Concurrent Post
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Faculty of Science and Engineering Graduate School of Advanced Science and Engineering
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Affiliated organization Global Education Center
Details of a Researcher
Updated on 2022/05/26
Faculty of Science and Engineering Graduate School of Advanced Science and Engineering
Affiliated organization Global Education Center
理工学術院総合研究所 兼任研究員
Yamanashi Medical University MD, PhD
Neuroscience-general
Anatomy and histopathology of nervous system
Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm
Shoko Hashimoto, Ayano Ishii, Naoko Kamano, Naoto Watamura, Takashi Saito, Toshio Ohshima, Makoto Yokosuka, Takaomi C. Saido
Journal of Biological Chemistry 293 ( 9 ) 3118 - 3125 2018
Cdk5 activity is required for Purkinje cell dendritic growth in cell-autonomous and non-cell-autonomous manners
Bozong Xu, Ayumi Kumazawa, Shunsuke Kobayashi, Shin-ichi Hisanaga, Takafumi Inoue, Toshio Ohshima
DEVELOPMENTAL NEUROBIOLOGY 77 ( 10 ) 1175 - 1187 2017.10 [Refereed]
Wnt and Shh signals regulate neural stem cell proliferation and differentiation in the optic tectum of adult zebrafish
Shiori Shitasako, Yoko Ito, Ryoichi Ito, Yuto Ueda, Yuki Shimizu, Toshio Ohshima
DEVELOPMENTAL NEUROBIOLOGY 77 ( 10 ) 1206 - 1220 2017.10 [Refereed]
Zebrafish Mecp2 is required for proper axonal elongation of motor neurons and synapse formation
Keisuke Nozawa, Yanbin Lin, Ryota Kubodera, Yuki Shimizu, Hideomi Tanaka, Toshio Ohshima
DEVELOPMENTAL NEUROBIOLOGY 77 ( 9 ) 1101 - 1113 2017.09 [Refereed]
Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase
Fumio Nakamura, Takako Okada, Maria Shishikura, Noriko Uetani, Masahiko Taniguchi, Takeshi Yagi, Yoichiro Iwakura, Toshio Ohshima, Yoshio Goshima, Stephen M. Strittmatter
JOURNAL OF NEUROSCIENCE 37 ( 30 ) 7125 - 7139 2017.07 [Refereed]
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis
Brian T. D. Tobe, Andrew M. Crain, Alicia M. Winquist, Barbara Calabrese, Hiroko Makihara, Wen-ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D. Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steven D. Sheridan, Ryan W. Logan, Michael Brandel, Dongmei Wu, Joshua Hunsberger, Laurel Dorsett, Cordulla Duerr, Ranor C. B. Basa, Michael J. McCarthy, Namrata D. Udeshi, Philipp Mertins, Steven A. Carr, Guy A. Rouleau, Lina Mastrangelo, Jianxue Li, Gustavo J. Gutierrez, LaurenceM. Brill, Nikolaos Venizelos, Guang Chen, Jeffrey S. Nye, Husseini Manji, Jeffrey H. Price, Colleen A. McClung, Hagop S. Akiskal, Martin Alda, De-Maw M. Chuang, Joseph T. Coyle, Yang Liu, Yang D. Teng, Toshio Ohshima, Katsuhiko Mikoshiba, Richard L. Sidman, Shelley Halpain, Stephen J. Haggarty, Yoshio Goshima, Evan Y. Snyder
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114 ( 22 ) E4462 - E4471 2017.05 [Refereed]
CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling
Basem M. Abdallah, Florence Figeac, Kenneth H. Larsen, Nicholas Ditzel, Pankaj Keshari, Adiba Isa, Abbas Jafari, Thomas L. Andersen, Jean-Marie Delaisse, Yoshio Goshima, Toshio Ohshima, Moustapha Kassem
JOURNAL OF BONE AND MINERAL RESEARCH 32 ( 5 ) 913 - 926 2017.05 [Refereed]
Optic Nerve Input-Dependent Regulation of Neural Stem Cell Proliferation in the Optic Tectum of Adult Zebrafish
Yuki Sato, Hiroaki Yano, Yuki Shimizu, Hideomi Tanaka, Toshio Ohshima
DEVELOPMENTAL NEUROBIOLOGY 77 ( 4 ) 474 - 482 2017.04 [Refereed]
All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus in an Alzheimer's mouse model
Risa Takamura, Naoto Watamura, Miyu Nikkuni, Toshio Ohshima
JOURNAL OF NEUROSCIENCE RESEARCH 95 ( 3 ) 897 - 906 2017.03 [Refereed]
Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth
Ken Kotaka, Jun Nagai, Kenneth Hensley, Toshio Ohshima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483 ( 1 ) 759 - 764 2017.01 [Refereed]
CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain
Ryosuke Takaya, Jun Nagai, Wenfui Piao, Emi Niisato, Takeru Nakabayashi, Yuki Yamazaki, Fumio Nakamura, Naoya Yamashita, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima
BRAIN RESEARCH 1655 161 - 167 2017.01 [Refereed]
Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury
Jun Nagai, Ryosuke Takaya, Wenhui Piao, Yoshio Goshima, Toshio Ohshima
MOLECULAR AND CELLULAR NEUROSCIENCE 74 42 - 48 2016.07 [Refereed]
CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury
Nagai, Jun, Nagai, Jun, Baba, Rina, Ohshima, Toshio
Molecular Neurobiology 1 - 14 2016.06 [Refereed]
Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineinduced mouse model of Parkinson's disease
Aine Tonouchi, Jun Nagai, Kentaro Togashi, Yoshio Goshima, Toshio Ohshima
JOURNAL OF NEUROCHEMISTRY 137 ( 5 ) 795 - 805 2016.06 [Refereed]
PPAR gamma agonist pioglitazone improves cerebellar dysfunction at pre-A beta deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice
Junya Toba, Miyu Nikkuni, Masato Ishizeki, Aya Yoshii, Naoto Watamura, Takafumi Inoue, Toshio Ohshima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 473 ( 4 ) 1039 - 1044 2016.05 [Refereed]
Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain
Naoki Mita, Xiaojuan He, Kodai Sasamoto, Tomohide Mishiba, Toshio Ohshima
CEREBRAL CORTEX 26 ( 3 ) 967 - 976 2016.03 [Refereed]
Colocalization of Phosphorylated Forms of WAVE1, CRMP2, and Tau in Alzheimer's Disease Model Mice: Involvement of Cdk5 Phosphorylation and the Effect of ATRA Treatment
Naoto Watamura, Junya Toba, Aya Yoshii, Miyu Nikkuni, Toshio Ohshima
JOURNAL OF NEUROSCIENCE RESEARCH 94 ( 1 ) 15 - 26 2016.01 [Refereed]
Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus
Xiaohua Jin, Kodai Sasamoto, Jun Nagai, Yuki Yamazaki, Kenta Saito, Yoshio Goshima, Takafumi Inoue, Toshio Ohshima
NEURAL PLASTICITY 2016 2016 [Refereed]
Colocalization of Phosphorylated Forms of WAVE1, CRMP2, and Tau in Alzheimer's Disease Model Mice: Involvement of Cdk5 Phosphorylation and the Effect of ATRA Treatment
Naoto Watamura, Junya Toba, Aya Yoshii, Miyu Nikkuni, Toshio Ohshima
JOURNAL OF NEUROSCIENCE RESEARCH 94 ( 1 ) 15 - 26 2016.01
Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation.
Nagai Jun, Kitamura Yoshiteru, Owada Kazuki, Yamashita Naoya, Takei Kohtaro, Goshima Yoshio, Ohshima Toshio
Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation. 5 2015 [Refereed]
Cdk5/p35 functions as a crucial regulator of spatial learning and memory.
Mishiba T, Tanaka M, Mita N, He, Sasamoto K, Itohara S, Ohshima T
Mol Brain 7 82 2015
Neuronal migration and protein kinases
Toshio Ohshima
FRONTIERS IN NEUROSCIENCE 8 458 2015.01 [Refereed]
Genetic deletion of Crmp4 promotes axonal regrowth after spinal cord injury by reducing microtubule destabilization and inflammatory responses.
Nagai J, Kitamura Y, Owada K, Yamashita N, Takei K, Yoshio Goshima Y, Ohshima T
Sci. Rep 5 8269 2015
Cdk5/p35 is required for motor coordination and cerebellar plasticity.
Xiaojuan He, Masato Ishizeki, Naoki Mita, Seitaro Wada, Yoshifumi Araki, Hiroo Ogura, Manabu Abe, Maya Yamazaki, Kenji Sakimura, Katsuhiko Mikoshiba, Takafumi Inoue, Toshio Ohshima
Journal of neurochemistry 131 ( 1 ) 53 - 64 2014.10 [International journal]
Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
Yoshiaki V Nishimura, Mima Shikanai, Mikio Hoshino, Toshio Ohshima, Yo-ichi Nabeshima, Ken-Ichi Mizutani, Koh-Ichi Nagata, Kazunori Nakajima, Takeshi Kawauchi
Development (Cambridge, England) 141 ( 18 ) 3540 - 50 2014.09 [Refereed] [International journal]
Phosphorylation of Cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5
Hiroyuki Kobayashi, Taro Saito, Ko Sato, Kotaro Furusawa, Tomohisa Hosokawa, Koji Tsutsumi, Akiko Asada, Shinji Kamada, Toshio Ohshima, Shin-Ichi Hisanaga
Journal of Biological Chemistry 289 ( 28 ) 19627 - 19636 2014.07
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPAR gamma agonist improves neuronal loss and early lethality
Elias Utreras, Ryusuke Hamada, Michaela Prochazkova, Anita Terse, Satoru Takahashi, Toshio Ohshima, Ashok B. Kulkarni
JOURNAL OF NEUROINFLAMMATION 11 28 2014.02 [Refereed]
Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain.
Mita Naoki, He Xiaojuan, Sasamoto Kodai, Mishiba Tomohide, Ohshima Toshio
Cyclin-Dependent Kinase 5 Regulates Dendritic Spine Formation and Maintenance of Cortical Neuron in the Mouse Brain. 2014
Cdk5/p35 functions as a crucial regulator of spatial learning and memory.
Mishiba Tomohide, Tanaka Mika, Mita Naoki, He Xiaojuan, Sasamoto Kodai, Itohara Shigeyoshi, Ohshima Toshio
Cdk5/p35 functions as a crucial regulator of spatial learning and memory. 7 2014 [Refereed]
Transcription profiles of the ductus arteriosus in Brown-Norway rats with irregular elastic fiber formation
Yi-Ting Hsieh, Norika Mengchia Liu, Eriko Ohmori, Tomohiro Yokota, Ichige Kajimura, Toru Akaike, Toshio Ohshima, Nobuhito Goda, Susumu Minamisawa
Circulation Journal 78 ( 5 ) 1224 - 1233 2014
Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration.
Tanabe Kazuya, Yamazaki Hiroyuki, Inaguma Yutaka, Asada Akiko, Kimura Taeko, Takahashi Junya, Taoka Masato, Ohshima Toshio, Furuichi Teiichi, Isobe Toshiaki, Nagata Koh-ichi, Shirao Tomoaki, Hisanaga Shin-ichi
Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. 9 ( 3 ) 2014 [Refereed]
Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice
Yuki Kuwabara, Masato Ishizeki, Naoto Watamura, Junya Toba, Aya Yoshii, Takafumi Inoue, Toshio Ohshima
Journal of Neurochemistry 130 ( 3 ) 432 - 443 2014
Phosphorylation of Cdk5 at Tyr15 is inhibited by the Cdk5 activator p35 and does not contribute the activation of Cdk5.
Kobayashi H, Saito T, Sato K, Hosokawa T, Tsutsumi K, Asada A, Kamata S, OhshimaT, Hisanaga S-I
J. Biol. Chem 289 19627 - 19636 2014 [Refereed]
Cyclin-dependent Kinase 5 (Cdk5) Regulates the Function of CLOCK Protein by Direct Phosphorylation
Yongdo Kwak, Jaehoon Jeong, Saebom Lee, Young-Un Park, Seol-Ae Lee, Dong-Hee Han, Joung-Hun Kim, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo-Hun Suh, Sehyung Cho, Sang Ki Park
JOURNAL OF BIOLOGICAL CHEMISTRY 288 ( 52 ) 36878 - 36889 2013.12 [Refereed]
Amyloid-beta(25-35) induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2
Toshinari Isono, Naoya Yamashita, Masami Obara, Tomomi Araki, Fumio Nakamura, Yoshinori Kamiya, Tursun Alkam, Atsumi Nitta, Toshitaka Nabeshima, Katsuhiko Mikoshiba, Toshio Ohshima, Yoshio Goshima
NEUROSCIENCE RESEARCH 77 ( 3 ) 180 - 185 2013.11 [Refereed]
Amyloid-beta(25-35) induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2
Toshinari Isono, Naoya Yamashita, Masami Obara, Tomomi Araki, Fumio Nakamura, Yoshinori Kamiya, Tursun Alkam, Atsumi Nitta, Toshitaka Nabeshima, Katsuhiko Mikoshiba, Toshio Ohshima, Yoshio Goshima
NEUROSCIENCE RESEARCH 77 ( 3 ) 180 - 185 2013.11 [Refereed]
IP(3)R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice
Chihiro Hisatsune, Hiroyuki Miyamoto, Moritoshi Hirono, Naohide Yamaguchi, Takeyuki Sugawara, Naoko Ogawa, Etsuko Ebisui, Toshio Ohshima, Masahisa Yamada, Takao K. Hensch, Mitsuharu Hattori, Katsuhiko Mikoshiba
FRONTIERS IN NEURAL CIRCUITS 7 156 2013.10 [Refereed]
Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream
Dhananjay Huilgol, Susan Udin, Tomomi Shimogori, Bhaskar Saha, Achira Roy, Shinichi Aizawa, Robert F. Hevner, Gundela Meyer, Toshio Ohshima, Samuel J. Pleasure, Yangu Zhao, Shubha Tole
NATURE NEUROSCIENCE 16 ( 2 ) 157 - 165 2013.02 [Refereed]
Cyclin-dependent kinase 5 is required for normal cerebellar development
A. Kumazawa, N. Mita, M. Hirasawa, T. Adachi, H. Suzuki, N. Shafeghat, A. B. Kulkarni, K. Mikoshiba, T. Inoue, T. Ohshima
MOLECULAR AND CELLULAR NEUROSCIENCE 52 97 - 105 2013.01 [Refereed]
Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons.
Niisato Emi, Nagai Jun, Yamashita Naoya, Nakamura Fumio, Goshima Yoshio, Ohshima Toshio
Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons. 73 ( 2 ) 142 - 151 2013 [International journal]
Cdk5 regulates the function of CLOCK protein by direct phosphorylation.
Kwak Y, Jeong J, Lee S, Park YU, Lee SA, Han DH, Kim JH, Ohshima T, Mikoshiba K, Suh YH, Cho S
J. Biol. Chem. 288 36878 - 36889 2013 [Refereed]
Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord.
Morimura Rii, Nozawa Keisuke, Tanaka Hideomi, Ohshima Toshio
Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord. 73 ( 12 ) 911 - 920 2013
ual origin of the mammalian accessory olfactory bulb revealed by an an evolutionarily conserved long distance migratory stream.
Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner R, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S
Nat. Neurosci. 16 157 - 165 2013 [Refereed]
p35 deficiency accelerates HMGB-1-mediated neuronal death in the early stages of an Alzheimer's disease mouse model
Ahram Jang, Hyunjeong Liew, Yun-Mi Kim, Heesoon Choi, Saeromi Kim, Sang Hyung Lee, Toshio Ohshima, Katsuhiko Mikoshiba, Yoo-Hun Suh
Current Alzheimer Research 10 ( 8 ) 829 - 843 2013
Phosphorylation of Kif26b Promotes Its Polyubiquitination and Subsequent Proteasomal Degradation during Kidney Development
Takeshi Terabayashi, Masaji Sakaguchi, Kaori Shinmyozu, Toshio Ohshima, Ai Johjima, Teru Ogura, Hiroaki Miki, Ryuichi Nishinakamura
PLOS ONE 7 ( 6 ) 2012.06 [Refereed]
CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus.
Niisato Emi, Nagai Jun, Yamashita Naoya, Abe Takaya, Kiyonari Hiroshi, Goshima Yoshio, Ohshima Toshio
CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus. 72 ( 11 ) 1447 - 1457 2012 [International journal]
Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization
Naoya Yamashita, Toshio Ohshima, Fumio Nakamura, Papachan Kolattukudy, Jerome Honnorat, Katsuhiko Mikoshiba, Yoshio Goshima
JOURNAL OF NEUROSCIENCE 32 ( 4 ) 1360 - 1365 2012.01 [Refereed]
Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development
Terabayashi T, Sakaguchi M, Shinmyozu K, Ohshima T, Johjima A
PLoS ONE 7 ( 6 ) e39714 2012 [Refereed]
Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice
Xiaojuan He, Satoru Takahashi, Hiromi Suzuki, Tsutomu Hashikawa, Ashok B. Kulkarni, Katsuhiko Mikoshiba, Toshio Ohshima
Neurochemical Research 36 ( 7 ) 1293 - 1303 2011.07
Genetic manipulation of mammalian lateral and medial habenula homolog in zebrafish: Toward functional analysis of the habenula
Ryunosuke Amo, Masakazu Agetsuma, Masae Kinoshita, Toshiyuki Shiraki, Shin-ichi Higashijima, Masaru Matsuda, Maximiliano L. Suster, Koichi Kawakami, Toshio Ohshima, Hidenori Aizawa, Hitoshi Okamoto
NEUROSCIENCE RESEARCH 71 E271 - E271 2011 [Refereed]
Disturbed Purkinje cell spike activity produces dystonia in mice lacking the type 1 inositol 1,4,5-trisphosphate receptor
Chihiro Hisatsune, Hiroyuki Miyamoto, Moritoshi Hirono, Naohide Yamaguchi, Takeyuki Sugawara, Naoko Ogawa, Toshio Ohshima, Masahisa Yamada, Takao K. Hensch, Mitsuharu Hattori, Katsuhiko Mikoshiba
NEUROSCIENCE RESEARCH 71 E99 - E99 2011 [Refereed]
Islet1 Selectively Promotes Peripheral Axon Outgrowth in Rohon-Beard Primary Sensory Neurons
Hideomi Tanaka, Yasuhiro Nojima, Wataru Shoji, Miki Sato, Ryoko Nakayama, Toshio Ohshima, Hitoshi Okamoto
DEVELOPMENTAL DYNAMICS 240 ( 1 ) 9 - 22 2011.01 [Refereed]
Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum
Yoko Ito, Hideomi Tanaka, Hitoshi Okamoto, Toshio Ohshima
DEVELOPMENTAL BIOLOGY 342 ( 1 ) 26 - 38 2010.06 [Refereed]
Phosphorylation of AATYK1 by Cdk5 Suppresses Its Tyrosine Phosphorylation
Koji Tsutsumi, Tetsuya Takano, Ryo Endo, Mitsunori Fukuda, Toshio Ohshima, Mineko Tomomura, Shin-ichi Hisanaga
PLOS ONE 5 ( 4 ) e10260 2010.04 [Refereed]
Conditional Deletion of Neuronal Cyclin-Dependent Kinase 5 in Developing Forebrain Results in Microglial Activation and Neurodegeneration
Satoru Takahashi, Toshio Ohshima, Motoyuki Hirasawa, Tej K. Pareek, Thomas H. Bugge, Alexei Morozov, Kenji Fujieda, Roscoe O. Brady, Ashok B. Kulkarni
AMERICAN JOURNAL OF PATHOLOGY 176 ( 1 ) 320 - 329 2010.01 [Refereed]
Role of collapsin response mediator proteins for dendritic development in hippocampal CA1 pyramidal neurons
Emi Niisato, Naoya Yamashita, Fumio Nakamura, Yoshio Goshima, Toshio Ohshima
NEUROSCIENCE RESEARCH 68 E250 - E251 2010 [Refereed]
Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum.
Ito Yoko, Tanaka Hideomi, Okamoto Hitoshi, Ohshima Toshio
Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum. 342 ( 1 ) 26 - 38 2010
JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration.
Jin Junghee, Suzuki Hiromi, Hirai Syu-Ichi, Mikoshiba Katsuhiko, Ohshima Toshio
JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration. 70 ( 14 ) 929 - 942 2010
Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.
Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y
J Biol Chem. 284 ( 40 ) 27393 - 27401 2009.10 [Refereed]
Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 Cyclin-dependent kinase 5 activator.
Endo R, Saito T, Asada A, Kawahara H, Ohshima T, Hisanaga SI
J Biol Chem 284 ( 38 ) 26029 - 26039 2009.09 [Refereed]
Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.
Nakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y
J Comp Neurol 516 ( 5 ) 360 - 375 2009.06
Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.
Takahashi S, Ohshima T, Hirasawa M, Pareek TK, Bugge TH, Morozov A, Fujieda K, Brady RO, KulkarniAB
American J Pathology in press 2009
Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.
Kaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N, Hisanaga S
J Neurosci. 28 ( 35 ) 8747 - 55 2008.08 [Refereed]
Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.
Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y
J Neurosci 27 ( 46 ) 12546 - 54 2007.11 [Refereed]
Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone.
Hirota Y, Ohshima T, Kaneko N, Ikeda M, Iwasato T, Kulkarni AB, Mikoshiba K, Okano H, Sawamoto K
J Neurosci 27 ( 47 ) 12829 - 38 2007.11 [Refereed]
A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.
Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Kowalczyk T, Hevner RF, Suda Y, Aizawa S, Ohshima T, Stoykova A, Tole S
Nat Neurosci 10 ( 9 ) 1141 - 50 2007.09 [Refereed]
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
Toshio Ohshima, Motoyuki Hirasawa, Hidenori Tabata, Tetsuji Mutoh, Tomoko Adachi, Hiromi Suzuki, Keiko Saruta, Takuji Iwasato, Shigeyoshi Itohara, Mistuhiro Hashimoto, Kazunori Nakajima, Masaharu Ogawa, Ashok B. Kulkarni, Katsuhiko Mikoshiba
DEVELOPMENT 134 ( 12 ) 2273 - 2282 2007.06 [Refereed]
Pak1 regulates dendritic branching and spine formation
Kanehiro Hayashi, Toshio Ohshima, Mitsuhiro Hashimoto, Katsuhiko Mikoshiba
DEVELOPMENTAL NEUROBIOLOGY 67 ( 5 ) 655 - 669 2007.04 [Refereed]
Modulation of Reelin signaling by cyclin-dependent kinase 5
Toshio Ohshima, Hiromi Suzuki, Toshifumi Morimura, Masaharu Ogawa, Katsuhiko Mikoshiba
BRAIN RESEARCH 1140 84 - 95 2007.04 [Refereed]
CRMP1 mediates Reelin signaling in cortical neuronal migration.
Yamashita, N, Uchida, Y, Ohshima, T, Hirai, S-I, Nakamura, F, Masahiko Taniguchi, M, Mikoshiba, K, Honnorat, J, Kolattukudy, P, Nicole Thomasset, N, Takei, K, Takahashi, T, Yoshio Goshima, Y
J. Neurosci. 26(51):13357-62. ( 51 ) 13357 - 13362 2006.12 [Refereed]
Phosphorylation of the tubulin-binding protein, stathmin, by Cdk5 and MAP kinases in the brain
Kanehiro Hayashi, Yong Pan, Hongjun Shu, Toshio Ohshima, Janice W. Kansy, Charles L. White, Carol A. Tamminga, Andre Sobel, Patrick A. Curmi, Katsuhiko Mikoshiba, James A. Bibb
JOURNAL OF NEUROCHEMISTRY 99 ( 1 ) 237 - 250 2006.10 [Refereed]
Enhanced activation of Ca2+/calmodulin-dependent kinase II upon downregulation of Cyclin-dependent kinase 5-p35.
Hosokawa, T, Saito, T, Asada, A, Ohshima, T, Itakura, M, Takahashi, M, Fukunaga, K. Hisanaga, S
J. Neurosci. Res. 84 747 - 754 2006.06
Phosphorylation of Drebrin by Cdk5 and its role in neuronal migration.
Tanabe K, Yamazaki J, Inaguma H, Asada A, Kimura T, Takahashi J, Taoka M, Ohshima T, Furuichi T, Isobe T, Nagata K, Shirao T, Hisanaga SI
PlosOne 9 3
Cyclin Dependent Kinase5
Ohshima, T
Spriger 2008 ISBN: 9780387788869
日本神経化学会奨励賞
2001
Cross-talk between endocrine and environmental factors in neuroimmune disorders
Project Year :
CRMPをターゲットとした神経損傷・神経変性疾患治療戦略開発
Project Year :
Elucidation of roles of CRMP in neural circuit formation and regeneration and application for the treatment of spinal cord injury
Project Year :
神経特異的サイクリン依存性キナーゼ(cdk5)の個体レベルでの機能解析
Identification and functional analysis of Cdk5-mediated phosphorylation of the proteins that are related to brain formation and development
The role of CRMP family proteins in the establishment of neural tissue architectures
Proteomics of phospho-proteins during brain development using mutant mice
誘導型コンディショナルKOを用いたCdk5の脳機能における役割の解明
Functional analysis of Cdk5 by using conditional KO of its activating subunit p35
Requirement of Cdk5 for proper cerebellar development and function
2nd international symposium on Cdk5 Tokyo
Presentation date: 2009.06
2013
Seminar on Molecular Brain Science D
Graduate School of Advanced Science and Engineering
2022 fall semester
Seminar on Molecular Brain Science C
Graduate School of Advanced Science and Engineering
2022 spring semester
Research on Molecular Brain Science
Graduate School of Advanced Science and Engineering
2022 full year
Master's Thesis (Department of Life Science and Medical Bioscience)
Graduate School of Advanced Science and Engineering
2022 full year
Practical Training for Career Building
Graduate School of Advanced Science and Engineering
2022 full year
Research on Molecular Brain Science
Graduate School of Advanced Science and Engineering
2022 full year
Seminar on Advanced Health Science III
Graduate School of Advanced Science and Engineering
2022 full year
Seminar on Advanced Health Science II
Graduate School of Advanced Science and Engineering
2022 full year
Seminar on Advanced Health Science I
Graduate School of Advanced Science and Engineering
2022 full year
Planning and Research for Advanced Health Science
Graduate School of Advanced Science and Engineering
2022 spring semester
Health and Medical Science for Brain and Mind
Graduate School of Advanced Science and Engineering
2022 spring semester
Seminar on Molecular Brain Science D
Graduate School of Advanced Science and Engineering
2022 fall semester
Seminar on Molecular Brain Science C
Graduate School of Advanced Science and Engineering
2022 spring semester
Research on Molecular Brain Science
Graduate School of Advanced Science and Engineering
2022 full year
Master's Thesis (Department of Life Science and Medical Bioscience)
Graduate School of Advanced Science and Engineering
2022 full year
Medicine X Public Administration,Law,Ethics/Practitioners Graduated From Waseda University
Global Education Center
2022 winter quarter
Medicine X Super-Aged Society,Carrier Design/Practitioners Graduated From Waseda University
Global Education Center
2022 fall quarter
Medicine X Business,Economy,Management/Practitioners Graduated From Waseda University
Global Education Center
2022 summer quarter
Medicine X AI,Big Data,IoT/Practitioners Graduated From Waseda University
Global Education Center
2022 spring quarter
Advanced Medical Engineering of Radiation and Electromagnetic and life Science
Global Education Center
2022 summer
Science and Engineering Laboratory 1A V
School of Fundamental Science and Engineering
2022 spring semester
Science and Engineering Laboratory 1B II
School of Fundamental Science and Engineering
2022 fall semester
Science and Engineering Laboratory 1B II
School of Creative Science and Engineering
2022 fall semester
Science and Engineering Laboratory 1A V
School of Creative Science and Engineering
2022 spring semester
Introduction to Bioscience A Sougoukikai
School of Creative Science and Engineering
2022 spring semester
Science and Engineering Laboratory 1B II
School of Advanced Science and Engineering
2022 fall semester
Science and Engineering Laboratory 1A V
School of Advanced Science and Engineering
2022 spring semester
Introduction to Bioscience A Kagaku, Ouka
School of Advanced Science and Engineering
2022 spring semester
Life Science and Medical Bio-science Laboratory III [S Grade]
School of Advanced Science and Engineering
2022 fall semester
Life Science and Medical Bio-science Laboratory III
School of Advanced Science and Engineering
2022 fall semester
Introduction to Clinical Medicine [S Grade]
School of Advanced Science and Engineering
2022 fall semester
Life Science and Medical Bio-science Seminar II [S Grade]
School of Advanced Science and Engineering
2022 fall semester
Life Science and Medical Bio-science Seminar II
School of Advanced Science and Engineering
2022 fall semester
Life Science and Medical Bio-science Laboratory V
School of Advanced Science and Engineering
2022 fall semester
Anatomy and Histology:Laboratory [S Grade]
School of Advanced Science and Engineering
2022 fall semester
Life Science and Medical Bio-science Seminar I [S Grade]
School of Advanced Science and Engineering
2022 spring semester
Life Science and Medical Bio-science Seminar I
School of Advanced Science and Engineering
2022 spring semester
Life Science and Medical Bio-science Laboratory IV
School of Advanced Science and Engineering
2022 spring semester
Current Topics in Biosciences [S Grade]
School of Advanced Science and Engineering
2022 fall semester
Advanced Bioscience Laboratory [S Grade]
School of Advanced Science and Engineering
2022 fall semester