NAKAGAWA, Kento

写真a

Affiliation

Faculty of Sport Sciences, School of Sport and Sciences

Job title

Assistant Professor(without tenure)
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Research Experience 【 display / non-display 】

  • 2018.04
    -
    2019.03

    日本学術振興会 海外特別研究員 (Toronto Rehabilitation Institute)

  • 2015.04
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    2018.03

    日本学術振興会   特別研究員 PD (東京大学)

  • 2014.04
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    2015.03

    Waseda University   Faculty of Sport Sciences

  • 2012.04
    -
    2014.03

    日本学術振興会 特別研究員 DC2 (早稲田大学)

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Professional Memberships 【 display / non-display 】

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    JAPAN SOCIETY OF PHYSICAL EDUCATION, HEALTH AND SPORT SCIENCES

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    THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE

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    EUROPEAN COLLEGE OF SPORT SCIENCE

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    THE JAPANESE SOCIETY FOR MOTOR CONTROL

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    SOCIETY FOR NEUROSCIENCE

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Research Areas 【 display / non-display 】

  • Physical education, and physical and health education

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Papers 【 display / non-display 】

  • Para-Sports can Promote Functional Reorganization in the Ipsilateral Primary Motor Cortex of Lower Limbs Amputee

    Tomoya Nakanishi, Nobuaki Mizuguchi, Kento Nakagawa, Kimitaka Nakazawa

    Neurorehabilitation and Neural Repair   in press  2021.11

    　View Summary

    Background. Drastic functional reorganization was observed in the ipsilateral primary motor cortex (M1) of a Paralympic long jumper with a unilateral below-knee amputation in our previous study. However, it remains unclear whether long-term para-sports are associated with ipsilateral M1 reorganization since only 1 athlete with amputation was investigated. Objective. This study aimed to investigate the relationship between the long-term para-sports and ipsilateral M1 reorganization after lower limb amputation. Methods. Lower limb rhythmic muscle contraction tasks with functional magnetic resonance imaging and T1-weighted structural imaging were performed in 30 lower limb amputees with different para-sports experiences in the chronic phase. Results. Brain activity in the ipsilateral primary motor and somatosensory areas (SM1) as well as the contralateral dorsolateral prefrontal cortex, SM1, and inferior temporal gyrus showed a positive correlation with the years of routine para-sports participation (sports years) during contraction of the amputated knee. Indeed, twelve of the 30 participants who exhibited significant ipsilateral M1 activation during amputated knee contraction had a relatively longer history of para-sports participation. No significant correlation was found in the structural analysis. Conclusions. Long-term para-sports could lead to extensive reorganization at the brain network level, not only bilateral M1 reorganization but also reorganization of the frontal lobe and visual pathways. These results suggest that the interaction of injury-induced and use-dependent cortical plasticity might bring about drastic reorganization in lower limb amputees.

    DOI

  • Dynamic Control of Upper Limb Stretch Reflex in Wrestlers

    Sho Ito, Kento Nakagawa, Tsuyoshi Nakajima, Misaki Iteya, Larry Crawshaw, Kazuyuki Kanosue

    Medicine & Science in Sports & Exercise   Publish Ahead of Print  2021.10

    DOI

  • Intra-limb modulations of posterior root-muscle reflexes evoked from the lower-limb muscles during isometric voluntary contractions

    Akira Saito, Kento Nakagawa, Yohei Masugi, Kimitaka Nakazawa

    Experimental Brain Research   239 ( 10 ) 3035 - 3043  2021.08  [Refereed]

    　View Summary

    <title>Abstract</title>Although voluntary muscle contraction modulates spinal reflex excitability of contracted muscles and other muscles located at other segments within a limb (i.e., intra-limb modulation), to what extent corticospinal pathways are involved in intra-limb modulation of spinal reflex circuits remains unknown. The purpose of the present study was to identify differences in the involvement of corticospinal pathways in intra-limb modulation of spinal reflex circuits among lower-limb muscles during voluntary contractions. Ten young males performed isometric plantar-flexion, dorsi-flexion, knee extension, and knee flexion at 10% of each maximal torque. Electromyographic activity was recorded from soleus, tibialis anterior, vastus lateralis, and biceps femoris muscles. Motor evoked potentials and posterior root-muscle reflexes during rest and isometric contractions were elicited from the lower-limb muscles using transcranial magnetic stimulation and transcutaneous spinal cord stimulation, respectively. Motor evoked potential and posterior root-muscle reflex amplitudes of soleus during knee extension were significantly increased compared to rest. The motor evoked potential amplitude of biceps femoris during dorsi-flexion was significantly increased, whereas the posterior root-muscle reflex amplitude of biceps femoris during dorsi-flexion was significantly decreased compared to rest. These results suggest that corticospinal and spinal reflex excitabilities of soleus are facilitated during knee extension, whereas intra-limb modulation of biceps femoris during dorsi-flexion appeared to be inverse between corticospinal and spinal reflex circuits.

    DOI

  • Increase in foot arch asymmetry after full marathon completion

    Fukano M, Nakagawa K, Inami T, Higashihara A, Iizuka S, Narita T, Maemichi T, Yoshimura A, Yamaguchi S, Iso S

    J Sports Sci   in press  2021.06  [Refereed]

  • Specific Brain Reorganization Underlying Superior Upper Limb Motor Function After Spinal Cord Injury: A Multimodal MRI Study

    Tomoya Nakanishi, Kento Nakagawa, Hirofumi Kobayashi, Kazutoshi Kudo, Kimitaka Nakazawa

    Neurorehabilitation and Neural Repair   35 ( 3 ) 220 - 232  2021.03  [Refereed]

    　View Summary

    <sec><title>Background</title> We recently discovered that individuals with complete spinal cord injury (SCI) have a higher grip force control ability in their intact upper limbs than able-bodied subjects. However, the neural basis for this phenomenon is unknown.

    </sec><sec><title>Objective</title> This study aimed to investigate the neural basis of the higher grip force control in the brains of individuals with SCI using multimodal magnetic resonance imaging (MRI).

    </sec><sec><title>Methods</title> Eight SCI subjects and 10 able-bodied subjects performed hand grip force control tasks at 10%, 20%, and 30% of their maximal voluntary contraction during functional MRI (fMRI). Resting-state fMRI and T1-weighted structural images were obtained to investigate changes in brain networks and structures after SCI.

    </sec><sec><title>Results</title> SCI subjects showed higher grip force steadiness than able-bodied subjects ( P &lt; .05, corrected), smaller activation in the primary motor cortex ( P &lt; .05, corrected), and deactivation of the visual cortex ( P &lt; .001, uncorrected). Furthermore, SCI subjects had stronger functional connectivity between the superior parietal lobule and the left primary motor cortex ( P &lt; .001, uncorrected), as well as larger gray matter volume in the bilateral superior parietal lobule ( P &lt; .001, uncorrected).

    </sec><sec><title>Conclusions</title> The structural and functional reorganization observed in the superior parietal lobule of SCI subjects may represent the neural basis underlying the observed higher grip force control, and is likely responsible for the smaller activation in the primary motor cortex observed in these individuals. These findings could have applications in the fields of neurorehabilitation for improvement of intact limb functions after SCI.

    </sec>

    DOI

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Misc 【 display / non-display 】

  • Neural mechanisms of muscle cramp

    Kento Nakagawa, Naokazu Miyamoto, Kazuyuki Kanosue

    Sports Performance     79 - 90  2015.01

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    Although muscle cramps are a common problem for many athletes, the underlyingmechanisms are still poorly understood. In this chapter, we review the proposed causesof muscle cramps. Dehydration and electrolyte disturbance are generally considered to be causes of muscle cramps, but this is unlikely. Alternatively, either neural activity in the spinal cord or in the peripheral could be the cause of cramps. Definitive evidence is scarce and controversy abounds.

    DOI

  • Remote effect of muscle relaxation

    Kato Kouki, Nakata Hiroki, Nakagawa Kento, Ogawa Tetsuya, Kanosue Kazuyuki

      11   90 - 90  2014

    CiNii

  • Elite dancers have greater auditory-motor synchronization in tapping task

    Kiyota N., Nakagawa K., Kato K., Suwa S., Kanosue K.

      11   95 - 95  2014

    CiNii

  • THE INFLUENCE OF ACTIVATION COUPLING OF CORRESPONDING MUSCLES OF FINGERS AND TOES ON THE STABILITY OF COORDINATED MOVEMENTS

    Tetsuro Muraoka, Masanori Sakamoto, Nobuaki Mizuguchi, Kento Nakagawa, Kazuyuki Kanosue

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   477 - 477  2009

    Research paper, summary (international conference)  

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Research Projects 【 display / non-display 】

  • 力発揮の安定性に関わる中枢神経系機構の特定および機能改善の試み

    Project Year :

    2021.04
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    2023.03
     

    Authorship： Principal investigator

  • アスリートにおける脳の可塑的変化に関わる要因および機能的役割の探索

    若手研究

    Project Year :

    2020.04
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    Authorship： Principal investigator

  • 簡便かつ非侵襲的な神経活動修飾による運動機能改善の試み

    Project Year :

    2017.04
    -
    2020.03
     

    Authorship： Principal investigator

  • 脊髄損傷患者に対する非侵襲的神経機能修飾による姿勢保持能力向上の試み

    Project Year :

    2018.04
    -
    2019.03
     

    Authorship： Principal investigator

  • 筋腹刺激を用いた連合性ペア刺激による脊髄運動ニューロン修飾の試み

    Project Year :

    2018.10
    -
    2019.02
     

    Authorship： Principal investigator

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Specific Research 【 display / non-display 】

  • 過酷な運動による中枢神経系の可塑的変化

    2020  

    　View Summary

    巧緻性を伴う運動スキルトレーニングが中枢神経系の可塑的変化を誘導することが知られているが、巧緻性を伴わない一過性の過酷な運動を行うことによってどのように中枢神経系が可塑的に変化するかは不明である。本研究では、被験者に長時間のランニングを課し、その前後での脳構造変化を検討した。脳構造測定には、MRIを用いて、脳のT1強調画像を取得した。解析では、Voxel-based morphometry (VBM）による局所的な灰白質容量変化を検討した。その結果、運動前に比べて運動後に灰白質量が減少した領域はなかったが、左半球中前頭回のボリュームが増加する傾向にあった（p &lt; 0.001, uncorrected）。今後、さらに頑健な統計処理を実施するため、追加実験を行っていく。

  • アスリートの可塑性における競技特性の検討

    2019  

    　View Summary

    アスリートにおける中枢神経系の可塑的変化を検討するため、二種類の実験を行った。一つは、脊髄反射の可塑的変化を調べるため、脛骨神経への電気刺激によってヒラメ筋からH反射を誘発し、M波最大振幅値に対するH反射最大振幅値を脊髄反射の興奮性の指標として評価した。また、姿勢によるH反射の変動にアスリート特異性が見られるか検討するため、伏臥位と立位の二条件でH反射のリクルートメントカーブを計測した。また、MRIを用いて、アスリートにおける脳の構造、安静時機能ネットワークを計測する実験を行った。今後も研究を継続し、被験者数を増やしたうえで、アスリートにおける特異的な中枢神経系の可塑的変化を明らかにする予定である。

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Syllabus 【 display / non-display 】

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