Updated on 2024/12/21

写真a

 
MACHIDA, Kazuhiko
 
Affiliation
Faculty of Human Sciences
Job title
Professor Emeritus
Degree
Master of Health Sciences ( University of Tokyou )
Doctor of Health Sciences ( Yniversity of Tokyo )
Homepage URL
http://www.kitanet.ne.jp/~m67235

Research Experience

  • 1988
    -
    Now

    Waseda University   School of Human Sciences

  • 1988
    -
    　

    - Waseda University ,Professor

  • 1987
    -
    1988

    ニューヨーク医科大学 客員教授

  • 1987
    -
    1988

    New York Medical College, Visiting Professor

  • 1980
    -
    1988

    大分医科大学医学部・大学院医学研究科博士課程 助教授

  • 1980
    -
    1988

    Medical College of Oita, Associate Professor

  • 1976
    -
    1980

    国立公害研究所環境保健部 研究員・主任研究員

  • 1976
    -
    1980

    National Institute for environmental Sciences Researcher, Chief Researcher

  • 1968
    -
    1976

    Juntendo University   Faculty of Medicine

  • 1968
    -
    1976

    Juntendo University, Research Assistant, Instructor

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Education Background

  • 　
    -
    1976

    The University of Tokyo  

  • 　
    -
    1976

    University of Tokyo   Graduate School, Division of Medical Sciences   Epidemiology  

  • 　
    -
    1973

    The University of Tokyo  

  • 　
    -
    1973

    University of Tokyo   Graduate School, Division of Medical Sciences   Epidemiology  

  • 　
    -
    1968

    Waseda University   School of Education  

  • 　
    -
    1968

    Waseda University   Faculty of Education   Biological Siences  

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Committee Memberships

  • 1994
    -
    2008

    日本疫学会  評議員

  • 1997
    -
    2005

    日本レーザースポーツ医学会  評議員

  • 2001
    -
    　

    日本予防医学リスクマネージメント学会  理事

  • 1997
    -
    　

    体力・栄養免疫学会  監事（１９９７－２００９）、会長（２００９－現在）

  • 1991
    -
    　

    日本民族衛生学会  評議員

  • 1990
    -
    　

    日本生気象学会  評議員

  • 1990
    -
    　

    日本体力医学会  評議員

  • 1983
    -
    　

    日本衛生学会  評議員

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Professional Memberships

  • 　
    　
    　

    日本レーザースポーツ医学会

  • 　
    　
    　

    体力・栄養免疫学会

  • 　
    　
    　

    日本疫学会

  • 　
    　
    　

    日本民族衛生学会

  • 　
    　
    　

    日本産業ストレス学会

  • 　
    　
    　

    日本予防医学リスクマネージメント学会

  • 　
    　
    　

    日本微量元素学会

  • 　
    　
    　

    日本生気象学会

  • 　
    　
    　

    日本栄養食糧学会

  • 　
    　
    　

    日本産業衛生学会

  • 　
    　
    　

    日本体力医学会

  • 　
    　
    　

    日本公衆衛生学会

  • 　
    　
    　

    日本衛生学会

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Research Areas

  • Hygiene and public health (non-laboratory) / Hygiene and public health (laboratory) / Medical management and medical sociology

Research Interests

  • 感染症

  • 公衆衛生学

  • 健康福祉医療政策

  • 予防医学

  • infectious deisease

  • Public Health

  • Welfare and medical Policy

  • health

  • Preventive Medicine

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Awards

  • 第1回体力・栄養・免疫学会賞

    2001  

 

Books and Other Publications

  • すぐわかる、よくわかる！ 任意後見 サポートキット

    文芸社  2012 ISBN: 9784286115061

  • 21世紀の予防医学・公衆衛生 第2版（大幅な改定）

    杏林書院  2012

  • 新簡明衛生公衆衛生

    南山堂  2010 ISBN: 9784525180560

  • 感染症ワールド 第３版

    早稲田大学  2010 ISBN: 9784657102140

  • ２１世紀の予防医学・公衆衛生

    杏林書院  2008 ISBN: 9784764400641

  • 現代人間科学講座第3巻 「健康福祉」人間科学

    朝倉書店  2008

  • 生命・医療・福祉ハンドブック

    コロナ社(東京)  2007

  • 感染症ワールド 第2版

    早稲田大学出版部  2007 ISBN: 9784657076182

  • 感染症を予防する

    健康アイランド（大同マネイジメントサービス）  2006

  • 感染症ワールド[免疫力・健康・環境]

    早稲田大学出版部  2005

  • 医学大辞典（伊藤正雄、井村裕夫、高久史麿総編集）

    医学書院  2003

  • 長寿科学辞典（祖父江逸朗監修）

    医学書院（東京）  2003

  • 医学生物学大辞典（和田攻総監修）

    朝倉書店  2002

  • 看護学大事典（総編集：和田攻、南裕子、小峰光博）

    医学書院  2002

  • 疫学概論-理論と方法-

    朝倉書店  2000

  • 疫学概論 ―理論と方法―

    朝倉書店  2000

  • 忍び寄る感染症 二十一世紀の人々に待っているものは

    早稲田大学出版部  1999

  • 長寿科学エンサイクロペディア

    長寿科学振興財団  1997

  • 主要元素と健康

    南山道  1996

  • 新簡明衛生公衆衛生

    南山堂  1994

  • 生気象学の事典

    朝倉書店  1992

  • 公衆栄養学

    朝倉書店  1987

  • 簡明衛生公衆衛生

    南山道  1985

  • 環境中の微量金属の測定－試料の前処理法

    東京化学同人  1985

  • Trace analysis and Technological development

    Wiley Easton Limited  1983

  • Trace analysis and Technological development

    Wiley Easton Limited  1983

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Research Projects

  • 飲料水の健康に及ぼす影響に関する研究

    Project Year :

    1991
    -
    2002
     

  • Effect of drinking water on health

    Project Year :

    1991
    -
    2002
     

  • 健康福祉医療対策

    保健医療分野における基礎研究推進事業

    Project Year :

    1996
    -
    　
     

  • 健康福祉医療政策

    保健医療分野における基礎研究推進事業

    Project Year :

    1996
    -
    　
     

  • Health/welfare/medical Policy

    Basic Research Promotion Service for Health and Medical Field

    Project Year :

    1996
    -
    　
     

  • 高齢者の健康に及ぼすライフスタイルに関する血清疫学的研究

    Project Year :

    1994
    -
    　
     

  • Sero-epidemiological study for the effects of life style on their health in the aged Peresons

    Project Year :

    1994
    -
    　
     

  • 生体防御機能に及ぼす適度な運動習慣とストレスの影響に関する研究

    Project Year :

    1990
    -
    　
     

  • Effects of moderate exercise and stress on the host defference system

    Project Year :

    1990
    -
    　
     

  • 大学時代の運動と中年期の健康とライフスタイル（アンケート調査）

  • 高齢化社会に於ける健康福祉医療政策：特にライフスタイル・自立と医療行動・医療費

  • 高齢者のライフスタイルと健康(健康管理・血清疫学調査）

  • ライフスタイル（適度な運動習慣、ストレス、食生活・嗜好品）と非特異免疫能を中心とした生体防御機能（動物実験）

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Misc

  • Effects of psychological stress on neutrophil phagocytosis and bactericidal activity in humans - a meta-analysis

    Kazumasa Tsukamoto, Kazuhiko Machida

    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY   91 ( 2 ) 67 - 72  2014.02

    Book review, literature introduction, etc.  

    　View Summary

    Several authors have reviewed the effects of psychological stress on lymphocyte activity. However the effect of psychological stress on neutrophil functions has not been reviewed. The present meta-analysis summarizes evidence of the effects of psychological stress on neutrophil phagocytosis and bactericidal activity collated from a MEDLINE search of the English literature. We searched the database to identify the relevant studies through April 30, 2013. Eleven studies met our inclusion criteria and we divided them into those addressing transient acute stress (3 studies, n = 74), academic examinations (4 studies n = 101) and chronic stress/life events (4 studies, n = 193). We performed a meta-analysis of the data and calculated total standardized mean differences (SMD) to evaluate the effects of chronic stress. Transient acute stressors might both enhance and decrease these neutrophil functions. Academic examinations tended to elevate neutrophil functions. On the other hand, the total SMDs of neutrophil phagocytosis and bactericidal activity altered by chronic stress/life events were -0.589 (95% CI: -0.908 to -0.270, p < 0.05) and -0.547 (95% CI: -0.845 to -0.248, p < 0.05), respectively, indicating suppressive effects on these neutrophil functions. Further systematic review of more pooled studies is warranted to confirm that academic examinations might enhance, whereas chronic stress/life events might suppress these neutrophil functions. (C) 2013 Elsevier B.V. All rights reserved.

    DOI

  • Flu Vacctination acceptance among children and awareｎeｓｓ of mothers in Japan

    Yoko Tsuchiya, Naoki Shida, Kazuhiko Machida

    Ｐｒｏｃｅｄｉａ ｏｎ Ｖａｃｃｉｎｏｌｏｇｙ   8   12 - 17  2014

  • Flu Vacctination acceptance among children and awareｎeｓｓ of mothers in Japan

    Yoko Tsuchiya, Naoki Shida, Kazuhiko Machida

    Ｐｒｏｃｅｄｉａ ｏｎ Ｖａｃｃｉｎｏｌｏｇｙ   8   12 - 17  2014

  • Psychophysiological Effects of Hand Massage in Geriatric Facility Residents

    OGAWA Namiko, KURODA Kumiko, OGAWARA Satoshi, MIYAKE Naoyuki, MACHIDA Kazuhiko

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)   69 ( 1 ) 24 - 30  2014

    　View Summary

    Objectives: Geriatric facility residents experience easy decrease of their quality of life (QOL) compared with elderly people cared for in their own homes owing to environmental changes. Because complementary and alternative medicine is useful to improve QOL, a simple manual for hand massage for inexperienced volunteers was developed, and the physical and psychological effects of this method were examined.<br> Methods: Thirty-six female geriatric facility residents (mean age, 84.5 years) were chosen. They were divided into two groups: the control and hand-massaged groups. In the hand-massaged group, females received 15 min hand massage from volunteers in accordance with a simple manual. No hand massage was performed in the control group. Before and after the treatment, a survey using a questionnaire (7 items; e.g., tension, fatigue) and physiological measurements (e.g., blood pressure, hand skin temperature), and measurement of cortisol and chromogranin A levels in saliva samples using enzyme-linked immunosorbent assay kits were carried out. Data were analyzed by two-way analysis of variance (ANOVA) to determine the effects of group and time on the dependent variables.<br> Results: The hand-massaged group showed greater increases in skin temperature than the control group, as shown by ANOVA (p<.05). Results showed that improvements of the scores in the questionnaire (condition and feel-good items) were greater in the hand-massaged group than in the control group (p<.05). Cortisol level increased in the control group, but was not statistically significantly different from that in the hand-massaged group, as shown by ANOVA. Chromogranin A level was also not significantly different between the two groups.<br> Conclusions: These results confirmed the benefits of complementary and alternative medicine including touching and massage found in previous studies. Hand massage prompted relaxation in geriatric facility residents in this experiment.<br>

    DOI CiNii

  • Interpretation of the results of multivariate analyses

    Kazumasa Tsukamoto, Kazuhiko Machida

    JOURNAL OF CARDIOLOGY   61 ( 1-2 ) 95 - 95  2013.01

    Rapid communication, short report, research note, etc. (scientific journal)  

    DOI

  • Effects of life events and stress on neutrophil functions in elderly men

    Kazumasa Tsukamoto, Kazuhiko Machida

    IMMUNITY & AGEING   9 ( 1 ) 1 - 5  2012.06

    　View Summary

    Background: Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail. We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years.
    Results: The numbers and scores for life events were significantly higher (p&lt;0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group.
    Conclusions: Chronic psychological stress due to life events decreases neutrophil functions among elderly men.

    DOI

  • Effects of life events and stress on neutrophil functions in elderly men

    Kazumasa Tsukamoto, Kazuhiko Machida

    IMMUNITY & AGEING   9 ( 1 ) 1 - 5  2012.06

    　View Summary

    Background: Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail. We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years.
    Results: The numbers and scores for life events were significantly higher (p&lt;0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group.
    Conclusions: Chronic psychological stress due to life events decreases neutrophil functions among elderly men.

    DOI

  • A Nutrition Survey of Atherosclerosis Patients to Study the Effects of Iron, Zinc, and Copper on Atherosclerosis

      29   110 - 116  2012

    CiNii

  • A Nutrition Survey of Atherosclerosis Patients to Study the Effects of Iron,Zinc,and Copper on Atherosclerosis

    N shida,YTsychiya, F, yamakura,T Kano, Y, Nakazato, K, Takada, S Kawai, K Ikeda, Y Amamiya, S Nakajima, K Machida,H Iwai

    Trace Nutrition Research   29   110 - 116  2012

    CiNii

  • Changes in Mental Health Index, Serum Biochemical Parameters and Neutrophil Function after Start of the Wheelchair Use at a Nursing Home in Korea

    SHIDA Naoki, KURODA Kumiko, KWAG Joung-Ouk, MACHIDA Kazuhiko

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)   67 ( 1 ) 67 - 75  2012

    　View Summary

    Objectives: In Korea, long-term care insurance has been provided to the elderly since 2008. We conducted a health survey of the elderly in a nursing home in Korea from 2007 to 2010. Since the introduction of the insurance system, many of the elderly have started using wheelchairs. We aimed to determine the effect of using wheelchairs on mental health index, serum biochemical parameters, and neutrophil function.<br> Methods: The subjects were 32 elderly persons (mean age: 74.44±5.79 years) who could walk unaided in 2007 and were not bedridden until 2010. We classified the subjects into the walking group (subjects could walk unaided or with a cane until 2010; 10 men, 9 women) and the wheelchair group (subjects required the use of a wheelchair from 2007 to 2010; 2 men, 11 women).<br> We determined stress score, stress tolerance, subjective well-being score in accordance with the Philadelphia Geriatric Center Morale Scale, and serum biochemical parameters. We also analyzed oxidant production and phagocytosis by neutrophils and estimated the balance between oxidant production and phagocytosis by correlation analysis.<br> Results: Increases in the stress tolerance of the wheelchair group in 2008 and 2009 and the subjective well-being score in 2009 in the survey were observed. However, in 2010, the stress tolerance and the subjective well-being score decreased to the levels in 2007. In 2010, the levels of serum albumin and high-density lipoprotein cholesterol of the wheelchair group were significantly lower than those of the walking group, and the balance between phagocytosis and oxidant production in the wheelchair group improved.<br>

    DOI CiNii

  • 中国天津市在住の高齢者における抑うつ・身体的・心理的・社会的要因との関連

    片山佳代子, 町田和彦

    民族衛生   78 ( 1 ) 3 - 15  2012

    DOI CiNii

  • 高齢者の健康とインフルエンザに関する意識調査ー新型インフルエンザの流行を顧みて

    土屋洋子, 三谷若菜, 尾中俊介, 町田和彦

    日本衛生学雑誌   65 ( 2 ) 507  2011

  • 保育園に通う３・４・５歳児の体格と生活との関連

    泉秀生, 町田和彦

    日本衛生学雑誌   66 ( 2 ) 446  2011

  • 車いす使用者の好中球機能・血清生化学検査値・心的健康指標の変化

    信太直哉, 岩井秀明, 町田和彦

    日本衛生学雑誌   66 ( 2 ) 381  2011

  • 韓国高齢者福祉施設入居者のQOLと唾液中ホルモンとの関係

    源田知美, 信太直己, 片桐千佳, 町田和彦

    体力・栄養・免疫学会   21 ( 2 )  2011

  • 幼児の生活実態に関する研究―保育園５・６歳児とその保護者の１週間の生活記録分析―

    泉秀生, 前橋明, 町田和彦

    保育と保健   17 ( 2 ) 75 - 79  2011

  • 朝の排便時間帯別に見た保育園５・６歳児の生活実態

    泉秀生, 前橋明, 町田和彦

    厚生の指標   58 ( 13 ) 7 - 11  2011

  • Effect of Lifestyle and Health Behavior on Neutrophil Function : Assessed by Nitroblue Tetrazolium Reduction Method Using Neutrophils in Elderly in Tianjin, China

    KATAYAMA Kayoko, WANG Meihua, OGAWA Namiko, IKEHARA Satoyo, XIA Mu-Qun, LIU Chun-Yan, MACHIDA Kazuhiko

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)   66 ( 3 ) 573 - 581  2011

    　View Summary

    Objective: In this study, we investigated the relationships of neutrophil functions with lifestyle factors (namely, subjective stress, exercise habits, smoking habits, alcohol-drinking habits, and self-perceived status health) and health behavior in the Chinese urban elderly.<br> Methods: We performed a health survey of the elderly aged 65 years or older living in Tianjin. The subjects were 42 males (69.1±4.1 years old) and 41 females (69.1±4.1 years old). Investigations of subjective stress, exercise habits, smoking habits, alcohol-drinking habits, and self-perceived health status were performed. The phagocytosis and superoxide productivity of neutrophils were measured by the nitroblue tetrazolium (NBT) reduction method. In addition, leukocyte count and serum total protein (TP) level were examined.<br> Results: The investigations revealed the associations of health behavior (p<0.05) and self-perceived health (p<0.10) with the balance between phagocytosis and subsequent superoxide production.<br> Conclusions: The present study revealed that there were correlations of neutrophil functions with lifestyle factors (subjective stress, exercise habits, smoking habits, alcohol-drinking habits, and self-perceived status health) and health behavior in the Chinese urban elderly.<br>

    DOI CiNii

  • Impacts of physical,mental,and sosioeconomic factor on the outpatient medical care cost of the Chinese elderly:Health survey of the elderly living inTianjin

    Kayoko Katayama, Chun-yYan Liu, Mu-Xia, Naoto Kawahara, Kazuhiko Machida

    Jpn Health $ Ecology   77 ( 6 ) 227 - 238  2011

    DOI CiNii

  • Impacts of physical,mental,and sosioeconomic factor on the outpatient medical care cost of the Chinese elderly:Health survey of the elderly living inTianjin

    Kayoko Katayama, Chun-yYan Liu, Mu-Xia, Naoto Kawahara, Kazuhiko Machida

    Jpn Health $ Ecology   77 ( 6 ) 227 - 238  2011

    DOI CiNii

  • 子供のワクチン接種に関する母親の意識調査

    土屋洋子, 小笠原真美, 小川恵美子, 町田和彦

    日本衛生学雑誌   65 ( 2 ) 388  2010

  • 高齢者の睡眠とストレスの関連―中国廈門での調査結果―

    信太直己, 呉晨, 岩井秀明, 町田和彦

    日本衛生学雑誌   65 ( 2 ) 328  2010

  • 幼児の生活実態に関する考察―保育園児の朝食けっ食と生活実態の関連

    泉秀生, 町田和彦

    日本衛生学雑誌   65 ( 2 ) 284  2010

  • ストレスと非特異免疫

    町田和彦

    日本衛生学雑誌   65 ( 2 ) 228  2010

  • 子供の予防接種に関する母親調査：子供の構成に注目して

    土屋洋子, 町田和彦

    体力・栄養・免疫学雑誌   20   202 - 204  2010

  • 唾液中副腎皮質ホルモン測定における唾液採取法と室温保存の影響

    小川奈美子, 伊澤修平, 野村忍, 町田和彦

    生理心理学と精神生理学   28 ( 3 ) 219 - 224  2010

    DOI CiNii

  • 高齢者の運動習慣における血清脂質とＢＭＩとの関連性～日本(狭山)と中国(天津)の調査より

    小名絵里香, 森下玲次, 町田和彦

    日本衛生学雑誌   64   557  2009

  • 動脈硬化症患者の進行度による栄養充足率及び血清中微量金属元素濃度の違い

    信太直己, 町田和彦, 岩井秀明

    体力・栄養・免疫学雑誌   19 ( 2 ) 178 - 181  2009

  • 保育園児の日中の身体活動量と睡眠との関係

    泉 秀生, 町田和彦

    体力・栄養・免疫学雑誌   19 ( 2 ) 166 - 168  2009

  • 動脈硬化症患者と健常者の栄養充足率及び血清中微量金属元素濃度の比較

    信太直己, 池田啓一, 雨宮有子, 高田和子, 加納達二, 中里祐二, 加部勇, 町田和彦, 岩井秀明

    日本衛生学雑誌   64   601  2009

  • 韓国における施設高齢者と在宅高齢者の食生活の関連

    小名絵里香, 信太直己, 町田和彦

    体力・栄養・免疫学雑誌   19 ( 2 ) 156 - 158  2009

  • 中国天中国天津市老人ホームの実態

    呉晨, 町田和彦

    体力・栄養・免疫学雑誌   19 ( 2 ) 144 - 148  2009

  • 韓国高齢者福祉施設入居者の感染者の感染症リスク因子と予防

    土屋洋子, 町田和彦

    体力・栄養・免疫学雑誌   19 ( 2 ) 142 - 143  2009

  • 韓国校正者施設入居者の精神的健康と身体活動

    黒田久美子, 町田和彦

    体力・栄養・免疫学雑誌   19 ( 2 ) 138 - 141  2009

  • テキストマイニングによる特別老人ホームにおける総合的品質経営の課題に関する探索的分析

    扇原淳, 武藤允, 山路学, 町田和彦

    介護経営     45 - 58  2009

  • 中国都市部高齢者のメタボリックシンドロームと一日平均歩数との関係

    王美華

    日本疫学会   18 ( 1 ) 225  2008

  • 高齢者の抑うつと主観的体力感との関連ー中国天心市在住高齢者とした疫学研究よりー

    片山佳代子, 王美華, 稲葉裕, 町田和彦

    日本疫学会   18 ( 1 ) 226  2008

  • 東北地域の高齢者における生涯学習活動と心身の健康の関連

    宮本真, 平塚克史, 町d和彦

    日本衛生学雑誌   63 ( 2 ) 570  2008

  • 中国高齢者のメタボリックシンドロームと生活習慣の関連

    王美華, 片山佳代子, 町田和彦, 黒沢美智子, 稲葉裕

    日本衛生学雑誌   63 ( 2 ) 569  2008

  • Relationship of metabolic syndrome and number of steps in dailylife among urban elderly in China

    WANG MEIHUA, KATAYAMA KAYOKO, MATIDA KAZUHIKO, KUROSAWA MITIKO, INABA YUTAKA

    Juntendo medical journal   54 ( 2 ) 166 - 175  2008

    　View Summary

    Objective : With China's rapid economic development, the incldeuce of lifestyle-related diseases has increased and a high prevalence of metabolic syndrome (MS)has been reported. This study investigated the relationship between metabolic syndrome and steps/day among urban elderly in China by collecting 365 days of continuous self-monitored pedometer data. Materials '. We recruited 200 elderly subjects to participate in our study among 9167 community residents aged 65 or more years old who were registered at a community hospital-「WangDingTi Hospital」 in the NANKAI distract in Tianjin City, China. Of these 200 elderly subjects, we analyzed 90 participants who completed questionnaires on lifestyle factors in March 2004, underwent repeated medical checkups in March 2004 and February 2005 as well as recorded pedometer data through out 2004. Methods : All participants received a pedometer (OMRON HJ_002) and were instructed to record total steps per day during their usual activity for any three days per week during waking hours throughout one year. We summed the total steps on any three days per week for one year and then divided the recorded data to determine the average dailylife steps/day (steps/day) in this study. MS was diagnosed using the Chinese Diabetes Society 2004 (CDS)criterion. In our study,we called the MS group (50 participants)who were diagnosed ashaving MS eitherin March 2004 or in February 2005 and the NON-MS group (40 participants) who were not diagnosed as having MS on either of the two medical checkups. We used SPSS11.0J for statistical analysis. Result : Ninetyparticipants (49men, 41women),with a mean age ±SD of 70.2±4.6years showed a mean value of 5509±3480 steps/day, There was a significant difference between the MS group (4811±2580 steps/day) and the NON-MS group (6380±4226 steps/day) (p=0.043). Compared to the number of steps/dayby subjects without any component of MS, that of those with 1-4 MS components was significantly lower (p=0.004). In addition, the steps/dayin the obesitygroup (BMI≧25 (Kg/m^2)) wasless than that in the normal weight group (BMI<25 (Kg/m^2)) (P=0.004), the steps/day in the high diastolic blood pressure (DBP≧90mmHg) group was less than thatin the DBP<90mmHg group (P=0.045). When we performed categorical analysis using cut off points of 5000, 6000, 7000 and 8000 steps/day, a cut off point over 6000 steps/day showed a significant difference between normal weight and obesity group, and a cut off point of 8000 steps/day showed significant difference between the normal weight and obesity group as well as between the high diastolic blood pressure and normal diastolic blood pressure group, respectively. After using sex and the age-adjusted logistic regression model, the risk of obesity was significantly lower over 5000 steps/day and the risk of obesity and high diastolic blood pressure were significantly lower over 8000 steps/day. Moreover, the more components of MS other than BMI,the higher the average BMI became. Conclusion : This study showed that metabolic syndrome was closely associated with the number of daily-life steps/day among urban elderly in China. In subjects with over 5000 steps/day, BMI was lower, and in those with over 8000 steps/day, both BMI and DBP were significantly lower.

    DOI CiNii

  • Awakening response and QOL in the hospice hospitalixed terminal cancer patient

    Ogawa,N.,Hu,S, Zhang,D.,Feng, W.Machida,K

    39ｔｈ Ａｎｎｕａｌ Ｉｎｔ．Ｓｏｃ．Ｐｓｙｃｈｏｎｅｕｒｏｅｎｄｏｃｒｉｎｏｌｏｇｙ Ｃｏｎｆｅｒｅｎｃｅ   Abstract Book   122  2008

  • 高齢者の食生活と血清脂質の関連性～日本（狭山）と中国（天津）の調査より～

    小名絵里香, 張替まき, 夏睦群, 劉チュンヤン, 町田和彦

    第73回日本民族衛生学会総会講演集     190 - 191  2008

  • Awakening response and QOL in the hospice hospitalixed terminal cancer patient

    Ogawa,N.,Hu,S, Zhang,D.,Feng, W.Machida,K

    39ｔｈ Ａｎｎｕａｌ Ｉｎｔ．Ｓｏｃ．Ｐｓｙｃｈｏｎｅｕｒｏｅｎｄｏｃｒｉｎｏｌｏｇｙ Ｃｏｎｆｅｒｅｎｃｅ   Abstract Book   122  2008

  • Episodic stress associated with writing a graduation thesis and free cortisol secretion after awakening

    Shuhei Izawa, Nagisa Sugaya, Namiko Ogawa, Yuichiro Nagano, Masako Nakano, Emiko Nakase, Kentaro Shirotsuki, Kosuke Chris Yamada, Kazuhiko Machida, Masahisa Kodama, Shinobu Nomura

    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY   64 ( 2 ) 141 - 145  2007.05

    　View Summary

    Cortisol secretion after awakening, an index of hypothalamus-pituitary-adrenal axis activity, appears to be related to psychosocial stressors, or to symptoms caused by psychosocial stressors. The relationship between the quality, duration, and magnitude of psychosocial factors and cortisol secretion is however, unclear. Therefore, the effect of episodic stress associated with writing a graduation thesis on cortisol secretion after awakening was investigated. Saliva samples were collected from 10 undergraduate students at awakening, and 30, 45, and 60 min after awakening 1 month, 2 weeks, and a few days before the thesis submission and 1 week after the submission. They also completed the Short form of Profile of Moods Scale (POMS-S) on the night before each sampling. Results indicated that cortisol levels were higher a few days before the thesis submission compared to 1 month before submission. Scores of "Fatigue" and "Tension-Anxiety" in POMS-S were also higher a few days before submission. These results suggest that episodic stress associated with writing a graduation thesis caused an increase in cortisol levels after awakening. (c) 2007 Elsevier B.V. All rights reserved.

    DOI

  • 日本語版The Trier Inventory for the Assessment of Chronic Stress(TICS)の研究

    小川奈美子, 宮元真, 片山佳代子, 町田和彦

    民族衛生〔第71回日本民族衛生学会総会口演集]   72 ( 付録 ) 224 - 225  2007

  • 日本（狭山）・韓国（山清）・中国天津）における地域高齢者の食生活比較検討

    張替まき, 小川美奈子, 山崎貴裕, 町田和彦

    体力栄養免疫学会   17 ( 2 )  2007

  • Depressive symptoms,social support and medical behavior among the chinese elderly

    Kayoko Katayama, Meihua Wang, Yutaka Inaba, Kazuhiko Machida

    The ３９ th conference of Asia-Pacific academic consrtium for public Healrh   abstrct book  2007

  • A study on relationship of pedometer-determined ambulatory activity to indicators of health among chinese elderly people

    Meihua Wang, Kayoko Katayama, Kazuhko Machida, Yutaka inaba

    The ３９thConference of Asia-Pacific Academic Consortium for Public Health   abstract book  2007

  • The relationship between stress and lifestyle in the elderly

    Naoki Shida, Naoto Kwahara, Ye Xiong, Kyoko Yamazaki, Yuko Aoyama, Hideki Iwai, Kazuhiko Machida

    J Physic Fit Nutr Immnol   17 ( 2 ) 61 - 67  2007

  • Depressive symptoms,social support and medical behavior among the chinese elderly

    Kayoko Katayama, Meihua Wang, Yutaka Inaba, Kazuhiko Machida

    The ３９ th conference of Asia-Pacific academic consrtium for public Healrh   abstrct book  2007

  • A study on relationship of pedometer-determined ambulatory activity to indicators of health among chinese elderly people

    Meihua Wang, Kayoko Katayama, Kazuhko Machida, Yutaka inaba

    The ３９thConference of Asia-Pacific Academic Consortium for Public Health   abstract book  2007

  • The relationship between stress and lifestyle in the elderly

    Naoki Shida, Naoto Kwahara, Ye Xiong, Kyoko Yamazaki, Yuko Aoyama, Hideki Iwai, Kazuhiko Machida

    J Physic Fit Nutr Immnol   17 ( 2 ) 61 - 67  2007

  • Clock mutation affects circadian regulation of circulating blood cells

    Katsutaka Oishi, Naoki Ohkura, Koji Kadota, Manami Kasamatsu, Kentaro Shibusawa, Juzo Matsuda, Kazuhiko Machida, Shuichi Horie, Norio Ishida

    Journal of Circadian Rhythms   4  2006.10

    　View Summary

    Background: Although the number of circulating immune cells is subject to high-amplitude circadian rhythms, the underlying mechanisms are not fully understood. Methods: To determine whether intact CLOCK protein is required for the circadian changes in peripheral blood cells, we examined circulating white (WBC) and red (RBC) blood cells in homozygous Clock mutant mice. Results: Daytime increases in total WBC and lymphocytes were suppressed and slightly phase-delayed along with plasma corticosterone levels in Clock mutant mice. The peak RBC rhythm was significantly reduced and phase-advanced in the Clock mutants. Anatomical examination revealed hemoglobin-rich, swollen red spleens in Clock mutant mice, suggesting RBC accumulation. Conclusion: Our results suggest that endogenous clock-regulated circadian corticosterone secretion from the adrenal gland is involved in the effect of a Clock mutation on daily profiles of circulating WBC. However, intact CLOCK seems unnecessary for generating the rhythm of corticosterone secretion in mice. Our results also suggest that CLOCK is involved in discharge of RBC from the spleen. © 2006 Oishi et al
    licensee Biomed Central Ltd.

    DOI

  • Extended light exposure suppresses nocturnal increases in cytotoxic activity of splenic natural killer cells in rats

    K Oishi, K Shibusawa, H Kakazu, T Kuriyama, N Ohkura, K Machida

    BIOLOGICAL RHYTHM RESEARCH   37 ( 1 ) 29 - 35  2006.02

    　View Summary

    To understand light-induced immune modulation in vivo, we evaluated the effect of nocturnal light exposure on splenic natural killer (NK) cell activity in rats. Nocturnal increases in the number and cytotoxic activity of NK cells were significantly suppressed under extended light exposure. Nocturnal increases in serum corticosterone levels were also suppressed by light exposure, suggesting that the light exposure-induced decrease in NK cell functions was not due to stress-induced glucocorticoid secretion in rats. These results suggest that nocturnal light exposure could profoundly affect NK cell functions perhaps through eye-brain hormonal modulation.

    DOI

  • Relationship between Lifestyle and Oral Health in Chinese Elderly

    KOYAMA Yoshito, MACHIDA Kentaro, KATAYAMA Kayoko, OGAWA Namiko, IKEHARA Satoyo, XIA Mu-Qun, LIU Chun-Yan, MACHIDA Kazuhiko

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)   61 ( 1 ) 53 - 62  2006

    　View Summary

    Objective: Oral health is very important particularly for elderly to live happily. The purpose of this study is to clarify the relationship between lifestyle and oral health in Chinese elderly.<br>Methods: The subjects were 96 men (mean±SD: 70.1±4.9) and 92 women (70.7±5.4). Oral health status was evaluated according to the numbers of remaining, intact, treated, and untreated teeth and score in WHO's CPI code. By carrying out a questionnaire survey, we evaluated lifestyle factors, such as stress (SCLS), smoking habits, drinking habit, sleeping hours, sports, snack habit, and tooth brushing habit. Logistic regression analysis was used in analyzing the data.<br>Results: By multi-logistic regression analysis, men who smoke were more likely to have a lower CPI score than those who do not {odds ratio (OR)=4.69, 95% confidence interval (95% CI)=0.79-27.89, p<.10}. Men who brush their teeth less than once a day are less likely to have a lower CPI score than those who brush their teeth more than twice a day (OR=0.33, 95% CI=0.09-1.22, p<.10). On the other hand, women who experience much stress are more likely to have a lower CPI score than women who experience little stress (OR=5.59, 95% CI=1.29-24.15, p<.05).<br>Conclusions: The study indicated that smoking may affect oral health conditions in men, whereas stress may affect oral health conditions in women. The reduction in stress and abstinence from smoking are important in maintaining good oral health in Chinese elderly.

    DOI PubMed CiNii

  • 高齢者健康調査に見る健康意識と生活習慣の改善の重要性ーセルフケアと自己決定の視座を踏まえてー

    河原直人, 信太直己, 町田和彦

    Geriattric Medicine   44 ( 1 ) 77 - 80  2006

  • 万歩計を用いた身体活動量と健康状態との関係

    坂田晴美, 片山佳代子, 田中健雄, 小川美奈子, 町田和彦

    日本衛生学会雑誌   61 ( 2 ) 260  2006

  • 中国在住高齢者の生活習慣とMSとの関連

    小川奈美子, 片山佳代子, 王美華, 町田和彦

    日本衛生学会雑誌   61 ( 2 ) 260  2006

  • 加齢と免疫機能の関係

    信太直己, 趙譚, 雨宮有子, 岩井秀明, 町田和彦

    日本衛生学会雑誌   61 ( 2 ) 277  2006

  • Recent Heavy Metal Concentration in Watarase Basin around Ashio mine

    Ohmichi,K.,Seno, Yoshitaka,S, Takahashi,A, Kojima,Koichi, Niyammoto,H, Ohmichi,M, Matsuki,Y, Machida,K

    J Health Science   52 ( 4 ) 465 - 468  2006

    DOI CiNii

  • Salivery cortisol secretion and autonomic nerve activity during the early morning period in stressed and non-stressed subjects

    Ogawa N, Izawa S, Sugaya N, Yamamoto R, Machida.K, Nomura S

    Ninth International Congress of Behavioral medicine   abstrct book  2006

  • Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice

    K Oishi, G Atsumi, S Sugiyama, Kodomari, I, M Kasamatsu, K Machida, N Ishida

    FEBS LETTERS   580 ( 1 ) 127 - 130  2006.01

    　View Summary

    The Clock gene is a core component of the cireadian clock in mammals. We show here that serum levels of triglyceride and free fatty acid were significantly lower in circadian Clock mutant ICR than in wild-type control mice, whereas total cholesterol and glucose levels did not differ. Moreover, an increase in body weight induced by a high-fat diet was attenuated in homozygous Clock mutant mice. We also found that dietary fat absorption was extremely impaired in Clock mutant mice. Circathan expressions of cholecystokinin-A (CCK-A) receptor and lipase mRNAs were damped in the pancreas of Clock mutant mice. We therefore showed that a Clock mutation attenuates obesity induced by a high-fat diet in mice with an ICR background through impaired dietary fat absorption. Our results suggest that circadian clock molecules play an important role in lipid homeostasis in mammals. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    DOI PubMed CiNii

  • Recent Heavy Metal Concentration in Watarase Basin around Ashio mine

    Ohmichi,K.,Seno, Yoshitaka,S, Takahashi,A, Kojima,Koichi, Niyammoto,H, Ohmichi,M, Matsuki,Y, Machida,K

    J Health Science   52 ( 4 ) 465 - 468  2006

    DOI CiNii

  • Salivery cortisol secretion and autonomic nerve activity during the early morning period in stressed and non-stressed subjects

    Ogawa N, Izawa S, Sugaya N, Yamamoto R, Machida.K, Nomura S

    Ninth International Congress of Behavioral medicine   abstrct book  2006

  • 居住環境が高齢者の食生活様式に及ぼす影響

    寺田修, 町田和彦

    体力・栄養・免疫学会   15 ( 2 ) 132 - 134  2005

    CiNii

  • Improving ｂioactivities of Soy Isofulavons by deglycosilation using recombinant Β-D-glucosidase from Bifidobacterium breva

    S.nakamura, H.Iwai, K.Machida, F.Fukui, F.Yamakura, N.Sato

    95th AOCS Annual Meeting & Expo   abstract   115  2005

  • 大学生の健康生活習慣

    片山佳代子, 坂口早苗, 坂口武洋, 町田和彦

    体力・栄養・免疫学会   14 ( 2 ) 141 - 143  2005

  • 音楽が状態不安に及ぼす不安軽減効果について

    小川奈美子, 町田和彦

    体力・栄養・免疫学会   14 ( 2 ) 144 - 146  2005

  • 中国天津市在住高齢者の生活習慣、歯科保健と外来医療費との関連

    小山吉人, 片山佳代子, 小川奈美子, 溝口竜太, 池原賢代, 信太直人, 町田和彦

    日本衛生学雑誌   60 ( 2 ) 279  2005

  • 中国地域高齢者の主観的健康感およびADLに関する要因

    池原賢代, 溝口竜太, 片山佳代子, 小川奈美子, 信太直己, 町田和彦

    日本衛生学会   60 ( 2 ) 279  2005

  • 中国在住高齢者の生きがいと生活習慣病との関連

    小川奈美子, 片山佳代子, 池原賢代, 溝口竜太, 町田和彦

    日本衛生学雑誌   60 ( 2 ) 279  2005

  • 中国公費受給者における保健行動と医療費との関連

    片山佳代子, 小川奈美子, 溝口竜太, 池原賢代, 小山吉人, 町田和彦

    日本衛生学雑誌   60 ( 2 ) 279  2005

  • 自立したケアシステムと医療

    町田和彦

    未来医療政策研究所シンポジューム     24 - 25  2005

  • The water quality study of the river and tap water in the Watarase, Tone and Edo river system by ion chromatograph

    OHMICHI Kimihide, MIYAMOTO Hiroshi, OHMICHI Masayoshi, MACHIDA Kazuhiko

    Japanese Journal of Health and Human Ecology   71 ( 3 ) 124 - 130  2005

    　View Summary

    In order to understand the behaviors of soluble chemical species at the confluence of the river water and water supply process, the Watarase, Tone, and Edo River System was studied in regard to the inorganic ion. This river system starts from the base of the Ashio copper mine and ends at Tokyo Bay. Along the rivers, there are 14 local municipalities in Gunma, Saitama, Ibaragi and Chiba Prefectures, as well as Tokyo . This area is center of the Kanto plain and includes the main source of water pollution from human activities . Moreover, the water of the river system is the source water for human activities in Kanto area. Also, we analyzed some chemical species to clarify water environmental status and outline the problems of water environment in research area. Water samples from 18 river sites and 42 water faucets at public facilities from Watarase, Tone, and Edo basin which include 14 local municipalities were collected and the degree of contamination was analyzed. The chemical species in river and top wa er were analyzed by ion chromatograph. Overall, it was thought that the Cl- of river water in the Watarase, Tone, Edo Basin contributed more large effect to water pollution than NO32- did . It was revealed the present water filtration plant procedures change the mineral balance of water. But, a good correlation in some ion elements between the river and tap water was found . For example, the correlation coefficients of Mg2+ and Ca2+ between them were 0 .912 and 0.969, respec tively. Also, it was confirmed the concentrations of Ca2+ and Na+ showed characteristic changes as the functions of location. These results may be important in the understanding of distribution behaviors of ionic chemical elements in this area.

    DOI CiNii

  • 高齢者のライフスタイルおよび身体機能が医療費に及ぼす影響

    河原直人, 信太直己, 町田和彦

    日本公衆衛生雑誌   52 ( 8 ) 521  2005

  • 中国都市在住者の抑うつとその関連要因について

    片山佳代子, 小川奈美子, 町田和彦

    第７０回の本民族衛生学会総会講演集     88 - 89  2005

  • 中国天津市高齢者１年間の健康増進運動の血圧尾変化についての解析

    王美華, 町田和彦, 稲葉裕, 片山佳代子, 小川奈美子

    第７０回日本民族衛生学会総会講演集     84 - 85  2005

  • 中国在住高齢者のストレスと生活習慣病との関連

    小川美奈子, 片山佳代子, 町田和彦

    第７０回日本民族衛生学会総会講演集     86 - 87  2005

  • Improving ｂioactivities of Soy Isofulavons by deglycosilation using recombinant Β-D-glucosidase from Bifidobacterium breva

    S.nakamura, H.Iwai, K.Machida, F.Fukui, F.Yamakura, N.Sato

    95th AOCS Annual Meeting & Expo   abstract   115  2005

  • Volatile Organic Compounds of the Tap Water in the Watarase, Tone and Edo River System

    OHMICHI Kimihide, OHMICHI Masayoshi, MACHIDA Kazuhiko

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)   59 ( 1 ) 45 - 50  2004

    　View Summary

    Objectives: The chlorination of river water in purification plants is known to produce carcinogens such as trihalomethanes (THMs). We studied the river system of the Watarase, Tone, and Edo Rivers in regard to the formation of THMs. This river system starts from the base of the Ashio copper mine and ends at Tokyo Bay. Along the rivers, there are 14 local municipalities in Gunma, Saitama, Ibaragi and Chiba Prefectures, as well as Tokyo. This area is the center of the Kanto plain and includes the main sources of water pollution from human activities. We also analyzed various chemicals in river water and tap water to clarify the status of the water environment, and we outline the problems of the water environment in the research area (Fig. 1).<br>Methods: Water samples were taken from 18 river sites and 42 water faucets at public facilities in 14 local municipalities. We analyzed samples for volatile organic compounds such as THMs, by gas chromatography mass spectrometry (GC-MS), and evaluations of chemical oxygen demand (COD) were made with reference to Japanese drinking water quality standards.<br>Results: Concentrations of THMs in the downstream tap water samples were higher than those in the samples from the upperstream. This tendency was similar to the COD of the river water samples, but no correlation between the concentration of THMs in tap water and the COD in tap water sources was found. In tap water of local government C, trichloroethylene was detected.<br>Conclusions: The current findings suggest that the present water filtration plant procedures are not sufficient to remove some hazardous chemicals from the source water. Moreover, it was confirmed that the water filtration produced THMs. Also, trichloroethylene was detected from the water environment in the research area, suggesting that pollution of the water environment continues.

    DOI PubMed CiNii

  • Inorganic elements of Tap and River Water in the Watarase, Tone and Edo River System

    OHMICHI Kimihide, MIYAMOTO Hiroshi, OHMICHI Masayoshi, MACHIDA Kazuhiko

    Biomedical research on trace elements   15 ( 1 ) 54 - 61  2004

    DOI CiNii

  • 日本の医療の問題点と個人の自立

    町田和彦

    未来医療政策研究所2004年度研究報告会[豊かな医療へのコラボレーションー人、政策、空間、システムー]     48 - 49  2004

  • 埼玉県某村における保健行動と医療費に関する研究

    体力・栄養・免疫学雑誌   13(3)   225 - 226  2004

  • 高齢者の血清中抗酸化物質と酸化バランスに及ぼす運動習慣に関する実態研究

    熊江隆, 町田和彦, 中路重之, 菅原和夫

    体力・栄養・免疫学雑誌   13(3)   227 - 229  2004

  • 高齢者の飲酒習慣が好中球機能に及ぼす影響

    池原賢代, 町田和彦

    体力・栄養・免疫学会雑誌   13 ( 3 ) 230 - 231  2004

  • 高齢者における生活習慣と血清脂質の関連

    日本衛生学雑誌   59(2)   185  2004

  • フラボノイドによる抗癌作用

    日本衛生学雑誌   59(2)   171  2004

  • トリブチル錫のMC3T3-E１細胞ＡＬＰ活性に及ぼす影響

    日本衛生学雑誌   59(2)   150  2004

  • Flow cytometry 法を用いた好中球貪食能/殺菌能の測定

    日本衛生学雑誌   59(2)   194  2004

  • Inproveing Bioactivities of Soy Isoflavons by deglycosilation using recombinant β-D-glucosidase from Bifidobacterium breve

    S.Nakamura, H.Iwai, K.Machida, F.Fukui, F.Yamakura, N.Sato

    95thAOCS Annual Meeting & Expo   abstracts   115  2004

  • 健康な食生活とライフスタイル

    町田和彦

    新鐘   ( 70 ) 46 - 49  2004

  • 人の社会と感染症

    町田和彦

    保健の科学   46 ( 8 ) 556 - 560  2004

  • 健康感と身体機能および医療費との関係<中国天津における調査結果＞

    信太直己, 片山佳代子, 池原賢代, 溝口立太, 岩井秀明, 町田和彦

    日本公衆衛生学雑誌   51 ( 10 ) 735  2004

  • 感染症におけるリスクマネージメントと今後のあり方

    町田和彦

    安全医学   1 ( 2 ) 43 - 47  2004

  • 地域高齢者の血清中抗酸化物質と酸化・抗酸化バランスに及ぼす運動習慣の影響

    熊江隆, 町田和彦, 中路重之, 菅原和夫

    体力・栄養・免疫学雑誌   14 ( 3 ) 237 - 246  2004

  • Inproveing Bioactivities of Soy Isoflavons by deglycosilation using recombinant β-D-glucosidase from Bifidobacterium breve

    S.Nakamura, H.Iwai, K.Machida, F.Fukui, F.Yamakura, N.Sato

    95thAOCS Annual Meeting & Expo   abstracts   115  2004

  • Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes

    K Oishi, K Miyazaki, K Kadota, R Kikuno, T Nagase, G Atsumi, N Ohkura, T Azama, M Mesaki, S Yukimasa, H Kobayashi, C Iitaka, T Umehara, M Horikoshi, T Kudo, Y Shimizu, M Yano, M Monden, K Machida, J Matsuda, S Horie, T Todo, N Ishida

    JOURNAL OF BIOLOGICAL CHEMISTRY   278 ( 42 ) 41519 - 41527  2003.10

    　View Summary

    CLOCK is a positive component of a transcription/ translation-based negative feedback loop of the central circadian oscillator in the suprachiasmatic nucleus in mammals. To examine CLOCK-regulated circadian transcription in peripheral tissues, we performed microarray analyses using liver RNA isolated from Clock mutant mice. We also compared expression profiles with those of Cryptochromes (Cry1 and Cry2) double knockout mice. We identified more than 100 genes that fluctuated from day to night and of which expression levels were decreased in Clock mutant mice. In Cry-deficient mice, the expression levels of most CLOCK-regulated genes were elevated to the upper range of normal oscillation. Most of the screened genes had a CLOCK/BMAL1 binding site (E box) in the 5'-flanking region. We found that CLOCK was absolutely concerned with the circadian transcription of one type of liver genes ( such as DBP, TEF, and Usp2) and partially with another ( such as mPer1, mPer2, mDec1, Nocturnin, P450 oxidoreductase, and FKBP51) because the latter were damped but remained rhythmic in the mutant mice. Our results showed that CLOCK and CRY proteins are involved in the transcriptional regulation of many circadian output genes in the mouse liver. In addition to being a core component of the negative feedback loop that drives the circadian oscillator, CLOCK also appears to be involved in various physiological functions such as cell cycle, lipid metabolism, immune functions, and proteolysis in peripheral tissues.

    DOI PubMed CiNii

  • Differential effects of physical and psychological stressors on immune functions of rats

    K Oishi, N Nishio, K Konishi, M Shimokawa, T Okuda, T Kuriyama, K Machida

    STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS   6 ( 1 ) 33 - 40  2003.03

    　View Summary

    To study the effects of different types or durations of stressors on immune functions, male Fischer rats were exposed to chronic physical (electric foot shock) or psychological (non-foot shock) stress induced in the communication box. Superoxide production by alveolar macrophages (AMs), mitogen-induced splenic lymphocyte proliferation, and splenic natural killer (NK) cell cytolysis were examined in vitro. Repeated exposure to physical stress suppressed superoxide production by AMs (-58%, p &lt; 0.05 for opsonized zymosan (OZ) and -51%, p &lt; 0.05 for phorbol 12-myristate 13-acetate (PMA)), although psychological stress suppressed superoxide production after 24 h of repeated exposures (-40%, p &lt; 0.05 for OZ and -47%, p &lt; 0.05 for PMA). Acute suppression of the blastic response of splenic lymphocytes was only found in the physical stress group (p &lt; 0.05), although the chronic effects were only found in the psychological stress group (p &lt; 0.05). NK cell activity was suppressed immediately after the acute physical stress (-30%, p &lt; 0.05), but no effects were found in the psychological stress group. These results underline the importance of distinguishing between physical versus psychological stressors when examining the effects of stress on immune functions.

    DOI

  • 万歩計を用いた高齢者の運動評価と健康指標との関連性

    体力・栄養・免疫学雑誌   13 ( 2 ) 132 - 141  2003

  • 高齢者の体力、活動能力およびストレス反応性とQuality of dife(QOL)の関連性の検討

    日本衛生学雑誌   58   269 - 275  2003

  • 2003年度

       2003

  • The Effect of Chronic Stress on Neutrophil Function in Tumor-Inoculatied Rats

    NISHIO Naomi, FUJIOKA Yosei, MIDORIKAWA Taishi, ISHIZAKI Kaori, MACHIDA Kazuhiko

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)   57 ( 4 ) 655 - 660  2003

    　View Summary

    Objectives: In order to clarify the relation between stress load and inoculated tumor growth in conjunction with neutrophil functions, several kinds of stress such as physical (Ph) and psychological (Ps) stress were loaded on rats either SST-2 tumor cell inoculated or control, and the functions of their peripheral neutrophils were determined.<br>Methods: A communication box was used for stress load on rats. SST-2 cells were inoculated in to rats in the tumor-inoculation groups. Two weeks after inoculation, the tumors were removed from the backs of the rats and weighed. The functions of neutrophils in the peripheral blood collected from the tail vein, were determined by the NBT deoxidization method.<br>Results: Tumor growth was enhanced when rats were loaded with either Ph or Ps stresses, but was inhibited when tumor cells were inoculated following either Ph or Ps stresses. These results show that chronological differences of loaded stresses influence immunological functions differently. The O2- production from the neutrophils stimulated by NBT-treated Staphilococcus aureus was suppressed in tumor-inoculated Ph and Ps groups, more markedly in the tumor-inoculated Ph group. It is logically relevant that the size of tumors increased in these groups, predominantly in the tumor-inoculated Ph group. On the other hand, O2- production from the neutrophils was enhanced and tumor growth decreased in tumor-inoculated animals following either Ph or Ps stresses.<br>Conclusions: Our experiments, it revealed that the function of neutrophils is strongly enhanced by stress load and O2- production is inhibited by the tumor inoculation as shown in stimulation tests. Therefore, our findings suggested that neutrophils may participate in the inhibition of tumor growth.

    DOI PubMed CiNii

  • 在宅高齢者の家族形態とライフスタイル

    日本衛生学雑誌   58(1) ( 1 ) 640  2003

  • 高齢者の生体防御機能判定におけるフローサイトメトリー法の利用

    平成11年度～13年度日本学術審議会科学研究補助金 基盤研究（C)(1) 研究成果報告書    2003

  • 高齢者の生活習慣と口腔保健状況に関する調査研究（5）

    日本衛生学雑誌   58(1) ( 1 ) 640  2003

  • 高齢者における医療行動と免疫能力の関係

    日本衛生学雑誌   58(1) ( 1 ) 218  2003

  • 激運動時の血中サイトカインバランスの変動と機序

    日本衛生学雑誌   58(1) ( 1 ) 609  2003

  • 加齢および自発運動が免疫能に与える影響

    日本衛生学雑誌   58(1) ( 1 ) 215  2003

  • SST-2 tumor inoculation is a useful model for studying the anti-tumor immune response in SHR rats

    Naomi Nishio, Katsutaka Oishi, Kazuhiko Machida

    Environmental Health and Preventive Medicine   8 ( 1 ) 1 - 5  2003

    　View Summary

    Objective: The purpose of the present study was to investigate the relation between the dose of tumor cell inoculation (especially the doses less than minimum required to evoke tumor growth) and the anti-tumor immune system, particularly lymphoblast formation and cytotoxic activity of lymphcytes. Method: We inoculated rats with various doses of SST-2 tumor cells and examined natural killer (NK) cell activity and lymphoblast formation in vitro. Result: The results showed that the cytotoxicities against SST-2 cells and lymphoblast formation of lymphocytes were enhanced by small dose inoculation of tumor cells that could not induce tumor growth. Conclusion: It was suggested that was lymphocutes play an important role as an anti-tumor immune system at small doses of tumor inoculation, which appears to reflect an early stage of tumor growth in vivo. It was also suggested that SST-2 tumor inoculation might be a useful model for studying the anti-tumor immune response in SHR rats.

    DOI CiNii

  • 忍び寄る感染症ーSARSについて

    町田和彦

    CAMPUS NOW   2003 ( 7 )  2003

  • The Relationship of Quality of Life (QOL) with Physical Fitness, Competence and Stress Response in Elderly in Japan

    UEMURA Shinichi, MACHIDA Kazuhiki

    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)   58 ( 3 ) 369 - 375  2003

    　View Summary

    Objectives: In order to evaluate the relationship of quality of life (QOL) with physical fitness, competence and stress response in the elderly population in Japan, a cross sectional field survey of elderly subjects was conducted.<br>Methods: This survey was taken in Naguri village, Saitama. The data collected included physical fitness, competence, stress response and QOL in addition to demographic variables. As for physicl fitness indexes, grip strength (GS), single leg balance with eyes closed (SLB), bar grip ping reaction time (RT), trunk flexion (RF), ten-meter walking time (WT) and vital capacity (VC) were measured. The SF-36 was used for QOL assessment.<br>Results: A total of 120 elderly subjected participated to the survey. There were 42 males (73.5±5.74 years) and 78 females (74.2±6.17 years). The associations between physical health parameters in SF-36 and WT were highly significant: physicl functioning (β=-2.96, p<0.001), role physical (β=-3.64, p<0.001), bodily pain (β=-3.27, p<0.001) and general health (β=-3.14, p=0.001). Psychological stress response had a negative correlation with social functioning (β=-0.74, p=0.024), role-emotional (β=-2.34, p<0.007) and mental health (β=-0.97, p=0.024) as determined by multiple regression analysis. The goodness-of-fit indexes of the structural equation model describing the relationships among physical fitness, competence, stress response and QOL indicated excellent fit to the data with GFI=0.95 and AGFI=0.88. Stress response showed relatively stronger influence on QOL than physical fitness or competence.<br>Conclusion: Although there were slight differences in degree of influence, physical fitness, stress response and competence were found to be clearly related to QOL in elderly subjects. To keep good QOL status, it is important to maintain good physical fitness and level of competence and to reduce stress response.

    DOI PubMed CiNii

  • 人間教育としての芸術の役割

    町田和彦

    中等教育資料（文部科学省編集）   ( 809 ) 10 - 13  2003

  • 健康医療福祉学：佐久間淳編著、佐久間充、園田洋一著（2003） A5,202頁、大修館書店（東京）

    町田和彦

    民族衛生   69 ( 6 ) 233  2003

  • 人間を町田和彦トータルでみた予防医学

    町田和彦

    Good Professor(早稲田塾ドットコム）   ( 12 ) 1 - 3  2003

  • Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/p70

    K Suzuki, S Nakaji, S Kurakake, M Totsuka, K Sato, T Kuriyama, H Fujimoto, K Shibusawa, K Machida, K Sugawara

    EXERCISE IMMUNOLOGY REVIEW   9 ( 9 ) 48 - 57  2003

    　View Summary

    It is known that interleukin (IL)-12 p70 promotes the differentiation of type-1 helper T (Th1) cells, which produce type-1 cytokines such as IL-2 and interferon (IFN), thereby supporting cellular immunity, whereas IL-12 p40 acts as an antagonist of IL-12 p70. In contrast, IL-4 and IL-6 promote the differentiation of Th2 cells, which produce type-2 cytokines IL-4, IL-6 and IL-10, induce humoral immunity and are involved in allergic reactions. Exhaustive exercise causes the suppression of T lymphocyte activity while asthmatic and allergic diseases are subclinically more prevalent in athletes. One of the mechanisms behind these observations might be a lower type-1 and higher type-2 cytokine balance, which we previously demonstrated to occur after exhaustive exercise. In the present study, we investigated the type-1/type-2 cytokine balance by measuring plasma concentrations of IL-2, IL-4, IL-5, IL-10, tumor necrosis factor (TNF)-alpha and IFN-gamma with microparticle-based flow cytometric technology. IL-5, IL-6 and IL-13 were measured by enzyme-linked immunosorbent assay (ELISA). IL-12 p40 and p70 were measured separately, also by ELISA. Plasma IL-12 p40 concentration rose significantly after maximal exercise and to an even greater extent after a marathon race. Conversely, plasma IL-12 p70 could not be detected even using two different assays. The marathon race caused a marked increase in the plasma concentrations of IL-6 and IL-10. Their responses were correlated (r=0.78, p&lt;0.01), indicating that IL-6 is an inducer of IL-10, and may partly induce the type-1 &lt; type-2 cytokine balance. With the exception of one study involving maximal exercise, other studies have failed to show any change in circulating IL-12 concentration with exercise. The present study demonstrated that IL-12 p40 was present in excess of p70 especially after exercise. This may be one of the mechanisms behind several phenomena including cellular immunosuppression, an increase in the relative proportion of type-2 cytokines following exhaustive exercise, and the higher incidence of infections and allergic disorders in regularly exercising endurance athletes.

  • SSt-2 tumor inculation is a useful model for studying the anti-tumor immune respose in SHR rats

    N.Nishio, K.Oishi, K.Machida

    Envion.Health prevent.   8 ( 1 ) 1 - 5  2003

    DOI CiNii

  • 渡良瀬川、利根川、江戸川流域での河川水および水道水の水質に関する追跡研究（中間報告）（調査報告）

    2002年度日本学術会議第6回水資源に関するシンポジューム論文集    2002

  • 渡良瀬川、利根川、江戸川流域での河川水および水道水の水質に関する追跡研究（中間報告）

    2002年度日本学術会議 第6回水資源に関するシンポジューム論文集    2002

  • 腫瘍細胞接種ラットのリンパ球サブセットに及ぼすスピルリナの影響

    体力栄養免疫学雑誌   12 ( 1 ) 3 - 9  2002

  • 高齢者の自覚的ストレスが好中球機能に及ぼす影響

    体力栄養免疫学雑誌   12 ( 2 ) 162 - 163  2002

  • 高齢者の居住地域と家族形態が健康に及ぼす影響

    体力栄養免疫学雑誌   12 ( 2 ) 156 - 157  2002

  • 高齢者における健康調査および口腔検査

    体力栄養免疫学雑誌   12 ( 2 ) 160 - 161  2002

  • 高齢者における1日歩行数調査

    体力栄養免疫学雑誌   12 ( 2 ) 158 - 159  2002

  • 2002年度

       2002

  • Different effects of immobilization stress on the mRNA expression of antioxidant enzymes in rat peripheral organs

    Scand J Clin Lab Invest   62   115 - 122  2002

    DOI

  • 渡良瀬川・利根川・江戸川流域での河川水および水道水の水質に関する追跡研究

    日本衛生学雑誌   57 ( 1 ) 240  2002

  • 高齢者の生活習慣と口腔保健状況に関する調査研究〔4〕

    日本衛生学雑誌   57(1) ( 1 ) 307  2002

  • 高齢者の生活習慣と口腔保健に関する調査研究（5）

    日本衛生学雑誌   57(1) ( 1 ) 308  2002

  • 高齢者の医療行動:検診参加者と非参加者との比較

    日本衛生学雑誌   57 ( 1 ) 364  2002

  • 高齢者のライフスタイルが生体諸機能に及ぼす影響（2）運動習慣

    日本衛生学雑誌   57 ( 1 ) 363  2002

  • 高齢者mのライフスタイルが生体諸機能に及ぼす影響（1）食生活

    日本衛生学雑誌   57 ( 1 ) 362  2002

  • 加齢に伴う好中球貪食・殺菌能の衰退とライフスタイルに関する研究

    日本衛生学雑誌   57 ( 1 ) 230  2002

  • 加齢による生体防御機能の変化とライフスタイルに関する研究 ２：ストレスと非特異免疫

    日本衛生学雑誌   57 ( 1 ) 413  2002

  • 加齢による生体防御機能の変化とライフスタイルに関する研究 １：自由運動と非特異免疫能

    日本衛生学雑誌   57 ( 1 ) 415  2002

  • 加齢による生体機能の変化とライフスタイルに関する研究 ３：摂餌制限と非特異免疫

    日本衛生学雑誌   57 ( 1 ) 414  2002

  • ラットにおける加齢とライフスタイルが生体内微量元素に及ぼす影響

    日本衛生学雑誌   57 ( 1 ) 273  2002

  • 巻頭言：健康・福祉・医療政策ー人間科学の立場から

    町田和彦

    民族衛生   68 ( 3 ) 75 - 76  2002

    DOI CiNii

  • 日常生活習慣と唾液中IgA抗体量についいて－２－

    第５６回日本栄養・食糧学会大会講演要旨集     347  2002

  • 食生活が免疫能に及ぼす影響

    日本公衆衛生学雑誌   49 ( 10 ) 596  2002

  • ストレスが好中球機能に及ぼす影響

    日本公衆衛生学雑誌   49 ( 10 ) 542  2002

  • 特集 運動は免疫能を高めるか？ メカニズムをさぐる Ⅲ 好中球

    町田和彦

    臨床スポーツ医学   19 ( 11 ) 1303 - 1309  2002

  • 運動療法の新しい取り組みーそのメカニズムと有用性についてー

    治療   84 ( 12 ) 165 - 169  2002

  • Relationships between lifestyle factors and neutrophil functions in the elderly

    K Tsukamoto, K Suzuki, K Machida, C Saiki, R Murayama, M Sugita

    JOURNAL OF CLINICAL LABORATORY ANALYSIS   16 ( 5 ) 266 - 272  2002

    　View Summary

    We investigated the relationships between neutrophil functions and lifestyle factors in the elderly. The subjects (84 males, 73.9+/-5.8 years old; and 63 females, 70.0+/-4.6 years old) belonged to a recreational seniors club in Japan. Investigations of the subjects' stress, exercise habits, smoking habits, and alcohol-drinking habits were performed. The phagocytosis and superoxide productivity of the neutrophils were measured with a nitroblue tetrazolium (NBT) reduction test. In addition, leukocyte counts and serum total protein (TP) levels were determined. The results revealed that aging, high serum levels, and stress-coping factors (e.g., having hobbies, keeping pets, and close links with friends or family) significantly correlated with preferable neutrophil functions. In addition, significant effects of lifestyle factors on the balance between phagocytosis and subsequent superoxide production were observed. Thus, the results of the present study suggest that there are correlations between neutrophil functions and lifestyle factors in the elderly. (C) 2002 Wiley-Liss, Inc.

    DOI

  • Different effects of immobilization stress on the mRNA expression of antioxidant enzymes in rat peripheral organs

    Scand J Clin Lab Invest   62   115 - 122  2002

    DOI

  • 腫瘍細胞の進展にともなう非特異免疫の変化に及ぼす運動とストレスの影響(調査報告)

    平成10-12年度科学研究費補助金基盤研究(C)(2)研究成果報告書    2001

  • 高齢者のライフスタイルと歯周疾患との関係

    日本歯科医療管理学会   36 ( 3 )  2001

  • Time-related changes in splenic immunocyte population in mice after a subcutaneous injection of beryllium

    T Sakaguchi, S Sakaguchi, Y Ina, K Machida

    TRACE ELEMENTS AND ELECTROLYTES   18 ( 3 ) 107 - 111  2001

    　View Summary

    Objective: We studied time-related changes in splenic immunocyte population in mice after a subcutaneous injection of beryllium (Be). Material and methods: We analyzed cell populations in spleen of mice, which was injected with 50 mug of Be by a flow-cytometric assay. Results: The percentage of lymphoid cells decreased and the percentages of granulocyte-like cells and macrophage-like cells increased in the mice at the 3rd day after injection (the Be-3 group). Then, the percentages of the CD4-positive cells and the CD8-positive cells were significantly lower and the percentage of the B cells was significantly higher in the Be-3 group than in the untreated mice (the Cent group). Conclusion: The rate of CD4- and CD8-positive cells to B cells in the Be-3 group was significantly lower than that in the Cent group. Tn our previous paper, we reported that Be promoted the complement and coagulant system at 3 days after injection. These findings suggested that the activity of cellular immunity was suppressed and that of humoral immunity was enhanced at the 3rd day after the Be injection.

  • Time-related changes in splenic immunocyte population in mice after a subcutaneous injection of beryllium

    T Sakaguchi, S Sakaguchi, Y Ina, K Machida

    TRACE ELEMENTS AND ELECTROLYTES   18 ( 3 ) 107 - 111  2001

    　View Summary

    Objective: We studied time-related changes in splenic immunocyte population in mice after a subcutaneous injection of beryllium (Be). Material and methods: We analyzed cell populations in spleen of mice, which was injected with 50 mug of Be by a flow-cytometric assay. Results: The percentage of lymphoid cells decreased and the percentages of granulocyte-like cells and macrophage-like cells increased in the mice at the 3rd day after injection (the Be-3 group). Then, the percentages of the CD4-positive cells and the CD8-positive cells were significantly lower and the percentage of the B cells was significantly higher in the Be-3 group than in the untreated mice (the Cent group). Conclusion: The rate of CD4- and CD8-positive cells to B cells in the Be-3 group was significantly lower than that in the Cent group. Tn our previous paper, we reported that Be promoted the complement and coagulant system at 3 days after injection. These findings suggested that the activity of cellular immunity was suppressed and that of humoral immunity was enhanced at the 3rd day after the Be injection.

  • Different effects of immobilization stress on the mRNA expression of antioxidant enzymes in rat peripheral organs

    K.Oishi, K.Machida

    Scan.J.Clin.Lab.Invest   62   115 - 122  2001

    DOI

  • Chronic effect of training on neutrophil functions in human

    K.Tsukamoto, K.Suzuki, K.Machida

    Environmental Health and Preventive Medicine   6 ( 1 ) 22 - 26  2001

    DOI CiNii

  • 巻頭インタビュー：今世紀も感染症との戦いはつづく

    月刊 医事研究   30 ( 1 ) 6 - 9  2001

  • 内分泌攪乱化学物質とグルココルチコイドのＭＣ3T3-Ｅ1細胞増殖に及ぼす影響

    日本衛生学雑誌   56 ( 1 ) 402  2001

  • 地域高齢者のQOLとその関連要因の検討

    日本衛生学雑誌   56 ( 1 ) 412  2001

  • 腫瘍接種らｘ夙に及ぼす機能性食品の影響(２)非特異的生体防御機能

    日本衛生学雑誌   56 ( 1 ) 373  2001

  • 腫瘍細胞摂取ラットにおける好中球機能の変化

    日本衛生学雑誌   56 ( 1 ) 235  2001

  • 腫瘍細胞接種ラットに及ぼす機能性食品の影響 (１)リンパ球を中心とした白血球機能

    日本衛生学雑誌   56 ( 1 ) 372  2001

  • 腫瘍細胞接種ラットに及ぼす機能性食品の影響(3)ミネラル、微量元素と健康

    日本衛生学雑誌   56 ( 1 ) 374  2001

  • 腫瘍細胞の進展にともなう非特異免疫の変化に及ぼす運動とストレスの影響

    平成10-12年度科学研究費補助金基盤研究(Ｃ)（２）研究成果報告書    2001

  • 高齢者の生活習慣と口腔保健状況に関する調査研究(３)

    日本衛生学雑誌   56 ( 1 ) 165  2001

  • 高齢者の生活習慣と口腔保健状況に関する調査研究(２)

    日本衛生学雑誌   56 ( 1 ) 164  2001

  • 運動と花粉症-運動部員とその他の学生との比較-

    日本衛生学雑誌   56 ( 1 ) 133  2001

  • Flow Cytometry法を用いた好中球の貪食・殺菌能の測定と評価

    日本衛生学雑誌   56 ( 1 ) 351  2001

  • 日常生活習慣と唾液中IgA抗体量について

    第55回日本栄養・食糧学会大会講演要旨集     249  2001

  • 快適なスポーツライフを-適度な運動で防衛体力向上-

    松戸市民スポーツ情報誌 アゴラ   第14号  2001

  • ”健康の女神”ハイジア”

    東京都立保健科学大学報 ざ・へるすさいえんす   第13号  2001

  • 第1回体力・栄養・免疫学会賞

       2001

  • 高齢者の肥満度と生活諸機能

    体力栄養免疫学雑誌   11 ( 2 ) A73-74  2001

  • 高齢者のストレスとその関連要因の検討

    体力栄養免疫学雑誌   11 ( 2 ) A71-72  2001

  • 各種ライフスタイルと生体防御機能に関する研究 自由運動と非特異免疫能

    体力栄養免疫学雑誌   11 ( 2 ) A25-26  2001

  • 各種ライフスタイルと生体防御機能に関する研究 ３：摂餌制限と非特異免疫

    体力栄養免疫学雑誌   11 ( 2 ) A29-30  2001

  • 各種ライフスタイルと生体防御機能に関する研究 ２：ストレスと非特異免疫能

    体力栄養免疫学雑誌   11 ( 2 ) A27-28  2001

  • 河川水と水道水との関係性に関する研究成果

    体力栄養免疫学雑誌   11 ( 2 ) A69-70  2001

  • ラットにおけるライフスタイルが生体内微量元素に及ぼす影響

    体力栄養免疫学雑誌   11 ( 2 ) A33-34  2001

  • ライフスタイルの違いが好中球における貪食・殺菌能に及ぼす影響

    体力栄養免疫学雑誌   11 ( 2 ) A31-32  2001

  • フローサイトメトリーによる好中球貪食能・活性酸素産生能の測定に関する検討

    体力栄養免疫学雑誌   11 ( 2 ) A60-61  2001

  • 2001年度

       2001

  • Time-related changes in splenic immunocyte population in mice after a subcutaneous injection of beryllium(共同執筆)

    T.Sakaguchi, S.Sakaguchi, Y.Ina, K.Machida

    Trace Elements and Electrolytes   18 ( 3 ) 107 - 111  2001

  • Time-related changes in splenic immunocyte population in mice after a subcutaneous injection of beryllium

    Trace Elements and Electrolytes   18 ( 3 ) 107 - 111  2001

  • Different effects of immobilization stress on the mRNA expression of antioxidant enzymes in rat peripheral organs

    K.Oishi, K.Machida

    Scan.J.Clin.Lab.Invest   62   115 - 122  2001

    DOI

  • Chronic effect of training on neutrophil functions in humans

    Kazumasa Tsukamoto, Katsuhiko Suzuki, Kazuhiko Machida

    Environmental Health and Preventive Medicine   6 ( 1 ) 22 - 26  2001

    　View Summary

    We performed this study to evaluate the chronic effect of training on neutrophil functions in humans. Twenty-six university students (14 males and 12 females) with a mean age of 19.1±0.8 years were divided into the athlete group and the control group based on answers given to a written questionnaire. The capacity of circulating neutrophils to ingest bacteria (phagocytosis) and to produce superoxide (nitroblue tetrazolium reduction) was measured under resting conditions in the absence of training activities. In addition, we measured hematological and serum biochemical parameters. The present analyses revealed that the frequency of subjective symptoms concerning susceptibility to infections (sum of males and females) was higher in the athlete group than in the control group (p&lt
    0.05). In the investigation of males, hemoglobin and serum protein levels of the athlete group were lower than that of the control group (p&lt
    0.01, p&lt
    0.05, respectively). Although total and differential leukocyte counts, and phagocytic activity of neutrophils were not significantly different between the groups, superoxide productivity of neutrophils in the male athlete group was higher than that in the control group (p&lt
    0.05). Since significant differences were observed in hemoglobin and serum protein levels in the male athletes, the training is considered to have been intense. An increase was noted in the neutrophil superoxide production along with these changes, but no significant difference was observed in the phagocytic activity. Therefore, there is the possibility of superoxide overproduction, which may lead to tissue damage.

    DOI CiNii

  • Pulmonary effects of sodium fluoride aerosol on rats

    XQ Chen, K Machida, K Isizaki, N Nisio, M Ando

    FLUORIDE   33 ( 4 ) 159 - 167  2000.11

    　View Summary

    Five-week-old male Fischer rats were exposed 3 hr per day for either 5 or 10 days to three concentrations of sodium fluoride aerosol (1.11, 3.33, and 10.3 mg F/m(3)). A significant increase in lung weight was observed at the highest concentration. The activity of lactate dehydrogenase (LDH) and total protein concentration in bronchoalveolar lavage (BAL) fluid were also significantly higher in rats exposed to 3.33 and 10.3 mg F/m(3). Neutrophil phagocytic activity in the blood was stimulated by 10-day exposure, and a significant increase in bactericidal activity and superoxide production was observed by exposure to 3.33 mg F/m(3) but not to 40.3 mg F/m(3).

  • フッ素吸入暴露後のフッ素排泄と骨組織中蓄積に関する検討

    国立環境研究所特別研究報告石炭燃焼にともなう大気汚染による健康影響と疾病予防に関する研究   SR-33-2000  2000

  • 2000年度

       2000

  • Commentary on the presentation,"Traumatic Outcomes : The mental health and psycological efects of mass violence,"by Richard Mollica(Psychiatrist, Harvard University).

    K.Machida

        50、87-52,107  2000

  • 地球人口100億の世紀―人類はなぜ増えつづけるのか―

    民族衛生   66 ( 2 ) 104  2000

  • 摂取腫瘍細胞数がラットの生態諸機能に及ぼす影響学雑誌

    日本衛生学雑誌   55 ( 1 ) 214  2000

  • 腫瘍細胞摂取ラットに及ぼす運動の影響（2) 非特異的生態防御機能

    日本衛生学雑誌   55 ( 1 ) 216  2000

  • 腫瘍細胞摂取ラットに及ぼす運動の影響（1）血液細胞

    日本衛生学雑誌   55 ( 1 ) 215  2000

  • 自発運動と拘束ストレス負荷によるラット生態防御機能の変化

    日本衛生学雑誌   55 ( 1 ) 264  2000

  • 学生トライアスリートと生態防御機能 (4)夏合宿の影響

    日本衛生学雑誌   55 ( 1 ) 261  2000

  • ベリリウムおよび銅投与マウスにおける酵素活性などの変動日本衛生学雑誌

    日本衛生学雑誌   55 ( 1 ) 276  2000

  • 「New Publi Managementに関する学際的研究」高齢化社会における予防医学政策

    平成10,11年度文部省科研費 研究分担報告報告書 基盤研究(B)(2)研究代表者田村貞雄     87 - 107  2000

  • ボンシンポジュームについて（概要）Comment to Traumatic outocomes:The Mental Health and Psycological Effects of mass violence by Richard Mollica

    平成10,11年度文部省科研費研究分担報告報告書：基盤研究（B）2）     50 - 52  2000

  • 摂取腫瘍細胞数がラットの生体機能に及ぼす影響

    日本衛生学雑誌   55 ( 1 ) 214  2000

  • 腫瘍細胞接種ラットに及ぼす運動の影響（１）血液細胞

    日本衛生学雑誌   55 ( 1 ) 215  2000

  • 腫瘍細胞接種ラットに及ぼす運動の影響（2）非特異的生体防御機能

    日本衛生学雑誌   55 ( 1 ) 216  2000

  • 自発運動と拘束ストレス負荷による生体防御機能の変化

    日本衛生学雑誌   55 ( 1 ) 264  2000

  • 埼玉県名栗村在住の高齢者の居住形態とライフスタイル

    日本衛生学雑誌   55 ( 1 ) 430  2000

  • 高齢者の生活習慣と口腔保健状況に関する調査研究

    日本衛生学雑誌   55 ( 1 ) 433  2000

  • 学生トライアスリートと生体防御機能（第３報）ＮＫ細胞活性の変化

    日本衛生学雑誌   55 ( 1 ) 260  2000

  • 学生トライアスリートと生体防御機能（第2報）夏季合宿の影響

    日本衛生学雑誌   55 ( 1 ) 261  2000

  • ベリリュウムおよび銅投与マウスにおける酵素活性などの変動

    日本衛生学雑誌   55 ( 1 ) 302  2000

  • 腫瘍細胞接種ラットに及ぼす運動の影響

    体力・栄養・免疫学雑誌   10 ( 2 ) 118 - 119  2000

  • 高齢者の血圧測定における水銀血圧計、自動血圧計（指）および手首血圧計の比較研究

    体力・栄養・免疫学会   10 ( 2 ) 132 - 133  2000

  • 大学時代の運動習慣と中年期の健康ー卒業後の運動習慣による差ー

    日本公衆衛生学雑誌   47 ( 11 ) 230  2000

  • 高齢者の生活の側面が血圧に及ぼす影響

    日本公衆衛生学雑誌   47 ( 11 ) 666  2000

  • Effect of the immobilization stress on manganese superoxide dismutase (Mn-SOD) and copper and zinc SOD (Cu/Zn-SOD) activities in rat peripheral organs

    OISHI K.

    J Phys Fit Nutr Immunol   10 ( 3 ) 165 - 169  2000

    CiNii

  • Effects of the immobilization stress on manganese superoxide dismutase(Mn-SOD)and copper and zinc SOD(Cu/Zn-SOD)activities in rat peripheral organs

    Journal of Physical Fittness,Nutrition and Immunology   10 ( 3 ) 165 - 169  2000

  • Commentary on the presentation,"Traumatic Outcomes : The mental health and psycological efects of mass violence,"by Richard Mollica(Psychiatrist, Harvard University).

    K.Machida

        50、87-52,107  2000

  • ボンシンポジュームについて（概要）Comment to Traumatic outocomes:The Mental Health and Psycological Effects of mass violence by Richard Mollica

    平成10,11年度文部省科研費研究分担報告報告書：基盤研究（B）2）     50 - 52  2000

  • Effects of the immobilization stress on manganese superoxide dismutase(Mn-SOD)and copper and zinc SOD(Cu/Zn-SOD)activities in rat peripheral organs

    K.Oishi, S.Maekawa, M.Yokoi, T.Shiraishi, R.Kondo, C.Sodeyama, T.Kuriyama, K.Machida

    Journal of Physical Fittness, Nutrition and Immunology   10 ( 3 ) 165 - 169  2000

  • Effects of the immobilization stress on manganese superoxide dismutase(Mn-SOD)and copper and zinc SOD(Cu/Zn-SOD)activities in rat peripheral organs

    Journal of Physical Fittness,Nutrition and Immunology   10 ( 3 ) 165 - 169  2000

  • Effects of fluoride aerosol inhalation on mice

    XQ Chen, K Machida, M Ando

    FLUORIDE   32 ( 3 ) 153 - 161  1999.08

    　View Summary

    The effects of fluoride aerosol inhalation on mice were studied using an inhalation chamber. Five-week-old male ICR mice were exposed to airborne fluoride (13.3 mgF/m(3)) 4 hr per day for 10, 20 or 30 days. Significant differences in relative lung weight were observed between the exposed groups and the control. No significant changes were found in relative kidney weight and body weight of the exposed mice. Bone fluoride retention and urinary fluoride excretion increased with exposure time.

  • In vitro bactercocidal activity of peripheral whole blood is enhanced by the immobilization stress in rats

    K.Oishi, R.Kondo, C.Sodeyama, H.Kakazu, K.Machida

    J. Khys. Jit. Huts. Immunol.   9/1,3-6 ( 1 ) 3 - 6  1999

  • In vitro bactercocidal activity of peripheral whole blood is enhanced by the immobilization stress in rats

    K.Oishi, R.Kondo, C.Sodeyama, H.Kakazu, K.Machida

    J. Khys. Jit. Huts. Immunol.   9/1,3-6 ( 1 ) 3 - 6  1999

  • Effects of Fluoride Aersol Inhalation on mice

    Xue-Qing Chen, K.Machida, M.Ando

    Fluoride   32 ( 3 ) 153 - 161  1999

  • 高齢化社会における予防医学政策(New Public Managementに関する学際的研究-政府と市場の共生メカニズム : 熱海市の介護保険制度実施に向けての準備と問題点、高齢化社会における予防医学政策)(調査報告)

    早稲田大学共生研究会   4/,49-57  1999

  • Changees of physiological functions in rats induced by melatonin administration and voluntary exercise

    J.Phys.Fitt.Nutr.Immunol.   9;2,109-115  1999

  • 1999年度

       1999

  • Oxidative stress and haemalological changes in immobilized rats

    K.Oishi, M.Yokoi, S.Maekawa, C.Sodeyama, T.Shiraisi, R.Kondo, T.Kuriyama, K.Machida

    Acta. Physiol. Scand.   165/,65-69  1999

    DOI

  • In vitro bacteriocydal activity of peripheral whole blood is enhanced by immobilization stress in rats

    J.Phys. Fitt. Nutr. Immunol.   9;1,3-6  1999

  • In vitro bactercocidal activity of peripheral whole blood is enhanced by the immobilization stress in rats

    K.Oishi, R.Kondo, C.Sodeyama, H.Kakazu, K.Machida

    J. Khys. Jit. Huts. Immunol.   9/1,3-6  1999

  • Effects of fluoride aerosol inhalation on mice

    Fluoride   32;3,153-161  1999

  • Effects of Fluoride Aersol Inhalation on mice

    Xue-Qing Chen, K.Machida, M.Ando

    Fluoride   32/3  1999

  • Changes of physiological functions in rats induced by melatonin administration and voluntary exercial

    T.Kuriyama, S.Fukatani, H.Kakazu, K.Konishi, K.Ishizaki, N.Nishio, K.Machida

    J. Phys. Fit. Nutr. Immunol.   9/2,109-115  1999

  • Oxidative stress and haematologlcal changes in immobilized rats

    Acta Physiol. Scand.   165,65-69  1999

    DOI

  • 腫瘍細胞接種ラットに及ぼすストレスの影響（2）非特異的生体防御機能

    日本衛生学雑誌   54;1,p384  1999

  • 腫瘍細胞接種ラットに及ぼすストレスの影響（1）生体諸機能

    日本衛生学雑誌   54;1,p383  1999

  • 高齢者のライフスタイルと身心の健康に関する調査研究（3）5年間の歩み

    日本衛生学雑誌   54;1,p342  1999

  • 高齢者における身体活動量と健康の関係

    日本衛生学雑誌   54;1,p278  1999

  • 荒記俊一編「交通安全と健康」杏林書院，1998

    民族衛生   65-2,p125  1999

  • 学生トライアスリートと生態防御機能（3）NK細胞活性の変化

    日本衛生学雑誌   55;1,260  1999

  • 学生トライアスリートと生体防御機能（第2報）夏期合宿の影響

    日本衛生学雑誌   54;1,p277  1999

  • 学生トライアスリートと生体防御機能（第1報）試合前後の変化

    日本衛生学雑誌   54;1,p276  1999

  • 運動習慣が高齢者の生化学検査に及ぼす影響

    日本衛生学雑誌   54;1,p279  1999

  • メタルチオネイン誘導ストレス負荷による免疫応答の増強

    日本衛生学雑誌   54;1,p385  1999

  • ベリリウム投与マウスにおける免疫細胞比率の変動

    日本衛生学雑誌   54;1,p182  1999

  • ベリリウム投与マウスにおける血清脂質の変動

    日本衛生学雑誌   54;1,p181  1999

  • 特別寄稿：何か起こるのでは・・・

    町田和彦

    林遊(中高年の交流誌）   1;1、14-15  1999

  • 高齢化社会における予防医学政策（New Public Managementに関する学際的研究－政府と市場の共生メカニズム：熱海市の介護保険制度実施に向けての準備と問題点、高齢化社会における予防医学政策

    早稲田大学共生研究会   4、49-57  1999

  • 水道水中有機汚染物質と原水との関係

    公衆衛生雑誌   46;10,751  1999

  • ベリリウム投与マウスにおける脾細胞亜集団比率の変動

    公衆衛生雑誌   46;10,749  1999

  • Oxidative stress and haemalological changes in immobilized rats

    K.Oishi, M.Yokoi, S.Maekawa, C.Sodeyama, T.Shiraisi, R.Kondo, T.Kuriyama, K.Machida

    Acta. Physiol. Scand.   165/,65-69  1999

    DOI

  • In vitro bacteriocydal activity of peripheral whole blood is enhanced by immobilization stress in rats

    J.Phys. Fitt. Nutr. Immunol.   9;1,3-6  1999

  • In vitro bactercocidal activity of peripheral whole blood is enhanced by the immobilization stress in rats

    K.Oishi, R.Kondo, C.Sodeyama, H.Kakazu, K.Machida

    J. Khys. Jit. Huts. Immunol.   9/1,3-6  1999

  • Effects of fluoride aerosol inhalation on mice

    Fluoride   32;3,153-161  1999

  • Effects of Fluoride Aersol Inhalation on mice

    Xue-Qing Chen, K.Machida, M.Ando

    Fluoride   32/3  1999

  • Changes of physiological functions in rats induced by melatonin administration and voluntary exercial

    T.Kuriyama, S.Fukatani, H.Kakazu, K.Konishi, K.Ishizaki, N.Nishio, K.Machida

    J. Phys. Fit. Nutr. Immunol.   9/2,109-115  1999

  • Oxidative stress and haematologlcal changes in immobilized rats

    Acta Physiol. Scand.   165,65-69  1999

    DOI

  • ベリリウムの免疫系に及ぼす影響

    体力・栄養・免疫学雑誌   8 ( 2 ) 168 - 173  1998

  • Phagocytic function of circulating neutrophils may be Influenced by seruｍ lipids and apoproteins in exercised and sedentary rats

    J. Phys. Fit. Nutr. Immunol.   8 ( 1 ) 63 - 65  1998

  • Phagocytic function of circulating neutrophils may be Influenced by seruｍ lipids and apoproteins in exercised and sedentary rats

    J. Phys. Fit. Nutr. Immunol.   8 ( 1 ) 63 - 65  1998

  • ベリリウムの免疫系に及ぼす影響

    体力・栄養・免疫学雑誌   8/2,168-173  1998

  • Phagocytic function of circulating neutrophils may he serum lipids and apolipoproteins in exercised and redentary rats

    J. Phys. Fit. Nutr. Immunol.   8/1,63-65  1998

  • Phagocytic function of circulating neutrophils may be Influenced by seruｍ lipids and apoproteins in exercised and sedentary rats

    J. Phys. Fit. Nutr. Immunol.   8l1,63-65  1998

  • 拘束ストレスによるラット生体内諸機能の変動

    日本衛生学雑誌   52:4、647-653  1998

    DOI

  • 都内各水源中汚染物質と水道水との関係

    日本衛生学雑誌   53:1  1998

  • 身体的ストレスおよび心理的ストレスがラットの非特異免疫能に及ぼす影響

    日本衛生学雑誌   53:1  1998

  • 高齢者の運動習慣が体力と健康に及ぼす影響

    日本衛生学雑誌   53:1  1998

  • 高齢者のライフスタイルが非特異免疫に及ぼす影響

    日本衛生学雑誌   53:1  1998

  • ベリリュウム投与２世代マウスの酵素活性に及ぼすベリリュウムの影響

    日本衛生学雑誌   53:1  1998

  • フッ素暴露影響のカルシュウムによる修飾

    日本衛生学雑誌   53:1  1998

  • 新簡明衛生公衆衛生 第4版

    南山堂    1998

  • 平成8年度，9年度文部省科学研究費補助金（基礎研究C）研究成果報告書（代表者：町田和彦）「非特異免疫能に及ぼす各種ストレスの影響」

      p1-51(+2論文)  1998

  • 上田礼子著「発達のダイナミクスと地域性」ミネルヴァ書房，

    1998   民族衛生 64/4,278-279  1998

  • (KEY PERSON) 体育会OBに告ぐ

    Training Journal   8月号,p3  1998

  • Effects of inhaled fuluorlde on mice

    Int. Soc. Fruoride Res. Prog. Abst. Book   p70  1998

  • Effects of inhaled fuluoride on mice

    Int. Soc Fluoride Res.Prog.Abst Book     70  1998

  • 通常練習と合宿練習時の生化学検査値の比較

    体力・栄養免疫学雑誌   8;2,209-211  1998

  • 狭山市在住の高齢者のライフスタイルに関する研究

    体力・栄養免疫学雑誌   8;2,174-175  1998

  • ラットの皮下移植腫瘍がナチュラルキラー細胞活性に及ぼす影響

    体力・栄養免疫学雑誌   8;2,153-154  1998

  • ペリリウムの免疫系に及ぼす影響

    体力・栄養免疫学雑誌   8;2,168-173  1998

  • トライアスロン競技大会前後の生化学検査値の変動

    体力・栄養免疫学雑誌   8;2,206-208  1998

  • （会長講演）大学時代の運動と熟年期のライフスタイルと健康

    体力・栄養免疫学雑誌   8;2,147-149  1998

  • Phagocytic function of circulating neutrophils may he serum lipids and apolipoproteins in exercised and redentary rats

    J. Phys. Fit. Nutr. Immunol.   8/1,63-65  1998

  • Phagocytic function of circulating neutrophils may be Influenced by seruｍ lipids and apoproteins in exercised and sedentary rats

    J. Phys. Fit. Nutr. Immunol.   8l1,63-65  1998

  • Effects of inhaled fuluorlde on mice

    Int. Soc. Fruoride Res. Prog. Abst. Book   p70  1998

  • Effects of inhaled fuluoride on mice

    Int. Soc Fluoride Res.Prog.Abst Book     70  1998

  • 急性拘束ストレスにおけるラットMφのNO審生能と殺菌能

    体力・栄養免疫学雑誌   7 ( 1 ) 21 - 34  1997

  • Some plasma component is essential for IL-6 secretion by neutrophils

    Katsutaka Oishi, Kazuhiko Machida

    Environmental Health and Preventive Medicine   2 ( 2 ) 89 - 92  1997

    　View Summary

    Recently, the neutrophil has been shown to have the capacity to produce a number of cytokines. Among these cytokines, interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and IL-6 are typical examples of multifunctional cytokines involved in regulation of the immune response and inflammation. However, there are conflicting reports in the literature concerning the issue of whether IL-6 expression can be modulated in human neutrophils. In this study, we showed the spontaneous secretion of IL-1β, TNF-α and IL-6 by neutrophils. IL-6 secretion of neutrophils was effectively induced by IL- 1β. However, spontaneous or IL-1β induced secretion of IL-6 was observed only when the cells were cultured in autologous plasma. Then we examined the spontaneous secretion of cytokines by co-cultured leukocytes (neutrophils, monocytes, and lymphocytes). Surprisingly, IL-6 was dramatically secreted by the leukocytes only when the cells were cultured in autologous plasma, although IL-1β and TNF- α were secreted by the cells either in RPMI 1640 or in plasma. These observations suggest that the regulation of IL-6 production is qualitatively different from the production of IL-1β or TNF- α by leukocytes.

    DOI

  • Seasonal changes of serum opsonic activity in health male adults

    KUMAE T.

    J.Phys.Fit.Nutr.Immunol.   7 ( 1 ) 3 - 12  1997

    CiNii

  • Seasonal Changes of Serum Opsonic Activity in Healthy Male Adults

    J.Phys.Fit.Nutr.Immunol.   7 ( 1 ) 3 - 12  1997

  • Some Plasma Components is Essential for IL-6 Secretion by Neutrophils

    Environ.Health Prevent.Med   2 ( 2 ) 89 - 92  1997

  • Some plasma component is essential for IL-6 secretion by neutrophils

    Environ, Health Prevent. Med.   2 ( 2 ) 89 - 92  1997

  • Seasonal Changes of Serum Opsonic Activity in Healthy Male Adults

    J.Phys.Fit.Nutr.Immunol.   7 ( 1 ) 3 - 12  1997

  • Some Plasma Components is Essential for IL-6 Secretion by Neutrophils

    Environ.Health Prevent.Med   2 ( 2 ) 89 - 92  1997

  • Inhibition of neutrophyl apoptosis by antioxidantsu in culture medium

    Scand. J. Immunol.   45   21 - 27  1997

  • Inhibition of neutrophyl apoptosis by antioxidantsu in culture medium

    Scand. J. Immunol.   45   21 - 27  1997

  • 急性拘束ストレスにおけるラットMφのNO審生能と殺菌能

    体力・栄養免疫学雑誌   7/1,21-34  1997

  • Some plasma component is essential for IL-6 secretion by neutrophils

    Environ, Health Prevent. Med.   2/2,89-92  1997

  • Seasonal Changes of Serum Opsonic Activity in Healthy Male Adults

    J.Phys.Fit.Nutr.Immunol.   7:1,3-12  1997

  • Inhibition of neutrophyl apoptosis by antioxidantsu in culture medium

    Scand. J. Immunol.   45/,21-27  1997

  • Inhibition of Apoptosis by antioxidants in culture medium

    Scandinavian journal of Immunology   45,21-27  1997

  • ライフスタイルと健康－人生80年時代を有意義に過ごすために

    からだ・こころ・つながりの発達研究ディベロップメント   7  1997

  • 明暗の変化がラットの生体防御機能に及ぼす影響（第一報）免疫機能を中心として

    日本衛生学雑誌   52;1  1997

  • 平成８年度 適度な運動と健康教育を中心とした健康増進運動報告書（居住環境別にみたライフスタイルと健康に与える影響）

    狭山市保健センター／早稲田人間科学部衛生学公衆衛生学教室    1997

  • 平成７年度 適度な運動と健康教育を中心とした健康増進運動報告書

    狭山市保健センター／早稲田人間科学部衛生学公衆衛生学教室    1997

  • 渡良瀬川、利根川、江戸川水系の河川の汚染と水道水 第３報：有機化合物

    日本衛生学雑誌   52;1  1997

  • 長期自発運動のラット生体内緒機能に及ぼす影響

    日本衛生学雑誌   52;1  1997

  • 高齢者のライフスタイルと非特異免疫

    日本衛生学雑誌   52;1  1997

  • 高齢者のライフスタイルと心身の健康に関する調査研究（2)

    日本衛生学雑誌   52;1  1997

  • 狭山丘陵周辺における人間生活と水質汚染

    日本衛生学雑誌   52;1  1997

  • 暗延長、明延長がラットの生体内緒機能に及ぼす影響（第2報）血清及び尿中成分に与える

    日本衛生学雑誌   52;1  1997

  • 新簡明衛生公衆衛生 第３版

    南山堂    1997

  • Some Plasma Components is Essential for IL-6 Secretion by Neutrophils

    Environ.Health Prevent.Med   2:2、89-92  1997

  • 非特異免疫能に及ぼす明暗条件の変化

    体力・栄養免疫学会    1997

  • 海外赴任者のライフスタイルと毛髪中元素

    体力・栄養免疫学会    1997

  • メラトニン投与の好中球機能に及ぼす影響

    体力・栄養免疫学会    1997

  • シンポジュウム：スポーツの功罪―スポーツは体に悪い？？― わが国における疫学的成績

    日本臨床スポーツ医学会誌   5:4  1997

  • Some plasma component is essential for IL-6 secretion by neutrophils

    Environ, Health Prevent. Med.   2/2,89-92  1997

  • Seasonal Changes of Serum Opsonic Activity in Healthy Male Adults

    J.Phys.Fit.Nutr.Immunol.   7:1,3-12  1997

  • Inhibition of neutrophyl apoptosis by antioxidantsu in culture medium

    Scand. J. Immunol.   45/,21-27  1997

  • Inhibition of Apoptosis by antioxidants in culture medium

    Scandinavian journal of Immunology   45,21-27  1997

  • Some Plasma Components is Essential for IL-6 Secretion by Neutrophils

    Environ.Health Prevent.Med   2:2、89-92  1997

  • Importance of correlations between phagocytic activity and superoxide production of neutrophils under conditions of voluntary exercise and stress

    T Kuriyama, K Machida, K Suzuki

    JOURNAL OF CLINICAL LABORATORY ANALYSIS   10 ( 6 ) 458 - 464  1996

    　View Summary

    The importance of the neutrophil function to host defense and tissue damage has been widely recognized. However, the usefulness of the correlation analysis between phagocytic activity and superoxide production of neutrophils is unknown. We investigated the relationship by histochemical NET assay using rats and mice exposed to voluntary exercises and stresses.
    The following conclusions were shown from the results in this report and from our previously published findings. The results of voluntary exercise showed significant positive correlations between phagocytic activity and superoxide production of neutrophils after the continuation of the exercise for 8 months, but no relationship after only 3 or 4 months. However, when Salmonella was injected into the same group after 4 months, significant positive correlations were observed immediately following and on the 6th and 14th days after injection. In contrast, negative correlations emerged after psychological stress and severe-crowding stress, suggesting that appropriate expression of neutrophil function was disturbed by the reverse effects, such as by suppression of oxygen-dependent killing capacity or overproduction of toxic free radicals subsequent to these stress.
    These results suggest that the correlations of phagocytic activity and superoxide production of neutrophils reflect whether a neutrophil functional state is appropriate or not. (C) 1996 Wiiey-Liss, Inc.

    DOI

  • 高齢者のライフスタイル・社会的ネットワークと血圧・血清脂質との関係

    日本衛生学雑誌   50 ( 6 ) 1057 - 1066  1996

    DOI

  • ストレスがラット生体内緒機能に及ぼす影響 －身体的ストレスと心理的ストレス-

    体力・栄養免疫学雑誌   6 ( 2 ) 157 - 168  1996

  • Importance of correlations between phagocytic activity and superoxide production of neutrophyls under conditions of voluntary exercise and stress

    J. Clin. Labo. Anal.   10   458 - 464  1996

    DOI

  • Importance of correlations between phagocytic activity and superoxide production of neutrophyls under conditions of voluntary exercise and stress

    J. Clin. Labo. Anal.   10/,458-464   458 - 464  1996

    DOI

  • Importance of correlations between phagocytic activity and superoxide production of neutrophyls under conditions of voluntary exercise and stress

    J. Clin. Labo. Anal.   10/,458-464   458 - 464  1996

    DOI

  • 新簡明衛生公衆衛生 第２版

    南山堂    1996

  • Importance of correlations between phagocytic activity and superoxide production of neutrophyls under conditions of voluntary exercise and stress

    J. Clin. Labo. Anal.   10/,458-464  1996

    DOI

  • 高齢者のライフスタイル・社会的ネットワークと血圧・血清脂質との関係

    日本衛生学雑誌   50;6,1057-1066  1996

    DOI

  • 特異的及び非特異的免疫機能に及ぼすラットの自発運動の影響に関する研究

    文部省科学研究費研究成果報告書    1996

  • 水道水を処理した飲料水とその源水中各種成分の比較研究（II）

    日本衛生学雑誌   51;1  1996

  • 高齢者のライフスタイルと心身の健康に関する研究

    日本衛生学雑誌   51;1  1996

  • 拘束ストレスにおけるラットのＭφのＮＯ産生能

    日本衛生学雑誌   51;1  1996

  • 好酸化酵素による好中球アポトーシスの抑制

    日本衛生学雑誌   51;1  1996

  • ラット拘束ストレス負荷による非特異免疫能の増強

    日本衛生学雑誌   51;1  1996

  • ラット拘束ストレス負荷による赤血球中好酸化機構の変動

    日本衛生学雑誌   51;1  1996

  • ラット拘束ストレス負荷による生態防御機能の変化

    日本衛生学雑誌   51;1  1996

  • 拘束ストレスの好中球機能に及ぼす影響

    体力・栄養免疫学雑誌   6;1  1996

  • 運動と中高年の健康

    早稲田学報   50;9  1996

  • Importance of correlations between phagocytic and superoxide production of nutrophilis under conditions of voluntary exercise and stress

    Jounal of Clinical laboratory analysis   10;6,458-464  1996

    DOI

  • ストレスがラット生体内緒機能に及ぼす影響 －身体的ストレスと心理的ストレス-

    体力・栄養免疫学雑誌   6;2,157-168  1996

  • Importance of correlations between phagocytic activity and superoxide production of neutrophyls under conditions of voluntary exercise and stress

    J. Clin. Labo. Anal.   10/,458-464  1996

    DOI

  • Importance of correlations between phagocytic activity and superoxide production of neutrophils under conditions of voluntary exercise and stress

    Takao Kuriyama, Kazuhiko Machida, Katsuhiko Suzuki

    Journal of Clinical Laboratory Analysis   10 ( 6 ) 458 - 464  1996

    　View Summary

    The importance of the neutrophil function to host defense and tissue damage has been widely recognized. However, the usefulness of the correlation analysis between phagocytic activity and superoxide production of neutrophils is unknown. We investigated the relationship by histochemical NBT assay using rats and mice exposed to voluntary exercises and stresses. The following conclusions were shown from the results in this report and from our previously published findings. The results of voluntary exercise showed significant positive correlations between phagocytic activity and superoxide production of neutrophils after the continuation of the exercise for 8 months, but no relationship after only 3 or 4 months. However, when Salmonella was injected into the same group after 4 months, significant positive correlations were observed immediately following and on the 6th and 14th days after injection. In contrast, negative correlations emerged after psychological stress and severe-crowding stress, suggesting that appropriate expression of neutrophil function was disturbed by the reverse effects, such as by suppression of oxygen-dependent killing capacity or overproduction of toxic free radicals subsequent to these stress. These results suggest that the correlations of phagocytic activity and superoxide production of neutrophils reflect whether a neutrophil functional state is appropriate or not.

    DOI PubMed

  • 適度な運動習慣の感染ラットの生体内諸機能に及ぼす影響

    体力・栄養免疫学雑誌   5 ( 1 ) 52 - 58  1995

  • Effectiveness of lower-level Voluntary exercise in disease prevention of mature rats. 1. cardiovascular risk factor modification

    European Journal of Applied Pysiology   71   240 - 244  1995

  • 適度な運動の感染ラットの生体内緒機能に及ぼす影響

    体力・栄養免疫学雑誌   5 ( 1 ) 52 - 58  1995

  • ラットの自発走及びトレッドミル走の生体諸機能に及ぼす影響

    体力・栄養免疫学雑誌   5 ( 2 ) 99 - 108  1995

  • Effectiveness of lower-level Voluntary exercise in disease prevention of mature rats. 1. cardiovascular risk factor modification

    European Journal of Applied Pysiology   71   240 - 244  1995

  • 水道水を処理した飲料水とその原水中各主成分の比較研究

    日本衛生学雑誌   50;1  1995

  • Effectiveness of lower-level Voluntary exercise in disease prevention of mature rats. 1. cardiovascular risk factor modification

    European Journal of Applied Pysiology   71/,240-244   240 - 244  1995

  • 適度な運動の感染ラットの生体内緒機能に及ぼす影響

    体力・栄養免疫学雑誌   5;1,52-58 ( 1 ) 52 - 58  1995

  • ヒト爪及び頭髪中の金属元素の比較と季節変動

    体力・栄養免疫学雑誌   5 ( 1 ) 31 - 39  1995

  • Effectiveness of lower-level Voluntary exercise in disease prevention of mature rats. 1. cardiovascular risk factor modification

    European Journal of Applied Pysiology   71/,240-244   240 - 244  1995

  • 適度な運動習慣の感染ラットの生体内諸機能に及ぼす影響

    体力・栄養免疫学雑誌   5/1,52-58  1995

  • 体育会系の卒業生は中年期にツケが回る？

    カレント   18  1995

  • Effectiveness of lower-level voluntary exercise in disease prevention of mature rats, 1. Cardiovascular risk factor modification

    Eur. J. Appl. Pｈysiol.   71,240-244  1995

  • Effectiveness of lower-level Voluntary exercise in disease prevention of mature rats. 1. cardiovascular risk factor modification

    European Journal of Applied Pysiology   71/,240-244  1995

  • 高齢者のライフスタイル・社会的ネットワークの血圧・血清脂質への影響

    日本衛生学雑誌   50;1  1995

  • 各種運動形態におけるラット生体内緒機能に及ぼす影響

    日本衛生学雑誌   50;1  1995

  • ラットにおける血清高密度リポ蛋白質の好中球食作用に及ぼす影響

    日本衛生学雑誌   50;1  1995

  • フローサイトメトリーによる好中球貪食能・殺菌能の測定

    日本衛生学雑誌   50;1  1995

  • 適度な運動の感染ラットの生体内緒機能に及ぼす影響

    体力・栄養免疫学雑誌   5;1,52-58  1995

  • 巻頭言

    体力・栄養免疫学雑誌   5;1  1995

  • ヒト爪及び頭髪中の金属元素の比較と季節変動

    体力・栄養免疫学雑誌   5;1,31-39  1995

  • 大学時代の運動と中年期のライフスタイルと健康

    体力科学   44;6  1995

  • ラットの自発走及びトレッドミル走の生体諸機能に及ぼす影響

    体力・栄養免疫学雑誌   5;2,99-108  1995

  • Effectiveness of lower-level voluntary exercise in disease prevention of mature rats, 1. Cardiovascular risk factor modification

    Eur. J. Appl. Pｈysiol.   71,240-244  1995

  • Effectiveness of lower-level Voluntary exercise in disease prevention of mature rats. 1. cardiovascular risk factor modification

    European Journal of Applied Pysiology   71/,240-244  1995

  • 過密環境がマウス免疫能に及ぼす影響

    塚本 和正, 町田 和彦, 稲 恭宏, 栗山 孝雄, 鈴木 克彦, 村山 留美子, 西城 千夏

    日本衛生学雑誌   49 ( 4 ) 827 - 836  1994

    DOI PubMed

  • 過密環境がマウス免疫能に及ぼす影響

    日本衛生学雑誌   49/,827-836  1994

    DOI

  • 運動習慣と疾病予防効果-実験動物の長期的自発運動による研究成果をふまえて-

    ヒューマンサイエンスリサーチ   3/,127-142  1994

  • マウスの過密・孤立飼育が白血球及びその他の血液成分に及ぼす影響

    ヒューマンサイエンス リサーチ   3/ , 143-151  1994

  • Effect of Training on phpical Exercise-induced changesin non-epecific Humoral Immunity

    JPN.J.Rhys, Fit.sports med   43 ( 1 ) 75 - 83  1994

    DOI

  • Analytical data on drinking water avairable in Japan

    Proceeding on Global Symposium on the Sanitary Manitenance of Drinking Water   /,12-23  1994

  • Effect of training on physical exercise-induced changes in non-specific humoral immunity

    Takashi Kumae, Shigeyoshi Kurakake, Kazuhiko Machida, Kazuo Sugawara

    Japanese Journal of Physical Fitness and Sports Medicine   43 ( 1 ) 75 - 83  1994

    　View Summary

    Although it is generally thought that habitual exercise protects an individual from infections, few careful scientific studies have been conducted. To clarify the influences of physical training on non-specific humoral immunity, both serum opsonic activity, which is a more direct indicator for the strength of non-specific humoral immunity to infections, and serum immunoglobulin and complement levels of 18 healthy male volunteers were assayed before and after a 10-week of training as indices of immuno defense. The serum levels of three immunoglobulins (IgG, IgA and IgM) and one complement (C3) were compared prior to and immediately after exercise both before and after training. Paired t-test revealed that before training exercise-induced increases in IgG and C3 were significant and after training increases in IgG, IgA, IgM and C3 were significant. But baseline (prior to exercise) levels of these immunoglobulins and complement were significantly suppressed during the training period. Serum opsonic activity was compared with each other in the same way as serum protein levels. The neutrophilic chemiluminescence Peak Height (PH), which is one of the indicators of serum opsonic activity, was significantly decreased immediately after exercise at the beginning stage of the training. After the training period, serum opsonic activity showed no noteworthy exercise-induced variations and baseline levels were slightly increased during the training period. These findings suggest that resistance and reactivity to the physical stress are improved and the non-specific humoral immunity, self-defense ability against infections, is considered to be improved by the training. © 1994, The Japanese Society of Physical Fitness and Sports Medicine. All rights reserved.

    DOI

  • Analytical data on drinking water avairable in Japan

    Proceeding on Global Symposium on the Sanitary Manitenance of Drinking Water   /,12-23  1994

  • ラット自発運動の生体防御機能に及ぼす影響

    体力科学   42 ( 2 ) 145 - 154  1993

    DOI

  • 過密ストレスのマウス生体防禦機能に及ぼす影響

    体力・栄養免疫学雑誌   3 ( 1 ) 44 - 48  1993

  • 亜鉛欠乏によるT細胞膜表面抗原の変化

    体力・栄養免疫学雑誌   3 ( 1 ) 40 - 43  1993

  • NBT還元試験による食細胞活性酸素産生能の分析・評価法およびその応用法

    体力・栄養免疫学雑誌   3   31 - 39  1993

  • 過密ストレスのマウス生体防禦機能に及ぼす影響

    体力・栄養免疫学雑誌   3/1, 44-48  1993

  • 亜鉛欠乏によるT細胞膜表面抗原の変化

    体力・栄養免疫学雑誌   3/1, 40-43  1993

  • ラット自発運動の生体防御機能に及ぼす影響

    体力科学   42/2,145-154  1993

    DOI

  • NBT還元試験による食細胞活性酸素産生能の分析・評価法およびその応用法

    体力・栄養免疫学雑誌   3/,31-39  1993

  • ラットの自発走運動モデルの基礎的検討および心健康指標に及ぼす影響

    鈴木 克彦, 町田 和彦, 刈屋 美枝子

    日本衛生学雑誌   47 ( 5 ) 939 - 951  1992

    DOI PubMed CiNii

  • 学会発表

       1988

  • Changes in Serum Immunoglobulin Levels and Neutrophilic Phagocytosis After Exercise

    Takashi Kumae, Kazuo Sugawara, Kazuhiko Machida, Akira Shimaoka

    Japanese Journal of Physical Fitness and Sports Medicine   36 ( 2 ) 61 - 71  1987

    　View Summary

    This paper is intended to give the information we need about personal reactivity to transient loads for the object of estimating human physical fitness. For this purpose, both serum immunoglobulin levels and neutrophilic phagocytosis were assayed as indices to self-defense activities. To determine the later described reproducibility of experimental results, two independent experiments were made on two different groups —one consisting of twelve and the other of fourteen male voluntary students of our college— exercised in the playgroud. The serum levels of three immunoglobulins (IgG, IgA and IgM)and two complements (C3 and C4), prior to and immediately after exercise, were compared with each other. They rose without exception after exercise. Paired T-test revealed that in the group of twelve students, rises in IgG, IgA, C 3, α-l-antitrypsin and transferrin were significant at P&lt
    0.1%, 5 %, 5 %, 5 % and 0.1%, and in the group of fourteen rises in IgG, IgA, IgM, C3, C4, α-1-antitrypsin and transferrin were significant at P&lt
    1 %, 0.1%, 1 %, 0.1%, 0.1%, 0.1% and 0.1%, respectively. In the meantime, the neutrophilic phagocytosis (%) was significantly decreased immediately after exercise in both groups (P&lt
    1 % and P&lt
    0.1% respectively). © 1987, The Japanese Society of Physical Fitness and Sports Medicine. All rights reserved.

    DOI

  • Changes in serum immunoglobulium Levels and neutrophilic Phagocytosis after Exercise

    J. Physical Fitness JAPAN   36/2  1987

    DOI

  • Protective effect of zinc against lethality of the irradiated mice

    Junko Matsubara, Kazuhiko Machida

    Environmental Research   41   558 - 567  1986

    DOI

  • Protective effect of zinc against lethality of the irradiated mice

    Junko Matsubara, Kazuhiko Machida

    Environmental Research   41   558 - 567  1986

    DOI

  • Protective effect of zinc against lethality of the irradiated mice

    MATSUBARA J, SHIDA T, ISHIOKA K, EGAWA S, INADA T, MACHIDA K

    Environmental Research   41 ( 2 ) 558 - 567  1986

    DOI PubMed CiNii

  • Protective effect of zinc against lethality of the irradiated mice

    Environmental Research   41 ( 2 ) 558 - 567  1986

    DOI PubMed CiNii

  • Protective effect of zinc against lethality of the irradiated mice

    Environmental Research   41,58-567  1986

    DOI

  • Protective effect of zinc against lethality of the irradiated mice

    Environmental Research   41,58-567  1986

    DOI

  • SIGNIFICANCE OF ELEMENTAL ANALYSIS OF HAIR AS A MEANS OF DETECTING ENVIRONMENTAL-POLLUTION

    J MATSUBARA, K MACHIDA

    ENVIRONMENTAL RESEARCH   38 ( 2 ) 225 - 238  1985

    DOI

  • Significance of elemental analysis of hair as a means of detecting environmental pollution

    Junko Matsubara, Kazuhiko Machida

    Envionmental Research   38 ( 2 ) 225 - 238  1985

    DOI

  • Significance of elemental analysis of hair as a means of detecting environmental pollution

    Envionmental Research    1985

    DOI

  • Significance of elemental analysis of hair as a means of detecting environmental pollution

    Envionmental Research    1985

    DOI

  • Effect of millimolar level of calcium intake on calcium, phosphorus and cadmium content in rats

    Kazuhiko Machida, Junko Matsubara, Kazuo Sugawara

    Nutrition Reports International   29 ( 5 ) 1146 - 1154  1984

  • Effect of millimolar level of calcium intake on calcium, phosphorus and cadmium content in rats

    Kazuhiko Machida, Junko Matsubara, Kazuo Sugawara

    Nutrition Reports International   29 ( 5 ) 1146 - 1154  1984

  • Effect of millimolar level of calcium intake on calcium, phosphorus and cadmium content in rats

    Nutrition Reports International   29/5  1984

  • Effect of millimolar level of calcium intake on calcium, phosphorus and cadmium content in rats

    Nutrition Reports International   29/5  1984

  • Urinary cyclic AMP and GMP in rats given three different concentrations of cadmium in the diet for one year

    Kazuhiko Machida, Kazuo Sugawara, Kuniaki Ishioka

    Toxicology Letters   16   159 - 164  1983

    DOI

  • Urinary cyclic AMP and GMP in rats given three different concentrations of cadmium in the diet for one year

    Kazuhiko Machida, Kazuo Sugawara, Kuniaki Ishioka

    Toxicology Letters   16   159 - 164  1983

    DOI

  • Urinary cyclic AMP and GMP in rats given three different concentrations of cadmium in the diet for one year

    Toxicology Letters   16/1-2  1983

    DOI

  • Urinary cyclic AMP and GMP in rats given three different concentrations of cadmium in the diet for one year

    Toxicology Letters   16/1-2  1983

    DOI

  • Seasonal changes in basal metabolic rate and serum free fattyacid in the antarctic environment

    Kazuo Sugawara, Kazuhiko Machida, Akira Shimaoka, Takashi Kumae, Masao Nishima

    JPN.J.Biometeol   19 ( 1 ) 59 - 69  1982

  • Seasonal changes in basal metabolic rate and serum free fattyacid in the antarctic environment

    Kazuo Sugawara, Kazuhiko Machida, Akira Shimaoka, Takashi Kumae, Masao Nishima

    JPN.J.Biometeol   19 ( 1 ) 59 - 69  1982

  • Seasonal changes in basal metabolic rate and serum free fattyacid in the antarctic environment

    JPN.J.Biometeol   19/1, 59-69  1982

  • Seasonal changes in basal metabolic rate and serum free fattyacid in the antarctic environment

    JPN.J.Biometeol   19/1, 59-69  1982

  • Significance of Hair Analysis Data obtained by INAA in Comparison to Other Analytical Method Including ICP

    Kazuhiko Machida, Hiromitsu Ogata, Junko Matsubara

    Int.Symp.on Trace Anal.Jechno.Analysis.     83 - 85  1981

  • Significance of Hair Analysis Data obtained by INAA in Comparison to Other Analytical Method Including ICP

    Kazuhiko Machida, Hiromitsu Ogata, Junko Matsubara

    Int.Symp.on Trace Anal.Jechno.Analysis.     83 - 85  1981

  • Significance of Hair Analysis Data obtained by INAA in Comparison to Other Analytical Method Including ICP

    Int.Symp.on Trace Anal.Jechno.Analysis.   / , 83-85  1981

  • Significance of Hair Analysis Data obtained by INAA in Comparison to Other Analytical Method Including ICP

    Int.Symp.on Trace Anal.Jechno.Analysis.   / , 83-85  1981

  • Detection of IｇG antibody to measles by radioimmuno technique

    Hiroko Sakata, Katsuya Yamanouchi, Kazuhiko Machida, Fukashi Matsuzaki, Akira Shishido, Hiroshi Iwashita, Yshigoro Kuroiwa

    Jap.J.med.Sai.Biol   32 ( 2 ) 67 - 76  1979

    DOI

  • Detection of IｇG antibody to measles by radioimmuno technique

    Hiroko Sakata, Katsuya Yamanouchi, Kazuhiko Machida, Fukashi Matsuzaki, Akira Shishido, Hiroshi Iwashita, Yshigoro Kuroiwa

    Jap.J.med.Sai.Biol   32 ( 2 ) 67 - 76  1979

    DOI

  • Detection of I&G antibody to measles by radioimmuno technique

    Jap.J.med.Sai.Biol   32 ( 2 ) 67 - 76  1979

  • Detection of I&G antibody to measles by radioimmuno technique

    Jap.J.med.Sai.Biol   32 ( 2 ) 67 - 76  1979

  • Detection of I&G antibody to measles by radioimmuno technique

    Jap.J.med.Sai.Biol   32/2, 67-76  1979

  • Detection of I&G antibody to measles by radioimmuno technique

    Jap.J.med.Sai.Biol   32/2, 67-76  1979

  • Cadmium accumulations in mouse organs during the pequential injection of cadmium-109

    Junko Matsubara-Khan, Kazuhiko Machida

    Enviroument Research   10   29 - 38  1975

    DOI

  • Cadmium accumulations in mouse organs during the pequential injection of cadmium-109

    Junko Matsubara-Khan, Kazuhiko Machida

    Enviroument Research   10   29 - 38  1975

    DOI

  • Cadmium accumulations in mouse organs during the pequential injection of cadmium-109

    Enviroument Research   10   29 - 38  1975

    DOI

  • Cadmium accumulations in mouse organs during the pequential injection of cadmium-109

    Enviroument Research   10   29 - 38  1975

    DOI

  • 紀要、報告書、研究補助金報告書、学会誌・学術雑誌以外の論文、書評、そのほか学会発表以外の書き物

     

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Overseas Activities

  • ﾖｰﾛｯﾊﾟ、中国、日本の都市における高齢者施設の感染症対策と施設利用者の生きがいについて

    2009.03
    -
    2009.09

    ヨーロッハﾟ他  

Internal Special Research Projects

  • 高齢化社会の保健医療政策に及ぼす予防医学の役割－日本と中国の比較研究

    2004   太田冨貴雄, 吉村正

    　View Summary

    2003年9月から予定していた本研究費による天津市での調査が2003年冬から夏まで流行した中国のSARS騒動により打ち合わせが十分出来なかったため半年遅れて、3003年12月より医療費の調査を、2004の3月に初回の医療行動調査の検診を行った。検診は天津医科大学看護学部の学生(5年制)の協力により日本での調査同様な方式により以下の項目が行われた。１．面接調査：ストレス度、ＡＤＬ、モラールテスト、ライフイベント、食生活、酒､タバコ、既往歴、現在の健康状態、運動習慣、居住環境、生活習慣(家族構成等)、２．機能検査：血圧、体温、肺活量、握力、開眼片足立ち、棒反応時間、歩行能力。３．血清生化学検査16項目４．血液・好中球貪食能・活性酸素産生能（標本作りのみ、測定はこれから行う)。５．尿検査．この検診後から1年間万歩計(全員、週3回測定)）と血圧計(7人に1台、週1回1日3回測定)を配布し、運動量と家庭内血圧測定による血圧の管理を実施した。この調査を踏まえ、９月と3月に同様な調査を行った。受診率は3月月が95％、9月が85％、20005年3月が70％と日本では考えられないほどの受診率を示した(日本では約20％)。血液の国外持ち出しは禁止されているため血液関係の検査は天津医科大学に頼んだ。膨大なデーターのため現在集計中であるが、一部については未来医療研究所主催の2004年度7月と2005年度3月のシンポジュームおよび2005年3月に新潟市で行われた第74回日本衛生学会で下記のようにいろいろな側面から発表を行い、現在論文にまとめている。中国は共産主義体制をとっているが、医療保険制度の面では完全給付制度は崩れ、毎回実費で支払いを行い、年1回の精算という厳しい保険制度を採っており、政策的によりせっきょぃてきな予防医学的制度の徹底と代替医療の積極的導入の必要性を感じた。検診の結果によると食生活(油の使用の多いためか)拡張期血圧が以上に高く、またHDLコレステロールが低い傾向が認められた。今後の免疫学的結果を見てさらに考察を考えて生きたいと思う。

  • 加齢に伴う非特異免疫能の変化に及ぼす各種ライフスタイルの影響

    2002  

    　View Summary

    成人病予防の為には適度な運動、ストレスからの開放、さらに免疫を強化するための食生活や肥満の抑制が重要な鍵を握っている。これ等の要因が加齢に伴い生体防御機能にどのような影響を与えていくのかをラットを用いた研究で明らかにしょうとした。本研究を以下の3つに分け、いずれの研究もFischer系雄性ラットの5周齢（若齢群）、31周齢（壮年期群）、67周齢（高齢群）の3年齢群のラットを用い、各負荷を与えながら4ヶ月間飼育し、その後ラットをネンブタール麻酔下で解剖して各種生体防御機能（NBT法による好中球貪食・活性酸素産生能、肺胞マクロファージ活性酸素産生能、脾臓のNK細胞活性能とリンパ球幼若化能、臨床生化学検査）を調べた。１。加齢に伴う生体防御機能の変化とそれに及ぼす運動の影響：好中球非刺激試験では若齢群、壮年群に比べ高齢群は有意に高値を示　した。また高齢群の運動群は対照群に比べ有意に低値を示した。ブドウ球菌貪食試験では貪職能、活性酸素産生能ともに壮年群が他　の2群に比べ有意に高地を示したが、肺胞マクロファージの活性酸素産生能は若齢群で他の2群より有意に高値を示した。リンパ球幼　若化試験は壮年群がほかの2群より高値を示し、特にPWM刺激では運動群が有意に亢進した。年齢により各免疫反応は異なったが運動　の効果は認められた。　　２。加齢に伴う生体防御機能の変化とそれに及ぼす心理的ストレスの影響：心理的ストレスによりどの年齢においても好中球の活性酸　素産生能が抑制されたが、年齢の増加に従い貪食能との相関が低下することから好中球機能とのバランスが衰えてくることが推測さ　れた。幼若化では若齢群の亢進が認められたが、ストレスの影響は認められなかった。NK活性、肺胞マクロファージの活性酸素産生　能においては各郡での有意な差は認められなかった。３。加齢に伴う生体防御機能の変化とそれに及ぼす食事制限の影響：食餌制限は若齢群の幼若化能では機能亢進が認められたが、肺胞マクロファージの活性酸素産生能やNK細胞活性能では逆に若齢群では機能低下を示した。しかし、老齢群のNK活性のみは有意に機能亢　進を示した。

  • 高齢者のライフスタイルの向上が個人の健康および医療に及ぼす影響

    2000  

    　View Summary

    　予防より治療を重視した従来の健康保健制度や老人医療無料化制度のもとで、欧米では考えられないほど安易に医療機関を利用する習慣が形成された結果３分診療や病院の老人ホーム化が促進されたばかりでなく、近年の経済不振の中各種健康保健財政は莫大な赤字をかかへ、更なる医療費の個人負担の増加が検討されようとしている。しかも今後日本は今まで類を見ないほどの急速な高齢社会を迎えることが予想され、従来の医療に対する考えを抜本的に変えないと国民の負担はますます増すばかりになる。それを打開するためには国民一人一人が自分の健康に対する意識改革をし、予防医学的側面からより積極的な健康の維持と増進を図ることが要求される。われわれは平成１０年度より埼玉県名栗村にて予防医学を中心に据えた健康増進運動を行ってきており、今年度で３年目を迎えた。今年度も昨年同様７月後半に質問紙（問診、既往歴、ライフスタイル、日常生活動作、QOL、モラールなど）、機能検査（各種運動能力テスト、血圧、肺機能、骨密度など）、健康診断（各種尿検査、臨床生化学検査、血液学検査など）、生態防御機能検査（好中球機能検査、NK活性、フローサイトメトリーによる各種リンパ球検査など）からなる検診を実施した。参加者は７０名と少なかったが、以下のような結果を得た。各種ライフスタイルの中でストレスは特に大きな影響を与えQOL、生活満足度、ADL、健康状態などに大きな影響を与えていることが認められた。しかし、BMI、握力、各種臨床検査値とストレスとの関係は見出されなかった。また高齢者の自立度と健康関連指標との関係では自立度の高い人は握力や反射神経に優れ、栄養状態も良好な傾向がうかがわれた。フローサイトメトリーにより測定した各種免疫細胞（CD4，CD8，NK，NKTなど）と質問紙法との関係では男性のNKT細胞とストレスとの間で有意に高い相関が認められた以外は関係は見られなかった。

  • 高齢者のライフスタイルの向上が個人の健康および医療に及ぼす影響（予備調査）

    1998  

    　View Summary

    　成人病は生活慣習病ともいわれるほど日常生活と密接に結びついていることが明確となり、適切なライフスタイルによりその多くが予防可能と思われてきている。我々は予防医学的見地から、５年前より狭山市の老人クラブ会員と保健衛生センターの協力によりライフスタイルの改善による健康の維持増進と生きがいのある生活をめざし、健康診断と個人指導による健康増進運動を行ってきた。しかし対象者が老人クラブ会員であったためそれを一般の高齢者として普遍化するのは難しいばかりでなく、毎年７月に行う検診以外のデーターを使うことができなかった。そこで今年度より調査地を埼玉県名栗村に移し、全高齢者（約600人）を対象とし、質問紙による全数調査と昨年までと同様に応募者に対する検診をおこない、下記のような調査をおこなった。さらに、昨年はまだその時期ではないので実施をしなかったが、今後は住民検診データーやレセプトの調査も実施し、このような健康増進運動の実施と医療費との関係も含め、多くの視点から研究を行って行くつもりである。今年度は４月に全数調査を実施した後７月に４日間検診を実施した。　調査内容は身長、体重、体温、血圧、呼吸機能、体脂肪、運動能力（握力、肺活量、開眼片足立ち、歩行能力、柔軟性、敏捷性各テスト）、ライフスタイル（栄養、嗜好品、運動習慣、睡眠、趣味、家族構成、ストレス度、生活満足度、既往歴、現在の健康状況等の面接法による質問紙調査、尿検査、採血による15項目の臨床生化学検査・貧血検査及び生体防御機能検査（白血球分類、好中球による貧食・活性酸素産生能、ナチュラルキラー細胞活性）である。これらのすべてのデーターの集計を行い、各個人ごとにまとめ、２月に一人約５分から10分間の面接をし、ライフスタイルと健康・生きがいについての指導を行った。今後データーを集積し５年から10年間の追跡調査を行う予定である。

  • 健康教育を中心とした高齢者の健康増進運動とその効果の把握に関する研究

    1996  

    　View Summary

    　成人病は生活習慣病ともいわれる程日常生活と密接に結びついていることが明確となり、虚弱老人、寝たきり老人さらに痴呆性老人の多くは適切なライフスタイルによりその多くは予防が可能と思われてきている。我々はそのような予防医学的見地から、4年前より狭山市の老人クラブ会員と保健衛生センターの協力によりライフスタイルの改善による健康の維持増進と生きがいのある生活をめざした健康診断と個人指導による運動を行なってきた。　今年度は5年計画の4年目で以下のような方法により調査を行ない新しい知見をえた。本年度は男性59名、女性66名の参加により以下の項目について調査が行われた。調査内容：身長、体重、体温、血圧、運動能力(握力、肺活量、開眼片足立ち、)ライフスタイル(栄養、嗜好品、運動習慣、睡眠、住居環境、ストレス及びストレス耐性度、日常生活度等の面接法による質問紙調査、尿検査、採血による15項目の臨床生化学検査・貧血検査及び生態防御機能検査(好中球貧食・活性酸素＜スーパーオキサイド＞産生能、ナチュラルキラー＜NK＞細胞活性)を実施した。過去年間と同様な比較方法に加え、今年度は家族形態とストレスを含めたライフスタイルとの関係も調べた。その結果ストレス耐性度と活性酸素産生能、NK活性、悩みの解消手段の有無およびストレスと肥満との関係、コルチゾール産生能とNK活性との相関、適度な運動と非特異免疫、臨床検査値(脂質代謝と肝機能)、肥満抑制および生きがいと、また家族形態(独居、配偶者のみ同居、子供とのみ同居、配偶者と子供と同居等)と各種ライフスタイル(睡眠、運動習慣、ストレス耐性度等)との関係が認められた。今後このような結果相互の関係を多変量解析によって明らかにするとともに、これらの結果を生かした個人指導を行ない高齢者が健康で生きがいのある一生を送れるように支援したいと思う。

  • 適度な運動と健康教育を中心とした健康増進運動とその効果の把握に関する研究

    1995   太田　冨貴雄, 栗山　孝雄

    　View Summary

    目的： 数十年後の日本は人類がかって経験しなかった超高齢化社会を迎えようとしている。そのため，抜本的な保健活動の改革と年を取っても元気で生きがいのある生活を送れるような活動を推進する必要がある。そのために，基礎体力の向上，食生活の改善，余暇の過ごし方などの健康指導を中心とした住民運動を推進する調査を企画した。方法： 対象者：埼玉県狭山市の老人クラブ会員。1995年度150名（男：85名，女：65名，平均年齢72.2±5.5才），1996年度138名（男：73名，女：65名，平均年齢75.8才）を対象として各種ライフスタイルに関するアンケート調査（生活習慣，嗜好習慣，運動習慣，健康状態，既往症，食生活，ストレスに関する調査など），生理機能測定（血圧，握力，肺機能，肥満度，尿検査等）および血液検査（15項目の血清生化学検査，貧血検査，好中球貪食・活性酸素産生試験，フローサイトメトリーによるNK細胞数）を実施した。結果： 1. 食品摂取状況はおおむね良好であったが，特に80歳代が良かった。食品摂取状態の良好な人は好中球の貪食・細菌能の間に強い正の相関がみられたばかりでなく非刺激時試験で低い活性酸素産生能を示した。また，栄養に関係している血清中ALB, TPやCaの高い人は好中球貪食・細菌能が有意に高値を示した。2. 喫煙習慣のない人や男の少量の飲酒者は良好な好中球機能を示した。3. 週5回以上の運動習慣を持っている人はストレス度が有意に低値を示した。4. 悩みを解消する手段を持っている人は好中球の貪食・殺菌能の間に有意な相関関係を認めた。5. 6時間以下の睡眠時間の人は男女ともに非刺激時活性酸素産生が高値を示した。6. 女性のナチュラル細胞活性とストレス耐性度の間に正の相関が認められた。7. 生活活動度（ADL），アルコール摂取量とストレス度（SCL-S）との間に負の相関が認められた。

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