Research Areas
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Anatomy and histopathology of nervous system / Neuroscience-general
Details of a Researcher
Updated on 2024/12/07
日本神経化学会奨励賞
2001
Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma.
Yuebing Wang, Musukha Mala Brahma, Kazuya Takahashi, Alessandra Nolia Blanco Hernandez, Koki Ichikawa, Syuntaro Minami, Yoshio Goshima, Takayuki Harada, Toshio Ohshima
Neuromolecular medicine 26 ( 1 ) 13 - 13 2024.04 [International journal]
Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, Yoshio Goshima, Hideyuki Takeuchi, Hiroshi Doi, Fumio Nakamura, Fumiaki Tanaka
Frontiers in neurology 13 994676 - 994676 2022.09 [International journal]
Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models.
Musukha Mala Brahma, Kazuya Takahashi, Kazuhiko Namekata, Takayuki Harada, Yoshio Goshima, Toshio Ohshima
Genes to cells : devoted to molecular & cellular mechanisms 27 ( 8 ) 526 - 536 2022.08 [International journal]
Miyuki Takahashi, Toshiyuki Takasugi, Arisa Kawakami, Ran Wei, Kanae Ando, Toshio Ohshima, Shin-ichi Hisanaga
Neurochemical Research 47 ( 9 ) 2773 - 2779 2022.07 [Refereed] [International journal]
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.
Naoto Watamura, Kaori Sato, Gen Shiihashi, Ayami Iwasaki, Naoko Kamano, Mika Takahashi, Misaki Sekiguchi, Naomi Mihira, Ryo Fujioka, Kenichi Nagata, Shoko Hashimoto, Takashi Saito, Toshio Ohshima, Takaomi C Saido, Hiroki Sasaguri
Science advances 8 ( 23 ) eabm6155 2022.06 [Refereed] [International journal]
Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima
MOLECULAR BRAIN 15 ( 1 ) 2022.04 [Refereed]
Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4
Yuki Yamazaki, Maho Moizumi, Jun Nagai, Yoshiki Hatashita, Tianhong Cai, Papachan Kolattukudy, Takafumi Inoue, Yoshio Goshima, Toshio Ohshima
Cerebral cortex (New York, N.Y. : 1991) 32 ( 3 ) 520 - 527 2022.01 [Refereed]
Recent Advances in the Modeling of Alzheimer's Disease.
Hiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Kenya Sato, Wakako Kumita, Erika Sasaki, Shinobu Kitazume, Per Nilsson, Bengt Winblad, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido
Frontiers in neuroscience 16 807473 - 807473 2022 [Refereed] [International journal]
A 3rd generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.
Kaori Sato, Naoto Watamura, Ryo Fujioka, Naomi Mihira, Misaki Sekiguchi, Kenichi Nagata, Toshio Ohshima, Takashi Saito, Takaomi C Saido, Hiroki Sasaguri
The Journal of biological chemistry 101004 - 101004 2021.07 [International journal]
Cortical transcriptome analysis after spinal cord injury reveals the regenerative mechanism of central nervous system in CRMP2 knock-in mice.
Ayaka Sugeno, Wenhui Piao, Miki Yamazaki, Kiyofumi Takahashi, Koji Arikawa, Hiroko Matsunaga, Masahito Hosokawa, Daisuke Tominaga, Yoshio Goshima, Haruko Takeyama, Toshio Ohshima
Neural regeneration research 16 ( 7 ) 1258 - 1265 2021.07 [Refereed] [International journal]
Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.
Risa Takamura, Kotaro Mizuta, Yukiko Sekine, Tanvir Islam, Takashi Saito, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Toshio Ohshima, Takaomi C Saido, Yasunori Hayashi
The Journal of neuroscience : the official journal of the Society for Neuroscience 41 ( 24 ) 5315 - 5329 2021.06 [Refereed] [International journal]
Takeshi Kawashima, Aoi Jitsuki‐Takahashi, Kohtaro Takizawa, Susumu Jitsuki, Takuya Takahashi, Toshio Ohshima, Yoshio Goshima, Fumio Nakamura
Journal of Neurochemistry 2021.01
Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4.
Yuki Yamazaki, Jun Nagai, Satoshi Akinaga, Yumeno Koga, Masaya Hasegawa, Miyuki Takahashi, Naoya Yamashita, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima
Brain research 1736 146762 - 146762 2020.06 [Refereed] [International journal]
Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation.
Kentaro Togashi, Masaya Hasegawa, Jun Nagai, Ken Kotaka, Arina Yazawa, Miyuki Takahashi, Daiki Masukawa, Yoshio Goshima, Kenneth Hensley, Toshio Ohshima
Journal of the neurological sciences 413 116802 - 116802 2020.03 [Refereed] [International journal]
Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes
Hirotaka Fujita, Ryota Oikawa, Mayu Hayakawa, Fumiaki Tomoike, Yasuaki Kimura, Hiroyuki Okuno, Yoshiki Hatashita, Carolina Fiallos Oliveros, Haruhiko Bito, Toshio Ohshima, Satoshi Tsuneda, Hiroshi Abe, Takafumi Inoue
Journal of Biological Chemistry in press 2020 [Refereed] [International journal]
Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury.
Yuki Kinoshita, Syunsuke Kondo, Kazuya Takahashi, Jun Nagai, Shuji Wakatsuki, Toshiyuki Araki, Yoshio Goshima, Toshio Ohshima
Biochem Biophys Res Commun. 514 ( 4 ) 1037 - 1039 2019.07 [Refereed] [International journal]
Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A.
Yurika Numata-Uematsu, Shuji Wakatsuki, Seiichi Nagano, Megumi Shibata, Kazuhisa Sakai, Noritaka Ichinohe, Katsuhiko Mikoshiba, Toshio Ohshima, Naoya Yamashita, Yoshiro Goshima, Toshiyuki Araki
Neuroscience research 139 63 - 68 2019.02 [Refereed] [International journal]
Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's model mice.
Togashi K, Hasegawa M, Nagai J, Tonouchi A, Masukawa D, Hensley K, Goshima Y, Ohshima T
Genes to cells : devoted to molecular & cellular mechanisms 24 ( 1 ) 31 - 40 2018.10 [Refereed] [International journal]
Proteome and behavioral alterations in phosphorylation-deficient mutant Collapsin Response Mediator Protein2 knock-in mice.
Haruko Nakamura, Aoi Takahashi-Jitsuki, Hiroko Makihara, Tetsuya Asano, Yayoi Kimura, Jun Nakabayashi, Naoya Yamashita, Yuko Kawamoto, Fumio Nakamura, Toshio Ohshima, Hisashi Hirano, Fumiaki Tanaka, Yoshio Goshima
Neurochemistry international 119 207 - 217 2018.10 [Refereed] [International journal]
Excitatory Neuronal Hubs Configure Multisensory Integration of Slow Waves in Association Cortex
Satoshi Kuroki, Takamasa Yoshida, Hidekazu Tsutsui, Mizuho Iwama, Reiko Ando, Takayuki Michikawa, Atsushi Miyawaki, Toshio Ohshima, Shigeyoshi Itohara
Cell Reports 22 ( 11 ) 2809 - 2817 2018.03 [Refereed]
Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability.
Eriko Kamiki, Roman Boehringer, Denis Polygalov, Toshio Ohshima, Thomas J McHugh
Frontiers in cellular neuroscience 12 138 - 138 2018 [Refereed] [International journal]
Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm
Shoko Hashimoto, Ayano Ishii, Naoko Kamano, Naoto Watamura, Takashi Saito, Toshio Ohshima, Makoto Yokosuka, Takaomi C. Saido
Journal of Biological Chemistry 293 ( 9 ) 3118 - 3125 2018
Cdk5 activity is required for Purkinje cell dendritic growth in cell-autonomous and non-cell-autonomous manners
Bozong Xu, Ayumi Kumazawa, Shunsuke Kobayashi, Shin-ichi Hisanaga, Takafumi Inoue, Toshio Ohshima
DEVELOPMENTAL NEUROBIOLOGY 77 ( 10 ) 1175 - 1187 2017.10 [Refereed]
Wnt and Shh signals regulate neural stem cell proliferation and differentiation in the optic tectum of adult zebrafish
Shiori Shitasako, Yoko Ito, Ryoichi Ito, Yuto Ueda, Yuki Shimizu, Toshio Ohshima
DEVELOPMENTAL NEUROBIOLOGY 77 ( 10 ) 1206 - 1220 2017.10 [Refereed]
Zebrafish Mecp2 is required for proper axonal elongation of motor neurons and synapse formation
Keisuke Nozawa, Yanbin Lin, Ryota Kubodera, Yuki Shimizu, Hideomi Tanaka, Toshio Ohshima
DEVELOPMENTAL NEUROBIOLOGY 77 ( 9 ) 1101 - 1113 2017.09 [Refereed]
CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury
Jun Nagai, Rina Baba, Toshio Ohshima
MOLECULAR NEUROBIOLOGY 54 ( 6 ) 4243 - 4256 2017.08 [Refereed]
Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase
Fumio Nakamura, Takako Okada, Maria Shishikura, Noriko Uetani, Masahiko Taniguchi, Takeshi Yagi, Yoichiro Iwakura, Toshio Ohshima, Yoshio Goshima, Stephen M. Strittmatter
JOURNAL OF NEUROSCIENCE 37 ( 30 ) 7125 - 7139 2017.07 [Refereed]
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis
Brian T. D. Tobe, Andrew M. Crain, Alicia M. Winquist, Barbara Calabrese, Hiroko Makihara, Wen-ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D. Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steven D. Sheridan, Ryan W. Logan, Michael Brandel, Dongmei Wu, Joshua Hunsberger, Laurel Dorsett, Cordulla Duerr, Ranor C. B. Basa, Michael J. McCarthy, Namrata D. Udeshi, Philipp Mertins, Steven A. Carr, Guy A. Rouleau, Lina Mastrangelo, Jianxue Li, Gustavo J. Gutierrez, LaurenceM. Brill, Nikolaos Venizelos, Guang Chen, Jeffrey S. Nye, Husseini Manji, Jeffrey H. Price, Colleen A. McClung, Hagop S. Akiskal, Martin Alda, De-Maw M. Chuang, Joseph T. Coyle, Yang Liu, Yang D. Teng, Toshio Ohshima, Katsuhiko Mikoshiba, Richard L. Sidman, Shelley Halpain, Stephen J. Haggarty, Yoshio Goshima, Evan Y. Snyder
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114 ( 22 ) E4462 - E4471 2017.05 [Refereed]
CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling
Basem M. Abdallah, Florence Figeac, Kenneth H. Larsen, Nicholas Ditzel, Pankaj Keshari, Adiba Isa, Abbas Jafari, Thomas L. Andersen, Jean-Marie Delaisse, Yoshio Goshima, Toshio Ohshima, Moustapha Kassem
JOURNAL OF BONE AND MINERAL RESEARCH 32 ( 5 ) 913 - 926 2017.05 [Refereed]
Optic Nerve Input-Dependent Regulation of Neural Stem Cell Proliferation in the Optic Tectum of Adult Zebrafish
Yuki Sato, Hiroaki Yano, Yuki Shimizu, Hideomi Tanaka, Toshio Ohshima
DEVELOPMENTAL NEUROBIOLOGY 77 ( 4 ) 474 - 482 2017.04 [Refereed]
All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus in an Alzheimer's mouse model
Risa Takamura, Naoto Watamura, Miyu Nikkuni, Toshio Ohshima
JOURNAL OF NEUROSCIENCE RESEARCH 95 ( 3 ) 897 - 906 2017.03 [Refereed]
Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth
Ken Kotaka, Jun Nagai, Kenneth Hensley, Toshio Ohshima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483 ( 1 ) 759 - 764 2017.01 [Refereed]
CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain
Ryosuke Takaya, Jun Nagai, Wenfui Piao, Emi Niisato, Takeru Nakabayashi, Yuki Yamazaki, Fumio Nakamura, Naoya Yamashita, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima
BRAIN RESEARCH 1655 161 - 167 2017.01 [Refereed]
Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury
Jun Nagai, Ryosuke Takaya, Wenhui Piao, Yoshio Goshima, Toshio Ohshima
MOLECULAR AND CELLULAR NEUROSCIENCE 74 42 - 48 2016.07 [Refereed]
Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineinduced mouse model of Parkinson's disease
Aine Tonouchi, Jun Nagai, Kentaro Togashi, Yoshio Goshima, Toshio Ohshima
JOURNAL OF NEUROCHEMISTRY 137 ( 5 ) 795 - 805 2016.06 [Refereed]
PPAR gamma agonist pioglitazone improves cerebellar dysfunction at pre-A beta deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice
Junya Toba, Miyu Nikkuni, Masato Ishizeki, Aya Yoshii, Naoto Watamura, Takafumi Inoue, Toshio Ohshima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 473 ( 4 ) 1039 - 1044 2016.05 [Refereed]
Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain
Naoki Mita, Xiaojuan He, Kodai Sasamoto, Tomohide Mishiba, Toshio Ohshima
CEREBRAL CORTEX 26 ( 3 ) 967 - 976 2016.03 [Refereed]
Colocalization of Phosphorylated Forms of WAVE1, CRMP2, and Tau in Alzheimer's Disease Model Mice: Involvement of Cdk5 Phosphorylation and the Effect of ATRA Treatment
Naoto Watamura, Junya Toba, Aya Yoshii, Miyu Nikkuni, Toshio Ohshima
JOURNAL OF NEUROSCIENCE RESEARCH 94 ( 1 ) 15 - 26 2016.01 [Refereed]
Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus
Xiaohua Jin, Kodai Sasamoto, Jun Nagai, Yuki Yamazaki, Kenta Saito, Yoshio Goshima, Takafumi Inoue, Toshio Ohshima
NEURAL PLASTICITY 2016 2016 [Refereed]
Colocalization of Phosphorylated Forms of WAVE1, CRMP2, and Tau in Alzheimer's Disease Model Mice: Involvement of Cdk5 Phosphorylation and the Effect of ATRA Treatment
Naoto Watamura, Junya Toba, Aya Yoshii, Miyu Nikkuni, Toshio Ohshima
JOURNAL OF NEUROSCIENCE RESEARCH 94 ( 1 ) 15 - 26 2016.01
Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation
Jun Nagai, Yoshiteru Kitamura, Kazuki Owada, Naoya Yamashita, Kohtaro Takei, Yoshio Goshima, Toshio Ohshima
Scientific Reports 5 2015.02 [Refereed]
Neuronal migration and protein kinases
Toshio Ohshima
FRONTIERS IN NEUROSCIENCE 8 458 2015.01 [Refereed]
Genetic deletion of Crmp4 promotes axonal regrowth after spinal cord injury by reducing microtubule destabilization and inflammatory responses.
Nagai J, Kitamura Y, Owada K, Yamashita N, Takei K, Yoshio Goshima Y, Ohshima T
Sci. Rep 5 8269 2015
Cdk5/p35 functions as a crucial regulator of spatial learning and memory
Tomohide Mishiba, Mika Tanaka, Naoki Mita, Xiaojuan He, Kodai Sasamoto, Shigeyoshi Itohara, Toshio Ohshima
MOLECULAR BRAIN 7 2014.11 [Refereed]
Cdk5/p35 is required for motor coordination and cerebellar plasticity
Xiaojuan He, Masato Ishizeki, Naoki Mita, Seitaro Wada, Yoshifumi Araki, Hiroo Ogura, Manabu Abe, Maya Yamazaki, Kenji Sakimura, Katsuhiko Mikoshiba, Takafumi Inoue, Toshio Ohshima
JOURNAL OF NEUROCHEMISTRY 131 ( 1 ) 53 - 64 2014.10 [Refereed]
Cdk5/p35 is required for motor coordination and cerebellar plasticity.
Xiaojuan He, Masato Ishizeki, Naoki Mita, Seitaro Wada, Yoshifumi Araki, Hiroo Ogura, Manabu Abe, Maya Yamazaki, Kenji Sakimura, Katsuhiko Mikoshiba, Takafumi Inoue, Toshio Ohshima
Journal of neurochemistry 131 ( 1 ) 53 - 64 2014.10 [International journal]
Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
Yoshiaki V Nishimura, Mima Shikanai, Mikio Hoshino, Toshio Ohshima, Yo-ichi Nabeshima, Ken-Ichi Mizutani, Koh-Ichi Nagata, Kazunori Nakajima, Takeshi Kawauchi
Development (Cambridge, England) 141 ( 18 ) 3540 - 50 2014.09 [Refereed] [International journal]
Yuki Kuwabara, Masato Ishizeki, Naoto Watamura, Junya Toba, Aya Yoshii, Takafumi Inoue, Toshio Ohshima
JOURNAL OF NEUROCHEMISTRY 130 ( 3 ) 432 - 443 2014.08 [Refereed]
Phosphorylation of Cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5
Hiroyuki Kobayashi, Taro Saito, Ko Sato, Kotaro Furusawa, Tomohisa Hosokawa, Koji Tsutsumi, Akiko Asada, Shinji Kamada, Toshio Ohshima, Shin-Ichi Hisanaga
Journal of Biological Chemistry 289 ( 28 ) 19627 - 19636 2014.07
Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5
Hiroyuki Kobayashi, Taro Saito, Ko Sato, Kotaro Furusawa, Tomohisa Hosokawa, Koji Tsutsumi, Akiko Asada, Shinji Kamada, Toshio Ohshima, Shin-ichi Hisanaga
JOURNAL OF BIOLOGICAL CHEMISTRY 289 ( 28 ) 19627 - 19636 2014.07 [Refereed]
Phosphorylation of Drebrin by Cyclin-Dependent Kinase 5 and Its Role in Neuronal Migration
Kazuya Tanabe, Hiroyuki Yamazaki, Yutaka Inaguma, Akiko Asada, Taeko Kimura, Junya Takahashi, Masato Taoka, Toshio Ohshima, Teiichi Furuichi, Toshiaki Isobe, Koh-ichi Nagata, Tomoaki Shirao, Shin-ichi Hisanaga
PLOS ONE 9 ( 3 ) 2014.03 [Refereed]
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPAR gamma agonist improves neuronal loss and early lethality
Elias Utreras, Ryusuke Hamada, Michaela Prochazkova, Anita Terse, Satoru Takahashi, Toshio Ohshima, Ashok B. Kulkarni
JOURNAL OF NEUROINFLAMMATION 11 28 2014.02 [Refereed]
Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain.
Mita Naoki, He Xiaojuan, Sasamoto Kodai, Mishiba Tomohide, Ohshima Toshio
Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain. 2014
Transcription profiles of the ductus arteriosus in Brown-Norway rats with irregular elastic fiber formation
Yi-Ting Hsieh, Norika Mengchia Liu, Eriko Ohmori, Tomohiro Yokota, Ichige Kajimura, Toru Akaike, Toshio Ohshima, Nobuhito Goda, Susumu Minamisawa
Circulation Journal 78 ( 5 ) 1224 - 1233 2014
Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice
Yuki Kuwabara, Masato Ishizeki, Naoto Watamura, Junya Toba, Aya Yoshii, Takafumi Inoue, Toshio Ohshima
Journal of Neurochemistry 130 ( 3 ) 432 - 443 2014
Cyclin-dependent Kinase 5 (Cdk5) Regulates the Function of CLOCK Protein by Direct Phosphorylation
Yongdo Kwak, Jaehoon Jeong, Saebom Lee, Young-Un Park, Seol-Ae Lee, Dong-Hee Han, Joung-Hun Kim, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo-Hun Suh, Sehyung Cho, Sang Ki Park
JOURNAL OF BIOLOGICAL CHEMISTRY 288 ( 52 ) 36878 - 36889 2013.12 [Refereed]
Cyclin-dependent Kinase 5 (Cdk5) Regulates the Function of CLOCK Protein by Direct Phosphorylation
Yongdo Kwak, Jaehoon Jeong, Saebom Lee, Young-Un Park, Seol-Ae Lee, Dong-Hee Han, Joung-Hun Kim, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo-Hun Suh, Sehyung Cho, Sang Ki Park
JOURNAL OF BIOLOGICAL CHEMISTRY 288 ( 52 ) 36878 - 36889 2013.12 [Refereed]
Amyloid-beta(25-35) induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2
Toshinari Isono, Naoya Yamashita, Masami Obara, Tomomi Araki, Fumio Nakamura, Yoshinori Kamiya, Tursun Alkam, Atsumi Nitta, Toshitaka Nabeshima, Katsuhiko Mikoshiba, Toshio Ohshima, Yoshio Goshima
NEUROSCIENCE RESEARCH 77 ( 3 ) 180 - 185 2013.11 [Refereed]
Amyloid-beta(25-35) induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2
Toshinari Isono, Naoya Yamashita, Masami Obara, Tomomi Araki, Fumio Nakamura, Yoshinori Kamiya, Tursun Alkam, Atsumi Nitta, Toshitaka Nabeshima, Katsuhiko Mikoshiba, Toshio Ohshima, Yoshio Goshima
NEUROSCIENCE RESEARCH 77 ( 3 ) 180 - 185 2013.11 [Refereed]
IP(3)R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
Chihiro Hisatsune, Hiroyuki Miyamoto, Moritoshi Hirono, Naohide Yamaguchi, Takeyuki Sugawara, Naoko Ogawa, Etsuko Ebisui, Toshio Ohshima, Masahisa Yamada, Takao K. Hensch, Mitsuharu Hattori, Katsuhiko Mikoshiba
FRONTIERS IN NEURAL CIRCUITS 7 156 2013.10 [Refereed]
Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream
Dhananjay Huilgol, Susan Udin, Tomomi Shimogori, Bhaskar Saha, Achira Roy, Shinichi Aizawa, Robert F. Hevner, Gundela Meyer, Toshio Ohshima, Samuel J. Pleasure, Yangu Zhao, Shubha Tole
NATURE NEUROSCIENCE 16 ( 2 ) 157 - 165 2013.02 [Refereed]
Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream
Dhananjay Huilgol, Susan Udin, Tomomi Shimogori, Bhaskar Saha, Achira Roy, Shinichi Aizawa, Robert F. Hevner, Gundela Meyer, Toshio Ohshima, Samuel J. Pleasure, Yangu Zhao, Shubha Tole
NATURE NEUROSCIENCE 16 ( 2 ) 157 - 165 2013.02 [Refereed]
Cyclin-dependent kinase 5 is required for normal cerebellar development
A. Kumazawa, N. Mita, M. Hirasawa, T. Adachi, H. Suzuki, N. Shafeghat, A. B. Kulkarni, K. Mikoshiba, T. Inoue, T. Ohshima
MOLECULAR AND CELLULAR NEUROSCIENCE 52 97 - 105 2013.01 [Refereed]
Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons.
Niisato Emi, Nagai Jun, Yamashita Naoya, Nakamura Fumio, Goshima Yoshio, Ohshima Toshio
Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons. 73 ( 2 ) 142 - 151 2013 [International journal]
Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord.
Morimura Rii, Nozawa Keisuke, Tanaka Hideomi, Ohshima Toshio
Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord. 73 ( 12 ) 911 - 920 2013
p35 deficiency accelerates HMGB-1-mediated neuronal death in the early stages of an Alzheimer's disease mouse model
Ahram Jang, Hyunjeong Liew, Yun-Mi Kim, Heesoon Choi, Saeromi Kim, Sang Hyung Lee, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo-Hun Suh
Current Alzheimer Research 10 ( 8 ) 829 - 843 2013
Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish
Hideomi Tanaka, Rii Morimura, Toshio Ohshima
DEVELOPMENTAL BIOLOGY 370 ( 2 ) 223 - 236 2012.10 [Refereed]
Phosphorylation of Kif26b Promotes Its Polyubiquitination and Subsequent Proteasomal Degradation during Kidney Development
Takeshi Terabayashi, Masaji Sakaguchi, Kaori Shinmyozu, Toshio Ohshima, Ai Johjima, Teru Ogura, Hiroaki Miki, Ryuichi Nishinakamura
PLOS ONE 7 ( 6 ) 2012.06 [Refereed]
CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus.
Niisato Emi, Nagai Jun, Yamashita Naoya, Abe Takaya, Kiyonari Hiroshi, Goshima Yoshio, Ohshima Toshio
CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus. 72 ( 11 ) 1447 - 1457 2012 [International journal]
Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization
Naoya Yamashita, Toshio Ohshima, Fumio Nakamura, Papachan Kolattukudy, Jerome Honnorat, Katsuhiko Mikoshiba, Yoshio Goshima
JOURNAL OF NEUROSCIENCE 32 ( 4 ) 1360 - 1365 2012.01 [Refereed]
Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development
Terabayashi T, Sakaguchi M, Shinmyozu K, Ohshima T, Johjima A
PLoS ONE 7 ( 6 ) e39714 2012 [Refereed]
Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice
Xiaojuan He, Satoru Takahashi, Hiromi Suzuki, Tsutomu Hashikawa, Ashok B. Kulkarni, Katsuhiko Mikoshiba, Toshio Ohshima
Neurochemical Research 36 ( 7 ) 1293 - 1303 2011.07
Genetic manipulation of mammalian lateral and medial habenula homolog in zebrafish: Toward functional analysis of the habenula
Ryunosuke Amo, Masakazu Agetsuma, Masae Kinoshita, Toshiyuki Shiraki, Shin-ichi Higashijima, Masaru Matsuda, Maximiliano L. Suster, Koichi Kawakami, Toshio Ohshima, Hidenori Aizawa, Hitoshi Okamoto
NEUROSCIENCE RESEARCH 71 E271 - E271 2011 [Refereed]
Disturbed Purkinje cell spike activity produces dystonia in mice lacking the type 1 inositol 1,4,5-trisphosphate receptor
Chihiro Hisatsune, Hiroyuki Miyamoto, Moritoshi Hirono, Naohide Yamaguchi, Takeyuki Sugawara, Naoko Ogawa, Toshio Ohshima, Masahisa Yamada, Takao K. Hensch, Mitsuharu Hattori, Katsuhiko Mikoshiba
NEUROSCIENCE RESEARCH 71 E99 - E99 2011 [Refereed]
Islet1 Selectively Promotes Peripheral Axon Outgrowth in Rohon-Beard Primary Sensory Neurons
Hideomi Tanaka, Yasuhiro Nojima, Wataru Shoji, Miki Sato, Ryoko Nakayama, Toshio Ohshima, Hitoshi Okamoto
DEVELOPMENTAL DYNAMICS 240 ( 1 ) 9 - 22 2011.01 [Refereed]
Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum
Yoko Ito, Hideomi Tanaka, Hitoshi Okamoto, Toshio Ohshima
DEVELOPMENTAL BIOLOGY 342 ( 1 ) 26 - 38 2010.06 [Refereed]
Phosphorylation of AATYK1 by Cdk5 Suppresses Its Tyrosine Phosphorylation
Koji Tsutsumi, Tetsuya Takano, Ryo Endo, Mitsunori Fukuda, Toshio Ohshima, Mineko Tomomura, Shin-ichi Hisanaga
PLOS ONE 5 ( 4 ) e10260 2010.04 [Refereed]
Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration
Satoru Takahashi, Toshio Ohshima, Motoyuki Hirasawa, Tej K. Pareek, Thomas H. Bugge, Alexei Morozov, Kenji Fujieda, Roscoe O. Brady, Ashok B. Kulkarni
American Journal of Pathology 176 ( 1 ) 320 - 329 2010
Conditional Deletion of Neuronal Cyclin-Dependent Kinase 5 in Developing Forebrain Results in Microglial Activation and Neurodegeneration
Satoru Takahashi, Toshio Ohshima, Motoyuki Hirasawa, Tej K. Pareek, Thomas H. Bugge, Alexei Morozov, Kenji Fujieda, Roscoe O. Brady, Ashok B. Kulkarni
AMERICAN JOURNAL OF PATHOLOGY 176 ( 1 ) 320 - 329 2010.01 [Refereed]
Role of collapsin response mediator proteins for dendritic development in hippocampal CA1 pyramidal neurons
Emi Niisato, Naoya Yamashita, Fumio Nakamura, Yoshio Goshima, Toshio Ohshima
NEUROSCIENCE RESEARCH 68 E250 - E251 2010 [Refereed]
Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum.
Ito Yoko, Tanaka Hideomi, Okamoto Hitoshi, Ohshima Toshio
Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum. 342 ( 1 ) 26 - 38 2010
JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration.
Jin Junghee, Suzuki Hiromi, Hirai Syu-Ichi, Mikoshiba Katsuhiko, Ohshima Toshio
JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration. 70 ( 14 ) 929 - 942 2010
Semaphorin3A Signaling Mediated by Fyn-dependent Tyrosine Phosphorylation of Collapsin Response Mediator Protein 2 at Tyrosine 32
Yutaka Uchida, Toshio Ohshima, Naoya Yamashita, Miyuki Ogawara, Yukio Sasaki, Fumio Nakamura, Yoshio Goshima
JOURNAL OF BIOLOGICAL CHEMISTRY 284 ( 40 ) 27393 - 27401 2009.10 [Refereed]
Commitment of 1-Methyl-4-phenylpyrinidinium Ion-induced Neuronal Cell Death by Proteasome-mediated Degradation of p35 Cyclin-dependent Kinase 5 Activator
Ryo Endo, Taro Saito, Akiko Asada, Hiroyuki Kawahara, Toshio Ohshima, Shin-ichi Hisanaga
JOURNAL OF BIOLOGICAL CHEMISTRY 284 ( 38 ) 26029 - 26039 2009.09 [Refereed]
Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.
Nakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y
J Comp Neurol 516 ( 5 ) 360 - 375 2009.06
Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability
Sayuko Kaminosono, Taro Saito, Fumitaka Oyama, Toshio Ohshima, Akiko Asada, Yoshitaka Nagai, Nobuyuki Nukina, Shin-ichi Hisanaga
JOURNAL OF NEUROSCIENCE 28 ( 35 ) 8747 - 8755 2008.08 [Refereed]
Unusual patch-matrix organization in the retrosplenial cortex of the reeler mouse and Shaking rat Kawasaki
Noritaka Ichinohe, Adrian Knight, Masaharu Ogawa, Toshio Ohshima, Katsuhiko Mikoshiba, Yoshihiro Yoshihara, Toshio Terashima, Kathleen S. Rockland
CEREBRAL CORTEX 18 ( 5 ) 1125 - 1138 2008.05 [Refereed]
Regulation of spine development by Semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1
Naoya Yamashita, Asa Morita, Yutaka Uchida, Fumio Nakamura, Hiroshi Usui, Toshio Ohshima, Masahiko Taniguchi, Jerome Honnorat, Nicole Thomasset, Kohtaro Takei, Takuya Takahashi, Pappachan Kolattukudy, Yoshio Goshima
JOURNAL OF NEUROSCIENCE 27 ( 46 ) 12546 - 12554 2007.11 [Refereed]
Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone
Yuki Hirota, Toshio Ohshima, Naoko Kaneko, Makiko Ikeda, Takuji Iwasato, Ashok B. Kulkarni, Katsuhiko Mikoshiba, Hideyuki Okano, Kazunobu Sawamoto
JOURNAL OF NEUROSCIENCE 27 ( 47 ) 12829 - 12838 2007.11 [Refereed]
A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex
Ryan Remedios, Dhananjay Huilgol, Bhaskar Saha, Padmanabhan Hari, Lahar Bhatnagar, Thomas Kowalczyk, Robert F. Hevner, Yoko Suda, Shinichi Aizawa, Toshio Ohshima, Anastassia Stoykova, Shubha Tole
NATURE NEUROSCIENCE 10 ( 9 ) 1141 - 1150 2007.09 [Refereed]
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
Toshio Ohshima, Motoyuki Hirasawa, Hidenori Tabata, Tetsuji Mutoh, Tomoko Adachi, Hiromi Suzuki, Keiko Saruta, Takuji Iwasato, Shigeyoshi Itohara, Mistuhiro Hashimoto, Kazunori Nakajima, Masaharu Ogawa, Ashok B. Kulkarni, Katsuhiko Mikoshiba
DEVELOPMENT 134 ( 12 ) 2273 - 2282 2007.06 [Refereed]
Pak1 regulates dendritic branching and spine formation
Kanehiro Hayashi, Toshio Ohshima, Mitsuhiro Hashimoto, Katsuhiko Mikoshiba
DEVELOPMENTAL NEUROBIOLOGY 67 ( 5 ) 655 - 669 2007.04 [Refereed]
Modulation of Reelin signaling by cyclin-dependent kinase 5
Toshio Ohshima, Hiromi Suzuki, Toshifumi Morimura, Masaharu Ogawa, Katsuhiko Mikoshiba
BRAIN RESEARCH 1140 84 - 95 2007.04 [Refereed]
Collapsin response mediator protein 1 mediates Reelin signaling in cortical neuronal migration
Naoya Yamashita, Yutaka Uchida, Toshio Ohshima, Syu-ichi Hirai, Fumio Nakamura, Masahiko Taniguchi, Katsuhiko Mikoshiba, Jerome Honnorat, Pappachan Kolattukudy, Nicole Thomasset, Kohtaro Takei, Takuya Takahashi, Yoshio Goshima
JOURNAL OF NEUROSCIENCE 26 ( 51 ) 13357 - 13362 2006.12 [Refereed]
Phosphorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain
Kanehiro Hayashi, Yong Pan, Hongjun Shu, Toshio Ohshima, Janice W. Kansy, Charles L. White, Carol A. Tamminga, Andre Sobel, Patrick A. Curmi, Katsuhiko Mikoshiba, James A. Bibb
JOURNAL OF NEUROCHEMISTRY 99 ( 1 ) 237 - 250 2006.10 [Refereed]
Enhanced activation of Ca2+/calmodulin-dependent kinase II upon downregulation of Cyclin-dependent kinase 5-p35.
Hosokawa, T, Saito, T, Asada, A, Ohshima, T, Itakura, M, Takahashi, M, Fukunaga, K. Hisanaga, S
J. Neurosci. Res. 84 747 - 754 2006.06
cdk5 is required for neuroblast migration in the adult mouse brain
Yuki Hirota, Toshio Ohshima, Takuji Iwasato, Ashok B. Kulkarni, Hideyuki Okano, Kazunobu Sawamoto
NEUROSCIENCE RESEARCH 55 S52 - S52 2006
Impairment of hippocampal long-term depression and defective spatial learning and memory in p35(-/-) mice
T Ohshima, H Ogura, K Tomizawa, K Hayashi, H Suzuki, T Saito, H Kamei, A Nishi, JA Bibb, S Hisanaga, H Matsui, K Mikoshiba
JOURNAL OF NEUROCHEMISTRY 94 ( 4 ) 917 - 925 2005.08 [Refereed]
Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability
FY Wei, K Tomizawa, T Ohshima, A Asada, T Saito, C Nguyen, JA Bibb, K Ishiguro, AB Kulkarni, HC Pant, K Mikoshiba, H Matsui, S Hisanaga
JOURNAL OF NEUROCHEMISTRY 93 ( 2 ) 502 - 512 2005.04 [Refereed]
Satoru Takahashi, Toshio Ohshima, Andrew Cho, Taduru Sreenath, Michael J. Iadarola, Harish C. Pant, Yong Kim, Angus C. Nairn, Roscoe O. Brady, Paul Greengard, Ashok B. Kulkarni
Proceedings of the National Academy of Sciences 102 ( 5 ) 1737 - 1742 2005.02 [Refereed]
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3 beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease
Y Uchida, T Ohshima, Y Sasaki, H Suzuki, S Yanai, N Yamashita, F Nakamura, K Takei, Y Ihara, K Mikoshiba, P Kolattukudy, J Honnorat, Y Goshima
GENES TO CELLS 10 ( 2 ) 165 - 179 2005.02 [Refereed]
Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E
CX Li, Y Sasaki, K Takei, H Yamamoto, M Shouji, Y Sugiyama, T Kawakami, F Nakamura, T Yagi, T Ohshima, Y Goshima
JOURNAL OF NEUROSCIENCE 24 ( 27 ) 6161 - 6170 2004.07 [Refereed]
Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects
M Hirasawa, T Ohshima, S Takahashi, G Longenecker, Y Honjo, Veeranna, HC Pant, K Mikoshiba, RO Brady, AB Kulkarni
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101 ( 16 ) 6249 - 6254 2004.04 [Refereed]
Cophosphorylation of amphiphysin 1 and dynamin 1 by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles
K Tomizawa, S Sunada, YF Lu, Y Oda, M Kinuta, T Ohshima, T Saito, FY Wei, M Matsushita, ST Li, K Tsutsui, S Hisanaga, K Mikoshiba, K Takei, H Matsui
JOURNAL OF CELL BIOLOGY 163 ( 4 ) 813 - 824 2003.11 [Refereed]
Fyn and Cdk5 mediate Semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex
Y Sasaki, C Cheng, Y Uchida, O Nakajima, T Ohshima, T Yagi, M Taniguchi, T Nakayama, R Kishida, Y Kudo, S Ohno, F Nakamura, Y Goshima
NEURON 35 ( 5 ) 907 - 920 2002.08 [Refereed]
Toshio Ohshima, Masaharu Ogawa, Kyoko Takeuchi, Satoru Takahashi, Ashok B. Kulkarni, Katsuhiko Mikoshiba
The Journal of Neuroscience 22 ( 10 ) 4036 - 4044 2002.05 [Refereed]
Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain
Toshio Ohshima, Masaharu Ogawa, Veeranna, Motoyuki Hirasawa, Glenn Longenecker, Koichi Ishiguro, Harish C. Pant, Roscoe O. Brady, Ashok B. Kulkarni, Katsuhiko Mikoshiba
Proceedings of the National Academy of Sciences of the United States of America 98 ( 5 ) 2764 - 2769 2001.02
Phosphorylation of Drebrin by Cdk5 and its role in neuronal migration.
Tanabe K, Yamazaki J, Inaguma H, Asada A, Kimura T, Takahashi J, Taoka M, Ohshima T, Furuichi T, Isobe T, Nagata K, Shirao T, Hisanaga SI
PlosOne 9 3
Cyclin Dependent Kinase5
Ohshima, T
Spriger 2008 ISBN: 9780387788869
Requirement of Cdk5 for proper cerebellar development and function
2nd international symposium on Cdk5 Tokyo
Presentation date: 2009.06
Study on the role of CRMP2 phosphorylation in neural circuit formation and regeneration
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research
Project Year :
Cross-talk between endocrine and environmental factors in neuroimmune disorders
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research
Project Year :
CRMPをターゲットとした神経損傷・神経変性疾患治療戦略開発
Project Year :
Elucidation of roles of CRMP in neural circuit formation and regeneration and application for the treatment of spinal cord injury
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research
Project Year :
Ohshima Toshio, NAGAI Jun
Functional analysis of Cdk5 by using conditional KO of its activating subunit p35
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research
Project Year :
OHSHIMA Toshio
The role of CRMP family proteins in the establishment of neural tissue architectures
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research
Project Year :
GOSHIMA Yoshio, OOSHIMA Toshio
Proteomics of phospho-proteins during brain development using mutant mice
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research
Project Year :
OHSHIMA Toshio
Identification and functional analysis of Cdk5-mediated phosphorylation of the proteins that are related to brain formation and development
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research
Project Year :
OHSHIMA Toshio
神経特異的サイクリン依存性キナーゼ(cdk5)の個体レベルでの機能解析
誘導型コンディショナルKOを用いたCdk5の脳機能における役割の解明
Effect of valproic acid on Cdk5 activity and mouse behavior
M. Takahashi, M. Ishida, T. Saito, H. Kobayashi, A. Kawakami, T. Takasugi, T. Ohshima, S. Hisanaga
JOURNAL OF NEUROCHEMISTRY 130 37 - 37 2014.08
Research paper, summary (international conference)
The role of Tyr15 phosphorylation in Cdk5 activation
H. Kobayashi, T. Saito, K. Sato, T. Hosokawa, K. Tsutsumi, A. Asada, S. Kamada, T. Ohshima
JOURNAL OF NEUROCHEMISTRY 123 114 - 114 2012.10
Research paper, summary (international conference)
Sema3A regulates apical dendritic growth of hippocamal CA1 pyramidal neurons
Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Masahiko Taniguchi, Toshio Ohshima, Yoshio Goshima
NEUROSCIENCE RESEARCH 65 S46 - S46 2009
Research paper, summary (international conference)
Expression profiling of neural stem cell markers in dividing cells of the adult zebrafish optic tectum
Yoko Ito, Hideomi Tanaka, Hitoshi Okamoto, Toshio Ohshima
NEUROSCIENCE RESEARCH 61 S169 - S169 2008
Research paper, summary (international conference)
CRMP1 regulates spine maturation through mediating Semaphorin3A signaling in vivo
Naoya Yamashita, Asa Morita, Yutaka Uchida, Toshio Ohshima, Fumio Nakamura, Jerome Honnorat, Pappachan Kolattukudy, Yoshio Goshima
NEUROSCIENCE RESEARCH 58 S204 - S204 2007
Research paper, summary (international conference)
Phosphorylation of CRMP2 at S522 is required for proper dendritic patterning of layer V cortical neurons in vivo
Yutaka Uchida, Toshio Ohshima, Naoya Yamashita, Fumio Nakamura, Papachan Kolattukudy, Jerome Honnorat, Yoshio Goshima
NEUROSCIENCE RESEARCH 58 S203 - S203 2007
Research paper, summary (international conference)
Science and Engineering Laboratory 1B II
School of Creative Science and Engineering
2024 fall semester
Science and Engineering Laboratory 1A V
School of Creative Science and Engineering
2024 spring semester
Introduction to Bioscience A Sougoukikai
School of Creative Science and Engineering
2024 spring semester
Introduction to Bioscience A Kenchiku, keiei, shakou, shigen
School of Creative Science and Engineering
2024 spring semester
Introduction to Bioscience A Kagaku, Ouka
School of Advanced Science and Engineering
2024 spring semester
Science and Engineering Laboratory 1B II
School of Advanced Science and Engineering
2024 fall semester
Science and Engineering Laboratory 1A V
School of Advanced Science and Engineering
2024 spring semester
Introduction to Clinical Medicine [S Grade]
School of Advanced Science and Engineering
2024 fall semester
Life Science and Medical Bio-science Seminar II [S Grade]
School of Advanced Science and Engineering
2024 fall semester
Life Science and Medical Bio-science Seminar II
School of Advanced Science and Engineering
2024 fall semester
Life Science and Medical Bio-science Seminar I [S Grade]
School of Advanced Science and Engineering
2024 spring semester
Anatomy and Histology:Laboratory [S Grade]
School of Advanced Science and Engineering
2024 fall semester
Life Science and Medical Bio-science Seminar I
School of Advanced Science and Engineering
2024 spring semester
Life Science and Medical Bio-science Laboratory III [S Grade]
School of Advanced Science and Engineering
2024 fall semester
Life Science and Medical Bio-science Laboratory III
School of Advanced Science and Engineering
2024 fall semester
Life Science and Medical Bio-science Laboratory V
School of Advanced Science and Engineering
2024 fall semester
Life Science and Medical Bio-science Laboratory IV
School of Advanced Science and Engineering
2024 spring semester
Current Topics in Biosciences [S Grade]
School of Advanced Science and Engineering
2024 fall semester
Advanced Bioscience Laboratory [S Grade]
School of Advanced Science and Engineering
2024 fall semester
Master's Thesis (Department of Life Science and Medical Bioscience)
Graduate School of Advanced Science and Engineering
2024 full year
Master's Thesis (Department of Life Science and Medical Bioscience)
Graduate School of Advanced Science and Engineering
2024 full year
Research on Molecular Brain Science
Graduate School of Advanced Science and Engineering
2024 full year
Seminar on Molecular Brain Science D
Graduate School of Advanced Science and Engineering
2024 fall semester
Research on Molecular Brain Science
Graduate School of Advanced Science and Engineering
2024 full year
Seminar on Molecular Brain Science D
Graduate School of Advanced Science and Engineering
2024 fall semester
Seminar on Molecular Brain Science C
Graduate School of Advanced Science and Engineering
2024 spring semester
Seminar on Molecular Brain Science C
Graduate School of Advanced Science and Engineering
2024 spring semester
Seminar on Advanced Health Science III
Graduate School of Advanced Science and Engineering
2024 full year
Planning and Research for Advanced Health Science and Practical Presentation I
Graduate School of Advanced Science and Engineering
2024 an intensive course(spring and fall)
Seminar on Advanced Health Science I
Graduate School of Advanced Science and Engineering
2024 full year
Seminar on Advanced Health Science II
Graduate School of Advanced Science and Engineering
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Planning and Research for Advanced Health Science
Graduate School of Advanced Science and Engineering
2024 spring semester
Advanced Health Science Special Lecture
Graduate School of Advanced Science and Engineering
2024 an intensive course(spring and fall)
Practical Training for Career Building
Graduate School of Advanced Science and Engineering
2024 full year
Research on Molecular Brain Science
Graduate School of Advanced Science and Engineering
2024 full year
Medicine X Super-Aged Society, Career Design/Practitioners Graduated From Waseda University
Global Education Center
2024 fall quarter
Debate on Front of Modern Medical Care and Medical Issues
Global Education Center
2024 winter quarter
Advanced Medical Engineering of Radiation and Electromagnetic and life Science
Global Education Center
2024 summer
Introduction to Natural Science for a Carbon Neutral Society (Life Science)
Global Education Center
2024 fall quarter
Science and Engineering Laboratory 1B II
School of Fundamental Science and Engineering
2024 fall semester
Science and Engineering Laboratory 1A V
School of Fundamental Science and Engineering
2024 spring semester
Introduction to Bioscience A Denshibutsuri
School of Fundamental Science and Engineering
2024 spring semester
Faculty of Science and Engineering Graduate School of Advanced Science and Engineering
Affiliated organization Global Education Center
Waseda Research Institute for Science and Engineering Concurrent Researcher
2013