2022/01/28 更新

写真a

オカモト ユウコ
岡本 悠子
所属
附属機関・学校 高等研究所
職名
講師(任期付)
メールアドレス
メールアドレス

兼担

  • 人間科学学術院   大学院人間科学研究科

学歴

  • 2008年04月
    -
    2013年03月

    総合研究大学院大学   生命科学研究科   生理科学専攻  

  • 2004年04月
    -
    2008年03月

    順天堂大学   スポーツ健康科学部   スポーツ科学科  

学位

  • 総合研究大学院大学   博士(理学)

経歴

  • 2020年04月
    -
    継続中

    早稲田大学   高等研究所   講師(任期付)

  • 2020年04月
    -
    継続中

    福井大学   病態制御医学講座精神医学   特別研究員

  • 2020年04月
    -
    2021年03月

    東北大学   加齢医学研究所   共同研究員

  • 2018年04月
    -
    2020年03月

    株式会社国際電気通信基礎技術研究所   研究員

  • 2017年07月
    -
    2020年03月

    福井大学   子どものこころの発達研究センター   特別研究員

  • 2017年07月
    -
    2020年03月

    ATR-Promotions   脳活動イメージングセンタ   研究アドバイザー

  • 2017年10月
    -
    2018年03月

    大阪大学   連合小児発達学研究科   非常勤講師

  • 2014年05月
    -
    2017年06月

    大阪大学・金沢大学・浜松医科大学・千葉大学・福井大学 連合小児発達学研究科   助教

  • 2014年04月
    -
    2017年06月

    福井大学   子どものこころの発達研究センター   特命助教

  • 2013年04月
    -
    2014年03月

    鳥取大学   地域学部   プロジェクト研究員

  • 2010年04月
    -
    2013年03月

    日本学術振興会特別研究員(DC1)

▼全件表示

所属学協会

  •  
     
     

    U21 autism research network

  •  
     
     

    日本ヒト脳機能マッピング学会

  •  
     
     

    日本心理学会

  •  
     
     

    日本神経科学学会

 

研究分野

  • 精神神経科学

  • 教育心理学

  • 神経科学一般

  • 神経科学一般

研究キーワード

  • 自閉症

  • 発達

  • 発達障害

  • fMRI

  • 脳プロ

  • 包括脳ネットワーク

▼全件表示

論文

  • Importance of the early visual cortex and the lateral occipito-temporal cortex for the self-hand specific perspective process

    Yuko Okamoto, Ryo Kitada, Takanori Kochiyama, Motohide Miyahara, Hiroaki Naruse, Norihiro Sadato, Hidehiko Okazawa, Hirotaka Kosaka

    Neuroimage: Reports   1 ( 4 ) 100046 - 100046  2021年12月  [査読有り]

    担当区分:筆頭著者, 責任著者

    DOI

  • The extrastriate body area is involved in reciprocal imitation of hand gestures, vocalizations, and facial expressions: a univariate and multivariate fMRI study

    Yuko Okamoto, Ryo Kitada, Hiroki C. Tanabe, Akihiro T. Sasaki, Takanori Kochiyama, Noriaki Yahata, Norihiro Sadato

    Social Neuroscience    2021年06月  [査読有り]

    担当区分:筆頭著者, 責任著者

    DOI

  • Global perspectives on autism acceptance, camouflaging behaviours and mental health in autism spectrum disorder: A registered report protocol.

    Connor Tom Keating, Lydia Hickman, Philippine Geelhand, Toru Takahashi, Joan Leung, Bianca Schuster, Alicia Rybicki, Teresa Marie Girolamo, Elise Clin, Fanny Papastamou, Marie Belenger, Inge-Marie Eigsti, Jennifer Louise Cook, Hirotaka Kosaka, Rieko Osu, Yuko Okamoto, Sophie Sowden

    PloS one   16 ( 12 ) e0261774  2021年  [国際誌]

    DOI PubMed

  • Attenuated relationship between salivary oxytocin levels and attention to social information in adolescents and adults with autism spectrum disorder: a comparative study

    T. Fujioka, T. X. Fujisawa, K. Inohara, Y. Okamoto, Y. Matsumura, K. J. Tsuchiya, T. Katayama, T. Munesue, A. Tomoda, Y. Wada, H. Kosaka

    Annals of General Psychiatry   19 ( 1 )  2020年12月  [査読有り]

    DOI

  • Visual Body Part Representation in the Lateral Occipitotemporal Cortex in Children/Adolescents and Adults

    Yuko Okamoto, Ryo Kitada, Takanori Kochiyama, Hiroaki Naruse, Kai Makita, Motohide Miyahara, Hidehiko Okazawa, Hirotaka Kosaka

    Cerebral Cortex Communications   1 ( 1 )  2020年08月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    <title>Abstract</title>
    The lateral occipitotemporal cortex (LOTC) that responds to human bodies and body parts has been implicated in social development and neurodevelopmental disorders like autism spectrum disorder (ASD). Neuroimaging studies using a representational similarity analysis (RSA) revealed that body representation in the LOTC of typically developing (TD) adults is categorized into 3 clusters: action effector body parts, noneffector body parts, and face parts. However, its organization of younger people (i.e., children and adolescents) and its association with individual traits remain unclear. In this functional MRI study, TD adults and children/adolescents observed photographs of hands, feet, arms, legs, chests, waists, upper/lower faces, the whole body, and chairs. The univariate analysis showed that fewer child/adolescent participants showed left LOTC activation in response to whole-body images (relative to those of chairs) than adult participants. Contrastingly, the RSA on both age groups revealed a comparable body representation with 3 clusters of body parts in the bilateral LOTC. Hence, this result indicates that, although response to whole-body images can differ, LOTC body part representations for children/ adolescents and adults are highly similar. Furthermore, sensory atypicality is associated with spatial LOTC organization, suggesting the importance of this region for understanding individual difference, which is frequently observed in ASD.

    DOI

  • Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: a randomized clinical trial.

    Hidenori Yamasue, Takashi Okada, Toshio Munesue, Miho Kuroda, Toru Fujioka, Yota Uno, Kaori Matsumoto, Hitoshi Kuwabara, Daisuke Mori, Yuko Okamoto, Yuko Yoshimura, Yuki Kawakubo, Yuko Arioka, Masaki Kojima, Teruko Yuhi, Keiho Owada, Walid Yassin, Itaru Kushima, Seico Benner, Nanayo Ogawa, Yosuke Eriguchi, Naoko Kawano, Yukari Uemura, Maeri Yamamoto, Yukiko Kano, Kiyoto Kasai, Haruhiro Higashida, Norio Ozaki, Hirotaka Kosaka

    Molecular psychiatry   25 ( 8 ) 1849 - 1858  2020年08月  [査読有り]  [国際誌]

     概要を見る

    Although small-scale studies have described the effects of oxytocin on social deficits in autism spectrum disorder (ASD), no large-scale study has been conducted. In this randomized, parallel-group, multicenter, placebo-controlled, double-blind trial in Japan, 106 ASD individuals (18-48 y.o.) were enrolled between Jan 2015 and March 2016. Participants were randomly assigned to a 6-week intranasal oxytocin (48IU/day, n = 53) or placebo (n = 53) group. One-hundred-three participants were analyzed. Since oxytocin reduced the primary endpoint, Autism Diagnostic Observation Schedule (ADOS) reciprocity, (from 8.5 to 7.7; P < .001) but placebo also reduced the score (8.3 to 7.2; P < .001), no between-group difference was found (effect size -0.08; 95% CI, -0.46 to 0.31; P = .69); however, plasma oxytocin was only elevated from baseline to endpoint in the oxytocin-group compared with the placebo-group (effect size -1.12; -1.53 to -0.70; P < .0001). Among the secondary endpoints, oxytocin reduced ADOS repetitive behavior (2.0 to 1.5; P < .0001) compared with placebo (2.0 to 1.8; P = .43) (effect size 0.44; 0.05 to 0.83; P = .026). In addition, the duration of gaze fixation on socially relevant regions, another secondary endpoint, was increased by oxytocin (41.2 to 52.3; P = .03) compared with placebo (45.7 to 40.4; P = .25) (effect size 0.55; 0.10 to 1.0; P = .018). No significant effects were observed for the other secondary endpoints. No significant difference in the prevalence of adverse events was observed between groups, although one participant experienced temporary gynecomastia during oxytocin administration. Based on the present findings, we cannot recommend continuous intranasal oxytocin treatment alone at the current dose and duration for treatment of the core social symptoms of high-functioning ASD in adult men, although this large-scale trial suggests oxytocin's possibility to treat ASD repetitive behavior.

    DOI PubMed

  • Attenuated activation of the anterior rostral medial prefrontal cortex on self-relevant social reward processing in individuals with autism spectrum disorder

    Sumiya M, Okamoto Y, Koike T, Tanigawa T, Okazawa H, Kosaka H, Sadato N

    NeuroImage: Clinical    2020年03月  [査読有り]

    DOI

  • Differences between children and adults in functional connectivity between the inferior frontal gyrus and extrastriate body area for gestural interaction

    Okamoto Y, Kitada R, Seki A, Yanaka H, Kochiyama T, Koeda T

    Social neuroscience     1 - 13  2020年02月  [査読有り]  [国際誌]

    担当区分:筆頭著者, 責任著者

    DOI PubMed

  • Quantitative facial expression analysis revealed the efficacy and time course of oxytocin in autism.

    Keiho Owada, Takashi Okada, Toshio Munesue, Miho Kuroda, Toru Fujioka, Yota Uno, Kaori Matsumoto, Hitoshi Kuwabara, Daisuke Mori, Yuko Okamoto, Yuko Yoshimura, Yuki Kawakubo, Yuko Arioka, Masaki Kojima, Teruko Yuhi, Walid Yassin, Itaru Kushima, Seico Benner, Nanayo Ogawa, Naoko Kawano, Yosuke Eriguchi, Yukari Uemura, Maeri Yamamoto, Yukiko Kano, Kiyoto Kasai, Haruhiro Higashida, Norio Ozaki, Hirotaka Kosaka, Hidenori Yamasue

    Brain : a journal of neurology   142 ( 7 ) 2127 - 2136  2019年07月  [査読有り]  [国際誌]

     概要を見る

    Discrepancies in efficacy between single-dose and repeated administration of oxytocin for autism spectrum disorder have led researchers to hypothesize that time-course changes in efficacy are induced by repeated administrations of the peptide hormone. However, repeatable, objective, and quantitative measurement of autism spectrum disorder's core symptoms are lacking, making it difficult to examine potential time-course changes in efficacy. We tested this hypothesis using repeatable, objective, and quantitative measurement of the core symptoms of autism spectrum disorder. We examined videos recorded during semi-structured social interaction administered as the primary outcome in single-site exploratory (n = 18, crossover within-subjects design) and multisite confirmatory (n = 106, parallel-group design), double-blind, placebo-controlled 6-week trials of repeated intranasal administrations of oxytocin (48 IU/day) in adult males with autism spectrum disorder. The main outcomes were statistical representative values of objectively quantified facial expression intensity in a repeatable part of the Autism Diagnostic Observation Schedule: the maximum probability (i.e. mode) and the natural logarithm of mode on the probability density function of neutral facial expression and the natural logarithm of mode on the probability density function of happy expression. Our recent study revealed that increases in these indices characterize autistic facial expression, compared with neurotypical individuals. The current results revealed that oxytocin consistently and significantly decreased the increased natural logarithm of mode on the probability density function of neutral facial expression compared with placebo in exploratory (effect-size, -0.57; 95% CI, -1.27 to 0.13; P = 0.023) and confirmatory trials (-0.41; -0.62 to -0.20; P < 0.001). A significant interaction between time-course (at baseline, 2, 4, 6, and 8 weeks) and the efficacy of oxytocin on the natural logarithm of mode on the probability density function of neutral facial expression was found in confirmatory trial (P < 0.001). Post hoc analyses revealed maximum efficacy at 2 weeks (P < 0.001, Cohen's d = -0.78; 95% CI, -1.21 to -0.35) and deterioration of efficacy at 4 weeks (P = 0.042, Cohen's d = -0.46; 95% CI, -0.90 to -0.01) and 6 weeks (P = 0.10, Cohen's d = -0.35; 95% CI, -0.77 to 0.08), while efficacy was preserved at 2 weeks post-treatment (i.e. 8 weeks) (P < 0.001, Cohen's d = -1.24; 95% CI, -1.71 to -0.78). Quantitative facial expression analyses successfully verified the positive effects of repeated oxytocin on autistic individuals' facial expressions and demonstrated a time-course change in efficacy. The current findings support further development of an optimized regimen of oxytocin treatment.

    DOI PubMed

  • Local-to-distant development of the cerebrocerebellar sensorimotor network in the typically developing human brain: a functional and diffusion MRI study.

    Kaoru Amemiya, Tomoyo Morita, Daisuke N Saito, Midori Ban, Koji Shimada, Yuko Okamoto, Hirotaka Kosaka, Hidehiko Okazawa, Minoru Asada, Eiichi Naito

    Brain structure & function   224 ( 3 ) 1359 - 1375  2019年04月  [査読有り]  [国際誌]

     概要を見る

    Sensorimotor function is a fundamental brain function in humans, and the cerebrocerebellar circuit is essential to this function. In this study, we demonstrate how the cerebrocerebellar circuit develops both functionally and anatomically from childhood to adulthood in the typically developing human brain. We measured brain activity using functional magnetic resonance imaging while a total of 57 right-handed, blindfolded, healthy children (aged 8-11 years), adolescents (aged 12-15 years), and young adults (aged 18-23 years) (n = 19 per group) performed alternating extension-flexion movements of their right wrists in precise synchronization with 1-Hz audio tones. We also collected their diffusion MR images to examine the extent of fiber maturity in cerebrocerebellar afferent and efferent tracts by evaluating the anisotropy-sensitive index of hindrance modulated orientational anisotropy (HMOA). During the motor task, although the ipsilateral cerebellum and the contralateral primary sensorimotor cortices were consistently activated across all age groups, the functional connectivity between these two distant regions was stronger in adults than in children and adolescents, whereas connectivity within the local cerebellum was stronger in children and adolescents than in adults. The HMOA values in cerebrocerebellar afferent and efferent tracts were higher in adults than in children (some were also higher than in adolescents). The results indicate that adult-like cerebrocerebellar functional coupling is not completely achieved during childhood and adolescence, even for fundamental sensorimotor brain function, probably due to anatomical immaturity of cerebrocerebellar tracts. This study clearly demonstrated the principle of "local-to-distant" development of functional brain networks in the human cerebrocerebellar sensorimotor network.

    DOI PubMed

  • Distinct sensitivities of the lateral prefrontal cortex and extrastriate body area to contingency between executed and observed actions

    Sasaki AT, Okamoto Y, Kochiyama T, Kitada R, Sadato N

    Cortex   108   234 - 251  2018年08月  [査読有り]

    担当区分:筆頭著者

    DOI PubMed

  • Self-Face Recognition Begins to Share Active Region in Right Inferior Parietal Lobule with Proprioceptive Illusion During Adolescence.

    Morita T, Saito DN, Ban M, Shimada K, Okamoto Y, Kosaka H, Okazawa H, Asada M, Naito E

    Cerebral cortex (New York, N.Y. : 1991)   28 ( 4 ) 1532 - 1548  2018年02月  [査読有り]  [国際誌]

    DOI PubMed

  • Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder

    Yuko Okamoto, Ryo Kitada, Motohide Miyahara, Takanori Kochiyama, Hiroaki Naruse, Norihiro Sadato, Hidehiko Okazawa, Hirotaka Kosaka

    NEUROIMAGE-CLINICAL   19   384 - 395  2018年  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Background: Individuals with autism spectrum disorder (ASD) appear to have a unique awareness of their own body, which may be associated with difficulties of gestural interaction. In typically developing (TD) individuals, the perception of body parts is processed in various brain regions. For instance, activation of the lateral occipito-temporal cortex (LOTC) is known to depend on perspective (i.e., first-or third-person perspective) and identity (i.e., own vs. another person's body). In the present study, we examined how perspective and identity affect brain activation in individuals with ASD, and how perspective-and identity-dependent brain activation is associated with gestural imitation abilities.Methods: Eighteen young adults with ASD and 18 TD individuals participated in an fMRI study in which the participants observed their own or another person's hands from the first-and third-person perspectives. We examined whether the brain activation associated with perspective and identity was altered in individuals with ASD. Furthermore, we identified the brain regions the activity of which correlated with gestural imitation difficulties in individuals with ASD.Results: In the TD group, the left LOTC was more strongly activated by viewing a hand from the third-person perspective compared with the first-person perspective. This perspective effect in the left LOTC was significantly attenuated in the ASD group. We also observed significant group differences in the perspective effect in the medial prefrontal cortex (mPFC). Correlation analysis revealed that the perspective effect in the inferior parietal lobule (IPL) and cerebellum was associated with the gestural imitation ability in individuals with ASD.Conclusions: Our study suggests that atypical visual self-body recognition in individuals with ASD is associated with an altered perspective effect in the LOTC and mPFC, which are thought to be involved in the physical and core selves, respectively. Furthermore, the gestural imitation difficulty in individuals with ASD might be associated with the altered activation in the IPL and cerebellum, but not in the LOTC. These findings shed light on common and divergent neural mechanisms underlying atypical visual self-body awareness and gestural interaction in ASD.

    DOI PubMed

  • Development of Right-hemispheric Dominance of Inferior Parietal Lobule in Proprioceptive Illusion Task

    Eiichi Naito, Tomoyo Morita, Daisuke N. Saito, Midori Ban, Koji Shimada, Yuko Okamoto, Hirotaka Kosaka, Hidehiko Okazawa, Minoru Asada

    CEREBRAL CORTEX   27 ( 11 ) 5385 - 5397  2017年11月  [査読有り]

     概要を見る

    Functional lateralization can be an indicator of brain maturation. We have consistently shown that, in the adult brain, proprioceptive processing of muscle spindle afferents generating illusory movement of the right hand activates inferior frontoparietal cortical regions in a right-side dominant manner in addition to the cerebrocerebellar motor network. Here we provide novel evidence regarding the development of the right-dominant use of the inferior frontoparietal cortical regions in humans using this task. We studied brain activity using functional magnetic resonance imaging while 60 right-handed blindfolded healthy children (8-11 years), adolescents (12-15 years), and young adults (18-23 years) (20 per group) experienced the illusion. Adult-like right-dominant use of the inferior parietal lobule (IPL) was observed in adolescents, while children used the IPL bilaterally. In contrast, adult-like lateralized cerebrocerebellar motor activation patterns were already observable in children. The right-side dominance progresses during adolescence along with the suppression of the left-sided IPL activity that emerges during childhood. Therefore, the neuronal processing implemented in the adult's right IPL during the proprioceptive illusion task is likely mediated bilaterally during childhood, and then becomes right-lateralized during adolescence at a substantially later time than the lateralized use of the cerebrocerebellar motor system for kinesthetic processing.

    DOI PubMed

  • Age-dependent atypicalities in body- and face-sensitive activation of the EBA and FFA in individuals with ASD

    Yuko Okamoto, Hirotaka Kosaka, Ryo Kitada, Ayumi Seki, Hiroki C. Tanabe, Masamichi J. Hayashi, Takanori Kochiyama, Daisuke N. Saito, Hisakazu T. Yanaka, Toshio Munesue, Makoto Ishitobi, Masao Omori, Yuji Wada, Hidehiko Okazawa, Tatsuya Koeda, Norihiro Sadato

    NEUROSCIENCE RESEARCH   119   38 - 52  2017年06月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfunction of the extrastriate body area (EBA) and the fusiform face area (FFA), activation in these regions might be more atypical in children than in adults. We preformed functional magnetic resonance imaging while children and adults with ASD and age-matched typically developed (TD) individuals observed face, body, car, and scene. To examine various aspects, we performed individual region of interest (ROI) analysis, as well as conventional random effect group analysis. At individual ROI analysis, we examined the ratio of participants showing a category-sensitive response, the size of regions, location and activation patterns among the four object categories. Adults with ASD showed no atypicalities in activation of the EBA and FFA, whereas children with ASD showed atypical activation in these regions. Specifically, a smaller percentage of children with ASD showed face-sensitive activation of the FFA than TD children. Moreover, the size of the EBA was smaller in children with ASD than in TD children. Our results revealed atypicalities in both the FFA and EBA in children with ASD but not in adults with ASD. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

    DOI PubMed

  • SELF-FACE RECOGNITION SHARES BRAIN REGIONS ACTIVE DURING PROPRIOCEPTIVE ILLUSION IN THE RIGHT INFERIOR FRONTO-PARIETAL SUPERIOR LONGITUDINAL FASCICULUS III NETWORK

    Tomoyo Morita, Daisuke N. Saito, Midori Ban, Koji Shimada, Yuko Okamoto, Hirotaka Kosaka, Hidehiko Okazawa, Minoru Asada, Eiichi Naito

    NEUROSCIENCE   348   288 - 301  2017年04月  [査読有り]

     概要を見る

    Proprioception is somatic sensation that allows us to sense and recognize position, posture, and their changes in our body parts. It pertains directly to oneself and may contribute to bodily awareness. Likewise, one's face is a symbol of oneself, so that visual self-face recognition directly contributes to the awareness of self as distinct from others. Recently, we showed that right-hemispheric dominant activity in the inferior fronto-parietal cortices, which are connected by the inferior branch of the superior longitudinal fasciculus (SLF III), is associated with proprioceptive illusion (awareness), in concert with sensorimotor activity. Herein, we tested the hypothesis that visual self face recognition shares brain regions active during proprioceptive illusion in the right inferior fronto-parietal SLF III net-work. We scanned brain activity using functional magnetic resonance imaging while twenty-two right-handed healthy adults performed two tasks. One was a proprioceptive illusion task, where blindfolded participants experienced a proprioceptive illusion of right hand movement. The other was a visual self-face recognition task, where the participants judged whether an observed face was their own. We examined whether the self-face recognition and the proprioceptive illusion commonly activated the inferior fronto-parietal cortices connected by the SLF III in a right-hemispheric dominant manner. Despite the difference in sensory modality and in the body parts involved in the two tasks, both tasks activated the right inferior fronto-parietal cortices, which are likely connected by the SLF III, in a right-side dominant manner. Here we discuss possible roles for right inferior fronto-parietal activity in bodily awareness and self-awareness. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of IBRO.

    DOI PubMed

  • Decision making processes based on social conventional rules in early adolescents with and without autism spectrum disorders

    Hidetsugu Komeda, Hidekazu Osanai, Kaichi Yanaoka, Yuko Okamoto, Toru Fujioka, Sumiyoshi Arai, Keisuke Inohara, Masuo Koyasu, Takashi Kusumi, Shinichiro Takiguchi, Masao Kawatani, Hirokazu Kumazaki, Michio Hiratani, Akemi Tomoda, Hirotaka Kosaka

    SCIENTIFIC REPORTS   6   37875  2016年11月  [査読有り]

     概要を見る

    Autism spectrum disorder (ASD) is characterized by problems with reciprocal social interaction, repetitive behaviours/narrow interests, and impairments in the social cognition and emotional processing necessary for intention-based moral judgements. The aim of this study was to examine the information used by early adolescents with and without ASD when they judge story protagonists as good or bad. We predicted that adolescents with ASD would use protagonists' behaviour, while typically developing (TD) adolescents would use protagonists' characteristics when making the judgements. In Experiment 1, we measured sentence by sentence reading times and percentages for good or bad judgements. In Experiment 2, two story protagonists were presented and the participants determined which protagonist was better or worse. Experiment 1 results showed that the adolescents with ASD used protagonist behaviours and outcomes, whereas the TD adolescents used protagonist characteristics, behaviours, and outcomes. In Experiment 2, TD adolescents used characteristics information when making "bad" judgements. Taken together, in situations in which participants cannot go back and assess (Experiment 1), and in comparable situations in which all information is available (Experiment 2), adolescents with ASD do not rely on information about individual characteristics when making moral judgements.

    DOI PubMed

  • Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial

    H. Kosaka, Y. Okamoto, T. Munesue, H. Yamasue, K. Inohara, T. Fujioka, T. Anme, M. Orisaka, M. Ishitobi, M. Jung, T. X. Fujisawa, S. Tanaka, S. Arai, M. Asano, D. N. Saito, N. Sadato, A. Tomoda, M. Omori, M. Sato, H. Okazawa, H. Higashida, Y. Wada

    TRANSLATIONAL PSYCHIATRY   6 ( 8 ) e872  2016年08月  [査読有り]

     概要を見る

    Recent studies have suggested that long-term oxytocin administration can alleviate the symptoms of autism spectrum disorder (ASD); however, factors influencing its efficacy are still unclear. We conducted a single-center phase 2, pilot, randomized, double-blind, placebo-controlled, parallel-group, clinical trial in young adults with high-functioning ASD, to determine whether oxytocin dosage and genetic background of the oxytocin receptor affects oxytocin efficacy. This trial consisted of double-blind (12 weeks), open-label (12 weeks) and follow-up phases (8 weeks). To examine dose dependency, 60 participants were randomly assigned to high-dose (32 IU per day) or low-dose intranasal oxytocin (16 IU per day), or placebo groups during the double-blind phase. Next, we measured single-nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR). In the intention-to-treat population, no outcomes were improved after oxytocin administration. However, in male participants, Clinical Global Impression-Improvement (CGI-I) scores in the high-dose group, but not the low-dose group, were significantly higher than in the placebo group. Furthermore, we examined whether oxytocin efficacy, reflected in the CGI-I scores, is influenced by estimated daily dosage and OXTR polymorphisms in male participants. We found that 421 IU per day oxytocin was more effective than. 21 IU per day, and that a SNP in OXTR (rs6791619) predicted CGI-I scores for. 21 IU per day oxytocin treatment. No severe adverse events occurred. These results suggest that efficacy of long-term oxytocin administration in young men with high-functioning ASD depends on the oxytocin dosage and genetic background of the oxytocin receptor, which contributes to the effectiveness of oxytocin treatment of ASD.

    DOI PubMed

  • Altered frontal pole development affects self-generated spatial working memory in ADHD

    Sumiyoshi Arai, Yuko Okamoto, Toru Fujioka, Keisuke Inohara, Makoto Ishitobi, Yukiko Matsumura, Minyoung Jung, Kaori Kawamura, Shinichiro Takiguchi, Akemi Tomoda, Yuji Wada, Michio Hiratani, Naomi Matsuura, Hirotaka Kosaka

    BRAIN & DEVELOPMENT   38 ( 5 ) 471 - 480  2016年05月  [査読有り]

     概要を見る

    Background: Spatial working memory (SWM) dysfunction is a feature of attention deficit hyperactivity disorder (ADHD). Previous studies suggested that behavioral performance in self-generated SWM improves through development in children with and without ADHD. Nevertheless, developmental changes in the neural underpinnings of self-generated SWM are unknown.
    Method: Using near-infrared spectroscopy, hemodynamic activity in the prefrontal cortex (PFC) was measured in 30 children with ADHD (9.5 +/- 1.6 years-old) and 35 TD children (9.0 +/- 1.6 years-old) while they performed a self-generated SWM task. We then investigated correlations between age and behavioral performance, and between age and hemodynamic activity in the PFC for each group.
    Results: Both groups showed a negative correlation with age and number of errors [ADHD: r(28) = -0.37, p = 0.040; TD: r(33) = -0.59, p &lt; 0.001], indicating that self-generated SWM improves through development. The TD group showed a positive correlation between age and oxygenated hemoglobin in the frontal pole [10ch: r(33) = 0.41, p = 0.013; 11ch; r(33) = 0.44, p = 0.008] and bilateral lateral PFC [4ch: r(33) = 0.34, p = 0.049; 13ch; r(33) = 0.54, p = 0.001], while no significant correlation was found in the ADHD group. Furthermore, regression slopes for the frontal pole significantly differed between the TD and ADHD groups [10ch: t(61) = 2.35, p = 0.021; 11ch: t(61) = 2.05, p = 0.044].
    Conclusion: Children with ADHD showed abnormalities in functional maturation of the frontal pole, which plays a role in manipulating and maintaining information associated with self-generated behavior. (C) 2015 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

    DOI PubMed

  • Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults

    Toru Fujioka, Keisuke Inohara, Yuko Okamoto, Yasuhiro Masuya, Makoto Ishitobi, Daisuke N. Saito, Minyoung Jung, Sumiyoshi Arai, Yukiko Matsumura, Takashi X. Fujisawa, Kosuke Narita, Katsuaki Suzuki, Kenji J. Tsuchiya, Norio Mori, Taiichi Katayama, Makoto Sato, Toshio Munesue, Hidehiko Okazawa, Akemi Tomoda, Yuji Wada, Hirotaka Kosaka

    MOLECULAR AUTISM   7   19  2016年03月  [査読有り]

     概要を見る

    Background: Gaze abnormality is a diagnostic criterion for autism spectrum disorder (ASD). However, few easy-to-use clinical tools exist to evaluate the unique eye-gaze patterns of ASD. Recently, we developed Gazefinder, an all-in-one eye-tracking system for early detection of ASD in toddlers. Because abnormal gaze patterns have been documented in various ASD age groups, we predicted that Gazefinder might also detect gaze abnormality in adolescents and adults. In this study, we tested whether Gazefinder could identify unique gaze patterns in adolescents and adults with ASD.
    Methods: We measured the percentage of eye fixation time allocated to particular objects depicted in movies (i.e., eyes and mouth in human face movies, upright and inverted biological motion in movies that presented these stimuli simultaneously, and people and geometry in movies that presented these stimuli simultaneously) by male adolescents and adults with ASD (N = 26) and age-matched males with typical development (TD; N = 35). We compared these percentages between the two groups (ASD and TD) and with scores on the social responsiveness scale (SRS). Further, we conducted discriminant analyses to determine if fixation times allocated to particular objects could be used to discriminate between individuals with and without ASD.
    Results: Compared with the TD group, the ASD group showed significantly less fixation time at locations of salient social information (i.e., eyes in the movie of human faces without lip movement and people in the movie of people and geometry), while there were no significant groupwise differences in the responses to movies of human faces with lip movement or biological motion. In a within-group correlation analysis, a few of the fixation-time items correlated with SRS, although most of them did not. No items significantly correlated with SRS in both ASD and TD groups. The percentage fixation times to eyes and people, which exhibited large effect sizes for the group difference, could differentiate ASD and TD with a sensitivity of 81.0 % and a specificity of 80.0 %.
    Conclusions: These findings suggest that Gazefinder is potentially a valuable and easy-to-use tool for objectively measuring unique gaze patterns and discriminating between ASD and TD in male adolescents and adults.

    DOI PubMed

  • The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

    Yuko Okamoto, Makoto Ishitobi, Yuji Wada, Hirotaka Kosaka

    CNS & Neurological Disorders-Drug Targets   15 ( 5 ) 564 - 577  2016年  [査読有り]

    担当区分:筆頭著者

     概要を見る

    Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individuals with ASD. All studies suggest that single-dose and long-term administration are well tolerated, and no severe adverse events have been reported. However, the efficacy of long-term oxytocin administration is controversial. Some studies have reported significant improvement of the core symptoms of ASD by long-term oxytocin administration, while other studies showed no such improvement. To elucidate the factors influencing the efficacy of oxytocin administration, it is necessary to examine the effects of administration schedules (e.g., dosage amount, frequency per day) and participant characteristics (e.g., age, sex, intellectual ability). In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system. Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal oxytocin administration, which could be essential for establishing optimal oxytocin treatments for individuals with ASD.

    DOI PubMed

  • Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study.

    Shinichiro Takiguchi, Takashi X Fujisawa, Sakae Mizushima, Daisuke N Saito, Yuko Okamoto, Koji Shimada, Michiko Koizumi, Hirokazu Kumazaki, Minyoung Jung, Hirotaka Kosaka, Michio Hiratani, Yusei Ohshima, Martin H Teicher, Akemi Tomoda

    BJPsych open   1 ( 2 ) 121 - 128  2015年10月  [査読有り]  [国際誌]

     概要を見る

    BACKGROUND: Child maltreatment is a major risk factor for psychopathology, including reactive attachment disorder (RAD). AIMS: To examine whether neural activity during reward processing was altered in children and adolescents with RAD. METHOD: Sixteen children and adolescents with RAD and 20 typically developing (TD) individuals performed tasks with high and low monetary rewards while undergoing functional magnetic resonance imaging. RESULTS: Significantly reduced activity in the caudate and nucleus accumbens was observed during the high monetary reward condition in the RAD group compared with the TD group (P=0.015, family-wise error-corrected cluster level). Significant negative correlations between bilateral striatal activity and avoidant attachment were observed in the RAD and TD groups. CONCLUSIONS: Striatal neural reward activity in the RAD group was markedly decreased. The present results suggest that dopaminergic dysfunction occurs in the striatum of children and adolescents with RAD, leading towards potential future risks for psychopathology. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.

    DOI PubMed

  • Sex-different abnormalities in the right second to fourth digit ratio in Japanese individuals with autism spectrum disorders

    Yasuhiro Masuya, Yuko Okamoto, Keisuke Inohara, Yukiko Matsumura, Toru Fujioka, Yuji Wada, Hirotaka Kosaka

    MOLECULAR AUTISM   6   34  2015年06月  [査読有り]

     概要を見る

    Background: The prevalence of autism spectrum disorders (ASDs) is higher in men than in women. The extreme male brain theory proposes that excessive prenatal testosterone activity could be a risk factor for ASDs. However, it is unclear whether prenatal sex hormone activity is a risk factor for women. The ratio of the length of the second to fourth digits (2D:4D) is considered to be a biomarker of the prenatal ratio of testosterone to estrogen. Therefore, this study compared the 2D:4D ratios of women with and without ASDs to determine if prenatal sex hormone activity could be a risk factor for ASDs in women.
    Methods: The study included 35 Japanese men with ASDs, 17 Japanese women with ASDs, 59 typically developed (TD) Japanese men, and 57 TD Japanese women. We measured digit lengths and compared the 2D:4D ratios among the four groups. We also examined the relationship between the 2D:4D ratio and the autism-spectrum quotient score of each group.
    Results: In our cohort, men with ASDs tended to have lower right-hand 2D:4D ratios relative to TD men. In contrast, the right 2D:4D ratios in women with ASDs were higher compared to those of TD women. No significant correlations were found between the 2D:4D ratios and the autism-spectrum quotient scores in any group. The higher right 2D:4D ratios in women could not be explained by age or full-scale intelligent quotients. This group difference was not found for the left 2D:4D or right-left 2D:4D ratios.
    Conclusions: We found a reverse direction of abnormality in the right 2D:4D ratio for men and women with ASDs. It has been posited that high prenatal testosterone levels lead to a lower 2D:4D ratio. However, a recent animal study showed that testosterone injection to dam leads to a higher right 2D:4D ratio especially for female offspring, which might be mediated by abnormal adipose accumulation in the fingertip. Therefore, the present findings suggest that high prenatal testosterone could be a risk factor both for Japanese men and women with ASDs, elucidating one potential etiology of ASDs in women.

    DOI PubMed

  • Role of the precuneus in the detection of incongruency between tactile and visual texture information: A functional MRI study

    Ryo Kitada, Akihiro T. Sasaki, Yuko Okamoto, Takanori Kochiyama, Norihiro Sadato

    NEUROPSYCHOLOGIA   64   252 - 262  2014年11月  [査読有り]

     概要を見る

    Visual clues as to the physical substance of manufactured objects can be misleading. For example, a plastic ring can appear to be made of gold. However, we can avoid misidentifying an object's substance by comparing visual and tactile information. As compared to the spatial properties of an object (e.g., orientation), however, little information regarding physical object properties (material properties) is shared between vision and touch. How can such different kinds of information be compared in the brain? One possibility is that the visuo-tactile comparison of material information is mediated by associations that are previously learned between the two modalities. Previous studies suggest that a cortical network involving the medial temporal lobe and precuneus plays a critical role in the retrieval of information from long-term memory. Here, we used functional magnetic resonance imaging (fMRI) to test whether these brain regions are involved in the visuo-tactile comparison of material properties. The stimuli consisted of surfaces in which an oriented plastic bar was placed on a background texture. Twenty-two healthy participants determined whether the orientations of visually- and tactually-presented bar stimuli were congruent in the orientation conditions, and whether visually- and tactually-presented background textures were congruent in the texture conditions. The texture conditions revealed greater activation of the fusiform gyrus, medial temporal lobe and lateral prefrontal cortex compared with the orientation conditions. In the texture conditions, the precuneus showed greater response to incongruent stimuli than to congruent stimuli. This incongruency effect was greater for the texture conditions than for the orientation conditions. These results suggest that the precuneus is involved in detecting incongruency between tactile and visual texture information in concert with the medial temporal lobe, which is tightly linked with long-term memory. (C) 2014 Elsevier Ltd. All rights reserved.

    DOI PubMed

  • Attenuation of the contingency detection effect in the extrastriate body area in autism spectrum disorder

    Yuko Okamoto, Ryo Kitada, Hiroki C. Tanabe, Masamichi J. Hayashi, Takanori Kochiyama, Toshio Munesue, Makoto Ishitobi, Daisuke N. Saito, Hisakazu T. Yanaka, Masao Omori, Yuji Wada, Hidehiko Okazawa, Akihiro T. Sasaki, Tomoyo Morita, Shoji Itakura, Hirotaka Kosaka, Norihiro Sadato

    NEUROSCIENCE RESEARCH   87   66 - 76  2014年10月  [査読有り]

    担当区分:筆頭著者

     概要を見る

    Detection of the contingency between one's own behavior and consequent social events is important for normal social development, and impaired contingency detection may be a cause of autism spectrum disorder (ASD). To depict the neural underpinnings of this contingency effect, 19 adults with ASD and 22 control participants underwent functional MRI while imitating another's actions and their actions being imitated by the other. As the extrastriate body area (EBA) receives efference copies of one's own movements, we predicted that the EBA would show an atypical response during contingency detection in ASD. We manipulated two factors: the congruency of the executed and observed actions, and the order of action execution and observation. Both groups showed the congruency effect in the bilateral EBA during imitation. When action preceded observation, the left EBA of the control group showed the congruency effect, representing the response to being imitated, indicating contingency detection. The ASD group showed a reduced contingency effect in the left EBA. These results indicate that the function of the EBA in the contingency detection is altered in ASD. (C) 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

    DOI PubMed

  • From gestures to words: Spontaneous verbal labeling of complex sequential hand movements reduces fMRI activation of the imitation-related regions

    Motohide Miyahara, Ryo Kitada, Akihiro T. Sasaki, Yuko Okamoto, Hiroki C. Tanabe, Norihiro Sadato

    NEUROSCIENCE RESEARCH   75 ( 3 ) 228 - 238  2013年03月  [査読有り]

     概要を見る

    The association of verbal labels with visuo-spatial patterns and sequences detectably alters neuronal activity in the brain in ways that have yet to be fully characterized. This study investigated the neural substrates involved in the effect of spontaneous verbal labeling on memorizing increasingly complex sequences of hand movements. We used functional magnetic resonance imaging (fMRI) to test our hypothesis that when verbal labels were employed, neuronal activity in imitation-related regions, such as the left inferior frontal gyrus (IFG), would be reduced, whereas without verbal labels, neuronal activation would increase. Sixteen healthy adults satisfactorily performed an immediate imitation task involving six levels of increasing complexity. After the fMRI experiment, participants reported at which complexity level they had formed verbal labels. Based on the self-report, we categorized the task blocks at each complexity level as either with verbal labeling (VL+) or without (VL-). Compared with VL+, the VL- condition activated the left IFG, bilateral middle frontal gyri, left precentral gyrus, and the right angular gyrus, whereas the opposite contrast revealed no significant brain activation. Verbal labeling seems to serve as an efficient heuristic that reduces the cost of cortical activation in the imitation-related regions. (C) 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

    DOI PubMed

  • Early visual experience and the recognition of basic facial expressions: involvement of the middle temporal and inferior frontal gyri during haptic identification by the early blind

    Ryo Kitada, Yuko Okamoto, Akihiro T. Sasaki, Takanori Kochiyama, Motohide Miyahara, Susan J. Lederman, Norihiro Sadato

    FRONTIERS IN HUMAN NEUROSCIENCE   7   7  2013年01月  [査読有り]

     概要を見る

    Face perception is critical for social communication. Given its fundamental importance in the course of evolution, the innate neural mechanisms can anticipate the computations necessary for representing faces. However, the effect of visual deprivation on the formation of neural mechanisms that underlie face perception is largely unknown. We previously showed that sighted individuals can recognize basic facial expressions by haptics surprisingly well. Moreover, the inferior frontal gyrus (IFG) and posterior superior temporal sulcus (pSTS) in the sighted subjects are involved in haptic and visual recognition of facial expressions. Here, we conducted both psychophysical and functional magnetic-resonance imaging (fMRI) experiments to determine the nature of the neural representation that subserves the recognition of basic facial expressions in early blind individuals. In a psychophysical experiment, both early blind and sighted subjects haptically identified basic facial expressions at levels well above chance. In the subsequent fMRI experiment, both groups haptically identified facial expressions and shoe types (control). The sighted subjects then completed the same task visually. Within brain regions activated by the visual and haptic identification of facial expressions (relative to that of shoes) in the sighted group, corresponding haptic identification in the early blind activated regions in the inferior frontal and middle temporal gyri. These results suggest that the neural system that underlies the recognition of basic facial expressions develops supramodally even in the absence of early visual experience.

    DOI PubMed

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書籍等出版物

Misc

  • 子どもの発達と自閉スペクトラム症の心理・脳科学研究

    岡本悠子

    発達精神医学研究所紀要   6   54 - 60  2021年03月  [招待有り]

    担当区分:筆頭著者, 責任著者

    記事・総説・解説・論説等(大学・研究所紀要)  

  • 第50回大会報告: 共感性と音楽 - ホルモンから読み解く-

    森下修次, 福井一, 岡本悠子, 豊島久美子, 小川容子

    音楽教育学   49 ( 2 ) 59 - 60  2020年

    会議報告等  

  • 自閉スペクトラム症の新しい治療薬の可能性~オキシトシン~

    小坂浩隆, 岡本悠子

    チャイルドヘルス   19 ( 5 ) 27 - 32  2016年05月

    記事・総説・解説・論説等(学術雑誌)  

  • 児童・青年期の脳機能画像研究 2.fMRI

    岡本悠子, 新井清義, 齋藤大輔, 小坂浩隆

    児童青年精神医学とその近接領域   56 ( 5 )  2015年11月  [査読有り]  [招待有り]

    記事・総説・解説・論説等(学術雑誌)  

  • 自閉スペクトラム症の脳画像研究 (特集 自閉症研究の最前線)

    小坂 浩隆, 岡本 悠子, 丁 ミンヨン

    精神科 = Psychiatry   27 ( 4 ) 265 - 270  2015年10月

    記事・総説・解説・論説等(学術雑誌)  

    CiNii

  • 小学校の異年齢集団交流による児童間の親密度の変化

    岡本 悠子, 大野 桂, 小枝 達也

    地域学論集 : 鳥取大学地域学部紀要   10 ( 3 ) 85 - 89  2014年03月

    速報,短報,研究ノート等(大学,研究機関紀要)  

    CiNii

  • 【社会脳科学:領域を越えた融合と発展】 自閉症スペクトラム障害の社会性障害を探る fMRI研究

    小坂 浩隆, 田邊 宏樹, 守田 知代, 岡本 悠子, 齋藤 大輔, 石飛 信, 棟居 俊夫, 和田 有司, 定藤 規弘

    日本生物学的精神医学会誌   23 ( 4 ) 255 - 261  2012年12月

    記事・総説・解説・論説等(学術雑誌)  

    DOI

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産業財産権

  • 自閉スペクトラム症への治療効果予測のための検査方法

    特許第6596632号

    小坂 浩隆, 岡本 悠子

    特許権

    J-GLOBAL

受賞

  • 優秀社長ファンド提案賞

    2019年04月   株式会社国際電気通信基礎技術研究所  

    受賞者: 岡本悠子

  • ベストポスター賞

    2015年03月   日本ヒト脳機能マッピング学会  

    受賞者: 岡本悠子

  • 2015年度前期 優秀論文 (責任著者)

    2015年   福井大学医学部  

    受賞者: 岡本悠子

  • 総合研究大学院大学 ポスター最優秀賞

    2012年12月  

    受賞者: 岡本悠子

  • 若手奨励賞

    2011年09月   日本ヒト脳機能マッピング学会  

    受賞者: 岡本悠子

  • 総合研究大学院大学 ポスター最優秀賞

    2009年12月  

    受賞者: 岡本悠子

▼全件表示

共同研究・競争的資金等の研究課題

  • 高次視覚野発達による自閉症のサブグループ化と認知行動特性・初期兆候の探索

    日本学術振興会  科学研究費助成事業 基盤研究(C)

    研究期間:

    2021年04月
    -
    2025年03月
     

    岡本 悠子

  • 自閉スペクトラム症における触覚と社会性の関係性の解明

    日本学術振興会  科学研究費助成事業 国際共同研究加速基金(帰国発展研究)

    研究期間:

    2021年
    -
    2024年
     

    北田 亮

  • 自閉症の文化心理学研究に向けた国際デー タベースの構築

    日本学術振興会  外国人研究者招へい事業 外国人招へい研究者(短期)

    研究期間:

    2022年02月
     
     
     

  • 自閉スペクトラム症の運動障害と社会性障害に共通の脳内メカニズムは存在するか?

    日本学術振興会  科学研究費助成事業 若手研究(B)

    研究期間:

    2017年04月
    -
    2021年03月
     

    岡本 悠子

     概要を見る

    自閉スペクトラム症は、社会性障害を中核症状とする発達障害である。自閉スペクトラム症児の多くが運動の苦手さを呈するが、運動障害と社会性障害に共通の生理学メカニズムがあるか、それとも異なる生理学的メカニズムがそれぞれの症状を引き超すかは不明である。本研究は、自閉スペクトラム症の運動障害と社会性障害が共通のメカニズムによって生じるか、fMRI研究を用いて検証することを目的としている。
    2019年度は、定型発達児を対象にfMRI実験を行い、人を見たときに強く活動する高次視覚野の領域の様々な身体部位を見たときの空間的な活動パターンを表象類似度解析を用いて検討した結果、先行研究と同様に四肢、胴、顔にクラスター化されることがわかった。自閉症傾向をAQ・SRS、感覚特性をSP、運動特性をMABC-2・DCDQを用いて評価し、クラスター化の度合いとの関係を調べたところ、感覚回避の傾向が強い児はより鮮明にクラスター化されることがわかった(Okamoto et al. 2020)。
    さらに、同じ課題を成人自閉スペクトラム症者を対象にした実験を遂行し、現在データ解析を行っているところである。

  • 自閉症児の社会性の発達を促す相互模倣の神経基盤

    日本学術振興会  科学研究費助成事業 特別研究員奨励費

    研究期間:

    2010年
    -
    2012年
     

    岡本 悠子

     概要を見る

    自閉症スペクトラム(ASD)は相互模倣(他者の動作を模倣すること;模倣、他者から模倣されること;被模倣)に障害を持ち、ASD児は相互模倣を用いた介入によって社会性・コミュニケーション能力の向上を示すことがわかっている。研究代表者はASD児への介入効果を測る生理学的指標の確立をめざし、ASDにおいて相互模倣の神経基盤について研究を行ってきた。前年度までに、健常成人を対象として相互模倣に関わる神経基盤を同定し、成人ASDを対象に相互模倣課題を用いてfMRI研究を実施してきた。当該年度は、成人ASDを対象にした研究の解析及び論文執筆を進めた結果、成人ASDでは健常成人と比較し自動な模倣や被模倣に関わる領域に活動低下を示したが、自発的な模倣に関わる活動に非典型性は見られなかった。この結果は成人ASDでは自発的な社会行動は獲得できるが、自動的な社会行動に障害が残るという仮説を支持する結果である。また、成人ASDで獲得された自発的な模倣能力も、ASD児においては障害を示すことがわかっている。また、ASD児においても自発的な模倣能力は発達に伴い行動することから、ASD児では自発的な模倣に関わる活動に非典型性を示し、模倣能力の向上とともに活動が改善すると考えられる。そこで、当該年度はASD児を対象とした研究を進めるため、相互模倣課題の改良し予備実験を実施した。現在、小児でも実施できる課題作成のため課題の簡略化、時間短縮を行い、健常児を対象にfMRI実験を開始するところである。

講演・口頭発表等

  • 子どもの発達と自閉スペクトラム症の心理・脳科学研究

    岡本悠子  [招待有り]

    岐阜県希望が丘こども医療福祉センター 発達精神医学研究所 児童精神保健研究会  

    発表年月: 2020年09月

  • ラウンドテーブル: 共感性と音楽 ― ホルモンから読み解く

    企画, 司会, 森下修次, 話題提供, 福井一, 岡本悠子, 豊島久美子, 指定討論, 小川容子

    日本音楽教育学会第50回大会  

    発表年月: 2019年10月

  • シンポジウム: ヒトにおいて他者とは何か?:自他認知において想定される階層的構造

    企画者, 司会者, 北田亮, 月浦崇, 話題提供, 杉浦元亮, 勝見佑太, 岡本悠子, 指定討論, 高橋英之

    日本心理学会第82回大会  

    発表年月: 2018年09月

  • fMRIで調べる身体認知と対人コミュニケーションの神経基盤:定型発達者と自閉スペクトラム症者の脳機能の違い

    岡本悠子  [招待有り]

    順天堂大学 スポーツ健康医科学研究所 第14回所外セミナー  

    発表年月: 2018年02月

特定課題研究

  • 自閉スペクトラム症の高次視覚野発達に関する文献レビュー

    2020年  

     概要を見る

    脳情報解読と機能的結合解析を用いることで、高次視覚野と初期視覚野の機能的結合が手のidentity(自分の手・他者の手)とPerspective(一人称視点・三人称視点)の統合に関与することを明らかにした。また、単変量解析と脳情報解読を用いることで、高次視覚野が身体部位の種類(手・顔)と動作(ジェスチャー、表情、発声)にかかわらず相互模倣時に自分の動きと他者の動きを比較し同一性を検出することも明らかにした。いずれも定型発達者を対象とした研究ではあるが、自閉スペクトラム症者で活動低下が認められるという報告の多い高次視覚野の機能について基礎的な知見を積み重ねることで、自閉スペクトラム症の方の脳機能発達をより深く理解することにつながると考えられる。また、この研究成果は2本の論文としてまとめ、現在査読中である。

 

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