Updated on 2022/05/25

写真a

 
TSUBOKO, Yusuke
 
Affiliation
Faculty of Science and Engineering, Waseda Research Institute for Science and Engineering
Job title
Junior Researcher(Assistant Professor)
Mail Address
メールアドレス
Profile
Dr. Yusuke Tsuboko earned the Ph.D. degrees in Biomedical Engineering from Tohoku University, Sendai, Japan in 2016. From 2014 to 2016, he worked at the Department of Medical Engineering and Cardiology, PreClinical Research Center, Institute of Developing, Aging and Cancer, Tohoku University as a Research Fellow of Japan Society for the Promotion of Science. From 2017 to 2018, he worked as a Research Associate at the Institute for Medical Regulatory Science, Organization for University Research Initiatives, Waseda University, Tokyo, Japan. He is currently working as an Assistant Professor at the Waseda Research Institute for Science and Engineering, Waseda University.
Dr. Tsuboko has been involved in numerous preclinical testing of implantable cardiovascular medical devices, particularly related to heart valve prostheses and ventricular assist devices. His main research interests are Regulatory Science for Medical Devices, Cardiovascular Engineering, Artificial Internal Organs, and Circulatory Simulations. His research aims to contribute the providing earlier access to innovative medical devices for patients by using engineering-based preclinical evaluation methodology.

Concurrent Post

  • Faculty of Science and Engineering   School of Creative Science and Engineering

Education

  • 2013.04
    -
    2016.03

    Tohoku University   Graduate School of Biomedical Engineering   Doctoral Course  

  • 2011.04
    -
    2013.03

    Tohoku University   Graduate School of Biomedical Engineering   Master's Course  

  • 2007.04
    -
    2011.03

    Yamagata University   Faculty of Engineering   Department of Bio-system Engineering  

Degree

  • 2016.03   Tohoku University   Ph.D. in Biomedical Engineering

Research Experience

  • 2019.04
    -
    Now

    Waseda University   Waseda Research Institute for Science and Engineering   Junior Researcher (Assistant Professor)

  • 2020.04
    -
    Now

    Waseda University   Institute for Medical Regulatory Science, Comprehensive Research Organization   Member

  • 2020.04
    -
    Now

    Waseda University   School of Creative Science and Engineering   Lecturer (Concurrent post)

  • 2018.04
    -
    Now

    National Institute of Health Sciences   Division of Medical Devices   Collaborative Researcher

  • 2021.04
    -
    2022.03

    Tohoku University   Institute of Fluid Science   Collaborative Researcher

  • 2020.05
    -
    2022.03

    Tokyo University of Agriculture and Technology   Faculty/Graduate School of Engineering   Adjunct Lecturer

  • 2019.04
    -
    2020.03

    Waseda University   Institute for Medical Regulatory Science, Organization for University Research Initiatives   Member

  • 2018.04
    -
    2019.03

    Tohoku University   PreClinical Research Center, Institute of Development, Aging and Cancer   Collaborative Researcher

  • 2017.06
    -
    2019.03

    Waseda University   Institute for Medical Regulatory Science   Research Associate

  • 2017.04
    -
    2017.05

    Waseda University   Institute for Medical Regulatory Science   Adjunct Researcher

  • 2016.04
    -
    2017.03

    Japan Society for the Promotion of Science   JSPS Postdoctoral Research Fellow

  • 2015.04
    -
    2016.03

    Japan Society for the Promotion of Science   JSPS Research Fellow (DC2)

  • 2014.04
    -
    2015.03

    Sendai College of Medical Health and Sports   Department of Orthoptics   Adjunct Lecturer

  • 2013.04
    -
    2014.11

    Institute of Development, Aging and Cancer, Tohoku University   Department of Medical Engineering and Cardiology   Research Assistant

  • 2013.12
    -
    2014.03

    Industrial Technology Institute, Miyagi Prefectural Government   Material Development and Analysis Technology Department   Intern

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Professional Memberships

  • 2019.08
    -
    Now

    THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

  • 2017.07
    -
    Now

    Society for Regulatory Science of Medical Products

  •  
     
     

    JAPANESE ASSOCIATION OF CARDIOVASCULAR INTERVENTION AND THERAPEUTICS

  •  
     
     

    THE VISUALIZATION SOCIETY OF JAPAN

  •  
     
     

    THE INSTITUTE OF ELECTRICAL AND ELECTRONIC ENGINEERS

  •  
     
     

    JAPANESE SOCIETY OF VETERINARY CARDIOLOGY

  •  
     
     

    JAPANESE SOCIETY FOR MEDICAL AND BIOLOGICAL ENGINEERING

  •  
     
     

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

  •  
     
     

    Japanese Society of Biorheology

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Research Areas

  • Medical technology assessment

  • Biomaterials   Artificial Organs

  • Biomedical engineering   Artificial Organs

Research Interests

  • 心臓血管外科学

  • Regulatory Science for Medical Devices

  • Preclinical Evaluation

  • Artificial Heart

  • Artificial Organs

  • Biomedical Engineering

  • Cardiovascular Engineering

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Papers

  • Latest outcomes of transcatheter left atrial appendage closure devices and direct oral anticoagulant therapy in patients with atrial fibrillation over the past 5 years: a systematic review and meta-analysis.

    Keiichi Takeda, Yusuke Tsuboko, Kiyotaka Iwasaki

    Cardiovascular intervention and therapeutics    2022.01  [Refereed]  [Domestic journal]

     View Summary

    Left atrial appendage closure (LAAC) are emerging treatment for patients with atrial fibrillation (AF). However, data on the safety, efficacy, and medications for LAAC devices in patients with AF are lacking. We aimed to investigate the incidence of all-cause mortality, stroke, and major bleeding in AF patients with LAAC devices and DOACs. Moreover, we aimed to investigate the incidence rate of device-related thrombus (DRT) and the medications used in the management of AF patients with LAAC devices to gain insights into achieving better outcome. Based on a literature search using PubMed, EMBASE, Cochrane Library, and Web of Science databases between January 2015 and December 2020, eight LAAC device studies that used WATCHMAN and Amulet, and three DOAC studies that used rivaroxaban, with a total of 24,055 AF patients (LAAC devices, n = 2855; DOAC, n = 21,200), were included. A random-effects model was used to incorporate heterogeneity among studies. The pooled incidence of events per person-years were as follows: all-cause mortality, 0.06 (95% confidence interval [CI] 0.02-0.10) for WATCHMAN, 0.04 (95% CI 0.00-0.14) for Amulet, and 0.03 (95% CI 0.01-0.04) for rivaroxaban; stroke; 0.02 (95% CI 0.00-0.04) for WATCHMAN, 0 for Amulet, and 0.01 (95% CI 0.01-0.02) for rivaroxaban; major bleeding, 0.04 (95% CI 0.02-0.06) for WATCHMAN, 0.02 (95% CI 0.00-0.06) for Amulet, and 0.02 (95% CI 0.01-0.03) for rivaroxaban. The incidence rate of DRT was 2.3%, and complications were reported in 9%. The incidence of all-cause mortality, stroke, and major bleeding were similar between LAAC devices and DOACs. The rate of complications was acceptable, and those of DRT were lower than the average incidence reported in previous studies. However, further follow-up is needed. Concomitant anticoagulant and antiplatelet therapies should be further evaluated to find the optimal regimen for AF patients with LAAC devices.

    DOI PubMed

  • The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio.

    Masafumi Nakayama, Nobuhiro Tanaka, Takashi Uchiyama, Takaaki Ohkawauchi, Yusuke Tsuboko, Kiyotaka Iwasaki, Yoshiaki Kawase, Hitoshi Matsuo

    Scientific reports   11 ( 1 ) 13824 - 13824  2021.07  [Refereed]  [International journal]

     View Summary

    Assessment of coronary artery lesions using the fractional flow reserve and instantaneous flow reserve (iFR) measurements has been found to reduce the incidence of further cardiovascular events. Here, we investigated differences in terms of coronary flow velocity and resistance within the analysis interval between the iFR and the intracoronary electrocardiogram (IC-ECG)-triggered distal/aortic pressure (Pd/Pa) ratio (ICE-T). We enrolled 23 consecutive patients (n = 33 stenoses) who required coronary flow measurements. ICE-T was defined as the average Pd/Pa ratio in the period corresponding to the isoelectric line of the IC-ECG. We compared the index value, flow velocity, and intracoronary resistance during the analysis intervals of the iFR and the ICE-T, both at rest and under hyperemia. ICE-T values and ICE-T intracoronary resistance were both found to be significantly lower, whereas flow velocity was significantly higher than those of the iFR at both rest and under hyperemia (P < 0.001), and all fluctuations in ICE-T values were also significantly smaller than those in the iFR. In conclusion, the ICE-T appears theoretically superior to pressure-dependent indices for analyzing phases with low and stable resistance, without an increase in invasiveness.

    DOI PubMed

  • Reflected wave intensity increases based on aortic diameter after endovascular aortic therapy in a goat model.

    Tomohiro Takano, Masumi Iwai-Takano, Yusuke Tsuboko, Yasuyuki Shiraishi, Tomoyuki Yambe, Takashi Igarashi, Hitoshi Yokoyama

    Scientific reports   11 ( 1 ) 3830 - 3830  2021.02  [Refereed]  [International journal]

     View Summary

    Reflected wave increases after endovascular aortic repair (EVAR) in patients with aortic aneurysm. This affects the left ventricular (LV) diastolic function and leads to a poor prognosis. This study aimed to evaluate the relationship between increased reflected wave amplitude and aortic diameter after EVAR. EVAR was performed in seven healthy goats. We assessed wave intensity (WI), aortic diameter, and stiffness parameter β. Moreover, we evaluated the relationship between negative reflected wave (NW, reflected waves toward the heart from the periphery by WI) and other parameters after EVAR. Results showed an increase in stiffness parameter β (3.5 ± 0.3 vs 15.9 ± 4.7, p = 0.018) and a decrease in the change of aortic diameter (6.9 ± 0.7 vs 2.7 ± 0.4%, p = 0.018) after EVAR. The NW was significantly amplified after EVAR from baseline (-589.8 ± 143.4 to  - 1192.3 ± 303.7 mmHg-m/sec3, p = 0.043). The NW showed a significant correlation with maximum aortic diameter (R = 0.707, p = 0.038) and minimum aortic diameter (R = 0.724, p = 0.033). The reflected wave was enhanced after EVAR and was correlated to the aortic diameter at the stent-graft site. It is important to consider that patients with smaller aortic diameters in landing zone who undergo EVAR may develop LV dysfunction.

    DOI PubMed

  • Dk-Crush Stenting Increases the Risk of Incomplete Stent Apposition Compared With Culotte Stenting for the Treatment of Left Main Coronary Bifurcation Lesion: Analysis From Micro CT

    Yutaka Hikichi, Kaito Matsubara, Kouta Sugiyama, Xiaodong Zhu, Yusuke Tsuboko, Yuki Matsuhashi, Yohei Inoue, Masahiro Natsuaki, Koichi Node, Kiyotaka Iwasaki

    CIRCULATION   140  2019.11  [Refereed]

     View Summary

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  • Sophisticated Hydrodynamic Simulation of Pulmonary Circulation for the Preclinical Examination of Right Heart Circulatory Assist Device

    Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Kiyotaka Iwasaki, Mitsuo Umezu, Tomoyuki Yambe

    IFMBE Proceedings   68 ( 3 ) 717 - 720  2018.05  [Refereed]

    Authorship:Lead author, Corresponding author

    DOI

  • 生体内組織の局所温度制御による新しい血圧コントロールの医工学的基礎検討

    弓場充, 中潟寛, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 平恭紀, 山家智之

    東北醫學雑誌   129 ( 1 ) 108  2017  [Refereed]

  • 食感特性評価のための嚥下挙動解析

    平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 山家智之

    東北醫學雑誌   129 ( 1 ) 109  2017  [Refereed]

  • Engineering based assessment for a shape design of a pediatric ePTFE pulmonary conduit valve

    Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Tomoyuki Yambe, Hidekazu Miura, Seitaro Mura, Masaaki Yamagishi

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS   2016-October   4313 - 4316  2016.10  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    © 2016 IEEE. The authors examined the hemodynamic characteristics of expanded polytetrafluoroethylene (ePTFE) pulmonary valved conduits quantitatively by our originally developed pediatric pulmonary mechanical circulatory system, in order to suggest the optimal shape design. The system consisted of pneumatically driven right atrium and ventricle model, a pulmonary valve chamber, and elastic pulmonary compliance model with peripheral vascular resistance units, a venous reservoir. We employed two different types of ePTFE valve and evaluated the relationship between the leaflets motion and hemodynamic characteristics by using a high-speed video camera. As a result, we successfully reproduced hemodynamic simulations in our pediatric pulmonary mock system. We confirmed that the presence of bulging sinuses in the pulmonary valved conduit reduced the transvalvular energy loss and increased the valve opening area during systolic period. Our engineering-based in vitro analysis could be useful for proposing a shape design optimization of sophisticated pediatric ePTFE pulmonary valve.

    DOI PubMed

  • Establishment of the evaluation method for the right ventricular outflow tract reconstruction

    Yusuke TSUBOKO

    Tohoku University    2016.03  [Refereed]

    Authorship:Lead author

  • Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats

    Takuya Shiga, Yasuyuki Shiraishi, Kyosuke Sano, Yasunori Taira, Yusuke Tsuboko, Akihiro Yamada, Hidekazu Miura, Shintaro Katahira, Masatoshi Akiyama, Yoshikatsu Saiki, Tomoyuki Yambe

    Journal of Artificial Organs   19 ( 1 ) 8 - 13  2016.03  [Refereed]  [Domestic journal]

     View Summary

    © 2015, The Japanese Society for Artificial Organs. Implantation of a total artificial heart (TAH) is one of the therapeutic options for the treatment of patients with end-stage biventricular heart failure. There is no report on the hemodynamics of the functional centrifugal-flow TAH with functional atrial contraction (fCFTAH). We evaluated the effects of pulsatile flow by atrial contraction in acute animal models. The goats received fCFTAH that we created from two centrifugal-flow ventricular assist devices. Some hemodynamic parameters maintained acceptable levels: heart rate 115.5 ± 26.3 bpm, aortic pressure 83.5 ± 10.1 mmHg, left atrial pressure 18.0 ± 5.9 mmHg, pulmonary pressure 28.5 ± 9.7 mmHg, right atrial pressure 13.6 ± 5.2 mmHg, pump flow 4.0 ± 1.1 L/min (left) 3.9 ± 1.1 L/min (right), and cardiac index 2.13 ± 0.14 L/min/m2. fCFTAH with atrial contraction was able to maintain the TAH circulation by forming a pulsatile flow in acute animal experiments. Taking the left and right flow rate balance using the low internal pressure loss of the VAD pumps may be easier than by other pumps having considerable internal pressure loss. We showed that the remnant atrial contraction effected the flow rate change of the centrifugal pump, and the atrial contraction waves reflected the heart rate. These results indicate that remnant atria had the possibility to preserve autonomic function in fCFTAH. We may control fCFTAH by reflecting the autonomic function, which is estimated with the flow rate change of the centrifugal pump.

    DOI PubMed

  • 食感特性評価のための嚥下挙動解析

    平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 駒村寛, 東條誠也, 八亀健, 山重大樹, 山家智之

    第20回日本統合医療学会学術大会論文集   20 ( 1 ) 38-42  2016  [Refereed]

  • 脈波診断に医工学的根拠を付与する定量的評価手法の開発

    山田昭博, 坪子侑佑, 井上雄介, 平恭紀, 白石泰之, 関隆志, 山家智之

    第20回日本統合医療学会学術大会論文集   20 ( 1 ) 32-37  2016  [Refereed]

  • 非臨床試験および前臨床試験手法を用いた心臓血管系診断に対する科学的アプローチ

    井上雄介, 白石泰之, 山田昭博, 坪子侑佑, 平恭紀, 池田純平, 荒川友哉, 弓場充, 阿部裕輔, 山家智之

    第20回日本統合医療学会学術大会論文集   20 ( 1 ) 26-31  2016  [Refereed]

  • Effect of right atrial contraction on prosthetic valve function in a mechanical pulmonary circulatory system

    Yusuke Tsuboko, Yasuyuki Shiraishi, Satoshi Matsuo, Akihiro Yamada, Hidekazu Miura, Takuya Shiga, Mohamed Omran Hashem, Tomoyuki Yambe

    Journal of Biomechanical Science and Engineering   11 ( 3 ) 15 - 00356  2016  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    © 2016 The Japan Society of Mechanical Engineers. Improving the inflow characteristics of the right ventricular function and pulmonary circulatory hemodynamics was essential for more precise evaluation of newly designed heart valves. To examine a pulmonary hemodynamics, the authors have been developing a pulmonary mechanical mock circulatory system. In this study, the pneumatically driven right atrium model was newly developed for clarifying the effect of atrial contraction on the dynamic behavior of pulmonary prosthetic valves. We focused on the hemodynamic behavior of the outflow mechanical heart valve of the right ventricle that could be affected by the right atrial dynamic motion. A medical-grade bileaflet valve was employed and installed into the outflow portion of the right ventricle model and examined its changes in hemodynamic behavior caused by the active right atrial contraction. With the active atrial contraction, hemodynamic waveforms of either the right ventricle or atrium were obtained using the modified pulmonary mock circulatory system. The characteristics with atrial contraction were well simulated as the natural hemodynamics. The right ventricular output increased by around 5% and the peak regurgitant flow at the moment of valve closing significantly decreased by the presence of the atrial contraction. Our mechanical circulatory system could simulate the end-diastolic right ventricular inflow characteristics. We found that the atrial contraction under the low pressure condition such as pulmonary circulation promoted earlier valve closing and prolonged closing duration of prosthetic valve. The simulation of right atrial contraction was important in the quantitative examination of right heart prosthetic valves for congenital heart malformation.

    DOI CiNii J-GLOBAL

  • Effect of valsalva in the pulmonary prosthetic conduit valve on hemodynamic function in a mock circulatory system

    Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Tomoyuki Yambe, Satoshi Matsuo, Yoshikatsu Saiki, Masaaki Yamagishi

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS   2015-November   278 - 281  2015.11  [Refereed]  [International journal]

     View Summary

    © 2015 IEEE. Pulmonary conduit valves are used as one of the surgical treatment methods of congenital heart diseases. We have been designing a sophisticated pulmonary conduit valve for the right ventricular outflow tract reconstruction in pediatric patients. In this study, two types of polyester grafts with or without bulging structures for the conduit valves were used and evaluated from the hemodynamic point of view focusing on the application of these conduit valves in the grown-up congenital heart failure patients. We examined valvular function in the originally developed pulmonary mock circulatory system, which consisted of a pneumatic driven right ventricular model, a pulmonary valve chamber, and an elastic pulmonary compliance model with peripheral vascular resistance units. Prior to the measurement, a bileaflet valve was sutured in each conduit. Each conduit valve was installed in the mock right ventricular outflow portion, and its leaflet motion was obtained by using a high-speed camera synchronously with pressure and flow waveforms. As a result, we could obtain hemodynamic changes in two different types of conduits for pulmonary valves, and it was indicated that the presence of the Valsalva shape might be effective for promoting valvular response in the low cardiac output condition.

    DOI PubMed

  • Development of a thermodynamic control system for the Fontan circulation pulsation device using shape memory alloy fibers

    Akihiro Yamada, Yasuyuki Shiraishi, Hidekazu Miura, Hashem Mohamed Omran Hashem, Yusuke Tsuboko, Masaaki Yamagishi, Tomoyuki Yambe

    Journal of Artificial Organs   18 ( 3 ) 199 - 205  2015.09  [Refereed]  [Domestic journal]

     View Summary

    © 2015, The Japanese Society for Artificial Organs. The Fontan procedure is one of the common surgical treatments for circulatory reconstruction in pediatric patients with congenital heart disease. In Fontan circulation, low pulsatility may induce localized lung ischemia and may impair the development of pulmonary peripheral endothelial cells. To promote pulmonary circulation in Fontan circulation, we have been developing a pediatric pulmonary circulatory pulsation device using shape memory alloy fibers attached from the outside of total cavopulmonary connection. In this study, we developed a new thermal control system for the device and examined its functions. We mounted on the device 16 fibers connected in parallel around an ePTFE graft circumferentially. To provide optimized contraction, we designed the new thermal control system. The system consisted of a thermistor, a pressure sensor, and a regulator that was controlled by the adaptive thermodynamic transfer functions. We monitored the parameters and calculated heat transfer function as well as pressure distribution on the graft surface. Then we examined and compared the dynamic contractile pressure and changes in surface temperature. As a result, by the application of the control based on the new feedback system analysis, the circumferential contractile pressure increased by 35 %. The adaptive thermodynamic regulation was useful for the selection of alternative thresholds of the surface temperature of the graft. The system could achieve effective contraction for the pulsatile flow generation by the device.

    DOI PubMed

  • Preliminary Study on Mathematical Modeling for the Shape Design of Expanded Polytetrafluoroethylene Pulmonary Valved Conduit

    Tsuboko Yusuke, Shiraishi Yasuyuki, Suzuki Ichiro, Yamada Akihiro, Miura Hidekazu, Yamagishi Masaaki, Yambe Tomoyuki

    Advanced Biomedical Engineering   4   144 - 150  2015  [Refereed]

    Authorship:Lead author, Corresponding author

     View Summary

    Right ventricular outflow tract (RVOT) reconstruction surgery is one of the surgical strategies for congenital heart failure, and is commonly used for the treatment of severe heart failure with pulmonary valvular problems. An expanded polytetrafluoroethylene (ePTFE) pulmonary valve was invented for RVOT reconstruction, and the authors have tested its hemodynamic and hydrodynamic characteristics for design improvement. The special features of the ePTFE valve are as follows: (a) anatomically identical trileaflet structure, and (b) bulging sinuses in the vicinity of leaflets. In this study, we used three types of pulmonary valves; an ePTFE valve with bulging sinuses, an ePTFE valve in straight conduit, and a natural pulmonary arterial valve extracted from a goat after the animal experiment. Then we measured the hemodynamic characteristics of the various types of ePTFE valves using a mechanical pulmonary circulatory system. Next, using the pressure and flow data derived from the mechanical circulatory system, we calculated the mechanical design parameters of the ePTFE valves based on a numerical modeling method by inverse analyses. The mathematical parameters we used in the model were inertia, damping, and stiffness coefficients, and we compared these values among three types of pulmonary valves. We succeeded to estimate the mechanical parameters for each valve from the hemodynamic data. The results suggest that the ePTFE valve with bulging sinuses may exhibit similar parametric characteristics to those calculated from the natural pulmonary heart valves.

    DOI CiNii J-GLOBAL

  • Design diversity in artificial passive-active circulatory support systems

    Yasuyuki Shiraishi, Hidekazu Miura, Yusuke Tsuboko, Akihiro Yamada, Yoshikazu Kaneko, Hashem Mohamed Omran Hashem, Takuya Shiga, Shintaro Katahira, Masatoshi Akiyama, Yoshikatsu Saiki, Kiyozo Morita, Masaaki Yamagishi, Yi Qian, Tomoyuki Yambe, Dai Homma

    Transactions of Japanese Society for Medical and Biological Engineering   52   OS - 9  2014.08  [Refereed]

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. We have been developing several variations of circulatory assist systems based on nano or micro engineering technologies. One of the special features of the design of these new styles of circulatory assist devices will be a passive controllability according to the native physiological signal transmission and hemodynamic responses. In this study, we presented the design features and the research diversity for the development of passive-active circulatory support systems, such as artificial myocardial assist devices, circulatory valves, epi-cardial or vascular support systems for mechanical assistance in chronic or congenital heart failure patients. We employed a covalent type shape memory alloy fiber as the actuator for the implantable artificial internal organs for sophisticated ventricular or hemodynamic support devices.

    DOI

  • Examination of natural esophageal mechanical properties for the design of an artificial esophagus

    Yasunori Taira, Kurodo Kamiya, Yasuyuki Shiraishi, Hidekazu Miura, Mohamed Omran Hashem, Akihiro Yamada, Yusuke Tsuboko, Kyosuke Sano, Dai Homma, Tomoyuki Yammbe

    Transactions of Japanese Society for Medical and Biological Engineering   52   O - 557  2014.08  [Refereed]

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. In order to promote peristaltic function in the patients with the end stage of esophageal cancer, we have been developing an implantable artificial esophagus. Surgical treatments, such as gastroesophagostomy, are applied for alternative reconstruction in the patients, however, the peristaltic motion will be eliminated. In this study, we focused on the distributed function in the native esophagus and examined stress-strain characteristics from proximal to distal portion using freshly extracted goat’s esophagus. Prior to the measurement, we developed a new tension test apparatus. As a result, we could evaluate the circumferential esophageal characteristic variations. Then it was suggested that the circumferential stress analysis might be useful for more sophisticated design of artificial esophageal specifications, which would be consistent with the physiological demand as well as the passive structural effects.

    DOI

  • Analysis of cardiovascular and autonomic nerve response to visual stress for preclinical medicine

    Hidekazu Miura, Eiko Takasaki, Daiki Yamashige, Yasunori Taira, Akihiro Yamada, Yusuke Tsuboko, Kyosuke Sano, Yasuyuki Shiraishi, Tomoyuki Yambe

    Transactions of Japanese Society for Medical and Biological Engineering   52   SY - 25  2014.08  [Refereed]

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. Stress is an important factor when we consider responses in the cardiovascular and the autonomic nervous systems. After ethical committee allowance, responses in the cardiovascular system and autonomic nerve were evaluated with the individual characteristics. We investigated relationship between responses to the stress and individual characteristics. Healthy adult participants were assessed with type A scale, Beck depression scale, Hostility scale and Japanese Coronary-prone Behavior Scale (JCBS). Participants were showed hateful images and performed a mathematical task (Sudoku). Heart rate (HR), systolic blood pressure (SBP), LF/HF and pulse wave transmission time (PTT) were measured. The maximum value of the cross-correlation coefficients between BP and HR (ρ<inf>max</inf> BH), BP and PTT (ρ<inf>max</inf> BT) were analyzed. In both tasks, higher type A scored groups had larger LF/HF, suggesting that the individual characteristics were correlated with the autonomic nervous system. Significant correlation between the Beck depression score and the decrease in PTT and the increase in BP during hateful images were observed. High type A scored or high depression level had the relationship with the stress.

    DOI

  • Development of sensorless control system for pediatric pulmonary circulatory assist device using shape memory alloy fibers

    Akihiro Yamada, Yasuyuki Shiraishi, Mohamed Omran Hashem, Hidekazu Miura, Yusuke Tsuboko, Tomoyuki Yambe, Dai Homma, Masaaki Yamagishi

    Transactions of Japanese Society for Medical and Biological Engineering   52   O - 539  2014.08  [Refereed]

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. In order to promote the pulmonary circulation after Fontan operation, we developed a pediatric pulmonary circulatory assist device using shape memory alloy fibers. In this study, we developed the sensor-less control system for the pulmonary circulatory assist device and examined its fundamental functions. The SMA fiber showed a linear relationship between the internal resistance and longitudinal contraction. We measured the change in current of the fiber during the operation. Electric current increased from 1.4 to 1.8 A during operation, and the maximum current supply was measured at the end of the contraction. Therefore, we could be estimated the device contraction by the measurement of current which was calculated by voltage sampling of fiber units. Prevention of the overheating of the fiber unit was one of the problem throughout the operation of the device, and we could achieve the elimination of excess current supply by detecting the fiber voltage as well as the estimation of electric power supply without ineffective contraction. Consequently, the method in this study might be applied as a highly reliable totally implantable system.

    DOI

  • Measurement of the pulmonary input impedance for development of a sophisticated pulmonary vascular resistance model

    Yusuke Tsuboko, Yasuyuki Shiraishi, Akihiro Yamada, Takuya Shiga, Kyosuke Sano, Tomoyuki Yambe

    Transactions of Japanese Society for Medical and Biological Engineering   52   O - 315  2014.08  [Refereed]

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. The authors have been developing a pulmonary mechanical circulatory system in order to establish design parameters of artificial cardiovascular assist devices. In the quantitative examination of heart valves in pulmonary mock circulation, interactive changes in pressure and flow are regulated by pulmonary impedance characteristics. We focused on the native characteristics changes in impedance in the pulmonary circulation. To obtain the effect of respiratory control on pulmonary resistance, we measured pulmonary arterial pressure and flow in adult goat under the different respiratory settings with open- and closed-chest condition. We calculated pulmonary input impedance in two respiratory conditions under the anesthetized open-chest positive pressure ventilation (PPV) and the awake spontaneous respiration (SR). Longitudinal impedance in SR showed lower than in PPV. Characteristic impedance in SR was bigger than in PPV. Therefore, we concluded that the pulmonary impedance should be considered for more sophisticated simulation of pulmonary circulatory support devices.

    DOI

  • 小型化した遠心型補助人工心臓EVAHEARTの慢性動物実験の血液動態の評価

    三浦 英和, 山重, 大樹, 高崎, 映子, 白石, 泰之, 平, 恭紀, 坪子, 侑佑, 山田, 昭博, 山崎, 健二, 西中, 知博, 山田, 有希子, 片平, 晋太郎, 秋山, 正年, 齋木, 佳克, 山家 智之

    人工臓器   43 ( 2 ) S - 151  2014

    J-GLOBAL

  • 高速動画撮影による右心系模擬循環での人工弁の挙動解析

    坪子 侑佑, 松尾, 諭志, 白石, 泰之, 山田, 昭博, 三浦, 英和, 平, 恭紀, 佐野, 恭介, 武良, 盛太郎, 齋木, 佳克, 山家 智之

    人工臓器   43 ( 2 ) S - 169  2014

    J-GLOBAL

  • Achievement of peristaltic design in the artificial esophagus based on esophageal characteristic analysis of goats’ specimen

    Yasunori Taira, K. Kamiya, Y. Shiraishi, H. Miura, T. Shiga, M. O. Hashem, A. Yamada, Y. Tsuboko, T. Ito, K. Sano, D. Homma, T. Yambe

    IFMBE Proceedings   43   372 - 374  2014  [Refereed]

     View Summary

    © Springer International Publishing Switzerland 2014. In order to promote activity of daily life of patients with severe esophageal diseases, supporting peristalsis motion at the esophagus might be efficient. So we have been developing an artificial esophagus (AE) which has peristalsis motion function, and we have achieved the AE by using Ni-Ti shape memory alloy fibers. We extracted the esophagus from the epiglottis to the cardia potion from goats, which weighed 48.6±16.3 kg (n=4), after the animal experiment procedures. Prior to the measurement of characteristics of natural esophagus, we defined 5 segments in each extracted esophagus. Then we set the specimen in the static characteristic test apparatus in which we could measure segmental pressure-volume relations. Pressure and volume were measured simultaneously. All these measurement were performed within 3 hours from the extraction. Average length of each esophagus was 63±7cm. Because of the proximal segment of the specimen exhibited that the steeper increase of pressure than the distal portion near the cardia, we characterized that the distal esophagus is firmer than proximal. The proximal segment exhibited 55% bigger increase in pressure than the distal portion near the gastric cardiac part. Therefore it was suggested that compliance at the proximal portion could be lower at the small amount of internal volume. On the other hands, the extensibility of distal esophagus might be bigger than that at proximal segment. Consequently it was indicated that a new mechanical structure could be applied for the development of AE which could reproduce peristaltic motions.

    DOI

  • Improvement of a shape memory alloy fibered aortic pulsation device

    Mohamed O. Hashem, Y. Shiraishi, A. Yamada, Y. Tsuboko, H. Muira, T. Yambe, D. Homma

    IFMBE Proceedings   43   399 - 402  2014  [Refereed]

     View Summary

    © Springer International Publishing Switzerland 2014. Aim: We have been developing a new aortic blood flow support device using shape memory alloy (SMA) fibers as an actuator. The special features of the device were as follows: a) totally implantable design, b) small and foldable structure with actuators. The system could represent similar function of the aortomyoplasty and the extra aortic balloon pump at the ascending or descending installation. The purpose of this study was to improve the device as a non-blood contacting pulsation system, aiming at the application for the physiologically effective assistance in the artery. Material & Methods: We have designed the prototype by using covalent-type Ni-Ti SMA fibers which is capable of contracting around the aorta circumferentially. In this study, we developed a new structural design with oblique fiber orientations. The device consisted of rubber silicone wall plates, serially connected for radial contraction by the SMA fibers. We reduced the diameter of the contraction by the device. Then we tested the new structural design in the mock system, and examined its functional changes to optimize the mechanical structural design with SMA fibers. We demonstrated the radial deformation effect by using 150 micron Ni-Ti SMA fibers in a multiple circumferential oblique patterns. The orientation and length of the fibers were evaluated by the changes in oblique angles against the longitudinal axis. The fibers were secured circumferentially by using a pair of plastic grooved chambers, where the changes and contractile function was examined for each fiber Result: We could sandwich the aortic tubing of which the diameter was smaller than 30mm, under the constant pressure condition of the aortic tubing at 100mmHg Conclusion: we successfully achieved the improvement of the contraction effects of the SMA fibered device for aortic compression for smaller diameter vessels by the circumferential alignment by oblique angle of fibers.

    DOI

  • Modeling of signal transmissions in nerves in vitro for the development of a renal nerve cooling device for hypertension control

    Takuya Ito, H. Miura, T. Shiga, M. O. Hashem, K. Kamiya, A. Yamada, Y. Tsuboko, K. Sano, Y. Taira, Y. Shiraishi, H. Kumagai, T. Yambe

    IFMBE Proceedings   43   448 - 451  2014  [Refereed]

     View Summary

    © Springer International Publishing Switzerland 2014. Hyperactivity of the central nervous system may increase feedback gains in the hemodynamic system. We have been developing a totally implantable renal nerve cooling system which is capable of changing the hyperactive renal nerve function; in particular, those that reversibly eliminate excess signal-gains by using Peltier effects. In this study, we examined the effect of cooling on neurotransmission in vivo and in vitro. Then we evaluated functional characteristics of signal transmission by the change in thermal implication on the nerve to perform thermal sedation of nervous activity. After the animal experimental procedures, we examined the electrical signal transmission in the nerves extracted from the goats. Using the neurogram amplifier and the functional signal generator, we tested the signal transmission characteristics through the nerves and evaluated their filtering functions by regional nerve cooling. In order to examine of natural renal neurotransmission, the renal nerves were dissected from the left kidney in goats under the normal anesthesia using 2.5% of isoflurane. Aortic pressure and the neurogram were measured, and we applied the low-temperature exposure of the nerve. The electric signals exhibited filtered-transmission through the nerve by the cooling in vitro. In the goat’s experiment, the amplitude of the signal which was obtained at the renal nerve decreased when we decreased the nerve surface temperature by -15 degrees. Then we could evaluate these transmission functions of the renal nerve with the interactive changes of the temperature which was to be controlled by the cooling device. We examined characteristics of the signal transmission in the renal nerve in goats by cooling. And we could evaluate these changes in the functional transmission model with the thermal interactions.

    DOI

  • Design of a right ventricular simulator for the evaluation of artificial pulmonary valve

    Yusuke Tsuboko, S. Matsuo, Y. Shiraishi, H. Miura, A. Yamada, M. O. Hashem, T. Ito, K. Sano, Y. Taira, T. Akutsu, Z. Feng, M. Umezu, M. Yamagishi, Y. Saiki, T. Yambe

    IFMBE Proceedings   43   440 - 443  2014  [Refereed]

     View Summary

    © Springer International Publishing Switzerland 2014. Prosthetic materials are used for right ventricular outflow tract (RVOT) reconstruction in cases of congenital heart defects with right ventricular outflow hypoplasia or atresia and for pulmonary valve replacement in the Ross procedure. This procedure is to replace the stenotic pulmonary heart valve such as hypoplastic RVOT by the artificial valved conduit in infants. The authors have been developing a mechanical mock circulatory system for the evaluation of RVOT reconstruction. Improving the inflow characteristics of the right ventricular function and pulmonary circulatory hemodynamics was essentially necessary for more precise evaluation of newly designed heart valves. We developed an original pediatric pulmonary mechanical circulatory system, which was capable of simulating normal pulmonary hemodynamics in children. The system consists of a pneumatic-driven silicone right ventricle, a pneumatic-driven right atrium with a bileaflet polymer valve, a pulmonary valve chamber with a visualization port, a pulmonary arterial compliance tubing, a pulmonary peripheral resistance unit, and a venous reservoir. The mechanical interaction between the right atrium and ventricle was pneumatically controlled by the originally developed microcomputer. Transvalvular pressure waveforms were measured by the pressure transducers and the pulmonary flow was obtained at the outflow portion of right ventricle by the electromagnetic blood flow probe. As a result, hemodynamic waveforms of either the right ventricle or atrium were obtained at the revised pulmonary mock circulatory system. The characteristics with atrial kick were well simulated as the natural hemodynamics. Moreover we could examine the effects of the bulging sinus structure on the valve leaflet motion in the vicinity of the leaflet as well as the atrial contraction. In this study, we simulated natural hemodynamics in our pulmonary circulatory system. We concluded that the simulation of right atrial contraction was inevitable in the quantitative examination of right heart prosthetic valves for congenital heart failure.

    DOI

  • Improvement of a paediatric pulmonary mechanical circulatory system for the evaluation of right ventricular outflow tract reconstruction

    Yusuke TSUBOKO

    Tohoku University    2013.03  [Refereed]

  • Preliminary design of the mechanical circulation assist device for Fontan circulation using shape memory alloy fibers

    A. Yamada, Y. Shiraishi, T. K. Sugai, H. Miura, T. Shiga, M. O. Hashem, C. Koga, H. Hashimoto, Y. Tsuboko, T. Yambe, M. Yamagishi, D. Homma

    IFMBE Proceedings   39 IFMBE   119 - 121  2013  [Refereed]

     View Summary

    Fontan procedure is one of the common surgical treatment of congenital heart diseases. Patients with Fontan circulation have single ventricle in the systemic circulation with the total cavopulmonary connection. Pulmonary blood flow in the Fontan circulation is lower than in healthy subjects, and the central venous pressure may elevate. In this study, we developed a mechanical circulatory assist device for the extracardiac conduit for Fontan circulation and examined its driving method in the mock pediatric pulmonary circulatory system. We used shape memory alloy (SMA) fiber as an actuator of the device. The SMA actuator wrapped the extracardiac conduit between inferior vena cava and pulmonary artery. We designed two different types of the circulatory assist devices. We drove these devices in two different modes by the synchronized and sequential motions. The flow volume was 10mL/min against a load of 10mmHg, and the maximum contractile force indicated 60mmHg in the mock test. These results suggested the effective mechanical assistance for Fontan pulmonary circulation. © 2013 Springer-Verlag.

    DOI

  • Controlling methods of a newly developed extra aortic counter-pulsation device using shape memory alloy fibers

    Mohamed O. Hashem, A. Yamada, Y. Tsuboko, H. Muira, D. Homma, Y. Shiraishi, T. Yambe

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS   2013   2740 - 2743  2013  [Refereed]

     View Summary

    Diastolic counter-pulsation has been used to provide circulatory augmentation for short term cardiac support. The success of intra-aortic balloon pump (IABP) therapy has generated interest in long term counter-pulsation strategies to treat heart failure patients. The authors have been developing a totally implantable extra aortic pulsation device for the circulatory support of heart failure patients, using 150μm Ni-Ti anisotropic shape memory alloy (SMA) fibers. These fibers contract by Joule heating with an electric current supply. The special features of our design are as follow: non blood contacting, extra aortic pulsation function synchronizing with the native heart, a wrapping mechanical structure for the aorta in order to achieve its assistance as the aortomyoplsty and the extra aortic balloon pump. The device consisted of rubber silicone wall plates, serially connected for radial contraction. We examined the contractile function of the device, as well as it controlling methods; the phase delay parameter and the pulse width modulation, in a systemic mock circulatory system, with a pneumatically driven silicone left ventricle model, arterial rubber tubing, a peripheral resistance unit, and a venous reservoir. The device was secured around the aortic tubing with a counter-pulsation mode of 1-4 against the heartbeat. Pressure and flow waveforms were measured at the aortic outflow, as well as its driving condition of the contraction phase width and the phase delay. The device achieved its variable phase control for co-pulsation or counter-pulsation modes by changing the phase delay of the SMA fibers. Peak diastolic pressure significantly augmented, mean flow increased (p<0.05) according to the pulse width modulation. Therefore the newly developed extra aortic counter-pulsation device using SMA fibers, through it controlling methods indicated its promising alternative extra aortic approach for non-blood contacting cardiovascular circulatory support. © 2013 IEEE.

    DOI PubMed

  • Peristaltic hemodynamics of a new pediatric circulatory assist system for Fontan circulation using shape memory alloy fibers

    A. Yamada, Y. Shiraishi, H. Miura, T. Yambe, M. H. Omran, T. Shiga, Y. Tsuboko, D. Homma, M. Yamagishi

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS   2013   683 - 686  2013  [Refereed]

     View Summary

    Fontan procedure is one of the common surgical treatments of congenital heart diseases. Patients with Fontan circulation have single ventricle in the systemic circulation with the total cavopulmonary connection. We have been developing a pulmonary circulatory assist device using shape memory alloy fibers for Fontan circulation with total cavopulmonary connection. It consisted of the shape memory alloy fibers, the diameter of which are 100 μm. The fibers could wrap the ePTFE conduit for Fontan TCPC connection from the outside. We designed the sequential motion control system for sophisticated pulmonary hemodynamics by the pulsatile flow generation. In order to achieve pulsatile flow assistance in pulmonary arterial system, we fabricated a mechanical structure by sequential contraction of shape memory alloy fibers. Then, we developed a sequential contraction controller for the assist system, which could reproduce the wall contractile velocity at 6.0 to 20.0 cm/sec. We examined hemodynamic characteristic of its function using a mock circulatory system, which consisted of two overflow tanks representing venous and pulmonary arterial pressures in Fontan circulation. As a result, the pulmonary circulation assist device with sequential contraction could achieve effective promotion of the pulsatility in pulmonary arterial flow. © 2013 IEEE.

    DOI PubMed

  • Hemodynamic effects of pressure-volume relation in the atrial contraction model on the total artificial heart using centrifugal blood pumps

    Takuya Shiga, Takehito Kuroda, Yusuke Tsuboko, Hidekazu Miura, Yasuyuki Shiraishi, Tomoyuki Yambe

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS   2013   1815 - 1818  2013  [Refereed]  [International journal]

     View Summary

    Hemodynamic effects of atrial contraction with centrifugal pump type total artificial heart is unknown. In this study, we simulated an atrial contraction in a mock model. By the driving condition with higher pressure in the mock atrial model, the load during atrial contraction increased. Based on these findings, we examined atrial contraction in the animal using adult goats. Prior to the measurement, we installed a centrifugal-type ventricular assist device (VADs), and then clamped both ventricles. We measured the hemodynamic data without ventricular contractile functions in order to obtain the effect of atrial contraction on hemodynamics under the condition of the total artificial heart (TAH) circulatory support model. We could estimate the heart rate by revolution number and voltage of pumps. There might be a possibility that we could regulate autonomic nervous response with the control of cardiac output. © 2013 IEEE.

    DOI PubMed

  • Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function

    Ichiro Suzuki, Yasuyuki Shiraishi, Shota Yabe, Yusuke Tsuboko, Telma Keiko Sugai, Ken Matsue, Takeyoshi Kameyama, Yoshifumi Saijo, Takashi Tanaka, Yoshihiro Okamoto, Zhonggang Feng, Takako Miyazaki, Masaaki Yamagishi, Makoto Yoshizawa, Mitsuo Umezu, Tomoyuki Yambe

    Journal of Artificial Organs   15 ( 1 ) 49 - 56  2012.03  [Refereed]  [Domestic journal]

     View Summary

    The purpose of this study was to examine the hemodynamic characteristics of expanded polytetrafluoroethylene (ePTFE) pulmonary valves with bulging sinuses quantitatively in a pediatric pulmonary mechanical circulatory system designed by us, in order to propose the optimal design for clinical applications. In this study, we developed a pediatric pulmonary mock circulation system, which consisted of a pneumatic right ventricular model, a pulmonary heart valve chamber, and a pulmonary elastic compliance tubing with resistive units. The hemodynamic characteristics of four different types of ePTFE valves and a monoleaflet mechanical heart valve were examined. Relationships between the leaflet movements and fluid characteristics were evaluated based on engineering analyses using echocardiography and a high-speed video camera under the pediatric circulatory conditions of the mock system. We successfully performed hemodynamic simulations in our pediatric pulmonary circulatory system that could be useful for quantitatively evaluating the pediatric heart valves. In the simulation study, the ePTFE valve with bulging sinuses exhibited a large eddy in the vicinity of the leaflets, whereas the straight tubing exhibited turbulent flow. The Reynolds number obtained in the valve with bulging sinuses was calculated to be 1667, which was smaller than that in the straight tubing (R e = 2454). The hemodynamic characteristics of ePTFE pediatric pulmonary heart valves were examined in our mock circulatory system. The presence of the bulging sinuses in the pulmonary heart valve decreased the hydrodynamic energy loss and increased the systolic opening area. Based on an in vitro experiment, we were able to propose an optimal selection of pulmonary valve design parameters that could yield a more sophisticated pediatric ePTFE valve shape. © 2011 The Japanese Society for Artificial Organs.

    DOI PubMed

  • Study of hard-shell venous reservoir for bubble devices earthquake

    SUZUKI Ichiro, CHIBA Miki, TOMITA Motooki, MIYAMOTO Miyuki, TSUBOKO Yusuke, SHIRAISHI Yasuyuki, YAMBE Tomoyuki

    体外循環技術   39 ( 2 ) 153 - 158  2012

     View Summary

    人工心肺装置操作中に東日本大震災を経験した。地震体験車「ぐらら」を使用し、2種類のハードシェルタイプ静脈リザーバー(リザーバー)を用いて気泡発生の検証を行った。リザーバーには消泡部が最少貯血量より上部にあるタイプ(Q)と下部まで及ぶタイプ(R)のリザーバーにて検証した。気泡検出には、HATTELAND社製CMD20 Microbubble Detectorを用いリザーバー出口に装着し測定した。人工心肺装置(ソーリン社製S-III)を「ぐらら」に載せ、循環流量4L/minの条件にて測定、「ぐらら」の震度は震度5強、震度6強、震度7にて起震し、リザーバー液面レベルを1,500mL、1,000mL、500mLにて気泡混入の測定を行った。Qリザーバーでは、震度5強、液面レベル500mLにて10μmの気泡を検知し、震度6強、震度7、各液面設定にて20μmの気泡を検知した。Rリザーバーでは、震度7にて液面レベル500mLのみ10μmの気泡を検知し、1,500mL、1,000mLでは気泡は検知されなかった。また、Rリザーバーは、貯血量変動や液面からの気泡の引き込みは少なかった。(著者抄録)

    CiNii J-GLOBAL

  • 極細形状記憶合金線維の多層化による人工心筋システムの改良

    白石 泰之, 早津, 幸弘, 秋山, 正年, 北野, 智哉, 山田, 昭博, 坪子, 侑佑, 中島, 博行, 庄内, 千紘, 柏, 公一, 西條, 芳文, 齋木, 佳克, 本間, 大, 山家 智之

    人工臓器   41 ( 2 ) S - 135  2012

    J-GLOBAL

  • 小児人工肺動脈弁機能評価のための新しい右心系模擬循環回路開発

    坪子 侑佑, 鈴木, 一郎, 白石, 泰之, 山田, 昭博, 松尾, 諭志, 三浦, 英和, 西條, 芳文, 馮, 忠剛, 阿久津, 敏乃介, 梅津, 光生, 齋木, 佳克, 山家, 智之, 宮崎, 隆子, 山岸 正明

    人工臓器   41 ( 2 ) S - 148  2012

    J-GLOBAL

  • 小児用肺動脈弁開発のための生体弁機能のモデル循環計測・評価

    坪子 侑佑, 白石, 泰之, 山家, 智之, 松尾, 諭志, 齋木, 佳克, 馮, 忠剛, 梅津, 光生, 宮崎, 隆子, 山岸 正明

    バイオメカニズム学術講演会予稿集   33rd   215 - 216  2012

    J-GLOBAL

  • 生体僧房弁モデルを用いた力学検討に基づく人工乳頭筋設計

    橋本尚, 白石泰之, SugaiTelma, 志賀卓弥, 神谷蔵人, HashemMohamed, 北野智哉, 古賀千尋, 陳炯旬, 山田昭博, 坪子侑佑, 森谷葵, 三浦英和, 西條芳文, 山家智之, 本間大

    人工臓器   40 ( 2 ) S138 - S138  2011

    J-GLOBAL

  • 小児用新型肺動脈人工弁設計における最適化のための新しい設計の基礎検討

    坪子侑佑, 鈴木一郎, 白石泰之, SugaiTelma Keiko, 北野智哉, 山田昭博, 志賀卓弥, 神谷蔵人, 劉江箭, 三浦英和, 西條芳文, 山家智之, 松尾諭志, 齋木佳克, 梅津光生, 宮崎隆子, 山岸正明

    人工臓器   47th ( 2 ) S118 - S118  2011

    J-GLOBAL

  • 遠心ポンプ型全置換型人工心臓における拍動流の椎骨動脈と腎動脈血流測定

    志賀卓弥, 三浦英和, 陳炯旬, 白石泰行, 劉紅箭, SugaiTelma K, HashemMohamed Omran, 古賀千尋, 橋本尚, 山田昭博, 坪子侑佑, 森谷葵, 山家智之

    人工臓器   40 ( 2 ) S69 - S69  2011

    J-GLOBAL

▼display all

Misc

  • 生体医工学サマースクール2021実施報告

    桑名 健太, 木村 雄亮, 佐藤 裕一, 坪子 侑佑, 土井根 礼音, 前田 祐佳, 黒田 嘉宏, 永岡 隆, 西川 拓也, 朔 啓太, 荒船 龍彦

    生体医工学   59 ( 6 ) 185 - 187  2021.12

    DOI CiNii

  • 第4回Young Investigator's Awardの報告

    辛川 領, 前田 祐佳, 西川 拓也, 木阪 智彦, 坪子 侑佑, 木村 雄亮, 朔 啓太, 塩澤 成弘, 永岡 隆, 黒田 嘉宏, 荒船 龍彦

    生体医工学   59 ( 4-5 ) 127 - 130  2021.09

    DOI CiNii

  • 生体医工学会サマースクール2021開催案内

    桑名 健太, 木村 雄亮, 佐藤 裕一, 坪子 侑佑, 土井根 礼音, 朔 啓太, 荒船 龍彦

    生体医工学   59 ( 2-3 ) 80 - 80  2021.06

    DOI CiNii

  • Investigation of the relationship between flap mobility and false-lumen flow in an aortic dissection model using a pulsatile circulatory simulator

    伊佐地康佑, 坪子侑佑, 四方田直輝, 岩崎清隆

    LIFE講演概要集(CD-ROM)   2020/2021  2021  [Refereed]

    Research paper, summary (national, other academic conference)  

    J-GLOBAL

  • 冠動脈バイパス術におけるグラフト吻合部と狭窄部の位置関係の粒子画像流速計測法による血行力学的解析

    池原大烈, 坪子侑佑, 小原功, 新浪博士, 岩崎清隆, 岩崎清隆

    人工臓器(日本人工臓器学会)   50 ( 2 )  2021

    J-GLOBAL

  • 断層粒子画像流速計測法を用いた大動脈解離モデルにおける解離進展の力学的機序解明に関する基礎検討

    坪子侑佑, 伊佐地康佑, 許雪童, 四方田直輝, 岩崎清隆, 岩崎清隆, 岩崎清隆

    人工臓器(日本人工臓器学会)   50 ( 2 )  2021

    J-GLOBAL

  • Development of Three-Dimensional Strain Measurement Method for Coronary Artery Model Using Tomographic Particle Image Velocimetry

    坪子侑佑, XU Xuetong, 伊佐地康佑, 岩崎清隆

    日本機械学会年次大会講演論文集(CD-ROM)   2021  2021

    J-GLOBAL

  • ステントグラフト治療後の反射波増加は大動脈径に依存する ヤギ実験モデルにおけるwave intensityの評価

    高野 智弘, 高野 真澄, 坪子 侑佑, 白石 泰之, 山家 智之, 横山 斉

    脈管学   60 ( Suppl. ) S119 - S119  2020.10

  • 第3回Young Investigators Awardの報告

    木阪 智彦, 坪子 侑佑, 木村 雄亮, 朔 啓太, 辛川 領, 塩澤 成弘, 永岡 隆, 黒田 嘉宏, 荒船 龍彦

    生体医工学   58 ( 4-5 ) 188 - 191  2020.09

    DOI CiNii

  • 粒子画像流速計測法による弾性左冠動脈前下行枝モデルの血行力学的解析

    池原大烈, 坪子侑佑, 新浪博, 岩崎清隆

    人工臓器(日本人工臓器学会)   49 ( 3 ) S - 7  2020

    J-GLOBAL

  • Development of the circulatory simulator for generating coronary hemodynamics with microcirculation

    池原大烈, 坪子侑佑, 松原海斗, 服部薫, 新浪博士, 岩崎清隆

    日本生体医工学会大会プログラム・抄録集(Web)   59th ( Abstract ) 391 - 391  2020

     View Summary

    The left anterior descending coronary artery (LAD) compliance and hemodynamics changes after coronary artery bypass grafting and percutaneous coronary intervention are unclear. We have been developing a mock circulatory system for reproducing coronary hemodynamics including microcirculation. In this study, we newly developed the controlling mechanism of coronary vascular resistance. The simulator consists of roller pomp, silicone-made LAD and microvascular model, check valve and compliance tubing. We developed the linear motion mechanism for the reproduction of fluctuation of peripheral coronary artery resistance following ventricular contraction. As a result of the synchronization of two types of actuators, we obtained physiological coronary hemodynamics with 130/80(96) mmHg of the pressure and 370 ml/min of the mean flow rate. The simulated pressure waveform showed characteristic bimodal and large diastolic peak. For more sophisticated simulation, we are preparing the reproduction of interaction between coronary and systemic circulation and improving the controlling mechanism of coronary vascular resistance.

    DOI CiNii J-GLOBAL

  • Development of pulsatile circulatory system for measuring ascending aorta hemodynamics with 4D-MRI

    中間菜月, 服部薫, 服部薫, 高田淳平, 西村剛毅, 森脇涼, 川崎瑛太, 長尾充展, 後藤康裕, 坪子侑佑, 岩崎清隆, 岩崎清隆, 岩崎清隆

    日本生体医工学会大会プログラム・抄録集(Web)   59th ( Abstract ) 386 - 386  2020

     View Summary

    Bicuspid aortic valve disease is a common congenital valvular disease. There are several variations in valve morphology and its relationship with ascending aortic dilation is not clear. In this study, we newly developed a pulsatile circulatory system to investigate flow in ascending aorta using 4D-MRI. The simulator consists of the silicone-made left ventricle, aortic valve chamber, aortic arch, compliance tank, and reservoir. The aortic valve model was fabricated using bovine aorta and pericardium and installed in the valve chamber. Pulsatile pressure and flow were pneumatically generated and controlled by peripheral resistive unit. A tricuspid aortic valve model was investigated by 4D-MRI. In the ascending aorta, straight flow was observed in early-systole and physiological clockwise-twisted flow was observed in late-systole respectively. Therefore, the pulsatile circulatory system developed in this study can be useful for revealing the relationship between bicuspid valve morphology and flow pattern in ascending aorta.

    DOI CiNii J-GLOBAL

  • カテーテルデバイスの開発促進のための非臨床研究

    坪子侑佑, 岩崎清隆, 岩崎清隆, 岩崎清隆

    人工臓器(日本人工臓器学会)   49 ( 2 ) S - 69  2020  [Invited]

    Authorship:Lead author

    J-GLOBAL

  • 腹部大動脈用ステントグラフトの不具合報告情報を用いたファンネルプロットによる可視化と詳細分析の試み

    坪子 侑佑, 松橋 祐輝, 宿澤 孝太, 笠貫 宏, 岩崎 清隆

    人工臓器   48 ( 2 ) S - 221  2019.10

  • Minimally invasive aortic valve procedures: MICS, sutureless valve, and TAVI Patient-data based experimental simulator for developing and investigating effective use of transcatheter aortic valve

    Iwasaki Kiyotaka, Maebara Rumi, Sasuga Saeko, Ai Ryunosuke, Tsuboko Yusuke, Tanaka Yutaka, Yamawaki Masahiro, Umezu Mitsuo

    人工臓器   48 ( 2 ) S - 50  2019.10

  • 生体吸収性スキャフォールドを対象とした日米間の不具合報告件数の比較分析

    松橋 祐輝, 坪子 侑佑, 岩崎 清隆, 笠貫 宏

    人工臓器   48 ( 2 ) S - 203  2019.10

  • 解離性大動脈瘤におけるステントグラフト留置前後の偽腔内流れの可視化

    中村 和磨, 宿澤 孝太, 坪子 侑佑, 梅津 光生, 大木 隆生, 岩崎 清隆

    生活生命支援医療福祉工学系学会連合大会講演要旨集   2019   33 - 33  2019.09

  • 経カテーテル大動脈弁における弁葉周辺および冠動脈開口部流れの可視化のための拍動循環シミュレータ開発

    坪子 侑佑, 藍 龍之介, 前原 瑠海, 許 雪童, 岩崎 清隆

    日本バイオレオロジー学会誌(B&R)   33 ( 2 ) 50 - 50  2019.06

  • ベンチスタディの結果に基づく左主幹部ステント留置術を成功させるための要件(The Requirements for Successful Left Main Stenting from the Results of the Bench Study)

    挽地 裕, Matsubara Kaito, Sugiyama Kouta, Zhu Xiaodong, Tsuboko Yusuke, Matsuhashi Yuki, Yatsunami Yuki, Chen Wennhan, Sawami Kosuke, Kamishita Kohei, Kaneko Tetsuya, Hongo Hiroshi, Inoue Yohei, Kajiwara Masataka, Uchino Masumi, Yajima Ayumu, Tago Motoko, Sakamoto Yoshiko, Natsuaki Masahiro, Node Koichi, Iwasaki Kiyotaka

    日本循環器学会学術集会抄録集   83回   ML01 - 2  2019.03

  • 経カテーテル大動脈弁における弁葉周辺および冠動脈開口部流れの可視化のための拍動循環シミュレータ開発

    坪子侑佑, 藍龍之介, 前原瑠海, 許雪童, 岩崎清隆

    日本バイオレオロジー学会誌(Web)   33 ( 2 ) 38  2019  [Refereed]

    J-GLOBAL

  • Experimental investigation of influence of stent designs and sizes on stent apposition using a left main coronary artery bifurcation model

    松原海斗, 挽地裕, 杉山航太, 伊藤遼太, ZHU Xiaodong, 坪子侑佑, 松橋祐輝, 梅津光生, 岩崎清隆

    バイオエンジニアリング講演会講演論文集(CD-ROM)   32nd   1E23  2019

    DOI CiNii J-GLOBAL

  • Development of an accelerated durability tester for a transcatheter aortic valve using calcified aortic valve model

    前原瑠海, 藍龍之介, 坪子侑佑, 梅津光生, 岩崎清隆

    バイオエンジニアリング講演会講演論文集(CD-ROM)   32nd   1E33  2019

    DOI CiNii J-GLOBAL

  • 生体吸収性スキャフォールドを対象とした日米間の不具合報告件数の比較分析

    松橋祐輝, 坪子侑佑, 坪子侑佑, 岩崎清隆, 岩崎清隆, 笠貫宏

    人工臓器(日本人工臓器学会)   48 ( 2 ) S - 203  2019

    J-GLOBAL

  • 腹部大動脈用ステントグラフトの不具合報告情報を用いたファンネルプロットによる可視化と詳細分析の試み

    坪子侑佑, 坪子侑佑, 松橋祐輝, 松橋祐輝, 宿澤孝太, 宿澤孝太, 笠貫宏, 岩崎清隆, 岩崎清隆

    人工臓器(日本人工臓器学会)   48 ( 2 ) S - 221  2019

    J-GLOBAL

  • 解離性大動脈瘤に対するステントグラフト留置前後の偽腔内流れの可視化

    中村和磨, 赤岡拓, 宿澤孝太, 坪子侑佑, 松原海斗, 藍龍之介, 梅津光生, 岩崎清隆

    日本生体医工学会大会プログラム・抄録集(Web)   58th ( 0 ) S47_2 - S47_2  2019

    DOI CiNii J-GLOBAL

  • 経カテーテル大動脈弁留置後の弁の周方向相対角が異なる大動脈モデルにおけるバルサルバ洞内の血流

    藍龍之介, 坪子侑佑, 流石朗子, 前原瑠海, 松原海斗, 中村和磨, 梅津光生, 岩崎清隆

    日本生体医工学会大会プログラム・抄録集(Web)   58th ( 0 ) S168_1 - S168_1  2019

    DOI CiNii J-GLOBAL

  • 先進的医療機器の効率的開発を促進する患者を模した非臨床試験系の開発

    岩崎清隆, 松橋祐輝, 坪子侑佑, 朱暁冬, 高田淳平, 笠貫宏, 梅津光生

    日本生体医工学会大会プログラム・抄録集(Web)   58th ( 0 ) S13_2 - S13_2  2019

    DOI CiNii J-GLOBAL

  • 医療レギュラトリーサイエンス分野の専門人材の育成の現況

    梅津光生, 岩崎清隆, 松橋祐輝, 坪子侑佑, 笠貫宏

    日本生体医工学会大会プログラム・抄録集(Web)   58th ( 0 ) S11_2 - S11_2  2019

    DOI CiNii J-GLOBAL

  • 不具合報告情報の活用に向けた大動脈用ステントグラフトに関する不具合報告記載内容と公開情報の分析

    宿澤孝太, 松橋祐輝, 松橋祐輝, 坪子侑佑, 青木郁香, 飯嶋一雄, 笠貫宏, 梅津光生, 梅津光生, 岩崎清隆, 岩崎清隆

    レギュラトリーサイエンス学会誌   8 ( Supplement )  2018

    J-GLOBAL

  • 不具合報告情報の活用に向けた生体吸収性冠動脈スキャフォールドに関する日米の不具合報告内容の分析

    松橋祐輝, 松橋祐輝, 宿澤孝太, 坪子侑佑, 青木郁香, 飯嶋一雄, 挽地裕, 挽地裕, 笠貫宏, 梅津光生, 梅津光生, 岩崎清隆, 岩崎清隆

    レギュラトリーサイエンス学会誌   8 ( Supplement )  2018

    J-GLOBAL

  • [title in Japanese]

    Iwasaki Kiyotaka

    Transactions of Japanese Society for Medical and Biological Engineering   56 ( 0 ) S11 - S11  2018

     View Summary

    <p>Developing advanced medical devices and treatments within affordable costs and expediting patients' access to such medical therapies are expected in worldwide.</p><p> In the development of medical devices, identification, evaluation, and reduction of individual risks are indispensable in parallel with evaluation of probable benefits. Effects of patent characteristics and doctor's skill should be considered to maximize device performances and reduce risks. Clinical trials for market approval of innovative and first-in-human medical devices are limited in inclusion criteria, number of patient enrollment, and monitoring period. Thus, we have been challenging to develop innovative patient-oriented testing methodologies to accelerate medical device development, to evaluate safety and probable efficacy of medical devices, and to support scientific-based approval decision, which, we believe, will contribute to the acceleration of patients' access to new technologies. We are also engaged in developing guidance and standards to evaluate innovative medical devices and driving those global expansions.</p>

    DOI CiNii

  • Cardiovascular Biomaterials 革新的医療機器の早期承認のためのバイオエンジニアの役割

    梅津 光生, 岩崎 清隆, 松橋 祐輝, 坪子 侑佑, 笠貫 宏

    日本バイオマテリアル学会大会予稿集   40th   159 - 159  2018

    J-GLOBAL

  • Difficulties of human resources at PhD course on medical regulatory science

    Umezu Mitsuo, Iwasaki Kiyotaka, Iseki Hiroshi, Matsuhashi Yuki, Tsuboko Yusuke, Kasanuki Hiroshi

    Transactions of Japanese Society for Medical and Biological Engineering   57th ( 0 ) S218 - 2-S218-2  2018

    DOI CiNii J-GLOBAL

  • Establishment of the Waseda Institute for Medical Regulatory Science

    UMEZU MITSUO, IWASAKI KIYOTAKA, MATSUHASHI YUKI, TSUBOKO YUSUKE, MURAGAKI YOSHIHIRO, ISEKI HIROSHI, KASANUKI HIROSHI

    Transactions of Japanese Society for Medical and Biological Engineering   57th ( 0 ) S8 - S8  2018

     View Summary

    <p>A unique and major challenge to the development of advanced medical devices is adjusting the criteria for determining value among diverse interested parties that may include academia, industrialists, governments as well as patients. Hence, the pressure to harmonize scientific and ethical standards to allow the proper judgements to be made in different circumstances co-exists with the need to establish and develop reliable evaluation techniques. Waseda Institute for Medical Regulatory Science, founded in 2015, approaches these issues from a comprehensive perspective by performing tasks that range from formulating guidelines for advanced medical treatment, based on the foundations of life and medical sciences or medical engineering, to developing professional human resources. In parallel, we jointly established a graduate school for the Cooperative Major in Advanced Biomedical Sciences (Doctoral Program) specializing in medical regulatory science between Waseda University and Tokyo Women's Medical University.</p>

    DOI CiNii J-GLOBAL

  • 経カテーテル大動脈弁の弁葉周辺流れ計測のための冠血流を考慮した拍動循環シミュレータの開発

    坪子侑佑, 藍龍之介, 流石朗子, 前原瑠海, 梅津光生, 梅津光生, 岩崎清隆, 岩崎清隆

    人工臓器(日本人工臓器学会)   47 ( 2 ) S - 85  2018

    J-GLOBAL

  • 先天性心不全に対する新規Fontan clipの試験のための模擬肺循環システム(Mock pulmonary circulatory system for the examination of a new Fontan clip for congenial heart failure)

    軽部 雅人, 白石 泰之, 山田 昭博, 坪子 侑佑, 中畑 碧, 山家 智之

    人工臓器   46 ( 2 ) S - 176  2017.08

  • Fundamental Study of Cooling System for Pulmonary Circulation Assist Device by Using Heat-Pipe

    Yamada Akihiro, Tomoyuki Yambe, Okajima Jyunnosuke, Inoue Yusuke, Taira Yasunori, Ikeda Jyunpei, Yuba Mitsuru, Shiraishi Yasuyuki, Tsuboko Yusuke, Arakawa Tomoya

    Trans. jpn. Soc. Med. Bio. Eng   56th ( 3 ) 235 - 235  2017

     View Summary

    &lt;p&gt;We have been developed a pulmonary circulatory assist device for pediatric patients to promote hemodynamics of Fontan circulation. In this study, in order to develop the cooling system for a pulmonary circulatory assist device by heat pipes, we examined heat transfer response of the device, and we also designed basically heat transfer system by using heat pipes. In the animal experimental model, hot spot of during device contraction was around 45 degree Celsius in the rigid support sheath area. Whereas, there were no thermal elevation in extra cardiac conduit. From the temperature difference between the maximum device temperature and the blood temperature, we considered to be selecting the sealed gas and the filling pressure for heat pipe design. In the future prospects, we are due to develop prototype cooling system by waste heat to the blood vessel with heat pipe.&lt;/p&gt;

    CiNii J-GLOBAL

  • 食物運搬機能を有する人工食道ステント開発のための非線形粘弾性モデルを用いた生体力学的特性解析

    平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, FENG Zhonggang, 山家智之, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   46 ( 1 ) 34 - 34  2017

    J-GLOBAL

  • Fontan循環クリップ開発のための設計構成要素の基礎検討

    池田純平, 白石泰之, 坪子侑佑, 平恭紀, 山田昭博, 井上雄介, 山岸正明, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   46 ( 1 ) 35 - 35  2017

    J-GLOBAL

  • Improvement of the implantable renal nerve cooling device and examine the effect of cooling for nerve activity

    Yuba Mitsuru, Nakagata Hiroshi, Shiraishi Yasuyuki, Inoue Yusuke, Yamada Akihiro, Tsuboko Yusuke, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering   56th ( 3 ) 236 - 236  2017

     View Summary

    <p>The purpose of this study was to improve an implantable renal nerve cooling device which was capable of regulating the surface temperature of the renal nerve in hypertensive patients. We used a Peltier elements and performed a component design combined with a heat pipe for the implantable device as a proof of concept. The implantable device was composed two components: a) a Peltier element having 3.94 mm thickness with a rectangular cooling plate of 3.2 mm x 3.2 mm, b) a heat pipe having 6 mm diameter with 250 mm length, which was to be mechanically and thermally connected to the radiation surface of the Peltier element. We examined the surface cooling effects by a thermal camera against the several power supply conditions for the Peltier element. As a result, the cooling surface showed the controllable temperature by the electric power supply with the heat-pipe unit without any radiation fluids.</p>

    DOI CiNii J-GLOBAL

  • Development of Valve Test System for Evaluating the Pulmonary Trileaflet Motion

    Tsuboko Yusuke, Shiraishi Yasuyuki, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering   56th ( 3 ) 233 - 233  2017

     View Summary

    <p>An expanded polytetrafluoroethylene (ePTFE) pulmonary conduit valve is commonly used for the pulmonary valve reconstruction in patients with congenital heart failure. The special features of the valve are fan-shaped leaflets and the bulging sinus which is representing the Valsalva shape. The purpose of this study was to compare valvular motion in the newly designed pulmonary valve tester.To investigate valvular function under the low-pressure pulmonary hemodynamic condition, we used two different types of ePTFE leaflets and examined their characteristics by using a high-speed camera. Each 0.1 mm-thick leaflet with different cusp depth was installed in the conduit valve holder. The holder was connected to a linear actuator. We compared the relationships between leaflet motion and annular displacement.We could achieve the comparison of leaflet motion with different cusp, and it was suggested that the cusp depth might be an important parameter to optimize the coaptation zone in ePTFE pulmonary valves.</p>

    DOI CiNii J-GLOBAL

  • Analysis of swallowing motion by using non-contact 3-D skin deglutition measurement

    Taira Yasunori, Shiraishi Yasuyuki, Inoue Yusuke, Yamada Akihiro, Tsuboko Yusuke, Arakawa Tomoya, Yuba Mitsuru

    Transactions of Japanese Society for Medical and Biological Engineering   56th ( 5 ) 481 - 481  2017

     View Summary

    <p>Evaluation of swallowing motion is necessary for preventing aspiration pneumonia. MRI and sound analyses are recent deglutition diagnoses, however, these are inherently susceptible to noise. We focused on the detection of skin motion around pharyngeal portion, and examined the feasibility of information measured by a depth camera. Firstly, we measured the pharyngeal portion in healthy subjects during the process of drinking water or saline. Secondly, we measured the pharyngeal skin during eating process of a piece of bread pasted with oil or with high viscosity gelatin. Results were as follows: a) we obtained the prospective self-gating of swallowing using depth information, b) the measurement is available for frequency analysis of the gating, and c) the deglutition was associated with the taste with respect to the sensory inspection. Consequently, periodical measurements by the 3-D depth camera might be useful for the selection of profiles corresponding to food intake including individual preferences.</p>

    DOI CiNii J-GLOBAL

  • 高齢者の嚥下・蠕動機能を非侵襲的に定量診断する解析装置の世界初の発明

    山家 智之, 白石 泰之, 井上 雄介, 山田 昭博, 坪子 侑佑

    研究結果報告書集 : 交通安全等・高齢者福祉   23   125 - 129  2017

    CiNii

  • 胸部および腹部大動脈ステントグラフト内挿術の心血管機能に及ぼす影響

    高野智弘, 白石泰之, 荒川友哉, 坪子侑佑, 高野真澄, 横山斉

    福田記念医療技術振興財団情報   ( 30 ) 117 - 121  2017

    Internal/External technical report, pre-print, etc.  

     View Summary

    ステントグラフト治療を受けた患者の長期予後を改善するため、ステントグラフト留置による心血管機能への影響を調べ、遠隔期に起きる心血管イベントとの関連について検討した。大型実験動物(ヤギ/日本ザーネン種)を対象に、ステントグラフト挿入術を行い、留置前後の心血管機能のパラメータを測定した。また、留置部位(胸部:近位と腹部:遠位)による血管機能パラメータの変動における違いについて検討した。その結果、使用したヤギは9頭(近位留置例5例、遠位留置例4例)であった。遠位および近位にステンドグラフトを留置した時の前後の左室圧波形と大動脈血流速度波形の変化は、遠位留置例で増大する傾向を認めた。収縮早期及び収縮末期における平均仕事量を算出したところ、収縮期末期において、遠位留置例で増加傾向を認めた。

    CiNii J-GLOBAL

  • 小児用ePTFE製肺動脈弁の弁葉およびbulging sinusが弁機能へ及ぼす影響の基礎検討

    坪子侑佑, 武良盛太郎, 白石泰之, 山田昭博, 山岸正明, 山家智之

    人工臓器(日本人工臓器学会)   45 ( 1 ) 40 - 40  2016

    J-GLOBAL

  • ePTFE製肺動脈弁の弁挙動解析の基礎検討

    武良盛太郎, 坪子侑佑, 白石泰之, 三浦英和, 山岸正明, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   45 ( 1 ) 41 - 41  2016

    J-GLOBAL

  • 非臨床試験および前臨床試験手法を用いた心臓血管系診断に対する科学的アプローチ

    井上雄介, 白石泰之, 山田昭博, 坪子侑佑, 平恭紀, 池田純平, 荒川友哉, 弓場充, 山家智之, 山家智之

    日本統合医療学会誌   9 ( 3 ) 304 - 304  2016

    J-GLOBAL

  • 脈波診断に医工学的根拠を付与する定量的評価手法の開発

    山田昭博, 坪子侑佑, 井上雄介, 平恭紀, 白石泰之, 関隆志, 山家智之

    日本統合医療学会誌   9 ( 3 ) 305 - 305  2016

    J-GLOBAL

  • 動脈系末梢部の医工学的モデリングによる血圧血流応答

    坪子侑佑, 白石泰之, 山家智之

    日本統合医療学会誌   9 ( 3 ) 305 - 305  2016

    J-GLOBAL

  • 食感特性評価のための嚥下挙動解析

    平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 山家智之

    日本統合医療学会誌   9 ( 3 ) 306 - 306  2016

    J-GLOBAL

  • 生体内組織の局所温度調節による血圧制御の医工学的基礎検討

    弓場充, 中潟寛, 白石泰之, 山田昭博, 井上雄介, 坪子侑佑, 平恭紀, 池田純平, 荒川友哉, 山家智之

    日本統合医療学会誌   9 ( 3 ) 382 - 382  2016

    J-GLOBAL

  • 東洋医学における脈診計測評価のための模擬循環回路の開発

    齋藤大, 小林由佳, 渡邉健太郎, 坪子侑佑, 白石泰之, 荒川友哉, 山田昭博, 井上雄介, 平恭紀, 池田純平, 弓場充, 山家智之

    日本統合医療学会誌   9 ( 3 ) 383 - 383  2016

    J-GLOBAL

  • 左心循環補助時における心房細動が脈診計測へ及ぼす影響の基礎検討

    小林由佳, 齋藤大, 渡邉健太郎, 白石泰之, 坪子侑佑, 弓場充, 山田昭博, 井上雄介, 平恭紀, 池田純平, 荒川友哉, 山家智之

    日本統合医療学会誌   9 ( 3 ) 383 - 383  2016

    J-GLOBAL

  • 補助人工心臓のポンプ性能差異による末梢脈波変化についての考察

    渡邉健太郎, 齋藤大, 小林由佳, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 平恭紀, 池田純平, 荒川友哉, 弓場充, 山家智之

    日本統合医療学会誌   9 ( 3 ) 384 - 384  2016

    J-GLOBAL

  • 電力制御によるFontan循環補助装置のための収縮制御モニタリングシステムの構築

    山田昭博, 三浦英和, 白石泰之, 坪子侑佑, 坪子侑佑, 平恭紀, 池田純平, 本間大, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   45 ( 2 ) S - 92  2016

    J-GLOBAL

  • 小児用ePTFE製肺動脈弁付導管の形状改良のための静圧負荷逆流特性計測

    坪子侑佑, 坪子侑佑, 白石泰之, 山田昭博, 平恭紀, 平恭紀, 池田純平, 山岸正明, 山家智之

    人工臓器(日本人工臓器学会)   45 ( 2 ) S - 150  2016

    J-GLOBAL

  • ステントグラフト内挿術における血流変動時の後負荷評価のための循環シミュレーションによる基礎検討

    荒川友哉, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 佐々木一益, 平恭紀, 池田純平, 高野智弘, 高野真澄, 横山斉, 山家智之

    人工臓器(日本人工臓器学会)   45 ( 2 ) S - 151  2016

    J-GLOBAL

  • Fontan循環クリップ開発のための設計構成要素の基礎検討

    池田純平, 白石泰之, 坪子侑佑, 平恭紀, 山田昭博, 井上雄介, 山岸正明, 山家智之, 本間大

    人工臓器(日本人工臓器学会)   45 ( 2 ) S - 151  2016

    J-GLOBAL

  • 皮膚組織を貫通する人工物の癒着強度評価試験のための基礎検討

    弓場充, 坪子侑佑, 白石泰之, 井上雄介, 平恭紀, 太田信, 山家智之

    人工臓器(日本人工臓器学会)   45 ( 2 ) S - 159  2016

    J-GLOBAL

  • 食物運搬機能を有する人工食道ステント開発のための非線形粘弾性モデルを用いた生体力学的特性解析

    平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   45 ( 2 ) S - 161  2016

    J-GLOBAL

  • 医療用ハイブリッド材料の滅菌に関する研究

    井上雄介, 田代彩夏, 磯山隆, 斎藤逸郎, 阿部裕輔, 白石泰之, 山田昭博, 坪子侑佑, 原伸太郎, 圦本晃海, 三浦英和, 山家智之

    LIFE講演概要集(CD-ROM)   2016   067 - 069  2016

    J-GLOBAL

  • 血管ステント治療における心機能の後負荷評価モデル構築の試み

    荒川友哉, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 平恭紀, 佐々木一益, 渡辺祥太, 池田純平, 弓場充, 山家智之, 高野智弘, 高野真澄, 横山斉

    LIFE講演概要集(CD-ROM)   2016   070 - 072  2016

    J-GLOBAL

  • 高精度な血液循環模擬による右心循環補助デバイスの医工学評価

    坪子侑佑, 白石泰之, 山田昭博, 平恭紀, 井上雄介, 佐々木一益, 渡辺祥太, 池田純平, 荒川友哉, 弓場充, 山家智之

    LIFE講演概要集(CD-ROM)   2016   470 - 471  2016

    J-GLOBAL

  • 高血圧治療を目的とした埋込型腎神経冷却デバイスの改良

    弓場充, 白石泰之, 中潟寛, 山田昭博, 坪子侑佑, 井上雄介, 佐々木一益, 平恭紀, 渡辺祥太, 池田純平, 荒川友哉, 山家智之

    LIFE講演概要集(CD-ROM)   2016   745 - 747  2016

    J-GLOBAL

  • Design and evaluation of a newly developed Fontan clip

    Ikeda Jumpei, Yambe Tomoyuki, Shiraishi Yasuyuki, Yamada Akihiro, Tsuboko Yusuke, Taira Yasunori, Suzuki Takuji, Inoue Yusuke, Homma Dai, Yamagishi Masaaki

    Transactions of Japanese Society for Medical and Biological Engineering   55th ( 26 ) S16 - S16  2016

    DOI CiNii J-GLOBAL

  • Hemodynamic examination for shape optimization of ePTFE valved conduit with bulging sinuses

    Tsuboko Yusuke, Shiraishi Yasuyuki, Miura Hidekazu, Inoue Yusuke, Yamada Akihiro, Taira Yasunori, Ikeda Jumpei, Yamagishi Masaaki, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering   55th ( 26 ) S54 - S54  2016

    DOI CiNii J-GLOBAL

  • Newly development of implantable Fontan circulation assist device

    Yamada Akihiro, Yambe Tomoyuki, Shiraishi Yasuyuki, Miura Hidekazu, Taira Yasunori, Tsuboko Yusuke, Ikeda Jyunpei, Inoue Yusuke, Yamagishi Masaaki, Homma Dai

    Transactions of Japanese Society for Medical and Biological Engineering   55th ( 26 ) S52 - S52  2016

    DOI CiNii J-GLOBAL

  • Biomechanical characteristic analysis of natural esophageal using a non-liner viscoeolastic model

    Taira Yasunori, Mura Seitaro, Ikeda Jumpei, Homma Dai, Yambe Tomoyuki, Shiraishi Yasuyuki, Miura Hidekazu, Inoue Yusuke, Sasaki Kazumasu, Yamada Akihiro, Tsuboko Yusuke, Suzuki Takuji, Hagio Yuki

    Transactions of Japanese Society for Medical and Biological Engineering   55th ( 28 ) S347 - S347  2016

    DOI CiNii J-GLOBAL

  • 完全埋め込み型高血圧治療装置

    山家智之, 白石泰之, 鈴木拓志, 井上雄介, 山田昭博, 坪子侑佑

    循環制御(Web)   37 ( 3 ) 185 - 189  2016

    DOI CiNii J-GLOBAL

  • Behavior pattern and the Autonomic function of the cardiovascular system in the subjects with functional food intake

    山家智之, 吉澤誠, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑

    飯島藤十郎記念食品科学振興財団年報   31   272 - 279  2016

    Internal/External technical report, pre-print, etc.  

    CiNii J-GLOBAL

  • 環境温度変化における遠心型補助人工心臓駆動時の心臓血管系の応答解析

    武良盛太郎, 白石泰之, 山田昭博, 三浦英和, 坪子侑佑, 佐野恭介, 平恭紀, 鈴木拓志, 萩尾勇樹, 渡辺祥太, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   44 ( 1 ) 29 - 29  2015

    J-GLOBAL

  • 右心バイパス血流路を有する動物実験モデルによる小児用肺循環補助装置の血行動態評価

    山田昭博, 山田昭博, 白石泰之, 三浦英和, 坪子侑佑, 坪子侑佑, 平恭紀, 井上雄介, 山岸正明, 本間大, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   44 ( 2 ) S - 99  2015

    J-GLOBAL

  • CCDを用いた埋め込み型小型肺循環血流観察デバイス開発のための基礎検討

    渡辺祥太, 白石泰之, 三浦英和, 井上雄介, 坪子侑佑, 平恭紀, 山家智之, 渡辺祥太, 白石泰之, 三浦英和, 井上雄介, 山田昭博, 坪子侑佑, 平恭紀, 山家智之

    人工臓器(日本人工臓器学会)   44 ( 2 ) S - 172  2015

    J-GLOBAL

  • 右心循環用に用いる人工心臓用モータの性能評価

    萩尾勇樹, 三浦英和, 白石泰之, 片平晋太郎, 佐々木一益, 山田昭博, 坪子侑佑, 平恭紀, 平恭紀, 山家智之

    人工臓器(日本人工臓器学会)   44 ( 2 ) S - 173  2015

    J-GLOBAL

  • 小児用ePTFE製肺動脈弁の弁葉およびbulging sinusが弁機能へ及ぼす影響の基礎検討

    坪子侑佑, 白石泰之, 武良盛太郎, 山田昭博, 山岸正明, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   44 ( 2 ) S - 174  2015

    J-GLOBAL

  • ePTFE製肺動脈弁の弁挙動解析の基礎検討

    武良盛太郎, 白石泰之, 坪子侑佑, 三浦英和, 山岸正明, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   44 ( 2 ) S - 175  2015

    J-GLOBAL

  • 本態性高血圧治療を目的とした腎神経活動制御のための埋め込み型腎神経冷却装置の基礎検討

    鈴木拓志, 白石泰之, 三浦英和, 山田昭博, 坪子侑佑, 平恭紀, 井上雄介, 山家智之, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   44 ( 2 ) S - 185  2015

    J-GLOBAL

  • 食物運搬機能を有する人工食道のための嚥下検知システムの設計開発

    平恭紀, 白石泰之, 三浦英和, 井上雄介, 佐々木一益, 山田昭博, 山田昭博, 坪子侑佑, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 本間大, 山家智之

    人工臓器(日本人工臓器学会)   44 ( 2 ) S - 185  2015

    J-GLOBAL

  • The evaluation of motor characteristics of the total artificial heart by the change in the rotor to stator gap

    HAGIO YUUKI, MIURA HIDEKAZU, SHIRAISHI YASUYUKI, SHIGA TAKUYA, YAMADA AKIHIRO, TSUBOKO YUSUKE, SANO KYOSUKE, TAIRA YASUNORI, YAMBE TOMOYUKI

    Transactions of Japanese Society for Medical and Biological Engineering   53 ( 0 ) S198_02 - S198_02  2015

     View Summary

    In the development of total artificial heart (TAH), we must design left and right pumps separately to achieve a proper flow balance. In this study, we designed a motor of pump to maintain right heat circulation and prototyped. The Motor was designed by using Assumptive Magnetic Flux Path Method. We made equivalent circuit by this method, and evaluated synthetic reluctance, magnetic flux of gap for the purpose of inhibiting magnetic saturation. We adopted structure of DC brushless, four poles and 12 slots. We assumed the pump efficiency was 50%.We set maximum amount of cardiac output was 10L/min, maximum pressure was 20mmHg when rotation number was 3000rpm.In measurement, we examined the effect of gap difference, we changed the gap was 1.0 mm and 1.5 mm respectively. Result of measurement, torque and speed constants was 55 mNm/A and 180 rpm/V, 51 mNm/A and 198 rpm/V when the gap difference was 1.0 mm and 1.5 mm respectively. We confirmed the characteristics of the motor tend to high torque when the gap is narrow. On the other hand, it tends to high revolution when the gap is wide.

    DOI CiNii

  • Preliminary study for the development of a sophisticated pulmonary vascular resistance model

    TSUBOKO YUSUKE, WATANABE SYOTA, SHIRAISHI YASUYUKI, MIURA HIDEKAZU, YAMADA AKIHIRO, SUZUKI TAKUJI, TAIRA YASUNORI, YAMBE TOMOYUKI

    Transactions of Japanese Society for Medical and Biological Engineering   53 ( 0 ) S200_01 - S200_01  2015

     View Summary

    The authors have been developing a pulmonary mechanical simulator in order to establish a design parameters of a novel artificial cardiovascular devices. In pulmonary circulation, interactive pressure-flow changes are regulated by pulmonary impedance characteristics. We focused on the native impedance characteristics variation in the pulmonary circulation. To examine the effect of respiratory control on pulmonary resistance, we measured pulmonary arterial pressure and flow in adult goat under the different respiratory settings with open/closed-chest condition. Pulmonary input impedance in two respiratory conditions under the anesthetized open-chest positive pressure ventilation (PPV) and the awake spontaneous respiration (SR) were calculated. Longitudinal impedance at 0 Hz in SR showed lower than in PPV, and at high harmonic area in SR was bigger than in PPV. In order to examine the hemodynamic response for newly designed artificial internal organs, pulmonary impedance variation caused by respiratory control should be considered. For sophisticated pulmonary resistance model, reproducing the negative pressure condition in the thoracic cavity, and pulmonic vascular resistance regulation might be required.

    DOI CiNii

  • Examination of pediatric pulmonary circulation assist device based on Fontan circulation animal experimental model

    YAMADA AKIHIRO, Shiraisihi Yasuyuki, Miura Hidekazu, Tsuboko Yusuke, Taira Yasunori, Sano Kyosuke, Yamagishi Masaaki, Homma Dai, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering   53 ( 0 ) S201_01 - S201_01  2015

     View Summary

    Fontan procedure is the final palliative surgical operation in pediatric patients with congenital heart disease. After Fontan procedure, there is non-pulsatile flow in the pulmonary circulation. We have been developing the pulmonary circulation assist device for the Fontan circulation using shape memory alloy fibers. The device structure is mechanically contraction from the outside of the extracardiac conduit. For clinical application of the device, we have been also developing the animal experimental model for in vivo examination of the Fontan circulation assist device. In this study, we examined the hemodynamics change in the device driving the animal experimental model. The animal experimental model was constructed in four adult goats (45.8&plusmn;15.6 kg). The right heart bypass of inferior vena cava to pulmonary artery was constructed by using extracardiac conduit, and the left ventricular assist device was connected to reduce of left ventricular load. The device could be mounted easily to the conduit in the thoracic cavity. The pulsatile flow could be generated in the pulmonary circulation by the device contraction. We performed the evaluation of the pediatric pulmonary circulatory assist device in the animal experimental model.

    DOI CiNii

  • Development of behavior measurement apparatus for ePTFE pulmonary valve

    MURA SEITARO, SIRAISHI YASUYUKI, Tuboko Yusuke, Miura Hidekazu, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering   53 ( 0 ) S202_01 - S202_01  2015

     View Summary

    Congenital heart disease as represented by Tetralogy of Fallot (TOF) and Transposition of great arteries may be dysfunction at right heart circulation.Surgical procedure for these cardiac arrest using pulmonary valve made from ePTFE is attracting attention. Clinical result in Japan, surgical procedure using pulmonary valve made from ePTFE is better than using biological valve in terms of thrombus formation and calcification. In order to design this valve, we need know behavior of valve cusp made from ePTFE. This valve is widely applied to clinical site and needed high-performance and high-durability. In this study, we discuss objective assessment for reduce right heart strain by improving pulmonary regurgitation base on high-precision analysis of valve cusp behavior. We manufacture reciprocating motion apparatus for analysis of valve cusp behavior under any flow condition and certain pressure load and studied mechanical characteristic of valve.

    DOI CiNii

  • Design of a detachable swallowing sensor for the artificial esophagus

    TAIRA YASINORI, Watanabe Syota, Homma Dai, Kamiya Kuraudo, Shiraishi Yasuyuki, Miura Hidekazu, Yamada Akihiro, Tsuboko Yusuke, Suzuki Takuji, Hagio Yuki, Mura Seitaro

    Transactions of Japanese Society for Medical and Biological Engineering   53 ( 0 ) S185_01 - S185_01  2015

     View Summary

    There have been demands for improving the level of activity of daily life for the patients with serious esophageal cancer. We have been developing an artificial esophagus by using Ni-Ti shape memory alloy fiber for those patients. The total installation of the device could replay the natural form of food delivery from the mouth to the stomach. In this study, we paused on the interaction control of the deglutition artificial esophagus motion by the natural trigger of the deglutition. Firstly, we made a synchronization system for swallowing required by the sensing of the throat skin acceleration. Then, we examined the sensing activity of swallowing motion detection. We performed an animal experiment to measure the surface motion caused by the deglutition using the accelerometry sensor attached to the goat throat. Secondly, we implemented an additional wireless formation in the sensing system in order to achieve the transcutaneous motion synchronization less invasively. As a result, the system developed in this study exhibited the capability of sensing by the accelerometry of swallowing motion for the sophisticated functional design for a totally implantable artificial esophagus.

    DOI CiNii

  • Improvement of an implantable renal sympathetic cooling device

    SUZUKI TAKUJI, YAMBE TOMOYUKI, SHIRAISHI YASUYUKI, MIURA HIDEKAZU, YAMADA AKIHIRO, TSUBOKO YUSUKE, SANO KYOSUKE, TAIRA YASUNORI

    Transactions of Japanese Society for Medical and Biological Engineering   53 ( 0 ) S267_03 - S267_03  2015

     View Summary

    Peripheral nerves transmission block is an important technique for neurophysiology and biomedical studies. For example, it is known that hypertension is contributed to by enhanced activity of the sympathetic nerve tension based on the generic preposition. Recently, development of renal sympathetic denervation (RSDN) enables us to inhibit renal sympathetic nerve activity (RSNA) by removing renal nerve as hypertensive therapy. The approach using RSDN shows that it is very much therapy, but its long-term safety and effectiveness is still under study. Up to now, we have been working in research and development of a technique that provides a quickly initiated and reversible nerve transmission block. In this study, we developed a prototype renal sympathetic cooling device that can block nerve transmission. This device can be inserted through a catheter and has a structure to be placed around renal nerve. It consists of a Peltier element that cooling area is 2.36 mm &times; 2.38 mm, and a heat sink at heat dissipation surface. For the purpose of its feasibility study, we evaluated the effectiveness of nerves cooling to block nerve transmission without producing nerve &ldquo;onset response&rdquo; firing in animal experiments.

    DOI CiNii

  • ねじれ構造による能動的閉鎖を可能とする形状記憶合金線維を用いた新しい人工食道の開発研究

    平恭紀, 神谷蔵人, 白石泰之, 三浦英和, 志賀卓弥, HASHEM Mohamed, 山田昭博, 坪子侑佑, 佐野恭介, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 本間大, 山家智之

    人工臓器(日本人工臓器学会)   43 ( 2 ) S - 137  2014

    J-GLOBAL

  • 遠心型補助人工心臓を用いた左心補助駆動下の,非接触肺循環血流計測の試み

    渡辺祥太, 白石泰之, 佐野恭介, 廣橋義寛, 三浦英和, ハシム モハメド・オムラン, 山田昭博, 坪子侑佑, 平恭紀, 山家智之, 渡辺祥太, 白石泰之, 佐野恭介, 廣橋義寛, 三浦英和, ハシム モハメド・オムラン, 山田昭博, 坪子侑佑, 平恭紀, 山家智之

    人工臓器(日本人工臓器学会)   43 ( 2 ) S - 152  2014

    J-GLOBAL

  • 遠心ポンプを用いた全置換型人工心臓の駆動部設計

    萩尾勇樹, 萩尾勇樹, 三浦英和, 白石泰之, 志賀卓弥, 山田昭博, 坪子侑佑, HASHEM M・O, 佐野恭介, 平恭紀, 山田昭博, 坪子侑佑, HASHEM M・O, 佐野恭介, 平恭紀, 山家智之

    人工臓器(日本人工臓器学会)   43 ( 2 ) S - 155  2014

    J-GLOBAL

  • 補助循環下におけるハイスピードCCDカメラを用いた腎臓の末梢血管インピーダンス計測

    佐野恭介, 北野智哉, 白石泰之, 三浦英和, ハシム モハメド, 山田昭博, 坪子侑佑, 廣橋義寛, 平恭紀, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 田中明, 吉澤誠, 山家智之

    人工臓器(日本人工臓器学会)   43 ( 2 ) S - 170  2014

    J-GLOBAL

  • 環境温度変化における遠心型補助人工心臓駆動時の心臓血管系の応答解析

    武良盛太郎, 白石泰之, 山田昭博, 三浦英和, ハシム モハメド, 坪子侑佑, 佐野恭介, 平恭紀, 鈴木拓志, 萩尾勇樹, 渡辺祥太, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   43 ( 2 ) S - 171  2014

    J-GLOBAL

  • 形状記憶合金線維を用いた人工心筋アクチュエータのための絶縁コーティングに関する基礎研究

    山田昭博, 白石泰之, 三浦英和, ハシム モハメド, 平恭紀, 坪子侑佑, 佐野恭介, 本間大, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   43 ( 2 ) S - 171  2014

    J-GLOBAL

  • 低圧系循環での人工弁に対するバルサルバ形状がもたらす意義-ex-vivo研究

    松尾諭志, 坪子侑佑, 白石泰之, 高原真吾, 坂爪公, 松村宣寿, 細山勝寛, 正木直樹, 神田桂輔, 片平晋太郎, 鈴木智之, 伊藤校輝, 早津幸弘, 河津聡, 藤原英記, 安達理, 熊谷紀一郎, 川本俊輔, 山家智之, 齋木佳克

    人工臓器(日本人工臓器学会)   43 ( 2 ) S - 185  2014

    J-GLOBAL

  • 定常流型補助人工心臓の圧力流量特性条件が循環に与える影響

    北野智哉, 北野智哉, 佐野恭介, 廣橋義寛, 坪子侑佑, 山田昭博, 三浦英和, 白石泰之, 山家智之

    人工臓器(日本人工臓器学会)   43 ( 2 ) S - 198  2014

    J-GLOBAL

  • Measurement of the pulmonary input impedance for development of a sophisticated pulmonary vascular resistance model

    Tsuboko Yusuke, Shiraishi Yasuyuki, Yamada Akihiro, Shiga Takuya, Sano Kyosuke, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering   52 ( 0 ) O - 315-O-316  2014

     View Summary

    The authors have been developing a pulmonary mechanical circulatory system in order to establish design parameters of newly designed artificial cardiovascular devices. In the quantitative examination of heart valves in pulmonary mock circulation, interactive changes in pressure and flow are regulated by pulmonary impedance characteristics. We focused on the native characteristics changes in impedance in the pulmonary circulation. <BR>To obtain the effect of respiratory control on pulmonary resistance, we measured pulmonary arterial pressure and flow in adult goat under the different respiratory settings with open- and closed-chest condition.<BR>We calculated pulmonary input impedance in two respiratory conditions under the anesthetized open-chest positive pressure ventilation (PPV) and the awake spontaneous respiration (SR). Longitudinal impedance in SR showed lower than in PPV. Characteristic impedance in SR was bigger than in PPV. Therefore, we concluded that the pulmonary impedance should be considered for more sophisticated simulation of pulmonary circulatory support devices.

    DOI CiNii

  • Development of sensorless control system for pediatric pulmonary circulatory assist device using shape memory alloy fibers

    Yamada Akihiro, Shiraishi Yasuyuki, Omran Hashem Mohamed, Miura Hidekazu, Tsuboko Yusuke, Yamagishi Masaaki, Homma Dai, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering   52 ( 0 ) O - 539-O-540  2014

     View Summary

    In order to promote the pulmonary circulation after Fontan procedure, we have been developing a pediatric pulmonary circulatory assist device using shape memory alloy (SMA) fibers. In this study, we developed the sensorless control system for the pulmonary circulatory assist device and examined its fundamental functions. The SMA fiber shows a linear relationship between the internal resistance and longitudinal contraction. We measured a change in current of the fiber during the operation. After driving, the current was 1.8A rises from 1.4A due to contraction of the fiber, and peak value was measured at the complete contraction. We could be achieved monitoring of the contractile condition by the current change. It was indicated the system could be reduce of overheating and decrease in contractile force of the device. In the application of the control method, the high-reliability system as the implantable device might be achieved.

    DOI CiNii

  • Examination of natural esophageal mechanical properties for the design of an artificial esophagus

    Taira Yasunori, Homma Dai, Yambe Tomoyuki, Kamiya Kurodo, Shiraishi Yasuyuki, Miura Hidekazu, Shiga Takuya, Hashem Mohamed, Yamada Akihiro, Tsuboko Yusuke, Sano Kyosuke

    Transactions of Japanese Society for Medical and Biological Engineering   52 ( 0 ) O - 557-O-558  2014

     View Summary

    In order to promote peristaltic function in the patients with the end stage of esophageal cancer, we have been developing an implantable artificial esophagus. Surgical treatments, such as gastroesophagostomy, are applied for alternative reconstruction in the patients, however, the peristaltic motion will be eliminated. In this study, we focused on the distributed function in the native esophagus and examined stress-strain characteristics from proximal to distal portion using freshly extracted goat's esophagus. Prior to the measurement, we developed a new tension test apparatus. As a result, we could evaluate the circumferential esophageal characteristic variations. Then it was suggested that the circumferential stress analysis might be useful for more sophisticated design of artificial esophageal specifications, which would be consistent with the physiological demand as well as the passive structural effects.

    DOI CiNii

  • Design diversity in artificial passive-active circulatory support systems

    Shiraishi Yasuyuki, Morita Kiyozo, Yamagishi Masaaki, Yi Qian, Yambe Tomoyuki, Miura Hidekazu, Tsuboko Yusuke, Yamada Akihiro, Mohamed Hashem Omran, Shiga Takuya, Katahira Shintaro, Akiyama Masatoshi, Saiki Yoshikatsu

    Transactions of Japanese Society for Medical and Biological Engineering   52 ( 0 ) OS - 9-OS-10  2014

     View Summary

    We have been developing several variations of circulatory assist systems based on nano or micro engineering technologies. One of the special features on the design of these new styles of circulatory assist devices will be a passive controllability according to the native signal transmission and hemodynamic response. In this study, we presented the design features and the research diversity for the development of passive-active circulatory support systems, such as artificial myocardial assist devices, circulatory valves, epi-cardial or vascular support systems.

    DOI CiNii

  • Analysis of cardiovascular and autonomic nerve response to visual stress for preclinical medicine

    Miura Hidekazu, Takasaki Eiko, Yamashige Daiki, Taira Yasunori, Yamada Akihiro, Tsuboko Yusuke, Sano Kyosuke, Shiraishi Yasuyuki, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering   52 ( 0 ) SY - 25-SY-26  2014

     View Summary

    Stress is an important factor when we consider responses in the cardiovascular and the autonomic nervous systems. After ethical committee allowance, responses in the cardiovascular system and autonomic nerve were evaluated with the individual characteristics. We investigated relationship between responses to the stress and individual characteristics. Healthy adult participants were assessed with type A scale, Beck depression scale, Hostility scale and Japanese Coronary-prone Behavior Scale (JCBS). Participants were showed hateful images and performed a mathematical task (Sudoku). Heart rate (HR), systolic blood pressure (SBP), LF/HF and pulse wave transmission time (PTT) were measured. The maximum value of the cross-correlation coefficients between BP and HR (&rho;max BH), BP and PTT (&rho;max BT) were analyzed. In both tasks, higher type A scored groups had larger LF/HF, suggesting that the individual characteristics were correlated with the autonomic nervous system. Significant correlation between the Beck depression score and the decrease in PTT and the increase in BP during hateful images were observed. High type A scored or high depression level had the relationship with the stress.

    DOI CiNii

  • 1F17 Preliminary study on the development of an implantable renal nerve cooling device for blood pressure control

    ITO Takuya, MIURA Hidekazu, SHIGA Takuya, MOHAMED Hashem, YAMADA Akihiro, TSUBOKO Yusuke, SHIRAISHI Yasuyuki, KUMAGAI Hiroo, YAMBE Tomoyuki

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   25th ( 0 ) 211 - 212  2013

    DOI CiNii J-GLOBAL

  • 2C02 Improvement of a pulmonary circulatory system for the evaluation of right ventricular outflow tract reconstruction

    TSUBOKO Yusuke, YAMAGISHI Masaaki, YAMBE Tomoyuki, SHIRAISHI Yasuyuki, YAMADA Akihiro, MATSUO Satoshi, SAIKI Yoshikatsu, FENG Zhonggang, AKUTSU Toshinosuke, TANAKA Takashi, Umezu Mitsuo

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   25th ( 0 ) 315 - 316  2013

    DOI CiNii J-GLOBAL

  • 補助人工心臓用経皮的電力伝送システムの高度化に向けた開発研究

    三浦 英和, 山田 昭博, 坪子 侑佑, 伊藤 拓哉, 志賀 卓弥, モハメッド・ハセム・オムラン, 白石 泰之, 山家 智之

    人工臓器   42 ( 1 ) 48 - 49  2013

    CiNii J-GLOBAL

  • Engineering analysis of the effects of bulging sinus in a newly designed paediatric pulmonary heart valve on hemodynamic function

    SUZUKI Ichiro, YABE Shota, MATSUE Ken, SUGAI Telma Keiko, TSUBOKO Yusuke, SAIJO Yoshifumi, YOSHIZAWA Makoto, KAMEYAMA Takeyoshi, SHIRAISHI Yasuyuki, YAMBE Tomoyuki, FENG Zhonggang, OKAMOTO Yoshihiro, TANAKA Takashi, UMEZU Mitsuo, MIYAZAKI Takako, YAMAGISHI Masaaki

      41 ( 1 ) 59 - 61  2012.06

    DOI CiNii J-GLOBAL

  • 血行力学的機能に関する新規設計の小児肺動脈弁のbulging sinusの影響の医工学的分析(Engineering analysis of the effects of bulging sinus in a newly designed paediatric pulmonary heart valve on hemodynamic function)

    鈴木 一郎, 矢部 翔太, 末永 健, Sugai Telma Keiko, 坪子 侑佑, 西條 芳文, 吉澤 誠, 亀山 剛義, 白石 泰之, 山家 智之, 馮 忠剛, 岡本 吉弘, 田中 隆, 梅津 光生, 宮崎 隆子, 山岸 正明

    人工臓器   41 ( 1 ) 59 - 61  2012.06

  • 補助人工心臓用経皮的電力伝送システムの高度化に向けた開発研究

    三浦英和, 山田昭博, 坪子侑祐, 伊藤拓哉, 志賀卓弥, オムラン ハシムモハメッド, 白石泰之, 山家智之, 山家智之, 山家智之

    人工臓器(日本人工臓器学会)   41 ( 2 )  2012

    J-GLOBAL

  • 形状記憶合金を用いた小児用肺循環補助装置における動的駆動制御方法に関する基礎検討

    山田昭博, 白石泰之, 三浦英和, 志賀卓弥, ハセム モハメドオムラン, 神谷蔵人, 坪子侑佑, 森谷葵, 伊藤拓哉, 劉金龍, 銭逸, 山家智之, 山家智之, 山岸正明, 本間大

    人工臓器(日本人工臓器学会)   41 ( 2 ) S - 134  2012

    J-GLOBAL

  • 遠心ポンプ型全置換型人工心臓の右心循環の動物実験モデルにおける右心房収縮のモニタリングの検討

    志賀卓弥, 志賀卓弥, 三浦英和, 伊藤拓哉, 森谷葵, 坪子侑佑, 山田昭博, 神谷蔵人, ハシム モハメド, 白石泰之, 山家智之

    人工臓器(日本人工臓器学会)   41 ( 2 ) S - 155  2012

    J-GLOBAL

  • 心房細動治療のためのPID温度制御法を用いた心房冷却装置開発の基礎検討

    伊藤拓哉, 住吉剛忠, 三浦英和, 神谷蔵人, 志賀卓弥, HASHEM Mohammed, 山田昭博, 坪子侑佑, 森谷葵, 大沢上, 近内利明, 白石泰之, 山家智之

    人工臓器(日本人工臓器学会)   41 ( 2 ) S - 164  2012

    J-GLOBAL

  • 左室乳頭筋モデルによる僧帽弁機能の基礎検討

    橋本尚, 白石泰之, SUGAI Telma Keiko, 志賀卓弥, 古賀千尋, 山田昭博, 坪子侑佑, 三浦英和, 西條芳文, 山家智之, 本間大

    生体医工学   50 ( 4 ) 367 - 367  2012

    J-GLOBAL

  • 小児用肺循環補助装置の駆動方法に関する検討

    山田昭博, 白石泰之, SUGAI Telma Keiko, 三浦英和, 古賀千尋, 橋本尚, 坪子侑佑, 山家智之, 山岸正明, 本間大

    生体医工学   50 ( 4 ) 367 - 367  2012

    J-GLOBAL

  • 新しい小児用肺動脈弁改良設計のための逆解析の試み

    坪子侑佑, 鈴木一郎, SUGAI Telma Keiko, 山田昭博, 北野智哉, 志賀卓弥, 神谷蔵人, 白石泰之, 山家智之, 阿久津敏乃介, 馮忠剛, 梅津光生, 宮崎隆子, 山岸正明

    生体医工学   50 ( 4 ) 370 - 370  2012

    J-GLOBAL

  • 8E12 Parametric estimation of modeling of an ePTFE paediatric pulmonary valve function using transvalvular hemodynamic data

    TSUBOKO Yusuke, SUGAI Telma Keiko

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME   24th (CD-ROM) ( 0 ) _8E12 - 1_-_8E12-2_  2012

    DOI CiNii J-GLOBAL

  • Engineering Analysis of the Effects of Bulging Sinus in a Newly Designed Paediatric Pulmonary Heart Valve on Hemodynamic Function

    鈴木一郎, 鈴木一郎, 矢部翔太, 末永健, SUGAI Telma Keiko, 坪子侑佑, 西條芳文, 吉澤誠, 亀山剛義, 白石泰之, 山家智之, 馮忠剛, 岡本吉弘, 田中隆, 梅津光生, 宮崎隆子, 山岸正明

    東北医学雑誌   124 ( 1 ) 120 - 124  2012  [Invited]

    J-GLOBAL

  • 小児用新型肺動脈人工弁設計における最適化のための新しい設計の基礎検討

    坪子侑佑, 鈴木一郎, 白石泰之, TELMA SUGAI Keiko, 北野智哉, 山田昭博, 志賀卓弥, 神谷蔵人, 劉江箭, 三浦英和, 西條芳文, 山家智之, 松尾諭志, 齋木佳克, 梅津光生, 宮崎隆子, 山岸正明

    人工臓器(日本人工臓器学会)   40 ( 2 )  2011

    J-GLOBAL

  • Preliminary study on the effect of extra-cardiac conduit contractile pressure on the mechanical Fontan circulation support.

    山田昭博, 白石泰之, SUGAI Telma Keiko, 三浦英和, 志賀卓弥, HASHEM Mohamed Omran, 古賀千尋, 橋本尚, 坪子侑佑, 山家智之, 山岸正明, 本間大

    電気学会リニアドライブ研究会資料   LD-11 ( 67-77 ) 41 - 44  2011

    CiNii J-GLOBAL

▼display all

Industrial Property Rights

Awards

  • 若手研究者演題 最優秀賞

    2022.04   人工心臓と補助循環懇話会   拍動循環シミュレータを用いたカテーテル軸流ポンプIMPELLAによる心機能補助性能評価に関する研究

    Winner: 高田淳平, 矢作和之, 坪子侑佑, 岩﨑清隆

  • 第59回日本人工臓器学会大会 大会賞優秀賞

    2021.11   日本人工臓器学会   断層粒子画像流速計測法を用いた大動脈解離モデルにおける解離進展の力学的機序解明に関する基礎検討

    Winner: 坪子侑佑, 伊佐地康佑, 許雪童, 岩﨑清隆

  • 第58回日本人工臓器学会大会 萌芽ポスターセッション優秀賞

    2020.11   日本人工臓器学会   粒子画像流速計測法による弾性左冠動脈前下行枝モデルの血行力学的解析

    Winner: 池原大烈, 坪子侑佑, 新浪博士, 岩﨑清隆

  • 1st Prize, Young Investigator's Award

    2020.05   Japanese Society for Medeical and Biological Engineering   Development of pulsatile circulatory system for measuring ascending aorta hemodynamics with 4D-MRI

    Winner: Natsuki Nakama, Kaoru Hattori, Jumpei Takada, Gohki Nishimura, Ryo Moriwaki, Eita Kawasaki, Michinori Nagao, Yasuhiro Goto, Yusuke Tsuboko, Mitsuo Umezu, Kiyotaka Iwasaki

  • Encouragement award

    2019.06   Japanese Society of Biorheology  

    Winner: Yusuke TSUBOKO

  • IFMBE Asia Pacific Research Networking Fellowship

    2018.06   International Federation of Medical and Biological Engineering   Sophisticated hydrodynamic simulation of pulmonary circulation for the preclinical examination of right heart circulatory assist device

    Winner: Yusuke Tsuboko

  • 第54回日本人工臓器学会大会 萌芽ポスターセッション発表優秀賞

    2016.11   日本人工臓器学会   Fontan循環クリップ開発のための設計構成要素の基礎検討

    Winner: 池田純平, 白石泰之, 坪子侑佑, 平恭紀, 山田昭博, 井上雄介, 山岸正明, 山家智之

  • Young Investigator Poster Award

    2016.11   Japanese Society for Artificial Organs  

  • Young Investigator Poster Award

    2015.11   Japanese Society for Artificial Organs  

    Winner: Yusuke Tsuboko

  • Award

    2011.11   Japanese Society for Artificial Organs   Engineering analysis of the effects of bulging sinus in an newly designed paediatric pulmonary heart valve on hemodynamic function

    Winner: Suzuki I, Shiraishi Y, Yabe S, Tsuboko Y, Sugai TK, Matsue K, Kameyama T, Saijo Y, Tanaka T, Okamoto Y, Feng Z, Miyazaki T, Yamagishi M, Yoshizawa M, Umezu M, Yambe T

▼display all

Research Projects

  • Development of an experimental method for measuring three-dimensional strain distribution in calcified coronary arteries during balloon expansion

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Project Year :

    2021.04
    -
    2024.03
     

    Yusuke Tsuboko, Kiyotaka Iwasaki, Takanobu Yagi, Yutaka Hikichi

  • Subsidy Program for Development of International Standards for Evaluation of Innovative Medical Devices and Regenerative Medicine Products

    Ministry of Health, Labor and Welfare 

    Project Year :

    2020.04
    -
    2023.03
     

    Kiyotaka Iwasaki, Mitsuo Umezu, Yusuke Tsuboko, Yuji Haishima, Atsuko Miyajima, Ryusuke Nakaoka, Yoshihiro Okamoto, Hideyuki Sakoda, Yusuke Nomura

  • Creating a foundation to promote the development of advanced class IV medical devices by the development of human pathological simulator and system (HuPaSS)

    Japan Agency for Medical Research and Development (AMED)  Research on Regulatory Science of Pharmaceuticals and Medical Devices

    Project Year :

    2020
    -
    2023.03
     

    Kiyotaka Iwasaki, Mitsuo Umezu, Hiroshi Kasanuki, Takanobu Yagi, Yusuke Tsuboko

  • Development of visualization method of stent thrmobosis in bifurcated coronary artery

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Project Year :

    2019.04
    -
    2022.03
     

  • Development of a novel arterial lesion vessel model for pulsatile cerebrovascular circulatory simulation

    Institute of Fluid Science, Tohoku University  Collaborative Research Project of the Institute of Fluid Science, Tohoku University

    Project Year :

    2021.04
    -
    2022.03
     

    Yusuke Tsuboko, Yoshihiro Okamoto, Makoto Ohta

  • Development of a method for measuring three-dimensional vascular strain induced by endovascular medical devices

    Waseda Research Institute for Science and Engineering  Encouragement of Scientists

    Project Year :

    2021.04
    -
    2022.03
     

    Yusuke Tsuboko

  • 外科術後のリンパ節検索の適正化を目的とした脂肪除去技術の開発

    公益財団法人テルモ生命科学振興財団  2020年度 研究開発助成

    Project Year :

    2021.01
    -
    2021.12
     

    小島 成浩, 坪子 侑佑, 永井 雄高

  • Development of the small blood circulation simulator to deepen the non-clinical evaluation of medical devices

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Project Year :

    2018.04
    -
    2021.03
     

    Mitsuo Umezu, Yuki Matsuhashi, Kiyotaka Iwasaki, Yusuke TSUBOKO, Takanobu Yagi, Hiroshi Iseki

  • Establishment of a three-dimensional strain measurement method for the quantitative evaluation of transcatheter aortic valve deployment

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Project Year :

    2018.04
    -
    2021.03
     

    Yusuke TSUBOKO

  • Development of a method for measuring three-dimensional vascular strain induced by endovascular medical devices

    Waseda Research Institute for Science and Engineering  Encouragement of Scientists

    Project Year :

    2020.04
    -
    2021.03
     

    Yusuke Tsuboko

  • Development of a method for measuring three-dimensional vascular strain induced by endovascular medical devices

    Waseda Research Institute for Science and Engineering  Encouragement of Scientists

    Project Year :

    2019.04
    -
    2020.03
     

    Yusuke Tsuboko

  • Subsidy Program for Development of International Standards for Evaluation of Innovative Medical Devices and Regenerative Medicine Products

    Ministry of Health, Labour and Welfare 

    Project Year :

    2017.12
    -
    2020.03
     

    Kiyotaka Iwasaki, Mitsuo Umezu, Yusuke Tsuboko, Yuji Haishima, Atsuko Miyajima, Ryusuke Nakaoka, Yoshihiro Okamoto, Hideyuki Sakoda

  • 右心血行動態計測による呼吸性肺血管抵抗変動の力学モデリング

    東北大学加齢医学研究所  東北大学加齢医学研究所共同利用・共同研究

    Project Year :

    2018.04
    -
    2019.03
     

    坪子 侑佑

  • 医工学的方法論による小児用肺動脈弁の設計開発のためのシステム構築

    日本学術振興会  科学研究費助成事業 特別研究員奨励費

    Project Year :

    2015.04
    -
    2017.03
     

    坪子 侑佑

     View Summary

    小児の先天性肺動脈狭窄に対する右室流出路再建に用いられるハンドメイドePTFE製3弁付導管においては、バルサルバ洞形状を模した構造(bulging sinus; BS)を弁基部導管壁に持たせることで、弁開放性能の向上、収縮期エネルギー損失の低減が期待できる。しかしながら、より小児肺循環に適応するためのBS形状について、その改良のための有効な設計指針は明らかになっていない。
    ePTFE製肺動脈弁付導管の形状最適化を目標とし、所有する拍動型小児右心循環シミュレータでの開放性能評価と合わせ、心収縮末期の弁葉閉鎖能に着目した静圧負荷試験による弁性能のトータル評価を実施した。オーバーフロータンクによって弁後流部側から任意の静圧を負荷できる試験装置を構築し、拍動下では観察が困難である導管壁面部の変形を高速度ビデオカメラで詳細に観測し、取得動画に対してOptical flowの手法を用いることで定量的に算出することを試みた。
    研究成果の概要として、構築した試験系によるePTFE弁の弁葉周辺挙動の定量評価が行いえた。導管への圧負荷増加時には弁葉接合部よりリークが生じるが、大型のBSを持たせた導管においては直管型導管や、臨床使用されるBS付ePTFE弁と比してリーク量が増大した。Optical flow解析から、内圧上昇に伴い導管壁面のBS縫合部の径方向への拡張が観測され、弁尖接合部の間隙が大きくなることでリークが増大することが示された。これまでに実施された模擬循環回路や動物実験結果からはBSの大型化による拍動下での弁葉開放挙動の促進効果が示されているが、今後、閉鎖時の導管変形および閉鎖時リークとのトレードオフを考慮することで、弁葉およびBS形状といった設計指標の相互作用を定量的に示しえる可能性が示された。

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Presentations

  • 非臨床実験モデルを用いた補助循環治療の検討と臨床への応用

    矢作和之, 坪子侑佑, 岩﨑清隆  [Invited]

    第50回人工心臓と補助循環懇話会学術集会  (長野)  人工心臓と補助循環懇話会

    Presentation date: 2022.04

    Event date:
    2022.04
     
     
  • 非臨床評価技術による人工心臓の開発促進

    坪子侑佑, 岩﨑清隆  [Invited]

    第50回人工心臓と補助循環懇話会学術集会 

    Presentation date: 2022.04

    Event date:
    2022.04
     
     
  • 血管内補助循環デバイスの治療効果を可視化する粒子画像流速計測評価系の開発

    許雪童, 坪子侑佑, 伊佐地康佑, 倉本慧, 岩﨑清隆

    第50回人工心臓と補助循環懇話会学術集会  (長野)  人工心臓と補助循環懇話会

    Presentation date: 2022.04

    Event date:
    2022.04
     
     
  • 拍動循環シミュレータを用いたカテーテル軸流ポンプIMPELLA による心機能補助性能評価に関する研究

    高田淳平, 矢作和之, 坪子侑佑, 岩﨑清隆

    第50回人工心臓と補助循環懇話会学術集会  (長野)  人工心臓と補助循環懇話会

    Presentation date: 2022.04

    Event date:
    2022.04
     
     
  • ImpellaとVA-ECMO併用時の血行動態

    矢作和之, 坪子侑佑, 岩﨑清隆

    第86回日本循環器学会学術集会  日本循環器学会

    Presentation date: 2022.03

    Event date:
    2022.03
     
     
  • -

    Yusuke Tsuboko  [Invited]

    86th Annual Scientific Meeting of the Japanese Circulation Society  The Japanese Circulation Society

    Presentation date: 2022.03

    Event date:
    2022.03
     
     
  • Development of a Novel Arterial Lesion Vessel Model for Pulsatile Cerebrovascular Circulatory Simulation

    Yusuke Tsuboko, Yoshihiro Okamoto, Makoto Ohta

    18th International Conference on Flow Dynamics  (Sendai) 

    Presentation date: 2021.10

    Event date:
    2021.10
     
     
  • Development of Three-Dimensional Strain Measurement Method for Coronary Artery Model Using Tomographic Particle Image Velocimetry

    Yusuke Tsuboko Xuetong, Xu Kousuke, Isaji Kiyotaka Iwasaki

    Presentation date: 2021.09

    Event date:
    2021.09
     
     
  • 粒子画像流速計測法による冠動脈バイパス術後の左冠動脈前下行枝内流れの評価可能な実験系の構築

    池原大烈, 坪子侑佑, 新浪博士, 岩﨑清隆

    第26回日本Advanced Heart & Vascular Surgery/OPCAB研究会 

    Presentation date: 2021.07

    Event date:
    2021.07
     
     
  • 拍動循環装置を用いた経カテーテル弁の弁葉とステントフレーム間の流れの可視化

    許雪童, 藍龍之介, 前原瑠海, 坪子侑佑, 岩﨑清隆

    日本機械学会 第33回バイオエンジニアリング講演会 

    Presentation date: 2021.06

    Event date:
    2021.06
     
     
  • IMPELLA による心負荷軽減の実験的評価のための拍動循環シミュレータの開発

    坪子侑佑, 西村剛毅, 矢作和之, 岩﨑清隆

    第49回人工心臓と補助循環懇話会学術集会 

    Presentation date: 2021.02

    Event date:
    2021.02
     
     
  • カテーテルデバイス開発促進のための非臨床研究

    坪子侑佑, 岩﨑清隆

    第58回日本人工臓器学会大会 

    Presentation date: 2020.11

    Event date:
    2020.11
     
     
  • Investigation of Pressure Reduction Due to Thrombus Formation Inside the False Lumen of Chronic Aortic Dissection Models under a Pulsatile Circulation

    Naoki Yomoda, Kazuma Nakamura, Kota Shukuzawa, Yusuke Tsuboko, Mitsuo Umezu, Kiyotaka Iwasaki

    42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society 

    Presentation date: 2020.07

    Event date:
    2020.07
     
     
  • 腹部大動脈用ステントグラフトの不具合報告情報を用いたファンネルプロットによる可視化と詳細分析の試み

    坪子侑佑, 松橋祐輝, 宿澤孝太, 笠貫宏, 岩﨑清隆

    第57回日本人工臓器学会大会 

    Presentation date: 2019.11

    Event date:
    2019.11
     
     
  • 経カテーテル大動脈弁における弁葉周辺および冠動脈開口部流れの可視化のための拍動循環シミュレータ開発

    坪子侑佑, 藍龍之介, 前原瑠海, 許雪童, 岩﨑清隆

    第42回日本バイオレオロジー学会年会 

    Presentation date: 2019.06

    Event date:
    2019.06
     
     
  • Pre-Clinical Testing Platform for the Functional Evaluation of Right Heart Circulatory Assist Device

    Yusuke TSUBOKO  [Invited]

    IFMBE 2018 Asia Pacific Young Researcher Workshop  (Tshinghua University, Beijing, China) 

    Presentation date: 2018.05

  • 先天性心不全に対する新規Fontan clipの試験のための模擬肺循環システム(Mock pulmonary circulatory system for the examination of a new Fontan clip for congenial heart failure)

    軽部 雅人, 白石 泰之, 山田 昭博, 坪子 侑佑, 中畑 碧, 山家 智之

    人工臓器 

    Presentation date: 2017.08

  • Fontan循環クリップ開発のための設計構成要素の基礎検討

    池田純平, 白石泰之, 坪子侑佑, 平恭紀, 山田昭博, 井上雄介, 山岸正明, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2017.06

  • 食物運搬機能を有する人工食道ステント開発のための非線形粘弾性モデルを用いた生体力学的特性解析

    平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, FENG Zhonggang, 山家智之, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2017.06

  • Analysis of swallowing motion by using non-contact 3-D skin deglutition measurement

    Taira Yasunori, Shiraishi Yasuyuki, Inoue Yusuke, Yamada Akihiro, Tsuboko Yusuke, Arakawa Tomoya, Yuba Mitsuru

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2017

     View Summary

    Evaluation of swallowing motion is necessary for preventing aspiration pneumonia. MRI and sound analyses are recent deglutition diagnoses, however, these are inherently susceptible to noise. We focused on the detection of skin motion around pharyngeal portion, and examined the feasibility of information measured by a depth camera. Firstly, we measured the pharyngeal portion in healthy subjects during the process of drinking water or saline. Secondly, we measured the pharyngeal skin during eating process of a piece of bread pasted with oil or with high viscosity gelatin. Results were as follows: a) we obtained the prospective self-gating of swallowing using depth information, b) the measurement is available for frequency analysis of the gating, and c) the deglutition was associated with the taste with respect to the sensory inspection. Consequently, periodical measurements by the 3-D depth camera might be useful for the selection of profiles corresponding to food intake including individual preferences.

  • Development of Valve Test System for Evaluating the Pulmonary Trileaflet Motion

    Tsuboko Yusuke, Shiraishi Yasuyuki, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2017

     View Summary

    An expanded polytetrafluoroethylene (ePTFE) pulmonary conduit valve is commonly used for the pulmonary valve reconstruction in patients with congenital heart failure. The special features of the valve are fan-shaped leaflets and the bulging sinus which is representing the Valsalva shape. The purpose of this study was to compare valvular motion in the newly designed pulmonary valve tester.To investigate valvular function under the low-pressure pulmonary hemodynamic condition, we used two different types of ePTFE leaflets and examined their characteristics by using a high-speed camera. Each 0.1 mm-thick leaflet with different cusp depth was installed in the conduit valve holder. The holder was connected to a linear actuator. We compared the relationships between leaflet motion and annular displacement.We could achieve the comparison of leaflet motion with different cusp, and it was suggested that the cusp depth might be an important parameter to optimize the coaptation zone in ePTFE pulmonary valves.

  • Improvement of the implantable renal nerve cooling device and examine the effect of cooling for nerve activity

    Yuba Mitsuru, Nakagata Hiroshi, Shiraishi Yasuyuki, Inoue Yusuke, Yamada Akihiro, Tsuboko Yusuke, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2017

     View Summary

    The purpose of this study was to improve an implantable renal nerve cooling device which was capable of regulating the surface temperature of the renal nerve in hypertensive patients. We used a Peltier elements and performed a component design combined with a heat pipe for the implantable device as a proof of concept. The implantable device was composed two components: a) a Peltier element having 3.94 mm thickness with a rectangular cooling plate of 3.2 mm x 3.2 mm, b) a heat pipe having 6 mm diameter with 250 mm length, which was to be mechanically and thermally connected to the radiation surface of the Peltier element. We examined the surface cooling effects by a thermal camera against the several power supply conditions for the Peltier element. As a result, the cooling surface showed the controllable temperature by the electric power supply with the heat-pipe unit without any radiation fluids.

  • 食感特性評価のための嚥下挙動解析

    平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 山家智之

    日本統合医療学会誌 

    Presentation date: 2016.12

  • 生体内組織の局所温度調節による血圧制御の医工学的基礎検討

    弓場充, 中潟寛, 白石泰之, 山田昭博, 井上雄介, 坪子侑佑, 平恭紀, 池田純平, 荒川友哉, 山家智之

    日本統合医療学会誌 

    Presentation date: 2016.12

  • 左心循環補助時における心房細動が脈診計測へ及ぼす影響の基礎検討

    小林由佳, 齋藤大, 渡邉健太郎, 白石泰之, 坪子侑佑, 弓場充, 山田昭博, 井上雄介, 平恭紀, 池田純平, 荒川友哉, 山家智之

    日本統合医療学会誌 

    Presentation date: 2016.12

  • 東洋医学における脈診計測評価のための模擬循環回路の開発

    齋藤大, 小林由佳, 渡邉健太郎, 坪子侑佑, 白石泰之, 荒川友哉, 山田昭博, 井上雄介, 平恭紀, 池田純平, 弓場充, 山家智之

    日本統合医療学会誌 

    Presentation date: 2016.12

  • 補助人工心臓のポンプ性能差異による末梢脈波変化についての考察

    渡邉健太郎, 齋藤大, 小林由佳, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 平恭紀, 池田純平, 荒川友哉, 弓場充, 山家智之

    日本統合医療学会誌 

    Presentation date: 2016.12

  • 非臨床試験および前臨床試験手法を用いた心臓血管系診断に対する科学的アプローチ

    井上雄介, 白石泰之, 山田昭博, 坪子侑佑, 平恭紀, 池田純平, 荒川友哉, 弓場充, 山家智之, 山家智之

    日本統合医療学会誌 

    Presentation date: 2016.12

  • 脈波診断に医工学的根拠を付与する定量的評価手法の開発

    山田昭博, 坪子侑佑, 井上雄介, 平恭紀, 白石泰之, 関隆志, 山家智之

    日本統合医療学会誌 

    Presentation date: 2016.12

  • 動脈系末梢部の医工学的モデリングによる血圧血流応答

    坪子侑佑, 白石泰之, 山家智之

    日本統合医療学会誌 

    Presentation date: 2016.12

  • 皮膚組織を貫通する人工物の癒着強度評価試験のための基礎検討

    弓場充, 坪子侑佑, 白石泰之, 井上雄介, 平恭紀, 太田信, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2016.10

  • 電力制御によるFontan循環補助装置のための収縮制御モニタリングシステムの構築

    山田昭博, 三浦英和, 白石泰之, 坪子侑佑, 坪子侑佑, 平恭紀, 池田純平, 本間大, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2016.10

  • 食物運搬機能を有する人工食道ステント開発のための非線形粘弾性モデルを用いた生体力学的特性解析

    平恭紀, 白石泰之, 井上雄介, 山田昭博, 坪子侑佑, 池田純平, 荒川友哉, 弓場充, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2016.10

  • 小児用ePTFE製肺動脈弁付導管の形状改良のための静圧負荷逆流特性計測

    坪子侑佑, 坪子侑佑, 白石泰之, 山田昭博, 平恭紀, 平恭紀, 池田純平, 山岸正明, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2016.10

  • Fontan循環クリップ開発のための設計構成要素の基礎検討

    池田純平, 白石泰之, 坪子侑佑, 平恭紀, 山田昭博, 井上雄介, 山岸正明, 山家智之, 本間大

    人工臓器(日本人工臓器学会) 

    Presentation date: 2016.10

  • ステントグラフト内挿術における血流変動時の後負荷評価のための循環シミュレーションによる基礎検討

    荒川友哉, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 佐々木一益, 平恭紀, 池田純平, 高野智弘, 高野真澄, 横山斉, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2016.10

  • 血管ステント治療における心機能の後負荷評価モデル構築の試み

    荒川友哉, 白石泰之, 坪子侑佑, 山田昭博, 井上雄介, 平恭紀, 佐々木一益, 渡辺祥太, 池田純平, 弓場充, 山家智之, 高野智弘, 高野真澄, 横山斉

    LIFE講演概要集(CD-ROM) 

    Presentation date: 2016.09

  • 高精度な血液循環模擬による右心循環補助デバイスの医工学評価

    坪子侑佑, 白石泰之, 山田昭博, 平恭紀, 井上雄介, 佐々木一益, 渡辺祥太, 池田純平, 荒川友哉, 弓場充, 山家智之

    LIFE講演概要集(CD-ROM) 

    Presentation date: 2016.09

  • 医療用ハイブリッド材料の滅菌に関する研究

    井上雄介, 田代彩夏, 磯山隆, 斎藤逸郎, 阿部裕輔, 白石泰之, 山田昭博, 坪子侑佑, 原伸太郎, 圦本晃海, 三浦英和, 山家智之

    LIFE講演概要集(CD-ROM) 

    Presentation date: 2016.09

  • 高血圧治療を目的とした埋込型腎神経冷却デバイスの改良

    弓場充, 白石泰之, 中潟寛, 山田昭博, 坪子侑佑, 井上雄介, 佐々木一益, 平恭紀, 渡辺祥太, 池田純平, 荒川友哉, 山家智之

    LIFE講演概要集(CD-ROM) 

    Presentation date: 2016.09

  • 小児用ePTFE製肺動脈弁の弁葉およびbulging sinusが弁機能へ及ぼす影響の基礎検討

    坪子侑佑, 武良盛太郎, 白石泰之, 山田昭博, 山岸正明, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2016.06

  • ePTFE製肺動脈弁の弁挙動解析の基礎検討

    武良盛太郎, 坪子侑佑, 白石泰之, 三浦英和, 山岸正明, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2016.06

  • Thermodynamic Effect on Fontan Circulation Assist Device

    YAMADA Akihiro, SHIRAISHI Yasuyuki, MIURA Hidekazu, TSUBOKO Yusuke, TAIRA Yasunori, INOUE Yusuke, HOMMA Dai, YAMAGISHI Masaaki, YAMBE Tomoyuki

    Proceedings. International Conference on Flow Dynamics (CD-ROM) 

    Presentation date: 2016

  • Implantable Renal Nerve Heat Control Device for Pressure Regulation in Hypertension

    SHIRAISHI Yasuyuki, NAKAGATA Hiroshi, YUBA Mitsuru, SUZUKI Takuji, TSUBOKO Yusuke, YAMADA Akihiro, INOUE Yusuke, SASAKI Kazumasu, KUMAGAI Hiroo, YAMBE Tomoyuki

    Proceedings. International Conference on Flow Dynamics (CD-ROM) 

    Presentation date: 2016

  • Biomechanical characteristic analysis of natural esophageal using a non-liner viscoeolastic model

    Taira Yasunori, Shiraishi Yasuyuki, Miura Hidekazu, Inoue Yusuke, Sasaki Kazumasu, Yamada Akihiro, Tsuboko Yusuke, Suzuki Takuji, Hagio Yuki, Mura Seitaro, Ikeda Jumpei, Homma Dai, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2016

  • Newly development of implantable Fontan circulation assist device

    Yamada Akihiro, Shiraishi Yasuyuki, Miura Hidekazu, Taira Yasunori, Tsuboko Yusuke, Ikeda Jyunpei, Inoue Yusuke, Yamagishi Masaaki, Homma Dai, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2016

     View Summary

    現在我々は、小児先天性心疾患患者のFontan循環を補助する体内埋込み型肺循環補助装置の開発を進めている。形状記憶合金(SMA)繊維をアクチュエータとして応用し、Fontan循環での心外導管外周部に巻き付け、外部から拍動収縮する構造である。これまでに、生体での評価試験系構築のために健常成山羊を用いたFontan循環動物実験モデルを構築した。本研究では、生体内でも有効に収縮駆動可能なデバイスの構造を設計試作し、駆動試験を行い収縮特性と有用性の評価を行った。アクチュエータとして用いるSMAファイバは、通電加熱により約5-7%収縮する特性を持つ。収縮量を増幅するために、有効な拍動を行う部位と収縮量を得るスリーブ部の構成とした。滑り性が高く耐熱性のあるPTFEチューブにSMAファイバを通すことで、収縮を阻害しにくくした。スリーブ部には、ガラスファイバー製のスリーブを用い、長軸方向に収縮しにくい構造とし、拍動部にはシリコーンチューブを使用し有効な収縮と絶縁性を有する構造とした。試作したデバイスを用いて収縮駆動試験を行った。電極接続部には、シリコーン樹脂で包埋し、絶縁性を持たせた。体内埋め込み時の収縮特性試験の結果、長軸方向に巻き付け部の25%に相当する有効な収縮を得ることができた。また、Fontan循環動物モデルで小児用肺循環補助デバイスの駆動試験を実施し、体内埋め込み時にもデバイス付与によるFontan循環補助の可能性が示唆された。

  • Hemodynamic examination for shape optimization of ePTFE valved conduit with bulging sinuses

    Tsuboko Yusuke, Shiraishi Yasuyuki, Miura Hidekazu, Inoue Yusuke, Yamada Akihiro, Taira Yasunori, Ikeda Jumpei, Yamagishi Masaaki, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2016

  • Design and evaluation of a newly developed Fontan clip

    Ikeda Jumpei, Shiraishi Yasuyuki, Yamada Akihiro, Tsuboko Yusuke, Taira Yasunori, Suzuki Takuji, Inoue Yusuke, Homma Dai, Yamagishi Masaaki, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2016

  • 食物運搬機能を有する人工食道のための嚥下検知システムの設計開発

    平恭紀, 白石泰之, 三浦英和, 井上雄介, 佐々木一益, 山田昭博, 山田昭博, 坪子侑佑, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 本間大, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2015.10

  • 小児用ePTFE製肺動脈弁の弁葉およびbulging sinusが弁機能へ及ぼす影響の基礎検討

    坪子侑佑, 白石泰之, 武良盛太郎, 山田昭博, 山岸正明, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2015.10

  • 右心循環用に用いる人工心臓用モータの性能評価

    萩尾勇樹, 三浦英和, 白石泰之, 片平晋太郎, 佐々木一益, 山田昭博, 坪子侑佑, 平恭紀, 平恭紀, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2015.10

  • CCDを用いた埋め込み型小型肺循環血流観察デバイス開発のための基礎検討

    渡辺祥太, 白石泰之, 三浦英和, 井上雄介, 坪子侑佑, 平恭紀, 山家智之, 渡辺祥太, 白石泰之, 三浦英和, 井上雄介, 山田昭博, 坪子侑佑, 平恭紀, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2015.10

  • ePTFE製肺動脈弁の弁挙動解析の基礎検討

    武良盛太郎, 白石泰之, 坪子侑佑, 三浦英和, 山岸正明, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2015.10

  • 本態性高血圧治療を目的とした腎神経活動制御のための埋め込み型腎神経冷却装置の基礎検討

    鈴木拓志, 白石泰之, 三浦英和, 山田昭博, 坪子侑佑, 平恭紀, 井上雄介, 山家智之, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2015.10

  • 右心バイパス血流路を有する動物実験モデルによる小児用肺循環補助装置の血行動態評価

    山田昭博, 山田昭博, 白石泰之, 三浦英和, 坪子侑佑, 坪子侑佑, 平恭紀, 井上雄介, 山岸正明, 本間大, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2015.10

  • 環境温度変化における遠心型補助人工心臓駆動時の心臓血管系の応答解析

    武良盛太郎, 白石泰之, 山田昭博, 三浦英和, 坪子侑佑, 佐野恭介, 平恭紀, 鈴木拓志, 萩尾勇樹, 渡辺祥太, 山家智之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2015.06

  • Design of a detachable swallowing sensor for the artificial esophagus

    TAIRA YASINORI, Kamiya Kuraudo, Shiraishi Yasuyuki, Miura Hidekazu, Yamada Akihiro, Tsuboko Yusuke, Suzuki Takuji, Hagio Yuki, Mura Seitaro, Watanabe Syota, Homma Dai

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2015

     View Summary

    There have been demands for improving the level of activity of daily life for the patients with serious esophageal cancer. We have been developing an artificial esophagus by using Ni-Ti shape memory alloy fiber for those patients. The total installation of the device could replay the natural form of food delivery from the mouth to the stomach. In this study, we paused on the interaction control of the deglutition artificial esophagus motion by the natural trigger of the deglutition. Firstly, we made a synchronization system for swallowing required by the sensing of the throat skin acceleration. Then, we examined the sensing activity of swallowing motion detection. We performed an animal experiment to measure the surface motion caused by the deglutition using the accelerometry sensor attached to the goat throat. Secondly, we implemented an additional wireless formation in the sensing system in order to achieve the transcutaneous motion synchronization less invasively. As a result, the system developed in this study exhibited the capability of sensing by the accelerometry of swallowing motion for the sophisticated functional design for a totally implantable artificial esophagus.

  • Improvement of an implantable renal sympathetic cooling device

    SUZUKI TAKUJI, YAMBE TOMOYUKI, SHIRAISHI YASUYUKI, MIURA HIDEKAZU, YAMADA AKIHIRO, TSUBOKO YUSUKE, SANO KYOSUKE, TAIRA YASUNORI

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2015

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    Peripheral nerves transmission block is an important technique for neurophysiology and biomedical studies. For example, it is known that hypertension is contributed to by enhanced activity of the sympathetic nerve tension based on the generic preposition. Recently, development of renal sympathetic denervation (RSDN) enables us to inhibit renal sympathetic nerve activity (RSNA) by removing renal nerve as hypertensive therapy. The approach using RSDN shows that it is very much therapy, but its long-term safety and effectiveness is still under study. Up to now, we have been working in research and development of a technique that provides a quickly initiated and reversible nerve transmission block. In this study, we developed a prototype renal sympathetic cooling device that can block nerve transmission. This device can be inserted through a catheter and has a structure to be placed around renal nerve. It consists of a Peltier element that cooling area is 2.36 mm × 2.38 mm, and a heat sink at heat dissipation surface. For the purpose of its feasibility study, we evaluated the effectiveness of nerves cooling to block nerve transmission without producing nerve "onset response" firing in animal experiments.

  • Examination of pediatric pulmonary circulation assist device based on Fontan circulation animal experimental model

    YAMADA AKIHIRO, Shiraisihi Yasuyuki, Miura Hidekazu, Tsuboko Yusuke, Taira Yasunori, Sano Kyosuke, Yamagishi Masaaki, Homma Dai, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2015

     View Summary

    Fontan procedure is the final palliative surgical operation in pediatric patients with congenital heart disease. After Fontan procedure, there is non-pulsatile flow in the pulmonary circulation. We have been developing the pulmonary circulation assist device for the Fontan circulation using shape memory alloy fibers. The device structure is mechanically contraction from the outside of the extracardiac conduit. For clinical application of the device, we have been also developing the animal experimental model for in vivo examination of the Fontan circulation assist device. In this study, we examined the hemodynamics change in the device driving the animal experimental model. The animal experimental model was constructed in four adult goats (45.8±15.6 kg). The right heart bypass of inferior vena cava to pulmonary artery was constructed by using extracardiac conduit, and the left ventricular assist device was connected to reduce of left ventricular load. The device could be mounted easily to the conduit in the thoracic cavity. The pulsatile flow could be generated in the pulmonary circulation by the device contraction. We performed the evaluation of the pediatric pulmonary circulatory assist device in the animal experimental model.

  • Development of behavior measurement apparatus for ePTFE pulmonary valve

    MURA SEITARO, SIRAISHI YASUYUKI, Tuboko Yusuke, Miura Hidekazu, Yambe Tomoyuki

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2015

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    Congenital heart disease as represented by Tetralogy of Fallot (TOF) and Transposition of great arteries may be dysfunction at right heart circulation.Surgical procedure for these cardiac arrest using pulmonary valve made from ePTFE is attracting attention. Clinical result in Japan, surgical procedure using pulmonary valve made from ePTFE is better than using biological valve in terms of thrombus formation and calcification. In order to design this valve, we need know behavior of valve cusp made from ePTFE. This valve is widely applied to clinical site and needed high-performance and high-durability. In this study, we discuss objective assessment for reduce right heart strain by improving pulmonary regurgitation base on high-precision analysis of valve cusp behavior. We manufacture reciprocating motion apparatus for analysis of valve cusp behavior under any flow condition and certain pressure load and studied mechanical characteristic of valve.

  • Preliminary study for the development of a sophisticated pulmonary vascular resistance model

    TSUBOKO YUSUKE, WATANABE SYOTA, SHIRAISHI YASUYUKI, MIURA HIDEKAZU, YAMADA AKIHIRO, SUZUKI TAKUJI, TAIRA YASUNORI, YAMBE TOMOYUKI

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2015

     View Summary

    The authors have been developing a pulmonary mechanical simulator in order to establish a design parameters of a novel artificial cardiovascular devices. In pulmonary circulation, interactive pressure-flow changes are regulated by pulmonary impedance characteristics. We focused on the native impedance characteristics variation in the pulmonary circulation. To examine the effect of respiratory control on pulmonary resistance, we measured pulmonary arterial pressure and flow in adult goat under the different respiratory settings with open/closed-chest condition. Pulmonary input impedance in two respiratory conditions under the anesthetized open-chest positive pressure ventilation (PPV) and the awake spontaneous respiration (SR) were calculated. Longitudinal impedance at 0 Hz in SR showed lower than in PPV, and at high harmonic area in SR was bigger than in PPV. In order to examine the hemodynamic response for newly designed artificial internal organs, pulmonary impedance variation caused by respiratory control should be considered. For sophisticated pulmonary resistance model, reproducing the negative pressure condition in the thoracic cavity, and pulmonic vascular resistance regulation might be required.

  • The evaluation of motor characteristics of the total artificial heart by the change in the rotor to stator gap

    HAGIO YUUKI, MIURA HIDEKAZU, SHIRAISHI YASUYUKI, SHIGA TAKUYA, YAMADA AKIHIRO, TSUBOKO YUSUKE, SANO KYOSUKE, TAIRA YASUNORI, YAMBE TOMOYUKI

    Transactions of Japanese Society for Medical and Biological Engineering 

    Presentation date: 2015

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    In the development of total artificial heart (TAH), we must design left and right pumps separately to achieve a proper flow balance. In this study, we designed a motor of pump to maintain right heat circulation and prototyped. The Motor was designed by using Assumptive Magnetic Flux Path Method. We made equivalent circuit by this method, and evaluated synthetic reluctance, magnetic flux of gap for the purpose of inhibiting magnetic saturation. We adopted structure of DC brushless, four poles and 12 slots. We assumed the pump efficiency was 50%.We set maximum amount of cardiac output was 10L/min, maximum pressure was 20mmHg when rotation number was 3000rpm.In measurement, we examined the effect of gap difference, we changed the gap was 1.0 mm and 1.5 mm respectively. Result of measurement, torque and speed constants was 55 mNm/A and 180 rpm/V, 51 mNm/A and 198 rpm/V when the gap difference was 1.0 mm and 1.5 mm respectively. We confirmed the characteristics of the motor tend to high torque when the gap is narrow. On the other hand, it tends to high revolution when the gap is wide.

  • 形状記憶合金線維を用いた人工心筋アクチュエータのための絶縁コーティングに関する基礎研究

    山田昭博, 白石泰之, 三浦英和, ハシム モハメド, 平恭紀, 坪子侑佑, 佐野恭介, 本間大, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • 遠心ポンプを用いた全置換型人工心臓の駆動部設計

    萩尾勇樹, 三浦英和, 白石泰之, 志賀卓弥, 山田昭博, 坪子侑佑, HASHEM M・O, 佐野恭介, 平恭紀, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • 環境温度変化における遠心型補助人工心臓駆動時の心臓血管系の応答解析

    武良盛太郎, 白石泰之, 山田昭博, 三浦英和, ハシム モハメド, 坪子侑佑, 佐野恭介, 平恭紀, 鈴木拓志, 萩尾勇樹, 渡辺祥太, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • 低圧系循環での人工弁に対するバルサルバ形状がもたらす意義―ex‐vivo研究

    松尾諭志, 坪子侑佑, 白石泰之, 高原真吾, 坂爪公, 松村宣寿, 細山勝寛, 正木直樹, 神田桂輔, 片平晋太郎, 鈴木智之, 伊藤校輝, 早津幸弘, 河津聡, 藤原英記, 安達理, 熊谷紀一郎, 川本俊輔, 山家智之, 齋木佳克

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • 高速動画撮影による右心系模擬循環での人工弁の挙動解析

    坪子侑佑, 松尾諭志, 白石泰之, 山田昭博, 三浦英和, 平恭紀, 佐野恭介, 武良盛太郎, 齋木佳克, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • 遠心型補助人工心臓を用いた左心補助駆動下の,非接触肺循環血流計測の試み

    渡辺祥太, 白石泰之, 佐野恭介, 廣橋義寛, 三浦英和, ハシム モハメド・オムラン, 山田昭博, 坪子侑佑, 平恭紀, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • ねじれ構造による能動的閉鎖を可能とする形状記憶合金線維を用いた新しい人工食道の開発研究

    平恭紀, 神谷蔵人, 白石泰之, 三浦英和, 志賀卓弥, HASHEM Mohamed, 山田昭博, 坪子侑佑, 佐野恭介, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 本間大, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • 定常流型補助人工心臓の圧力流量特性条件が循環に与える影響

    北野智哉, 佐野恭介, 廣橋義寛, 坪子侑佑, 山田昭博, 三浦英和, 白石泰之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • 補助循環下におけるハイスピードCCDカメラを用いた腎臓の末梢血管インピーダンス計測

    佐野恭介, 北野智哉, 白石泰之, 三浦英和, ハシム モハメド, 山田昭博, 坪子侑佑, 廣橋義寛, 平恭紀, 鈴木拓志, 萩尾勇樹, 武良盛太郎, 渡辺祥太, 田中明, 吉澤誠, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • 小型化した遠心型補助人工心臓EVAHEARTの慢性動物実験の血液動態の評価

    三浦英和, 山重大樹, 高崎映子, 白石泰之, 平恭紀, 坪子侑佑, 山田昭博, 山崎健二, 西中知博, 山田有希子, 片平晋太郎, 秋山正年, 齋木佳克, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • Hemodynamic assessment of an implantable shape memory alloy fibered aortic cardiovascular assist device in animal model

    HASHEM Mohamed, SHIRAISHI Yasuyuki, YAMADA Akihiro, TSUBOKO Yusuke, MIURA Hidekazu, TAIRA Yasunori, SANO Kyosuke, YAMABE Tomoyuki, HOMMA Dai

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.09

  • Functional improvement of a newly developed extra aortic counter-pulsation device using shape memory alloy fibers

    HASHEM Mohamed Omran, SHIRAISHI Yasuyuki, YAMADA Akihiro, TSUBOKO Yusuke, MIURA Hidekazu, YAMBE Tomoyuki

    人工臓器(日本人工臓器学会) 

    Presentation date: 2014.06

  • EPTFE Valve Dynamics in the Pulmonary Mock Circulatory System

    SHIRAISHI Yasuyuki, TSUBOKO Yusuke, SUZUKI Ichiro, MATSUO Satoshi, SAIKI Yoshikatsu, YAMBE Tomoyuki, YAMAGISHI Masaaki, QIAN Yi

    Proc Int Conf Flow Dyn (CD-ROM) 

    Presentation date: 2014

  • Examination of natural esophageal mechanical properties for the design of an artificial esophagus

    TAIRA Yasunori, KAMIYA Kurodo, SHIRAISHI Yasuyuki, MIURA Hidekazu, HASHEM Mohamed Omran, YAMADA Akihiro, TSUBOKO Yusuke, SANO Kyosuke, HOMMA Dai, YAMMBE Tomoyuki

    日本生体医工学会大会プログラム・論文集(CD-ROM) 

    Presentation date: 2014.01

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved.In order to promote peristaltic function in the patients with the end stage of esophageal cancer, we have been developing an implantable artificial esophagus. Surgical treatments, such as gastroesophagostomy, are applied for alternative reconstruction in the patients, however, the peristaltic motion will be eliminated. In this study, we focused on the distributed function in the native esophagus and examined stress-strain characteristics from proximal to distal portion using freshly extracted goat’s esophagus. Prior to the measurement, we developed a new tension test apparatus. As a result, we could evaluate the circumferential esophageal characteristic variations. Then it was suggested that the circumferential stress analysis might be useful for more sophisticated design of artificial esophageal specifications, which would be consistent with the physiological demand as well as the passive structural effects.

  • Development of sensorless control system for pediatric pulmonary circulatory assist device using shape memory alloy fibers

    YAMADA Akihiro, SHIRAISHI Yasuyuki, HASHEM Mohamed Omran, MIURA Hidekazu, TSUBOKO Yusuke, YAMBE Tomoyuki, HOMMA Dai, YAMAGISHI Masaaki

    日本生体医工学会大会プログラム・論文集(CD-ROM) 

    Presentation date: 2014.01

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved.In order to promote the pulmonary circulation after Fontan operation, we developed a pediatric pulmonary circulatory assist device using shape memory alloy fibers. In this study, we developed the sensor-less control system for the pulmonary circulatory assist device and examined its fundamental functions. The SMA fiber showed a linear relationship between the internal resistance and longitudinal contraction. We measured the change in current of the fiber during the operation. Electric current increased from 1.4 to 1.8 A during operation, and the maximum current supply was measured at the end of the contraction. Therefore, we could be estimated the device contraction by the measurement of current which was calculated by voltage sampling of fiber units. Prevention of the overheating of the fiber unit was one of the problem throughout the operation of the device, and we could achieve the elimination of excess current supply by detecting the fiber voltage as well as the estimation of electric power supply without ineffective contraction. Consequently, the method in this study might be applied as a highly reliable totally implantable system.

  • Measurement of the pulmonary input impedance for development of a sophisticated pulmonary vascular resistance model

    TSUBOKO Yusuke, SHIRAISHI Yasuyuki, YAMADA Akihiro, SHIGA Takuya, SANO Kyosuke, YAMBE Tomoyuki

    日本生体医工学会大会プログラム・論文集(CD-ROM) 

    Presentation date: 2014.01

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved.The authors have been developing a pulmonary mechanical circulatory system in order to establish design parameters of artificial cardiovascular assist devices. In the quantitative examination of heart valves in pulmonary mock circulation, interactive changes in pressure and flow are regulated by pulmonary impedance characteristics. We focused on the native characteristics changes in impedance in the pulmonary circulation. To obtain the effect of respiratory control on pulmonary resistance, we measured pulmonary arterial pressure and flow in adult goat under the different respiratory settings with open- and closed-chest condition. We calculated pulmonary input impedance in two respiratory conditions under the anesthetized open-chest positive pressure ventilation (PPV) and the awake spontaneous respiration (SR). Longitudinal impedance in SR showed lower than in PPV. Characteristic impedance in SR was bigger than in PPV. Therefore, we concluded that the pulmonary impedance should be considered for more sophisticated simulation of pulmonary circulatory support devices.

  • Analysis of cardiovascular and autonomic nerve response to visual stress for preclinical medicine

    MIURA Hidekazu, TAKASAKI Eiko, YAMASHIGE Daiki, TAIRA Yasunori, YAMADA Akihiro, TSUBOKO Yusuke, SANO Kyosuke, SHIRAISHI Yasuyuki, YAMBE Tomoyuki

    日本生体医工学会大会プログラム・論文集(CD-ROM) 

    Presentation date: 2014.01

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    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved.Stress is an important factor when we consider responses in the cardiovascular and the autonomic nervous systems. After ethical committee allowance, responses in the cardiovascular system and autonomic nerve were evaluated with the individual characteristics. We investigated relationship between responses to the stress and individual characteristics. Healthy adult participants were assessed with type A scale, Beck depression scale, Hostility scale and Japanese Coronary-prone Behavior Scale (JCBS). Participants were showed hateful images and performed a mathematical task (Sudoku). Heart rate (HR), systolic blood pressure (SBP), LF/HF and pulse wave transmission time (PTT) were measured. The maximum value of the cross-correlation coefficients between BP and HR (ρ<inf>max</inf> BH), BP and PTT (ρ<inf>max</inf> BT) were analyzed. In both tasks, higher type A scored groups had larger LF/HF, suggesting that the individual characteristics were correlated with the autonomic nervous system. Significant correlation between the Beck depression score and the decrease in PTT and the increase in BP during hateful images were observed. High type A scored or high depression level had the relationship with the stress.

  • Design Diversity in Artificial Passive-Active Circulatory Support systems

    SHIRAISHI Yasuyuki, MIURA Hidekazu, TSUBOKO Yusuke, YAMADA Akihiro, KANEKO Yoshikazu, HASHEM Hashem, Mohamed Omran, SHIGA Takuya, KATAHIRA Shintaro, AKIYAMA Masatoshi, SAIKI Yoshikatsu, MORITA Kiyozo, YAMAGISHI Masaaki, QIAN Yi, YAMBE Tomoyuki, HOMMA Dai

    日本生体医工学会大会プログラム・論文集(CD-ROM) 

    Presentation date: 2014.01

     View Summary

    © 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved.We have been developing several variations of circulatory assist systems based on nano or micro engineering technologies. One of the special features of the design of these new styles of circulatory assist devices will be a passive controllability according to the native physiological signal transmission and hemodynamic responses. In this study, we presented the design features and the research diversity for the development of passive-active circulatory support systems, such as artificial myocardial assist devices, circulatory valves, epi-cardial or vascular support systems for mechanical assistance in chronic or congenital heart failure patients. We employed a covalent type shape memory alloy fiber as the actuator for the implantable artificial internal organs for sophisticated ventricular or hemodynamic support devices.

  • Hemodynamic Effect of an Atrial Contraction on Pulmonary Valve Functions in the Right Ventricular Simulator

    TSUBOKO Yusuke, SHIRAISHI Yasuyuki, MATSUO Satoshi, MIURA Hidekazu, YAMADA Akihiro, SHIGA Takuya, HASHEM Mohamed, Omran, ITO Takuya, SANO Kyosuke, TAIRA Yasunori, AKUTSU Toshinosuke, FENG Zhonggang, UMEZU Mitsuo, YAMAGISHI Masaaki, SAIKI Yoshikatsu, YAMBE Tomoyuki

    人工臓器(日本人工臓器学会) 

    Presentation date: 2013.09

  • Anisotropic structural design of an artificial esophagus based on pressure volume relation analysis of esophageal properties in goats

    TAIRA Yasunori, KAMIYA Kuraudp, SHIRAISHI Yasuyuki, MIURA Hidekazu, SHIGA Takuya, HASHEM Mohamed Omran, YAMADA Akihiro, TSUBOKO Yusuke, ITO Takuya, SANO Kyosuke, YAMBE Tomoyuki, HOMMA Dai

    人工臓器(日本人工臓器学会) 

    Presentation date: 2013.09

  • Electromechanical Modelling of the Transmission of Renal Nerve Activity for the Sophisticated Design of an Implantable Renal Nerve Cooling Device for Hypertension

    ITO Takuya, MIURA Hidekazu, SHIGA Takuya, HASHEM Mohamed Omran, KAMIYA Kurodo, YAMADA Akihiro, TSUBOKO Yusuke, SANO Kyosuke, TAIRA Yasunori, SHIRAISHI Yasuyuki, KUMAGAI Hiroo, YAMBE Tomoyuki

    人工臓器(日本人工臓器学会) 

    Presentation date: 2013.09

  • Functional improvement of a newly developed extra aortic Counter-pulsation device using Shape Memory Alloy Fibers

    HASHEM Mohamed Omran, SHIRAISHI Yasuyuki, YAMADA Akihiro, TSUBOKO Yusuke, MUIRA Hidekazu, YAMBE Tomoyuki, HOMMA Dai

    人工臓器(日本人工臓器学会) 

    Presentation date: 2013.09

  • 高血圧治療のための新しい完全埋込型能動的腎神経フィードバックシステム開発の基礎検討

    伊藤拓哉, 三浦英和, 志賀卓弥, MOHAMED Hashem, 山田昭博, 坪子侑佑, 白石泰之, 熊谷裕生, 山家智之

    バイオエンジニアリング講演会講演論文集 

    Presentation date: 2013.01

  • 右心房の収縮を考慮した肺動脈弁評価用シミュレータの改良

    坪子侑佑, 白石泰之, 山田昭博, 松尾諭志, 齋木佳克, FENG Zhonggang, 阿久津敏乃介, 田中隆, 梅津光生, 山岸正明, 山家智之

    バイオエンジニアリング講演会講演論文集 

    Presentation date: 2013.01

  • 1F17 Preliminary study on the development of an implantable renal nerve cooling device for blood pressure control

    ITO Takuya, MIURA Hidekazu, SHIGA Takuya, MOHAMED Hashem, YAMADA Akihiro, TSUBOKO Yusuke, SHIRAISHI Yasuyuki, KUMAGAI Hiroo, YAMBE Tomoyuki

    バイオエンジニアリング講演会講演論文集 

    Presentation date: 2013.01

  • 2C02 Improvement of a pulmonary circulatory system for the evaluation of right ventricular outflow tract reconstruction

    TSUBOKO Yusuke, SHIRAISHI Yasuyuki, YAMADA Akihiro, MATSUO Satoshi, SAIKI Yoshikatsu, FENG Zhonggang, AKUTSU Toshinosuke, TANAKA Takashi, Umezu Mitsuo, YAMAGISHI Masaaki, YAMBE Tomoyuki

    バイオエンジニアリング講演会講演論文集 

    Presentation date: 2013.01

  • 小児用肺動脈弁開発のための生体弁機能のモデル循環計測・評価

    坪子 侑佑, 白石 泰之, 山家 智之, 松尾 諭志, 齋木 佳克, 馮 忠剛, 梅津 光生, 宮崎 隆子, 山岸 正明

    バイオメカニズム学術講演会予稿集 

    Presentation date: 2012.12

  • 補助人工心臓用経皮的電力伝送システムの高度化に向けた開発研究

    三浦 英和, 山田 昭博, 坪子 侑祐, 伊藤 拓哉, 志賀 卓弥, ハシムモハメッド・オムラン, 白石 泰之, 山家 智之

    人工臓器 

    Presentation date: 2012.11

  • 遠心ポンプ型全置換型人工心臓の右心循環の動物実験モデルにおける右心房収縮のモニタリングの検討

    志賀卓弥, 三浦英和, 伊藤拓哉, 森谷葵, 坪子侑佑, 山田昭博, 神谷蔵人, ハシム モハメド, 白石泰之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2012.11

  • 心房細動治療のためのPID温度制御法を用いた心房冷却装置開発の基礎検討

    伊藤拓哉, 住吉剛忠, 三浦英和, 神谷蔵人, 志賀卓弥, HASHEM Mohammed, 山田昭博, 坪子侑佑, 森谷葵, 大沢上, 近内利明, 白石泰之, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2012.11

  • 極細形状記憶合金線維の多層化による人工心筋システムの改良

    白石泰之, 早津幸弘, 秋山正年, 北野智哉, 山田昭博, 坪子侑佑, 中島博行, 庄内千紘, 柏公一, 西條芳文, 齋木佳克, 本間大, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2012.11

  • 小児人工肺動脈弁機能評価のための新しい右心系模擬循環回路開発

    坪子侑佑, 鈴木一郎, 白石泰之, 山田昭博, 松尾諭志, 三浦英和, 西條芳文, 馮忠剛, 阿久津敏乃介, 梅津光生, 齋木佳克, 山家智之, 宮崎隆子, 山岸正明

    人工臓器(日本人工臓器学会) 

    Presentation date: 2012.11

  • 形状記憶合金を用いた小児用肺循環補助装置における動的駆動制御方法に関する基礎検討

    山田昭博, 白石泰之, 三浦英和, 志賀卓弥, ハセム モハメドオムラン, 神谷蔵人, 坪子侑佑, 森谷葵, 伊藤拓哉, 劉金龍, 銭逸, 山家智之, 山岸正明, 本間大

    人工臓器(日本人工臓器学会) 

    Presentation date: 2012.11

  • Primary study on the development of an extra aortic counter pulsation device using shape memory alloy fibers.

    HASHEM Mohamed, SHIRAISHI Yasuyuki, YAMADA Akihiro, TSUBOKO Yusuke, MIURA Hidekazu, YAMBE Tomoyuki, HOMMA Dai

    人工臓器(日本人工臓器学会) 

    Presentation date: 2012.11

  • 新しい小児用肺動脈弁改良設計のための逆解析の試み

    坪子侑佑, 鈴木一郎, SUGAI Telma Keiko, 山田昭博, 北野智哉, 志賀卓弥, 神谷蔵人, 白石泰之, 山家智之, 阿久津敏乃介, 馮忠剛, 梅津光生, 宮崎隆子, 山岸正明

    生体医工学 

    Presentation date: 2012.08

  • 左室乳頭筋モデルによる僧帽弁機能の基礎検討

    橋本尚, 白石泰之, SUGAI Telma Keiko, 志賀卓弥, 古賀千尋, 山田昭博, 坪子侑佑, 三浦英和, 西條芳文, 山家智之, 本間大

    生体医工学 

    Presentation date: 2012.08

  • 小児用肺循環補助装置の駆動方法に関する検討

    山田昭博, 白石泰之, SUGAI Telma Keiko, 三浦英和, 古賀千尋, 橋本尚, 坪子侑佑, 山家智之, 山岸正明, 本間大

    生体医工学 

    Presentation date: 2012.08

  • 小児用ePTFE肺動脈弁の最適設計モデリング

    坪子侑佑, 鈴木一郎, SUGAI Telma Keiko, 山田昭博, 北野智哉, 白石泰之, 三浦英和, 山家智之, 松尾諭志, 斎木佳克, 梅津光生, 宮崎隆子, 山岸正明

    バイオエンジニアリング講演会講演論文集 

    Presentation date: 2012.01

  • 8E12 Parametric estimation of modeling of an ePTFE paediatric pulmonary valve function using transvalvular hemodynamic data

    TSUBOKO Yusuke, SUGAI Telma Keiko

    バイオエンジニアリング講演会講演論文集 

    Presentation date: 2012.01

  • Prototyping of rotary blood pump for total artificial heart and rotational speed modulation for physiological blood flow

    MIURA Hidekazu, SHIGA Takuya, SHIRAISHI Yasuyuki, YAMADA Akihiro, TSUBOKO Yusuke, YAMBE Tomoyuki

    日本生体医工学会大会プログラム・論文集(CD-ROM) 

    Presentation date: 2012

  • Preliminary Study on Hydraulic Simulation with a Goat Heart for the Development of an Artificial Papillary Muscle

    SHIRAISHI Yasuyuki, HASHIMOTO Hisashi, TSUBOKO Yusuke, YAMADA Akihiro, SHIGA Takuya, KITANO Tomoya, MIURA Hidekazu, HOMMA Dai, YAMBE Tomoyuki

    日本生体医工学会大会プログラム・論文集(CD-ROM) 

    Presentation date: 2012

  • Preliminary study on the effect of extra-cardiac conduit contractile pressure on the mechanical Fontan circulation support

    YAMADA Akihiro, SHIRAISHI Yasuyuki, SUGAI Telma Keiko, MIURA Hidekazu, SHIGA Takuya, HASHEM Mohamed Omran, KOGA Chihiro, HASHIMOTO Hisashi, TSUBOKO Yusuke, YAMBE Tomoyuki, YAMAGISHI Masaaki, HOMMA Dai

    電気学会研究会資料. LD, リニアドライブ研究会 

    Presentation date: 2011.11

  • 生体僧房弁モデルを用いた力学検討に基づく人工乳頭筋設計

    橋本尚, 白石泰之, SUGAI Telma, 志賀卓弥, 神谷蔵人, MOHAMED Hashem, 北野智哉, 古賀千尋, 陳炯旬, 山田昭博, 坪子侑佑, 森谷葵, 三浦英和, 西條芳文, 山家智之, 本間大

    人工臓器(日本人工臓器学会) 

    Presentation date: 2011.10

  • Analyzing the interaction between the left atrium contraction and the centrifugal pump.

    MOHAMED Hashem, SHIRAISHI Yasuyuki, SUGAI Telma, KAMIYA Kuroudo, SHIGA Takuya, CHEN Jiongxun, KOGA Chihiro, HASHIMOTO Hisashi, YAMADA Akihiro, TUBOKO Yusuke, KITANO Tomoya, MIURA Hidekazu, LIU Hongjian, YAMAZAKI Kenji, YAMBE Tomoyuki

    人工臓器(日本人工臓器学会) 

    Presentation date: 2011.10

  • 小児用新型肺動脈人工弁設計における最適化のための新しい設計の基礎検討

    坪子侑佑, 鈴木一郎, 白石泰之, TELMA SUGAI Keiko, 北野智哉, 山田昭博, 志賀卓弥, 神谷蔵人, 劉江箭, 三浦英和, 西條芳文, 山家智之, 松尾諭志, 齋木佳克, 梅津光生, 宮崎隆子, 山岸正明

    人工臓器(日本人工臓器学会) 

    Presentation date: 2011.10

  • 遠心ポンプ型全置換型人工心臓における拍動流の椎骨動脈と腎動脈血流測定

    志賀卓弥, 三浦英和, 陳炯旬, 白石泰行, 劉紅箭, SUGAI Telma K, HASHEM Mohamed, Omran, 古賀千尋, 橋本尚, 山田昭博, 坪子侑佑, 森谷葵, 山家智之

    人工臓器(日本人工臓器学会) 

    Presentation date: 2011.10

  • 小児用新型肺動脈人工弁設計における最適化のための新しい設計の基礎検討

    坪子侑佑, 鈴木一郎, 山田昭博, 北野智哉, SUGAI Telma Keiko, 志賀卓弥, 神谷蔵人, 三浦英和, 白石泰之, 山家智之, 梅津光生, 宮崎隆子, 山岸正明

    日本機械学会東北支部秋季講演会講演論文集 

    Presentation date: 2011.09

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Syllabus

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Teaching Experience

  • Basics of Clinical Medicine I

    Tokyo University of Agriculture and Technology  

    2020.04
    -
    Now
     

  • Bioengineering

    Waseda University  

    2020.04
    -
    Now
     

  • Internal Organ Engineering

    Waseda University  

    2019.04
    -
    Now
     

  • Practical Medical Engineering

    Waseda University  

    2019.04
    -
    Now
     

  • Medical Electronics

    Sendai College of Medical Health  

    2014.04
    -
    2015.03
     

 

Committee Memberships

  • 2020.08
    -
    Now

    Japanese Society for Medical and Biological Engineering  Secretary

  • 2020.05
    -
    Now

    日本人工臓器学会  レギュラトリーサイエンス委員会 委員

  • 2020.05
    -
    Now

    日本人工臓器学会  医療産業促進委員会 委員

  • 2019.10
    -
    Now

    Japanese Society for Medical and Biological Engineering  Committee member, Research award and the Abe award selection committee

  • 2019.04
    -
    Now

    Japanese Society for Medical and Biological Engineering  Committee member, Young Researcher's Working Group

  • 2018.09
    -
    Now

    Medical Technology Association of Japan (MT Japan)  Committee member, ISO/TC 150 Japanese National Committee

  • 2018.08
    -
    Now

    Japanese Society for Medical and Biological Engineering  Secretary, International Committee

  • 2017.09
    -
    Now

    International Organization for Standardization (ISO)  Committee member, TC 150/SC 2/WG 1 (Cardiac valves)

  • 2017.09
    -
    Now

    International Organization for Standardization (ISO)  Committee member, TC 150/SC 2/WG 3 (Vascular prostheses)

  • 2017.05
    -
    Now

    Japanese Society for Artificial Organs  Council member

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Social Activities

  • TEPIA Advisor

    TEPIA Association for Technological Excellence Promoting 

    2019.06
    -
    Now

Media Coverage

Academic Activities

  • Program committee member, The 50th Annual Meeting for Artificial Heart and Assisted Circulation

    Academic society, research group, etc.

    人工心臓と補助循環懇話会  

    2022.04
     
     
  • Secretary-general, The 50th Annual Meeting for Artificial Heart and Assisted Circulation

    Academic society, research group, etc.

    人工心臓と補助循環懇話会  

    2022.04
     
     
  • 生体医工学サマースクール2021 実行委員

    Academic society, research group, etc.

    日本生体医工学会  

    2021.08
     
     
  • 第60回日本生体医工学会大会 Young Investigator's Award 審査委員

    Academic society, research group, etc.

    日本生体医工学会  

    2021.06
     
     
  • 日本生体医工学会関東支部若手研究者発表会2020 座長

    Academic society, research group, etc.

    日本生体医工学会  

    2020.12
     
     
  • Local Organizing Committee/Program Committee, 11th Asian Pacific Conference on Medical and Biological Engineering (APCBME 2020)

    Academic society, research group, etc.

    2020.05
     
     
  • 第59回日本生体医工学会大会 Young Investigator's Awardセッション 座長

    Academic society, research group, etc.

    日本生体医工学会  

    2020.05
     
     

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