2022/01/28 更新

写真a

ハイジマ アサヒ
配島 旭
所属
人間科学学術院 人間科学部
職名
講師(任期付)

経歴

  • 2019年04月
    -
    継続中

    早稲田大学   人間科学学術院   講師

  • 2011年08月
    -
    2019年03月

    群馬大学   大学院医学系研究科   助教

  • 2008年12月
    -
    2011年07月

    東京大学   大学院医学系研究科疾患生命工学センター健康環境医工学部門   特任研究員

 

論文

  • Neurotoxic effects of lactational exposure to perfluorooctane sulfonate on learning and memory in adult male mouse

    Abdallah Mshaty, Asahi Haijima, Yusuke Takatsuru, Ayane Ninomiya, Hiroyuki Yajima, Michifumi Kokubo, Miski Aghnia Khairinisa, Wataru Miyazaki, Izuki Amano, Noriyuki Koibuchi

    Food and Chemical Toxicology   145   111710 - 111710  2020年11月  [査読有り]  [国際誌]

    担当区分:責任著者

     概要を見る

    The present study aims to examine the effect of early lactational perfluorooctane sulfonate (PFOS) exposures on learning and memory in male mice and reveal the underlying mechanisms involved. PFOS solution was orally administered to dams from the postpartum days 1-14, so that pups would be exposed through breast milk. At 8-10 weeks of age, we performed object location test (OLT), object recognition test (ORT), and pairwise visual discrimination (VD) task. We also performed in vivo microdialysis, and mRNA and protein analysis of genes responsible for hippocampal development and function. In both OLT and ORT, the performance of mice in the PFOS-exposed group was significantly lower than those in the control group. In the VD task, the PFOS-exposed group learned significantly slower than the control group. Concentrations of glutamate and gamma-aminobutyric acid in the dorsal hippocampus were significantly higher in the PFOS-exposed group than in the control group. No notable differences were shown in our mRNA and protein studies. The present study showed that lactational PFOS exposure has a profound, long-lasting neurotoxic effect in the hippocampus and consequently leads to learning and memory deficits.

    DOI PubMed

  • A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development

    Shin‐ichiro Horigane, Yukihiro Ozawa, Jun Zhang, Hiroe Todoroki, Pan Miao, Asahi Haijima, Yuchio Yanagawa, Shuhei Ueda, Shigeo Nakamura, Masaki Kakeyama, Sayaka Takemoto‐Kimura

    FEBS Open Bio    2020年07月  [査読有り]

    DOI

  • In utero and postnatal propylthiouracil-induced mild hypothyroidism impairs maternal behavior in mice

    Miski Aghnia Khairinisa, Yusuke Takatsuru, Izuki Amano, Michifumi Kokubo, Asahi Haijima, Wataru Miyazaki, Noriyuki Koibuchi

    Frontiers in Endocrinology   9 ( MAY ) 228  2018年05月  [査読有り]

     概要を見る

    Thyroid hormones (THs) play crucial roles in general and brain development. Even if the hypothyroidism is mild, it may alter brain function, resulting in irreversible behavioral alterations. Although various behavioral analyses have been conducted, the effects of propylthiouracil (PTU) treatment during in utero and postnatal periods on maternal behavior have not yet been studied. The present study examined in mice whether THs insufficiency during development induce behavioral changes. Pregnant C57BL/6j mice were divided into three groups, and each group was administered different dosages of PTU (0, 5, or 50 ppm) in drinking water during in utero and postnatal periods (from gestational day 14 to postnatal day 21). First, locomotor activity and cognitive function were assessed in the offspring at 10 weeks. Next, female offspring were mated with normal mice and they and their offspring were used to assess several aspects of maternal behavior (identifying first pup, returning all pups to nest, time spent nursing, and licking pups). As expected, locomotor and cognitive functions in these mice were disrupted in a PTU dose-dependent manner. On postpartum day 2, dams who had been exposed 50 ppm PTU during in utero and postnatal periods displayed a significantly longer time identifying the first pup and returning all three pups back to the nest, less time nursing, and decreased licking behavior. The decrease in maternal behavior was significantly correlated with a decrease in cognition. These results indicate that insufficiency of THs during in utero and postnatal periods impairs maternal behavior, which may be partly induced by impaired cognitive function.

    DOI

  • Early-life stress induces cognitive disorder in middle-aged mice

    Hiroyuki Yajima, Asahi Haijima, Miski Aghnia Khairinisa, Noriaki Shimokawa, Izuki Amano, Yusuke Takatsuru

    Neurobiology of Aging   64   139 - 146  2018年04月  [査読有り]

     概要を見る

    Early-life stress can induce several neuropsychological disorders in adulthood. However, the underlying mechanisms inducing such disorders are still not fully understood. Furthermore, the effects of early-life stress on the changes in cognitive function with age are still not clarified. In this study, we used maternal deprivation (MD) to examine the cognitive function in middle-aged mice using a touchscreen-equipped operant chamber. In the visual-discrimination task, the aged (∼1.4 years old) control mice could accurately learn to discriminate between different visual stimuli. In contrast, the correct response rate of aged MD mice increased to ∼60% by day 10
    it was still significantly lower than that of the control mice (85%). In the hippocampus of aged MD mice, the expression level of the N-methyl-d-aspartate receptor subunit GluN1 decreased significantly as compared to that in control mice. On the other hand, no significant difference in GluN1 expression level was detected in young (2.5 months old) mice. These findings indicate that early-life stress accelerates cognitive impairment in middle-aged mice.

    DOI PubMed

  • Inhibitory neuron-specific Cre-dependent red fluorescent labeling using VGAT BAC-based transgenic mouse lines with identified transgene integration sites

    Ryosuke Kaneko, Yusuke Takatsuru, Ayako Morita, Izuki Amano, Asahi Haijima, Itaru Imayoshi, Nobuaki Tamamaki, Noriyuki Koibuchi, Masahiko Watanabe, Yuchio Yanagawa

    Journal of Comparative Neurology   526 ( 3 ) 373 - 396  2018年02月  [査読有り]

     概要を見る

    Inhibitory neurons are crucial for shaping and regulating the dynamics of the entire network, and disturbances in these neurons contribute to brain disorders. Despite the recent progress in genetic labeling techniques, the heterogeneity of inhibitory neurons requires the development of highly characterized tools that allow accurate, convenient, and versatile visualization of inhibitory neurons in the mouse brain. Here, we report a novel genetic technique to visualize the vast majority and/or sparse subsets of inhibitory neurons in the mouse brain without using techniques that require advanced skills. We developed several lines of Cre-dependent tdTomato reporter mice based on the vesicular GABA transporter (VGAT)-BAC, named VGAT-stop-tdTomato mice. The most useful line (line #54) was selected for further analysis based on two characteristics: the inhibitory neuron-specificity of tdTomato expression and the transgene integration site, which confers efficient breeding and fewer adverse effects resulting from transgene integration-related genomic disruption. Robust and inhibitory neuron-specific expression of tdTomato was observed in a wide range of developmental and cellular contexts. By breeding the VGAT-stop-tdTomato mouse (line #54) with a novel Cre driver mouse line, Galntl4-CreER, sparse labeling of inhibitory neurons was achieved following tamoxifen administration. Furthermore, another interesting line (line #58) was generated through the unexpected integration of the transgene into the X-chromosome and will be used to map X-chromosome inactivation of inhibitory neurons. Taken together, our studies provide new, well-characterized tools with which multiple aspects of inhibitory neurons can be studied in the mouse.

    DOI PubMed

  • Effects of Mild Perinatal Hypothyroidism on Cognitive Function of Adult Male Offspring

    Amano, Izuki, Takatsuru, Yusuke, Khairinisa, Miski Aghnia, Kokubo, Michifumi, Haijima, Asahi, Koibuchi, Noriyuki

    ENDOCRINOLOGY   159 ( 4 ) 1910 - 1921  2018年  [査読有り]

    DOI PubMed

  • Differential neurotoxic effects of in utero and lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) on spontaneous locomotor activity and motor coordination in young adult male mice

    Asahi Haijima, Ronny Lesmana, Noriaki Shimokawam, Izuki Amano, Yusuke Takatsuru, Noriyuki Koibuchi

    JOURNAL OF TOXICOLOGICAL SCIENCES   42 ( 4 ) 407 - 416  2017年08月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    We investigated whether in utero or lactational exposure to 4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl (OH-PCB 106) affects spontaneous locomotor activity and motor coordination in young adult male mice. For in utero exposure, pregnant C57BL/6J mice received 0.05 or 0.5 mg/kg body weight of OH-PCB 106 or corn oil vehicle via gavage every second day from gestational day 10 to 18. For lactational exposure, the different groups of dams received 0.05 or 0.5 mg/kg body weight of OH-PCB 106 or corn oil vehicle via gavage every second day from postpartum day 3 to 13. At 6-7 weeks of age, the spontaneous locomotor activities of male offspring were evaluated for a 24-hr continuous session in a home cage and in an open field for 30-min. Motor coordination function on an accelerating rotarod was also measured. Mice exposed prenatally to OH-PCB 106 showed increased spontaneous locomotor activities during the dark phase in the home cage and during the first 10-min in the open field compared with control mice. Mice exposed lactationally to OH-PCB 106, however, did not show a time-dependent decrease in locomotor activity in the open field. Instead, their locomotor activity increased significantly during the second 10-min block. In addition, mice exposed lactationally to OH-PCB 106 displayed impairments in motor coordination in the rotarod test. These results suggest that perinatal exposure to OH-PCB 106 affects motor behaviors in young adult male mice. Depending on the period of exposure, OH-PCB 106 may have different effects on neurobehavioral development.

    DOI

  • Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors

    Izuki Amano, Yusuke Takatsuru, Syutaro Toya, Asahi Haijima, Toshiharu Iwasaki, Helmut Grasberger, Samuel Refetoff, Noriyuki Koibuchi

    THYROID   26 ( 5 ) 741 - 752  2016年05月  [査読有り]

     概要を見る

    Background: Thyroid hormone (TH) plays a key role in the developing brain, including the cerebellum. TH deficiency induces organizational changes of the cerebellum, causing cerebellar ataxia. However, the mechanisms causing these abnormalities are poorly understood. Various animal models have been used to study the mechanism. Lacking dual oxidase (DUOX) and its maturation factor (DUOXA) are major inducers of congenital hypothyroidism. Thus, this study examined the organizational changes of the cerebellum using knockout mice of the Duoxa gene (Duoxa-/-).
    Methods: The morphological, behavioral, and electrophysiological changes were analyzed in wild type (Wt) and Duoxa-deficient (Duoxa-/-) mice frompostnatal day (P) 10 to P30. To detect the changes in the expression levels of presynaptic proteins, Western blot analysis was performed.
    Results: The proliferation and migration of granule cells was delayed after P15 in Duoxa-/-mice. However, these changes disappeared by P25. Although the cerebellar structure of Duoxa-/-mice was not significantly different from that of Wt mice at P25, motor coordination was impaired. It was also found that the amplitude of paired-pulse facilitation at parallel fiber-Purkinje cell synapses decreased in Duoxa-/-mice, particularly at P15. There were no differences between expression levels of presynaptic proteins regulating neurotransmitter release at P25.
    Conclusions: These results indicate that the anatomical catch-up growth of the cerebellum did not normalize its function because of the disturbance of neuronal circuits by the combined effect of hypothyroidism and functional disruption of the DUOX/DUOXA complex.

    DOI

  • ラットの長期記憶機能における後部帯状皮質および海馬の役割

    蓜島 旭, 一谷 幸男

    行動科学   55 ( 1 ) 81 - 93  2016年  [査読有り]

    担当区分:筆頭著者, 責任著者

  • Altered Cerebellum Development and Dopamine Distribution in a Rat Genetic Model with Congenital Hypothyroidism

    N. Shimokawa, B. Yousefi, S. Morioka, S. Yamaguchi, A. Ohsawa, H. Hayashi, A. Azuma, H. Mizuno, M. Kasagi, H. Masuda, H. Jingu, S. -I. Furudate, A. Haijima, Y. Takatsuru, T. Iwasaki, M. Umezu, N. Koibuchi

    JOURNAL OF NEUROENDOCRINOLOGY   26 ( 3 ) 164 - 175  2014年03月  [査読有り]

     概要を見る

    Thyroid hormones play crucial roles in the development and functional maintenance of the central nervous system. Despite extensive studies of the neural function of thyroid hormones, little is known about the effects of hypothyroidism on behavioural traits and the mechanisms underlying such effects. In the present study, we report an investigation of congenitally hypothyroid mutant rdw rats, revealing a novel function of thyroid hormones in the central nervous system. The rdw rats were subjected to behavioural analyses such as the rotarod test, open field test and circadian activity measurement. To determine the cause of behavioural disorders, cerebellar morphogenesis was examined by immunohistochemical analysis, and the axonal transport of dopamine in the nigrostriatal pathway was analysed by high-performance liquid chromatography and western blotting. The effects of thyroxine administration to the rdw rats were examined by behavioural analysis. The rdw rats showed severe impairment of motor coordination and balance. This could be explained by the fact that the rats showed severe retardation of cerebellar morphogenesis, which correlates with the small somata and poor dendritic arborisation of Purkinje cells and retarded migration of granule cells particularly during the first two postnatal weeks. Moreover, the rdw rats showed hypoactivity, characterised by decreased circadian locomotor activity. After weaning, thyroxine administration improved the dwarfism in rdw rats but had no effect on cerebellar function. In addition, the rdw rats showed anxiety and depression intrinsically to novel surroundings. Interestingly, the rdw rats showed high levels of dopamine in the substantia nigra and low levels in the striatum, an important centre for the coordination of behaviour. Furthermore, low levels of tubulin in the striatum were detected, indicating the aberrant axonal transport of dopamine in the nigrostriatal pathway as a result of the reduced delivery of microtubules. These findings indicate an important function of thyroid hormones in cerebellar formation and in the regulation of axonal transport of dopamine. Moreover, rdw rats will be useful for studies of brain function and behavioural disorders in congenital hypothyroidism.

    DOI

  • 胎仔期・授乳期の低用量水酸化PCB曝露が成熟後仔マウスへ及ぼす影響

    蓜島 旭, 下川 哲昭, 高鶴 裕介, 天野 出月, レスマナ ロニー, 鯉淵 典之

    日本毒性学会学術年会   40 ( 0 ) 2002100 - 2002100  2013年

     概要を見る

    発達期の脳は非常に脆弱であるため,この時期の環境化学物質の曝露によって,子どもの脳発達に影響を及ぼし,さまざまな異常を引き起こすことが示されてきた.初代培養系を用いたこれまでの研究から,4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl(水酸化PCB)曝露が小脳プルキンエ細胞の樹状突起の伸長に影響を及ぼすことが報告されている(Kimura-Kuroda et al., 2007).しかし低用量水酸化PCBの周産期曝露によって仔の小脳機能の発達にどのような影響を及ぼすかはあまり分かっていない.本研究では,胎仔期または授乳期に水酸化PCBを曝露したマウスを用いて,ロータロッド試験によって運動協調機能を検証し,水酸化PCB曝露が小脳機能に影響を及ぼすかについて検討した.胎仔期曝露条件では,妊娠したC57BL/6Jマウスに,コーン油に溶解した水酸化PCBを0.05または0.5 mg/kg b.w.の濃度で,妊娠10日目から18日目まで1日おきに投与した.授乳期曝露条件では,母獣にOH-PCB 106を0.05または0.5 mg/kg b.w.の濃度で,出産後3日目から13日目まで1日おきに投与した.これらの母獣の雌雄仔が成熟後にロータロッド試験を行なった.その結果,いずれの曝露条件においても,母獣の体重変化には影響がなかった.胎仔期曝露条件における産仔数や授乳期曝露による仔の死亡率も対照群と比べて有意な差はなかった.ロータロッド試験では,授乳期0.05 および0.5 mg/kg b.w.曝露群の雄仔において,試験の成績が対照群と比べて有意に低下した.このことから,水酸化PCBの曝露は,仔の小脳機能発達に影響を及ぼすことが示された.また水酸化PCBの曝露影響は,曝露時期や性によって異なることが示唆された.

    DOI CiNii

  • Fluorescence laser microdissection reveals a distinct pattern of gene activation in the mouse hippocampal region

    Wataru Yoshioka, Nozomi Endo, Akie Kurashige, Asahi Haijima, Toshihiro Endo, Toshiyuki Shibata, Ryutaro Nishiyama, Masaki Kakeyama, Chiharu Tohyama

    SCIENTIFIC REPORTS   2   783  2012年11月  [査読有り]

     概要を見る

    A histoanatomical context is imperative in an analysis of gene expression in a cell in a tissue to elucidate physiological function of the cell. In this study, we made technical advances in fluorescence laser microdissection (LMD) in combination with the absolute quantification of small amounts of mRNAs from a region of interest (ROI) in fluorescence-labeled tissue sections. We demonstrate that our fluorescence LMD-RTqPCR method has three orders of dynamic range, with the lower limit of ROI-size corresponding to a single cell. The absolute quantification of the expression levels of the immediate early genes in an ROI equivalent to a few hundred neurons in the hippocampus revealed that mice transferred from their home cage to a novel environment have distinct activation profiles in the hippocampal regions (CA1, CA3, and DG) and that the gene expression pattern in CA1, but not in the other regions, follows a power law distribution.

    DOI

  • Dissociable anterograde amnesic effects of retrosplenial cortex and hippocampal lesions on spontaneous object recognition memory in rats

    Asahi Haijima, Yukio Ichitani

    HIPPOCAMPUS   22 ( 9 ) 1868 - 1875  2012年09月  [査読有り]

     概要を見る

    The amnesic effects of excitotoxic lesions of the rat retrosplenial cortex (RS) and hippocampus (HPC) in the spontaneous object recognition (SOR) performance were investigated. The SOR test consisted of the sample-exposure session(s) and a test session. First, to test retrograde amnesia, rats received four sample-exposure sessions within a day at 4 weeks and 1 day before the surgery, respectively. In the test sessions conducted 1 week after the surgery, both lesion groups showed a temporally ungraded retrograde amnesia. Second, to test anterograde amnesia, 1- and 4-week retention intervals were inserted between the four sample-exposure sessions and the test session. The RS-lesioned rats showed a retention interval-dependent impairment in the test sessions, while the HPC-lesioned rats showed an impairment regardless of the retention interval. Finally, to test short-term recognition memory, 5- or 30-min delay was interposed between the single sample-exposure session and the test session. Both lesion groups performed normally irrespective of the delay length. These results suggest that both the RS and HPC are important for long-term object recognition memory, but these areas have different roles in it. (c) 2012 Wiley Periodicals, Inc.

    DOI

  • Executive function deficits and social-behavioral abnormality in mice exposed to a low dose of dioxin in utero and via lactation.

    Endo T, Kakeyama M, Uemura Y, Haijima A, Okuno H, Bito H, Tohyama C

    Plos One   7   :e50741, - (IF=2.766, cited by 37)  2012年  [査読有り]

     概要を見る

    2012/12/13共同通信ニュース、東京新聞、信濃毎日新聞他、12/14東奥日報、熊本日日新聞、長崎新聞、ヤフーニュース・ヘッドライン他、12/18日刊工業新聞他、12/20ナショナル・ジオグラフィック・ニュース他報道

    DOI

  • Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage

    Toshihiro Endo, Fumihiko Maekawa, Vootele Voikar, Asahi Haijima, Yukari Uemura, Yan Zhang, Wataru Miyazaki, Shigetomo Suyama, Kuniko Shimazaki, David P. Wolfer, Toshihiko Yada, Chiharu Tohyama, Hans-Peter Lipp, Masaki Kakeyama

    BEHAVIOURAL BRAIN RESEARCH   221 ( 1 ) 172 - 181  2011年08月  [査読有り]

     概要を見る

    There has been a long-standing need to develop efficient and standardized behavioral test methods for evaluating higher-order brain functions in mice. Here, we developed and validated a behavioral flexibility test in mice using IntelliCage, a fully automated behavioral analysis system for mice in a group-housed environment. We first developed a "behavioral sequencing task" in the IntelliCage that enables us to assess the learning ability of place discrimination and behavioral sequence for reward acquisition. In the serial reversal learning using the task, the discriminated spatial patterns of the rewarded and never-rewarded places were serially reversed, and thus, mice were accordingly expected to realign the previously acquired behavioral sequence. In general, the tested mice showed rapid acquisition of the behavioral sequencing task and behavioral flexibility in the subsequent serial reversal stages both in intra- and inter-session analyses. It was found that essentially the same results were obtained among three different laboratories, which confirm the high stability of the present test protocol in different strains of mice (C57BL/6, DBA/2, and ICR). In particular, the most trained cohort of C578L/6 mice achieved a markedly rapid adaptation to the reversal task in the final phase of the long-term serial reversal test, which possibly indicated that the mice adapted to the "reversal rule" itself. In conclusion, the newly developed behavioral test was shown to be a valid assay of behavioral flexibility in mice, and is expected to be utilized in tests of mouse models of cognitive deficits. (C) 2011 Elsevier B.V. All rights reserved.

    DOI

  • Development of novel behavioral toxicity tests in rodents aimed for application to health risks in humans.

    Kakeyama M, Haijima A, Endo T, Tohyama C

    The Japanese Journal of Animal Psychology   61   33 - 42  2011年  [査読有り]

    DOI

  • In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice

    Asahi Haijima, Toshihiro Endo, Yan Zhang, Wataru Miyazaki, Masaki Kakeyama, Chiharu Tohyama

    NEUROTOXICOLOGY   31 ( 4 ) 385 - 390  2010年08月  [査読有り]

     概要を見る

    Environmental-level in utero and lactational exposures to dioxins have been considered to affect brain functions of offspring. Here, we determined whether in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD), at the dose that does not harm the dams, affects the acquisition and retention of fear memory in mouse offspring. Pregnant C57BL/6J mice were administered by gavages TCDD or TBDD at a dose of 0 or 3.0 mu g/kg body weight on gestation day 12.5, and their male offspring were examined for their behavior in adulthood. In the fear conditioning, a paired presentation of tone and foot shock was repeated three times, and retention tests for contextual and auditory fear memory were carried out 1 and 24 h after the fear conditioning. Groups of mice that were exposed to TCDD and TBDD in utero and via lactation showed deficits in the contextual and auditory retention tests at 1 and 24 h retention intervals. The present results suggest that maternal exposure to a low dose of TCDD or TBDD disrupts the functions of memory and emotion in male mouse offspring, and that the developmental toxicities of these chemicals are similar to each other. (C) 2010 Elsevier Inc. All rights reserved.

    DOI

  • Perinatal exposure to a low-dose of dioxin induces deficits in fear conditioning in mice.

    Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C

    Organohalogen Compounds   71   442 - 446  2009年

  • Anterograde and retrograde amnesia of place discrimination in retrosplenial cortex and hippocampal lesioned rats

    Asahi Haijima, Yukio Ichitani

    LEARNING & MEMORY   15 ( 7 ) 477 - 482  2008年07月  [査読有り]

     概要を見る

    Retrograde and anterograde amnesic effects of excitotoxic lesions of the rat retrosplenial cortex (RS) and hippocampus (HPC) were investigated. To test retrograde amnesia, rats were trained with two-arm place discrimination in a radial maze 4 wk and 1 d before surgery with a different arm pair, respectively. In the retention test 1 wk after surgery, both lesion groups showed temporally ungraded retrograde amnesia. To test anterograde amnesia, animals were trained after surgery to discriminate three arm pairs successively within a day, and then after interposition of 1- to 4- wk intervals, one of these pairs, respectively, was tested for retention. RS-lesioned rats could acquire these pairs of place discriminations rapidly but showed a retention interval-dependent impairment in the retention test. Conversely, HPC-lesioned rats took more sessions to acquire these pairs than did the control group, and their retention was similar to 70% of correct performance regardless of retention interval. Results suggest that RS and HPC have different roles in spatial memory and that RS is important for remote memory process.

    DOI

▼全件表示

Misc

  • 周産期の軽度甲状腺機能低下により成体マウスで観察された学習障害

    天野 出月, 高鶴 裕介, Miski Aghnia Khairinisa, 小久保 倫文, 蓜島 旭, 鯉淵 典之

    The Kitakanto medical journal = 北関東医学   65 ( 4 ) 319 - 319  2015年11月

    CiNii

  • Effect of oral administration of thyroxine on cerebellar function in congenital hypothyroid(rdw)rat

    Hideka Hayashi, Anri Azuma, Hiroyuki Mizuno, Shinosuke Masuda, Yu Lu, Ronny Lesmana, Asahi Haijima, Yusuke Takatsuru, Toshiharu Iwasaki, Noriaki Shimokawa, Motoaki Umezu, Noriyuki Koibuchi

    JOURNAL OF PHYSIOLOGICAL SCIENCES   63   S214 - S214  2013年

    研究発表ペーパー・要旨(国際会議)  

特定課題研究

  • げっ歯類における視覚に基づくコミュニケーションの神経基盤の解析

    2020年  

     概要を見る

    我々は日常的に他者とコミュニケーションをとりながら生活している。中でも他者の顔や身体を適切に認知・識別する能力は,他者の性別や年齢,意図や情動などの情報を読み取るための基盤となる重要なものである。しかし,げっ歯類では匂いを中心としたものと考えられてきたため,げっ歯類における視覚的要因やそのメカニズムについてはほとんどわかっていない。本研究では,平原ハタネズミの視覚的な他個体認知能力の評価と脳機能の解析を行うことを目的として,タッチスクリーン型オペラント箱を用いて2視覚弁別課題を行なった。その結果,平原ハタネズミが同種他個体個体を弁別できる可能性が示唆された。

  • マウスの記憶想起におよぼす経験の影響の解析

    2019年  

     概要を見る

    検索誘導性忘却(RIF)は,ある事柄を思い出すことを経験すると,それに関連した記憶が抑制される現象である。経験が記憶の想起に及ぼす影響を明らかにすることは、記憶メカニズムを解明するために重要な課題である。しかし記憶の神経基盤の解析に有用なマウスにおいてRIFに関する研究はほとんど行われてこなかった。そこで本研究では,マウスにおいてRIFは雌雄共に生じるのか,また若齢期および老齢期のマウスにおいてRIFが生じるかについて,新奇物体再認記憶試験を改変した行動試験を用いて検討した。その結果,RIFはマウスにおいて雌雄ともに生じること,若齢期から老齢期まで保持されることが示唆された。

 

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