2022/05/17 更新

写真a

ニシダ マサキ
西多 昌規
所属
スポーツ科学学術院 スポーツ科学部
職名
准教授
プロフィール

・睡眠や体内リズムと身体運動、スポーツとの関連性を、科学的に明らかにしていくことを目指しています。
・アスリートの睡眠障害や抑うつ・不安、発達障害など精神医学的な問題にも取り組んでいます。
・メンタルヘルス、ウェルビーイングに対する運動の有用性を明らかにしていきます。

兼担

  • スポーツ科学学術院   大学院スポーツ科学研究科

  • 附属機関・学校   グローバルエデュケーションセンター

学歴

  •  
    -
    1996年

    東京医科歯科大学   医学部   医学科  

学位

  • 東京医科歯科大学   博士(医学)

経歴

  • 2019年10月
    -
    継続中

    早稲田大学 睡眠研究所   所長

  • 2017年04月
    -
    継続中

    早稲田大学   スポーツ科学学術院   准教授

  • 2015年09月
    -
    2017年03月

    スタンフォード大学医学部   睡眠・生体リズム研究所   客員講師

  • 2011年10月
    -
    2017年03月

    自治医科大学精神医学教室   講師

  • 2013年07月
    -
    2014年06月

    自治医科大学附属病院   精神科   病棟医長

  • 2008年04月
    -
    2011年09月

    東京医科歯科大学大学院 精神行動医科学分野   助教

  • 2005年12月
    -
    2008年03月

    ハーバード大学医学部 ベス・イスラエル・ディコネス・メディカルセンター精神科 客員研究員

  • 2003年04月
    -
    2005年10月

    東京都精神医学総合研究所・睡眠障害部門   客員研究員

  • 2000年06月
    -
    2003年09月

    茨城県立友部病院

  • 1998年06月
    -
    2000年05月

    国立精神神経医療研究センター   レジデント

  •  
     
     

    早稲田大学 スポーツ科学学術院   准教授

▼全件表示

所属学協会

  • 2020年03月
    -
     

    日本ADHD学会

  • 2019年09月
    -
     

    日本体力医学会

  •  
     
     

    日本臨床スポーツ医学会

  •  
     
     

    日本スポーツ精神医学会

  •  
     
     

    Society for Neuroscience

  •  
     
     

    American Academy of Sleep Medicine

  •  
     
     

    日本老年精神医学会

  •  
     
     

    日本臨床神経生理学会

  •  
     
     

    日本睡眠学会

  •  
     
     

    日本精神神経学会

▼全件表示

 

研究分野

  • 実験心理学

  • スポーツ科学   睡眠科学

  • 内科学一般   睡眠医学

  • 栄養学、健康科学

  • 精神神経科学

研究キーワード

  • 睡眠科学

  • スポーツ医学

  • 認知科学

  • 臨床精神医学

  • 精神生理学

  • 睡眠医学

▼全件表示

論文

  • Effects of Sleep Restriction on Self-Reported Putting Performance in Golf.

    Masaki Nishida, Taishi Chiba, Yusuke Murata, Kohei Shioda

    Perceptual and motor skills     315125221087027 - 315125221087027  2022年04月  [査読有り]  [国際誌]

    担当区分:筆頭著者, 責任著者

     概要を見る

    In the present study, we aimed to explore the effects of sleep restriction (SR) on self-reported golf putting skills. Eleven collegiate golfers participated in a self-reported, counterbalanced experimental study under two conditions: (a) a SR condition in which sleep on the night prior to putting was restricted to 4-5 hours, and (b) a habitual normal sleep (NS) condition on the night before the putting test. Following each sleep condition, participants engaged in ten consecutive putting tests at 7 am, 11 am, and 3 pm. Participants reported their subjective sleepiness before each time frame, and their chronotype, defined as their individual circadian preference, was scored based on a morningness-eveningness questionnaire (MEQ). Participants restricted sleep to an average period of 267.6 minutes/night (SD = 51.2) in the SR condition and 426.2 (SD =38.0) minutes/night in the NS condition. A two-way analysis of variance revealed a significant main effect of the sleep condition on the lateral displacement of putts from the target (lateral misalignment) (p = 0.002). In addition, there was a significant main effect of time on distance from the target (distance misalignment) (p = 0.017), indicating less accuracy of putting in the SR condition. In the SR condition, the MEQ score was positively correlated with distance misalignment at 3 pm (ρ = 0.650, p = 0.030), suggesting that morningness types are susceptible to the effects of SR on putting performance. Our findings suggest that golfers should obtain sufficient sleep to optimize putting performance.

    DOI PubMed

  • Effect of napping on a bean bag chair on sleep stage, muscle activity, and heart rate variability

    Masaki Nishida, Atsushi Ichinose, Yusuke Murata, Kohei Shioda

    PeerJ   10   e13284 - e13284  2022年05月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Background

    Although ample evidence has demonstrated that daytime napping is beneficial for health and cognitive performance, bedding for napping has not yet been scientifically investigated.

    Objectives

    To explore the effect of a bean bag chair on daytime napping and physiological parameters related to sleep.

    Methods

    Fourteen healthy participants were enrolled within the context of a randomized, single-blind, crossover study to evaluate the effects of a bean bag chair in comparison with those of a urethane chair manufactured to have a similar shape. Electroencephalogram, electromyogram, and heart rate variability were recorded and compared between wakefulness and napping.

    Results

    Electroencephalogram analyses revealed no significant differences in sleep architecture or frequency components; however, a significant decrease was found in electromyogram recordings in the trapezius muscle, which represents the neck region (p = 0.019). Additionally, a significant main effect of bedding in the low-frequency/high-frequency ratio (F[1,20] = 4.314, p = 0.037) was revealed.

    Conclusions

    These results suggest that napping in a bean bag chair may provide a comfortable napping environment involving muscle relaxation and proper regulation of the autonomic nervous function.

    DOI

  • Mental health services at the Tokyo 2020 Olympic and Paralympic Games during the COVID-19 pandemic

    Masaki Nishida, Shunsuke Takagi, Tatsuya Yamaguchi, Hiroaki Yamamoto, Satoshi Yoshino, Kazuyoshi Yagishita, Takao Akama

    Sports Psychiatry   1   36 - 38  2022年01月  [査読有り]

    担当区分:筆頭著者, 責任著者

    DOI

  • Regular sleep quality and psychological state correlate in collegiate competitive springboard divers

    Masaki Nishida, Mirika Iwasa, Yusuke Murata

    Journal of Physical Education and Sport   22 ( 1 ) 100 - 108  2022年01月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Problem Statement: Mental health issues in athletes are gaining increasing attention, and proper sleep is an important factor for healthy mental health and improved athletic performance. Objectives: To explore the association between psychological evaluations regarding sports competitions and sleep quality in collegiate springboard divers. Methods: A cross-sectional study design was launched with 26 collegiate springboard diving athletes who answered a State-Trait Anxiety Inventory for evaluating anxiety as well as Diagnostic Inventory of Psychological-Competitive Ability for Athletes, a self-administered psychological questionnaire specific to competitive athletes. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and the correlation between psychological and sleep variables were assessed as well. Additionally, the psychological variables were compared between poor and normal sleep quality groups. Results: On psychological evaluation, PSQI scores showed significant negative correlations with results for self-control (ρ = −0.670, p < 0.001), ability to relax (ρ = −0.508, p < 0.001), and concentration (ρ = −0.589, p < 0.001). Significantly higher scores for self-control (p < 0.001), ability to relax (p = 0.004), and concentration (p = 0.001) were obtained in the normal sleep group compared to the poor sleep group. Conclusions: Our results suggest that sleep quality and duration are significantly related to psychological variables that reflect the domain of mental stability and concentration, especially the item of self-control. Additionally, the level of trait anxiety was considerably associated with poor sleep quality. Adequate sleep is essential to ameliorate the sense of self-control and vice versa. Considering that psychological testing is not practical because of its complexity as well as the attitude of athletes, sleep assessment can act as a convenient substitute for their psychological evaluation.

    DOI

  • Exploring the Effect of Long Naps on Handball Performance and Heart Rate Variability

    Masaki Nishida, Kei Yamamoto, Yusuke Murata, Atsushi Ichinose, Kohei Shioda

    Sports Medicine International Open   5 ( 03 ) E73 - E80  2021年12月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    <title>Abstract</title>This study explored the effect of long naps on handball-related performance and assessed the role of the cardiac autonomic nervous system in this process. Eleven male collegiate handball players performed a repeated sequential trial consisting of a 20-m consecutive turnaround run, 10-m run with a load, and shooting the ball into a target. Participants were allocated randomly and sequentially to have a short (20 minutes) nap, long (60 minutes) nap, or no nap. The Pittsburgh Sleep Quality Index was used to assess regular sleep quality. Subjective sleepiness before and after napping was measured using the Karolinska Sleepiness Scale. Heart rate variability was recorded to assess cardiac autonomic nervous function during napping. The Pittsburgh Sleep Quality Index score was correlated with shot accuracy only after long naps (ρ=0.636, r=0.048). A negative correlation was observed between the root mean square of successive differences and average load run time (ρ=−0.929, p&lt;0.001). Long napping was associated with a significant benefit on performance in athletes with poor sleep quality, implying a role of the autonomic nervous system in this regard. Our findings indicate the effect of sleep quality on the endurance and resistance of handball players.

    DOI

  • Mental rotation performance and circadian chronotype in university students: a preliminary study

    Masaki Nishida, Hiroki Ando, Yusuke Murata, Kohei Shioda

    Biological Rhythm Research     1 - 13  2021年02月  [査読有り]

    担当区分:筆頭著者, 責任著者

    DOI

  • Effect of Omitting Offset Work on Functional Near-Infrared Spectroscopy: Comparison Between Keyboard and Voice Response

    Senichiro Kikuchi, Yusuke Nishizawa, Kenji Tsuchiya, Kaori Shimoda, Fumikazu Miwakeichi, Hiroki Mori, Hideaki Tamai, Masaki Nishida

    JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING   40 ( 6 ) 899 - 907  2020年12月  [査読有り]

     概要を見る

    Purpose When examining cerebral activity, it is important to decrease a subject's fatigue with an appropriate task design that also maintains data quality. This study evaluated how well devices designed to reduce fatigue would affect functional near-infrared spectroscopy (fNIRS) data. Method A WOT-100 10-channel wearable fNIRS system was used to study the prefrontal areas of thirteen healthy volunteers. The stimulation task was a consistent incongruent Stroop test, but with two variations. First, the subjects' answers could be delivered either by vocalization or keyboard output. Second was whether or not there was an offset such as simple finger movements or vocalization during control periods. Four sessions using both variations were performed. The relative changes of fNIRS data during the stimulation periods were used as a marker for cerebral activity. Results There was only a significant difference in two channels (Channel 3: p = 0.040, Channel 9: p = 0.022) when voice output was used. Conclusion The result might have been due to voice output being generated from the temporal area, near the prefrontal area. We found that the omission of offset with keyboard output might be possible as there was only a small effect, but offset with voice output is necessary.

    DOI

  • Evaluations of effects of sleep surfaces on athletic performance in youth.

    Takashi Maruyama, Shinichi Sato, Mari Matsumura, Taisuke Ono, Masaki Nishida, Seiji Nishino

    Scientific reports   10 ( 1 ) 11805 - 11805  2020年07月  [査読有り]  [国際誌]

     概要を見る

    We recently demonstrated that sleeping on high rebound [HR] mattress toppers induced a continuous and more rapid decline in core body temperature compared to low rebound [LR] mattress toppers during the initial phase of nocturnal sleep in young healthy volunteers. HR toppers are characterized by their supportive feel and high breathability whereas LR toppers are pressure-absorbing. In the current study, we evaluated effects of HR mattress toppers on objectively-(actigraphy) and subjectively-(questionnaires) evaluated sleep, vigilance (psychomotor vigilance test), and athletic performance (40-m sprint time, long jump distance, and star drill time) in youth male athletes age 10-19, in two sessions: fifty-one subjects in 2013 (study I) and 23 subjects in 2014 (study II). Sleeping on HR mattress toppers for four to six weeks improved some athletic performance measures compared to sleeping on LR or sleeping directly on spring mattresses without a topper. Statistically significant improvements in 40-m sprint time in study I (compared to LR) and in star drill time in study II (no topper) were observed. No changes in sleep and psychomotor vigilance were observed. These results suggest selecting optimal sleep surfaces may contribute to the maximization of athletic performances, and further studies are warranted.

    DOI PubMed

  • Actigraphy in Patients With Major Depressive Disorder Undergoing Repetitive Transcranial Magnetic Stimulation An Open Label Pilot Study

    Masaki Nishida, Senichiro Kikuchi, Koichi Nisijima, Shiro Suda

    JOURNAL OF ECT   33 ( 1 ) 36 - 42  2017年03月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Background: The effects of repetitive transcranial magnetic stimulation (rTMS) on physical activity and sleep patterns in individuals with major depressive disorder (MDD) remain unclear.
    Method: We examined the effects of rTMS treatment on the rest-activity cycle and sleep disturbances in MDD. In this open-label pilot study, 14 patients with medication-resistant MDD underwent 10 rTMS sessions over the bilateral dorsolateral prefrontal cortex. In addition to Hamilton Depression Rating Scale and Pittsburgh Sleep Quality Index scores, waist actigraphy was used to evaluate alterations in the rest-activity cycle over the course of rTMS treatments. Actigraphic datawere evaluated at baseline and in the first (rTMS sessions 1-3), second (rTMS sessions 4-7), and third (rTMS sessions 8-10) sections.
    Results: Although Hamilton Depression Rating Scale and Pittsburgh Sleep Quality Index scores were significantly improved by rTMS, sleep variables assessed by actigraphy did not show significant changes. However, post hoc tests indicated a significant increase in mean steps per day between the baseline and first section time points (P = 0.014; t(13) = -2.316).
    Conclusions: Our data indicated that a daytime physical activity response to rTMS occurred in early sessions, whereas subjective symptom improvements were consistent across all sessions. Future double-blind placebo-controlled studies assessing the effects of rTMS on the restactivity cycle and sleep disturbances in MDD are warranted.

    DOI PubMed

  • Night duty and decreased brain activity of medical residents: a wearable optical topography study

    Masaki Nishida, Senichiro Kikuchi, Fumikazu Miwakeichi, Shiro Suda

    Medical Education Online   22 ( 1 ) 1379345 - 1379345  2017年01月  [査読有り]

    担当区分:筆頭著者, 責任著者

    DOI PubMed

  • Sleep complaints are associated with reduced left prefrontal activation during a verbal fluency task in patients with major depression: A multi-channel near-infrared spectroscopy study

    Masaki Nishida, Senichiro Kikuchi, Kenji Matsumoto, Yoshiki Yamauchi, Harumichi Saito, Shiro Suda

    JOURNAL OF AFFECTIVE DISORDERS   207   102 - 109  2017年01月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Background: Recent studies have indicated the potential clinical use of near-infrared spectroscopy (NIRS) as a tool for assisting in the diagnosis of major depressive disorder (MDD). Although sleep complaints are often manifested in MDD, no study has elucidated the possible association between the objective evaluation of sleep and NIRS signals in MDD.
    Methods: Fourteen patients with MDD and 15 healthy controls wore waist actigraphy equipment before the NIRS scan to investigate sleep parameters. We performed a 52-channel NIRS scan and measured changes in oxygenated hemoglobin ([oxy-Hb]) during a verbal fluency task.
    Results: In patients with MDD, a significant negative correlation was observed between the 17-item Hamilton Depressive Rating Scale score and cerebral reactivity of the right temporal region (p(s):=-0.804 to -0.762; FDR-corrected; p=0.008-0.012). The Pittsburgh Sleep Questionnaire Index, which enables assessment of continuous sleep quality and disturbances, was negatively correlated with [oxy-Hb] changes in the left prefrontal cortex (p(s)=-0.630 to -0.551; FDR-corrected; p=0.043-0.048). Actigraphic sleep variables prior to the NIRS measurement showed no significant correlation with [oxy-Hb] changes.
    Limitations: The limitations were small sample size with the low severity of depression and the use of actigraphy for only one night.
    Conclusion: Self-rated sleep disturbance were associated with decreased left prefrontal reactivity during a verbal fluency task in patients with MDD. Our result indicates that the reactivity of the prefrontal region is susceptible to sleep complaints, providing further evidence to support potential clinical application of NIRS.

    DOI PubMed

  • Jogging therapy for hikikomori social withdrawal and increased cerebral hemodynamics: A case report

    Masaki Nishida, Senichiro Kikuchi, Kazuhito Fukuda, Satoshi Kato

    Clinical Practice and Epidemiology in Mental Health   12   38 - 42  2016年04月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Severe social withdrawal, called hikikomori, has drawn increased public attention. However, an optimal clinical approach and strategy of treatment has not been well established. Here, we report a case of hikikomori for which an exercise intervention using jogging therapy was effective, showing cerebral hemodynamic improvement. The patient was a 20 year old Japanese male who was hospitalized in order to evaluate and treat severe social withdrawal. Although depressive and anxiety symptoms partially subsided with sertraline alone, social withdrawal persisted due to a lack of self confidence. With his consent, we implemented exercise therapy with 30 minutes of jogging three times a week for three months. We did not change the pharmacotherapy, and his social withdrawal remarkably improved with continuous jogging exercise. Using near infrared spectroscopy to evaluate hemodynamic alteration, bilateral temporal hemodynamics considerably increased after the three-month jogging therapy. Regarding exercise therapy for mental illness, numerous studies have reported the effectiveness of exercise therapy for major depression. This case implied, however, that the applicability of exercise therapy is not limited to major depressive disorder. Jogging therapy may contribute to reinforcing self confidence associated with "resilience" in conjunction with neurophysiological modulation of neural networks.

    DOI PubMed

  • Altered Sleep Spindles in Delayed Encephalopathy after Acute Carbon Monoxide Poisoning

    Takuya Yoshiike, Masaki Nishida, Kazuyoshi Yagishita, Tadashi Nariai, Kenji Ishii, Toru Nishikawa

    JOURNAL OF CLINICAL SLEEP MEDICINE   12 ( 6 ) 913 - 915  2016年  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Delayed encephalopathy (DE) affects not only the cerebral white matter and globus pallidus but also the cortex and thalamus. However, it remains unknown whether these brain lesions alter sleep along with clinical manifestations of DE. A 46-year-old man with DE underwent repetitive hyperbaric oxygen therapy. The patient was evaluated by not only neuropsychological and neuroimaging testing but polysomnography over the clinical course. Neurological symptoms improved markedly; however, profound frontal cognitive deficits continued. The polysomnography revealed prolonged absence and delayed

    DOI PubMed

  • Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder

    Masaki Nishida, Yusaku Nakashima, Toru Nishikawa

    Nature and Science of Sleep   8   63 - 72  2016年  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Introduction: Evidence has accumulated, which indicates that, in healthy individuals, sleep enhances procedural memory consolidation, and that sleep spindle activity modulates this process. However, whether sleep-dependent procedural memory consolidation occurs in patients medicated for major depressive disorder remains unclear, as are the pharmacological and physiological mechanisms that underlie this process. Methods: Healthy control participants (n=17) and patients medicated for major depressive disorder (n=11) were recruited and subjected to a finger-tapping motor sequence test (MST
    nondominant hand) paradigm to compare the averaged scores of different learning phases (presleep, postsleep, and overnight improvement). Participants' brain activity was recorded during sleep with 16 electroencephalography channels (between MSTs). Sleep scoring and frequency analyses were performed on the electroencephalography data. Additionally, we evaluated sleep spindle activity, which divided the spindles into fast-frequency spindle activity (12.5-16 Hz) and slow-frequency spindle activity (10.5-12.5 Hz). Result: Sleep-dependent motor memory consolidation in patients with depression was impaired in comparison with that in control participants. In patients with depression, age correlated negatively with overnight improvement. The duration of slow-wave sleep correlated with the magnitude of motor memory consolidation in patients with depression, but not in healthy controls. Slow-frequency spindle activity was associated with reduction in the magnitude of motor memory consolidation in both groups. Conclusion: Because the changes in slow-frequency spindle activity affected the thalamocortical network dysfunction in patients medicated for depression, dysregulated spindle generation may impair sleep-dependent memory consolidation. Our findings may help to elucidate the cognitive deficits that occur in patients with major depression both in the waking state and during sleep.

    DOI PubMed

  • 自治医科大学附属病院精神科における光トポグラフィー検査所見と臨床診断との一致率について

    菊地千一郎, 西多昌規, 齋藤陽道, 松本健二, 山内芳樹, 加藤敏, 菊地千一郎, 西多昌規, 齋藤陽道, 松本健二, 山内芳樹, 加藤敏

    栃木精神医学   34/35   38 - 42  2015年12月  [査読有り]

    J-GLOBAL

  • Mirtazapine-induced restless legs syndrome treated with pramipexole

    Akiko Makiguchi, Masaki Nishida, Katsutoshi Shioda, Shiro Suda, Koichi Nisijima, Satoshi Kato

    Journal of Neuropsychiatry and Clinical Neurosciences   27 ( 1 ) e76  2015年  [査読有り]

    担当区分:責任著者

    DOI PubMed

  • Topographical Distribution of Fast and Slow Sleep Spindles in Medicated Depressive Patients

    Masaki Nishida, Yusaku Nakashima, Toru Nishikawa

    JOURNAL OF CLINICAL NEUROPHYSIOLOGY   31 ( 5 ) 402 - 408  2014年10月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Purpose:To compare the properties of sleep spindles between healthy subjects and medicated patients with major depressive episode, including frequency range, spectra power, and spatial distribution of spindle power.Methods:Continuous 16-channel EEG was used to record nocturnal sleep in healthy control subjects and medicated depressive patients. Recordings were analyzed for changes in EEG power spectra and power topography. Additionally, we graphically demonstrated the pattern of spatial distribution of each type of sleep spindle, divided into fast (12.5-14 Hz) and slow spindles (11-12.5 Hz).Results:Sleep EEG records of depressive subjects exhibited a significantly higher amplitude of slow spindles in the prefrontal region, compared with the healthy controls (P &lt; 0.01). Fast spindles were dominant in the centroparietal region in both depressive patients and the control group. Enhanced slow spindles in the prefrontal region were observed in the medicated depressive patients and not in the healthy controls. The frequency of fast spindles in depressive patients was globally higher than that in healthy participants.Conclusions:The alteration in sleep spindles seen in medicated depressive subjects may reflect a pharmacological modulation of synaptic function involving the thalamic-reticular and thalamocortical mechanisms.

    DOI PubMed

  • Unilateral hippocampal infarction associated with an attempted suicide: A case report

    Yasushi Nishiyori, Masaki Nishida, Katsutoshi Shioda, Shiro Suda, Satoshi Kato

    Journal of Medical Case Reports   8 ( 1 ) 219  2014年06月  [査読有り]

    担当区分:責任著者

     概要を見る

    Introduction. In our case report we describe the case of a patient who experienced a stroke in her left hippocampus that was found following an attempted suicide via glyphosate overdose. To the best of our knowledge this is the first case report to describe a hippocampal infarction associated with a drug overdose. Case presentation. A 64-year-old Japanese woman was brought to our emergency department after ingestion of an unknown dose of glyphosate surfactant herbicide in order to attempt suicide. On admission, she was assumed to be presenting with depression or psychiatric illness, however, sudden-onset memory deficit became apparent. The patient manifested delirium, confusion, and severe anxiety. In addition, short-term memory loss was prominent, with the patient forgetting her attempted suicide. Following an array of standard tests and a brain computed tomography scan (which only showed an old infraction), we performed a magnetic resonance imaging scan and neuropsychological evaluations. The brain magnetic resonance image revealed a small high-intensity lesion in the dorsal part of the left hippocampal body, and memory tests demonstrated severe short-term recall deficits. We diagnosed her with a left hippocampal infarction and administered a course of 75mg of clopidogrel. She gradually became less confused over the course of a week, and a follow-up memory test revealed partial improvement in some domains. No abnormalities were found on a follow-up brain scan. However, despite rehabilitation, memory impairments remain. Conclusions: It is important to note that had the symptom of short-term memory been absent or less severe, she might have been misdiagnosed with depression or another psychiatric illness. Although a computed tomography scan failed to detect hippocampal lesions, a diffusion-weighted magnetic resonance imaging scan clearly revealed a lesion within the left hippocampus. Therefore, in addition to assessments focusing on psychiatric illnesses that might be the root cause of an attempted suicide, organic factors should be considered along with radiological examination and precise memory assessments for diagnosing similar cases. © 2014 Nishiyori et al.
    licensee BioMed Central Ltd.

    DOI PubMed

  • rTMS治療前後にNIRS検査を施行した3症例

    齋藤陽道, 菊地千一郎, 西多昌規, 松本健二, 小林亮子, 山内芳樹, 西嶋康一, 加藤敏

    精神医学   55 ( 7 ) 637 - 644  2013年07月  [査読有り]

    DOI J-GLOBAL

  • Relation between Parametric Change of the Workload and Prefrontal Cortex Activity during a Modified Version of the 'Rock, Paper, Scissors' Task

    Yoshiki Yamauchi, Senichiro Kikuchi, Fumikazu Miwakeichi, Kenji Matsumoto, Masaki Nishida, Makio Ishiguro, Eiju Watanabe, Satoshi Kato

    NEUROPSYCHOBIOLOGY   68 ( 1 ) 24 - 33  2013年  [査読有り]

     概要を見る

    Background/Aims: Modified rock, paper, scissors (RPS) tasks have previously been used in neuroscience to investigate activity of the prefrontal cortex (PFC). In this study, we investigated hemodynamic changes in the PFC using near-infrared spectroscopy (NIRS) during a modified RPS task in which each subject's successful performance rate was equalized; the workload was increased parametrically in order to reveal the resulting pattern of PFC activation. Methods: The subjects were 20 healthy adults. During RPS, the player uses hand gestures to represent rock, paper, and scissors. Rock beats scissors, paper beats rock, and scissors beats paper. In the modified RPS task, the player is instructed to lose intentionally against the computer hand; the computer goes first and the player follows. The interstimulus interval (ISI) level was adjusted with 11 steps. If the level rose, the ISI decreased and the workload increased parametrically. The maximal level (maxLv: the shortest ISI and the biggest workload) in which a subject could perform the task correctly was determined for every subject during rehearsal of the task prior to the experiment. Lowering the level from the maxLv made the task easier. Hemodynamic changes were measured by NIRS over 4 task levels (maxLv-3, maxLv-2, maxLv-1 and maxLv). Results: The hemodynamic changes in the left lateral PFC and bilateral Brodmann area 6 rose significantly with the increase in workload and presented a linear trend. Conclusion: These results suggest that PFC activation may linearly increase with increased workload during a modified RPS task in which successful performance rates of subjects are equalized. Copyright (c) 2013 S. Karger AG, Basel

    DOI PubMed

  • Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies: a case report

    Asami Ozaki, Masaki Nishida, Keiko Koyama, Kinya Ishikawa, Toru Nishikawa

    PSYCHOGERIATRICS   12 ( 4 ) 255 - 258  2012年12月  [査読有り]

    担当区分:責任著者

     概要を見る

    Here, we report a case of rapid eye movement sleep behavioural disorder in an elderly patient with dementia with Lewy bodies. Pretreatment polysomnography revealed atonia during rapid eye movement sleep, absence of sleep spindles and loss of slow-wave sleep. Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Pretreatment polysomnography performed after donepezil administration revealed a considerable number of sleep spindles. The effects of cholinergic modulation induced by donepezil seemed to cause remarkable improvement in mental status, incorporating associated with sleep spindles generated by the thalamocortical circuit involved in this patient.

    DOI PubMed

  • Sleep-Dependent Facilitation of Episodic Memory Details

    Els van der Helm, Ninad Gujar, Masaki Nishida, Matthew P. Walker

    PLOS ONE   6 ( 11 ) e27421  2011年11月  [査読有り]

     概要を見る

    While a role for sleep in declarative memory processing is established, the qualitative nature of this consolidation benefit, and the physiological mechanisms mediating it, remain debated. Here, we investigate the impact of sleep physiology on characteristics of episodic memory using an item- (memory elements) and context- (contextual details associated with those elements) learning paradigm; the latter being especially dependent on the hippocampus. Following back-to-back encoding of two word lists, each associated with a different context, participants were assigned to either a Nap-group, who obtained a 120-min nap, or a No Nap-group. Six hours post-encoding, participants performed a recognition test involving item-memory and context- memory judgments. In contrast to item- memory, which demonstrated no between-group differences, a significant benefit in context- memory developed in the Nap-group, the extent of which correlated both with the amount of stage-2 NREM sleep and frontal fast sleep-spindles. Furthermore, a difference was observed on the basis of word-list order, with the sleep benefit and associated physiological correlations being selective for the second word-list, learned last (most proximal to sleep). These findings suggest that sleep may preferentially benefit contextual (hippocampal-dependent) aspects of memory, supported by sleep-spindle oscillations, and that the temporal order of initial learning differentially determines subsequent offline consolidation.

    DOI PubMed

  • スポーツ外傷により脳の局所代謝変化を伴う特異な記憶障害を来した一症例

    白井 聖子, 西多 昌規, 田中 美穂, 宮森 孝史, 成相 直, 日浦 幹夫, 石井 賢二, 森田 定雄, 西川 徹

    スポーツ精神医学   8   59 - 63  2011年08月  [査読有り]

     概要を見る

    スポーツにおける外傷性の高次脳機能障害は多く症例報告されているが、臨床現場では診断が困難であることも多い。脳外傷例では損傷部位、損傷過程も多様であり、脳形態・機能画像においても責任部位を同定することが容易ではない。今回われわれは、スポーツ外傷によって特異的な記憶障害を呈した症例を経験した。右側頭部の打撲外傷のあと、記憶保持が3〜4日しかできない、特殊な記憶障害であった。リハビリテーションも導入し、受傷後2年で高次機能は完全に回復した。回復前後で、FDG-PETにおいて低下していた側頭葉脳代謝の著明な改善を認めた。頭部外傷が脳に与える障害の神経科学的なメカニズム、および回復過程も含めた治療、リハビリテーションについては、研究の途上の段階である。今後の外傷性高次脳機能障害の機序解明、治療の発展が期待される。(著者抄録)

  • Aripiprazoleのせん妄に対する有用性

    吉池卓也, 竹内崇, 佐々木健至, 石川洋世, 藤田宗久, 熱田英範, 正木秀和, 西多昌規, 行実知昭, 大島一成, 柏淳, 山本直樹, 車地暁生, 西川徹

    精神医学   53 ( 6 ) 543 - 549  2011年06月  [査読有り]

     概要を見る

    非定型抗精神病薬はせん妄の治療に広く用いられている。しかしながら,せん妄に対するaripiprazoleの報告は少ない。今回我々は,aripiprazoleのせん妄に対する有効性と安全性について検討したので報告する。対象はICD-10でせん妄と診断された患者17例で,有効性の判定には日本語版せん妄評価尺度98年改訂版の重症度得点を使用した。13例において有効性が認められ,有効率は76.5%であった。初回投与量は5.8±0.8mg/日,最大投与量は8.1±3.3mg/日,効果が最大に達するまでの日数は5.4±4.6日であった。ふらつきが3例(17.6%),眠気が2例(11.8%)に認められたが,重大な有害事象は認められなかった。以上から,aripiprazoleのせん妄に対する有効性と安全性が示唆された。今後さらなる研究が望まれる。(著者抄録)

    DOI CiNii

  • Memory deficits due to brain injury: Unique PET findings and dream alterations

    Masaki Nishida, Tadashi Nariai, Mikio Hiura, Kenji Ishii, Toru Nishikawa

    BMJ Case Reports   2011  2011年  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    The authors herein report the case of a young male with memory deficits due to a traumatic head injury, who presented with sleep-related symptoms such as hypersomnia and dream alterations. Although MRI and polysomnography showed no abnormalities, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and 11C flumazenil (FMZ)-PET revealed findings consistent with cerebral damage to the affected temporal region. The memory deficit of the patient gradually improved in parallel with the relief of the sleep-related symptoms. FDG-PET showed considerable improvement in glucose metabolism when he had recovered, however, evidence of neural loss remained in the FMZ-PET findings. Copyright 2011 BMJ Publishing Group. All rights reserved.

    DOI PubMed

  • A Role for REM Sleep in Recalibrating the Sensitivity of the Human Brain to Specific Emotions

    Ninad Gujar, Steven Andrew McDonald, Masaki Nishida, Matthew P. Walker

    CEREBRAL CORTEX   21 ( 1 ) 115 - 123  2011年01月  [査読有り]

     概要を見る

    Although the impact of sleep on cognitive function is increasingly well established, the role of sleep in modulating affective brain processes remains largely uncharacterized. Using a face recognition task, here we demonstrate an amplified reactivity to anger and fear emotions across the day, without sleep. However, an intervening nap blocked and even reversed this negative emotional reactivity to anger and fear while conversely enhancing ratings of positive (happy) expressions. Most interestingly, only those subjects who obtained rapid eye movement (REM) sleep displayed this remodulation of affective reactivity for the latter 2 emotion categories. Together, these results suggest that the evaluation of specific human emotions is not static across a daytime waking interval, showing a progressive reactivity toward threat-related negative expressions. However, an episode of sleep can reverse this predisposition, with REM sleep depotentiating negative reactivity toward fearful expressions while concomitantly facilitating recognition and ratings of reward-relevant positive expressions. These findings support the view that sleep, and specifically REM neurophysiology, may represent an important factor governing the optimal homeostasis of emotional brain regulation.

    DOI

  • 神経診察法の基本とピットフォール 精神症状と徴候

    西多 昌規, 西川 徹

    Clinical Neuroscience   28 ( 12 ) 1340 - 1341  2010年12月

  • スポーツ外傷により脳の局所代謝変化を伴う特異な記憶障害を来した一症例

    西多 昌規, 白井 聖子, 行実 知昭, 田中 美穂, 宮森 孝史, 成相 直, 日浦 幹夫, 石井 賢二, 森田 定雄, 西川 徹

    スポーツ精神医学   7   A25 - A25  2010年08月  [査読有り]

  • Understanding human biological rhythm. Therapeutic principles of bright light and melatonin for sleep disorders of circadian rhythm.

    Uchida S, Nishida M, Shioda K, Morita Y

    Indian J Sleep Med   5 ( 1 ) 8 - 12  2010年

  • REM Sleep, Prefrontal Theta, and the Consolidation of Human Emotional Memory

    Masaki Nishida, Jori Pearsall, Randy L. Buckner, Matthew P. Walker

    CEREBRAL CORTEX   19 ( 5 ) 1158 - 1166  2009年05月  [査読有り]

     概要を見る

    Both emotion and sleep are independently known to modulate declarative memory. Memory can be facilitated by emotion, leading to enhanced consolidation across increasing time delays. Sleep also facilitates offline memory processing, resulting in superior recall the next day. Here we explore whether rapid eye movement (REM) sleep, and aspects of its unique neurophysiology, underlie these convergent influences on memory. Using a nap paradigm, we measured the consolidation of neutral and negative emotional memories, and the association with REM-sleep electrophysiology. Subjects that napped showed a consolidation benefit for emotional but not neutral memories. The No-Nap control group showed no evidence of a consolidation benefit for either memory type. Within the Nap group, the extent of emotional memory facilitation was significantly correlated with the amount of REM sleep and also with right-dominant prefrontal theta power during REM. Together, these data support the role of REM-sleep neurobiology in the consolidation of emotional human memories, findings that have direct translational implications for affective psychiatric and mood disorders.

    DOI PubMed

  • Daytime Naps, Motor Memory Consolidation and Regionally Specific Sleep Spindles

    Masaki Nishida, Matthew P. Walker

    PLOS ONE   2 ( 4 ) e341  2007年04月  [査読有り]

     概要を見る

    Background. Increasing evidence demonstrates that motor-skill memories improve across a night of sleep, and that non-rapid eye movement (NREM) sleep commonly plays a role in orchestrating these consolidation enhancements. Here we show the benefit of a daytime nap on motor memory consolidation and its relationship not simply with global sleep-stage measures, but unique characteristics of sleep spindles at regionally specific locations; mapping to the corresponding memory representation. Methodology/Principal Findings. Two groups of subjects trained on a motor-skill task using their left hand-a paradigm known to result in overnight plastic changes in the contralateral, right motor cortex. Both groups trained in the morning and were tested 8 hr later, with one group obtaining a 60-90 minute intervening midday nap, while the other group remained awake. At testing, subjects that did not nap showed no significant performance improvement, yet those that did nap expressed a highly significant consolidation enhancement. Within the nap group, the amount of offline improvement showed a significant correlation with the global measure of stage-2 NREM sleep. However, topographical sleep spindle analysis revealed more precise correlations. Specifically, when spindle activity at the central electrode of the non-learning hemisphere (left) was subtracted from that in the learning hemisphere (right), representing the homeostatic difference following learning, strong positive relationships with offline memory improvement emerged-correlations that were not evident for either hemisphere alone. Conclusions/Significance. These results demonstrate that motor memories are dynamically facilitated across daytime naps, enhancements that are uniquely associated with electrophysiological events expressed at local, anatomically discrete locations of the brain.

    DOI PubMed

  • Prevalence and characteristics of depression in a Japanese leprosarium from the viewpoints of social stigmas and ageing. A preliminary report

    M. Nishida, Y. Nakamura, N. Aosaki

    LEPROSY REVIEW   77 ( 3 ) 203 - 209  2006年09月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    Objective To investigate the prevalence and characteristics of depressed patients living in a Japanese leprosarium who have been isolated by national law and are now becoming very elderly.
    Methods We surveyed the prevalence of depressed patients living in the National Tamazenshouen Sanatorium, a major leprosarium in Japan. We also investigated the characteristics of patients who had suffered a depressive episode during the last 5 years (2000-2004). The characteristics of residents who committed suicide were also studied.
    Results At the time of the investigation, 48 out of 385 (12.5%) patients were depressed or had experienced a depressive episode. Forty-one residents had committed suicide since the leprosarium was established in 1907. Somatic symptoms and depressive moods were the predominant symptoms and were not limited to symptoms unique to leprosy. The period of isolation was not statistically correlated with the GDS-SF or PGC morale scale scores.
    Conclusion The findings of this study emphasize the importance of consultation psychiatric for elderly leprosy residents and could be used as a reference for treatment in countries with ageing leprosy residents.

  • High frequency activities in the human orbitofrontal cortex in sleep-wake cycle

    M Nishida, S Uchida, N Hirai, F Miwakeichi, T Maehara, K Kawai, H Shimizu, S Kato

    NEUROSCIENCE LETTERS   379 ( 2 ) 110 - 115  2005年05月  [査読有り]

     概要を見る

    We recorded human orbitofrontal electrocorticogram during wakefulness and sleep in epileptic patients using subdural electrodes. During wakefulness and rapid eye movement (REM) sleep, we observed beta activity in the raw orbitofrontal signals. Power spectral analysis demonstrated beta enhancement during wakefulness and REM sleep when compared to slow wave sleep (SWS). During the phasic REM periods, the beta power was significantly lower than during the tonic REM periods. Gamma enhancement manifested itself in four out of six subjects during the phasic periods. This study is the first that has focused on electrical activity in the human orbitofrontal cortex. Although the role of the orbitofrontal cortex during sleep still remains unclear, high frequency activities give us important suggestions in elucidating the human sleep mechanism. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

    DOI PubMed

  • Theta oscillation in the human anterior cingulate cortex during all-night sleep: an electrocorticographic study

    M Nishida, N Hirai, F Miwakeichi, T Maehara, K Kawai, H Shimizu, S Uchida

    NEUROSCIENCE RESEARCH   50 ( 3 ) 331 - 341  2004年11月  [査読有り]

     概要を見る

    Ten epileptic patients each with subdural electrodes surgically attached to the anterior cingulate cortex (ACC; two cases), the orbitofrontal cortex (OFC: seven cases), or both (one case) were included in this study. We recorded each patient's ACC or OFC electrocorticogram (ECoG) during the time period that the patient was awake and naturally asleep. We performed a Fast Fourier Transformation (FFT) power spectral analysis on each ECoG to examine its frequency component. We found that the ACC showed regular and continuous theta oscillation (5-7Hz) during wakefulness and rapid eye movement (REM) sleep, but not during slow wave sleep. Theta waves observed in REM sleep were not as distinct as those found in wakefulness. We also discovered that the orbitofrontal signals represented spectral peaks in the theta band only during wakefulness. This suggests the coexistence of theta oscillation in the ACC. Considering our previous observations of gamma and beta oscillations in the human hippocampus, we hypothesize that the human limbic system manifests two oscillatory activities. The results obtained in this study suggest that electrophysiological activity in the ACC could be related to particular psychological functions in wakefulness and in REM sleep. These results are useful in elucidating the human brain mechanism. (C) 2004 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

    DOI PubMed CiNii

  • Impulse response function based on multivariate AR model can differentiate focal hemisphere in temporal lobe epilepsy

    F Miwakeichi, A Galka, S Uchida, H Arakaki, N Hirai, M Nishida, T Maehara, K Kawai, S Sunaga, H Shimizu

    EPILEPSY RESEARCH   61 ( 1-3 ) 73 - 87  2004年09月  [査読有り]

     概要を見る

    The purpose of this study is to propose and investigate a new approach for discriminating between focal and non-focal hemispheres in intractable temporal lobe epilepsy, based on applying multivariate time series analysis to the discharge-free background brain activity observed in nocturnal electrocorticogram (ECoG) time series.
    Five unilateral focal patients and one bilateral focal patient were studied. In order to detect the location of epileptic foci, linear multivariate autoregressive (MAR) models were fitted to the ECoG data; as a new approach for the purpose of summarizing these models in a single relevant parameter, the behaviour of the corresponding impulse response functions was studied and described by an attenuation coefficient.
    In the majority of unilateral focal patients, the averaged attenuation coefficient was found to be almost always significantly larger in the focal hemisphere, as compared to the non-focal hemisphere. Also the amplitude of the fluctuations of the attenuation coefficient was significantly larger in the focal hemisphere. Moreover, in one patient showing a typical regular sleep cycle, the attenuation coefficient in the focal hemisphere tended to be larger during REM sleep and smaller during Non-REM sleep. In the bilateral focal patient, no statistically significant distinction between the hemispheres was found.
    This study provides encouraging results for new investigations of brain dynamics by multivariate parametric modeling. It opens up the possibility of relating diseases like epilepsy to the properties of inconspicuous background brain dynamics, without the need to record and analyze epileptic seizures or other evidently pathological waveforms. (C) 2004 Elsevier B.V. All rights reserved.

    DOI PubMed

  • Use of perospirone for obesity and diabetes mellitus in patients with schizophrenia: three case reports

    M Nishida, M Nakamura

    INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY   19 ( 1 ) 41 - 43  2004年01月  [査読有り]

    担当区分:筆頭著者, 責任著者

     概要を見る

    We report that perospirone may have had positive effects on the obesity of three patients with schizophrenia and on the fasting blood sugar (FBS) and HbA1C of two of them who had type 2 diabetes mellitus. (C) 2004 Lippincott Williams Wilkins.

    DOI

  • Does hippocampal theta exist in the human brain?

    Uchida S, Nishida M, Hirai N

    Neurobiology of Sleep Wakefulness Cycle   1   1 - 8  2001年  [査読有り]

  • Benign adult familial myoclonus epilepsy with depressive state: A case report

    M Nishida, M Kato, S Uchida, T Onuma

    NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH   9 ( 1 ) 37 - 40  2001年  [査読有り]

     概要を見る

    Benign adult familial myoclonus epilepsy (BAFME) is a rare epileptic disease that has predominantly been reported in the Japanese population. To date, there have been no reports of psychotic symptoms in BAFME patients. We recently encountered one patient with BAFME accompanied by an apparently related major depressive episode. The depressive state did not improve after trials of several antidepressive agents, including clomipramine, fluvoxamine and alprazolam. However, clonazapam was very effective and immediately improved both the affective disorder and epileptic symptoms. Electroencephalographic (EEG) findings also improved, reflected by normalization of background activity and spikey waves. This clinical course could indicate that the depressive state derived from epileptic pathophysiology.

▼全件表示

書籍等出版物

  • アスレティックパフォーマンス向上のためのトレーニングとリカバリーの科学的基礎

    平山, 邦明 西多, 昌規( 担当: 分担執筆,  担当範囲: 睡眠と疲労、リカバリー)

    文光堂  2021年11月 ISBN: 9784830651939

  • リモート疲れとストレスを癒す「休む技術」 : オンラインワークの心と身体をケアする56のコツ

    西多, 昌規

    大和書房  2021年08月 ISBN: 9784479785385

  • アスリートのメンタルケア : 選手の心の悩みケースブック

    内田, 直, 西多, 昌規, 関口, 邦子, 石原, 心( 担当: 共著)

    大修館書店  2020年04月 ISBN: 9784469268850

  • ヒトの概日時計と時間

    時間学の構築編集委員会, 山口大学時間学研究所( 担当: 分担執筆)

    恒星社厚生閣  2019年03月 ISBN: 9784769916321

  • 休む技術

    西多, 昌規( 担当: 単著)

    大和書房  2017年09月 ISBN: 9784479306689

  • 自分の「異常性」に気づかない人たち : 病識と否認の心理

    西多, 昌規

    草思社  2016年11月 ISBN: 9784794222367

  • 「引きずらない」人の習慣 : 怒り、悲しみ、不安のワナにハマらない

    西多, 昌規

    PHPエディターズ・グループ  2016年 ISBN: 9784569829821

  • ぼんやり脳! : 上手にボーッとできる人は仕事も人生もうまくいく

    西多, 昌規

    飛鳥新社  2016年 ISBN: 9784864104593

  • 職場にいる不機嫌な人たち

    西多, 昌規

    KADOKAWA  2016年 ISBN: 9784046015488

  • 「昨日の疲れ」が抜けなくなったら読む本 : こころとからだをリセットする42の新習慣

    西多, 昌規

    大和書房  2016年 ISBN: 9784479305996

  • めんどくさくて、「なんだかやる気が出ない」がなくなる本

    西多, 昌規

    SBクリエイティブ  2016年 ISBN: 9784797388763

  • 感情に振り回されない技術 : 穏やかで前向きなこころを手に入れる44の習慣

    西多, 昌規

    大和書房  2015年11月 ISBN: 9784479783381

  • 「テンパらない」技術 : 図解 : 「頭が真っ白」になっても、とっさに心を立て直せる

    西多, 昌規

    PHP研究所  2015年 ISBN: 9784569823898

  • 悪夢障害

    西多, 昌規

    幻冬舎  2015年 ISBN: 9784344983939

  • 脳と体の疲れをとる仮眠術 : パワーナップの大効果!

    西多, 昌規

    青春出版社  2014年10月 ISBN: 9784413044349

  • 図解「昨日の疲れ」が抜けなくなったら読む本 : 休み方にもコツがある!

    西多, 昌規

    大和書房  2014年 ISBN: 9784479782827

  • 精神科医が教える「集中力」のレッスン : 「気が散る」「すぐに疲れる」「調子が出ない」を乗り越える46のヒント

    西多, 昌規

    大和書房  2014年 ISBN: 9784479782964

  • 「しがみつかない」人ほどうまくいく

    西多, 昌規

    PHPエディターズ・グループ,PHP研究所 (発売)  2014年 ISBN: 9784569817446

  • 睡眠とその障害のクリニカルクエスチョン200

    西多昌規( 担当: 共著)

    2013年12月 ISBN: 4787820400

  • 疲れる相手の話をきちんと聞く49のコツ

    西多, 昌規

    実務教育出版  2013年11月 ISBN: 9784788910713

  • 病んだ部下とのつきあい方 : 精神科医が教える上司の心得

    西多, 昌規

    中央公論新社  2013年10月 ISBN: 9784121504722

  • 眠る技術 : 「起きられない」「寝た気がしない」「やる気が出ない」あなたへ

    西多, 昌規

    大和書房  2013年10月 ISBN: 9784479304524

  • ジェネラル診療シリーズ あらゆる診療科でよく出会う精神疾患を見極め、対応する適切な診断・治療と患者への説明、専門医との連携のために

    西多昌規( 担当: 共著,  担当範囲: 隠れている軽い統合失調症を発見するには)

    羊十社  2013年03月 ISBN: 4758115036

  • 「凹まない」技術

    西多, 昌規

    PHP研究所  2013年 ISBN: 9784569679556

  • 「失敗」は脳から消せる : 「苦手意識」をなくす技術

    西多, 昌規

    アース・スターエンターテイメント,泰文堂 (発売)  2013年 ISBN: 9784803004571

  • 休む技術 : かしこくコスパを上げる大人のオン・オフ術

    西多, 昌規

    大和書房  2013年 ISBN: 9784479782605

  • 「疲れない!」技術

    西多, 昌規

    ソフトバンククリエイティブ  2013年 ISBN: 9784797374452

  • 大事なときに限ってうまく話せない人のための人前であがらない技術

    西多, 昌規

    中経出版  2013年 ISBN: 9784806146810

  • 脳がスッキリする技術

    西多, 昌規

    宝島社  2012年12月 ISBN: 9784800201430

  • 水曜日に「疲れた」とつぶやかない50の方法

    西多, 昌規

    朝日新聞出版  2012年 ISBN: 9784022734518

  • 「月曜日がゆううつ」になったら読む本 : 仕事で疲れたこころを元気にするリセットプラン39

    西多, 昌規

    大和書房  2012年 ISBN: 9784479782438

  • 「テンパらない」技術

    西多, 昌規

    PHP研究所  2012年 ISBN: 9784569678337

  • 今の働き方が「しんどい」と思ったときのがんばらない技術

    西多, 昌規

    ダイヤモンド社  2012年 ISBN: 9784478022160

  • 眠りの科学とその応用 Ⅱ

    西多昌規( 担当: 共著,  担当範囲: 睡眠と脳の情報処理機構)

    シーエムシー出版  2011年12月 ISBN: 9784781305202

  • 緊急度・重症度からみた 症状別看護過程+病態関連図

    西多昌規( 担当: 共著,  担当範囲: 不安)

    医学書院  2011年11月 ISBN: 9784260011365

  • 1行リフレッシュ術 : Refresh method for mind & body

    西多, 昌規

    イースト・プレス  2011年11月 ISBN: 9784781606774

  • 神経診察:実際とその意義

    西多昌規( 担当: 共著)

    中外医学社  2011年 ISBN: 9784498128866

  • 「昨日の疲れ」が抜けなくなったら読む本 : こころとからだをリセットする41の新習慣

    西多, 昌規

    大和書房  2011年 ISBN: 9784479782285

  • 「器が小さい人」にならないための50の行動 : 脳科学が教えるベストな感情コントロール法

    西多, 昌規

    草思社  2011年 ISBN: 9784794218469

  • 60歳からのボケない熟睡法

    西多, 昌規

    青春出版社  2011年 ISBN: 9784413043281

  • 脳を休める 脳科学と睡眠の新しい常識

    西多昌規( 担当: 単著)

    ファーストプレス  2009年10月 ISBN: 4904336372

  • 脳を休める : 脳科学と睡眠の新しい常識

    西多, 昌規

    ファーストプレス  2009年10月 ISBN: 9784904336373

  • 睡眠検査学の基礎と臨床

    西多昌規( 担当: 共著)

    新興医学出版社  2009年 ISBN: 9784880026923

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Misc

  • 間歇型一酸化炭素中毒の臨床経過と睡眠脳波の変化について検討した1症例

    吉池 卓也, 西多 昌規, 谷 顕, 細田 益宏, 熱田 英範, 柳下 和慶, 西川 徹

    精神神経学雑誌   ( 2012特別 ) S - 437  2012年05月

  • 高齢者の気分障害入院患者に関する臨床的研究

    車地 曉生, 大島 一成, 行実 知昭, 古田 光, 正木 秀和, 熱田 英範, 平沢 俊行, 新垣 浩, 寺田 倫, 川上 礼子, 柏 淳, 吉池 卓也, 西多 昌規, 藤田 宗久, 上里 彰仁, 成島 健二, 筒井 啓太, 西川 徹

    精神神経学雑誌   ( 2011特別 ) S - 222  2011年10月

  • 双極性障害入院患者の発症および前駆症状に関する後方視的研究

    車地曉生, 大島一成, 行実知昭, 古田光, 正木秀和, 熱田英範, 平沢俊行, 新垣浩, 寺田倫, 川上礼子, 吉池卓也, 西多昌規, 藤田宗久, 西川徹

    Bipolar Disorder   8   15 - 21  2010年06月  [査読有り]

  • 自殺関連行動によりERセンター救急科に入院した患者の抗うつ薬の服薬状況

    竹内 崇, 石川 洋世, 吉池 卓也, 藤田 宗久, 上里 彰仁, 行実 知昭, 熱田 英範, 西多 昌規, 大島 一成, 柏 淳, 山本 直樹, 車地 暁生, 西川 徹

    精神神経学雑誌   ( 2009特別 ) S - 414  2009年05月

  • Theta oscillation in the human anterior cingulate cortex during all-night sleep: An electrocorticographic study (vol 50, pg 331, 2004)

    Masaki Nishida, Nobuhide Hirai, Fumikazu Miwakeichi, Taketoshi Maehara, Kensuke Kawai, Hiroyuki Shimizu, Sunao Uchida

    NEUROSCIENCE RESEARCH   58 ( 2 ) 215 - 217  2007年06月

    その他  

    DOI

  • 脳波・筋電図の臨床 ヒトの辺縁系における覚醒睡眠時の脳波律動

    内田 直, 西多 昌規, 平井 伸英, 川合 謙介, 清水 弘之, 前原 健寿

    臨床脳波   44 ( 6 ) 361 - 366  2002年06月

     概要を見る

    深部の大脳皮質の活動記録及び皮質の局所的な電気活動記録を用いて,大脳皮質における覚醒睡眠時の皮質脳波律動について検討した.その結果,高周波ガンマ活動は常に出現していたが,除波睡眠期には出現量が減少した.ベータ1律動では,覚醒時と除波睡眠期に限定した出現が見られ,周波数ピークはレム睡眠期で有意に低かった.更に,前帯状回に規則的なシータ帯域の律動が存在することが明らかとなった

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産業財産権

  • 気分障害患者と健常人とを識別する装置

    西多 昌規, ソニー株式会社

    特許権

受賞

  • 第88回 日本産業衛生学会 優秀演題賞

    2015年06月  

    受賞者: 西多 昌規

  • 第15回 日本睡眠学会 研究奨励賞

    2010年  

共同研究・競争的資金等の研究課題

  • 睡眠慣性、覚醒度が身体運動に与える影響の時間学的検討

    日本学術振興会  科学研究費助成事業 基盤研究(C)

    研究期間:

    2021年04月
    -
    2024年03月
     

    西多 昌規, 塩田 耕平

  • カンナビジオールが夜間睡眠に与える影響についての生理学的研究

    Dropstone(株) 

    研究期間:

    2021年06月
    -
    2023年05月
     

    西多昌規

  • 短時間仮眠による認知的および身体的疲労回復効果

    日本学術振興会  科学研究費助成事業 基盤研究(C)

    研究期間:

    2020年04月
    -
    2023年03月
     

    塩田 耕平, 西多 昌規

  • 夜間睡眠における高反発マットレスに関する研究

    ライズTOKYO株式会社 

    研究期間:

    2019年10月
    -
    2021年09月
     

    西多昌規

  • 睡眠環境の最適化に関する生理学的研究.

    株式会社 ウェブシャーク 

    研究期間:

    2019年08月
    -
    2021年07月
     

    西多昌規

  • 睡眠時間が身体運動に与える影響についての精神生理学的研究

    日本学術振興会  科学研究費助成事業 基盤研究(C)

    研究期間:

    2018年04月
    -
    2021年03月
     

    西多 昌規

     概要を見る

    本研究は、慢性的な睡眠不足(睡眠負債)とスポーツ関連の身体運動との関連を検討する。得られた結果を踏まえて、睡眠時間の延長によって身体運動機能が回復・向上する機序の解明を目指すものである。24時間型の現代社会で問題となっている睡眠負債は、スポーツを含む身体運動に負の影響をおよぼしているにもかかわらず、脳神経基盤に焦点を当てた研究は少ない。これら一連の研究成果を踏まえ、睡眠負債の蓄積、さらに睡眠時間の延長が身体運動に与える影響を精神生理学的に検討し、その機序を解明しようと試みる。
    <BR>
    具体的には、睡眠負債が運動機能を低下させるメカニズムを解明するために、睡眠負債が運動関連の高次機能に及ぼす影響を精神生理学的に調べる。睡眠時間を2週間にわたって通常より2時間程度短縮させた群(睡眠負債群)と睡眠時間を2週間にわたって通常より2時間程度延長させた群(睡眠延長群)、比較対照群を対象に実験を行う。介入開始前と介入1週間後、2週間後、介入終了後1週間後に、睡眠および高次機能の評価をそれぞれ行う。スポーツ関連の遂行機能として、サッカーを主題としたLSPT(Loughborough Soccer Passing Test)を採用し、高次機能の客観的評価として注意機能を測定するPVT(Psychomotor vigilance task)を計測する。
    <BR>
    目標としては、今後得られる実験結果を分析し、主にアスリートを対象に、神経科学・認知科学の点から運動機能を向上させる睡眠指針の確立につなげていきたい。

  • 運動機能回復に関わるエラーモニタリングの神経機序解明

    日本学術振興会  科学研究費助成事業 基盤研究(B)

    研究期間:

    2017年04月
    -
    2021年03月
     

    正木 宏明, 広瀬 統一, 小野田 慶一, 西多 昌規, 小川 景子

     概要を見る

    平成30年度では,ピアノ演奏のようにクロスモーダルで複雑な手指系列動作の学習に対してtDCSが促進効果をもたらすかについて検証した.参加者(ピアノ未経験者)をtDCS群とsham群に振り分け,課題曲(バッハメヌエットト長調)を20試行反復練習してもらった.陽極電極を頭皮上C3,陰極電極をC4位置に装着し,練習中に1 mAで10分間刺激した.練習直後と1日後には,保持テストと転移テストを実施した.パフォーマンス(打鍵タイミング精度)について群(2)×練習試行(20)の2要因分散分析を行った結果,練習の主効果は認められたが,tDCSの効果はなかった.交互作用も有意でなかった.両テストともパフォーマンスに群間差はなく,tDCSの促進効果に関する従来の知見を再現できなかった.その原因に課題難度の設定不良が示唆されたため,今後は課題難度を調整する.
    ACL受傷アスリートのリハビリテーション過程における脳波データの取得を開始した.ACLの症例が少なかったため,十分なデータを得ることができなかった.研究期間の残り2年間を通してデータ取得を継続する.
    運動学習と終夜睡眠の関係を調べた実験ではデータ分析を進めており,フィードバック関連陰性電位が睡眠前よりも睡眠後に大きくなる傾向がみられた.令和元年度では,昼間睡眠実験においてスピンドルの有無等の視点から,運動スキルの記憶固定について検討する.早稲田大学・西多が新たに参画し,実験を実施する.
    予定していたfMRI実験は見合わせた.その理由は,平成30年度に現有1.5テスラから3テスラMR装置への入れ替え作業が生じたことにある.ただし,事象関連デザイン実験に必要な課題装置作成と実験制御プログラミングを島根大学・小野田と正木で完遂することができた.新規MR装置導入が完了したことから,令和元年度より,力量発揮課題を用いた運動学習実験を実施する.

  • 医療従事者の睡眠状態と脳高次機能についての生理学的研究

    日本学術振興会  科学研究費助成事業 基盤研究(C)

    研究期間:

    2013年04月
    -
    2016年03月
     

    西多 昌規, 須田 史朗, 菊地 千一郎, 加藤 敏

     概要を見る

    医療従事者の疲労・睡眠不足は、医療事故の温床である。本研究では研修医を対象に、当直前後での採血手技中の脳血液量変化を比較検討した。当直前後において、採血練習用の模擬血管を協力者に装着し、被験者に採血手技を行わせた。被験者にはウェアラブル光トポグラフィを装着し、関心領域を前額部付近として採血手技中の脳血液量変化を記録し解析を行った。当直後における2回の採血手技で比較したところ、2回目は1回目に比較して、右前頭前皮質領域の有意な血流量変化の減少が認められた。ヒヤリ・ハットに通じるイージーミスを発生しやすい神経学的証拠であると考えられた。

  • 胎生期低栄養によって精神疾患発症脆弱性が生じるメカニズムを探る

    日本学術振興会  科学研究費助成事業 基盤研究(C)

    研究期間:

    2013年04月
    -
    2016年03月
     

    須田 史朗, 塩田 勝利, 西多 昌規, 武井 教使

     概要を見る

    わが国では低出生体重児が増加傾向にある。疫学研究の成果から、その原因の一端である胎生期低栄養は統合失調症をはじめとする精神疾患の発症脆弱性を生じさせることが示されており、早急な対策が求められている。本研究では胎生期低栄養と精神疾患発症脆弱性の形成との関連を検討するために、ラットを用いは胎生期低栄養暴露による動物モデルを作成した。胎生期の低栄養暴露と出生時体重の減少との関連は明らかであった。組織学的検討から、胎生期の低栄養暴露と成人期の海馬神経新生の低下との関連を示唆する結果が得られた。妊娠期間中の母ラットに対する観察から、母体への低栄養暴露が母性行動に変化を与える可能性も示唆された。

  • 医療従事者の睡眠状態と脳高次機能についての生理学的研究

    日本学術振興会  科学研究費

    研究期間:

    2014年04月
    -
    2016年03月
     

    西多 昌規

  • グルタミン酸受容体機能制御による統合失調症の新規治療法開発に関する研究

    日本学術振興会  科学研究費助成事業 基盤研究(B)

    研究期間:

    2009年
    -
    2011年
     

    西川 徹, 山本 直樹, 車地 暁生, 竹内 崇, 西多 昌規, 熱田 英範

     概要を見る

    多くの統合失調症患者の社会復帰を阻む、既存の治療薬に抵抗する症状の病態解析と治療法開発のため、NMDA型グルタミン酸受容体遮断薬が、これらの難治症状類似の異常を引き起こすことに注目し、本受容体機能調節の分子細胞機構を検討した。本受容体の生理的な働きに不可欠な脳内D-セリンの、組織中・細胞外中の濃度調節に関する、薬物の影響や、酵素・イオンの役割について新たな所見が得られ、さらなる検討に必要な遺伝子操作マウスの作製が進展した。

  • グルタミン酸伝達調節による難治性統合失調症状の新規治療法開発に関する研究

    日本学術振興会  科学研究費助成事業 基盤研究(B)

    研究期間:

    2007年
    -
    2008年
     

    西川 徹, 山本 直樹, 大島 一成, 正木 秀和, 西多 昌規, 塩入 明子

     概要を見る

    フェンサイクリジンなどのNMDA型グルタミン酸受容体遮断薬が惹起する統合失調症様状態において、抗精神病薬反応性の陽性症状とともに難治性の陰性症状や認知障害と酷似した異常が見られる現象にもとづき、NMDA受容体機能を促進することにより双方の症状を改善する次世代の治療法の開発に関する研究を進めた。NMDA受容体機能を促進する内在性物質D-セリンの代謝について、(1) 内側前頭葉皮質でD-サイクロセリンにより細胞外濃度が選択的に上昇することが確認された、(2) clozapineは細胞外L-グルタミン酸濃度を軽度増加させるがD-セリンには影響しない、(3) 内側前頭葉皮質において神経細胞体またはグリア細胞の選択的破壊によってD-セリン濃度が減少する、(4) 大脳新皮質のニューロンおよびグリアの初代培養系でD-セリンの免疫反応と細胞外への放出が見られる等の所見が得られ、D-セリンのシグナルは薬物によって制御できる可能性があるが、このためには、グルタミン酸シナプスーグリア系の分子細胞メカニズムをさらに検討し、新規治療薬の分子標的を明らかにする必要があると考えられた。その候補のひとつとして、研究代表者らがクローニングした、D-セリンの細胞内外の濃度に影響する遺伝子D-serinemodulator-1に着目し、欠失マウスの作出を行った。また、NMDA受容体のアロステリック部分作動薬であるD-サイクロセリンを、抗精神病薬服用中の統合失調症患者に併用投与する臨床試験を進めた。

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現在担当している科目

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委員歴

  • 2012年09月
    -
    継続中

    日本アンチ・ドーピング機構  審査員

  • 2012年07月
    -
    継続中

    日本スポーツ協会  公認スポーツドクター

  • 2009年10月
    -
     

    日本スポーツ精神医学会  理事

  •  
     
     

    日本老年精神医学会 会員 専門医

  •  
     
     

    Society for Neuroscience  会員

  •  
     
     

    American Academy of Sleep Medicine  会員

  •  
     
     

    日本臨床神経生理学会  会員、認定医(脳波部門)

  •  
     
     

    日本睡眠学会  専門医・評議員

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    日本精神神経学会  会員、専門医、指導医

  •  
     
     

    OSCE外部評価委員

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