 11 (Ang II) was reported to enhance ET-1 production in vitro, it is not known whether ET-1 production is enhanced by Ang 11 in vivo. We investigated the production and pathophysiologic roles of ET-1 in 20-week-old male transgenic hypertensive mice (THM), in which the renin-angiotensin system (RAS) was markedly activated because of the presence of both human renin and angiotensinogen genes. Systolic blood pressure and the ratio of left ventricular weight to body weight were significantly higher in the THM than in control mice, indicating that THM developed cardiac hypertrophy. ET-1 production was significantly increased in the heart of because both ET-1 mRNA expression and peptide levels were significantly higher than in controls. However, circulating plasma ET-1 levels did not differ between the groups, and blood pressure did not change after i.v. injection with a high dose (3 mg/kg) of the ETA/B-nonselective receptor antagonist SB209670. These findings suggest that increased cardiac ET-1 production may contribute to the progression of cardiac hypertrophy and that endogenous ET-1 may not be involved in the short-term modulation of blood pressure in THM of this age.

  • Exercise causes a tissue-specific enhancement of endothelin-1 mRNA expression in internal organs

    Seiji, Maeda, Takashi, Miyauchi, Tsutomu, Kobayashi, Katsutoshi, Goto, Mitsuo, Matsuda

    Journal of Applied Physiology   85 ( 2 ) 425 - 431  1998年01月  [査読有り]

     概要を見る

    Endothelin-1 (ET-1) is a potent vasoconstrictor peptide, which also potentiates contractions to norepinephrine in human internal mammary and coronary vessels. Exercise causes a redistribution of blood flow, i.e., the increase in working muscles that is partly attributable to a decrease in visceral blood flow. We hypothesized that exercise causes a tissue-specific increase in ET-1 expression in internal organs. We studied whether exercise affects expression of preproET-1 mRNA in the kidneys and lungs. The rats performed treadmill running (0% grade) for 45 min at a speed of 25 m/min. The plasma concentrations of ET-1, epinephrine, and norepinephrine were greater in the exercise rats than in the sedentary control rats. The expression of preproET-1 mRNA in the kidneys was markedly higher in the exercise rats than in the sedentary control rats, whereas that in the lungs did not differ between the two groups. Therefore, the present study provides a possibility that the exercise-induced increase in production of ET-1 in the kidneys causes vasoconstriction and hence decreases blood flow in the kidneys through its direct vasoconstrictive action and/or its indirect effect of enhancing vasoco

  • Endothelin-1 in the heart during exercise

    S Maeda, T Miyauchi, S Sakai, T Kobayashi, T Goto, Y Sugishita, M Matsuda

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   31   S392 - S394  1998年  [査読有り]

     概要を見る

    In addition to its potent vasocontractile effects, endothelin-1 (ET-1) has potent positive inotropic and chronotropic effects on isolated heart muscles in vitro. However, it is not known whether the production of ET-1 in the heart is altered by exercise. In this study we investigated the production of ET-1 in the heart during exercise. Rats performed treadmill running of 45-min duration. Sedentary rats served as controls. Immediately after exercise, the heart was quickly removed. The peptide level of ET-1 in the heart was measured by a sandwich-enzyme immunoassay. The peptide level of ET-1 in the heart was significantly higher in the exercise group than in the control sedentary group. Therefore, we have demonstrated that production of ET-1 in the heart is increased by exercise. The present study suggests that myocardial ET-1 participates in the modulation of cardiac function during exercise.

  • 上腕動脈血管開口伝播速度を用いた動脈硬化度の測定 : 大洋村健康づくりプロジェクト(5)

    柿山, 哲治, 前田, 清司, 横山, 典子, 和田, 光弘, 石津, 政雄, 西嶋, 尚彦, 久野, 譜也, 岡田, 守彦, 松田, 光生, 高石, 昌弘

    体力科學   46 ( 6 ) 682  1997年12月

  • 587.運動により腎におけるendothelin-1の生産が増大する

    前田, 清司, 宮内, 卓, 酒井, 俊, 杉下, 靖郎, 杉浦, 弘一, 秋本, 崇之, 龍野, 美恵子, 山本, 祐里江, 松田, 光生

    体力科學   46 ( 6 ) 906  1997年12月

  • Down-regulation of ETB receptor, but not ETA receptor, in congestive lung secondary to heart failure. Are marked increases in circulating endothelin-1 partly attributable to decreases in lung ETB receptor-mediated clearance of endothelin-1?

    T Kobayashi, T Miyauchi, S Sakai, Yamaguchi, I, K Goto, Y Sugishita

    LIFE SCIENCES   62 ( 2 ) 185 - 193  1997年12月  [査読有り]

     概要を見る

    Receptors for endothelin (ET)-1, a potent vasoconstrictor peptide, have two isoforms, i.e. ETA receptors and ETB receptors. We previously reported that an ETA receptor antagonist greatly ameliorated pulmonary hypertension due to congestive heart failure (CHF) in rats. In the present study of rats with pulmonary congestion secondary to CHF, we determined not only ETA receptor mRNA expression but also ETB receptor mRNA expression in the congestive lung because lung ETB receptors are reported to be important for the clearance of circulating ET-1. We also measured lung ET-I and circulating ET-I levels. The expression of ETB receptor mRNA in the lung was significantly lower in rats with CHF than in age-matched control rats, while the expression of ETA receptor mRNA did not differ between the two groups. The protein level of ETB receptor, determined by Western blot, in the lung was lower in the rats with CHF than in the control rats, while the protein level of ETA receptor did not differ between the two groups. The lung ET-1 level and plasma ET-1 level were significantly higher in the rats with CHF than in the controls by 1.4-fold and 5.3-fold, respectively. Thus, in the rats with CHF, ET-1 was increased to a much greater extent in plasma than in the lung. The present findings suggest that selective down-regulation of ETB receptor, but not ETA receptor, occurs in the congestive lung. Since lung ETB receptors play a role in the clearance of circulating ET-1, we propose that down-regulation of lung ETB receptors partly contributes to marked increases in circulating ET-1 and that increased ET-1 in the circulating plasma as well as in the lung is involved in the progression of pulmonary hypertension in CHF.

  • 0107 Enhanced Endothelin Pathway Is Involved in the Development of Cardiac Hypertrophy in the Mouse Transgenically Activated Renin-Angiotensin System

    Maki, Shinnichi, Miyauchi, Takashi, Sakai, Satoshi, Kobayashi, Tsutomu, Takata, Yoshiko, Maeda, Seiji, Sugiyama, Fumihiro, Fukamizu, Akiyoshi, Yamaguchi, Iwao, Murakami, Kazuo, Goto, Katsutoshi, Sugishita, Yasuro

    Japanese circulation journal   61 ( 7 ) 545 - 546  1997年06月

  • P784 運動負荷による心臓でのendothelin-1産生の増大 : 強心作用を有するendothelin-1は運動負荷時の心機能亢進に関与するか?

    前田, 清司, 松田, 光生, 宮内, 卓, 酒井, 俊, 小林, 勉, 後藤, 勝年, 杉下, 靖郎

    Japanese circulation journal   61 ( 0 ) 582  1997年03月

  • 0107 つくば高血圧マウス(ヒトレニンおよびアンジオテンシノーゲン遺伝子導入マウス)の心肥大進展における内因性エンドセリンの関与 : エンドセリン拮抗薬の心肥大改善効果

    牧, 真一, 宮内, 卓, 酒井, 俊, 小林, 勉, 高田, 佳子, 前田, 清司, 山口, 巌, 杉下, 靖郎, 杉山, 文博, 後藤, 勝年, 深水, 昭吉, 村上, 和雄

    Japanese circulation journal   61 ( 0 ) 137  1997年03月

  • 0083 運動時の血流再分布における血管収縮ペプチドendothelin-1の役割

    前田, 清司, 松田, 光生, 宮内, 卓, 酒井, 俊, 小林, 勉, 後藤, 勝年, 杉下, 靖郎

    Japanese circulation journal   61 ( 0 ) 131  1997年03月

  • 一過性運動負荷による唾液中分泌型 IgA の変動 ―視覚障害者における検討―

    秋本崇之, 香田泰子, 赤間高雄, 柳川真美, 龍野美恵子, 杉浦弘一, 柿山哲治, 前田清司, 河野一郎, 松田光生

    体力科学   46   523-528  1997年01月  [査読有り]

  • 換気性作業閾値前後の運動が血漿たんぱく性 sulfhydryl group におよぼす影響

    斉藤実, 稲山貴代, 前田清司, 松田光生

    体力科学   46   365-374  1997年01月  [査読有り]

  • Differences in the change in the time course of plasma endothelin-1 and endothelin-3 levels after exercise in humans: the response to exercise of endothelin-3 is more rapid than that of endothelin-1

    Seiji, Maeda, Takashi, Miyauchi, Katsutoshi, Goto, Mitsuo, Matsuda

    Life Sciences   61 ( 4 ) 419 - 425  1997年01月  [査読有り]

     概要を見る

    Several studies have indicated that endothelin-1 (ET-1) and endothelin-3 (ET-3) are produced by different cells. Although ET-1 is produced by vascular endothelial cells, these cells do not produce ET-3. The presence of ET-3 in the brain of several species suggests that ET-3 is a novel neuropeptide. It is unclear whether there are differences in the release of ET-1 and ET-3 under various physiological conditions in humans. In the present study, we measured the plasma concentrations of both ET-1 and ET-3 before and after endurance exercise on a cycle ergometer. Male athletes exercised on a cycle ergometer for 30 min at intensity of 130% of their individual ventilatory threshold (VT), which is intense exercise. Plasma ET-1 and ET-3 were greatly elevated by exercise, but there was a marked difference in the time-course of the change in plasma concentration between the two peptides. The level of ET-1 peaked 30 min after exercise, whereas that of ET-3 peaked immediately after exercise. Thus, plasma ET-3 increased faster than plasma ET-1 after exercise. The exercise-induced change in the time course in plasma ET-3, but not in ET-1, is similar to that in plasma norepinephrine which is a ne

  • Does endothelin-1 participate in the exercise-induced changes of blood flow distribution of muscles in humans?

    Seiji Maeda, Takashi Miyauchi, Michiko Sakane, Makoto Saito, Shinichi Maki, Katsutoshi Goto, Mitsuo Matsuda

    Journal of Applied Physiology   82 ( 4 ) 1107 - 1111  1997年  [査読有り]

     概要を見る

    Endothelin-1 (ET-1) is an endothelium-derived potent vasoconstrictor peptide that potentiates contractions to norepinephrine in human vessels. We previously reported that the circulating plasma concentration of ET-1 is significantly increased after exercise (S. Maeda, T. Miyauchi, K. Goto, and M. Matsuda. J. Appl. Physiol. 77: 1399-1402, 1994). To study the roles of ET- 1 during and after exercise, we investigated whether endurance exercise affects the production of ET-1 in the circulation of working muscles and nonworking muscles. Male athletes performed one-leg cycle ergometer exercise of 30-min duration at intensity of 110% of their individual ventilatory threshold. Plasma concentrations of ET-1 in both sides of femoral veins (veins in the working leg and nonworking leg) and in the femoral artery (artery in the nonworking leg) were measured before and after exercise. The plasma ET-1 concentration in the femoral vein in the nonworking leg was significantly increased after exercise, whereas that in femoral vein in the working leg was not changed. The arteriovenous difference in ET-1 concentration was significantly increased after exercise in the circulation of the nonworking leg but not of the working leg, which suggests that the production of ET-1 was increased in the circulation of the nonworking leg by exercise. The present study also demonstrated that the plasma norepinephrine concentrations were elevated by exercise in the femoral veins of both the working and nonworking legs, suggesting that the sympathetic nerve activity was augmented in both legs during exercise. Therefore, the present study demonstrates the possibility that the increase in production of ET-1 in nonworking muscles may cause vasoconstriction and hence decrease blood flow in nonworking muscles through its direct vasoconstrictive action or through an indirect effect of ET-1 to enhance vasoconstrictions to norepinephrine and that these responses may be helpful in increasing blood flow in working muscles. We propose that endogenous ET-1 contributes to the exercise-induced redistribution of blood flow in muscles.

    DOI PubMed

  • 運動部強化合宿における血漿 sulfhydryl group(SH基)の変動

    斎藤, 実, 稲山, 貴代, 斉藤, 文大, 前田, 清司, 松田, 光生

    臨床スポーツ医学 = The journal of clinical sports medicine   13 ( 12 ) 1425 - 1429  1996年12月  [査読有り]

  • 1068 Endothelin-1 Level in the hypertrophied heart of Tsukuba Hypertensive Mice

    Maki, Shinichi, Miyauchi, Takashi, Sakai, Satoshi, Maeda, Seiji, Yamaguchi, Iwao, Sugiyama, Fumihiro, Goto, Katsutoshi, Fukamizu, Akiyoshi, Murakami, Kazuo, Sugishita, Yasuro

    Japanese circulation journal   60 ( 7 ) 476  1996年06月  [査読有り]

  • 1068 つくば高血圧マウス(ヒトレニンおよびアンジオテンシノーゲン遺伝子導入マウス)の肥大心における組織エンドセリン-1レベルの上昇

    牧, 真一, 宮内, 卓, 酒井, 俊, 前田, 清司, 山口, 巌, 杉下, 靖郎, 杉山, 文博, 後藤, 勝年, 深水, 昭吉, 村上, 和雄

    Japanese circulation journal   60 ( 0 ) 315  1996年02月

  • 0498 運動時にエンドセリン-1の動静脈血漿濃度較差は非活動肢で増大し, 活動肢では変化しない : 片足自転車エルゴメーター負荷での検討

    前田, 清司, 斎藤, 実, 松田, 光生, 宮内, 卓, 坂根, みち子, 牧, 真一, 杉下, 靖郎, 後藤, 勝年

    Japanese circulation journal   60 ( 0 ) 172  1996年02月

  • Plasma endothelin-1 level in athletes after exercise in a hot environment: exercise-induced dehydration contributes to increases in plasma endothelin-1

    Seiji, Maeda, Takashi, Miyauchi, Takahiro, Waku, Yasuko, Koda, Ichiro, Kono, Katsutoshi, Goto, Mitsuo, Matsuda

    Life Sciences   58 ( 15 ) 1259 - 1268  1996年01月  [査読有り]

     概要を見る

    We investigated whether dehydration due to exercise contributes to the increase in plasma endothelin-1 (ET-1) concentration. We measured the plasma concentration of ET-1 before and after exercise in a hot environment (about 30 degrees C). Five male intercollegiate Kendo (Japanese fencing) players entered the present study. Each athlete participated in 15 min of Kendo fighting, followed by 5 min of rest and another 15 min of Kendo fighting (i.e., total exercise 30 min), with or without oral intake of 700 ml of water. Body weight and left atrial diameter, a parameter that reflects changes in circulating plasma volume, were significantly decreased after exercise under both conditions. However, the decreases in both values were significantly greater after exercise without water intake than after exercise with water intake, indicating that dehydration and decreased circulating plasma volume were more marked after exercise without water intake. The extent of the increase in plasma ET-1 concentration appeared to be closely related to the extent of exercise-induced dehydration; the greater the dehydration, the greater the increase in plasma ET-1 concentration. These findings suggest that e

  • 118.内因性endothelin-1の産生は運動時に非活動筋で増大する

    前田, 清司, 宮内, 卓, 坂根, みち子, 斎藤, 実, 牧, 真一, 松田, 光生

    体力科學   44 ( 6 ) 665  1995年12月

  • 0077 運動負荷試験による血漿エンドセリン濃度の変動 : 血漿エンドセリン-1と-3濃度の異なる変動パターン

    前田, 清司, 松田, 光生, 宮内, 卓, 杉下, 靖郎, 後藤, 勝年

    Japanese circulation journal   59 ( 0 ) 62  1995年03月

  • Cardiovascular Function During Kendo Exercise in a Hot Environment

    Takahiro Waku, Seiji Maeda, Ichiro Kono, Yasuko Koda, Mitsuo Matsuda

    Japanese Journal of Physical Fitness and Sports Medicine   44 ( 2 ) 239 - 249  1995年  [査読有り]

     概要を見る

    A study was carried out to examine the effects of water replacement on cardiovascular function during kendo practice in a hot environment. Five male college kendoists performed moderately severe 30-min kendo practice at a WBGT index of about 27°C with and without water intake. For water replacement, the subjects ingested 700 ml water (500 ml before exercise and 200 ml at 15 min after the start of exercise). Under both conditions, body weight was decreased significantly, and hematocrit and serum total protein concentration were increased significantly after the exercise. With water replacement, the body weight loss induced by the exercise was similar to that under water deprivation. However, the decrease in body weight from the basal body weight, i. e. body weight measured before water intake, was significantly less with water replacement than under water deprivation. There were no significant differences in the percentage increases of hematocrit and serum total protein concentration between the two conditions, although the percentage change in plasma vasopressin concentration was significantly lower with water replacement than without. In the subjects deprived of water, the left ventricular end-diastolic dimension and left atrial dimension were significantly reduced after the exercise, and stroke volume, ejection fraction, and fractional shortening were also decreased significantly. The ratio of left ventricular end-systolic wall stress to left ventricular end-systolic volume index was increased significantly after the exercise without water intake. With water replacement, however, the percentage decreases in cardiac dimensions, stroke volume, ejection fraction, and fractional shortening were significantly lower than those under water deprivation. There was no significant change in the ratio of left ventricular end-systolic wall stress to left ventricular end-systolic volume index before and after the exercise with water intake. It is suggested that 700 ml water replacement before and during kendo exercise in a hot environment prevents depletion of stroke volume and deterioration of cardiovascular function, although it might not improve significantly the plasma volume loss after exercise. © 1995, The Japanese Society of Physical Fitness and Sports Medicine. All rights reserved.

    DOI

  • 高温環境下における剣道の稽古時の血行動態 ―水分摂取の影響―

    和久貴洋, 前田清司, 河野一郎, 香田泰子, 松田光生

    体力科学   44   239-250  1995年01月  [査読有り]

  • PLASMA ENDOTHELIN-1 LEVELS AFTER EXERCISE IN PATIENTS WITH CONGENITAL HEART-DISEASE

    S ISHIKAWA, T MIYAUCHI, S SAKAI, H SUNAGAWA, S HONDA, S MAEDA, M MATSUDA, YAMAGUCHI, I, K GOTO, Y SUGISHITA

    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   26   S491 - S493  1995年  [査読有り]

     概要を見る

    We have previously reported that plasma endothelin-1 (ET-1) levels were significantly increased after exercise in healthy athletes. In the present study, venous plasma ET-1 levels were measured to investigate whether the role of ET-1 during exercise differs between healthy athletes and patients with congenital heart disease. Seven patients (mean age 13 years) performed symptom-limited treadmill exercise (Bruce protocol). All patients were in class I of the NYHA functional classification. The mean end-exercise O-2 utilization was 32 ml/min/kg (166% of ventilatory threshold). Blood sampling was carried out in the seated position. The plasma ET-1 level was 1.21 pg/ml before exercise and did not alter immediately after or 30 min after exercise. The plasma level of norepinephrine was markedly elevated immediately after exercise and returned to the basal level 30 min after exercise. The present study demonstrated that exercise failed to alter plasma ET-1 levels in patients with congenital heart disease.

  • 37.運動負荷による血漿エンドセリン-3濃度の変動

    前田, 清司, 宮内, 卓, 後藤, 勝年, 松田, 光生

    体力科學   43 ( 6 ) 525  1994年12月

  • 運動負荷による血漿endothelin-1濃度の変動 : Ventilatory threshold上下での異なった運動強度での検討 : 第58回日本循環器学会学術集会

    前田, 清司, 松田, 光生, 宮内, 卓, 杉下, 靖郎, 後藤, 勝年

    Japanese circulation journal   58 ( 0 ) 501  1994年03月

  • Alteration of plasma endothelin-1 by exercise at intensities lower and higher than ventilatory threshold

    S. Maeda, T. Miyauchi, K. Goto, M. Matsuda

    Journal of Applied Physiology   77 ( 3 ) 1399 - 1402  1994年  [査読有り]

     概要を見る

    The purpose of this study was to investigate whether the release of endothelin-1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, is induced by exercise. Venous plasma concentrations of ET-1 were measured by sandwich-enzyme immunoassay before and after endurance exercise with a cycle ergometer at different intensities. Male intercollegiate athletes participated in the study and performed cycle ergometer exercise of 30 min duration at intensities of 90 or 130% of their individual ventilatory threshold (VT). The plasma concentration of ET-1 was slightly but significantly increased after exercise at 90% and markedly increased after exercise at 130% of individual VT. The increase in ET-1 was greatest 30 min after exercise at both intensities. It was first demonstrated that the plasma concentration of ET-1 was significantly increased after exercise: the greater the intensity, the greater the extent of the increase in plasma ET-1 concentration. However, the precise physiological roles of ET- 1 during exercise remain to be elucidated.

    DOI PubMed

  • 467.エルゴメーター運動負荷による血漿エンドセリン-11濃度の変動:運動強度との関連

    前田, 清司, 宮内, 卓, 後藤, 勝年, 松田, 光生

    体力科學   42 ( 6 ) 800  1993年12月

  • 高温環境下の運動と血漿endothelin-1濃度 : 脱水との関連 : ポスター発表 : 第57回日本循環器学会学術集会

    前田, 清司, 松田, 光生, 宮内, 卓, 杉下, 靖郎, 後藤, 勝年

    Japanese circulation journal   57 ( 0 ) 442  1993年03月

  • 先天性心疾患に伴う小児肺高血圧症患者の根治手術後の血漿endothelin-1濃度の変動 : 肺循環動態の改善との関連 : 口述発表 : 第57回日本循環器学会学術集会

    石川, 司朗, 総崎, 直樹, 岩尾, 初雄, 砂川, 博史, 本田, 悳, 宮内, 卓, 酒井, 俊, 山口, 巌, 杉下, 靖郎, 前田, 清司, 後藤, 勝年, 上野, 逸夫, 鈴木, 伸宏

    Japanese circulation journal   57 ( 0 ) 175  1993年03月

  • 水泳トレーニングラット心臓におけるカルシウムチャンネル機能の変化 : 口述発表 : 第57回日本循環器学会学術集会

    前田, 清司, 松田, 光生, 宮内, 卓, 杉下, 靖郎, 後藤, 勝年

    Japanese circulation journal   57 ( 0 ) 163  1993年03月

  • 膵臓ホルモンamylinの摘出ラット心房に及ぼす変時変力作用 : amylinはカルシトニン遺伝子関連ペプチドの陽性変時作用を拮抗する : 口述発表 : 第57回日本循環器学会学術集会

    宮内, 卓, 酒井, 俊, 山口, 巌, 杉下, 靖郎, 前田, 清司, 後藤, 勝年

    Japanese circulation journal   57 ( 0 ) 135  1993年03月

  • 肺高血圧症ラットの肺高血圧進展における内因性エンドセリンの関与 : エンドセリン受容体遮断薬持続投与による肺高血圧症の改善 : 口述発表 : 第57回日本循環器学会学術集会

    宮内, 卓, 酒井, 俊, 山口, 巌, 杉下, 靖郎, 寄兼, 良輔, 桜井, 武, 前田, 清司, 後藤, 勝年, 岡田, 恵, 錦辺, 優, 矢野, 光夫

    Japanese circulation journal   57 ( 0 ) 29  1993年03月

  • 84.高温環境下における運動時の血行動態 : 水分摂取の影響

    和久, 貴洋, 松田, 光生, 前田, 清司, 宮内, 卓, 松崎, 守利

    体力科學   41 ( 6 ) 692  1992年12月

  • 63.長期運動負荷ラットの心筋内副交感神経 : 右心房と左心房における終末部機能の違い

    前田, 清司, 松田, 光生, 松崎, 守利, 水上, 春美, 白倉, 寛, 小林, 和彦, 宮内, 卓, 後藤, 勝年, 杉下, 靖郎

    体力科學   41 ( 6 ) 682  1992年12月

  • 042 808 高温環境下の運動前後における血漿エンドセリン濃度の変動 : 脱水との関連

    前田, 清司, 宮内, 卓, 和久, 貴洋, 河野, 一郎, 松田, 光生

    日本体育学会大会号   0 ( 43 ) 308  1992年10月

  • 長期水泳トレーニング後のラット摘出右心房標本におけるCa^<2+>チャンネル作動薬及びβ_1アドレナリン受容体作動薬の反応性

    前田, 清司, 宮内, 卓, 後藤, 勝年, 杉下, 靖郎, 松田, 光生

    体力科學   41 ( 5 ) 595 - 597  1992年10月

  • 血液透析患者におけるエンドセリン変換酵素活性の変化 : サンドイッチ酵素免疫測定法を用いた健常人及び透析患者のエンドセリンファミリーの血中濃度

    宮内, 卓, 山口, 巌, 杉下, 靖郎, 山田, 吾郎, 前田, 清司, 真崎, 知生, 後藤, 勝年, 松本, 寛和, 鈴木, 伸宏

    Japanese circulation journal   56 ( 0 ) 148  1992年03月

  • 水泳トレーニングラット心臓における心筋内自律神経(交感・副交感神経)終末部機能の変化 : intracardiac nerve stimulation法による検討

    前田, 清司, 松田, 光生, 宮内, 卓, 杉下, 靖郎, 後藤, 勝年

    Japanese circulation journal   56 ( 0 ) 74  1992年03月

  • 長期水泳トレーニング後のラット摘出右心房標本におけるCa2+チャンネル作動薬及びβ1アドレナリン受容体作動薬の反応性

    前田清司, 宮内卓, 後藤勝年, 杉下靖郎, 松田光生

    体力科学   41   595-597  1992年01月  [査読有り]

  • ヒト血漿エンドセリン濃度 : 剣道競技者及び透析患者における検討

    前田, 清司, 松田, 光生, 和久, 貴洋, 宮内, 卓, 杉下, 靖郎, 後藤, 勝年, 眞崎, 知生, 鈴木, 伸宏

    体力科學   40 ( 6 ) 582  1991年12月

  • 高温環境下における剣道の稽古時の血行動態 : 水分摂取の影響

    和久, 貴洋, 松田, 光生, 河野, 一郎, 芳賀, 脩光, 香田, 泰子, 三輪, 一義, 水上, 春美, 松崎, 守利, 前田, 清司, 宮内, 卓, 飯田, 要

    体力科學   40 ( 6 ) 558 - 558  1991年12月

    CiNii

▼全件表示

書籍等出版物

  • はじめてとりくむ身体活動支援

    前田清司, 崔英珠( 担当: 分担執筆,  担当範囲: 疾患予防と改善のための身体活動のエビデンス:高血圧)

    2019年

  • 運動生理学大事典

    前田,清司( 担当: 分担執筆,  担当範囲: 循環器系と運動)

    2017年09月 ISBN: 9784890134779

  • たくましい心とかしこい体

    Maeda,Seiji( 担当: 分担執筆,  担当範囲: スポーツと血管の科学)

    大修館書店  2016年 ISBN: 9784469267983

  • 透析運動療法

    Maeda,Seiji( 担当: 分担執筆,  担当範囲: 動脈硬化と運動療法)

    医薬ジャーナル社  2016年 ISBN: 9784753228195

  • TAURINE 9

    Ra, Song-Gyu, Akazawa, Nobuhiko, Choi, Youngju, Matsubara, Tomoko, Oikawa, Satoshi, Kumagai, Hiroshi, Tanahashi, Koichiro, Ohmori, Hajime, Maeda, Seiji( 担当: 分担執筆,  担当範囲: Taurine Supplementation Reduces Eccentric Exercise-Induced Delayed Onset Muscle Soreness in Young Men)

    SPRINGER-VERLAG BERLIN  2015年 ISBN: 9783319151267

  • スポーツバイオ科学と先進スポーツギアの開発

    Maeda,Seiji( 担当: 分担執筆,  担当範囲: 運動と血管内皮由来生理活性物質)

    2015年

  • メディカルフィットネスQ&A

    前田,清司( 担当: 分担執筆,  担当範囲: 高血圧の人が塩分摂取を控えて運動を習慣化しても、血圧が下がらない場合があるのはなぜでしょうか)

    2014年

  • メディカルフィットネスQ&A

    前田,清司( 担当: 分担執筆,  担当範囲: 高血圧の人が塩分摂取を控えて運動を習慣化しても、血圧が下がらない場合があるのはなぜでしょうか)

    2014年

  • メディカルフィットネスQ&A

    前田,清司( 担当: 分担執筆,  担当範囲: 高血圧の人でも運動によって血管は軟らかくなりますか)

    2014年

  • メディカルフィットネスQ&A

    前田,清司( 担当: 分担執筆,  担当範囲: 高血圧の改善に及ぼす運動の効果はどの程度なのでしょうか)

    2014年

  • メディカルフィットネスQ&A

    前田,清司( 担当: 分担執筆,  担当範囲: 高血圧の人が塩分摂取を控えて運動を習慣化しても、血圧が下がらない場合があるのはなぜでしょうか)

    2014年

  • メディカルフィットネスQ&A

    前田,清司( 担当: 分担執筆,  担当範囲: 高血圧の改善に及ぼす運動の効果はどの程度なのでしょうか)

    2014年

  • 疾病予防・健康増進のための分子スポーツ医学

    前田,清司( 担当: 分担執筆,  担当範囲: 運動習慣と動脈の老化)

    2013年06月

  • スポーツ生理学

    前田,清司( 担当: 分担執筆,  担当範囲: スポーツと遺伝子)

    2013年02月

  • スポーツ生理学

    前田,清司( 担当: 分担執筆,  担当範囲: スポーツと循環)

    2013年02月

  • 身体運動と呼吸・循環機能

    前田,清司( 担当: 分担執筆,  担当範囲: 血管内皮細胞)

    2012年07月

  • エクササイズ科学

    前田,清司( 担当: 分担執筆,  担当範囲: 高血圧症予防と改善に向けたエクササイズ)

    文光堂  2012年02月

  • エクササイズ科学

    前田,清司( 担当: 分担執筆,  担当範囲: 高血圧症予防と改善に向けたエクササイズ)

    文光堂  2012年02月

  • 動脈スティフネスと運動強度

    大槻毅, 前田清司( 担当: 監修)

    臨床スポーツ医学  2011年01月

  • 運動と血管内皮の働き

    前田清司( 担当: 監修)

    体育の科学  2011年01月

  • 循環器疾患:疾患モデルの作製と利用

    前田清司, 宮内裕美, 酒井俊, 宮内卓( 担当: 単著)

    エル・アイ・シー  2010年01月

  • Influence of regular exercise on arterial stiffness and endothelium

    Seiji, Maeda( 担当: 監修)

    Advances in Exercise and Sports Physiology  2010年01月

  • 身体トレーニング

    前田清司( 担当: 単著)

    真興交易医書出版  2009年01月

  • 保健指導に求められる個別運動プログラム作成・実践ガイド

    前田清司, 大槻毅( 担当: 単著)

    杏林書院  2009年01月

  • 運動と血管内皮

    前田清司( 担当: 監修)

    体育の科学  2009年01月

  • 動脈硬化予防と改善のための運動・身体活動

    前田清司( 担当: 監修)

    臨床栄養  2009年01月

  • 生活機能の観点からみた動脈硬化の予防:運動による予防のメカニズム

    前田清司( 担当: 監修)

    臨床スポーツ医学  2009年01月

  • 血管由来のホルモンと運動

    前田清司( 担当: 監修)

    体育の科学  2009年01月

  • Exercise and Women's Health: New Research

    Takeshi, Otsuki, Seiji, Maeda( 担当: 単著)

    NOVA Science Publishers  2008年01月

  • 中心動脈伸展性の加齢変化と運動の効果

    前田清司( 担当: 監修)

    動脈硬化予防  2008年01月

  • Exercise training-associated changes in arterial stiffness and endothelium-derived vasoactive factors

    Takeshi, Otsuki, Seiji, Maeda( 担当: 監修)

    Current Hypertension Reviews  2008年01月

  • スポーツの科学

    前田清司( 担当: 単著)

    日本学術協力財団  2007年01月

  • 循環Ⅱ:運動時の調節と適応

    前田清司( 担当: 単著)

    ナップ  2007年01月

  • 高血圧(第3版)上巻

    前田清司, 宮内卓, 後藤勝年( 担当: 単著)

    日本臨床社  2006年01月

  • Annual Review 糖尿病・代謝・内分泌 2006

    前田清司, 宮内卓( 担当: 単著)

    中外医学社  2006年01月

  • 身体運動と心血管系機能

    前田清司( 担当: 監修)

    学術の動向  2006年01月

  • Individual variations of exercise training-induced physiological effects and genetic factor

    Seiji, Maeda, Haruka, Murakami, Shinya, Kuno, Mitsuo, Matsuda, Kazuo, Murakami( 担当: 監修)

    International Journal of Sport and Health Sciences  2006年01月

  • 新・心臓病診療プラクティス 6

    宮内卓, 前田清司( 担当: 単著)

    文光堂  2005年01月

  • エンドセリンとエンドセリン拮抗薬

    前田清司, 宮内卓, 後藤勝年( 担当: 監修)

    血管  2005年01月

  • トレーニングに対する血管応答

    前田清司( 担当: 監修)

    体育の科学  2005年01月

  • 高血圧と血管内皮障害

    前田清司, 宮内卓( 担当: 監修)

    糖尿病  2005年01月

  • 運動トレーニングによる心臓の適応機序:遺伝子レベルから

    家光素行, 前田清司, 宮内卓( 担当: 監修)

    筑波大学体育科学系紀要  2005年01月

  • 遺伝子からみたスケール -運動と遺伝子-

    前田清司, 家光素行( 担当: 監修)

    体育の科学  2004年01月

  • 運動・身体活動と血管内皮由来因子

    前田清司, 松田光生( 担当: 監修)

    筑波大学体育科学系紀要  2004年01月

  • 運動刺激と血管内皮

    前田清司( 担当: 監修)

    体育の科学  2002年01月

  • 新運動生理学

    前田清司( 担当: 単著)

    真興交易医書出版  2001年01月

  • 運動と循環

    前田清司( 担当: 単著)

    ナップ  2001年01月

  • 運動とホルモン

    前田清司( 担当: 単著)

    ナップ  2001年01月

  • 心臓における生命現象の分子生物学

    前田清司, 酒井俊, 宮内卓( 担当: 単著)

    メデイカルレビュー社  2001年01月

  • 心不全における血管内皮機能

    前田清司, 酒井俊, 宮内卓( 担当: 監修)

    Heart View  2001年01月

  • 運動と内皮由来血管作動性物質 -エンドセリンと一酸化窒素(NO)-

    前田清司, 宮内卓, 松田光生( 担当: 監修)

    運動生化学  2001年01月

  • 高齢者の生活機能増進法

    前田清司, 柿山哲治, 松田光生( 担当: 単著)

    ナップ  2000年01月

▼全件表示

Misc

  • ボランティア主導型減量支援プログラムの体系的評価

    水島諒子, 中田由夫, 笹井浩行, 前田清司, 田中喜代次

    健康支援   23 ( 1 )  2021年

    J-GLOBAL

  • 行動変容技法を活用した介入が日本人男性の身体活動量に及ぼす効果

    辻本 健彦, 若葉 京良, 水島 諒子, 熊谷 仁, 吉川 徹, 妙圓園 香苗, 前田 清司, 田中 喜代次

    健康支援 = Japanese journal of health promotion   22 ( 2 ) 155 - 165  2020年09月

    CiNii

  • The Impact Of Pms And Pmdd On Physical Performance In Female Track And Field Athletes

    Reiko Momma, Yuriko Tochigi, Ai Hamasaki, Koichiro Tanahashi, Akari Takahashi, Tomohito Sato, Atsumu Yokota, Noboru Mesaki, Seiji Maeda

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   51 ( 6 ) 764 - 764  2019年06月

    研究発表ペーパー・要旨(国際会議)  

    DOI

  • Does sport discipline at a young age influence the incidence of hypertension?: J-Fit+study(和訳中)

    Kumagai Hiroshi, Someya Yuki, Yoshioka Masaki, Miyamoto-Mikami Eri, Choi Youngju, Kohmura Yoshimitsu, Suzuki Koya, Machida Shuichi, Naito Hisashi, Maeda Seiji, Fuku Noriyuki

    The Journal of Physiological Sciences   69 ( Suppl.1 ) S195 - S195  2019年06月

  • 減量プログラム参加者における心理的ストレス反応の変化と体重減少との関連

    水島諒子, 水島諒子, 中田由夫, 笹井浩行, 左シンウ, 前田清司, 黒谷佳代, 瀧本秀美, 田中喜代次

    栄養学雑誌   77 ( 5 Supplement )  2019年

    J-GLOBAL

  • 生体マウスにおけるDicerの欠損は持久性運動による骨格筋適応に影響しない

    及川哲志, 李ミンジョン, 本橋紀夫, 前田清司, 秋本崇之

    日本筋学会学術集会プログラム・抄録集   5th  2019年

    J-GLOBAL

  • High Aerobic Fitness And Muscular Strength Offset Aging-induced Deterioration Of Male Sexual Function

    Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Nobuhiko Akazawa, Seiji Maeda

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   50 ( 5 ) 542 - 542  2018年05月

    研究発表ペーパー・要旨(国際会議)  

  • 行動変容理論を活用した低頻度開催型運動プログラムの長期的効果

    辻本健彦, 田中喜代次, 前田清司, 若葉京良, 王震男, 吉川徹, 水島諒子, 妙圓園香苗, 熊谷仁

    健康支援   20 ( 1 )  2018年

    J-GLOBAL

  • 身体能力と加齢腎

    小崎恵生, 小崎恵生, 池森敦子, 池森敦子, 柴垣有吾, 前田清司

    日本腎臓リハビリテーション学会学術集会プログラム・抄録集   8th   100  2018年

    J-GLOBAL

  • Effects Of Lifestyle Modifications On Serum Testosterone Levels In Overweight And Obese Men

    Hiroshi Kumagai, Toru Yoshikawa, Kanae Myoenzono, Tomoko Kaneko, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   49 ( 5 ) 1058 - 1058  2017年05月

    研究発表ペーパー・要旨(国際会議)  

    DOI

  • Vigorous-Intensity Physical Activity May Improve Central Aortic Pressure Response to Glucose Loading in Overweight/Obese Men

    Toru Yoshikawa, Hiroshi Kumagai, Kanae Myoenzono, Tomoko Kaneko, Takehiko Tsujimoto, Kiyoji Tanaka, Seiji Maeda

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   49 ( 5 ) 808 - 808  2017年05月

    研究発表ペーパー・要旨(国際会議)  

    DOI

  • 持久力および筋力は成人男性における男性機能に関連する

    熊谷仁, 熊谷仁, 熊谷仁, 吉川徹, 吉川徹, 妙圓園香苗, 赤澤暢彦, 赤澤暢彦, 棚橋嵩一郎, 田川要, 小崎恵生, 小崎恵生, 前田清司

    日本運動生理学会大会プログラム・抄録集   25th  2017年

    J-GLOBAL

  • 中高齢者における有酸素性運動介入が脳血流動態および認知機能に与える影響

    濱崎愛, 赤澤暢彦, 赤澤暢彦, 栃木悠里子, 吉川徹, 妙圓園香苗, 西村真琴, 棚橋嵩一郎, 前田清司

    脳科学とリハビリテーション   17  2017年

    J-GLOBAL

  • 住民主導による健康減量教室の質的分析による課題抽出

    水島諒子, 笹井浩行, 笹井浩行, 中田由夫, 前田清司, 田中喜代次

    健康支援   19 ( 1 )  2017年

    J-GLOBAL

  • 住民主導型減量教室への参加に伴う同居家族の食行動の変化

    水島諒子, 笹井浩行, 笹井浩行, 中田由夫, 左シンウ, 前田清司, 田中喜代次

    日本栄養・食糧学会大会講演要旨集   71st  2017年

    J-GLOBAL

  • 中高齢者における握力と腎内血管抵抗指数(RRI)の関連性

    小崎恵生, 池森(上條)敦子, 池森(上條, 敦子, 菅谷健, 菅谷健, 棚橋嵩一郎, 熊谷仁, 澤野友里子, 大須賀洋祐, 田中喜代次, 木村健二郎, 柴垣有吾, 前田清司

    日本腎臓リハビリテーション学会学術集会プログラム・抄録集   7th   186  2017年

    J-GLOBAL

  • 肥満男性における生活習慣改善が血漿アミノ酸濃度に及ぼす影響

    妙圓園 香苗, 吉川 徹, 熊谷 仁, 蘇 リナ, 辻本 健彦, 田中 喜代次, 前田 清司

    体力科学   65 ( 4 ) 445 - 445  2016年08月

  • Influence of Blood Flow Velocity on Arterial Distensibility of Carotid Artery in Healthy Men

    Jun Sugawara, Tsubasa Tomoto, Seiji Maeda

    FASEB JOURNAL   30  2016年04月

    研究発表ペーパー・要旨(国際会議)  

  • The Effect of Left Ventricular-Central Artery Coupling on Cerebrovascular Hemodynamics: Insights from Lower Body Negative Pressure

    Tsubasa Tomoto, Tomoko Imai, Shigehiko Ogoh, Seiji Maeda, Jun Sugawara

    FASEB JOURNAL   30  2016年04月

    研究発表ペーパー・要旨(国際会議)  

  • Aerobic exercise training increases testosterone production in the testis in OLETF rats

    Hiroshi Kumagai, Asako Zempo-Miyaki, Kanae Myoenzono, Seiji Maeda

    FASEB JOURNAL   30  2016年04月

    研究発表ペーパー・要旨(国際会議)  

     概要を見る

    0

  • 下半身陰圧負荷刺激が大動脈‐脳循環伝達特性に与える影響:周波数領域解析による検討

    菅原順, 東本翼, 東本翼, 今井智子, 前田清司, 小河繁彦

    体力科学   64 ( 6 ) 587 - 587  2015年12月

    J-GLOBAL

  • 運動と予防医療

    田村 好史, 前田 清司, 宮地 元彦, 真田 樹義

    予防医療Aggressive   2 ( 3 ) 150 - 158  2015年10月

  • Effect Of Summer Camp Training On Sympathetic Nerve Activity And Artery Stiffness In Endurance Runner.

    Hiroyuki Sasaki, Tsubasa Tomoto, Ai Hirasawa, Tomoko Imai, Seiji Maeda, Jun Sugawara, Shigehiko Ogoh

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   47 ( 5 ) 53 - 53  2015年05月

    研究発表ペーパー・要旨(国際会議)  

    DOI

  • Resting brachial artery shear rate is associated with exercise habituation in middle aged and older adults

    Koichiro Tanahashi, Nobuhiko Akazawa, Youngju Choi, Keisei Kosaki, Jun Sugawara, Seiji Maeda

    FASEB JOURNAL   29  2015年04月

    研究発表ペーパー・要旨(国際会議)  

  • Effect of Left Ventricular-Central Artery Coupling on Cerebrovascular Hemodynamics: Insights from Endurance Training Intervention

    Tsubasa Tomoto, Jun Sugawara, Yoshie Nogami, Kazutaka Aonuma, Seiji Maeda

    FASEB JOURNAL   29  2015年04月

    研究発表ペーパー・要旨(国際会議)  

  • Effect of acute lower leg heating on aortic pulse wave reflection in postmenopausal women

    Keisei Kosaki, Jun Sugawara, Nobuhiko Akazawa, Tomoko Matsubara, Asako Zempo-Miyaki, Seiji Maeda

    FASEB JOURNAL   29  2015年04月

    研究発表ペーパー・要旨(国際会議)  

  • ヘパトカインセレノプロテインP血中濃度による運動療法抵抗性の予知に関する検討

    御簾 博文, 田中 睦, 斎藤 芳郎, 石井 清朗, 竹下 有美枝, 金森 岳広, 赤澤 暢彦, 前田 清司, 竹越 一博, 金子 周一, 篁 俊成

    糖尿病   58 ( Suppl.1 ) S - 390  2015年04月

  • 肥満者における生活習慣改善が動脈スティフネスと炎症性因子に及ぼす影響

    熊谷仁, 膳法亜沙子, 吉川徹, 妙圓園香苗, 蘇リナ, 西保岳, 田中喜代次, 前田清司

    体力科学   64 ( 6 )  2015年

    J-GLOBAL

  • 運動トレーニングがメンタルヘルスおよび動脈スティフネスに及ぼす影響-生化学的アプローチによる検討-

    赤澤暢彦, 及川哲志, 熊谷仁, 前田清司

    若手研究者のための健康科学研究助成成果報告書   ( 30 )  2015年

    J-GLOBAL

  • クルクミン研究の最前線 生活習慣と動脈硬化度-クルクミン,運動

    前田清司, 赤澤暢彦

    Foods & Food Ingredients Journal of Japan   220 ( 4 )  2015年

    J-GLOBAL

  • 短期間の高強度持久性トレーニングが中心動脈伸展性および心機能に及ぼす影響

    東本翼, 東本翼, 平澤愛, 今井智子, 今井智子, 前田清司, 小河繁彦, 菅原順

    体力科学   63 ( 6 ) 647 - 647  2014年12月

    DOI J-GLOBAL

  • Effects of Short-term Vigorous Endurance Training on Central Arterial Stiffness in Endurance Athletes

    Tsubasa Tomoto, Jun Sugawara, Ai Hirasawa, Tomoko Imai, Toshiyuki Sakai, Seiji Maeda, Shigehiko Ogoh

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   46 ( 5 ) 324 - 324  2014年05月

    研究発表ペーパー・要旨(国際会議)  

  • Blood pressure regulation II: what happens when one system must serve two masters-oxygen delivery and pressure regulation?

    Masashi Ichinose, Seiji Maeda, Narihiko Kondo, Takeshi Nishiyasu

    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY   114 ( 3 ) 451 - 465  2014年03月

    書評論文,書評,文献紹介等  

     概要を見る

    During high-intensity dynamic exercise, O-2 delivery to active skeletal muscles is enhanced through marked increases in both cardiac output and skeletal muscle blood flow. When the musculature is vigorously engaged in exercise, the human heart lacks the pumping capacity to meet the blood flow demands of both the skeletal muscles and other organs such as the brain. Vasoconstriction must therefore be induced through activation of sympathetic nervous activity to maintain blood flow to the brain and to produce the added driving pressure needed to increase flow to the skeletal muscles. In this review, we first briefly summarize the local vascular and neural control mechanisms operating during high-intensity exercise. This is followed by a review of the major neural mechanisms regulating blood pressure during high-intensity exercise, focusing mainly on the integrated activities of the arterial baroreflex and muscle metaboreflex. In high cardiac output situations, such as during high-intensity dynamic exercise, small changes in total peripheral resistance can induce large changes in blood pressure, which means that rapid and fine regulation is necessary to avoid unacceptable drops in blood pressure. To accomplish this rapid regulation, arterial baroreflex function may be modulated in various ways through activation of the muscle metaboreflex and/or other neural mechanisms. Moreover, this modulation of the arterial baroreflex may change over the time course of an exercise bout, or to accommodate changes in exercise intensity. Within this model, integration of arterial baroreflex modulation with other neural mechanisms plays an important role in cardiovascular control during high-intensity exercise.

    DOI

  • エンドセリンA/Bデュアル受容体遮断薬の心臓血管系と腎臓に対する効果 高血圧肥大心、糖尿病性心筋症、高血圧性血管障害のモデルにおいて

    宮内 裕美, 酒井 俊, ジェスミン・サブリナ, 下條 信威, 本間 覚, 前田 清司, 渡辺 重行, 青沼 和隆, 宮内 卓

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   2回   179 - 179  2013年05月

  • O-27 Is aerobic exercise capacity related to cerebral blood flow velocity in postmenopausal women?(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba)) :

    AKAZAWA Nobuhiko, CHOI Youngju, MIYAKI Asako, AJISAKA Ryuichi, MAEDA Seiji

    Advances in exercise and sports physiology   18 ( 4 ) 95 - 95  2013年

    CiNii

  • P-11 Effect of endurance exercise training on serum sex-hormoneslevels in obese adult men(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba)) :

    AJISAKA Ryuichi, NARUTO Takehiro, CHOI Youngju, MIYAKI Asako, AKAZAWA Nobuhiko, MAEDA Seiji, TANAKA Kiyoji

    Advances in exercise and sports physiology   18 ( 4 ) 106 - 106  2013年

    CiNii

  • Effects Of The Combined Treatment Of Aerobic Exercise Training And Curcumin Intake On Arterial Function

    Nobuhiko Akazawa, Youngju Choi, Asako Miyaki, Jun Sugawara, Ryuichi Ajisaka, Seiji Maeda

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   44   385 - 385  2012年05月

    研究発表ペーパー・要旨(国際会議)  

  • エンドセリンおよび前駆体ビッグエンドセリンの血中濃度の検討と受容体遮断薬ボセンタンの反応 循環器患者と健常人

    宮内 裕美, 前田 清司, 酒井 俊, 菅原 順, 下條 信威, ジェスミン・サブリナ, 本間 覚, 渡辺 重行, 青沼 和隆, 宮内 卓

    日本薬学会年会要旨集   132年会 ( 3 ) 175 - 175  2012年03月

  • エンドセリンおよび前駆体ビッグエンドセリンのヒトにおける血中濃度および受容体A/B遮断薬ボセンタンの反応性

    宮内 卓, 前田 清司, 宮内 裕美, 酒井 俊, 菅原 順, 下條 信威, ジェスミン・サブリナ, 本間 覚, 渡辺 重行, 青沼 和隆

    血管   35 ( 1 ) 31 - 31  2012年01月

  • タウリンとBCAAの併用摂取による伸張性運動前後の血漿アミノ酸濃度の変化

    羅成圭, 宮崎照雄, 石倉恵介, 鈴木隆文, 前田清司, 宮川俊平, 大森肇

    体力科学   60 ( 6 ) 699 - 699  2011年12月

    J-GLOBAL

  • 骨粗鬆症モデルラットにおけるDHEA投与は海綿骨主体の脛骨近位部における性ホルモン関連合成酵素を活性化させる

    朴 鐘薫, 相澤 勝治, 家光 素行, 秋本 崇之, 佐藤 幸治, 縣 右門, 前田 清司, 江澤 郁子, 麻見 直美

    Osteoporosis Japan   19 ( Suppl.1 ) 300 - 300  2011年11月

  • 動脈スティフネスと運動強度 (特集 運動強度とトレーニング効果--健康支援における実際)

    大槻 毅, 前田 清司

    臨床スポーツ医学   28 ( 10 ) 1089 - 1092  2011年10月

    CiNii

  • The combined effect of taurine with BCAA on the delayed-onset-muscle-soreness and damages after eccentric exercise-a double-blind study

    Song-Gyu Ra, Teruo Miyazaki, Keisuke Ishikura, Takafumi Suzuki, Seiji Maeda, Shumpei Miyakawa, Yasushi Matsuzaki, Hajime Ohmori

    AMINO ACIDS   41   S85 - S85  2011年07月

    研究発表ペーパー・要旨(国際会議)  

  • Circulating endothelial progenitor cells in strength-trained men

    Mutsuko Yoshizawa, Seiji Maeda, Youngju Choi, Nobutake Shimojo, Hidehiko Komine

    FASEB JOURNAL   25  2011年04月

    研究発表ペーパー・要旨(国際会議)  

  • The effects of regular endurance exercise on IL-6 and the sympathetic nervous system

    Hidehiko Komine, Mutsuko Yoshizawa, Seiji Maeda, Nobutake Shimojo, Yohei Takai, Nobuhiko Akazawa, Takashi Yokoi

    FASEB JOURNAL   25  2011年04月

    研究発表ペーパー・要旨(国際会議)  

  • 循環器患者および健常人におけるエンドセリンおよび前駆体ビッグエンドセリンの血中濃度の検討と受容体遮断薬ボセンタンの効果

    宮内 裕美, 前田 清司, 菅原 順, 下條 信威, 酒井 俊, ジェスミン・サブリナ, 本間 覚, 渡辺 重行, 青沼 和隆, 宮内 卓

    日本薬学会年会要旨集   131年会 ( 4 ) 316 - 316  2011年03月

  • Effects of regular endurance exercise on brachial blood flow response to mental stress

    Hidehiko Komine, Yohei Takai, Nobuhiko Akazawa, Seiji Maeda, Mutsuko Yoshizawa, Jun Sugawara, Takashi Yokoi

    FASEB JOURNAL   24  2010年04月

    研究発表ペーパー・要旨(国際会議)  

  • 肺高血圧患者と健常中高齢者におけるエンドセリン遮断薬ボセンタンの通常用量と高用量の投与による血管反応

    宮内 裕美, 前田 清司, 下條 信威, 酒井 俊, 本間 覚, 渡辺 重行, 青沼 和隆, 宮内 卓

    日本薬学会年会要旨集   130年会 ( 4 ) 292 - 292  2010年03月

  • Epicardial fat tissue: Relationship with cardiovascular fitness in men

    KIM Maeng‐Kyu, TANAKA Kiyoji, KIM Mi‐Ji, MATSUO Tomoaki, TOMITA Tsugio, OHKUBO Hiroyuki, MAEDA Seiji, AJISAKA Ryuichi

    Medicine and Sciences in Sports and Exercise   42 ( 3 ) 463 - 469  2010年

    DOI PubMed

  • 一過性運動における骨格筋局所のアンドロゲン代謝活性の変動と性差

    相澤 勝治, 家光 素行, 前田 清司, 佐藤 幸治, 大槻 毅, 牛田 多加志, 目崎 登, 秋本 崇之

    体力科学   57 ( 6 ) 657 - 657  2008年12月

  • Lactotripeptide improves central arterial compliance and vascular endothelial function in postmenopausal women

    Mutsuko Yoshizawa, Seiji Maeda, Asako Miyaki, Maiko Misono, Yoko Saito, Nobutake Shimcjo, Ryuichi Ajisaka, Hirofumi Tanaka

    JOURNAL OF AGING AND PHYSICAL ACTIVITY   16   S211 - S212  2008年07月

    研究発表ペーパー・要旨(国際会議)  

  • Strength exercise training accelerates initial and later heart rate recovery after exercise

    Otsuki Takeshi, Iemitsu Motoyuki, Saito Yoko, Tanimura Yuko, Ajisaka Ryuichi, Maeda Seiji

    JOURNAL OF AGING AND PHYSICAL ACTIVITY   16   S108  2008年07月  [査読有り]

  • Exercise training-associated changes in arterial stiffness and endothelium-derived vasoactive factors

    Takeshi Otsuki, Seiji Maeda

    Current Hypertension Reviews   4 ( 2 ) 143 - 149  2008年05月

    書評論文,書評,文献紹介等  

     概要を見る

    Age- and lifestyle-related arterial stiffening is a well-established independent cardiovascular risk factor. Previous studies have investigated the effects of exercise training on arterial stiffness. Aerobic exercise training reduces arterial stiffness. On the other hand, muscle-strengthening exercise, such as weight training, may stiffen central elastic arteries. However, the mechanism underlying exercise training-associated changes in arterial stiffness has not been fully elucidated. Adaptations of arteries to exercise training may, at least partly, be regulated by local factors. We have focused on endothelium-derived vasoactive factors, such as nitric oxide (NO) and endothelin (ET)-1, because the endothelium regulates vascular tone. NO has a significant vasodilatory effect, and ET-1 is a potent vasoconstrictor. Both factors have been reported to be affected by exercise training. This article reviews literature investigating the effects of exercise training on arterial stiffness and the role of endothelium-derived factors. We discuss here the role of endothelial function in exercise training-induced changes in arterial stiffness. © 2008 Bentham Science Publishers Ltd.

    DOI

  • Reduction in Alpha-Adrenergic Receptor-Mediated Vascular Tone Contributes to Improved Arterial Compliance with Endurance Training

    Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Takashi Yokoi, Seiji Maeda, Hirofumi Tanaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   40 ( 5 ) S11 - S11  2008年05月

    研究発表ペーパー・要旨(国際会議)  

  • Aerobic Exercise Training May Decrease Epicardial Fat and Improve Postexercise Heart Rate Recovery in Obese Men

    Maeng-Kyu Kim, Tsugio Tomita, Mi-Ji Kim, Tomoaki Matsuo, Hiroyuki Sasai, Seiji Maeda, Kiyoji Tanaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   40 ( 5 ) S282 - S282  2008年05月

    研究発表ペーパー・要旨(国際会議)  

  • Carotid artery compliance and systemic nitric oxide synthase inhibition in young healthy adults

    Jun Sugawara, Hidehiko Komine, Mitsuko Yoshizawa, Yoko Saito, Mariko Nakamura, Ryuichi Ajisaka, Seiji Maeda, Hirofumi Tanaka

    FASEB JOURNAL   22  2008年04月

    研究発表ペーパー・要旨(国際会議)  

  • 128. 一過性の水中運動と陸上運動が大動脈スティフネスに及ぼす影響(呼吸・循環,第62回日本体力医学会大会)

    野上 順子, 斉藤 陽子, 谷村 祐子, 野上 佳恵, 佐藤 幸治, 家光 素行, 大槻 毅, 前田 清司, 鯵坂 隆一

    体力科學   56 ( 6 )  2007年12月

    CiNii

  • 164. 高強度運動後のリンパ球減少に対する活性酸素、アポトーシスの関与(血液・免疫,第62回日本体力医学会大会)

    谷村 祐子, 清水 和弘, 松原 裕一, 田辺 解, 大槻 毅, 家光 素行, 前田 清司, 鰺坂 隆一

    体力科學   56 ( 6 )  2007年12月

    CiNii

  • 中高齢者における高感度CRPと運動耐容能の関連および運動トレーニング効果

    鰺坂 隆一, 村上 晴香, 前田 清司, 久野 譜也, 田中 喜代次, 渡辺 重行, 青沼 和隆, 山口 巖, 大槻 毅, 家光 素行, 曽根 博仁

    心臓   39 ( 2 ) 12 - 14  2007年04月

     概要を見る

    定期的服薬をしていない中高齢者を対象に、運動耐容能が血清高感度CRP濃度と関連を有するか、運動トレーニングが血清高感度CRP濃度を低下させ得るかについて検討した。運動耐容能は中年者182名、高齢者88名の計270名を対象に症候限界漸増自転車エルゴメータ運動負荷試験にて最高酸素摂取量またはdouble product breaking point(DPBP)時仕事率を測定した。運動トレーニング効果は中年者70名、高齢者99名の計169名を対象に自転車エルゴメータを用い、仕事率の80%強度で30分の運動を週5回の頻度で実施した。その結果、トレーニング前の血清高感度CRP濃度は高齢群が有意に高値であった。中年群において、血清高感度CRP濃度は身体活動量とは有意の関連は認めなかったが、最高酸素摂取量及びDPBP時仕事率とは有意の負の相関を認めた。一方、高齢群においては、血清高感度CRP濃度は身体活動量、最高酸素摂取量及びDPBP時仕事率のいずれとも有意の負の相関を認めた。中年群では、運動トレーニングにより身体活動量及び運動耐容能指標が有意に改善した。高齢群では、運動トレーニングにて身体活動量が有意に増加し、体格指数と血清高感度CRP濃度が有意に低下した。中年群、高齢群いずれにおいても、運動トレーニング前の血清高感度CRP濃度と運動トレーニングによるその変化量との間に有意の負の相関を認めた。

    DOI

  • Effect of Systemic Nitric Oxide Synthase Inhibition on Arterial Stiffness in Humans

    Jun Sugawara, Hidehiko Komine, Koichiro Hayashi, Mutsuko Yoshizawa, Takashi Yokoi, Takeshi Otsuki, Nobutake Shimojo, Takashi Miyauchi, Seiji Maeda, Hirofumi Tanaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   38 ( 5 ) S183 - S183  2006年05月

    研究発表ペーパー・要旨(国際会議)  

  • トレーニングに対する血管応答 (特集 運動生理学)

    前田 清司

    体育の科学   55 ( 12 ) 907 - 912  2005年12月

    CiNii

  • Exercise training improves aging-induced decrease of oxidative energy metabolic capacity in mitochondria through upregulation of nuclear respiratory factor-1 signaling by peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) alpha in the heart

    M Iemitsu, S Maeda, T Miyauchi

    CIRCULATION   112 ( 17 ) U889 - U889  2005年10月

    研究発表ペーパー・要旨(国際会議)  

  • Molecular Mechanisms Underlying Exercise Training-induced Reduction Of Aortic Stiffness

    Seiji Maeda, Motoyuki Iemitsu, Takashi Miyauchi, Shinya Kuno, Mitsuo Matsuda, Hirofumi Tanaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   37   S155 - S155  2005年05月

    研究発表ペーパー・要旨(国際会議)  

  • Gene Expression Profiling Of Exercise Training-induced Cardiac Hypertrophy

    Motoyuki Iemitsu, Seiji Maeda, Takashi Miyauchi, Mitsuo Matsuda, Hirofumi Tanaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   37   S154 - S154  2005年05月

    研究発表ペーパー・要旨(国際会議)  

  • Exercise-induced Gene Expression Of Angiogenesis-regulated Transcriptional Factors Differs Between Fiber Types In The Skeletal Muscle

    Takeshi Otsuki, Seiji Maeda, Motoyuki Iemitsu, Takashi Miyauchi

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   37   S153 - S153  2005年05月

    研究発表ペーパー・要旨(国際会議)  

  • Gender Differences In Muscle Strength, Blood Flow And Oxygen Consumption Recovery From Intermittent Handgrip Exercise

    Yoko Saito, Motoyuki Iemitsu, Takeshi Otsuki, Seiji Maeda, Ryuichi Ajisaka

    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE   37   S220 - S220  2005年05月

    研究発表ペーパー・要旨(国際会議)  

  • 04-26-ダンス-16 青年期における有酸素性および抵抗性の運動競技継続年数と動脈伸展性および左心室の形態的適応(04 運動生理学,一般研究発表)

    大槻 毅, 前田 清司, 家光 素行, 斉藤 陽子, 谷村 祐子, 鰺坂 隆一, 宮内 卓

    日本体育学会大会予稿集   56 ( 0 )  2005年

    CiNii

  • Chronic exercise training improves aging-induced decrease fatty acid metabolic capacity through peroxisome proliferator-activated receptor (PPAR)-alpha signaling in the heart

    M Iemitsu, S Maeda, Y Irukayama-Tomobe

    CIRCULATION   110 ( 17 ) 828 - 828  2004年10月

    研究発表ペーパー・要旨(国際会議)  

  • 【うっ血性心不全の治療 新世紀への展開】心不全における血管内皮機能

    前田 清司, 酒井 俊, 宮内 卓

    Heart View   5 ( 1 ) 58 - 64  2001年01月

     概要を見る

    心不全患者では,末梢血管収縮反応及び反応性充血や運動による末梢血管拡張反応が低下し,このことが心機能や運動耐容能を悪化させる要因と考えられている.近年になり,血管内皮細胞が様々な血管作動性物質を産生・分泌し,血管の緊張度(トーヌス)や局所の血流調節に重要な役割を果たしていることが明らかにされてきた.血管内皮細胞は,様々な化学刺激や物理刺激によって生理活性物質を産生・放出し,近傍の細胞の緊張や増殖などを調節している.心不全における末梢循環調節異常と血管内皮細胞機能,特に運動耐容能との関連性について概説した

  • 578.陸上運動と水中運動における呼吸・循環応答の比較

    岩崎 直美, 濱田 豊, 白井 克佳, 斎藤 実, 前田 清司, 松田 光生

    体力科學   46 ( 6 ) 901 - 901  1997年12月

    CiNii

  • 131.視覚障害学生の有酸素的作業能と大動脈脈波速度の関係

    柿山 哲治, 柳川 真美, 香田 泰子, 前田 清司, 松田 光生, 池上 晴夫, 高石 昌弘

    体力科學   45 ( 6 ) 670 - 670  1996年12月

    CiNii

  • 345.運動が視覚障害者の免疫機能に及ぼす影響

    香田 泰子, 赤間 高雄, 秋本 崇之, 杉浦 弘一, 龍野 美恵子, 山本 祐里江, 柳川 真美, 天野 和彦, 斎藤 まゆみ, 和久 貴洋, 柿山 哲治, 前田 清司, 松田 光生, 河野 一郎

    体力科學   45 ( 6 ) 777 - 777  1996年12月

    CiNii

▼全件表示

受賞

  • 第10回日本腎臓リハビリテーション学会学術総会YIA副会長賞(共同研究者)

    2020年03月  

  • 大塚スポーツ医・科学賞奨励賞(共同研究者)(日本体力医学会)

    2019年09月  

  • 第9回日本腎臓リハビリテーション学会学術集会YIA副会長賞(共同研究者)

    2019年03月  

  • 第19回日本健康支援学会学術大会優秀賞(共同研究者)

    2018年03月  

  • 第3回日本予防理学療法サテライト集会奨励賞(共同研究者)

    2018年02月  

  • 第25回日本運動生理学会大会学会長賞(共同研究者)

    2017年07月  

  • 第4回日本介護福祉・健康づくり学会若手最優秀賞(共同研究者)

    2016年11月  

  • 大塚スポーツ医・科学賞奨励賞(共同研究者)(日本体力医学会)

    2015年09月  

  • 第28回日本体力医学会奨励賞(日本体力医学会)

    2015年09月  

  • 大塚スポーツ医・科学賞奨励賞(共同研究者)(日本体力医学会)

    2011年09月  

    受賞者: 前田 清司

  • 第13回日本運動生理学会大会若手優秀発表賞(共同研究者)(日本運動生理学会)

    2005年07月   日本運動生理学会  

    受賞者: 前田 清司

  • 第13回日本運動生理学会大会若手優秀発表賞(筆頭演者)(日本運動生理学会)

    2005年07月   日本運動生理学会  

    受賞者: 前田 清司

  • The 8th Asian Federation of Sports Medicine Congress 2005, Best Scientific Research Award, Poster Presentation First Prize (co-author) (Asian Federation of Sports Medicine)

    2005年   Asian Federation of Sports Medicine  

    受賞者: Maeda Seiji

  • The 8th Asian Federation of Sports Medicine Congress 2005, Best Scientific Research Award, Oral Presentation Third Prize (co-author) (Asian Federation of Sports Medicine)

    2005年   Asian Federation of Sports Medicine  

    受賞者: Maeda Seiji

  • Hypertension Research-Novartis(第4回)優秀論文賞(共著者)(日本高血圧学会)

    2004年10月  

    受賞者: 前田 清司

  • American Heart Association Scientific Meeting 2004, Scientific Sessions Poster Competition -Population Science- Award (co-author) (American Heart Association)

    2004年  

    受賞者: 前田 清司

  • 教育研究特別表彰(筑波学都資金財団)

    1998年11月  

    受賞者: 前田 清司

  • 河本体育科学研究奨励賞(筑波大学)

    1994年05月  

    受賞者: 前田 清司

▼全件表示

共同研究・競争的資金等の研究課題

  • 細粒化クルクミンが急性運動後の疲労回復に及ぼす影響に関する研究

    国内共同研究

    研究期間:

    2010年
    -
    2012年
     

  • 加齢や運動習慣が動脈硬化および自律神経機能に与える影響

    国内共同研究

    研究期間:

    2007年
    -
    2009年
     

  • 新しい動脈硬化度評価法の開発に関する研究

    国内共同研究

    研究期間:

    2005年
    -
    2007年
     

  • 動脈伸展性と運動効果の個人差を規定する遺伝的要因

    国内共同研究

    研究期間:

    2002年
    -
    2005年
     

  • 高血圧・動脈硬化を予防するための健康状態の指標化と至適運動プログラムの開発

    国内共同研究

    研究期間:

    2002年
    -
    2005年
     

  • 血圧(大動脈伸展性・末梢循環動態と高血圧)に関する研究

    国内共同研究

    研究期間:

    1999年
    -
    2002年
     

  • 運動時の循環調節メカニズムに関する研究

    国内共同研究

    研究期間:

    2000年
    -
    2001年
     

  • スポーツにおける競技力向上のためのコンディショニングに関する研究

  • 運動による生活習慣病(特に動脈硬化)の予防・改善に関する研究

▼全件表示

講演・口頭発表等

  • 保存期CKD患者における血中FGF21濃度と身体活動量の関連性

    松井, 公宏, 小﨑, 恵生, 小﨑, 奏子, 吉岡, 将輝, 柴田, 愛, 岡, 浩一朗, 斎藤, 知栄, 山縣, 邦弘, 黒尾, 誠, 前田, 清司

    第10回日本腎臓リハビリテーション学会学術集会   (東京) 

    発表年月: 2020年02月

  • 中高齢CKD患者の座位行動と身体活動が筋力に及ぼす影響: Isotemporal Substitutionモデルを用いた検討

    吉岡, 将輝, 小﨑, 恵生, 松井, 公宏, 小﨑, 奏子, 柴田, 愛, 岡, 浩一朗, 黒尾, 誠, 斎藤, 知栄, 山縣, 邦弘, 前田, 清司

    第10回日本腎臓リハビリテーション学会学術集会   (東京) 

    発表年月: 2020年02月

  • 保存期CKD患者における血中Cortisol/DHEAS比と骨格筋量指数の関連性

    森, 貴史, 小崎, 恵生, 松井, 公宏, 黒尾, 誠, 斎藤, 知栄, 山縣, 邦弘, 前田, 清司

    第10回日本腎臓リハビリテーション学会学術集会   (東京) 

    発表年月: 2020年02月

  • 腎保護と心血管疾患予防のための運動:基礎から臨床へ

    前田,清司  [招待有り]

    第10回日本腎臓リハビリテーション学会  

    発表年月: 2020年02月

  • 運動習慣とCKDの重症化

    小崎恵生, 前田清司  [招待有り]

    第10回日本腎臓リハビリテーション学会  

    発表年月: 2020年02月

  • トライアスリートの高強度インターバル・トレーニング(HIIT)に伴うパフォーマンスの経時変化

    生田目颯, 田山寛豪, 前田清司, 大槻毅

    第9回JTUトライアスロン・パラトライアスロン研究会  

    発表年月: 2020年01月

  • Time course of improvement in secretory unbalance of asymmetric dimethylarginine and nitric oxide productions in response to exercise training in middle-aged and older adults

    Fujie, S, Hasegawa, N, Sanada, K, Hamaoka, T, Maeda, S, Iemitsu, M

    ESC Asia with APSC & AFC 2019   (Singapore, SINGAPORE) 

    発表年月: 2019年11月

  • Objectively-assessed sedentary behavior, physical activity, and renal function in middle-aged and older Japanese adults

    Kosaki K, Maeda S

    2019 ASICS SMA Conference  

    発表年月: 2019年10月

  • Aerobic fitness and nephron Index in middle-aged and older adults

    Takahashi K, Maeda S

    2019 ASICS SMA Conference  

    発表年月: 2019年10月

  • 中高齢女性におけるホモシステインと動脈スティフネスおよび遂行機能の関係

    濵崎愛, 赤澤暢彦, 棚橋嵩一郎, 前田清司

    第6回日本予防理学療法学会  

    発表年月: 2019年10月

  • 大学女性アスリートにおける月経中の高強度運動と酸化ストレスとの関連

    田原麗衣, 曽根良太, 松葉開, 渡部厚一, 前田清司, 宮川俊平

    第31回日本臨床スポーツ医学会  

    発表年月: 2019年10月

  • アスリートにおけるトレーニング期間中のマスリン酸摂取が主観的疲労および筋痛度に及ぼす影響

    妙圓園香苗, 白井隆, 川合英介, 隈元翔太, 棚橋嵩一郎, 朴ジヨン, 鈴木啓人, 山内優輝, 前田清司, 高木英樹, 武政徹

    日本体力医学会大会(第74回)   (つくば市)  日本体力医学会  

    発表年月: 2019年09月

  • フルマラソン時の歩調変化と筋損傷、速度低下の関係

    石倉惠介, 時野谷勝幸, 吉田保子, 関根七海, 小﨑恵生, 隈元翔太, 前田清司, 鍋倉, 賢治, 竹越一博

    第74回日本体力医学会大会   (つくば市) 

    発表年月: 2019年09月

  • 専門家主導と比較した住民主導型減量支援プログラムの効果

    水島諒子, 中田, 由夫, 笹井浩行, 左炘雨, 前田清司, 田中喜代次

    第74回日本体力医学会大会   (茨城) 

    発表年月: 2019年09月

  • 若年男性におけるフルマラソンが尿中L-FABPに与える影響

    隈元翔太, 小﨑恵生, 時野谷勝幸, 菅谷健, 石倉惠介, 鍋倉, 賢治, 竹越一博, 前田清司

    第74回日本体力医学会大会   (つくば市) 

    発表年月: 2019年09月

  • フルマラソン前後の尿Cell-free DNA中のミトコンドリアDNA量の変化

    宍倉康浩, 時野谷勝幸, 吉田保子, 関根七海, 菅澤威仁, 石倉惠介, 小﨑恵生, 隈元翔太, 前田清司, 鍋倉, 賢治, 竹越一博

    第74回日本体力医学会大会   (つくば市) 

    発表年月: 2019年09月

  • 減量プログラム参加者における心理的ストレス反応の変化と体重減少との関連

    水島諒子, 中田, 由夫, 笹井浩行, 左炘雨, 前田清司, 黒谷佳代, 瀧本秀美, 田中喜代次

    第66回日本栄養改善学会学術総会   (富山) 

    発表年月: 2019年09月

  • 経口タウリン摂取が高強度レジスタンス運動後の動脈機能へ及ぼす影響~ヒト試験による検証~.<シンポジウム28 運動とタウリン研究の最前線〜その多彩な生理作用に迫る〜>

    羅成圭, 崔英珠, 赤澤暢彦, 大森, 肇, 前田清司

    第74回日本体力医学会大会   (茨城) 

    発表年月: 2019年09月

  • 経口タウリン摂取が高強度レジスタンス運動後の動脈機能へ及ぼす影響 〜ヒト試験による検証〜

    羅成圭, 崔英珠, 赤澤暢彦, 大森肇, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • アスリートにおけるクルクミン摂取が筋損傷および炎症マーカーに及ぼす影響

    崔英珠, 羅成圭, 田名辺陽子, 西嶋尚彦, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 中高齢者における有酸素性運動トレーニング介入時の座位行動が動脈伸展性に与える影響

    瓜兼汐里, 棚橋嵩一郎, 小﨑恵生, 松井公宏, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 中高齢者における血漿CPP値と筋力・筋量との関連性

    岡部直哉, 小崎恵生, 松井公宏, 黒尾誠, 斎藤知栄, 山縣邦弘, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 中高齢CKD患者における身体活動と身体機能の関連性

    吉岡将輝, 小﨑恵生, 松井公宏, 小﨑奏子, 柴田愛, 岡浩一朗, 黒尾誠, 斎藤知栄, 山縣邦弘, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 肥満男性における12週間の食習慣改善または有酸素性運動が糖負荷前後の中心血圧に与える影響

    吉川徹, 熊谷仁, 妙圓園香苗, 膳法亜沙子, 辻本健彦, 田中喜代次, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 薬剤誘導性Dicerノックアウトマウスにおける骨格筋の運動適応

    及川哲志, 李ミンジョン, 本橋紀夫, 前田清司, 赤間高雄, 秋本崇之

    第74回日本体力医学会  

    発表年月: 2019年09月

  • ACTN3 R577X多型は体操競技選手の競技力に関連する

    金子萌子, 熊谷仁, 宮本恵里, 菊池直樹, 神谷宣広, 前田清司, 福典之

    第74回日本体力医学会  

    発表年月: 2019年09月

  • アスリートの競技特性が将来の高血圧発症に及ぼす影響-J-Fit+ study-

    熊谷仁, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 中高齢者における身体機能及びNephron indexの関連

    小﨑奏子, 小﨑恵生, 松井公宏, 吉岡将輝, 黒尾誠, 齋藤 知栄, 山縣邦弘, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 大学生アスリートにおける睡眠と気質の関連

    佐藤智仁, 崔英珠, 栃木悠里子, 濱崎愛, 門馬怜子, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 高齢者におけるレジタンストレーニングと有酸素性 トレーニングの併用が大動脈スティフネスに及ぼす影響

    小崎恵生, 大須賀洋祐, 田中喜代次, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 中高齢女性における血中FGF21濃度と中心血圧および有酸素性体力の関連性

    松井公宏, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 中高齢CKD患者における身体機能と圧受容器反射感受性との関連性

    森翔也, 小崎恵生, 樽味孝, 菅原順, 黒尾誠, 斎藤知栄, 山縣邦弘, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 専門家主導と比較した住民主導型減量支援プログラムの効果

    水島諒子, 前田清司

    第74回日本体力医学会   (茨城) 

    発表年月: 2019年09月

  • 高強度間欠運動を実施するタイミングが高糖質飲料摂取後の血管内皮機能に及ぼす影響

    西谷菜津美, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • フルマラソン時の歩調変化と筋損傷,速度低下の関係

    石倉恵介, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 中高齢者におけるフォームローリングが動脈機能に及ぼす影響

    川谷響, 田川要, 崔英珠, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 細菌感染前の単回運動が与える抗炎症効果―PTX3に着目して―

    膳法亜沙子, 下條信威, 松原朋子, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 肥満者における習慣的なラクトトリペプチド摂取が中心血行動態に及ぼす影響

    棚橋嵩一, 小崎恵生, 松井公宏, 朴ジヨン, 妙圓園香苗, 佐藤智仁, 田川要, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 若年男性における身長が高強度レジスタンストレーニングによる動脈伸展性の変化に及ぼす影響

    田川要, 崔英珠, 羅 成圭, 吉川徹, 熊谷仁, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 老齢マウスの有酸素性トレーニングは動脈血管のadropin分泌の促進を介して血管内皮機能を改善する

    藤江隼平, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 女性アスリートにおける血中エストラジオールが認知機能に及ぼす影響

    栃木悠里子, 濱崎愛, 佐藤智仁, 門馬怜子, 吉岡将輝, 朴ジヨン, 崔英珠, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 体性神経系への刺激入力が起立負荷中の中心及び脳循環制御に与える影響

    福家真理那, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • アスリートにおけるトレーニング期間中のマスリン酸摂取が主観的疲労および筋肉痛度に及ぼす影響

    妙圓園香苗, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 陸上競技女子選手における月経状態および月経周期と睡眠の関係

    門馬怜子, 渡邉友紀子, 棚橋嵩一郎, 栃木悠里子, 濱崎愛, 目崎登, 前田清司

    第74回日本体力医学会  

    発表年月: 2019年09月

  • 若年剣道選手における中心血行動態の適応

    吉岡将輝, 田川要, 佐藤智仁, 門馬怜子, 前田清司

    第52回日本武道学会  

    発表年月: 2019年09月

  • 生体マウスにおけるDicerの欠損は持久性運動による骨格筋適応に影響しない

    及川哲志, 李ミンジョン, 本橋紀夫, 前田清司, 秋本崇之

    第5回日本筋学会  

    発表年月: 2019年08月

  • 運動とテストステロン

    前田清司, 熊谷仁  [招待有り]

    第19回日本Men’s Health医学会  

    発表年月: 2019年07月

  • Arterial stiffness in young male athletes of various sports

    Yoshioka M, Maeda S

    24th Annual Congress of the ECSS  

    発表年月: 2019年07月

  • Influence of incremental short-maximal exercise on urinary liver-type fatty acid-binding protein

    Kumamoto S, Maeda S

    24th Annual Congress of the ECSS  

    発表年月: 2019年07月

  • The relationship between arterial stiffness and increase in blood pressure during exercise in middle-aged overweight and obese men

    Tanahashi K, Maeda S

    24th Annual Congress of the ECSS  

    発表年月: 2019年07月

  • Effect of aerobic exercise on plasma 3-Hydroxyisobutyrate level in overweight and obese men -Comparison between non-Insulin Resistance, pre-Insulin Resistance and Insulin Resistance-

    Myoenzono K, Maeda S

    24th Annual Congress of the ECSS  

    発表年月: 2019年07月

  • 成人男性における有酸素性運動トレーニングはAMSスコアを改善する

    熊谷仁, 妙圓園香苗, 吉川 徹, 前田清司

    第19回日本Men’s Health医学会  

    発表年月: 2019年07月

  • 中高齢者における血中FGF21濃度と身体活動量の関連性

    松井公宏, 小崎恵生, 棚橋嵩一郎, 赤澤暢彦, 大須賀洋祐, 田中喜代次, 黒尾誠, 前田清司

    第19回日本抗加齢医学会  

    発表年月: 2019年06月

  • Changes in arterial adropin levels by age and aerobic training is related to arterial vasodilation

    Fujie S, Hasegawa N, Horii N, Uchida M, Maeda S, Padilla J, Martinez-Lemus LA, Iemitsu M

    American College of Sports Medicine 66th Annual Meeting  

    発表年月: 2019年05月

  • The impact of PMS and PMDD on physical performance in female track and field athletes

    Momma R, Tochigi Y, Hamasaki A, Tanahashi K, Takahashi A, Sato A, Yokota A, Mesaki N, Maeda S

    American College of Sports Medicine 66th Annual Meeting  

    発表年月: 2019年05月

  • Mitochondrial-DNA-m.1382-A>C polymorphism in the MOTS-c is associated with visceral fat area and blood pressure in Japanese men

    Hiroshi Kumagai, Seiji Maeda

    American Aging Association 48th Annual Meeting  

    発表年月: 2019年05月

  • 筋力トレーニングとHMB摂取が閉経後女性の認知機能に及ぼす影響: 12週間の介入試験

    濵崎愛, 棚橋嵩一郎, 若葉京良, 門馬怜子, 横田伍, 佐藤智仁, 田中喜代次, 前田清司

    第5回日本予防理学療法学会サテライト集会  

    発表年月: 2019年05月

  • 一般成人の有酸素性運動能力と腎内血行動態の関連性

    小﨑恵生, 棚橋嵩一郎, 熊谷仁, 大須賀洋祐, 菅谷健, 田中喜代次, 前田清司

    第9回日本腎臓リハビリテーション学会学術集会  

    発表年月: 2019年

  • 中高齢者における身体活動量とNephron Indexの関連

    髙橋奏子, 小﨑恵生, 棚橋嵩一郎, 大須賀洋祐, 田中喜代次, 黒尾誠, 前田清司

    第9回日本腎臓リハビリテーション学会学術集会  

    発表年月: 2019年

  • Do sport descriptions at a young age influence the incidence of hypertension? -J-Fit+ study-

    Kumagai H, Someya Y, Yoshioka M, Miyamoto-Mikami E, Choi Y, Kohmura Y, Suzuki K, Machida S, Naito H, Maeda S, Fuku N

    9th Federation of the Asian and Oceanian Physiological Societies Congress  

    発表年月: 2019年

  • The effect of nanodaimond- and nanoplatinum- coated garmnets (DPV576-D) on physical and psychological stress in baseball player

    Choi Y, Makita M, Nakamura Y, Yamamoto K, Nara T, Kawamura T, Fukuda H, Katano H, Miyakawa S, Maeda S

    ARIHHP Human High Performance International Forum 2019  

    発表年月: 2019年

  • The plasma 3-Hydroxyisobutyrate level is associated with body composition in adult male

    Myoenzono K, Yoshikawa T, Kumagai H, Park J, Miyazaki T, Honda A, Maeda S

    ARIHHP Human High Performance International Forum 2019  

    発表年月: 2019年

  • Effect of single bout of exercise on urinary liver-type fatty acid-binding protein

    Kumamoto S, Kosaki K, Sugaya T, Tanahashi K, Kumagai H, Maeda S

    ARIHHP Human High Performance International Forum 2019  

    発表年月: 2019年

  • Salusin-α is a novel biomarker of cardiovascular disease risk in aging and exercise lifestyle: Cross-Sectional and Intervention Study

    Fujie S, Hasegawa N, Sanada K, Hamaoka T, Maeda S, Padilla J, Martinez-Lemus LA, Iemitsu M

    Epidemiology and Prevention Lifestyle and Cardiometabolic Health 2019 Scientific Sessions  

    発表年月: 2019年

  • A Strategy To Reduce The Dropout Rate In A Volunteer-led Community Weight-loss Program

    Mizushima, Ryoko, Nakata, Yoshio, Zuo, Xinyu, Maeda, Seiji, Tanaka, Kiyoji

    Annual Meeting of the American-College-of-Sports-Medicine (ACSM)   (Minneapolis, MN) 

    発表年月: 2018年05月

  • Effects of taurine supplementation on vascular endothelial function at rest and after resistance exercise.

    Ra, Song-Gyu, Choi, Youngju, Akazawa, Nobuhiko, Kawanaka, Kentaro, Ohmori, Hajime, Maeda, Seiji

    The 21st International Taurine meeting   (Chaina Shenyang and Dalian) 

    発表年月: 2018年05月

  • 身体能力と加齢腎

    小﨑恵生, 前田清司  [招待有り]

    第8回日本腎臓リハビリテーション学会  

    発表年月: 2018年

  • 身体能力と加齢腎

    前田,清司  [招待有り]

    第8回日本腎臓リハビリテーション学会学術集会  

    発表年月: 2018年

  • 運動による予防医療:運動が動脈硬化を予防するメカニズム

    前田,清司  [招待有り]

    第26回日本運動生理学会  

    発表年月: 2018年

  • 運動による降圧機序 –動脈スティフネスの観点から-

    前田,清司  [招待有り]

    第73回日本体力医学会  

    発表年月: 2018年

  • 閉経後女性における身体活動量および運動が血中テストステロン濃度に及ぼす影響

    小松美保, 赤澤暢彦, 棚橋嵩一郎, 小崎恵生, 膳法亜沙子, 熊谷仁, 前田清司

    第18回日本抗加齢医学会総会  

    発表年月: 2018年

  • 中高齢者における有酸素性運動能力が動脈スティフネスおよび副腎ホルモンに及ぼす影響

    赤澤暢彦, 棚橋嵩一郎, 小崎恵生, 熊谷仁, 及川哲志, 濱崎愛, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • アスリートにおける競技特性と動脈スティフネスの関連

    吉岡将輝, 崔英珠, 栃木悠里子, 佐藤智仁, 棚橋嵩一郎, 朴志娟, 門馬玲子, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • アスリートの競技特性と認知機能の関係

    佐藤智仁, 崔英珠, 栃木悠里子, 濱崎愛, 門馬玲子, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 成人男性における握力と動脈スティフネスの関連性

    田川要, 崔英珠, 熊谷仁, 妙圓園香苗, 吉川徹, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 住民主導型減量教室の地域展開:量的・質的手法を用いた支援システムの構築

    水島諒子, 中田由夫, 笹井浩行, 左シンウ, 吉川基, 前田清司, 田中喜代次

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 運動誘発性血管新生におけるマイクロRNA-23クラスターの役割

    及川哲志, 和田正吾, 李ミンジョン, 前田清司, 秋本崇之

    第73回日本体力医学会大会  

    発表年月: 2018年

  • アクアビクスが中高齢者の動脈スティフネスに与える影響

    福家真理那, 菅原順, 山邉貴之, 野村陽介, 橋富達也, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 若年女性におけるエストラジオールが伸張性運動後の筋損傷に及ぼす影響

    高橋あかり, 棚橋嵩一郎, 栃木悠里子, 田川要, 門馬怜子, 目崎登, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 肥満男性における血漿キサンチン酸化還元酵素活性とその関連因子

    横田伍, 小﨑恵生, 中村敬志, 村瀬貴代, 赤利精悟, 吉川徹, 妙圓園香苗, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 若中高齢者における認知機能と骨代謝および血管機能の関係

    濱崎愛, 赤澤暢彦, 吉川徹, 妙圓園香苗, 田川要, 栃木悠里子, 澤野友里子, 中野聡子, 前田清司

    第2回日本呼吸・心血管・糖尿病理学療法学会合同学術大会  

    発表年月: 2018年

  • 日本人における座位行動が動脈スティフネスに与える影響

    棚橋嵩一郎, 竹内彩佳, 西村真琴, 熊谷仁, 膳法亜沙子, 小崎恵生, 赤澤暢彦, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • アルドステロン腎症における自発走運動の腎保護効果

    小﨑恵生, 菅谷健, 大畑敬一, 柴垣有吾, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • アスリートにおける16週間の介入トレーニングは左室スティフネスを改善させる

    野上佳恵, 東本翼, 菅原順, 前田清司, 青沼和隆

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 運動姿勢が若年男性における有酸素性運動時の中心循環動態に及ぼす影響

    山邉貴之, 菅原順, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 若年男性における短時間・低負荷の虚血プレコンディショニングが血管内皮機能に与える影響

    岡部直哉, 崔英珠, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 20年以上のダンス運動が骨密度および動脈硬化度に及ぼす影響

    隈元翔太, 妙圓園香苗, 飯田路佳, 田中喜代次, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 肥満男性における有酸素性運動介入が動脈スティフネスと筋細胞内脂肪•筋細胞外脂肪に及ぼす影響

    朴ジヨン,崔英珠, 妙圓園香苗, 吉川徹, 磯辺智範, 五月女康作, 山海嘉之, 下條信威, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 肥満男性における有酸素性運動が血中3-HIB濃度に及ぼす影響

    妙圓園香苗, 吉川徹, 朴ジヨン, 辻本健彦, 宮崎照雄, 本多彰, 下條信威, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 若年女性アスリートにおける月経不順が脳の実行機能に及ぼす影響 –正常月経アスリートとの比較–

    濱崎愛, 門馬怜子, 栃木悠里子, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 女性アスリートにおける月経随伴症状と運動パフォーマンスの関連

    門馬怜子, 栃木悠里子, 濱崎愛, 棚橋嵩一郎, 高橋あかり, 佐藤智仁, 横田伍, 目崎登, 前田清司

    第73回日本体力医学会大会  

    発表年月: 2018年

  • 中高齢者における運動トレーニングおよびラクトトリペプチドの摂取が認知機能と脳の酸素化動態に及ぼす影響 –8週間の介入試験–

    濵崎愛, 赤澤暢彦, 吉川徹, 妙圓園香苗, 棚橋嵩一郎, 前田清司

    第5回日本理学療法学会学術大会  

    発表年月: 2018年

  • The relationship between the difference of playing styles and the cognitive functions in tennis players

    Tochigi Y, Sugawara Y, Hamasaki A, Sato T, Monma R, Park JY, Tanahashi K, Takahashi A, Maeda S

    23rd Annual Congress of the European College of the European college of Sport Science  

    発表年月: 2018年

  • Effects of endothelin-related gene polymorphisms on age-related arterial stiffening: a 10-year longitudinal study

    Sugawara J, Tomoto T, Noda N, Matsukura, S, Tsukagoshi K, Maeda S

    Experimental Biology 2018  

    発表年月: 2018年

  • High aerobic fitness and muscular strength offset aging-induced lowered male sexual function

    Kumagai H, Yoshikawa T, Myoenzono K, Akazawa N, Maeda S

    The 65th Annual Meeting of the American College of Sports Medicine  

    発表年月: 2018年

  • A strategy to reduce the dropout rate in a volunteer-led community weight-loss program

    Mizushima R, Nakata Y, Zuo X, Maeda S, Tanaka K

    The 65th Annual Meeting of the American College of Sports Medicine  

    発表年月: 2018年

  • Effects of aerobic exercise habit on age-related arterial stiffning: a 10-year lomgitudical study

    Sugawara J, Tomoto T, Noda N, Matsukura, S, Tsukagoshi K, Maeda S

    The 65th Annual Meeting of the American College of Sports Medicine  

    発表年月: 2018年

  • The effect of aquatic exercise on arterial stiffness and central blood pressure

    Fukuie M, Yamabe T, Nomura Y, Hashitomi T, Maeda S, Sugawara J

    The 65th Annual Meeting of the American College of Sports Medicine  

    発表年月: 2018年

  • Long spending time in sedentary behavior is associated with increased arterial stiffness in Japanese older adults

    Tanahashi K, Takeuchi A, Nishimura M, Kumagai H, Zempo-Miyaki A, Kosaki K, Akazawa N, Maeda S

    23rd Annual Congress of the European College of the European college of Sport Science  

    発表年月: 2018年

  • Combined effects of lactotripeptide and aerobic exercise on cognitive function and arterial stiffness in middle-aged and older adults

    Hamasaki A, Akazawa N, Yoshikawa T, Myoenzono K, Tanahashi K, Sawano Y, Nishimura M, Maeda S

    23rd Annual Congress of the European College of the European college of Sport Science  

    発表年月: 2018年

  • Aerobic exercise training reduces plasma 3-hydroxyisobutyrate level in overweight and obese men

    Myoenzono K, Yoshikawa T, Park J, Miyazaki T, Honda A, Shimojo N, Maeda S

    23rd Annual Congress of the European College of the European college of Sport Science  

    発表年月: 2018年

  • Association of plasma 3-hydroxyisobutyrate concentration and physical activity

    Myoenzono K, Yoshikawa T, Kumagai H, Miyazaki T, Honda A, Maeda S

    International Conference on Adaptations and Nutrition in Sports  

    発表年月: 2018年

  • Role of microRNAs in endurance-exercise-induced skeletal muscle adaptation

    Oikawa S, Lee M, Maeda S, Akimoto T

    47th European Muscle Conference  

    発表年月: 2018年

  • Elevation of arterial adropin secretion by aerobic exercise training is related to vasodilation via increase in nitric oxide production in aged mice

    Fujie S, Hasegawa N, Horii N, Uchida M, Maeda S, Iemitsu M

    American Heart Association Scientific Sessions 2018  

    発表年月: 2018年

  • 住民主導による健康減量教室の質的分析による課題抽出

    Maeda,Seiji

    第18回日本健康支援学会年次学術大会  

    発表年月: 2017年03月

  • 座位行動に対する即時フィードバックの探索的有効性 -研究デザイン-

    Maeda,Seiji

    第18回日本健康支援学会年次学術大会  

    発表年月: 2017年03月

  • The effect of resistance training on central arterial compliance and angiotensin II in young men

    Maeda,Seiji

    ARIHHP Human High Performance International Forum 2017  

    発表年月: 2017年03月

  • 急性運動による腎血流量の減少とその機序

    Maeda,Seiji  [招待有り]

    第7回日本腎臓リハビリテーション学会  

    発表年月: 2017年02月

  • 定期的な運動が中高齢者の腎臓に及ぼす影響 –腎内血行動態に着目して-

    Maeda,Seiji  [招待有り]

    第7回日本腎臓リハビリテーション学会  

    発表年月: 2017年02月

  • 中高齢者における握力と腎内血管抵抗指数(RRI)の関連性

    Maeda,Seiji

    第7回日本腎臓リハビリテーション学会  

    発表年月: 2017年02月

  • 運動誘発性疲労マーカーとしての唾液中タウリンの可能性

    Maeda,Seiji

    第3回国際タウリン研究会日本部会  

    発表年月: 2017年02月

  • 健康に過ごすための運動による動脈硬化予防

    Maeda,Seiji  [招待有り]

    第5回NSCA国際カンファレンス  

    発表年月: 2017年01月

  • 中高齢者における有酸素性運動能力が脳血流拍動性に及ぼす影響

    Maeda,Seiji

    第5回NSCA国際カンファレンス  

    発表年月: 2017年01月

  • Regular exercise and arterial stiffness

    Maeda,Seiji  [招待有り]

    The 7th Asia Conference on Kinesiology  

    発表年月: 2016年11月

  • 成人男性における運動能力と勃起機能の関連

    Maeda,Seiji

    第4回日本介護福祉・健康づくり学会  

    発表年月: 2016年11月

  • 閉経が食習慣改善による内臓脂肪面積の低下に及ぼす影響

    Maeda,Seiji

    第4回日本介護福祉・健康づくり学会  

    発表年月: 2016年11月

  • Habitual aerobic exercise increases serum testosterone levels in overweight and obese men

    Maeda,Seiji

    American Physiological Society-Integrative Biology of Exercise VII  

    発表年月: 2016年11月

  • アスリートにおける睡眠時のリカバリーウェア着用がコンディションに及ぼす影響 —高強度トレーニング期間中における検討—

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 減量にともなう筋量の変化に睡眠質が及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 成人肥満男性における12週間の定期的な有酸素性運動がエストラジオール/テストステロン比に及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 肥満男性における有酸素性運動と食習慣改善が血中テストステロン濃度に及ぼす影響 —有酸素性運動と食習慣改善の比較—

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 剣道選手における強化合宿中の睡眠質が唾液中分泌型免疫グロブリンAに及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 高反発マットレスが寝姿勢時の体圧分布に及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 中高齢者における有酸素性運動トレーニングが実行機能に及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 有酸素性トレーニングが一過性の有酸素性運動後の脳血流拍動性に及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 上肢および下肢の局所温熱がバドミントンパフォーマンスに及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 肥満男性における定期的な有酸素性運動が免疫機能に及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 行動変容技法を用いた低頻度の運動教室が身体活動量に及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 持久性鍛錬者における下肢陰圧負荷解放が中心および脳循環に及ぼす影響

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 肥満男性における有酸素性運動トレーニングが血漿アミノ酸濃度に及ぼす影響 ~網羅的解析による検討~

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 閉経後女性における骨代謝とAIの関連性 -運動トレーニングの影響-

    Maeda,Seiji

    第71回日本体力医学会大会  

    発表年月: 2016年09月

  • 運動療法による動脈硬化の改善

    Maeda,Seiji  [招待有り]

    第35回日本臨床運動療法学会学術集会  

    発表年月: 2016年09月

  • 運動とクルクミンによる抗動脈硬化作用

    Maeda,Seiji  [招待有り]

    第63回日本食品科学工学会  

    発表年月: 2016年08月

  • 集団型減量支援プログラムにおける減量効果と社会的支援の関係

    Maeda,Seiji

    第64回日本教育医学会大会  

    発表年月: 2016年08月

  • 定期的な有酸素性運動が血中テストステロン濃度に及ぼす影響:肥満男性と非肥満男性における検討

    Maeda,Seiji

    第24回日本運動生理学会  

    発表年月: 2016年07月

  • 剣道選手における唾液中分泌型免疫グロブリンAが認知機能に及ぼす影響

    Maeda,Seiji

    第24回日本運動生理学会  

    発表年月: 2016年07月

  • 高吸収クルクミンによる「抗動脈硬化」作用および「抗筋疲労」効果

    Maeda,Seiji  [招待有り]

    第16回日本抗加齢医学会総会  

    発表年月: 2016年06月

  • Aerobic exercise training improves response of central blood pressure to oral glucose loading in overweight/obese men

    Maeda,Seiji

    20th Annual Congress of the European College of Sport Science (ECSS)  

    発表年月: 2016年06月

  • Aerobic exercise training changes in brachial artery shear patterns in middle aged and older adults

    Maeda,Seiji

    20th Annual Congress of the European College of Sport Science (ECSS)  

    発表年月: 2016年06月

  • Body height affects increase in arterial stiffness following acute resistance exercise

    Maeda,Seiji

    20th Annual Congress of the European College of Sport Science (ECSS)  

    発表年月: 2016年06月

  • The effect of aerobic exercise training on plasma amino acids concentrations in overweight and obese men

    Maeda,Seiji

    20th Annual Congress of the European College of Sport Science (ECSS)  

    発表年月: 2016年06月

  • 有酸素性運動能力に対する近位大動脈スティフネスの影響

    Maeda,Seiji

    第16回臨床血圧脈波研究会  

    発表年月: 2016年06月

  • Aerobic exercise training increases testosterone production in the testis in OLETF rat

    Maeda,Seiji

    Experimental Biology 2016  

    発表年月: 2016年04月

  • The effect of left ventricular-central artery coupling on cerebrovascular hemodynamics: insights from lower body negative pressure

    Maeda,Seiji

    Experimental Biology 2016  

    発表年月: 2016年04月

  • 肥満男性における生活習慣改善が血漿アミノ酸濃度に及ぼす影響

    Maeda,Seiji

    第166回日本体力医学会関東地方会  

    発表年月: 2016年03月

  • 中高齢者における定期的な運動がもたらす腎保護作用 ‐尿中L型脂肪酸結合蛋白に着目して‐

    Maeda,Seiji

    第6回日本腎臓リハビリテーション学会  

    発表年月: 2016年03月

  • タウリン摂取が一過性伸張性運動後の非運動肢血管内皮機能に及ぼす影響

    Maeda,Seiji

    第2回国際タウリン研究会日本部会  

    発表年月: 2016年03月

  • 地域在住高齢者における身体活動量の日間変動と動脈硬化指標との関連

    Maeda,Seiji

    第17回日本健康支援学会年次学術大会  

    発表年月: 2016年02月

  • タウリン摂取は伸張性レジスタンス運動後の遅発性筋肉痛と動脈スティフネスの増加を抑制する

    前田,清司

    第1回国際タウリン研究会日本部会  

    発表年月: 2015年02月

  • 月経の有無が骨格筋および腱の硬度に与える影響 〜デジタル超音波診断装置による検討〜

    Maeda,Seiji

    第25回日本臨床スポーツ医学会学術集会  

    発表年月: 2014年11月

  • 運動とクルクミン —動脈硬化と筋疲労に対する効果—

    前田,清司  [招待有り]

    食品開発展2014  

    発表年月: 2014年10月

  • 肥満男性における生活習慣改善が脈圧増幅に与える影響

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • タウリン摂取は伸張性運動後の動脈スティフネスと酸化ストレスの増加を抑制する

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • 短期間の高強度持久性トレーニングが中心動脈伸展性および心機能に及ぼす影響

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • 下肢温熱刺激が中高齢女性の動脈スティフネスに及ぼす影響

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • 中高齢者における中心血圧と体幹の柔軟性の関連

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • 剣道選手における強化合宿中のクルクミン摂取が分泌型免疫グロブリンAと心理的コンディションに及ぼす影響

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • ジュニアアスリートにおける睡眠が新しい運動技能の獲得に及ぼす影響

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • 有酸素性持久力が安静時頸動脈シェアレイトに与える影響

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • 生活習慣改善が肥満男性のテストステロンに及ぼす影響:食習慣 vs 運動

    Maeda,Seiji

    第69回日本体力医学会大会  

    発表年月: 2014年09月

  • 運動と動脈硬化度

    前田,清司  [招待有り]

    日本体育学会第65回大会  

    発表年月: 2014年08月

  • Taurine supplementation attenuates increase in arterial stiffness following high intense eccentric exercise

    Maeda,Seiji

    19th Annual Congress of the European College of Sport Science (ECSS)  

    発表年月: 2014年07月

  • 運動誘発性の動脈スティフネス増加に対する抗酸化サプリメント摂取の効果

    Maeda,Seiji

    2014年運動と循環研究会  

    発表年月: 2014年07月

  • 30ヶ月間の体重変化が動脈スティフネスに及ぼす影響:集団型減量支援の効果を検証したランダム化比較試験

    Maeda,Seiji

    第22回日本運動生理学会大会  

    発表年月: 2014年07月

  • 生活習慣改善が肥満男性の中心脈圧に与える影響

    Maeda,Seiji

    第22回日本運動生理学会大会  

    発表年月: 2014年07月

  • 運動誘発性疲労に伴い唾液中タウリン濃度は増加する

    Maeda,Seiji

    第22回日本運動生理学会大会  

    発表年月: 2014年07月

  • 一過性の有酸素性運動が中心血圧に及ぼす影響

    Maeda,Seiji

    第22回日本運動生理学会大会  

    発表年月: 2014年07月

  • スポーツ医学分野でのクルクミンのアンチエイジング:運動とクルクミンによる抗動脈硬化作用

    前田,清司  [招待有り]

    第14回日本抗加齢医学会総会  

    発表年月: 2014年06月

  • Aerobic exercise training decreases aortic pulse pressure and augmentation pressure after acute aerobic exercise in middle-aged and older women

    Maeda,Seiji

    The Pulse of Asia 2014  

    発表年月: 2014年06月

  • Effects of acute warm footbath on central arterial blood pressure in young men

    Maeda,Seiji

    The Pulse of Asia 2014  

    発表年月: 2014年06月

  • Effect of lifestyle modification on serum testosterone level and central blood pressure in obese men

    Maeda,Seiji

    The Pulse of Asia 2014  

    発表年月: 2014年06月

  • 若年男性における足湯が動脈スティフネスに及ぼす影響:大動脈スティフネスと下肢動脈スティフネスの検討

    Maeda,Seiji

    第14回臨床血圧脈波研究会  

    発表年月: 2014年06月

  • 持久系アスリートにおける短期間の高強度持久性トレーニングが中心動脈伸展性に及ぼす影響

    Maeda,Seiji

    第14回臨床血圧脈波研究会  

    発表年月: 2014年06月

  • 運動とクルクミン —動脈硬化と筋疲労に対する効果—

    前田,清司  [招待有り]

    第19回国際食品素材/添加物展・会議  

    発表年月: 2014年05月

  • Accelerated age-related increases in arterial stiffness in US vs. Japanese women

    前田,清司

    World Congress of Cardiology Scientific Sessions 2014  

    発表年月: 2014年05月

  • Influence of central artery compliance on carotid artery blood flow profile

    前田,清司

    World Congress of Cardiology Scientific Sessions 2014  

    発表年月: 2014年05月

  • Taurine supplementation decreases delayed onset muscle soreness but not muscle damage induced by high intense eccentric exercise

    Maeda,Seiji

    19th International Taurine Meeting  

    発表年月: 2014年05月

  • Effects of short-term vigorous endurance training on central arterial stiffness in endurance athletes

    Maeda,Seiji

    The 61th Annual Meeting of the American College of Sports Medicine  

    発表年月: 2014年05月

  • Acute aerobic exercise increases serum estradiol concentrations in young healthy men

    Maeda,Seiji

    The 61th Annual Meeting of the American College of Sports Medicine  

    発表年月: 2014年05月

  • Acute Aerobic Exercise Increases Serum Estradiol Concentrations In Young Healthy Men

    Oikawa, Satoshi, Tochigi, Yuriko, Akazawa, Nobuhiko, Tanahashi, Koichiro, Maeda, Seiji

    61st Annual Meeting of the American-College-of-Sports-Medicine   (Atlanta, GA) 

    発表年月: 2014年04月

  • クロレラ由来の総合栄養サプリメントによる動脈スティフネスの改善と血漿NOx濃度

    前田,清司

    第13回臨床血圧脈波研究会  

    発表年月: 2013年06月

  • 肥満男性における12週間の生活習慣改善が血中テストステロン濃度に及ぼす影響

    前田,清司

    第157回日本体力医学会関東地方会  

    発表年月: 2013年03月

  • サプリメントによる抗動脈硬化作用の増強

    前田,清司  [招待有り]

    第3回透析運動療法研究会  

    発表年月: 2013年02月

  • 生活習慣と血管老化 —クルクミンの可能性を探る—

    前田,清司  [招待有り]

    第2回クルクミンサイエンスカフェ  

    発表年月: 2012年12月

  • 生活習慣病の統合的な予防メカニズム

    前田,清司  [招待有り]

    NSCAジャパンストレングス&コンディショニングカンファレンス2012  

    発表年月: 2012年12月

  • 肥満男性における食習慣改善が動脈伸展性と血中PTX3濃度に及ぼす影響

    前田,清司

    第67回日本体力医学会大会  

    発表年月: 2012年09月

  • 伸張性運動が動脈スティフネスと脳血流動態に及ぼす影響

    前田,清司

    第67回日本体力医学会大会  

    発表年月: 2012年09月

  • 一過性の高強度筋力運動が血管内皮機能に及ぼす影響 ―血流依存性血管拡張および血流低下由来の血管収縮の応答―

    前田,清司

    第67回日本体力医学会大会  

    発表年月: 2012年09月

  • 肥満男性における12週間の有酸素性運動と食事改善の併用が中心血圧に及ぼす影響

    前田,清司

    第67回日本体力医学会大会  

    発表年月: 2012年09月

  • バドミントン競技選手における血管内皮機能および反射性循環調節に関する研究 ―利き腕と非利き腕に着目して―

    前田,清司

    第67回日本体力医学会大会  

    発表年月: 2012年09月

  • メタボローム解析によるアスリートの唾液中疲労マーカーの網羅的探索

    前田,清司

    第67回日本体力医学会大会  

    発表年月: 2012年09月

  • 閉経後中高齢女性における有酸素性トレーニングが脳血流動態に及ぼす影響

    前田,清司

    2012年脳・神経・内分泌系から運動の意義を考える会  

    発表年月: 2012年09月

  • Effects of acute high-intensity resistance exercise on arterial compliance and vascular endothelial function

    Maeda,Seiji

    2012 Commemorating the 88 Seoul Olympic Games International Sport Science Congress  

    発表年月: 2012年08月

  • The effect of 38°C water exercise on arterial stiffness in elderly subjects

    Maeda,Seiji

    17th Annual Congress of the European College of Sport Science (ECSS)  

    発表年月: 2012年07月

  • 運動習慣と動脈硬化

    前田,清司  [招待有り]

    第37回日本運動療法学会  

    発表年月: 2012年06月

  • Inhibition of Angiotensin II and Recruitment of Endothelial Progenitor Cells by Lactotripeptide Administration Ameliorates Vascular Endothelial Cell Function in Elderly Women

    Shimojo,Nobutake, Maruyama,Hidekazu, Yoshizawa,Mutsuko, Niwayama,Jun, Miyahara,Takaaki, Misono,Maiko, Miyaki,Asako, Tajiri,Kazuko, Miyauchi,Takashi, Maeda,Seiji

    81st Annual Scientific Session of the American-Heart-Association  

    発表年月: 2008年11月

  • Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy: Involvement of hyopoxia inducible factor

    Hoshino, K, Kawabuchi, I

    80th Annual Scientific Session of the American-Heart-Association  

    発表年月: 2007年11月

  • Exercise training prevents aging-induced cardiomyocyte loss via apoptotic signaling activation in the heart

    Lemitsu, Motoyuki, Maeda, Seiji, Miyachi, Motohiko, Miyauchi, Takashi

    80th Annual Scientific Session of the American-Heart-Association  

    発表年月: 2007年11月

  • Prognostic simple test of short memory and physical function in aged 80 and older outpatients

    Shini,Nobutake, Jesmin,Subrina, Soma,Masaaki, Maeda,Seiji, Miyauchi,Takashi, Aonuma,Kazutaka

    80th Annual Scientific Session of the American-Heart-Association  

    発表年月: 2007年11月

  • Cardioprotective effect of eicosapentaenoic acid, an important fish oil, through suppression of endothelin-1-induced cardiomyocyte hypertrophy via PPAR-alpha

    Shimojo N, Jesmin,Subrina, Soma,Masaaki, Maeda,Seiji, Miyauchi,Takashi, Aonuma,Kazutaka

    80th Annual Scientific Session of the American-Heart-Association   (USA Orlando) 

    発表年月: 2007年11月

  • Effects of vibrotactile feedback on sedentary behaviors in sedentary adults: A pilot randomized controlled trial

    Maeda,Seiji

    22th Annual Congress of the European College of Sport Science  

  • Effect of bright light exposure before sleep on urinary metabolities in humans

    Maeda,Seiji

    22th Annual Congress of the European College of Sport Science  

  • Vigorous-intensity physical activity may improve central aortic pressure response to glucose loading in overweight/obese men

    Maeda,Seiji

    The 64th Annual Meeting of the American College of Sports Medicine  

  • Effects of lifestyle modifications on serum testosterone levels in obese men

    Maeda,Seiji

    The 64th Annual Meeting of the American College of Sports Medicine  

  • Effect of estradiol/progesterone ratio on cognitive function at rest and during exercise in healthy young women

    Maeda,Seiji

    22th Annual Congress of the European College of Sport Science  

  • The effects of bright light exposure at night on circadian rhythms and energy metabolism

    Maeda,Seiji

    World Sleep 2017  

  • Curcumin intake after eccentric exercise effectively reduces muscle damage and enables faster recovery

    Maeda,Seiji

    International Sport Exercise Nutrition Conference 2017  

  • The effect of aerobic exercise training of plasma 3-Hydroxyisobutyrate concentration in overweight and obese men

    Maeda,Seiji

    ARIHHP Human High Performance International Forum 2018  

  • Light exposure at night disrupts circadian rhythms and energy metabolism

    Maeda,Seiji

    ARIHHP Human High Performance International Forum 2018  

  • Association of plasma 3-Hydroxyisobutyrate concentration and physical activity in men

    Maeda,Seiji

    ARIHHP Human High Performance International Forum 2018  

  • Aging, regular aerobic exercise, and conduit artery hemodynamic profile

    Maeda,Seiji

    ARIHHP Human High Performance International Forum 2018  

  • Effects of combined on-land and in-water aerobic exercise training on arterial stiffness: central and peripheral arterial function in triathletes of the national team for university students

    Maeda,Seiji

    ARIHHP Human High Performance International Forum 2018  

  • Time course of changes in nitric oxide-regulated hormones by aerobic exercise training in middle-aged and older adults

    Maeda,Seiji

    ARIHHP Human High Performance International Forum 2018  

  • 定期的な運動と動脈硬化度

    前田,清司  [招待有り]

    第17回日本抗加齢医学会総会  

  • 持久力および筋力は成人男性における男性機能に関連する

    前田,清司

    第25回日本運動生理学会大会  

  • 中高齢者における有酸素性運動介入が脳血流動態および認知機能に与える影響

    前田,清司

    第24回脳機能とリハビリテーション研究会学術集会  

  • Contribution of polymorphism in endothelin-related genes and regular physical activity on individual difference in age-related arterial stiffening: a 10-year longitudinal study

    Maeda,Seiji

    第72回日本体力医学会大会  

  • 若・中年男性における男性機能と骨格筋率および体脂肪率の関連

    前田,清司

    第72回日本体力医学会大会  

  • 運動による骨格筋適応におけるマイクロRNAの関与

    前田,清司

    第72回日本体力医学会大会  

  • 若年女性における一過性の伸張性運動が動脈スティフネスに与える影響

    前田,清司

    第72回日本体力医学会大会  

  • 10年間の追跡研究に基づく動脈硬化の加齢変化の個人差の機序:エンドセリンA/B受容体遺伝子多型および身体活動の関与

    前田,清司

    第72回日本体力医学会大会  

  • 若年男性におけるレジスタンストレーニングが動脈伸展性および血清トロンボキサン濃度に及ぼす影響とその関係性

    前田,清司

    第72回日本体力医学会大会  

  • 肥満男性の食習慣改善による血中BCAA濃度および体組成指標の変化の関連

    前田,清司

    第72回日本体力医学会大会  

  • 陸上競技女子長距離選手における貧血状態と血中アミノ酸濃度の関連

    前田,清司

    第72回日本体力医学会大会  

  • 男性機能の低下は中心動脈スティフネスの増大と関連する

    前田,清司

    第5回日本介護福祉・健康づくり学会大会  

  • Effects of taurine supplementation on vascular endothelial function at rest and after resistance exercise

    前田,清司

    第4回国際タウリン研究会日本部会  

  • 行動変容理論を活用した低頻度開催型運動プログラムの長期的効果

    前田,清司

    第19回日本健康支援学会年次学術大会  

  • 男子サッカー選手における血管内皮機能が高温環境下運動時の皮膚血流および体温に及ぼす影響

    前田,清司

    第72回日本体力医学会大会  

  • 中高齢者における睡眠時間が有酸素性運動介入による動脈伸展性および最高酸素摂取量の向上に及ぼす影響

    前田,清司

    第72回日本体力医学会大会  

  • 中高齢女性の血漿キサンチン酸化還元酵素活性とその関連因子

    前田,清司

    第72回日本体力医学会大会  

  • 高強度運動によるウォームアップがジャンプ能力と無酸素性パワーに及ぼす影響

    前田,清司

    第72回日本体力医学会大会  

  • 筋損傷軽減のために最適なクルクミン摂取のタイミングとは?

    前田,清司

    第72回日本体力医学会大会  

  • 中高齢者の認知機能および脳酸素化動態の加齢変化

    前田,清司

    第3回日本予防理学療法サテライト集会  

  • Sedentary Behavior, Physical Activity And Bone Mineral Density In Ckd Patients: An Isotemporal Substitution Approach

    Yoshioka, Masaki, Kosaki, Keisei, Matsui, Masahiro, Takahashi, Kanako, Shibata, Ai, Oka, Koichiro, Kuro-o, Makoto, Saito, Chie, Yamagata, Kunihiro, Maeda, Seiji

    American-College-of-Sports-Medicine (ACSM) Virtual Conference   (ELECTR NETWORK) 

  • Sedentary Behavior, Physical Activity, And Baroreflex Sensitivity In Middle-aged And Older Adults

    Mori, Shoya, Kosaki, Keisei, Matsui, Masahiro, Takahashi, Kanako, Yoshioka, Masaki, Tarumi, Takashi, Sugawara, Jun, Shibata, Ai, Oka, Koichiro, Kuro-o, Makoto, Saito, Chie, Yamagata, Kunihiro, Maeda, Seiji

    American-College-of-Sports-Medicine (ACSM) Virtual Conference   (ELECTR NETWORK) 

  • 指尖容積脈波による血管年齢測定の妥当性検証:一過性メンタルストレスと日間変動の影響

    山邉貴之, 樽味孝, 菅原順, 前田清司

    第74回日本体力医学会  

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