Updated on 2023/12/04

写真a

 
ZHU, Xiaodong
 
Affiliation
Faculty of Science and Engineering, Waseda Research Institute for Science and Engineering
Job title
Junior Researcher(Assistant Professor)
Degree
Ph.D in Engineering ( 2021.07 Waseda University )

Research Experience

  • 2022.10
    -
    Now

    Waseda University   Research Institute for Science and Engineering   Junior Researcher

  • 2020.04
    -
    2022.09

    Waseda University   Research Institute for Science and Engineering   Research associate

  • 2017.10
    -
    2020.03

    Waseda University   School of Creative Science and Engineering   Research associate

  • 2011.07
    -
    2012.09

    Fuji International Language Institute

  • 2009.09
    -
    2011.05

    DISCO HI-TEC CHINA CO., LTD.   Department of technology   Customer Engineer

Education Background

  • 2014.09
    -
    2017.09

    Waseda University   Graduate School of Creative Science and Engineering   Department of Modern Mechanical Engineering  

    Doctor

  • 2012.09
    -
    2014.09

    Waseda University   Graduate School of Creative Science and Engineering   Department of Modern Mechanical Engineering  

    Master

  • 2005.09
    -
    2009.07

    Shanghai University   School of Mechatronic Engineering and Automation  

    Bachelor

Professional Memberships

  • 2017.06
    -
    Now

    Institute of Electrical and Electronics Engineers

  • 2017.05
    -
    Now

    Japanese society of biorheology

  • 2016.12
    -
    Now

    SOCIETY FOR REGULATORY SCIENCE OF MEDICAL PRODUCTS

  • 2014.06
    -
    Now

    The Japan Society of Mechanical Engineers

Research Areas

  • Measurement engineering / Mechanics of materials and materials / Biomedical engineering

Research Interests

  • Coronary disease

  • Coronary stent

  • Finite element analysis

  • 3D medical imaging measurement

  • Cutting balloon

Awards

  • Distinguished Paper Award

    2022.07   Finite element analysis of cutting balloon expansion in a calcified artery model of circular angle 180°: Effects of balloon-to-diameter ratio and number of blades facing calcification on potential calcification fracturing and perforation reduction

  • Incentive Award

    2021.07   the 44th annual meeting of the Japanese Society of Biorheology  

  • ライフサポート学会奨励賞

    2020.03   第29回ライフサポート学会フロンティア講演会   生体内腐食環境下におけるマグネシウム合金製生体吸収性スキャフォールドの繰り返し屈曲運動に対する破断耐久性に関する研究

    Winner: 杉山航太, 石綱ゆうみ, 松原海斗, 伊藤僚太, 陳澤宇, 朱暁冬, 梅津光生, 岩﨑清隆

  • Young Presentation Award

    2015.09   LIFE2015  

  • JSME Young Fellow Award

    2015.01   25th JSME Conference on Frontiers in Bioengineering  

  • Young Presentation Award

    2014.09   LIFE2014  

▼display all

 

Papers

  • Importance of optimal rewiring guided by 3-dimensional optical frequency domain imaging during double-kissing culotte stenting demonstrated through a novel bench model

    Takayuki Okamura, Kiyotaka Iwasaki, Hongze Lu, Xiaodong Zhu, Tatsuhiro Fujimura, Norika Kitaba, Keisuke Murakami, Ryota Nakamura, Haruki Mitsui, Yusuke Tsuboko, Yousuke Miyazaki, Tetsuya Matsuyama

    Scientific Reports   13 ( 1 )  2023.08  [Refereed]

     View Summary

    Abstract

    The usefulness of optical frequency domain imaging (OFDI) guidance on two-stenting at left main bifurcation has not been evaluated. Here, we used a novel bench model to investigate whether pre-defined optimal rewiring with OFDI-guidance decreases acute incomplete stent apposition (ISA) at the left main bifurcation segment. A novel bench simulation system was developed to simulate the foreshortening and overlapping of daughter vessels as well as left main bifurcation motion under fluoroscopy. Double-kissing (DK) culotte stenting was performed using the novel bench model under fluoroscopy with or without OFDI-guidance. In the OFDI-guidance group, if the guidewire did not pass through the pre-defined optimal cell according to the 3-dimensional OFDI, additional attempts of rewiring into the jailed side branch were performed. The success rate of optimal jailed side branch rewiring after implantation of the first and second stent under OFDI-guidance was significantly higher than that under only angio-guidance. After completion of the DK-culotte stenting, the incidence and volume of ISA at the bifurcation segment in the OFDI-guidance group was significantly lower than that in the angio-guidance group. Online 3-dimensional OFDI-guided DK-culotte stenting according to a pre-defined optimal rewiring point might be superior to only angio-guided rewiring for reducing ISA at the bifurcation.

    DOI

  • Biaxial tensile testing system for measuring mechanical properties of both sides of biological tissues

    Jumpei Takada, Kohei Hamada, Xiaodong Zhu, Yusuke Tsuboko, Kiyotaka Iwasaki

    Journal of the Mechanical Behavior of Biomedical Materials   146   106028 - 106028  2023.07  [Refereed]

    DOI

  • Study on Expansion Performance of Calcified Coronary Arteries by Finite Element Modeling and Analysis of a Balloon with Blades

    Xiaodong ZHU

       2021.07

    Authorship:Lead author, Corresponding author

  • Finite element analysis of cutting balloon expansion in a calcified artery model of circular angle 180°: Effects of balloon-to-diameter ratio and number of blades facing calcification on potential calcification fracturing and perforation reduction

    Xiaodong Zhu, Mitsuo Umezu, Kiyotaka Iwasaki

    PLOS ONE   16 ( 5 ) e0251404 - e0251404  2021.05  [Refereed]  [International journal]

    Authorship:Lead author

     View Summary

    Calcified artery lesions cause stent under-expansion and increase the risk of in-stent restenosis and stent thrombosis. Cutting balloons facilitate the fracturing of calcification prior to stent implantation, although vessel dissection and perforation are potential issues. In clinical practice, calcifications having maximum calcium angles ≤ 180° are rarely fractured during conventional balloon angioplasty. We hypothesize that the lesion/device diameter ratio and the number of blades facing a non-circular calcified lesion may be crucial for fracturing the calcification while avoiding vessel injury. The geometries of the cutting balloons were constructed and their finite-element models were generated by folding and wrapping the balloon model. Numerical simulations were performed for balloons with five different diameters and two types of blade directions in a 180° calcification model. The calcification expansion ability was distinctly higher when two blades faced the calcification than when one blade did. Moreover, when two blades faced the calcification model, larger maximum principal stresses were generated in the calcification even when using undersized balloons with diameters reduced by 0.25 or 0.5 mm from the reference diameter, when compared with the case where one blade faced the calcified model and a balloon of diameter equal to the reference diameter was used. When two blades faced the calcification, smaller stresses were generated in the artery adjacent to the calcification; further, the maximum stress generated in the artery model adjacent to the calcification under the rated pressure of 12 atm when employing undersized balloons was smaller than that when only one blade faced the calcification and when lesion-identical balloon diameters were used under a nominal pressure of 6 atm. Our study suggested that undersized balloons of diameters 0.25 or 0.5 mm less than the reference diameter might be effective in not only expanding the calcified lesion but also reducing the risk of dissection.

    DOI PubMed

  • Finite Element Analysis of the Cutting Balloon With an Adequate Balloon-to-Artery Ratio for Fracturing Calcification While Preventing Perforation

    Xiaodong Zhu, Mitsuo Umezu, Kiyotaka Iwasaki

    Circulation Reports   3 ( 1 ) 1 - 8  2021.01  [Refereed]  [Domestic journal]

    Authorship:Lead author

     View Summary

    Background:
    The appropriate balloon-to-artery ratio (BAR) for cutting balloons (CBs), to expand calcified lesions without increasing the risk of coronary artery perforation is unknown. This study investigated the effects of BAR on stress levels in the calcification and at the borders of the coronary artery adjacent to the calcification to determine an appropriate BAR.
    Methods and Results:
    A custom-designed folding process of the CB model was developed. The CB models were deployed in a coronary artery model with a reference diameter of 3.0 mm, length of 24 mm, and wall thickness of 0.8 mm equipped with a 50% diameter stenotic, 360° concentric, 400-µm, and 5-mm-long calcification. Finite element analysis of the expansion of CBs with diameters increasing from 2.0 to 3.0 mm in 0.25-mm increments, corresponding to BARs from 0.67 : 1 to 1 : 1, was conducted with pressures up to 12 atm. Decreasing the CB by 0.25 and 0.5 mm (relative to the reference diameter of 3 mm) preserved maximum principal tensile stress levels comparable to that of a CB with a BAR of 1 : 1 while distinctly reducing the stress at the border of the artery adjacent and calcification.
    Conclusions:
    Selecting a CB that is 0.25 or 0.5 mm lower than the 3-mm reference diameter may be the first choice to effectively fracture calcifications without increasing the risk of severe artery dissection and perforation.

    DOI PubMed

  • 先進的医療機器の効率的開発を促進する患者を模した非臨床試験系の開発

    岩崎 清隆, 松橋 祐輝, 坪子 侑佑, 朱 暁冬, 高田 淳平, 笠貫 宏, 梅津 光生

    生体医工学   Annual57 ( Abstract ) S13_2 - S13_2  2019

     View Summary

    先進技術の結集からなる医療機器は、これまで治療が困難であった患者さんの治療、そして、医療の発展に大きく貢献している。革新的医療機器の開発の成功確率が高いとは言えず長い開発期間を要する。最先端の医療機器を開発し、患者さんに迅速に届けるためには、技術開発に加え、安全性と期待される有効性の科学的・合理的評価が必須である。しかし、既存の評価方法では、新しい医療技術の評価に限界があり、そのまま患者さんによる臨床試験を行なう場合にはリスク予測が困難になる問題に直面する。我々は、病態のモデル化技術を実験・シミュレーション技術を発展させ、患者を模したこれまでにない試験システムを開発して有効性と安全性の評価方法の開発に取り組み、開発の効率化、そして、行政における決断の科学的根拠に活用される研究を推進している。また、特に医療機器では医師の治療手技も治療成績向上に重要であり、治療方法がない患者さんに対する効果的治療法の開発に取り組んでいる。現場の最前線で治療に挑んでいる医師との多くの共同研究により明日の実臨床を良くする研究成果を積み上げており、本講演では、最新の我々の取り組みについて紹介する。

    DOI CiNii

  • Three-Dimensional Strain Measurements of a Tubular Elastic Model Using Tomographic Particle Image Velocimetry

    Azuma Takahashi, Xiaodong Zhu, Yusuke Aoyama, Mitsuo Umezu, Kiyotaka Iwasaki

    Cardiovascular Engineering and Technology   9 ( 3 ) 395 - 404  2018.09  [Refereed]  [International journal]

     View Summary

    The evaluation of strain induced in a blood vessel owing to contact with a medical device is of significance to examine the causes leading to vascular injury and rupture. The development of a method to assess strain in largely deformed elastic materials is expected. This study's scope was to measure strain in deformed tubular elastic mock vessels using tomographic particle image velocimetry (tomo-PIV), and to show the applicability of this measurement method by comparing the results with data derived from a finite element analysis (FEA). Strain distribution was calculated from the displacement distribution, which in turn was measured by tracking fluorescent 13 μm particles in a transparent tubular elastic model using tomo-PIV. The von Mises strain distribution was calculated for a model whose inner diameter was subjected to a pressure load, because of which it expanded from 25 to 27.5 mm, adjusting to the diameter change of a human aorta during heartbeat. An FEA simulating the experiment was also conducted. Three-dimensional strain was successfully measured by using the tomo-PIV method. The radial strain distribution in the model linearly decreased outward (from the its inner to its outer side), and the result was consistent with the data obtained from the FEA. The mean von Mises strain measured using tomo-PIV was comparable with that obtained from the FEA (tomo-PIV: 0.155, FEA: 0.156). This study demonstrates the feasibility of utilizing tomo-PIV to quantitatively assess the three-dimensional strain induced in largely deformed elastic models.

    DOI PubMed

  • Prediction of fatigue failure of coronary stent under cyclic bend loading using finite element analysis

    IWASAKI KIYOTAKA, ZHU Xiaodong, TOKUTAKE Hirotsugu, UMEZU Mitsuo

    Transactions of Japanese Society for Medical and Biological Engineering   53   S136_01 - S136_01  2015

     View Summary

    Introduction: Coronary stent fracture is recognized as causes of restenosis or thrombosis. We conducted finite element analysis (FEA) of coronary stent to predict fatigue failure under cyclic bend loading. Methods: Matched with manufacturing steps of coronary stent, a stent with a diameter, length and thickness of 1.8mm, 18mm, and 81μm was modeled. The stent was crimped on a balloon by applying enforced displacement until the outer diameter became 1.0mm. Next, the stent was deployed into a bended coronary artery model with an angulation of 125 degrees. Then, cyclic bend from 125 degrees to 105 degrees was applied to the stent. Results and Discussions: FEA of alternating stress, mean stress, and fatigue safety factor showed that there were nodes in unsafe zone in Goodman diagram. FEA suggested a threshold of cyclic bend angulation of the coronary stent on fatigue failure. Fracture locations observed in the cyclic-bend accelerated durability tests was consistent with the nodes of the stents which exceeded fatigue safety factor of 1. Conclusion: The comparison between FEA and accelerated durability tests indicated that FEA was useful to predict fatigue failure of the coronary stent.layer and gas layer.

    DOI CiNii

  • Angulation Range of Coronary Artery During the Cardiac Cycles is a Key Factor Inducing Stent Fracture; Demonstration by an in vitro Accelerated Durability Test

    Kiyotaka Iwasaki, Jun Arai, Takafumi Ohba, Hirotsugu Tokutake, Zhu Xiaodong, Mitsuo Umezu

    CIRCULATION   130  2014.11  [Refereed]

  • Fracture Potentials and Dynamic Flexibility of Peripheral Stents: Insights into Clinical Practice From Durability Tests Simulating Multi-loading Environments of Superficial Femoral and Popliteal Arteries

    Iwasaki Kiyotaka, Kishigami Sho, Arai Jun, Ohba Takafumi, Tokutake Hirotsugu, Zhu Xiaodong, Yagishita Yuichi, Noguchi Yusuke, Yamamoto Tadashi, Hikichi Yutaka, Umezu Mitsuo

    CIRCULATION   128 ( 22 )  2013.11  [Refereed]

  • Flexibility and Stent Fracture Potentials Against Cyclically Bending Coronary Artery Motions: Comparison Between 2-Link and 3-Link DESs.

    Iwasaki Kiyotaka, Kishigami Sho, Arai Jun, Ohba Takafumi, Zhu Xiaodong, Yamamoto Tadashi, Hikichi Yutaka, Umezu Mitsuo

    AMERICAN JOURNAL OF CARDIOLOGY   111 ( 7 ) 26B  2013.04  [Refereed]

    DOI

▼display all

Presentations

  • Finite element analysis of a cutting balloon and a scoring balloon on efficacy of fracturing calcification and risk of artery injury

    Xiaodong Zhu

    THE 9th WORLD CONGRESS OF BIOMECHANICS 

    Presentation date: 2022.07

    Event date:
    2022.07
     
     
  • Appropriate combination of physical model and computer simulation in medical device evaluation

    Kiyotaka. Iwasaki, Xiaodong. Zhu

    IUPESM WORLD CONGRESS 2022 

    Presentation date: 2022.06

  • none

    Xiaodong ZHU  [Invited]

    Presentation date: 2022.06

    Event date:
    2022.06
     
     
  • 腸骨静脈ステントの圧縮負荷に対する長期的耐久性を評価する加速耐久試験装置の開発に関する研究

    中村亮太, 村上慶輔, 北場紀香, 陸洪澤, 朱暁冬, 岩崎清隆

    第45回日本バイオレオロジー学会年会 

    Presentation date: 2022.06

    Event date:
    2022.06
     
     
  • Left main bifurcation morphology based on CT

    N. Kitaba, T. Okamura, H. Lu, X. Zhu, Y. Ishizuna, T. Fujimura, K. Iwasaki

    Euro PCR 2022 

    Presentation date: 2022.05

  • Development of a beating left main bifurcation model

    H. Lu, T. Okamura, N. Kitaba, X. Zhu, Y. Isizuna, T. Fujimura, K. Iwasaki

    Euro PCR 2022 

    Presentation date: 2022.05

  • 冠動脈分岐部病変におけるステント血栓症発生機序の解明にむけた非臨床試験方法の開発

    清水美羽, 篠田航, 星野滉一, 増田迪次, 朱暁冬, 岩﨑清隆

    第44回日本バイオレオロジー学会年会 

    Presentation date: 2021.07

    Event date:
    2021.07
     
     
  • 半周性石灰化病変血管モデルのカッティングバルーンによる拡張に関する有限要素解析

    朱暁冬, 岩﨑清隆

    第44回日本バイオレオロジー学会年会 

    Presentation date: 2021.07

  • Investigation of fracturing capability devices against calcification by a model

    K. Murakami, Y. Ishizuna, R. Ito, X. Zhu, K. Iwasaki

    EURO PCR 2021 

    Presentation date: 2021.05

  • Influence of Stent Design on Expansion of Calcified Lesions afterFracturing Calcification Using Lesion Preparation Devices

    R. Ito, Y. Ishizuna, X. Zhu, Z. Chen, K. Iwasaki

    EMBC2020 

    Presentation date: 2020.07

  • 左冠動脈主幹部分岐病変におけるステントのデザインとサイズが圧縮性に及ぼす影響の実験的検討

    松原海斗, 挽地裕, 杉山航太, 伊藤遼太, 朱暁冬, 坪子侑佑, 松橋祐輝, 梅津光生, 岩﨑清隆

    日本機械学会第32回バイオエンジニアリング講演会 

    Presentation date: 2019.12

  • Experimental Investigation of the Influence of Stent Design on Jailed Struts and Stent Malapposition Using a Left Main Coronary Artery Model

    K.Matsubara, Y. Hikichi, K. Sugiyama, R. Ito, X. Zhu, Y. Tsuboko, Y. Matsuhashi, M. Umezu, K. Iwasaki

    ICBME2019 

    Presentation date: 2019.12

  • Development of Calcification Models for Investigating Fracturing Performances of Coronary Lesion Modification Devices

    R. Ito, X. Zhu, K. Matsubara, K. Sugiyama, Z. Chen, Y. Ishizuna, M. Umezu, K. Iwasaki

    ICBME2019 

    Presentation date: 2019.12

  • 先進的医療機器の効率的開発を促進する患者を模した非臨床試験系の開発

    岩﨑清隆, 松橋祐輝, 坪子侑佑, 朱暁冬, 高田淳平, 笠貫宏, 梅津光生

    第58回日本生体医工学会大会 

    Presentation date: 2019.06

  • 腸骨静脈ステントの性能評価のためのブタ腹部大静脈の力学的特性の取得と加速耐久試験装置の開発

    湯本幹基, 杉山航太, 松原海人, 伊藤遼太, 朱暁冬, 梅津光生, 岩﨑清隆

    第42回日本バイオレオロジー学会年会 

    Presentation date: 2019.06

  • Influences of thickness and circumferential angles of calcification on the capability of fracturing calcification of the cutting balloon: an experimental investigation

    R. Ito, X. Zhu, K. Matsubara, K. Sugiyama, M. Yumoto, M. Umezu, K. Iwasaki

    Euro PCR 2019 

    Presentation date: 2019.05

  • Experimental investigation of influence of stent designs on jailed struts and flow using a left main coronary artery model

    K. Matsubara, Y. Hikichi, K. Sugiyama, X. Zhu, Y. Tsuboko, Y. Matsuhashi, R. Ito, K. Iwasaki

    Euro PCR 2019 

    Presentation date: 2019.05

  • 実臨床を模した先進的非臨床試験法の開発と活用

    岩﨑清隆, 山崎健二, 加瀬川均, 松橋祐輝, 高田淳平, 朱暁冬, 梅津光生

    第56回日本人工臓器学会大会 

    Presentation date: 2018.11

  • 浅大腿動脈でのねじり伸縮複合負荷環境における重複留置したステントの破断耐久性に関する研究

    水谷泰之, 松原海斗, 杉山航太, 湯本幹基, 伊藤遼太, 朱暁冬, 梅津光生, 岩﨑清隆

    日本機械学会第29回バイオフロンティア講演会 

    Presentation date: 2018.10

  • 生体吸収性スキャフォールドのデザインと破断耐久性に関する研究

    水谷泰之, 和泉恒平, 杉山航太, 松原海斗, 伊藤遼太, 湯本幹基, 朱暁冬, 梅津光生, 岩﨑清隆

    LIFE 2018(第34回ライフサポート学会 第18回日本生活支援工学会大会 日本機械学会 福祉工学シンポジウム2018) 

    Presentation date: 2018.09

  • 左冠動脈主幹部分岐病変におけるステントのコネクターとデザインが流れに及ぼす影響

    松原海斗, 水谷泰之, 朱暁冬, 杉山航太, 挽地裕, 梅津光生, 岩﨑清隆

    LIFE 2018(第34回ライフサポート学会 第18回日本生活支援工学会大会 日本機械学会 福祉工学シンポジウム2018) 

    Presentation date: 2018.09

  • Finite element analysis of potential migration of a stent graft into thoracic aotic aneurysm

    J. Kozaki, X. Zhu, K. Shukuzawa, M. Umezu

    EMBC 2018 

    Presentation date: 2018.07

  • Finite element analysis on expansion of cutting balloon in calcified coronary artery in comparison with conventional balloon

    X. Zhu, M. Umezu, K. Iwasaki

    EMBC 2018 

    Presentation date: 2018.07

  • 先進的非臨床試験法開発と国際標準化,グローバル展開

    岩﨑清隆, 松橋祐輝, 坪子侑佑, 朱暁冬, 笠貫宏, 梅津光生

    第57回日本生体医工学会大会 

    Presentation date: 2018.06

  • Micro-CT analysis of DK crush stenting vs. culotte stenting for left main distal bifurcation lesions: using three dimensional left main elastic bifurcated coronary artery models

    Y. Hikichi, G. Hongo, T. Kaneko, Y. Inoue, M. Natsuaki, Y. Mizutani, K. Matsubara, X. Zhu, K. Sugiyama, K. Node, K. Iwasaki

    EURO PCR 2018 The World-Leading Course in Interventional Cardiovascular Medicine 

    Presentation date: 2018.05

  • Finite element amalysis of the radial artery compression devices to investigate relationships between an inflation volume and compression pressure of wrist tissue

    X. Zhu, Y. Mizutani, M. Umezu, K. Iwasaki

    CMBBE 2018 

    Presentation date: 2018.03

  • Finite element analysis on the influence of distance between anterior and posterior papillary muscles on the stress distribution of the stentless mitral valve at closure

    J. Takada, X. Zhu, K. Mahara, H. Kasegawa, M.Umezu, K. Iwasaki

    CMBBE 2018 

    Presentation date: 2018.03

  • 生体吸収性スキャフォールドの経時的拡張保持特性と分解特性に関する研究

    水谷泰之, 和泉恒平, 高橋啓明, 松原海斗, 杉山航太, 朱暁冬, 梅津光生, 岩﨑清隆

    日本機械学会第30回バイオエンジニアリング講演会 

    Presentation date: 2017.12

  • 粒子イメージ流速計測法を用いたステントデザインが分岐狭窄病変における血流に及ぼす影響の検討

    水谷泰之, 松原海斗, 朱暁冬, 鮫島啓, 杉山航太, 挽地裕, 梅津光生, 岩﨑清隆

    日本機械学会第28回バイオフロンティア講演会 

    Presentation date: 2017.10

  • 有限要素法を用いた屈曲変形時における冠動脈ステントの応力解析

    朱暁冬, 梅津光生, 岩﨑清隆

    日本機械学会2017年度年次大会 

    Presentation date: 2017.09

  • Normo弁の性能試験:拍動流性能と応力解析

    高田淳平, 加瀬川均, 馬原啓太郎, 朱暁冬, 熊澤亮, 梅津光生, 岩﨑清隆

    第6回ステントレス僧帽弁臨床研究学術集会 

    Presentation date: 2017.09

  • Finite Element Analysis of Self-Expanding Nitinol Stent under Torsion and Shortening Conditions of superficial femoral Artery

    X. Zhu, M. Umezu, K Iwasaki

    39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 

    Presentation date: 2017.07

  • 浅大腿動脈のねじり短縮複合負荷に対する自己拡張型Ni-Ti合金製ステントの有限要素解析

    朱暁冬, 橋本雅也, 梅津光生, 岩﨑清隆

    第40回日本バイオレオロジー学会年会 

    Presentation date: 2017.05

  • Investigation of an optimal deployment method of polymer BRS to gain acute expansion using a stenotic mechanically-equivalent coronary artery model

    Y. Mizutani, K. Izumi, X. Zhu, M. Umezu, K. Iwasaki

    EURO PCR 2017 The World-Leading Course in Interventional Cardiovascular Medicine 

    Presentation date: 2017.05

  • 乳頭筋位置が腱索機能を有するステントレス僧帽弁の応力分布に及ぼす影響に関する有限要素解析

    高田淳平, 朱暁冬, 臼井一晃, 馬原啓太郎, 加瀬川均, 梅津光生

    日本機械学会第29回バイオエンジニアリング講演会 

    Presentation date: 2017.01

  • 有限要素法を用いた前後乳頭筋間距離がNormo弁の応力分布に与える影響の評価

    高田淳平, 朱暁冬, 臼井一晃, 加瀬川均, 岩崎清隆, 梅津光生

    非線形解析フォーラム2016 

    Presentation date: 2016.11

  • 冠動脈屈曲変形時にステントに生じる応力解析方法の構築:疲労破断予測に向けて

    朱暁冬, 岩崎清隆, 梅津光生

    非線形解析フォーラム2016 

    Presentation date: 2016.11

  • ヒト左心室モデルを有する拍動循環シミュレータを用いたNormo弁の拍動動態に関する研究

    岩﨑清隆, 加瀬川均, 臼井一晃, 高田淳平, 朱暁冬, 梅津光生

    第5回ステントレス僧帽弁臨床研究会学術集会 

    Presentation date: 2016.09

  • 複合負荷の作用する大腿膝窩動脈へ留置した自己拡張型Ni-Ti合金製ステントの疲労解析

    徳武祐諭, 岩﨑清隆, 朱暁冬, 梅津光生

    日本機械学会第28回バイオエンジニアリング講演会 

    Presentation date: 2016.01

  • 狭窄を有する下肢浅大腿動脈に事項拡張型ステントを適用時に生じる応力解析

    徳武祐論, 岩﨑清隆, 朱暁冬, 梅津光生

    第31回ライフサポート学会 

    Presentation date: 2015.09

  • 有限要素法を用いた繰り返し屈曲変形が冠動脈ステントの破断に及ぼす影響の検討

    朱暁冬, 岩﨑清隆, 徳武祐論, 梅津光生

    日本機械学会第25回バイオフロンティア講演会 

    Presentation date: 2014.10

  • 自己拡張型Ni-Ti合金製ステントを留置した浅大腿動脈の応力解析

    徳武祐論, 岩﨑清隆, 朱暁冬, 梅津光生

    日本機械学会第25回バイオフロンティア講演会 

    Presentation date: 2014.10

  • 繰り返し屈曲変形の角度変化量が冠動脈ステントの破断に及ぼす影響の有限要素法解析

    朱暁冬, 岩﨑清隆, 徳武祐論, 梅津光生

    LIFE2014 生活生命支援医療福祉工学系学会連合大会 

    Presentation date: 2014.09

  • 冠動脈屈曲病変変形を模擬した屈曲負荷環境における冠動脈ステントの応力解析方法の構築

    朱暁冬, 岩﨑清隆, 新井淳, 大場貴文, 徳武祐論, 梅津光生

    第53回日本生体医工学大会 

    Presentation date: 2014.06

  • 屈曲負荷型加速耐久試験装置による屈曲角度変化量が冠動脈ステントの破損耐久性に及ぼす影響の検討

    新井淳, 岩﨑清隆, 朱暁冬, 大場貴文, 徳武祐論, 山本匡, 挽地裕, 梅津光生

    日本機械学会第26回バイオエンジニアリング講演会 

    Presentation date: 2014.01

  • 下肢血管ステントの破損耐久性評価のための屈曲負荷型耐久試験装置の開発

    新井淳, 岩﨑清隆, 朱暁冬, 大場貴文, 徳武祐論, 山本匡, 挽地裕, 梅津光生

    日本機械学会第24回バイオフロンティア講演会 

    Presentation date: 2013.11

▼display all

Research Projects

  • Computational investigation on the efficacy and safety of the lesion preparation devices in calcified coronary artery with a cracking model of calcification

    日本学術振興会  科学研究費助成事業 基盤研究(C)

    Project Year :

    2022.04
    -
    2025.03
     

    朱 暁冬, 岩崎 清隆

  • ブレード付バルーンを用いた高度石灰化病変の拡張性能評価に関する研究

    早稲田大学  特定課題研究助成費

    Project Year :

    2018.04
    -
    2019.03
     

    朱 暁冬

Misc

  • Dk-Crush Stenting Increases the Risk of Incomplete Stent Apposition Compared With Culotte Stenting for the Treatment of Left Main Coronary Bifurcation Lesion: Analysis From Micro CT

    Yutaka Hikichi, Kaito Matsubara, Kouta Sugiyama, Xiaodong Zhu, Yusuke Tsuboko, Yuki Matsuhashi, Yohei Inoue, Masahiro Natsuaki, Koichi Node, Kiyotaka Iwasaki

    CIRCULATION   140  2019.11

    Research paper, summary (international conference)  

     View Summary

    0

  • The Requirements for Successful Left Main Stenting from the Results of the Bench Study

    挽地裕, MATSUBARA Kaito, SUGIYAMA Kouta, ZHU Xiaodong, TSUBOKO Yusuke, MATSUHASHI Yuki, YATSUNAMI Yuki, CHEN Wennhan, SAWAMI Kosuke, KAMISHITA Kohei, KANEKO Tetsuya, HONGO Hiroshi, INOUE Yohei, KAJIWARA Masataka, UCHINO Masumi, YAJIMA Ayumu, TAGO Motoko, SAKAMOTO Yoshiko, NATSUAKI Masahiro, NODE Koichi, IWASAKI Kiyotaka

    日本循環器学会学術集会(Web)   83rd  2019

    J-GLOBAL

  • Experimental investigation of influence of stent designs and sizes on stent apposition using a left main coronary artery bifurcation model

    松原海斗, 挽地裕, 杉山航太, 伊藤遼太, ZHU Xiaodong, 坪子侑佑, 松橋祐輝, 梅津光生, 岩崎清隆

    バイオエンジニアリング講演会講演論文集(CD-ROM)   32nd  2019

    J-GLOBAL

  • [title in Japanese]

    Iwasaki Kiyotaka

    Transactions of Japanese Society for Medical and Biological Engineering   56 ( 0 ) S11 - S11  2018

     View Summary

    <p>Developing advanced medical devices and treatments within affordable costs and expediting patients' access to such medical therapies are expected in worldwide.</p><p> In the development of medical devices, identification, evaluation, and reduction of individual risks are indispensable in parallel with evaluation of probable benefits. Effects of patent characteristics and doctor's skill should be considered to maximize device performances and reduce risks. Clinical trials for market approval of innovative and first-in-human medical devices are limited in inclusion criteria, number of patient enrollment, and monitoring period. Thus, we have been challenging to develop innovative patient-oriented testing methodologies to accelerate medical device development, to evaluate safety and probable efficacy of medical devices, and to support scientific-based approval decision, which, we believe, will contribute to the acceleration of patients' access to new technologies. We are also engaged in developing guidance and standards to evaluate innovative medical devices and driving those global expansions.</p>

    DOI CiNii

  • 2B15 Fatigue analysis on a self-expandable Nitinol stent deployed in femoral-popliteal artery under a multiple-load environment

    TOKUTAKE Hirotsugu, IWASAKI Kiyotaka, ZHU Xiaodong, UMEZU Mitsuo

      2016 ( 28 ) "2B15 - 1"-"2B15-3"  2016.01

     View Summary

    The purpose of this study is to investigate influences of multi-loads and stenosis in femoral-popliteal artery on fracture of self-expandable stent using finite element analysis. A nitinol alloy stent was selected. The three-dimensional CAD models of the stent and vessel were constructed using SolidWorks. First, the stent was compressed by four cylinder models. Second, the stent was deployed in 50%, 60% and 75% stenotic artery models. Third, cyclic multi-loads were applied to the artery model. Multi-loads were two types. One is shortening of 12.7% and torsion of 0.28 degree/mm (Average). Another is shortening of 6.9% and torsion of 0.14 degree/mm (Half of average). When average loads were applied, strain amplitude of stent were 0.61%, 0.75%, and 0.87% in 50%, 60% and 75% stenotic model. When half of average loads were applied, those were 0.36%, 0.41%, and 0.54%. According to constant-life diagrams of average loads, when the stent was deployed in over 60% stenotic artery model, risk of fracture was high. This study indicated that risk of fracture is increased by multi-loads and stenosis.

    CiNii

  • B207 Strain analysis on a self-expandable Nitinol stent deployed in superficial femoral artery

    TOKUTAKE Hirotsugu, IWASAKI Kiyotaka, ZHU Xiaodong, UMEZU Mitsuo

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering   2015 ( 26 ) 113 - 114  2015.10

    CiNii

  • C110 Stress analysis on superficial femoral artery deployed with a self-expandable Nitinol stent

    TOKUTAKE Hirotsugu, IWASAKI Kiyotaka, ZHU Xiaodong, UMEZU Mitsuo

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering   2014 ( 25 ) 77 - 78  2014.10

    CiNii

  • C109 Finite element analysis on the influence of cyclic bend angles on coronary stent fracture

    ZHU Xiaodong, IWASAKI Kiyotaka, TOKUTAKE Hirotsugu, UMEZU Mitsuo

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering   2014 ( 25 ) 75 - 76  2014.10

    CiNii

  • Construction on finite element analysis method of coronary stent in cyclical bending-load environment simulated bending motion of coronary artery

    Xiaodong Zhu, Kiyotaka Iwasaki, Jun Arai, Takafumi Oba, Hirotugu Tokutake, Mitsuo Umezu

    Transactions of Japanese Society for Medical and Biological Engineering   52   106 - O-107  2014.08

    Rapid communication, short report, research note, etc. (scientific journal)  

     View Summary

    [Aim] We aimed to construct a method of finite element analysis (FEA) on a coronary stent deployed in cyclically-bended artery. [Method] A CoCr alloy stent was analyzed using ADINA8.9 in three steps: (1) crimp the stent onto a balloon, (2) deploy the stent in the artery model by balloon inflation, (3) bend the artery model in the angle range from 105° to 125°. Finally, the fatigue safety factor (FSF) was calculated by stress amplitude and mean stress.[Result and Discussion] We found that the 1/FSF is higher at the links and crowns connected to links at the bended region. The portion of stent fracture observed in the durability tests was coincident with the higher 1/FSF region. [Conclusion] We constructed the FEA method of the coronary stent in the successive processes of crimping onto the balloon, deploying and bending in the artery model.

    DOI

  • 2D32 Experimental analysis on influence of angular amplitude on fracture resistance of the coronary stents using an accelerated bend-load durability tester

    ARAI Jun, IWASAKI Kiyotaka, ZHU Xiaodong, OBA Takafumi, TOKUTAKE Hirotsugu, YAMAMOTO Tadashi, HIKICHI Yutaka, UMEZU Mitsuo

      2014 ( 26 ) 413 - 414  2014.01

    CiNii

  • A213 Development of a bend-load durability tester for evaluating fracture resistance of endovascular stents

    Arai Jun, IWASAKI Kiyotaka, ZHU Xiaodong, OBA Takafumi, TOKUTAKE Hirotsugu, YAMAMOTO Tadashi, HIKICHI Yutaka, UMEZU Mitsuo

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering   2013 ( 24 ) 73 - 74  2013.10

    CiNii

▼display all

 

Teaching Experience

  • 理工学基礎実験1B

    早稲田大学  

    2018.09
    -
    2019.09
     

  • 理工学基礎実験2A

    早稲田大学  

    2017.10
    -
    2019.03
     

 

Internal Special Research Projects

  • ブレード付バルーンを用いた高度石灰化病変の拡張性能評価に関する研究

    2018  

     View Summary

    We aimed to investigate the influence on the expansion of cutting balloon with different sizes in coronary artery with calcified plaque by finite element analysis.The finite element models of blade, pad, balloon, calcified plaque (arc 180deg) and artery were generated. First, the balloon model was crimped and compressed to obtain the folded shape and then three sets of blade models and pad models were constrained to the surface of the balloon model. Next, the whole cutting balloon model was assembled in the calcified artery model and pressure was applied to the inner surface of the balloon model. Different sizes of balloon diameter with two types of blade direction (type1: one blade inside plaque and type 2: two blades inside plaque) were considered and simulated.&nbsp;The maximum stresses in the plaque models in type2 were greater than those in type 1. However, in contrast the maximum principal tensile stresses occurred in artery models in type1 were larger than those in type 2. These results indicated that type 2 is more effective and safer than type1 associated with the blade direction during cutting balloon inflation. It showed that the risk of dissection is high between the plaque and artery wall.