Updated on 2022/05/25

写真a

 
ZHU, Xiaodong
 
Affiliation
Faculty of Science and Engineering, Waseda Research Institute for Science and Engineering
Job title
Research Associate

Education

  • 2014.09
    -
    2017.09

    Waseda University   Graduate School of Creative Science and Engineering   Department of Modern Mechanical Engineering  

    Doctor

  • 2012.09
    -
    2014.09

    Waseda University   Graduate School of Creative Science and Engineering   Department of Modern Mechanical Engineering  

    Master

  • 2005.09
    -
    2009.07

    Shanghai University   School of Mechatronic Engineering and Automation  

    Bachelor

Research Experience

  • 2011.07
    -
    2012.09

    Fuji International Language Institute

  • 2009.09
    -
    2011.05

    DISCO HI-TEC CHINA CO., LTD.   Department of technology   Customer Engineer

Professional Memberships

  • 2017.05
    -
    Now

    Japanese society of biorheology

  • 2016.12
    -
    Now

    SOCIETY FOR REGULATORY SCIENCE OF MEDICAL PRODUCTS

  • 2014.06
    -
    Now

    The Japan Society of Mechanical Engineers

 

Research Areas

  • Biomedical engineering

Research Interests

  • Coronary disease

  • Coronary stent

  • Finite element analysis

  • 3D medical imaging measurement

  • Cutting balloon

Papers

  • Study on Expansion Performance of Calcified Coronary Arteries by Finite Element Modeling and Analysis of a Balloon with Blades

    Xiaodong ZHU

       2021.07

    Authorship:Lead author, Corresponding author

  • Finite element analysis of cutting balloon expansion in a calcified artery model of circular angle 180°: Effects of balloon-to-diameter ratio and number of blades facing calcification on potential calcification fracturing and perforation reduction

    Xiaodong Zhu, Mitsuo Umezu, Kiyotaka Iwasaki

    PLOS ONE   16 ( 5 ) e0251404 - e0251404  2021.05  [Refereed]

    Authorship:Lead author

     View Summary

    Calcified artery lesions cause stent under-expansion and increase the risk of in-stent restenosis and stent thrombosis. Cutting balloons facilitate the fracturing of calcification prior to stent implantation, although vessel dissection and perforation are potential issues. In clinical practice, calcifications having maximum calcium angles ≤ 180° are rarely fractured during conventional balloon angioplasty. We hypothesize that the lesion/device diameter ratio and the number of blades facing a non-circular calcified lesion may be crucial for fracturing the calcification while avoiding vessel injury. The geometries of the cutting balloons were constructed and their finite-element models were generated by folding and wrapping the balloon model. Numerical simulations were performed for balloons with five different diameters and two types of blade directions in a 180° calcification model. The calcification expansion ability was distinctly higher when two blades faced the calcification than when one blade did. Moreover, when two blades faced the calcification model, larger maximum principal stresses were generated in the calcification even when using undersized balloons with diameters reduced by 0.25 or 0.5 mm from the reference diameter, when compared with the case where one blade faced the calcified model and a balloon of diameter equal to the reference diameter was used. When two blades faced the calcification, smaller stresses were generated in the artery adjacent to the calcification; further, the maximum stress generated in the artery model adjacent to the calcification under the rated pressure of 12 atm when employing undersized balloons was smaller than that when only one blade faced the calcification and when lesion-identical balloon diameters were used under a nominal pressure of 6 atm. Our study suggested that undersized balloons of diameters 0.25 or 0.5 mm less than the reference diameter might be effective in not only expanding the calcified lesion but also reducing the risk of dissection.

    DOI

  • Finite Element Analysis of the Cutting Balloon With an Adequate Balloon-to-Artery Ratio for Fracturing Calcification While Preventing Perforation

    Xiaodong Zhu, Mitsuo Umezu, Kiyotaka Iwasaki

    Circulation Reports   3 ( 1 ) 1 - 8  2021.01  [Refereed]  [Domestic journal]

    Authorship:Lead author

     View Summary

    Background:
    The appropriate balloon-to-artery ratio (BAR) for cutting balloons (CBs), to expand calcified lesions without increasing the risk of coronary artery perforation is unknown. This study investigated the effects of BAR on stress levels in the calcification and at the borders of the coronary artery adjacent to the calcification to determine an appropriate BAR.
    Methods and Results:
    A custom-designed folding process of the CB model was developed. The CB models were deployed in a coronary artery model with a reference diameter of 3.0 mm, length of 24 mm, and wall thickness of 0.8 mm equipped with a 50% diameter stenotic, 360° concentric, 400-µm, and 5-mm-long calcification. Finite element analysis of the expansion of CBs with diameters increasing from 2.0 to 3.0 mm in 0.25-mm increments, corresponding to BARs from 0.67 : 1 to 1 : 1, was conducted with pressures up to 12 atm. Decreasing the CB by 0.25 and 0.5 mm (relative to the reference diameter of 3 mm) preserved maximum principal tensile stress levels comparable to that of a CB with a BAR of 1 : 1 while distinctly reducing the stress at the border of the artery adjacent and calcification.
    Conclusions:
    Selecting a CB that is 0.25 or 0.5 mm lower than the 3-mm reference diameter may be the first choice to effectively fracture calcifications without increasing the risk of severe artery dissection and perforation.

    DOI PubMed

  • Three-Dimensional Strain Measurements of a Tubular Elastic Model Using Tomographic Particle Image Velocimetry

    Azuma Takahashi, Xiaodong Zhu, Yusuke Aoyama, Mitsuo Umezu, Kiyotaka Iwasaki

    Cardiovascular Engineering and Technology   9 ( 3 ) 395 - 404  2018.09  [Refereed]  [International journal]

     View Summary

    The evaluation of strain induced in a blood vessel owing to contact with a medical device is of significance to examine the causes leading to vascular injury and rupture. The development of a method to assess strain in largely deformed elastic materials is expected. This study's scope was to measure strain in deformed tubular elastic mock vessels using tomographic particle image velocimetry (tomo-PIV), and to show the applicability of this measurement method by comparing the results with data derived from a finite element analysis (FEA). Strain distribution was calculated from the displacement distribution, which in turn was measured by tracking fluorescent 13 μm particles in a transparent tubular elastic model using tomo-PIV. The von Mises strain distribution was calculated for a model whose inner diameter was subjected to a pressure load, because of which it expanded from 25 to 27.5 mm, adjusting to the diameter change of a human aorta during heartbeat. An FEA simulating the experiment was also conducted. Three-dimensional strain was successfully measured by using the tomo-PIV method. The radial strain distribution in the model linearly decreased outward (from the its inner to its outer side), and the result was consistent with the data obtained from the FEA. The mean von Mises strain measured using tomo-PIV was comparable with that obtained from the FEA (tomo-PIV: 0.155, FEA: 0.156). This study demonstrates the feasibility of utilizing tomo-PIV to quantitatively assess the three-dimensional strain induced in largely deformed elastic models.

    DOI PubMed

Misc

  • Dk-Crush Stenting Increases the Risk of Incomplete Stent Apposition Compared With Culotte Stenting for the Treatment of Left Main Coronary Bifurcation Lesion: Analysis From Micro CT

    Yutaka Hikichi, Kaito Matsubara, Kouta Sugiyama, Xiaodong Zhu, Yusuke Tsuboko, Yuki Matsuhashi, Yohei Inoue, Masahiro Natsuaki, Koichi Node, Kiyotaka Iwasaki

    CIRCULATION   140  2019.11

    Research paper, summary (international conference)  

     View Summary

    0

  • Experimental investigation of influence of stent designs and sizes on stent apposition using a left main coronary artery bifurcation model

    松原海斗, 挽地裕, 杉山航太, 伊藤遼太, ZHU Xiaodong, 坪子侑佑, 松橋祐輝, 梅津光生, 岩崎清隆

    バイオエンジニアリング講演会講演論文集(CD-ROM)   32nd  2019

    J-GLOBAL

  • C110 Stress analysis on superficial femoral artery deployed with a self-expandable Nitinol stent

    TOKUTAKE Hirotsugu, IWASAKI Kiyotaka, ZHU Xiaodong, UMEZU Mitsuo

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering   2014 ( 25 ) 77 - 78  2014.10

    CiNii

  • C109 Finite element analysis on the influence of cyclic bend angles on coronary stent fracture

    ZHU Xiaodong, IWASAKI Kiyotaka, TOKUTAKE Hirotsugu, UMEZU Mitsuo

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering   2014 ( 25 ) 75 - 76  2014.10

    CiNii

  • 2D32 Experimental analysis on influence of angular amplitude on fracture resistance of the coronary stents using an accelerated bend-load durability tester

    ARAI Jun, IWASAKI Kiyotaka, ZHU Xiaodong, OBA Takafumi, TOKUTAKE Hirotsugu, YAMAMOTO Tadashi, HIKICHI Yutaka, UMEZU Mitsuo

      2014 ( 26 ) 413 - 414  2014.01

    CiNii

  • A213 Development of a bend-load durability tester for evaluating fracture resistance of endovascular stents

    Arai Jun, IWASAKI Kiyotaka, ZHU Xiaodong, OBA Takafumi, TOKUTAKE Hirotsugu, YAMAMOTO Tadashi, HIKICHI Yutaka, UMEZU Mitsuo

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering   2013 ( 24 ) 73 - 74  2013.10

    CiNii

▼display all

Awards

  • Incentive Award

    2021.07   the 44th annual meeting of the Japanese Society of Biorheology  

  • ライフサポート学会奨励賞

    2020.03   第29回ライフサポート学会フロンティア講演会   生体内腐食環境下におけるマグネシウム合金製生体吸収性スキャフォールドの繰り返し屈曲運動に対する破断耐久性に関する研究

    Winner: 杉山航太, 石綱ゆうみ, 松原海斗, 伊藤僚太, 陳澤宇, 朱暁冬, 梅津光生, 岩﨑清隆

  • Young Presentation Award

    2015.09   LIFE2015  

  • JSME Young Fellow Award

    2015.01   25th JSME Conference on Frontiers in Bioengineering  

  • Young Presentation Award

    2014.09   LIFE2014  

Presentations

  • 半周性石灰化病変血管モデルのカッティングバルーンによる拡張に関する有限要素解析

    朱暁冬, 岩﨑清隆

    第44回日本バイオレオロジー学会年会 

    Presentation date: 2021.07

  • Investigation of fracturing capability devices against calcification by a model

    K. Murakami, Y. Ishizuna, R. Ito, X. Zhu, K. Iwasaki

    EURO PCR 2021 

    Presentation date: 2021.05

  • Influence of Stent Design on Expansion of Calcified Lesions afterFracturing Calcification Using Lesion Preparation Devices

    R. Ito, Y. Ishizuna, X. Zhu, Z. Chen, K. Iwasaki

    EMBC2020 

    Presentation date: 2020.07

  • 左冠動脈主幹部分岐病変におけるステントのデザインとサイズが圧縮性に及ぼす影響の実験的検討

    松原海斗, 挽地裕, 杉山航太, 伊藤遼太, 朱暁冬, 坪子侑佑, 松橋祐輝, 梅津光生, 岩﨑清隆

    日本機械学会第32回バイオエンジニアリング講演会 

    Presentation date: 2019.12

  • Experimental Investigation of the Influence of Stent Design on Jailed Struts and Stent Malapposition Using a Left Main Coronary Artery Model

    K.Matsubara, Y. Hikichi, K. Sugiyama, R. Ito, X. Zhu, Y. Tsuboko, Y. Matsuhashi, M. Umezu, K. Iwasaki

    ICBME2019 

    Presentation date: 2019.12

  • Development of Calcification Models for Investigating Fracturing Performances of Coronary Lesion Modification Devices

    R. Ito, X. Zhu, K. Matsubara, K. Sugiyama, Z. Chen, Y. Ishizuna, M. Umezu, K. Iwasaki

    ICBME2019 

    Presentation date: 2019.12

  • 先進的医療機器の効率的開発を促進する患者を模した非臨床試験系の開発

    岩﨑清隆, 松橋祐輝, 坪子侑佑, 朱暁冬, 高田淳平, 笠貫宏, 梅津光生

    第58回日本生体医工学会大会 

    Presentation date: 2019.06

  • 腸骨静脈ステントの性能評価のためのブタ腹部大静脈の力学的特性の取得と加速耐久試験装置の開発

    湯本幹基, 杉山航太, 松原海人, 伊藤遼太, 朱暁冬, 梅津光生, 岩﨑清隆

    第42回日本バイオレオロジー学会年会 

    Presentation date: 2019.06

  • Influences of thickness and circumferential angles of calcification on the capability of fracturing calcification of the cutting balloon: an experimental investigation

    R. Ito, X. Zhu, K. Matsubara, K. Sugiyama, M. Yumoto, M. Umezu, K. Iwasaki

    Euro PCR 2019 

    Presentation date: 2019.05

  • Experimental investigation of influence of stent designs on jailed struts and flow using a left main coronary artery model

    K. Matsubara, Y. Hikichi, K. Sugiyama, X. Zhu, Y. Tsuboko, Y. Matsuhashi, R. Ito, K. Iwasaki

    Euro PCR 2019 

    Presentation date: 2019.05

  • 実臨床を模した先進的非臨床試験法の開発と活用

    岩﨑清隆, 山崎健二, 加瀬川均, 松橋祐輝, 高田淳平, 朱暁冬, 梅津光生

    第56回日本人工臓器学会大会 

    Presentation date: 2018.11

  • 浅大腿動脈でのねじり伸縮複合負荷環境における重複留置したステントの破断耐久性に関する研究

    水谷泰之, 松原海斗, 杉山航太, 湯本幹基, 伊藤遼太, 朱暁冬, 梅津光生, 岩﨑清隆

    日本機械学会第29回バイオフロンティア講演会 

    Presentation date: 2018.10

  • 生体吸収性スキャフォールドのデザインと破断耐久性に関する研究

    水谷泰之, 和泉恒平, 杉山航太, 松原海斗, 伊藤遼太, 湯本幹基, 朱暁冬, 梅津光生, 岩﨑清隆

    LIFE 2018(第34回ライフサポート学会 第18回日本生活支援工学会大会 日本機械学会 福祉工学シンポジウム2018) 

    Presentation date: 2018.09

  • 左冠動脈主幹部分岐病変におけるステントのコネクターとデザインが流れに及ぼす影響

    松原海斗, 水谷泰之, 朱暁冬, 杉山航太, 挽地裕, 梅津光生, 岩﨑清隆

    LIFE 2018(第34回ライフサポート学会 第18回日本生活支援工学会大会 日本機械学会 福祉工学シンポジウム2018) 

    Presentation date: 2018.09

  • Finite element analysis of potential migration of a stent graft into thoracic aotic aneurysm

    J. Kozaki, X. Zhu, K. Shukuzawa, M. Umezu

    EMBC 2018 

    Presentation date: 2018.07

  • Finite element analysis on expansion of cutting balloon in calcified coronary artery in comparison with conventional balloon

    X. Zhu, M. Umezu, K. Iwasaki

    EMBC 2018 

    Presentation date: 2018.07

  • 先進的非臨床試験法開発と国際標準化,グローバル展開

    岩﨑清隆, 松橋祐輝, 坪子侑佑, 朱暁冬, 笠貫宏, 梅津光生

    第57回日本生体医工学会大会 

    Presentation date: 2018.06

  • Micro-CT analysis of DK crush stenting vs. culotte stenting for left main distal bifurcation lesions: using three dimensional left main elastic bifurcated coronary artery models

    Y. Hikichi, G. Hongo, T. Kaneko, Y. Inoue, M. Natsuaki, Y. Mizutani, K. Matsubara, X. Zhu, K. Sugiyama, K. Node, K. Iwasaki

    EURO PCR 2018 The World-Leading Course in Interventional Cardiovascular Medicine 

    Presentation date: 2018.05

  • Finite element amalysis of the radial artery compression devices to investigate relationships between an inflation volume and compression pressure of wrist tissue

    X. Zhu, Y. Mizutani, M. Umezu, K. Iwasaki

    CMBBE 2018 

    Presentation date: 2018.03

  • Finite element analysis on the influence of distance between anterior and posterior papillary muscles on the stress distribution of the stentless mitral valve at closure

    J. Takada, X. Zhu, K. Mahara, H. Kasegawa, M.Umezu, K. Iwasaki

    CMBBE 2018 

    Presentation date: 2018.03

  • 生体吸収性スキャフォールドの経時的拡張保持特性と分解特性に関する研究

    水谷泰之, 和泉恒平, 高橋啓明, 松原海斗, 杉山航太, 朱暁冬, 梅津光生, 岩﨑清隆

    日本機械学会第30回バイオエンジニアリング講演会 

    Presentation date: 2017.12

  • 粒子イメージ流速計測法を用いたステントデザインが分岐狭窄病変における血流に及ぼす影響の検討

    水谷泰之, 松原海斗, 朱暁冬, 鮫島啓, 杉山航太, 挽地裕, 梅津光生, 岩﨑清隆

    日本機械学会第28回バイオフロンティア講演会 

    Presentation date: 2017.10

  • 有限要素法を用いた屈曲変形時における冠動脈ステントの応力解析

    朱暁冬, 梅津光生, 岩﨑清隆

    日本機械学会2017年度年次大会 

    Presentation date: 2017.09

  • Normo弁の性能試験:拍動流性能と応力解析

    高田淳平, 加瀬川均, 馬原啓太郎, 朱暁冬, 熊澤亮, 梅津光生, 岩﨑清隆

    第6回ステントレス僧帽弁臨床研究学術集会 

    Presentation date: 2017.09

  • Finite Element Analysis of Self-Expanding Nitinol Stent under Torsion and Shortening Conditions of superficial femoral Artery

    X. Zhu, M. Umezu, K Iwasaki

    39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 

    Presentation date: 2017.07

  • 浅大腿動脈のねじり短縮複合負荷に対する自己拡張型Ni-Ti合金製ステントの有限要素解析

    朱暁冬, 橋本雅也, 梅津光生, 岩﨑清隆

    第40回日本バイオレオロジー学会年会 

    Presentation date: 2017.05

  • Investigation of an optimal deployment method of polymer BRS to gain acute expansion using a stenotic mechanically-equivalent coronary artery model

    Y. Mizutani, K. Izumi, X. Zhu, M. Umezu, K. Iwasaki

    EURO PCR 2017 The World-Leading Course in Interventional Cardiovascular Medicine 

    Presentation date: 2017.05

  • 乳頭筋位置が腱索機能を有するステントレス僧帽弁の応力分布に及ぼす影響に関する有限要素解析

    高田淳平, 朱暁冬, 臼井一晃, 馬原啓太郎, 加瀬川均, 梅津光生

    日本機械学会第29回バイオエンジニアリング講演会 

    Presentation date: 2017.01

  • 有限要素法を用いた前後乳頭筋間距離がNormo弁の応力分布に与える影響の評価

    高田淳平, 朱暁冬, 臼井一晃, 加瀬川均, 岩崎清隆, 梅津光生

    非線形解析フォーラム2016 

    Presentation date: 2016.11

  • 冠動脈屈曲変形時にステントに生じる応力解析方法の構築:疲労破断予測に向けて

    朱暁冬, 岩崎清隆, 梅津光生

    非線形解析フォーラム2016 

    Presentation date: 2016.11

  • ヒト左心室モデルを有する拍動循環シミュレータを用いたNormo弁の拍動動態に関する研究

    岩﨑清隆, 加瀬川均, 臼井一晃, 高田淳平, 朱暁冬, 梅津光生

    第5回ステントレス僧帽弁臨床研究会学術集会 

    Presentation date: 2016.09

  • 複合負荷の作用する大腿膝窩動脈へ留置した自己拡張型Ni-Ti合金製ステントの疲労解析

    徳武祐諭, 岩﨑清隆, 朱暁冬, 梅津光生

    日本機械学会第28回バイオエンジニアリング講演会 

    Presentation date: 2016.01

  • 狭窄を有する下肢浅大腿動脈に事項拡張型ステントを適用時に生じる応力解析

    徳武祐論, 岩﨑清隆, 朱暁冬, 梅津光生

    第31回ライフサポート学会 

    Presentation date: 2015.09

  • 有限要素法を用いた繰り返し屈曲変形が冠動脈ステントの破断に及ぼす影響の検討

    朱暁冬, 岩﨑清隆, 徳武祐論, 梅津光生

    日本機械学会第25回バイオフロンティア講演会 

    Presentation date: 2014.10

  • 自己拡張型Ni-Ti合金製ステントを留置した浅大腿動脈の応力解析

    徳武祐論, 岩﨑清隆, 朱暁冬, 梅津光生

    日本機械学会第25回バイオフロンティア講演会 

    Presentation date: 2014.10

  • 繰り返し屈曲変形の角度変化量が冠動脈ステントの破断に及ぼす影響の有限要素法解析

    朱暁冬, 岩﨑清隆, 徳武祐論, 梅津光生

    LIFE2014 生活生命支援医療福祉工学系学会連合大会 

    Presentation date: 2014.09

  • 冠動脈屈曲病変変形を模擬した屈曲負荷環境における冠動脈ステントの応力解析方法の構築

    朱暁冬, 岩﨑清隆, 新井淳, 大場貴文, 徳武祐論, 梅津光生

    第53回日本生体医工学大会 

    Presentation date: 2014.06

  • 屈曲負荷型加速耐久試験装置による屈曲角度変化量が冠動脈ステントの破損耐久性に及ぼす影響の検討

    新井淳, 岩﨑清隆, 朱暁冬, 大場貴文, 徳武祐論, 山本匡, 挽地裕, 梅津光生

    日本機械学会第26回バイオエンジニアリング講演会 

    Presentation date: 2014.01

  • 下肢血管ステントの破損耐久性評価のための屈曲負荷型耐久試験装置の開発

    新井淳, 岩﨑清隆, 朱暁冬, 大場貴文, 徳武祐論, 山本匡, 挽地裕, 梅津光生

    日本機械学会第24回バイオフロンティア講演会 

    Presentation date: 2013.11

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Specific Research

  • ブレード付バルーンを用いた高度石灰化病変の拡張性能評価に関する研究

    2018  

     View Summary

    We aimed to investigate the influence on the expansion of cutting balloon with different sizes in coronary artery with calcified plaque by finite element analysis.The finite element models of blade, pad, balloon, calcified plaque (arc 180deg) and artery were generated. First, the balloon model was crimped and compressed to obtain the folded shape and then three sets of blade models and pad models were constrained to the surface of the balloon model. Next, the whole cutting balloon model was assembled in the calcified artery model and pressure was applied to the inner surface of the balloon model. Different sizes of balloon diameter with two types of blade direction (type1: one blade inside plaque and type 2: two blades inside plaque) were considered and simulated. The maximum stresses in the plaque models in type2 were greater than those in type 1. However, in contrast the maximum principal tensile stresses occurred in artery models in type1 were larger than those in type 2. These results indicated that type 2 is more effective and safer than type1 associated with the blade direction during cutting balloon inflation. It showed that the risk of dissection is high between the plaque and artery wall.

 

Teaching Experience

  • 理工学基礎実験1B

    早稲田大学  

    2018.09
    -
    2019.09
     

  • 理工学基礎実験2A

    早稲田大学  

    2017.10
    -
    2019.03