【目的】高濃度茶カテキン(TCR)継続摂取及びアラニン(Ala)・プロリン(Pro)配合ゼリー飲料単回摂取の併用が全身持久力に与える影響を検討することであった。【方法】運動習慣のある若年成人男性22名を対象に無作為化二重盲検交差試験を用いて全身持久力を評価した。被験者は水500mLの摂取後、1回目のYo-Yo Intermittent Endurance Test Level2(Yo-Yo IE 2)を実施した(水試行)。その後、被験(茶カテキン:540mg)または対照飲料(茶カテキン:0mg)を14日間摂取した。15日目に被験(Ala:9.0g、Pro:1.0g、糖質:82g)または対照ゼリー飲料(糖質:92g)を摂取しYo-Yo IE 2を実施した。14日間のウォッシュアウト後、飲料を替えてYo-Yo IE 2を実施した。【結果】Yo-Yo IE 2の成績は被験飲料、対照飲料試行で水試行より有意な高値を示した(被験飲料試行:p=0.001、d=0.94、対照飲料試行:p=0.001、d=0.93)。水試行のYo-Yo IE 2の成績が2,000m以上の者を対象に層別解析した場合、Yo-Yo IE 2の成績は被験飲料試行で水試行より有意な高値を示した(p=0.028、d=0.90)。Yo-Yo IE 2直後のグルコース濃度は水試行と比較し被験飲料試行で有意な低値を示した(p=0.024、d=0.63)。Yo-Yo IE 2直後のインスリン濃度は被験飲料及び対照飲料試行で水試行と比較し、有意な高値を示した(被験飲料試行:p=0.003、d=0.82、対照飲料試行:p<0.001、d=1.15)。対照飲料試行は被験飲料試行と比較し、高値を示す傾向が認められた(p=0.077)。【結論】TCR継続摂取及びAla・Pro配合ゼリー飲料単回摂取の併用は全身持久力を向上させ、Yo-Yo IE 2の成績が2,000m以上の者への全身持久力向上効果は糖質単回摂取より高い可能性が示唆された。(著者抄録)

Purpose: Although a single bout of continuous exercise (Q30 min) reduces postprandial triglyceride (TG), little evidence is available regarding the effect of multiple short (e10 min) bouts of exercise on postprandial TG in individuals at increased risk for cardiovascular diseases. This study compared the effects of different patterns of walking on postprandial TG in postmenopausal, older women with hypertriglyceridemia. Methods: Twelve inactive women (mean age T SD, 71 T 5 yr) with hypertriglyceridemia (fasting TG Q1.70 mmolILj1) completed three, 1-d laboratory-based trials in a random order: 1) control, 2) continuous walking, and 3) multiple short bouts of walking. On the control trial, participants sat in a chair for 8 h. For the walking trials, participants walked briskly in either one 30-min bout in the morning (0900-0930 h) or twenty 90-s bouts over 8 h. Except for walking, both exercise trials mimicked the control trial. In each trial, participants consumed a standardized breakfast (0800 h) and lunch (1100 h). Venous blood samples were collected in the fasted state and at 2, 4, 6, and 8 h after breakfast. Results: The serum TG incremental area under the curve was 35% and 33% lower on the continuous and multiple short bouts of walking trials than that on the control trial (8.2 T 3.1 vs 8.5 T 5.4 vs 12.7 T 5.8 mmol per 8 hILj1, respectively
main effect of trial: effect size = 0.459, P = 0.001). Conclusions: Accumulating walking in short bouts limits postprandial TG in at-risk, inactive older women with fasting hypertriglyceridemia.

Journal of Endocrinology Acute exercise transiently suppresses the orexigenic gut hormone acylated ghrelin, but the extent to which exercise intensity and duration determine this response is not fully understood. The effects of manipulating exercise intensity and duration on acylated ghrelin concentrations and hunger were examined in two experiments. In experiment one, nine healthy males completed three, 4-h conditions (control, moderate-intensity running (MOD) and vigorous-intensity running (VIG)), with an energy expenditure of similar to 2.5 MJ induced in both MOD (55-min running at 52% peak oxygen uptake (VO2peak)) and VIG (36-min running at 75% VO2peak). In experiment two, nine healthy males completed three, 9-h conditions (control, 45-min running (EX45) and 90-min running (EX90)). Exercise was performed at 70% VO2peak. In both experiments, participants consumed standardised meals, and acylated ghrelin concentrations and hunger were quantified at predetermined intervals. In experiment one, delta acylated ghrelin concentrations were lower than control in MOD (ES = 0.44, P = 0.01) and VIG (ES = 0.98, P &lt; 0.001); VIG was lower than MOD (ES = 0.54, P = 0.003). Hunger ratings were similar across the conditions (P = 0.35). In experiment two, delta acylated ghrelin concentrations were lower than control in EX45 (ES = 0.77, P &lt; 0.001) and EX90 (ES = 0.68, P &lt; 0.001); EX45 and EX90 were similar (ES = 0.09, P = 0.55). Hunger ratings were lower than control in EX45 (ES = 0.20, P = 0.01) and EX90 (ES = 0.27, P = 0.001); EX45 and EX90 were similar (ES = 0.07, P = 0.34). Hunger and delta acylated ghrelin concentrations remained suppressed at 1.5h in EX90 but not EX45. In conclusion, exercise intensity, and to a lesser extent duration, are determinants of the acylated ghrelin response to acute exercise.

<p>This study aimed to examine the effect of different methods of active recovery (AR) after high-intensity exercise on exercise performance, determined with the Yo-Yo Intermittent Recovery Test level 2 (Yo-Yo IR2) in soccer referees. Using a crossover design, fourteen male soccer referees completed three trials. After resting for 10 min, participants ran approximately 495 meters (m) at 80% of maximum heart rate (HRmax) and, ran approximately 165 m at 90% of HRmax. This was followed by 15 min of passive recovery (control), 15 min of running at 130 beats/min (continuous AR), or 15 min of intermittent AR consisting of alternating 2.5 min intervals of passive recovery and running at 130 beats/min, repeated for 15 min (intermittent AR). Finally, participants performed the Yo-Yo IR2. Blood lactate and salivary cortisol concentrations were determined immediately after the rest, high-intensity exercise, recovery intervention and Yo-Yo IR2 periods. The Profile of Mood States (POMS) Questionnaire was measured after rest and Yo-Yo IR2. Yo-Yo IR2 performance was significantly higher in the intermittent AR trial than in the control trial. Blood lactate concentrations were significantly lower in the continuous and intermittent AR trials than in the control trial after the recovery intervention. No significant between-trial differences were observed in salivary cortisol concentrations. The fatigue score using the POMS increased significantly during the control and continuous AR trials, but not during the intermittent AR trial. In conclusion, AR with intermittent exercise after high-intensity exercise increases Yo-Yo IR2 performance compared to passive recovery.</p>

〔目的〕グラウンド・ゴルフ（以下，GG）実施者の移動機能および身体機能を明らかにすることを目的とした．〔対象と方法〕地域在住高齢者508名を対象として，健康調査を実施した．〔結果〕男女ともに対照群（ORs：1.00）と比較してGG実施群は移動機能の低下が始まっている状態を示すロコモ度1に判定されるオッズ比が低く（男性：0.324，女性：0.315），男性において移動機能の低下が進行している状態を示すロコモ度2に判定されるオッズ比も低いことが明らかとなった（0.277）．2ステップテストにおいても対照群と比較してGG実施群が高い値を示した．〔結語〕GG実施者は同年代の高齢者と比較してロコモ度1，2に判定されるリスクが低い．

<p>The purpose of the present study was to examine the associations between physical fitness and body fatness with blood lipid profile in 231 Japanese children and adolescents (12.1 ± 1.5 years). The primary outcomes of the present study were a lipid risk score which was calculated by summing up z scores of three lipid items (triglycerides, low density lipoprotein-cholesterol, and high density lipoprotein-cholesterol). Physical fitness was assessed by using the Japanese standardised fitness test. For body fatness, a percentage of overweight was calculated with using age-, sex-, height-specific standardised body mass. For combined analysis (fitness × fatness), the participants were cross-tabulated into four groups (Non-Obese/Higher-Fit, Non-Obese/Lower-Fit, Obese/Higher-Fit, and Obese/Lower-Fit). The results demonstrated that the participants in fitness categories A/B [most fit] and C [middle] demonstrated the lower (better) lipid risk score than the participants in fitness categories D/E [least fit] (F _{(2, 222)} = 6.03, p = .003). For body fatness, the lipid risk score in obese group was significantly higher (worse) than that in thin and normal groups (F _{(2, 222)} = 6.08, p = .004). The combined analysis showed that there was a significant interaction (fitness × fatness) on the lipid risk score (F _{(1, 221)} = 4.05, p = .047), suggesting that Obese/Lower-Fit group had the worst risk score compared to the other groups. The present study suggests that improving both fitness and body fatness might be important for better lipid profile in Japanese children and adolescents.</p>

The present study examined the sex-specific associations of moderate and vigorous physical activity (VPA) with physical fitness in 300 Japanese adolescents aged 12–14 years. Participants were asked to wear an accelerometer to evaluate physical activity (PA) levels of various intensities (i.e. moderate PA (MPA), 3–5.9 metabolic equivalents (METs)
VPA, ≥6 METs
moderate to vigorous PA (MVPA), ≥3 METs). Eight fitness items were assessed (grip strength, bent-leg sit-up, sit-and-reach, side step, 50 m sprint, standing long jump, handball throw, and distance running) as part of the Japanese standardised fitness test. A fitness composite score was calculated using Japanese fitness norms, and participants were categorised according to their score from category A (most fit) to category E (least fit), with participants in categories D and E defined as having low fitness. It was found that for boys, accumulating more than 80.7 min/day of MVPA may reduce the probability of low fitness (odds ratio (ORs) [95% confidence interval (CI)] = 0.17 [0.06–0.47], p =.001). For girls, accumulating only 8.4 min of VPA could reduce the likelihood of exhibiting low fitness (ORs [95% CI] = 0.23 [0.05–0.89], p =.032). These results reveal that there are sex-specific differences in the relationship between PA and physical fitness in adolescents, suggesting that sex-specific PA recommendation may be needed to improve physical fitness in adolescents.

The present study examined the sex-specific associations of moderate and vigorous physical activity (VPA) with physical fitness in 300 Japanese adolescents aged 12-14 years. Participants were asked to wear an accelerometer to evaluate physical activity (PA) levels of various intensities (i.e. moderate PA (MPA), 3-5.9 metabolic equivalents (METs); VPA, 6 METs; moderate to vigorous PA (MVPA), 3 METs). Eight fitness items were assessed (grip strength, bent-leg sit-up, sit-and-reach, side step, 50m sprint, standing long jump, handball throw, and distance running) as part of the Japanese standardised fitness test. A fitness composite score was calculated using Japanese fitness norms, and participants were categorised according to their score from category A (most fit) to category E (least fit), with participants in categories D and E defined as having low fitness. It was found that for boys, accumulating more than 80.7min/day of MVPA may reduce the probability of low fitness (odds ratio (ORs) [95% confidence interval (CI)]=0.17 [0.06-0.47], p=.001). For girls, accumulating only 8.4min of VPA could reduce the likelihood of exhibiting low fitness (ORs [95% CI]=0.23 [0.05-0.89], p=.032). These results reveal that there are sex-specific differences in the relationship between PA and physical fitness in adolescents, suggesting that sex-specific PA recommendation may be needed to improve physical fitness in adolescents.

© 2016 European College of Sport ScienceThe present study examined the sex-specific associations of moderate and vigorous physical activity (VPA) with physical fitness in 300 Japanese adolescents aged 12–14 years. Participants were asked to wear an accelerometer to evaluate physical activity (PA) levels of various intensities (i.e. moderate PA (MPA), 3–5.9 metabolic equivalents (METs); VPA, ≥6 METs; moderate to vigorous PA (MVPA), ≥3 METs). Eight fitness items were assessed (grip strength, bent-leg sit-up, sit-and-reach, side step, 50 m sprint, standing long jump, handball throw, and distance running) as part of the Japanese standardised fitness test. A fitness composite score was calculated using Japanese fitness norms, and participants were categorised according to their score from category A (most fit) to category E (least fit), with participants in categories D and E defined as having low fitness. It was found that for boys, accumulating more than 80.7 min/day of MVPA may reduce the probability of low fitness (odds ratio (ORs) [95% confidence interval (CI)] = 0.17 [0.06–0.47], p = .001). For girls, accumulating only 8.4 min of VPA could reduce the likelihood of exhibiting low fitness (ORs [95% CI] = 0.23 [0.05–0.89], p = .032). These results reveal that there are sex-specific differences in the relationship between PA and physical fitness in adolescents, suggesting that sex-specific PA recommendation may be needed to improve physical fitness in adolescents.

We compared the effects of prolonged sitting with the effects of sitting interrupted by regular walking and the effects of prolonged sitting after continuous walking on postprandial triglyceride in postmenopausal women. 15 participants completed 3 trials in random order: 1) prolonged sitting, 2) regular walking, and 3) prolonged sitting preceded by continuous walking. During the sitting trial, participants rested for 8h. For the walking trials, participants walked briskly in either twenty 90-sec bouts over 8h or one 30-min bout in the morning (09:00-09:30). Except for walking, both exercise trials mimicked the sitting trial. In each trial, participants consumed a breakfast (08:00) and lunch (11:00). Blood samples were collected in the fasted state and at 2, 4, 6 and 8h after breakfast. The serum triglyceride incremental area under the curve was 15 and 14% lower after regular walking compared with prolonged sitting and prolonged sitting after continuous walking (4.73 +/- 2.50 vs. 5.52 +/- 2.95 vs. 5.50 +/- 2.59mmol/L.8h respectively, main effect of trial: P=0.023). Regularly interrupting sitting time with brief bouts of physical activity can reduce postprandial triglyceride in postmenopausal women.

Energy balance plays an important role in weight control. Ghrelin is known to stimulate food intake, while peptide YY (PYY) and glucagon-like peptide (GLP-1) are known to suppress food intake. These appetite-related hormones are affected by behaviours such as exercise and mastication. Increasing the number of times food is chewed during a standard meal suppresses ghrelin secretion and food intake. The intensity of exercise is more strongly related to the secretion of total ghrelin, acylated ghrelin, PYY3-36 and food intake than the duration or mode of exercise. This review summarises the effects of exercise and mastication on appetite-related hormones and/or energy intake.

Energy balance plays an important role in weight control. Ghrelin is known to stimulate food intake, while peptide YY (PYY) and glucagon-like peptide (GLP-1) are known to suppress food intake. These appetite-related hormones are affected by behaviours such as exercise and mastication. Increasing the number of times food is chewed during a standard meal suppresses ghrelin secretion and food intake. The intensity of exercise is more strongly related to the secretion of total ghrelin, acylated ghrelin, PYY3-36 and food intake than the duration or mode of exercise. This review summarises the effects of exercise and mastication on appetiterelated hormones and/or energy intake.

We compared the effects of prolonged sitting with the effects of sitting interrupted by regular walking and the effects of prolonged sitting after continuous walking on postprandial triglyceride in postmenopausal women. 15 participants completed 3 trials in random order: 1) prolonged sitting, 2) regular walking, and 3) prolonged sitting preceded by continuous walking. During the sitting trial, participants rested for 8 h. For the walking trials, participants walked briskly in either twenty 90-sec bouts over 8 h or one 30-min bout in the morning (09:00-09:30). Except for walking, both exercise trials mimicked the sitting trial. In each trial, participants consumed a breakfast (08:00) and lunch (11:00). Blood samples were collected in the fasted state and at 2, 4, 6 and 8 h after breakfast. The serum triglyceride incremental area under the curve was 15 and 14% lower after regular walking compared with prolonged sitting and prolonged sitting after continuous walking (4.73±2.50 vs. 5.52±2.95 vs. 5.50±2.59 mmol/La·8 h respectively, main effect of trial: P=0.023). Regularly interrupting sitting time with brief bouts of physical activity can reduce postprandial triglyceride in postmenopausal women.

Background: Sedentary behavior, which includes sitting and TV viewing, has been identified as an independent risk factor for type 2 diabetes and cardiovascular disease. Breaking sedentary behavior improves metabolic health such as postprandial glycaemia and insulinemia. However, the mechanisms underlying this effect are unclear. Objectives: Here, we examined whether breaking sitting by standing and acute exercise reduces postprandial oxidative stress. Patient and Methods: Fifteen participants performed 3 trials (sitting, standing, and exercise), each lasting 2 days, in a randomised order. On day one of sitting trial, participants sat in a chair. For the standing trial, the participants stood 6 times, for a 45-minute period each time. For the exercise trial, the participants walked or ran at approximately 60% of age-predicted maximum heart rate for 30 minutes. On day two of each trial, participants rested and consumed the standardised breakfast and lunch. Blood samples were collected in the morning and afternoon on day one, and fasting and at 2, 4, and 6 hours postprandially on day two. Results: The concentrations of serum derivatives of reactive oxygen metabolites (d-ROMs) measured at 4 hours (P = 0.064) and 6 hours (P = 0.071) tended to be higher than that in the fasting state in the sitting trial, but not standing and exercise trial (two-factor analysis of variance (ANOVA), trial × time interaction, P = 0.006). Conclusions: Our results indicate the importance of reducing sitting time for improving postprandial oxidative stress status.

Background: Sedentary behavior, which includes sitting and TV viewing, has been identified as an independent risk factor for type 2 diabetes and cardiovascular disease. Breaking sedentary behavior improves metabolic health such as postprandial glycaemia and insulinemia. However, the mechanisms underlying this effect are unclear. Objectives: Here, we examined whether breaking sitting by standing and acute exercise reduces postprandial oxidative stress. Patient and Methods: Fifteen participants performed 3 trials (sitting, standing, and exercise), each lasting 2 days, in a randomised order. On day one of sitting trial, participants sat in a chair. For the standing trial, the participants stood 6 times, for a 45-minute period each time. For the exercise trial, the participants walked or ran at approximately 60% of age-predicted maximum heart rate for 30 minutes. On day two of each trial, participants rested and consumed the standardised breakfast and lunch. Blood samples were collected in the morning and afternoon on day one, and fasting and at 2, 4, and 6 hours postprandially on day two. Results: The concentrations of serum derivatives of reactive oxygen metabolites (d-ROMs) measured at 4 hours (P = 0.064) and 6 hours (P = 0.071) tended to be higher than that in the fasting state in the sitting trial, but not standing and exercise trial (two-factor analysis of variance (ANOVA), trial × time interaction, P = 0.006). Conclusions: Our results indicate the importance of reducing sitting time for improving postprandial oxidative stress status.

This review examined if high-intensity interval exercise (HIIE) reduces postprandial triacylglycerol (TAG) levels. Fifteen studies were identified, in which the effect of interval exercise conducted at an intensity of &gt;65 % of maximal oxygen uptake was evaluated on postprandial TAG levels. Analysis was divided between studies that included supramaximal exercise and those that included submaximal interval exercise. Ten studies examined the effect of a single session of low-volume HIIE including supramaximal sprints on postprandial TAG. Seven of these studies noted reductions in the postprandial total TAG area under the curve the morning after exercise of between similar to 10 and 21 % compared with rest, but three investigations found no significant difference in TAG levels. Variations in the HIIE protocol used, inter-individual variation or insufficient time post-exercise for an increase in lipoprotein lipase activity are proposed reasons for the divergent results among studies. Five studies examined the effect of high-volume submaximal interval exercise on postprandial TAG. Four of these studies were characterised by high exercise energy expenditure and effectively attenuated total postprandial TAG levels by similar to 15-30 %, but one study with a lower energy expenditure found no effect on TAG. The evidence suggests that supramaximal HIIE can induce large reductions in postprandial TAG levels but findings are inconsistent. Submaximal interval exercise offers no TAG metabolic or time advantage over continuous aerobic exercise but could be appealing in nature to some individuals. Future research should examine if submaximal interval exercise can reduce TAG levels in line with more realistic and achievable exercise durations of 30 min per day.

Limited evidence was available to support the effect of self-selected activities performed under free-living conditions on postprandial lipaemia, particularly for older adults. Thus, the aim of the present study was to examine the chronic effect of increased physical activity of daily living on postprandial triacylglycerol (TAG) in postmenopausal women. Twenty-eight postmenopausal women, aged 71 ± 4 years (mean ± SD), were randomly divided into two groups: active (n=14) and control (n=14) groups. The participants in the active group were asked to increase their activities above their usual lifestyle levels for 4 weeks; freely deciding the duration and intensity of their chosen activities. The participants in the control group maintained their usual lifestyle for 4 weeks. All participants were asked to wear a uniaxial accelerometer for 4 consecutive weeks. At baseline and after 4 weeks, all participants rested and consumed a standardised breakfast and lunch after a 24-h period of physical activity avoidance. Blood samples were collected in the fasted state (0 h) and at 2, 4 and 6 h after breakfast. After 4 weeks, the participants in the active group increased their step counts by 600 steps/day (from 6979 ± 2057 to 7586 ± 2301 steps/day, p=0.047). There was no difference in the pattern of postprandial TAG response between groups (trial × time interaction, p=0.335). A previous study has suggested that only recent exercise (i.e., 12h before but not 24 h before) appears to facilitate the exercise-induced postprandial TAG lowering effects. Thus, in the present study, postprandial lipaemia was not reduced after performing self-selected activities under free-living in postmenopausal women.

Oxidative stress and inflammatory conditions are associated with an increased risk of atherosclerosis and cardiovascular disease. A large body of evidence supports the notion that higher intensity and/or longer duration exercise training can reduce many cardiovascular disease risk factors including oxidative stress and oxidised low-density lipoprotein. Although physical activity guidelines suggest that adults should engage in at least 150 min of physical activity each week, estimates in many countries suggest that many individuals do not exercise adequately as per guidelines. It is important to determine the minimum level of physical activity required to reduce the risks of cardiovascular disease and atherosclerosis. Thus, the authors conducted a series of investigations to examine the influence of daily physical activity or low-volume exercise training on cardiovascular disease risk factors including oxidative stress markers and oxidised low-density lipoprotein concentration in older adults. We demonstrate that daily physical activity and a low-volume walking program (&lt
150 min/week) improved oxidative stress status in older adults. The implications of the research findings may encourage more people to incorporate a small amount of physical activity into their lives, and translate to prevention of cardiovascular disease and atherosclerosis in the long term.

Limited evidence was available to support the effect of self-selected activities performed under free-living conditions on postprandial lipaemia, particularly for older adults. Thus, the aim of the present study was to examine the chronic effect of increased physical activity of daily living on postprandial triacylglycerol (TAG) in postmenopausal women. Twentyeight postmenopausal women, aged 71 ± 4 years (mean ± SD), were randomly divided into two groups: active (n=14) and control (n=14) groups. The participants in the active group were asked to increase their activities above their usual lifestyle levels for 4 weeks
freely deciding the duration and intensity of their chosen activities. The participants in the control group maintained their usual lifestyle for 4 weeks. All participants were asked to wear a uniaxial accelerometer for 4 consecutive weeks. At baseline and after 4 weeks, all participants rested and consumed a standardised breakfast and lunch after a 24-h period of physical activity avoidance. Blood samples were collected in the fasted state (0 h) and at 2, 4 and 6 h after breakfast. After 4 weeks, the participants in the active group increased their step counts by 600 steps/day (from 6979 ± 2057 to 7586 ± 2301 steps/day, p=0.047). There was no difference in the pattern of postprandial TAG response between groups (trial × time interaction, p=0.335). A previous study has suggested that only recent exercise (i.e., 12h before but not 24 h before) appears to facilitate the exercise-induced postprandial TAG lowering effects. Thus, in the present study, postprandial lipaemia was not reduced after performing self-selected activities under free-living in postmenopausal women.

This study examined the acute effect of increased participation in weekend physical activity on postprandial lipemia in postmenopausal women. Ten postmenopausal women, aged 63 +/- 4 years (mean +/- SD), completed 2 trials in a random order: 1) control trial and 2) active trial. In the control trial, participants maintained their usual weekend lifestyle. In the active trial, participants increased their weekend activities above their usual lifestyle levels, freely deciding the duration and intensity of their chosen activities. On Monday of each trial, participants rested and consumed a standardised breakfast and lunch. Capillary blood samples were collected in the fasted state (0h) and at 2, 4 and 6h after eating. In the active trial, participants increased their moderate to vigorous weekend physical activity by 16min (mean +/- SD: 12.3 +/- 6.7min vs. 27.9 +/- 11.9min, P=0.009). Area under the capillary triacylglycerol concentration vs. time curve was 13% lower in the active trial than control trial (8.8 +/- 3.8 vs. 10.1 +/- 3.9mmol/L.6h, P=0.024). These findings demonstrate that small increases in moderate to vigorous physical activity under a real-life setting lowers postprandial lipemia in postmenopausal women.

Elevated postprandial hyperglycaemia and oxidative stress increase the risks of type 2 diabetes and CVD. Green tea catechin possesses antidiabetic properties and antioxidant capacity. In the present study, we examined the acute and continuous effects of ingestion of catechin-rich green tea on postprandial hyperglycaemia and oxidative stress in healthy postmenopausal women. Participants were randomly assigned into the placebo (P, n 11) or green tea (GT, n 11) group. The GT group consumed a catechin-rich green tea (catechins 615 mg/350 ml) beverage per d for 4 weeks. The P group consumed a placebo (catechins 92 mg/350 ml) beverage per d for 4 weeks. At baseline and after 4 weeks, participants of each group consumed their designated beverages with breakfast and consumed lunch 3 h after breakfast. Venous blood samples were collected in the fasted state (0 h) and at 2, 4 and 6 h after breakfast. Postprandial glucose concentrations were 3 % lower in the GT group than in the P group (three-factor ANOVA, group × time interaction, P&lt
0·05). Serum concentrations of the derivatives of reactive oxygen metabolites increased after meals (P&lt
0·05), but no effect of catechin-rich green tea intake was observed. Conversely, serum postprandial thioredoxin concentrations were 5 % higher in the GT group than in the P group (three-factor ANOVA, group × time interaction, P&lt
0·05). These findings indicate that an acute ingestion of catechin-rich green tea has beneficial effects on postprandial glucose and redox homeostasis in postmenopausal women.

Elevated postprandial hyperglycaemia and oxidative stress increase the risks of type 2 diabetes and CVD. Green tea catechin possesses antidiabetic properties and antioxidant capacity. In the present study, we examined the acute and continuous effects of ingestion of catechin-rich green tea on postprandial hyperglycaemia and oxidative stress in healthy postmenopausal women. Participants were randomly assigned into the placebo (P, n 11) or green tea (GT, n 11) group. The GT group consumed a catechin-rich green tea (catechins 615 mg/350 ml) beverage per d for 4 weeks. The P group consumed a placebo (catechins 92 mg/350 ml) beverage per d for 4 weeks. At baseline and after 4 weeks, participants of each group consumed their designated beverages with breakfast and consumed lunch 3 h after breakfast. Venous blood samples were collected in the fasted state (0 h) and at 2, 4 and 6 h after breakfast. Postprandial glucose concentrations were 3% lower in the GT group than in the P group (three-factor ANOVA, group x time interaction, P&lt;0.05). Serum concentrations of the derivatives of reactive oxygen metabolites increased after meals (P&lt;0.05), but no effect of catechin-rich green tea intake was observed. Conversely, serum postprandial thioredoxin concentrations were 5% higher in the GT group than in the P group (three-factor ANOVA, group x time interaction, P&lt;0.05). These findings indicate that an acute ingestion of catechin-rich green tea has beneficial effects on postprandial glucose and redox homeostasis in postmenopausal women.

This study examined the acute effect of increased participation in weekend physical activity on postprandial lipemia in postmenopausal women. Ten postmenopausal women, aged 63±4 years (mean±SD), completed 2 trials in a random order: 1) control trial and 2) active trial. In the control trial, participants maintained their usual weekend lifestyle. In the active trial, participants increased their weekend activities above their usual lifestyle levels, freely deciding the duration and intensity of their chosen activities. On Monday of each trial, participants rested and consumed a standardised breakfast and lunch. Capillary blood samples were collected in the fasted state (0 h) and at 2, 4 and 6 h after eating. In the active trial, participants increased their moderate to vigorous weekend physical activity by 16 min (mean±SD: 12.3±6.7 min vs. 27.9±11.9 min, P=0.009). Area under the capillary triacylglycerol concentration vs. time curve was 13% lower in the active trial than control trial (8.8±3.8 vs. 10.1±3.9 mmol/L 6 h, P=0.024). These findings demonstrate that small increases in moderate to vigorous physical activity under a real-life setting lowers postprandial lipemia in postmenopausal women.

The purpose of this study was to investigate the effects of curcumin supplementation on exercise-induced oxidative stress in humans. 10 male participants, ages 26.8 +/- 2.0 years (mean +/- SE), completed 3 trials in a random order: (1) placebo (control), (2) single (only before exercise) and (3) double (before and immediately after exercise) curcumin supplementation trials. Each participant received oral administration of 90 mg of curcumin or the placebo 2 h before exercise and immediately after exercise. Each participant walked or ran at 65 % of (V) over dotO(2max) on a treadmill for 60 min. Blood samples were collected pre-exercise, immediately after exercise and 2 h after exercise. The concentrations of serum derivatives of reactive oxygen metabolites measured immediately after exercise were significantly higher than pre-exercise values in the placebo trial (308.8 +/- 12.9 U. CARR, P &lt; 0.05), but not in the single (259.9 +/- 17.1 U. CARR) or double (273.6 +/- 19.7 U. CARR) curcumin supplementation trials. Serum biological antioxidant potential concentrations measured immediately after exercise were significantly elevated in the single and double curcumin supplementation trials compared with pre-exercise values (P &lt; 0.05). These findings indicate that curcumin supplementation can attenuate exercise-induced oxidative stress by increasing blood antioxidant capacity.

:Although numerous sources of evidence show that regular physical activity is beneficial to health, most individuals do not engage in a sufficient amount of physical activity to meet the guidelines set out by expert panels. In addition, the minimum amount of physical activity associated with reduced cardiovascular disease risk markers is not clear in older adults. The purpose of this study was to determine the effects of a 12-week walking program involving an exercise volume below the current minimum physical activity recommendation on cardiovascular disease risk markers in older adults. The participants were recruited from the following two groups separately: a walking group (n = 14) and a control group (n = 14). In the walking group, participants walked 30 to 60 minutes per session on 2 days per week for 12 weeks (average walking time, 49.4 ± 8.8 min/session). Plasma oxidised low-density lipoprotein concentrations tended to be lower than baseline values in the walking group after 12 weeks (paired t-test, p = 0.127). The ratio of oxidised low-density lipoprotein to high-density lipoprotein cholesterol was significantly lower than the baseline ratio in the walking group after 12 w

:The purpose of this study was to investigate the effects of curcumin supplementation on exercise-induced oxidative stress in humans. 10 male participants, ages 26.8±2.0 years (mean±SE), completed 3 trials in a random order: (1) placebo (control), (2) single (only before exercise) and (3) double (before and immediately after exercise) curcumin supplementation trials. Each participant received oral administration of 90 mg of curcumin or the placebo 2h before exercise and immediately after exercise. Each participant walked or ran at 65% of V˙2max on a treadmill for 60min. Blood samples were collected pre-exercise, immediately after exercise and 2h after exercise. The concentrations of serum derivatives of reactive oxygen metabolites measured immediately after exercise were significantly higher than pre-exercise values in the placebo trial (308.8±12.9 U. CARR, P<0.05), but not in the single (259.9±17.1 U. CARR) or double (273.6±19.7 U. CARR) curcumin supplementation trials. Serum biological antioxidant potential concentrations measured immediately after exercise were significantly elevated in the single and double curcumin supplementation trials compared with pre-exercise values (P<0.05). These findings indicate that curcumin supplementation can attenuate exercise-induced oxidative stress by increasing blood antioxidant capacity.

:Although numerous sources of evidence show that regular physical activity is beneficial to health, most individuals do not engage in a sufficient amount of physical activity to meet the guidelines set out by expert panels. In addition, the minimum amount of physical activity associated with reduced cardiovascular disease risk markers is not clear in older adults. The purpose of this study was to determine the effects of a 12-week walking program involving an exercise volume below the current minimum physical activity recommendation on cardiovascular disease risk markers in older adults. The participants were recruited from the following two groups separately: a walking group (n = 14) and a control group (n = 14). In the walking group, participants walked 30 to 60 minutes per session on 2 days per week for 12 weeks (average walking time, 49.4 ± 8.8 min/session). Plasma oxidised low-density lipoprotein concentrations tended to be lower than baseline values in the walking group after 12 weeks (paired t-test, p = 0.127). The ratio of oxidised low-density lipoprotein to high-density lipoprotein cholesterol was significantly lower than the baseline ratio in the walking group after 12 weeks (paired t-test, p = 0.035). Resting systolic blood pressure and diastolic blood pressure were significantly lower than baseline values in the walking group after 12 weeks (paired t-tests, p = 0.002, p < 0.0005, respectively). Our findings demonstrate that a 12-week walking program comprising a low volume of physical activity confers a benefit to cardiovascular-related health in older adults. Key PointsIt is important to consider baseline physical activity levels when evaluating physical activity program.Being physically active is important to reduce the potential risk marker of cardiovascular disease in older adults.These data imply that a small volume of 12-week walking program confers a benefit to cardiovascular-related health in older adults.

This study examined associations between four health-related physical fitness measures and obesity in Taiwanese youth aged 10-18 years. Data from 13,500 school-aged youth were randomly selected from the "School Physical Fitness Database" of Taiwan by sex and age. Variables examined were height, body mass and performance on modified sit-and-reach (flexibility), bent-leg sit-up (abdominal muscular strength/endurance), standing long jump (lower body explosive strength) and distance run/walk (cardiorespiratory endurance). Adjusted logistic regression analyses were performed. Increased odds of being obese with decreased fitness levels were observed for lower body explosive strength and cardiorespiratory endurance in both sexes. The highest odds of being obese was found in the least fit quintile of cardiorespiratory endurance compared with the most fit quintile both in boys (Odds ratio, OR = 10.44
95% confidence interval (CI), 7.94-13.73) and girls (OR = 5.40
95% CI, 3.90-7.47). These findings suggest that in addition to cardiorespiratory fitness, lower body explosive strength is also associated with childhood and adolescent obesity. © 2013 Taylor &amp
Francis.

This study examined associations between four health-related physical fitness measures and obesity in Taiwanese youth aged 10-18 years. Data from 13,500 school-aged youth were randomly selected from the School Physical Fitness Database of Taiwan by sex and age. Variables examined were height, body mass and performance on modified sit-and-reach (flexibility), bent-leg sit-up (abdominal muscular strength/endurance), standing long jump (lower body explosive strength) and distance run/walk (cardiorespiratory endurance). Adjusted logistic regression analyses were performed. Increased odds of being obese with decreased fitness levels were observed for lower body explosive strength and cardiorespiratory endurance in both sexes. The highest odds of being obese was found in the least fit quintile of cardiorespiratory endurance compared with the most fit quintile both in boys (Odds ratio, OR=10.44; 95% confidence interval (CI), 7.94-13.73) and girls (OR=5.40; 95% CI, 3.90-7.47). These findings suggest that in addition to cardiorespiratory fitness, lower body explosive strength is also associated with childhood and adolescent obesity.

The purpose of this study was to investigate the effects of low-volume exercise training (90 min/wk) and vitamin E supplementation on oxidative stress markers in postmenopausal women. The participants were non-randomly assigned the following four groups: control (C, n=8), vitamin E (S, n=8), exercise (Ex, n=6), or vitamin E and exercise (S+Ex, n=7). The S and S+Ex groups were instructed to take vitamin E (alpha-tocopherol, 300 mg/d) capsules for 12 wk. The exercise program of Ex and S+Ex groups consisted of walking for a 30-60 min/session 2 d per week for 12 wk. The serum derivatives of reactive oxygen metabolites concentrations were significantly decreased in the Ex, and S+Ex groups after 12 wk compared with the baseline values (three-factor ANOVA, an interaction between exercise and time, p&lt;0.05). Conversely, serum biological antioxidant potential concentrations in the S and Ex groups were significantly higher at 12 wk than at the baseline, but not in the S+Ex group (three-factor ANOVA, an interaction between supplementation, exercise and time, p&lt;0.05). Plasma thioredoxin concentrations in the S, Ex, and S+Ex groups were significantly higher at 12 wk than at the baseline values (three-factor ANOVA, interactions between exercise and time, and between supplementation, exercise and time, p&lt;0.05). Our findings suggest that low-volume physical activity may improve resting oxidative stress status in postmenopausal women.

Oxidative stress increases with advancing age and is a mediator of several diseases including cancer, cardiovascular disease, and diabetes. Moreover, postmenopausal women have a lower estrogen concentration, which is associated with elevated oxidative stress. However, there is no definitive evidence regarding the relationship between daily physical activity and oxidative stress status in older adults, including postmenopausal women. Twenty- nine adults (age, 70.1 ± 1.0 years, mean ± SE; 12 women and 17 men) were examined in this cross-sectional study. Prior to blood collection, the participants were asked to wear a uniaxial accelerometer for 4 consecutive weeks to determine their level of physical activity. After a 48-h period of physical activity avoidance and a 10-h overnight fast, venous blood samples were obtained from each participant. Fasting plasma derivatives of reactive oxygen metabolites (d-ROMs) and malondialdehyde (MDA) concentrations of oxidative stress markers were negatively correlated with the amount of physical activity in women (d-ROMs; r = -0.708, p = 0.002) (MDA; r = -0.549, p = 0.028), but not in men. Fasting plasma biological antioxidant potential of antioxidant capacity marker was positively correlated with the amount of physical activity in women (BAP; r = 0.657, p = 0.006) (GSH; r = 0.549, p = 0.028), but not in men. Moreover, superoxide dismutase activity of antioxidant capacity marker was positively correlated with the amount of physical activity in men (r = 0.627, p = 0.039), but not in women. There were no associations between physical activity and other oxidative stress markers (reduced and oxidized glutathione, glutathione peroxidise, thioredoxin). These findings suggest that regular physical activity may have a protective effect against oxidative stress by increasing total antioxidant capacity, especially in postmenopausal women. © Journal of Sports Science and Medicine.

PURPOSE: We examined whether continuous and intermittent physical activity (PA) differentially influence fat utilization. METHODS: This was a randomized crossover study. Nine healthy young male participants performed two 39-h (two nights, three days) PA sessions (continuous and intermittent exercise) in a respiratory chamber to measure energy expenditure (EE) and substrate oxidation. Participants used a stationary cycling ergometer continuously for 40 min and then 45 min in the continuous PA trial and for 5 min every 30 min 17 times in the intermittent PA trial. They consumed high-carbohydrate meals corresponding to predicted daily total EE for 3 d before entering the respiratory chamber and four high-fat meals corresponding to predicted total EE in the chamber. RESULTS: Twenty-three-hour RER adjusted for sleeping RER on the preceding day was significantly lower in the intermittent PA trial than that in the continuous PA trial (P = 0.021). Twenty-three-hour RER adjusted for sleeping RER on the preceding day was correlated with accumulated consecutive minutes of METs ≤ 1.5 (3 min or more, r = 0.477; 5 min or more, r = 0.510; 10 min or more, r = 0.605). CONCLUSIONS: The intermittent PA trial induced greater fat utilization than the continuous PA trial. The present study, therefore, suggests that intermittent PA has a beneficial effect on 24-h fat oxidation after consumption of a high-fat meal, which may help prevent weight gain over time.

Purpose: We examined whether continuous and intermittent physical activity (PA) differentially influence fat utilization. Methods: This was a randomized crossover study. Nine healthy young male participants performed two 39-h (two nights, three days) PA sessions (continuous and intermittent exercise) in a respiratory chamber to measure energy expenditure (EE) and substrate oxidation. Participants used a stationary cycling ergometer continuously for 40 min and then 45 min in the continuous PA trial and for 5 min every 30 min 17 times in the intermittent PA trial. They consumed high-carbohydrate meals corresponding to predicted daily total EE for 3 d before entering the respiratory chamber and four high-fat meals corresponding to predicted total EE in the chamber. Results: Twenty-three-hour RER adjusted for sleeping RER on the preceding day was significantly lower in the intermittent PA trial than that in the continuous PA trial (P = 0.021). Twenty-three-hour RER adjusted for sleeping RER on the preceding day was correlated with accumulated consecutive minutes of METs &lt;= 1.5 (3 min or more, r = 0.477; 5 min or more, r = 0.510; 10 min or more, r = 0.605). Conclusions: The intermittent PA trial induced greater fat utilization than the continuous PA trial. The present study, therefore, suggests that intermittent PA has a beneficial effect on 24-h fat oxidation after consumption of a high-fat meal, which may help prevent weight gain over time.

The present study determined the changes in appetite and appetite-regulating gut hormones during and following bouts of both rope skipping exercise (weight-bearing) and bicycle ergometer exercise (non-weight-bearing). After a 12-h fast, 15 young men (mean ± SD, age 24.4 ± 1.7. yrs, maximal oxygen uptake 47.0 ± 6.5. mL/kg/min) participated in three 160. min trials: (1) rope skipping exercise (295 ± 40. kcal, 3 sets × 10. min with 5-min interval, then rested for 120. min)
(2) bicycle ergometer exercise (288 ± 36. kcal, 3 sets × 10. min with 5-min interval, then rested for 120. min)
(3) control (rested for 160. min). Ratings of perceived hunger and acylated ghrelin were suppressed and total peptide YY (PYY) were increased during and immediately after exercise in both exercise trials, but glucagon liked peptide-1 was not changed. Furthermore, suppressed hunger during rope skipping exercise was greater than that during bicycle ergometer exercise, but there were no differences in acylated ghrelin and total PYY. These results indicate that weight-bearing exercise has a greater exercise-induced appetite suppressive effect compared with non-weight-bearing exercise, and both forms of exercise lowered acylated ghrelin and increased total PYY, but the changes did not differ significantly between exercise modes. © 2013 Elsevier Ltd.

Background: Both exercise and vitamin E supplementation have been shown to reduce oxidative stress and cardiovascular disease risk in older adults, and when combined there is evidence suggesting that they act synergistically. The currently recommended amount of exercise for older adults is 150 min/week of moderate-intensity exercise; however, the minimum amount of exercise necessary to achieve health benefits is not known. The purpose of this study was to investigate the effects of 12 weeks of participation in a low-volume walking exercise programme (i.e. 90 min/week) combined with daily vitamin E supplementation on thiobarbituric acid reactive substances (TBARS) and oxidised low-density lipoprotein (LDL) concentrations in older adults.
Methods: The participants were recruited from the following four groups separately: 1) control (CG, n = 14), 2) vitamin E supplementation (SG, n = 10), 3) walking (WG, n = 7), or 4) walking + supplementation (WSG, n = 7). In the CG, participants were advised to maintain their normal lifestyle during the study. Participants in both the SG and WSG received 450 IU (300 mg) /day of a-tocopherol for 12 weeks. The exercise programme for the WG and WSG consisted of two 30-60 minute sessions weekly for 12 weeks (average walking time was 44.5 +/- 1.6 min/session). Blood samples were collected at baseline and at 12 weeks.
Results: Delta plasma oxidised LDL concentrations did not differ among four groups (One-factor ANOVA, P = 0.116). However, negative delta plasma TBARS, a marker of oxidative damage, concentrations were observed in the WG, WSG and SG relative to the CG at the end of the study period (One-factor ANOVA, P = 0.001; post hoc tests; CG compared with WG, WSG and SG, P = 0.005; P = 0.021; P = 0.024, respectively).
Conclusion: These findings suggest that a low-volume of physical activity and/or vitamin E supplementation may be an effective intervention strategy for reducing TBARS concentrations of older adults.
Trial registration: UMIN000008304

The purpose of this study was to investigate the effects of low-volume exercise training (100 min/week) on oxidative stress and neutrophils activation markers in older adults. Twenty-eight older adults (age range 65-78 years) were assigned into control (n = 14) or exercise (n = 14) groups. The exercise program consisted of walking 30-60 min/session, 2 days each week for 12 weeks. Blood samples were taken before starting the sessions (baseline) and when they ended. Fasting plasma and serum oxidative stress and inflammatory markers were measured using commercial kits. Cell surface expression of adhesion molecules on circulating leukocytes (CD66b and CD62L) was determined using flow cytometry. The concentrations of derivatives of reactive oxygen metabolites tended to be lower than the baseline values only in the exercise group (P = 0.05). The biological antioxidant potential, thioredoxin concentrations, and glutathione peroxidase activities significantly increased only in the exercise group (P < 0.05 for all). While CD66b expression tended to decrease only in the exercise group, CD62L expression significantly increased (P < 0.05). Our findings indicate that exercise training below the current recommended level of at least 150 min/week attenuates basal oxidative stress and neutrophil activation in older adults. Thus, our findings may encourage more people to incorporate a small amount of physical activity into their lives.

Background: Both exercise and vitamin E supplementation have been shown to reduce oxidative stress and cardiovascular disease risk in older adults, and when combined there is evidence suggesting that they act synergistically. The currently recommended amount of exercise for older adults is 150 min/week of moderate-intensity exercise; however, the minimum amount of exercise necessary to achieve health benefits is not known. The purpose of this study was to investigate the effects of 12 weeks of participation in a low-volume walking exercise programme (i.e. 90 min/week) combined with daily vitamin E supplementation on thiobarbituric acid reactive substances (TBARS) and oxidised low-density lipoprotein (LDL) concentrations in older adults.
Methods: The participants were recruited from the following four groups separately: 1) control (CG, n = 14), 2) vitamin E supplementation (SG, n = 10), 3) walking (WG, n = 7), or 4) walking + supplementation (WSG, n = 7). In the CG, participants were advised to maintain their normal lifestyle during the study. Participants in both the SG and WSG received 450 IU (300 mg) /day of a-tocopherol for 12 weeks. The exercise programme for the WG and WSG consisted of two 30-60 minute sessions weekly for 12 weeks (average walking time was 44.5 +/- 1.6 min/session). Blood samples were collected at baseline and at 12 weeks.
Results: Delta plasma oxidised LDL concentrations did not differ among four groups (One-factor ANOVA, P = 0.116). However, negative delta plasma TBARS, a marker of oxidative damage, concentrations were observed in the WG, WSG and SG relative to the CG at the end of the study period (One-factor ANOVA, P = 0.001; post hoc tests; CG compared with WG, WSG and SG, P = 0.005; P = 0.021; P = 0.024, respectively).
Conclusion: These findings suggest that a low-volume of physical activity and/or vitamin E supplementation may be an effective intervention strategy for reducing TBARS concentrations of older adults.
Trial registration: UMIN000008304

The purpose of this study was to investigate the effects of low-volume exercise training (100 min/week) on oxidative stress and neutrophils activation markers in older adults. Twenty-eight older adults (age range 65-78 years) were assigned into control (n = 14) or exercise (n = 14) groups. The exercise program consisted of walking 30-60 min/session, 2 days each week for 12 weeks. Blood samples were taken before starting the sessions (baseline) and when they ended. Fasting plasma and serum oxidative stress and inflammatory markers were measured using commercial kits. Cell surface expression of adhesion molecules on circulating leukocytes (CD66b and CD62L) was determined using flow cytometry. The concentrations of derivatives of reactive oxygen metabolites tended to be lower than the baseline values only in the exercise group (P = 0.05). The biological antioxidant potential, thioredoxin concentrations, and glutathione peroxidase activities significantly increased only in the exercise group (P < 0.05 for all). While CD66b expression tended to decrease only in the exercise group, CD62L expression significantly increased (P < 0.05). Our findings indicate that exercise training below the current recommended level of at least 150 min/week attenuates basal oxidative stress and neutrophil activation in older adults. Thus, our findings may encourage more people to incorporate a small amount of physical activity into their lives.

The aim of this study was to investigate the effects of one night of sleep deprivation on maximal fat oxidation during a graded exercise test. Ten healthy young males underwent two 2-day control and sleep deprivation trials. Participants were allowed normal sleep from 2300 to 0700 for the control trial, whereas they were required to stay awake for 34 h during the sleep deprivation trial. At 1700 on day 2, participants performed a graded exercise test to exhaustion on a treadmill; this allowed us to determine maximal oxygen uptake and maximal fat oxidation. Before and immediately after the graded exercise test, blood samples were collected in order to measure glucose, insulin, free fatty acid, and triglyceride concentrations. Plasma glucose concentrations were significantly higher in the sleep deprivation trial than in the control trial before the graded exercise test. Serum insulin and free fatty acid concentrations were not significantly different between the two trials. Serum triglyceride concentrations were significantly lower in the sleep deprivation trial than in the control trial. The maximal fat oxidation rate, oxygen uptake, and heart rate at maximal fat oxidation intensity

:The purpose of this study was to investigate the effects of low-volume exercise training (90 min/wk) and vitamin E supplementation on oxidative stress markers in postmenopausal women. The participants were non-randomly assigned the following four groups: control (C, n=8), vitamin E (S, n=8), exercise (Ex, n=6), or vitamin E and exercise (S+Ex, n=7). The S and S+Ex groups were instructed to take vitamin E (α-tocopherol, 300 mg/d) capsules for 12 wk. The exercise program of Ex and S+Ex groups consisted of walking for a 30-60 min/session 2 d per week for 12 wk. The serum derivatives of reactive oxygen metabolites concentrations were significantly decreased in the Ex, and S+Ex groups after 12 wk compared with the baseline values (three-factor ANOVA, an interaction between exercise and time, p<0.05). Conversely, serum biological antioxidant potential concentrations in the S and Ex groups were significantly higher at 12 wk than at the baseline, but not in the S+Ex group (three-factor ANOVA, an interaction between supplementation, exercise and time, p<0.05). Plasma thioredoxin concentrations in the S, Ex, and S+Ex groups were significantly higher at 12 wk than at the baseline values (three-factor ANOVA, interactions between exercise and time, and between supplementation, exercise and time, p<0.05). Our findings suggest that low-volume physical activity may improve resting oxidative stress status in postmenopausal women.

:Oxidative stress increases with advancing age and is a mediator of several diseases including cancer, cardiovascular disease, and diabetes. Moreover, postmenopausal women have a lower estrogen concentration, which is associated with elevated oxidative stress. However, there is no definitive evidence regarding the relationship between daily physical activity and oxidative stress status in older adults, including postmenopausal women. Twenty-nine adults (age, 70.1 ± 1.0 years, mean ± SE; 12 women and 17 men) were examined in this cross-sectional study. Prior to blood collection, the participants were asked to wear a uniaxial accelerometer for 4 consecutive weeks to determine their level of physical activity. After a 48-h period of physical activity avoidance and a 10-h overnight fast, venous blood samples were obtained from each participant. Fasting plasma derivatives of reactive oxygen metabolites (d-ROMs) and malondialdehyde (MDA) concentrations of oxidative stress markers were negatively correlated with the amount of physical activity in women (d-ROMs; r = -0.708, p = 0.002) (MDA; r = -0.549, p = 0. 028), but not in men. Fasting plasma biological antioxidant potential of antioxidant capacity marker was positively correlated with the amount of physical activity in women (BAP; r = 0.657, p = 0.006) (GSH; r = 0.549, p = 0.028), but not in men. Moreover, superoxide dismutase activity of antioxidant capacity marker was positively correlated with the amount of physical activity in men (r = 0.627, p = 0.039), but not in women. There were no associations between physical activity and other oxidative stress markers (reduced and oxidized glutathione, glutathione peroxidise, thioredoxin). These findings suggest that regular physical activity may have a protective effect against oxidative stress by increasing total antioxidant capacity, especially in postmenopausal women. Key PointsIt is important to consider daily physical activity status when evaluating antioxidant capacity.Sex differences affect the alteration of oxidative stress markers induced by daily physical activity.Regular physical activity may have a protective effect against oxidative stress by increasing total antioxidant capacity, especially in postmenopausal women.

:Over the last two decades, significant research attention has been given to the acute effect of a single bout of exercise on postprandial lipaemia. A large body of evidence supports the notion that an acute bout of aerobic exercise can reduce postprandial triacylglycerol (TAG) concentrations. However, this effect is short-lived emphasising the important role of regular physical activity for lowering TAG concentrations through an active lifestyle. In 1995, the concept of accumulating physical activity was introduced in expert recommendations with the advice that activity can be performed in several short bouts throughout the day with a minimum duration of 10 minutes per activity bout. Although the concept of accumulation has been widely publicised, there is still limited scientific evidence to support it but several studies have investigated the effects of accumulated activity on health-related outcomes to support the recommendations in physical activity guidelines. One area, which is the focus of this review, is the effect of accumulating exercise on postprandial lipaemia. We propose that accumulating exercise will provide additional physical activity options for lowering postprandial TAG concentrations relevant to individuals with limited time or exercise capacity to engage in more structured forms of exercise, or longer bouts of physical activity. The benefits of accumulated physical activity might translate to a reduced risk of cardiovascular disease in the long-term.

Over the last two decades, significant research attention has been given to the acute effect of a single bout of exercise on postprandial lipaemia. A large body of evidence supports the notion that an acute bout of aerobic exercise can reduce postprandial triacylglycerol (TAG) concentrations. However, this effect is short-lived emphasising the important role of regular physical activity for lowering TAG concentrations through an active lifestyle. In 1995, the concept of accumulating physical activity was introduced in expert recommendations with the advice that activity can be performed in several short bouts throughout the day with a minimum duration of 10 minutes per activity bout. Although the concept of accumulation has been widely publicised, there is still limited scientific evidence to support it but several studies have investigated the effects of accumulated activity on health-related outcomes to support the recommendations in physical activity guidelines. One area, which is the focus of this review, is the effect of accumulating exercise on postprandial lipaemia. We propose that accumulating exercise will provide additional physical activity options for lowering postprandial TAG concentrations relevant to individuals with limited time or exercise capacity to engage in more structured forms of exercise, or longer bouts of physical activity. The benefits of accumulated physical activity might translate to a reduced risk of cardiovascular disease in the long-term. Copyright © 2013 The Korean Society for Preventive Medicine.

Vigorous running suppresses plasma acylated ghrelin concentrations but the limited literature on cycling suggests that acylated ghrelin is unchanged, perhaps because body mass is supported during cycling. It is important from a research and applied perspective to determine whether acylated ghrelin and hunger responses are exercise-mode specific. This study sought to examine this. Eleven recreationally active males fasted overnight and completed three 4-h trials: control, running, and cycling, in a random order. Participants rested throughout the control trial and ran or cycled at 70% of mode-specific maximal oxygen uptake for the first hour during exercise trials, resting thereafter. Hunger was measured every 0.5 h using visual analogue scales. Eight venous blood samples were collected to determine acylated ghrelin concentrations and a standardised meal was consumed at 3 h. Compared with the control trial, acylated ghrelin concentrations were suppressed to a similar extent at 0.5 and 1 h during the running (p &lt; 0.005) and cycling (p &lt; 0.001) trials. Area under the curve values for ghrelin concentration over time were lower during exercise trials versus control (Control: 606 +/- 379; Running: 455 +/- 356; Cycling: 448 +/- 315 pg.mL(-1).4 h(-1); mean +/- SD, p &lt; 0.05). Hunger values did not differ significantly between trials but an interaction effect (p &lt; 0.05) indicated a tendency for hunger to be suppressed during exercise. Thus, at similar relative exercise intensities, plasma acylated ghrelin concentrations are suppressed to a similar extent during running and cycling.

Long periods of sedentary behaviour may adversely affect health irrespective of overall physical activity levels. This study compared the effects of sitting, standing and walking on postprandial lipaemia in healthy normolipidaemic Japanese men. 15 participants, aged 26.8 +/- 2.0 years (mean +/- SD), completed 3, 2-day trials in a random order: 1) sitting (control), 2) standing, and 3) walking. On day 1 of the sitting trial, participants rested. On day 1 of the standing trial, participants stood for six, 45-min periods. On day 1 of the walking trial, participants walked briskly for 30 min at approximately 60 % of maximum heart rate. On day 2 of each trial, participants rested and consumed test meals for breakfast and lunch. Venous blood samples were collected in the morning and afternoon on day 1, and in the fasted state (0 h) and at 2, 4 and 6 h postprandially on day 2. On day 2 area under the serum triacylglycerol concentration vs. time curve was 18 % lower on the walking trial than the sitting and standing trials (1-factor ANOVA, P = 0.015). Hence postprandial lipaemia was not reduced after standing but was reduced after low-volume walking compared with sitting in healthy normolipidaemic Japanese men.

The aim of this study was to investigate the effects of sleep deprivation on autonomic and endocrine functions during the day and on exercise tolerance in the evening. Ten healthy young males completed two, 2-day control and sleep deprivation trials. For the control trial, participants were allowed normal sleep from 23:00 to 07:00 h. For the sleep deprivation trial, participants did not sleep for 34 h. Autonomic activity was measured from 19:00 h on day 1 to 16:00 h on day 2 by frequency-domain measures of heart rate variability. Endocrine function was examined by measuring adrenocorticotropic hormone and cortisol from venous blood samples collected on day 2 at 09:00, 13:00, and 17:00 h and immediately after an exercise tolerance testing. Autonomic regulation, particularly parasympathetic regulation estimated from the high-frequency component of heart rate variability analysis, was significantly higher in the sleep deprivation trial than in the control trial in the morning and afternoon of day 2. Plasma adrenocorticotropic hormone concentrations were significantly higher at 09:00 and 13:00 h of day 2 under sleep deprivation. Heart rate during exercise was significantly lower following sleep deprivation. Therefore, the effects of sleep deprivation on autonomic regulation depend on the time of the day. © 2013 Copyright Taylor and Francis Group, LLC.

The purpose of this study was to investigate the effects of low-volume exercise training (90 min/wk) and vitamin E supplementation on oxidative stress markers in postmenopausal women. The participants were non-randomly assigned the following four groups: control (C, n=8), vitamin E (S, n=8), exercise (Ex, n=6), or vitamin E and exercise (S+Ex, n=7). The S and S+Ex groups were instructed to take vitamin E (α-tocopherol, 300 mg/d) capsules for 12 wk. The exercise program of Ex and S+Ex groups consisted of walking for a 30-60 min/session 2 d per week for 12 wk. The serum derivatives of reactive oxygen metabolites concentrations were significantly decreased in the Ex, and S+Ex groups after 12 wk compared with the baseline values (three-factor ANOVA, an interaction between exercise and time, p&lt
0.05). Conversely, serum biological antioxidant potential concentrations in the S and Ex groups were significantly higher at 12 wk than at the baseline, but not in the S+Ex group (three-factor ANOVA, an interaction between supplementation, exercise and time, p&lt
0.05). Plasma thioredoxin concentrations in the S, Ex, and S+Ex groups were significantly higher at 12 wk than at the baseline values (three-factor ANOVA, interactions between exercise and time, and between supplementation, exercise and time, p&lt
0.05). Our findings suggest that low-volume physical activity may improve resting oxidative stress status in postmenopausal women.

Foods high in monounsaturated fat, such as olive oil, and endurance exercise are both known to independently reduce postprandial TAG concentrations. We examined the combined effects of exercise and dietary fat composition on postprandial TAG concentrations in nine healthy pre-menopausal females (age 26.8 (SD 3.3) years, BMI 22.3 (SD 2.0) kg/m(2)). Each participant completed four, 2d trials in a randomised order: (1) butter-no exercise, (2) olive oil-no exercise, (3) butter-exercise, (4) olive oil-exercise. On day 1 of the exercise trials, participants walked or ran on a treadmill for 60min. On the no-exercise trials, participants rested on day 1. On day 2 of each trial, participants rested and consumed an olive oil meal (saturated fat 15% and unsaturated fat 85 %) or a butter meal (saturated fat 71% and unsaturated fat 29 %) for breakfast. Venous blood samples were obtained in the fasted state and for 6 h postprandially on day 2. A significant main effect on physical activity (exercise or control) was obtained for plasma TAG concentration (three-way ANOVA, P=0.043), and the total area under the concentration v. time curve for TAG was 26% lower on the olive oil-exercise trial (4.40 (SD 0.40) mmol x 6 h/l) than the butter-no exercise trial (5.91 (SD 1.01) mmol x 6 h/l) (one-way ANOVA, P=0.029). These findings suggest that the combination of exercise and a preference for monounsaturated dietary fat intake in the form of olive oil may be most beneficial for reducing postprandial TAG concentrations.

Cardiovascular disease is a major cause of death in many developed countries. Impaired clearance of postprandial triacylglycerol has been associated with an increase in cardiovascular disease risk. Physical activity can reduce many cardiovascular disease risk factors including postprandial triacylglycerol concentrations. Public health guidelines suggest that physical activity can be accumulated in several short bouts throughout the day, with a minimum duration of 10 minutes per activity bout. Until recently, limited evidence was available to support the effect of accumulating physical activity on postprandial lipaemia. Thus, the authors conducted a series of investigations to examine the influence of accumulated physical activity on postprandial lipaemia. The implications of the research findings are discussed in keeping with practical guidance for those wishing to engage in exercise that will lower postprandial triacylglycerol concentrations.

Objectives: The purpose of the study was to examine the relationships among the psychological, social, and environmental factors influencing the utilization of senior centers among older adults in Korea. Methods: A questionnaire survey was administered to two types of older adults who lived in Seoul, Korea: 262 older adults who used senior centers (3 places) and 156 older adults who did not use senior centers. Results: Our results showed clearly that the utilization of the senior centers in Korea is affected by higher self-efficacy (odds ratio [OR], 6.08
95% confidence interval [CI], 3.31 to 12.32), higher perceived benefits (OR, 1.71
95% CI, 1.16 to 4.36), lower perceived barriers (OR, 6.43
95% CI, 3.07 to 11.45), higher family support (OR, 4.21
95% CI, 2.02 to 8.77), and higher support from friends (OR, 4.08
95% CI, 2.38 to 7.81). The results also showed that participants whose total travel time was 15 to 29 minutes (OR, 2.84
95% CI, 1.21 to 3.64) or less than 14 minutes (OR, 4.68
95% CI, 3.41 to 8.41) were more likely to use a senior center than those who had to travel more than 30 minutes. Conclusions: This study showed that the utilization of senior centers in Korea is affected by psychological, social, and environmental factors, specifically by self-efficacy, perceived benefits, perceived barriers, social support, convenience of transportation, and total travel time to the senior centers. The effects of longer-term utilization of the senior centers by non-users on health-related outcomes in a large population warrant attention. Copyright © 2012 The Korean Society for Preventive Medicine.

Background: Endothelial dysfunction is associated with childhood obesity and is closely linked to the amount and function of endothelial progenitor cells. However, it remains unclear whether endothelial progenitor cells increase with after-school exercise in overweight and obese children. The purpose of this study was to investigate the effects of an after-school exercise programme on endothelial cell function in overweight and obese children.
Methods: A total of 29 overweight/obese children (12.2 +/- 0.1 years) were randomly divided into control (i.e. no after-school exercise, n = 14) and after-school exercise (n = 15) groups. The 12-week after-school exercise intervention consisted of 3 days of combined aerobic and resistance exercise per week. Each 80-minute exercise programme included 10 minutes of warm-up and 10 minutes of cool-down after school. CD34(+) (a cell surface marker on hematopoietic stem cells), CD133(+) (a cell surface marker on hematopoietic progenitor cells) and CD34(+)/CD133(+) (considered as endothelial progenitor cells) were measured at baseline and after 12 weeks using flow cytometry.
Results: Increased percentages of CD34(+), CD133(+) and CD34(+)/CD133(+) cells were observed in the after-school exercise group (p = 0.018; p = 0.001; p = 0.002, respectively) compared with the control group. Carotid intima-media thickness decreased after 12 weeks in the after-school exercise group (p = 0.020) compared with the control group.
Conclusions: This study provides preliminary evidence that a combined after-school exercise programme may represent an effective intervention strategy for improving vascular repair and endothelial cell function, leading to improved cardiovascular health in overweight and obese children.

Introduction: The hallmark features of obesity include insulin resistance and an impaired ability to oxidize lipids. As compared to exercise training, it remains relatively unclear if diet-induced weight loss can also induce fat metabolism. This study was undertaken to examine the effects of diet-induced weight loss on fat metabolism during a single session of exercise in middle-aged obese men. Methods: Fifteen obese men who were otherwise healthy (average age of 53.5 +/- 6.9 yr and average body mass index of 27.8 +/- 1.6 kg/m(2)) participated in a 12-wk weight loss program primarily consisting of dietary modification. Maximal fat oxidation (MFO) rates, MFO per lean body mass (MFOLBM) and insulin resistance (HOMA-IR) were measured before and after the program. Participants performed a 24-min graded exercise test on a cycle ergometer, with 15-W increments every 4 min. Expired gas analysis was performed by indirect calorimetry, and nonprotein respiratory quotient equations were used to calculate fat oxidation rates. Results: The weight (-8.3 +/- 3.8 kg), fat mass (-4.5 +/- 1.9 kg), and lean body mass (-3.8 +/- 2.4 kg) (P &lt; 0.001 for all measurements) of the participants were decreased at the end of the 12-wk program. The MFO tended to increase by 19% (P = 0.08) and MFOLBM significantly increased by 28.8% (P = 0.02). Although insulin resistance also significantly decreased by 49% (P &lt; 0.001), changes in fat oxidation variables did not correlate with changes in insulin resistance. Conclusion: Diet-induced weight loss improves fat metabolism with the improvement in insulin resistance. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Background: When previously sedentary males and females follow the same exercise training programs with ad libitum feeding, males reduced body mass, but females do not, which suggests that females may increase appetite in response to exercise training compared with males. Rope skipping is traditional exercise modality that everyone had experienced during elementary school years in Japan. The purpose of this study was to determine whether there is a sex difference on appetite after acute rope skipping exercise.
Methods and results: Thirteen healthy young males (22.5 +/- 0.8 years, 172.2 +/- 1.7 cm, 68.8 +/- 2.3 kg, 18.4 +/- 0.9%) and 13 females (22.9 +/- 0.8 years, 160.6 +/- 1.5 cm, 52.9 +/- 1.6 kg, 25.0 +/- 1.0%) participated in this study. Subjects consumed their lunch by 13:00, and performed a total of 20 min rope skipping exercise (2 sets x 10 min with 5 min interval) from 16:00. In females, appetite significantly increased from immediately after the exercise to 30 min after the exercise (from 13 mm to 30 mm), but remained unchanged in males. Although heart rate, ratings of perceived exertion, and lactate concentrations increased from baseline to immediately after exercise, there were no differences in the increase between males and females. Blood glucose concentrations at baseline and 30 min after exercise were higher in females than in males.
Conclusion: These results indicated that rope skipping exercise induces an increase in appetite in females, but not in males. This increased appetite in females after the rope skipping exercise was induced without change in blood glucose concentrations. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Background: When previously sedentary males and females follow the same exercise training programs with ad libitum feeding, males reduced body mass, but females do not, which suggests that females may increase appetite in response to exercise training compared with males. Rope skipping is traditional exercise modality that everyone had experienced during elementary school years in Japan. The purpose of this study was to determine whether there is a sex difference on appetite after acute rope skipping exercise.
Methods and results: Thirteen healthy young males (22.5 +/- 0.8 years, 172.2 +/- 1.7 cm, 68.8 +/- 2.3 kg, 18.4 +/- 0.9%) and 13 females (22.9 +/- 0.8 years, 160.6 +/- 1.5 cm, 52.9 +/- 1.6 kg, 25.0 +/- 1.0%) participated in this study. Subjects consumed their lunch by 13:00, and performed a total of 20 min rope skipping exercise (2 sets x 10 min with 5 min interval) from 16:00. In females, appetite significantly increased from immediately after the exercise to 30 min after the exercise (from 13 mm to 30 mm), but remained unchanged in males. Although heart rate, ratings of perceived exertion, and lactate concentrations increased from baseline to immediately after exercise, there were no differences in the increase between males and females. Blood glucose concentrations at baseline and 30 min after exercise were higher in females than in males.
Conclusion: These results indicated that rope skipping exercise induces an increase in appetite in females, but not in males. This increased appetite in females after the rope skipping exercise was induced without change in blood glucose concentrations. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Introduction: The hallmark features of obesity include insulin resistance and an impaired ability to oxidize lipids. As compared to exercise training, it remains relatively unclear if diet-induced weight loss can also induce fat metabolism. This study was undertaken to examine the effects of diet-induced weight loss on fat metabolism during a single session of exercise in middle-aged obese men. Methods: Fifteen obese men who were otherwise healthy (average age of 53.5 +/- 6.9 yr and average body mass index of 27.8 +/- 1.6 kg/m(2)) participated in a 12-wk weight loss program primarily consisting of dietary modification. Maximal fat oxidation (MFO) rates, MFO per lean body mass (MFOLBM) and insulin resistance (HOMA-IR) were measured before and after the program. Participants performed a 24-min graded exercise test on a cycle ergometer, with 15-W increments every 4 min. Expired gas analysis was performed by indirect calorimetry, and nonprotein respiratory quotient equations were used to calculate fat oxidation rates. Results: The weight (-8.3 +/- 3.8 kg), fat mass (-4.5 +/- 1.9 kg), and lean body mass (-3.8 +/- 2.4 kg) (P &lt; 0.001 for all measurements) of the participants were decreased at the end of the 12-wk program. The MFO tended to increase by 19% (P = 0.08) and MFOLBM significantly increased by 28.8% (P = 0.02). Although insulin resistance also significantly decreased by 49% (P &lt; 0.001), changes in fat oxidation variables did not correlate with changes in insulin resistance. Conclusion: Diet-induced weight loss improves fat metabolism with the improvement in insulin resistance. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

BACKGROUND:Endothelial dysfunction is associated with childhood obesity and is closely linked to the amount and function of endothelial progenitor cells. However, it remains unclear whether endothelial progenitor cells increase with after-school exercise in overweight and obese children. The purpose of this study was to investigate the effects of an after-school exercise programme on endothelial cell function in overweight and obese children.;METHODS:A total of 29 overweight/obese children (12.2 ± 0.1 years) were randomly divided into control (i.e. no after-school exercise, n = 14) and after-school exercise (n = 15) groups. The 12-week after-school exercise intervention consisted of 3 days of combined aerobic and resistance exercise per week. Each 80-minute exercise programme included 10 minutes of warm-up and 10 minutes of cool-down after school. CD34(+) (a cell surface marker on hematopoietic stem cells), CD133(+) (a cell surface marker on hematopoietic progenitor cells) and CD34(+)/CD133(+) (considered as endothelial progenitor cells) were measured at baseline and after 12 weeks using flow cytometry.;RESULTS:Increased percentages of CD34(+), CD133(+) and CD34(+)/CD133(+) cells

OBJECTIVES:The purpose of the study was to examine the relationships among the psychological, social, and environmental factors influencing the utilization of senior centers among older adults in Korea.;METHODS:A questionnaire survey was administered to two types of older adults who lived in Seoul, Korea: 262 older adults who used senior centers (3 places) and 156 older adults who did not use senior centers.;RESULTS:Our results showed clearly that the utilization of the senior centers in Korea is affected by higher self-efficacy (odds ratio [OR], 6.08; 95% confidence interval [CI], 3.31 to 12.32), higher perceived benefits (OR, 1.71; 95% CI, 1.16 to 4.36), lower perceived barriers (OR, 6.43; 95% CI, 3.07 to 11.45), higher family support (OR, 4.21; 95% CI, 2.02 to 8.77), and higher support from friends (OR, 4.08; 95% CI, 2.38 to 7.81). The results also showed that participants whose total travel time was 15 to 29 minutes (OR, 2.84; 95% CI, 1.21 to 3.64) or less than 14 minutes (OR, 4.68; 95% CI, 3.41 to 8.41) were more likely to use a senior center than those who had to travel more than 30 minutes.;CONCLUSIONS:This study showed that the utilization of senior centers in Korea is affected by psychological, social, and environmental factors, specifically by self-efficacy, perceived benefits, perceived barriers, social support, convenience of transportation, and total travel time to the senior centers. The effects of longer-term utilization of the senior centers by non-users on health-related outcomes in a large population warrant attention.

Objective: The purpose of the present study was to examine the relationship between the use of senior center and health-related quality of life in Korean older adults. Methods: A questionnaire survey was conducted to two types of older adults who lived in Busan, Korea: 154 older adults who used a senior center and 137 older adults who did not use a senior center. The Korean version of short-form 36-item health survey was administered to assess the health-related quality of life. Demographic variables were obtained from a questionnaire. These were gender, age, family status, marital status, education, monthly income, present illness, body mass index and physical activity. Results: The 8-domain scales of physical function and role-physical were significantly higher in the users of the senior center compared with the non-users (F=4.87, p=0.027 and F=7.02, p=0.009, respectively). The 8-domain scales of vitality was also significantly higher in the users of the senior center compared with the non-users (F=7.48, p=0.007). Conclusions: The present study showed that the users of the senior center have higher physical function, role-physical and vitality compared with the non-users. These findings suggest that although the results are unable to specify causal relationships using the senior center may lead to some improvement in health-related quality of life.

Physical activity-induced lowering of postprandial lipaemia is short-lived. However, little is known regarding the role of physical activity status on postprandial lipaemia. The purpose of the present study was to compare postprandial triacylglycerol concentrations in active and inactive older adults. A total of 26 older adults (aged 69.8±0.9 years, mean±SEM
10 male and 16 female) were analysed in a cross-sectional design. Based on accelerometer data, participants were divided into either the active group (150min/week of moderate-intensity physical activity, n=15) or the inactive group (&lt
150min/week of moderate-intensity physical activity, n=11). After a 48-h period of physical activity avoidance and a 10-h overnight fast, participants consumed a test meal of moderate fat content (35%). Capillary blood samples were collected in the fasted state and at 2, 4, and 6h postprandially. After adjusting for fasting triacylglycerol concentrations, body mass, body mass index and waist circumference, postprandial capillary triacylglycerol concentrations were significantly lower in the active than inactive group (P=0.046). These findings demonstrate that regular physical activity lowers postprandial lipaemia independent of the acute effects of physical activity in older adults. © Georg Thieme Verlag KG Stuttgart · New York.

In this study, we compared the effects of accumulated and continuous running on resting arterial blood pressure. Ten normotensive/pre-hypertensive men, aged 25.0 ± 4.2 years (mean ± s), participated in three 2-day trials at least one week apart in a randomized, repeated-measures design. On Day 1, participants rested (control) or ran at 70% of maximum oxygen uptake in either ten 3-min bouts (30 min rest between bouts) or one continuous 30-min bout. On Day 2, participants rested throughout the day. Blood pressure was measured at hourly intervals throughout Days 1 and 2. Mean resting systolic blood pressure on Day 2 was 6% lower during the accumulated and continuous running trials compared with the control trial (110 ± 6 vs. 110 ± 8 vs. 117 ± 6 mmHg respectively
P &lt
0.05), but there were no differences in resting diastolic blood pressure among the three trials (70 ± 7 vs. 69 ± 6 vs. 70 ± 5 mmHg respectively). These findings demonstrate that accumulating 30 min of running throughout the day in short bouts is as effective as 30 min of continuous running for reducing resting systolic blood pressure on the next day in young normotensive/pre-hyptertensive men. © 2011 Taylor &amp
Francis Group, LLC.

OBJECTIVE:The purpose of the present study was to examine the relationship between the use of senior center and health-related quality of life in Korean older adults.;METHODS:A questionnaire survey was conducted to two types of older adults who lived in Busan, Korea: 154 older adults who used a senior center and 137 older adults who did not use a senior center. The Korean version of short-form 36-item health survey was administered to assess the health-related quality of life. Demographic variables were obtained from a questionnaire. These were gender, age, family status, marital status, education, monthly income, present illness, body mass index and physical activity.;RESULTS:The 8-domain scales of physical function and role-physical were significantly higher in the users of the senior center compared with the non-users (F=4.87, p=0.027 and F=7.02, p=0.009, respectively). The 8-domain scales of vitality was also significantly higher in the users of the senior center compared with the non-users (F=7.48, p=0.007).;CONCLUSIONS:The present study showed that the users of the senior center have higher physical function, role-physical and vitality compared with the non-users. These findings suggest that although the results are unable to specify causal relationships using the senior center may lead to some improvement in health-related quality of life.

AIM:Oxidised low-density lipoprotein (LDL) is considered a risk marker for cardiovascular disease. However, it remains unclear whether oxidised LDL concentrations differ with the physical activity status in older adults. The purpose of this study was to examine the relationship between the amount of physical activity and oxidised LDL in older adults.;METHODS:Twenty-seven older adults (aged 69.9 ± 4.3 years, mean ± SD.; 16 female and 11 male) were analysed in the cross-sectional design. Prior to blood collection, participants were asked to wear an uniaxial accelerometer for 4 consecutive weeks to determine the physical activity status. After a 48-h period of physical activity avoidance and a 10-h overnight fast, fasting venous blood samples were obtained from each participant.;RESULTS:Fasting plasma oxidised LDL concentrations and plasma monocyte chemoattractant pro-tein-1 concentrations were negatively correlated with the amount of physical activity (r=-0.409, p=0.034; r=-0.385, p=0.047, respectively).;CONCLUSIONS:This study demonstrates that regular physical activity may play a protective role in the oxidation of LDL in older adults.

Aim: Oxidised low-density lipoprotein (LDL) is considered a risk marker for cardiovascular disease. However, it remains unclear whether oxidised LDL concentrations differ with the physical activity status in older adults. The purpose of this study was to examine the relationship between the amount of physical activity and oxidised LDL in older adults.
Methods: Twenty-seven older adults (aged 69.9 +/- 4.3 years, mean +/- SD.; 16 female and 11 male) were analysed in the cross-sectional design. Prior to blood collection, participants were asked to wear an uniaxial accelerometer for 4 consecutive weeks to determine the physical activity status. After a 48-h period of physical activity avoidance and a 10-h overnight fast, fasting venous blood samples were obtained from each participant.
Results: Fasting plasma oxidised LDL concentrations and plasma monocyte chemoattractant protein-1 concentrations were negatively correlated with the amount of physical activity (r = -0.409, p = 0.034; r = -0.385, p = 0.047, respectively).
Conclusions: This study demonstrates that regular physical activity may play a protective role in the oxidation of LDL in older adults.

In this study, we compared the effects of accumulated and continuous running on resting arterial blood pressure. Ten normotensive/pre-hypertensive men, aged 25.0 +/- 4.2 years (mean +/- s), participated in three 2-day trials at least one week apart in a randomized, repeated-measures design. On Day 1, participants rested (control) or ran at 70% of maximum oxygen uptake in either ten 3-min bouts (30 min rest between bouts) or one continuous 30-min bout. On Day 2, participants rested throughout the day. Blood pressure was measured at hourly intervals throughout Days 1 and 2. Mean resting systolic blood pressure on Day 2 was 6% lower during the accumulated and continuous running trials compared with the control trial (110 +/- 6 vs. 110 +/- 8 vs. 117 +/- 6 mmHg respectively; P &lt; 0.05), but there were no differences in resting diastolic blood pressure among the three trials (70 +/- 7 vs. 69 +/- 6 vs. 70 +/- 5 mmHg respectively). These findings demonstrate that accumulating 30 min of running throughout the day in short bouts is as effective as 30 min of continuous running for reducing resting systolic blood pressure on the next day in young normotensive/pre-hyptertensive men.

The effects of prolonged treadmill running on appetite, energy intake and acylated ghrelin (an appetite stimulating hormone) were examined in 9 healthy males over the course of 24. h. Participants completed 2 experimental trials (exercise and control) in a randomised-crossover fashion. In the exercise trial participants ran for 90. min at 68.8 ± 0.8% of maximum oxygen uptake followed by 8.5. h of rest. Participants returned to the laboratory on the following morning to provide a fasting blood sample and ratings of appetite (24. h measurement). No exercise was performed on the control trial. Appetite was measured within the laboratory using visual analogue scales and energy intake was assessed from ad libitum buffet meals. Acylated ghrelin was determined from plasma using an ELISA assay. Exercise transiently suppressed appetite and acylated ghrelin but each remained no different from control values in the hours afterwards. Furthermore, despite participants expending 5324. kJ during exercise there was no compensatory increase in energy intake (24. h energy intake
control 17,191. kJ, exercise 17,606. kJ). These findings suggest that large energy deficits induced by exercise do not lead to acute compensatory responses in appetite, energy intake or acylated ghrelin. © 2010 Elsevier Ltd.

Aim: Enhancement of lipoprotein lipase (LPL) activity through drug administration has been shown to increase pre-heparin serum LPL concentrations; however, pre-heparin serum LPL responses to exercise training have not been determined. The present study was undertaken to investigate the effects of 12 weeks of supervised aerobic exercise training on pre-heparin serum LPL concentrations in overweight/obese men.
Methods: Fifteen overweight/obese middle-aged men were assigned to one of two 12-week supervised exercise interventions: a walking group (eight participants gradually increasing brisk walking to 60 min/day 3 days a week) or a jogging group (seven participants gradually increasing jogging to 60 min/day 3 days a week). All participants maintained ad libitum diets. Blood samples were collected at baseline and immediately after 12 weeks. The primary outcome was pre-heparin serum LPL.
Results: Pre-heparin serum LPL concentrations were increased in the jogging group after 12 weeks compared with the baseline values (mean +/- SEM: 37.6 +/- 4.7 vs. 51.0 +/- 6.6 ng/mL, respectively, p = 0.033). In the walking group, pre-heparin serum LPL concentrations remained unchanged after 12 weeks.
Conclusions: This study demonstrates that 12 weeks of jogging training increases pre-heparin serum LPL concentrations in overweight/obese middle-aged men.

In this study, we wished to determine whether 30min of moderate-intensity exercise, corresponding to minimal recommended guidelines, attenuates post-prandial capillary triacylglycerol concentrations in obese men. Ten middle-aged, centrally obese men (age 46 +/- 2 years, body mass index 31.6 +/- 1.0kg center dot m-2, waist circumference 104.6 +/- 2.2cm) completed two 2-day trials (exercise and control) at least one week apart in a randomized, repeated-measures design. On day 1, participants either cycled for 30min at approximately 60% of maximal heart rate in the afternoon or rested (no exercise). On day 2 of both trials, after a 10-h overnight fast, participants consumed a test meal of moderate fat content (35%) for breakfast. Capillary blood samples were collected in the fasted state (0h) and at 2, 4, and 6h post-prandially on day 2. Total area under the capillary triacylglycerol concentration versus time curve was significantly lower on the exercise than control trial (P=0.023). One 30-min session of moderate-intensity cycling is effective in lowering post-prandial capillary triacylglycerol concentration in obese middle-aged men. These findings may have important implications for exercise recommendations as a means to reduce the risk of cardiovascular disease if such exercise is performed for an extended period.

The current study investigated the acute effects of accumulating short bouts of running on circulating concentrations of postprandial triacylglycerol (TAG) and C-reactive protein (CRP). Ten men, age 21-32 yr, completed two 1-d trials. On 1 occasion participants ran at 70% of maximum oxygen uptake in six 5-min bouts (i.e., 8:30, 10, and 11:30 a.m. and 1, 2:30, and 4 p.m.) with 85 min rest between runs. On another occasion participants rested throughout the day. In both trials, participants consumed test meals at 9 a.m. and 12 p.m. In each trial, venous blood samples were collected at 8:30, 10, and 11:30 a.m. and 1, 2:30, 4, and 5:30 p.m. for plasma TAG measurement and at 8:30 a.m. and 5:30 p.m. for serum CRP measurement. Total area under the curve for plasma TAG concentration versus time was 10% lower on the exercise trial than the control trial (M +/- SEM: 13.5 +/- 1.8 vs. 15.0 +/- 1.9 mmol . 9 hr(-1) . L(-1); p = .004). Serum CRP concentrations did not differ between trials or over time. This study demonstrates that accumulating short bouts of running reduces postprandial plasma TAG concentrations (a marker for cardiovascular disease risk) but does not alter serum CRP concentrations.

After a single bout of prolonged strenuous exercise, inflammatory and muscle damage markers increase. The present study investigated whether vitamin E supplementation can attenuate inflammatory (C-reactive protein (CRP) and interleukin-6 (IL〜6)) and muscle damage (creatine kinase (CK) and lactate dehydrogenese (LDH)) markers after prolonged repeated bouts of cycling in healthy young men. Eight young males (aged 21-30 y) were received both vitamin E supplement (300 mg/day) and placebo (control) for 14 days separated by at least an interval of 1 month in a randomised, counterbalanced design. On day 12 of both trials, subjects cycled at 80% of maximal heart rate in two, 90-min bouts (150min rest between each). Blood samples were collected on days 1 (baseline), 12 (pre- and post-exercise 1 and pre- and post-exercise 2), 13, 14, and 15. After 14 days of supplementation, serum α-tocopherol concentrations increased in the vitamin E trial (P<0.0005) but not the placebo trial. Serum CRP concentrations did not differ between trials and did not significantly change over the observation period in both trials. Serum IL-6, CK, and LDH concentrations increased (P&le;0.024) in response to repeated bouts of exercise in both trials but did not differ between trials. The study demonstrates that short-term vitamin E supplementation appears to have no effect on attenuating markers of inflammatory and muscle damage in response to repeated bouts of prolonged exercise in healthy young men.

Background: Public health guidelines on physical activity recommend that adults accumulate 30 minutes of moderate intensity activity on most, preferably all, days of week (Department of Health UK, 2004; Pate et al., 1995). The guidelines also included the caveat that the minimum duration of any one bout should be 10 minutes. However, if total energy expenditure is the most important factor for health benefits, as is suspected (Pate et al., 1995), then the duration of exercise should not matter provided that sufficient energy is expended. The acute effect of a total of 30 minutes of accumulated exercise in bouts shorter than 10 minutes per session throughout the day on postprandial triacylglycerol concentrations has not been determined. Here we report the findings from two studies which compare the effects of accumulating ten, three-minute bouts of exercise versus one, 30-minute bout of exercise on postprandial triacylglycerol concentrations. Methods: Ten male subjects, aged 23±1 years (mean±SE) (running study) and 15 male subjects, aged 25±1 years (walking study) completed three, 2-day trials at least one week apart in a randomised, repeated measures design. On day 1, subjects rested (no exercise) or ran at 70% of maximum oxygen uptake (running study)/walked briskly at a self-selected pace (walking study) in either ten, three-minute bouts (i.e. 09:30 AM to 15:30 PM) with 30 minutes rest between each, or one continuous 30-minute bout (i.e. 15:00 to 15:30 PM). On day 2, subjects rested and consumed test meals (0.69 g fat, 0.95 g carbohydrate, 0.31 g protein, and 46 kJ/kg body mass) for breakfast and lunch. Venous blood samples were collected in the fasted state and for 7 h postprandially on day 2. Results: In both the running and the walking studies postprandial plasma triacylglycerol concentrations were significantly (two-way ANOVA, P<0.05) lower throughout day 2 on the accumulated and continuous exercise trials compared with the control trials: time-averaged postprandial concentrations 1.86 ± 0.32 versus 1.79 ± 0.33 versus 2.37 ± 0.45 mmol/L respectively for the running study and 1.33 ± 0.09 versus 1.36 ± 0.11 versus 1.62 ± 0.15 mmol/L respectively for the walking study. There were no significant differences between the accumulated and continuous exercise trials. Conclusion: These data demonstrate that: 1) accumulated physical activity is at least as effective as continuous physical activity in reducing postprandial plasma triacylglycerol concentrations in young men and 2) both walking and running are effective in reducing postprandial plasma triacylglycerol concentrations in young men.

Aerobic exercise has been shown to lower postprandial TAG concentrations after a meal(s) of high-fat content. This study examined the effects of moderate-intensity cycling on postprandial TAG concentrations and pre-heparin lipoprotein lipase concentrations after subjects consumed a meal of moderate-fat content (45 % of total energy). Twelve male subjects, aged 24 (sem 1) years, completed two 2 d trials (exercise and control) at least 1 week apart in a randomised, repeated measures design. On day 1, subjects either cycled for 30 min at 65 % of maximum heart rate in the afternoon or rested (no exercise). On day 2 of both trials, after an overnight stay with an 11 h fast, subjects consumed a test meal of moderate-fat content (0.61 g fat, 1.34 g carbohydrate, 0.37 g protein and 51 kJ energy/kg body mass) for breakfast. Blood samples were collected at baseline (before the exercise or at an equivalent time-point during the control trial on day 1), in the fasted state (0 h) and at 2, 4 and 6 h postprandially on day 2. The total and incremental areas under the serum TAG concentration v. time curve were 30 % (P = 0.039) and 33 % (P = 0.012) lower on the exercise trial compared with the control trial, respectively. Serum pre-heparin lipoprotein lipase concentrations did not differ between the exercise and control trials. These findings demonstrate that 30 min of moderate-intensity cycling performed the day before a meal of moderate-fat content is effective at lowering postprandial serum TAG concentrations but does not affect serum pre-heparin lipoprotein lipase concentrations in young men. © The Authors 2007.

BACKGROUND:Physical activity recommendations promote the accumulation of aerobic activity in bouts of &gt;or=10 min. It is important to determine whether shorter bouts of activity can influence health.;OBJECTIVE:We compared the effects of accumulating ten 3-min bouts of brisk walking with those of one 30-min bout of brisk walking on postprandial plasma triacylglycerol concentrations and resting blood pressure.;DESIGN:Fifteen healthy young men completed three 2-d trials &gt;or=1 wk apart in a randomized, repeated-measures design. On day 1, subjects rested (no exercise) or walked briskly in either ten 3-min bouts (30 min rest between each) or one 30-min bout (gross energy expenditure: 1.10 MJ/30 min). On day 2, subjects rested and consumed high-fat test meals for breakfast and lunch.;RESULTS:On day 2 area under the plasma triacylglycerol concentration over time curve was 16% lower on the accumulated and continuous brisk walking trials than on the control trial (x +/- SEM: 9.98 +/- 0.67 compared with 9.99 +/- 0.76 compared with 11.90 +/- 1.02 mmol x 7h/L, respectively; P = 0.005, one-factor ANOVA). Resting systolic blood pressure was 6-7% lower throughout day 2 on the accumulated and contin

OBJECTIVE:There is limited information regarding the effects of short (<10 min) bouts of activity on postprandial lipaemia and no studies are available regarding the effects of short bouts of activity on postprandial lipaemia in obese men. The objective of this study was to compare the effects of accumulating ten, 3-min bouts of exercise versus one 30 min bout of exercise on postprandial serum triacylglycerol (TAG) concentrations in obese men.;DESIGN:Each subject completed three 2-day trials at least 1 week apart in a randomized, repeated-measures design. On day 1, subjects rested (no exercise) or cycled at 60% of maximum heart rate in either ten, 3-min bouts (30 min rest between each), or one continuous 30-min bout. On day 2 of each trial, after an overnight fast, the subjects consumed a standardized test meal for breakfast. Venous blood samples were obtained in the fasted state (0 h), and 2, 4 and 6 h postprandially on day 2.;SUBJECTS:Eight sedentary men (age: 27+/-2 years) with body mass index between 25 and 37 kg/m(2).;MEASUREMENTS:Postprandial TAG, non-esterified fatty acids, 3-hydroxybutyrate, insulin and glucose were determined.;RESULTS:Total area under the postprandial serum TAG concentrations versus time curve was 18% (P=0.042) and 15% (P=0.032) lower throughout day 2 of both the accumulated exercise trial and the continuous exercise trial, respectively, compared with the control trial with little difference between exercise trials.;CONCLUSION:At 30 min of moderate cycling (0.87 MJ per 30 min) accumulated in short bouts is equally effective in reducing postprandial serum TAG concentrations as one continuous 30 min bout of cycling in obese men.

The present study examined how multiple bouts of resistance exercise, performed over 1 d, influence 2 risk factors-postprandial triacylglycerol (TAG) and serum C-reactive-protein (CRP) concentrations-associated with coronary heart disease. Twenty-four men age 23.5 (SD 3.4) y completed two 2-d trials, exercise and control, at least 1 wk apart in a counterbalanced randomized design. On day 1 of the exercise trials participants completed 20 sets of 15 repetitions of 5 different resistance exercises divided into five 45-min bouts of exercise-100 sets and 1500 repetitions in total for all exercises. Exercises were performed at 30-40% of 1-repetition maximum. Blood samples were taken before and after exercise. On day 1 of the control trial participants were inactive, with blood samples taken at time points corresponding to the exercise trial. On day 2 of both trials participants consumed a test meal (0.89 g fat, 1.23 g carbohydrate, 0.4 g protein, 60 kJ per kg body mass). Blood samples were obtained fasted and for 6 h postprandially. Total area under the postprandial TAG concentration versus time curve was 12% lower in the exercise than in the control trial (8.76 [3.54] vs. 9.94 [4.31] mmol.L-1.6 h, respectively; P = 0.037). Serum CRP concentrations did not change over the 2 d in the control trial but increased in the exercise trial: trial x time interaction (P = 0.028). Multiple bouts of resistance exercise reduce postprandial TAG concentrations but increase serum CRP concentrations. The extent to which these findings are clinically relevant requires further study.

:Ghrelin is a hormone that stimulates hunger. Intense exercise has been shown to temporarily suppress hunger after exercise. In the present study, we investigated whether post-exercise hunger suppression is mediated by reduced plasma total ghrelin concentrations. Nine men and nine women participated in the study. Their mean physical characteristics were as follows: age 24.8 (s(x) = 0.9) years, body mass index 22.9 (s(x) = 0.6) kg x m(-2), maximal oxygen uptake (VO(2max)) 57.7 (s(x) = 2.2) ml x kg(-1) x min(-1). The participants completed two 3-h trials (exercise and control) on separate days in a randomized balanced design after overnight fasts. The exercise trial involved a 1-h treadmill run at 73.5% of VO(2max) followed by 2 h of rest. The control trial consisted of 3 h of rest. Blood samples were collected at 0, 0.5, 1, 1.5, 2, and 3 h. Total ghrelin concentrations were determined from plasma. Hunger was assessed following blood sampling using a 15-point scale. The data were analysed using repeated-measures analysis of variance. Hunger scores were lower in the exercise trial than in the control trial (trial, P = 0.009; time, P &lt; 0.001; trial x time, P &lt; 0.001). Plasma total ghre

:Ghrelin is an orexigenic hormone secreted from endocrine cells in the stomach and other tissues. Acylation of ghrelin is essential for appetite regulation. Vigorous exercise induces appetite suppression, but this does not appear to be related to suppressed concentrations of total ghrelin. This study examined the effect of exercise and feeding on plasma acylated ghrelin and appetite. Nine male subjects aged 19-25 yr participated in two, 9-h trials (exercise and control) in a random crossover design. Trials began at 0800 in the morning after an overnight fast. In the exercise trial, subjects ran for 60 min at 72% of maximum oxygen uptake between 0800 and 0900. After this, they rested for 8 h and consumed a test meal at 1100. In the control trial, subjects rested for 9 h and consumed a test meal at 1100. Area under the curve values for plasma acylated ghrelin concentration (assessed from venous blood samples) were lower over the first 3 h and the full 9 h of the exercise trial compared with the control trial: 317+/-135 vs. 510+/-186 pg.ml(-1).3 h and 917+/-342 vs. 1,401+/-521 pg.ml(-1).9 h (means+/-SE) respectively (P&lt;0.05). Area under the curve values for hunger (assessed using a vi

PURPOSE:There is conflicting evidence whether a single bout of resistance exercise performed the day before a test meal can lower postprandial triacylglycerol (TAG) concentrations. The present study examined the effect of a single session of resistance exercise, performed the same day as a test meal, on postprandial TAG concentrations in resistance-trained males.;METHODS:Ten healthy males aged 25 (SD 2.6) yr performed two trials at least 1 wk apart in a counterbalanced, randomized design. In each trial, participants consumed a test meal (0.89 g of fat, 1.23 g of carbohydrate, 0.4 g of protein, 60 kJ.kg body mass). Before one meal, participants performed a 90-min bout of resistance exercise. Before the other meal, participants were inactive (control trial). Resistance exercise was performed using free weights and included three sets of 12 repetitions of each of 10 exercises. Sets were performed at 80% of 12-repetition maximum with a 3-min work and rest interval. Venous blood samples were obtained in the fasted state and for 5 h postprandially.;RESULTS:Total area under the plasma TAG concentration versus time curve was higher (Student&#039;s t-test P = 0.008) on the exercise than control

BACKGROUND:Guidelines state that accumulated physical activity is beneficial for health, but a minimum duration of 10 min per activity bout is recommended. Limited information regarding the effects of short (< 10 min) bouts of activity on health is available, and no studies of the effects of such short bouts of activity on postprandial lipemia have been conducted.;OBJECTIVE:The objective was to compare the effects of accumulating ten 3-min bouts of exercise with those of one 30-min bout of exercise on postprandial plasma triacylglycerol concentrations.;DESIGN:Ten men aged 21-32 y completed three 2-d trials > or = 1 wk apart in a randomized repeated-measures design. On day 1, the subjects rested (no exercise) or ran at 70% of maximum oxygen uptake in either ten 3-min bouts (30 min rest between each) or one continuous 30-min bout. On day 2, the subjects rested and consumed test meals (0.69 g fat, 0.95 g carbohydrate, 0.31 g protein, and 46 kJ/kg body mass) for breakfast and lunch. Venous blood samples were obtained in the fasted state and for 7 h postprandially on day 2.;RESULTS:Postprandial plasma triacylglycerol concentrations were lower throughout day 2 of both the accumulation exercise trial and the continuous exercise trial than during the control trial (main effect of trial: P < 0.001, 2-factor analysis of variance).;CONCLUSIONS:Accumulating multiple short bouts of exercise throughout the day effectively reduce postprandial plasma triacylglycerol concentrations to an extent similar to that of a single 30-min session of exercise in healthy young men.